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Acetaminophen/Guaifenesin/Dextromethorphan hydrobromide/Phenylephrine hydrochlo…
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- Active ingredients
- Acetaminophen 325 mg/15 mL
- Guaifenesin 200 mg/15 mL
- Dextromethorphan Hydrobromide 10 mg/15 mL
- Phenylephrine Hydrochloride 5 mg/15 mL
- Reference brand
- Vicks Dayquil Nyquil Severe Honey
- Dosage form
- Liquid
- Route
- Oral
- Prescription status
- OTC (over the counter)
- Marketed in the U.S.
- Since 2020
- Label revision date
- February 19, 2026
- Pregnancy
- See Pregnancy Use Section
- Lactation
- See Lactation Use Section
- Active ingredients
- Acetaminophen 325 mg/15 mL
- Guaifenesin 200 mg/15 mL
- Dextromethorphan Hydrobromide 10 mg/15 mL
- Phenylephrine Hydrochloride 5 mg/15 mL
- Reference brand
- Vicks Dayquil Nyquil Severe Honey
- Dosage form
- Liquid
- Route
- Oral
- Prescription status
- OTC (over the counter)
- CSA schedule
- Not a scheduled drug
- Marketed in the U.S.
- Since 2020
- Label revision date
- February 19, 2026
- Pregnancy
- See Pregnancy Use Section
- Lactation
- See Lactation Use Section
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Drug Overview
Vicks Dayquil Nyquil Severe Honey is a combination cold and flu relief product that comes in liquid form and is flavored with real honey. It includes two formulations: DayQuil, which contains acetaminophen, dextromethorphan HBr, guaifenesin, and phenylephrine HCl, and NyQuil, which contains acetaminophen, dextromethorphan HBr, doxylamine succinate, and phenylephrine HCl. This product is designed to temporarily relieve common cold and flu symptoms such as nasal congestion, sinus pressure, cough, headache, fever, sore throat, and minor aches and pains.
DayQuil provides non-drowsy relief during the day, while NyQuil is formulated for nighttime use, helping you sleep by alleviating cough and other symptoms. Together, they promote easier breathing and help manage the discomfort associated with colds and flu.
Uses
Vicks Dayquil Nyquil Severe Honey is designed to temporarily relieve a variety of common cold and flu symptoms. If you're experiencing nasal congestion, sinus pressure, or a cough due to minor throat and bronchial irritation, this product can help. It also addresses minor aches and pains, headaches, fever, sore throat, runny nose, and sneezing. Additionally, it works to reduce swelling in your nasal passages, promoting easier breathing and aiding in nasal and sinus drainage.
This liquid formulation is suitable for helping you feel more comfortable when you're under the weather, allowing you to rest and recover more effectively.
Dosage and Administration
You should take Vicks Dayquil Nyquil Severe Honey only as directed, using the dose cup provided. For adults and children aged 12 years and older, the recommended dose is 30 mL every 4 hours. If your child is between 6 and under 12 years old, give them 15 mL every 4 hours.
Do not use this medication for children aged 4 to under 6 years unless directed by a doctor, and it is not safe for children under 4 years old. Remember not to exceed 4 doses in a 24-hour period.
What to Avoid
You should avoid using this product if you are currently taking any other medication that contains acetaminophen (a common pain reliever) or if you are unsure whether a drug contains acetaminophen—consult a doctor or pharmacist for clarification. Additionally, do not use this product if you are taking a prescription monoamine oxidase inhibitor (MAOI), which is used for certain psychiatric conditions, or within two weeks of stopping such medication. Lastly, do not use this product to induce sleepiness in children.
Side Effects
You should be aware of several potential side effects when using Vicks Dayquil Nyquil Severe Honey. This product contains acetaminophen, which can lead to severe liver damage if you exceed the recommended doses (more than 4 doses in 24 hours for adults and children) or consume alcohol while using it. Additionally, acetaminophen may cause serious skin reactions, such as redness, blisters, or rash; if you experience these, stop using the product and seek medical help immediately.
While using this medication, you may experience marked drowsiness or excitability, especially in children. It's important to avoid alcohol and be cautious when driving or operating machinery, as these can increase drowsiness. If you feel nervous, dizzy, or if your symptoms worsen or persist beyond the recommended duration, consult a doctor. Always check with a healthcare professional if you have pre-existing conditions like liver disease, heart disease, or if you are taking other medications, especially blood thinners or sedatives.
