Symptom checker
Select audience type

Switch between content for healthcare professionals (PRO) and general audience (GEN).

ADD CONDITION

items per page

Multi-Symptom Mapap Cold Formula

Last content change checked dailysee data sync status

Active ingredients
  • Acetaminophen 325 mg
  • Dextromethorphan Hydrobromide 10 mg
  • Phenylephrine Hydrochloride 5 mg
Other brand names
Drug classes
Sigma-1 Agonist, Uncompetitive N-methyl-D-aspartate Receptor Antagonist, alpha-1 Adrenergic Agonist
Dosage form
Tablet, Film Coated
Route
Oral
Prescription status
OTC (over the counter)
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 2005
Label revision date
December 3, 2025
Drug Information (PDF)
Prescribing information, PDF file
Active ingredients
  • Acetaminophen 325 mg
  • Dextromethorphan Hydrobromide 10 mg
  • Phenylephrine Hydrochloride 5 mg
Other brand names
Drug classes
Sigma-1 Agonist, Uncompetitive N-methyl-D-aspartate Receptor Antagonist, alpha-1 Adrenergic Agonist
Dosage form
Tablet, Film Coated
Route
Oral
Prescription status
OTC (over the counter)
CSA schedule
Not a scheduled drug
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 2005
Label revision date
December 3, 2025
Manufacturer
Major Pharmaceuticals
Registration number
M012
NDC root
0904-5786
Drug Information (PDF)
Prescribing information, PDF file
Packaging Info
Packaging & NDC Codes

If you are a healthcare professional or from the pharmaceutical industry please visit this version.

If you are a consumer or patient please visit this version.

Drug Overview

Mapap® is a multi-symptom cold formula designed to temporarily relieve common cold and flu symptoms. It contains acetaminophen (a pain reliever and fever reducer), dextromethorphan HBr (a cough suppressant), and phenylephrine HCl (a nasal decongestant). This combination helps alleviate minor aches and pains, nasal congestion, headaches, coughs, sore throats, and sinus pressure, while also promoting nasal and sinus drainage and temporarily reducing fever.

This medication is aspirin-free and comes in a package of 24 caplets with a cool blast flavor, making it a convenient option for managing your cold symptoms.

Uses

If you're dealing with the discomfort of a common cold or flu, this medication can help. It temporarily relieves symptoms such as minor aches and pains, nasal congestion, headaches, coughs, sore throats, and sinus congestion and pressure. By helping to clear your nasal passages and promoting drainage in your sinuses, it can make breathing easier when you're feeling under the weather.

Additionally, this medication can temporarily reduce fever, providing you with some relief from the discomfort that often accompanies illness. Remember, it's important to use it as directed to effectively manage your symptoms.

Dosage and Administration

When taking this medication, it's important to follow the instructions carefully. For adults and children aged 12 years and older, you should take 2 caplets every 4 hours. Make sure to swallow the caplets whole; do not crush, chew, or dissolve them. Remember, you should not exceed 10 caplets in a 24-hour period to avoid any potential risks.

If you are considering this medication for a child under 12 years old, it's best to consult a doctor first. Always stick to the recommended dosage to ensure your safety and effectiveness of the treatment.

What to Avoid

You should avoid using this medication if you are currently taking any other drug that contains acetaminophen, whether it's a prescription or over-the-counter product. If you're unsure whether a medication contains acetaminophen, please consult your doctor or pharmacist. Additionally, do not take this medication if you are on a prescription monoamine oxidase inhibitor (MAOI), which is used for certain mental health conditions or Parkinson’s disease, or for two weeks after stopping an MAOI. If you are uncertain about your medications, it's important to ask a healthcare professional. Lastly, do not use this product if you have ever experienced an allergic reaction to it or any of its ingredients.

Side Effects

You should be aware of some important warnings and potential side effects when using this product. It contains acetaminophen, which can cause severe liver damage if you exceed 4,000 mg in 24 hours, take it with other acetaminophen-containing medications, or consume three or more alcoholic drinks daily while using it. Additionally, acetaminophen may lead to serious skin reactions, such as blisters, rash, or skin reddening. If you notice any skin reactions, stop using the product and seek medical help immediately.

It's also important to consult a doctor if you experience nervousness, dizziness, or sleeplessness, or if your pain, nasal congestion, or cough worsens or lasts more than a week. If you have a sore throat that is severe, persists for more than two days, or is accompanied by fever, headache, rash, nausea, or vomiting, seek medical attention promptly. Always talk to your doctor before using this product if you have liver disease, diabetes, heart disease, thyroid disease, high blood pressure, or other specific health conditions.