Warnings and Precautions
If you are using Vicks Dayquil Nyquil Severe Honey, be aware that it contains acetaminophen, which can cause severe liver damage if you exceed the recommended doses. For adults, do not take more than 4 doses (30 mL each) in 24 hours, and for children, do not exceed 4 doses (15 mL each). Avoid using this product with other medications that contain acetaminophen or if you consume 3 or more alcoholic drinks daily.
Watch for severe skin reactions, such as skin reddening, blisters, or rash. If you experience any of these symptoms, stop using the product and seek medical help immediately. Additionally, if you have a sore throat that is severe, lasts more than 2 days, or is accompanied by fever, headache, rash, nausea, or vomiting, consult your doctor promptly.
Before using this product, consult your doctor if you have any of the following conditions: liver disease, heart disease, high blood pressure, thyroid disease, diabetes, glaucoma, or chronic breathing problems. If you experience nervousness, dizziness, sleeplessness, worsening pain, nasal congestion, cough, or fever lasting more than the specified time, stop use and contact your doctor, as these may indicate a serious condition.
Overdose
Taking more than the recommended doses of Vicks Dayquil or Nyquil Severe Honey can lead to severe liver damage. For adults, this means exceeding 4 doses (30 mL each) in a 24-hour period, while for children, it means taking more than 4 doses (15 mL each) in the same timeframe.
To prevent accidental ingestion and potential overdose, always keep these products out of reach of children. If you suspect an overdose, look for signs such as nausea, vomiting, or unusual tiredness. Seek medical help immediately if you notice any of these symptoms or if you believe an overdose has occurred.
Pregnancy Use
If you are pregnant or breastfeeding, it is important to consult with a healthcare professional before using Vicks Dayquil Nyquil Severe Honey or any similar products. This ensures that you receive personalized advice regarding the safety and potential risks associated with these medications during this sensitive time. Always prioritize your health and the health of your baby by seeking professional guidance.
Lactation Use
If you are breastfeeding, it is important to consult with a healthcare professional before using products like Vicks Dayquil or Nyquil Severe, as their effects on breast milk and your infant are not fully established. Always prioritize your health and your baby's well-being by seeking guidance from a qualified expert.
Pediatric Use
For children aged 6 to under 12 years, you can give 15 mL of Vicks Dayquil Nyquil Severe Honey every 4 hours. However, for children aged 4 to under 6 years, you should only use this product if directed by a doctor, and it is not safe for children under 4 years. Be cautious not to exceed 4 doses (15 mL each) in a 24-hour period, as this is the maximum daily amount.
While using this product, be aware that excitability may occur, especially in children. If your child's pain, nasal congestion, or cough worsens or lasts more than 5 days, stop using the product and consult a doctor.
Geriatric Use
When using Vicks Dayquil Nyquil Severe Honey or Vicks Dayquil Severe Nyquil Severe Honey Flavor, it's important to note that there are no specific guidelines or dosage adjustments provided for older adults. This means that while the product may be safe for use, you should exercise caution and consult with a healthcare professional before starting any new medication, especially if you have underlying health conditions or are taking other medications. Always follow the recommended dosage on the label and monitor for any unusual side effects.
Renal Impairment
When using Vicks Dayquil Nyquil Severe Honey or Vicks Dayquil Severe Nyquil Severe Honey Flavor, it's important to note that there is no specific information available regarding dosage adjustments or safety considerations for individuals with kidney problems. This means that if you have renal impairment, you should consult your healthcare provider before using these products to ensure they are safe for you. Always prioritize your health and seek professional advice when managing medications.
Hepatic Impairment
If you are considering using Vicks Dayquil Nyquil Severe Honey or Vicks Dayquil Severe Nyquil Severe Honey Flavor, it's important to be aware of the potential risks to your liver. Both products contain acetaminophen, which can cause severe liver damage if you exceed the recommended dosage. For adults, this means not taking more than 4 doses (30 mL each) in 24 hours, and for children, not more than 4 doses (15 mL each). Additionally, combining these products with other medications that contain acetaminophen or consuming 3 or more alcoholic drinks daily while using them can increase the risk of liver damage.
If you have liver disease, please consult your doctor before using these products to ensure your safety. Always follow the dosage instructions carefully to protect your liver health.
Drug Interactions
When using Vicks Dayquil Nyquil Severe Honey, it's important to be cautious about potential interactions with other medications. Taking this product with other drugs that contain acetaminophen can significantly increase the risk of severe liver damage, especially if you exceed the recommended dosage. Additionally, if you are on warfarin, a blood-thinning medication, combining it with this product may heighten the risk of bleeding. Always consult your doctor or pharmacist before starting this medication, especially if you are taking warfarin or any other medications, to ensure your safety and avoid serious complications.
Storage and Handling
You should store Vicks Dayquil Nyquil Severe Honey at a temperature not exceeding 25°C (77°F). It's important to keep the product away from refrigeration, as this can affect its effectiveness.
When handling the liquid, ensure that the cap is tightly closed after each use to maintain its quality. For disposal, follow local regulations for liquid medications, as improper disposal can harm the environment.
FAQ
What is VICKS DayQuil™ SEVERE HONEY used for?
VICKS DayQuil™ SEVERE HONEY temporarily relieves common cold and flu symptoms such as nasal congestion, cough, headache, and fever.
What is VICKS® NyQuil™ SEVERE HONEY FLAVOR used for?
VICKS® NyQuil™ SEVERE HONEY FLAVOR is designed for nighttime relief of cold and flu symptoms, including cough and nasal congestion, helping you sleep.
What are the active ingredients in VICKS DayQuil™ SEVERE HONEY?
It contains Acetaminophen, Dextromethorphan HBr, Guaifenesin, and Phenylephrine HCl.
What are the active ingredients in VICKS® NyQuil™ SEVERE HONEY FLAVOR?
It contains acetaminophen, dextromethorphan HBr, doxylamine succinate, and phenylephrine HCl.
How should I take VICKS DayQuil™ SEVERE HONEY?
Adults and children 12 years and over should take 30 mL every 4 hours, while children 6 to under 12 years should take 15 mL every 4 hours.
What is the recommended dosage for adults and children 12 years and over for VICKS® NyQuil™ SEVERE HONEY FLAVOR?
The recommended dosage is 30 mL every 4 hours.
Are there any warnings associated with VICKS DayQuil™ SEVERE HONEY?
Yes, do not exceed 4 doses in 24 hours, and avoid using it with other drugs containing acetaminophen.
Are there any contraindications for using VICKS® NyQuil™ SEVERE HONEY FLAVOR?
Do not use with any other drug containing acetaminophen or if you are taking a prescription monoamine oxidase inhibitor (MAOI).
Can I use VICKS DayQuil™ SEVERE HONEY if I am pregnant or breastfeeding?
If you are pregnant or breastfeeding, consult a health professional before use.
What should I do if I experience a severe skin reaction?
If you notice symptoms like skin reddening, blisters, or rash, stop use and seek medical help immediately.
What are the side effects of VICKS DayQuil™ SEVERE HONEY?
Possible side effects include drowsiness, dizziness, and excitability, especially in children.
What precautions should I take when using VICKS® NyQuil™ SEVERE HONEY FLAVOR?
Avoid alcoholic drinks, be cautious when driving or operating machinery, and consult a doctor if you have liver disease or other health conditions.
What should I do if my symptoms do not improve?
If pain, nasal congestion, or cough worsens or lasts more than 5 days for children or 7 days for adults, consult a doctor.
Is there a risk of liver damage with VICKS DayQuil™ SEVERE HONEY?
Yes, severe liver damage may occur if you take more than the recommended doses or consume alcohol while using this product.
Who should avoid using VICKS DayQuil™ SEVERE HONEY?
Avoid use if you are taking a prescription monoamine oxidase inhibitor (MAOI) or if you have liver disease.
What should I do in case of an overdose?
In case of overdose, get medical help or contact a Poison Control Center right away.
Uses and Indications
This drug is indicated for the temporary relief of common cold and flu symptoms, including:
Nasal congestion
Sinus congestion and pressure
Cough due to minor throat and bronchial irritation
Cough to help facilitate sleep
Minor aches and pains
Headache
Fever
Sore throat
Runny nose and sneezing
Reduction of swelling in nasal passages
Temporary restoration of freer breathing through the nose
Promotion of nasal and/or sinus drainage
Limitations of Use: No teratogenic or nonteratogenic effects have been mentioned.
Dosage and Administration
The recommended dosage for Vicks Dayquil Nyquil Severe Honey is as follows:
For adults and children aged 12 years and older, the dosage is 30 mL every 4 hours. For children aged 6 to under 12 years, the dosage is 15 mL every 4 hours. It is important to note that the product should not be used in children aged 4 to under 6 years unless directed by a physician, and it is contraindicated for children under 4 years of age.
Healthcare professionals should advise patients to take the medication only as directed and to utilize the dose cup provided with the product. Additionally, it is crucial to emphasize that no more than 4 doses should be taken within a 24-hour period to avoid potential overdose.