Warnings and Precautions

This product contains acetaminophen, which can lead to severe liver damage if you take more than 4,000 mg in 24 hours, use it with other acetaminophen-containing medications, or consume three or more alcoholic drinks daily while using it. Be aware that acetaminophen may also cause serious skin reactions, such as blisters or rashes. If you notice any skin issues, stop using the product and seek medical help immediately. If you have a severe sore throat that lasts more than two days or is accompanied by fever, headache, rash, nausea, or vomiting, consult your doctor promptly.

Before using this product, it's important to talk to your doctor if you have any of the following conditions: liver disease, diabetes, heart disease, thyroid disease, high blood pressure, difficulty urinating due to prostate enlargement, or a chronic cough. If you are taking the blood thinner warfarin, consult your doctor or pharmacist before use. In case of an overdose, seek emergency medical help or contact a Poison Control Center right away, even if you don't notice any symptoms.

You should stop using this product and call your doctor if you experience nervousness, dizziness, or sleeplessness, if your pain, nasal congestion, or cough worsens or lasts more than seven days, if your fever worsens or lasts more than three days, or if you notice redness or swelling. New symptoms or a returning cough, especially if accompanied by a rash or headache, could indicate a serious condition that requires medical attention.

Overdose

If you suspect an overdose, it’s important to seek medical help immediately or contact a Poison Control Center. This is crucial for both adults and children, even if you don’t see any signs or symptoms of an overdose.

Signs of an overdose can vary, but they may include unusual drowsiness, confusion, or difficulty breathing. Remember, acting quickly can make a significant difference, so don’t hesitate to get help right away.

Pregnancy Use

If you are pregnant or breastfeeding, it’s important to consult with a healthcare professional before using this medication. They can provide guidance on whether it’s safe for you and your baby. Always prioritize your health and the health of your child by seeking expert advice.

Lactation Use

If you are pregnant or breastfeeding, it’s important to consult with a healthcare professional before using any medication. This ensures that you understand any potential risks and can make informed decisions about your health and the health of your baby. Always prioritize open communication with your doctor regarding your breastfeeding journey.

Pediatric Use

If you are considering this medication for your child, it's important to consult with a doctor if your child is under 12 years old. For children aged 12 and older, the recommended dosage is 2 caplets every 4 hours, but make sure not to exceed 10 caplets in a 24-hour period.

In the event of an overdose, seek medical help immediately for both adults and children, even if there are no noticeable signs or symptoms. Your child's safety is paramount, so always follow these guidelines closely.

Geriatric Use

When it comes to using this medication in older adults, there is no specific information available about dosage adjustments, safety concerns, or special precautions. This means that if you or a loved one is an older adult, it’s important to consult with a healthcare provider for personalized advice. They can help determine the best approach based on individual health needs and any other medications being taken. Always prioritize open communication with your healthcare team to ensure safe and effective treatment.

Renal Impairment

If you have kidney problems, it's important to consult your doctor before using this medication, especially if you experience difficulty urinating due to an enlarged prostate gland. Your healthcare provider can help determine if this medication is safe for you and may suggest adjustments to your dosage or monitoring based on your kidney function. Always prioritize open communication with your doctor regarding your kidney health and any medications you are considering.

Hepatic Impairment

If you have liver problems, it's important to be cautious when using products that contain acetaminophen. Taking more than 4,000 mg of acetaminophen in a 24-hour period, using it alongside other medications that also contain acetaminophen, or consuming three or more alcoholic drinks daily while using this product can lead to severe liver damage.

Before using this product, you should consult your doctor if you have liver disease. They can provide guidance on safe usage and any necessary adjustments to your dosage. Your health and safety are paramount, so don’t hesitate to seek professional advice.

Drug Interactions

It's important to have open conversations with your healthcare provider about any medications or tests you may be taking. While there are no specific drug interactions or laboratory test interactions noted for this medication, your healthcare provider can help ensure that everything you are taking works well together and is safe for you.

Always feel free to ask questions and share your complete list of medications and any lab tests you may be undergoing. This way, you can receive the best possible care tailored to your needs.

Storage and Handling

To ensure the best quality and safety of your product, store it at room temperature, ideally around 25°C (77°F). It can safely be kept in a range from 15°C to 30°C (59°F to 86°F). Always check the outer package before use; if it is opened or if the blister is torn or broken, do not use the product. Additionally, make sure to look for the expiration date and lot number on the end flap to confirm its validity.

By following these simple storage and handling guidelines, you can help maintain the product's effectiveness and ensure your safety.

Additional Information

If you are considering using this medication, it is important to take it orally as directed. If you are pregnant or breastfeeding, be sure to consult with a healthcare professional before using this medication to ensure it is safe for you and your baby.