Contraindications
Do not use this product in conjunction with any other drug containing acetaminophen, whether prescription or nonprescription. If there is uncertainty regarding the presence of acetaminophen in another medication, consultation with a doctor or pharmacist is advised.
This product is contraindicated in patients currently taking a prescription monoamine oxidase inhibitor (MAOI), which includes certain medications for depression, psychiatric or emotional conditions, or Parkinson's disease. Additionally, it should not be used for 2 weeks following the discontinuation of an MAOI. If there is any doubt about whether a prescription drug contains an MAOI, a healthcare professional should be consulted prior to use.
The product should not be used to induce sleepiness in children.
Warnings and Precautions
Severe liver damage may occur with the use of this product, which contains acetaminophen, if the following conditions are met: an adult takes more than 4 doses (30 mL each) in 24 hours, a child takes more than 4 doses (15 mL each) in 24 hours, it is taken with other drugs containing acetaminophen, or an adult consumes 3 or more alcoholic drinks daily while using this product.
Allergy Alert
Acetaminophen may cause severe skin reactions, which can manifest as skin reddening, blisters, or rash. If any skin reaction occurs, the user should stop use and seek medical help immediately.
Sore Throat Warning
If a sore throat is severe, persists for more than 2 days, or is accompanied or followed by fever, headache, rash, nausea, or vomiting, the user should consult a doctor promptly.
General Precautions
Before using this product, individuals should consult a doctor if they have any of the following conditions:
Liver disease
Heart disease
High blood pressure
Thyroid disease
Diabetes
Glaucoma
Cough that occurs with excessive phlegm (mucus)
Breathing problems or chronic cough associated with smoking, asthma, chronic bronchitis, or emphysema
Trouble urinating due to an enlarged prostate gland
Additionally, individuals should ask a doctor or pharmacist before use if they are taking:
Sedatives or tranquilizers
The blood-thinning drug warfarin
Monitoring Requirements
No specific laboratory tests are mentioned for monitoring.
Emergency Medical Help Instructions
In the event of a skin reaction, the user should stop use and seek medical help immediately.
Stop Taking and Call Your Doctor Instructions
Users should stop use and consult a doctor if they experience:
Nervousness, dizziness, or sleeplessness
Worsening pain, nasal congestion, or cough lasting more than 5 days (children) or 7 days (adults)
Fever that worsens or lasts more than 3 days
Redness or swelling
New symptoms
A cough that returns or occurs with a rash or headache that lasts
These symptoms could indicate a serious condition.
Side Effects
Severe liver damage may occur in patients taking this product containing acetaminophen if the following conditions are met: adults exceed 4 doses (30 mL each) in 24 hours, children exceed 4 doses (15 mL each) in 24 hours, the product is taken with other drugs containing acetaminophen, or adults consume 3 or more alcoholic drinks daily while using this product.
Patients may experience severe skin reactions due to acetaminophen, which can manifest as skin reddening, blisters, or rash. In the event of a skin reaction, it is imperative to stop use and seek medical assistance immediately.
Marked drowsiness and excitability, particularly in children, may occur when using this product. Patients are advised to avoid alcoholic beverages, as well as to exercise caution when driving or operating machinery, due to the potential for increased drowsiness when combined with alcohol, sedatives, or tranquilizers.
Patients should consult a healthcare professional before using this product if they have any of the following conditions: liver disease, heart disease, high blood pressure, thyroid disease, diabetes, glaucoma, a cough that produces excessive phlegm, or a chronic cough associated with smoking, asthma, chronic bronchitis, or emphysema. Additionally, those experiencing trouble urinating due to an enlarged prostate gland should seek medical advice prior to use.
Patients are also advised to stop use and consult a doctor if they experience nervousness, dizziness, sleeplessness, worsening pain, nasal congestion, or cough lasting more than 5 days in children or 7 days in adults, fever lasting more than 3 days, redness or swelling, new symptoms, or if a cough recurs with a rash or headache that persists. These symptoms may indicate a serious condition.
Drug Interactions
Acetaminophen, a key ingredient in Vicks Dayquil Nyquil Severe Honey and Vicks Dayquil Severe Nyquil Severe Honey Flavor, may pose a risk of severe liver damage when taken concurrently with other medications containing acetaminophen or when exceeding the recommended dosage.
Additionally, the use of these products in conjunction with warfarin, an anticoagulant, may heighten the risk of bleeding. It is advisable for patients to consult a healthcare professional prior to using these products if they are currently taking warfarin or any other blood-thinning medications.
Pediatric Use
Children aged 6 to under 12 years may be administered 15 mL of Vicks Dayquil Nyquil Severe Honey or Vicks Dayquil Severe Nyquil Severe Honey Flavor every 4 hours. For children aged 4 to under 6 years, use is not recommended unless directed by a doctor. The product is not indicated for children under 4 years of age.
Caution is advised regarding liver health; a child should not exceed 4 doses (15 mL each) within a 24-hour period, as this is the maximum daily amount for these products.
Excitability may occur, particularly in children. Parents or caregivers should discontinue use and consult a doctor if a child's pain, nasal congestion, or cough worsens or persists for more than 5 days.
Geriatric Use
No specific information regarding geriatric use, dosage adjustments, safety concerns, or special precautions for elderly patients is provided in the inserts for Vicks Dayquil Nyquil Severe Honey and Vicks Dayquil Severe Nyquil Severe Honey Flavor. Therefore, healthcare professionals should exercise caution and consider individual patient factors when prescribing these medications to geriatric patients. Monitoring for potential adverse effects is advisable, given the lack of specific data for this population.
Pregnancy
If pregnant or breast-feeding, patients are advised to consult a health professional before using Vicks Dayquil Nyquil Severe Honey and Vicks Dayquil Severe Nyquil Severe Honey Flavor. There is limited data on the safety of these products during pregnancy, and potential risks to fetal outcomes have not been established. Therefore, healthcare providers should evaluate the benefits and risks before recommending these medications to pregnant patients.
Lactation
Lactating mothers are advised to consult a healthcare professional before using Vicks Dayquil Nyquil Severe Honey or Vicks Dayquil Severe Nyquil Severe Honey Flavor. There is no specific data provided regarding the excretion of these products in breast milk or their effects on breastfed infants. Therefore, caution is recommended during lactation.
Renal Impairment
Patients with renal impairment have no specific information regarding dosage adjustments, monitoring, or safety considerations provided in the inserts for Vicks Dayquil Nyquil Severe Honey and Vicks Dayquil Severe Nyquil Severe Honey Flavor. As such, healthcare professionals should exercise caution when prescribing these products to patients with reduced kidney function, given the absence of guidance on their use in this population. It is advisable to consider individual patient circumstances and monitor for any potential adverse effects.
Hepatic Impairment
Patients with hepatic impairment should exercise caution when using this product, which contains acetaminophen. Severe liver damage may occur if the following conditions are met:
An adult takes more than 4 doses (30 mL each) in 24 hours, which is the maximum daily amount for this product.
A child takes more than 4 doses (15 mL each) in 24 hours, which is the maximum daily amount for this product.
The product is taken concurrently with other medications containing acetaminophen.
An adult consumes 3 or more alcoholic drinks daily while using this product.
It is advised that patients with liver disease consult a healthcare professional before using this product to assess the risks and determine appropriate usage. Monitoring of liver function may be warranted in these patients to prevent potential hepatotoxicity.
Overdosage
Severe liver damage may occur in adults who exceed 4 doses (30 mL each) within a 24-hour period, which is the maximum recommended daily amount for this product. Similarly, children are at risk of severe liver damage if they take more than 4 doses (15 mL each) in a 24-hour period.
In the event of an overdose, it is crucial to seek immediate medical attention. Monitoring for symptoms of liver damage is essential, which may include jaundice, dark urine, abdominal pain, and confusion.
To prevent accidental ingestion and potential overdose, it is imperative to keep this product out of reach of children.
Nonclinical Toxicology
Teratogenic Effects
No specific teratogenic effects have been reported for Vicks Dayquil Nyquil Severe Honey or Vicks Dayquil Severe Nyquil Severe Honey Flavor. However, it is advised that individuals who are pregnant or breastfeeding consult a health professional prior to use.
Non-Teratogenic Effects
There is no information available regarding non-teratogenic effects for either formulation.
Animal Toxicology
No details regarding animal pharmacology and toxicology have been provided for the products in question.
Storage and Handling
Vicks Dayquil Nyquil Severe Honey and Vicks Dayquil Severe Nyquil Severe Honey Flavor are both supplied in liquid form.
These products should be stored at a temperature not exceeding 25°C. It is important to avoid refrigeration to maintain product integrity.
Product Labels
The table below lists all over-the-counter labels containing acetaminophen, guaifenesin, dextromethorphan hydrobromide, and phenylephrine hydrochloride. Use it to compare dosage forms, strengths, and uses across products.
More Details | |||||
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The Procter & Gamble Manufacturing Company | Liquid | Oral |
| 2020 | |
Indications
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The Procter & Gamble Manufacturing Company | Liquid | Oral |
| 2020 | |
Indications
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