Additionally, it's crucial to be aware of the potential for medicine abuse, especially among teens. For more information on this topic, you can visit www.StopMedicineAbuse.org.

FAQ

What is Mapap®?

Mapap® is a multi-symptom cold formula that temporarily relieves common cold and flu symptoms.

What are the active ingredients in Mapap®?

Mapap® contains acetaminophen (325 mg), a pain reliever and fever reducer; dextromethorphan HBr (10 mg), a cough suppressant; and phenylephrine HCl (5 mg), a nasal decongestant.

What symptoms does Mapap® relieve?

It temporarily relieves minor aches and pains, nasal congestion, headache, cough, sore throat, and sinus congestion and pressure.

What is the recommended dosage for adults and children 12 years and over?

Take 2 caplets every 4 hours, swallowing them whole. Do not exceed 10 caplets in 24 hours.

Can children under 12 years use Mapap®?

Children under 12 years should ask a doctor before use.

What should I do in case of overdose?

In case of overdose, seek medical help or contact a Poison Control Center immediately.

Are there any warnings associated with Mapap®?

Yes, it contains acetaminophen, which can cause severe liver damage if taken in excess or with other acetaminophen-containing drugs. It may also cause severe skin reactions.

What should I do if I experience severe side effects?

Stop use and consult a doctor if you experience nervousness, dizziness, sleeplessness, or if symptoms worsen or new symptoms occur.

Is Mapap® safe to use during pregnancy or breastfeeding?

If you are pregnant or breastfeeding, consult a health professional before use.

How should Mapap® be stored?

Store at 25°C (77°F), with permitted excursions between 15°-30°C (59°-86°F).

Packaging Info

Below are the non-prescription pack sizes of Multi-Symptom Mapap Cold Formula (acetaminophen, dextromethorphan hbr, phenylephrine hcl). Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Multi-Symptom Mapap Cold Formula.
Details

Drug Information (PDF)

This file contains official product information for Multi-Symptom Mapap Cold Formula, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Description

No description information is available for the specified drug.

Uses and Indications

This drug is indicated for the temporary relief of common cold and flu symptoms, including minor aches and pains, nasal congestion, headache, cough, sore throat, and sinus congestion and pressure. It aids in clearing nasal passages and promotes nasal and sinus drainage. Additionally, this drug temporarily reduces fever.

There are no teratogenic or nonteratogenic effects associated with this drug.

Dosage and Administration

Adults and children aged 12 years and older are instructed to take 2 caplets orally every 4 hours as needed. It is essential that the caplets are swallowed whole; they should not be crushed, chewed, or dissolved. The maximum allowable dosage is 10 caplets within a 24-hour period. For children under 12 years of age, it is recommended to consult a physician before administration.

Contraindications

Use of this product is contraindicated in the following situations:

  • Co-administration with any other drug containing acetaminophen, whether prescription or nonprescription, due to the risk of acetaminophen overdose. If there is uncertainty regarding the presence of acetaminophen in other medications, consultation with a healthcare professional is advised.

  • Concurrent use with prescription monoamine oxidase inhibitors (MAOIs) or within 2 weeks of discontinuing an MAOI, as this may lead to serious drug interactions. Patients should verify with a healthcare provider if their current medications include an MAOI.

  • History of allergic reactions to this product or any of its ingredients, as this may result in severe hypersensitivity reactions.

Warnings and Precautions

This product contains acetaminophen, which carries specific warnings and precautions that healthcare professionals should be aware of to ensure safe use.

Liver Warning Severe liver damage may occur if the patient exceeds 4,000 mg of acetaminophen in a 24-hour period, uses other medications containing acetaminophen concurrently, or consumes three or more alcoholic drinks daily while using this product. It is crucial to monitor the total daily intake of acetaminophen and assess the patient's alcohol consumption to mitigate the risk of liver injury.

Allergy Alert Acetaminophen may lead to severe skin reactions, which can manifest as blisters, rash, or skin reddening. If any of these symptoms occur, the patient should discontinue use immediately and seek medical assistance.

Sore Throat Warning In cases of severe sore throat that persists for more than two days or is accompanied by fever, headache, rash, nausea, or vomiting, it is imperative to consult a physician promptly.

General Precautions Healthcare professionals should advise patients to consult a doctor before using this product if they have any of the following conditions: liver disease, diabetes, heart disease, thyroid disease, high blood pressure, difficulty urinating due to prostate enlargement, or a persistent or chronic cough associated with smoking, asthma, or emphysema. Additionally, patients taking the anticoagulant warfarin should seek guidance from a doctor or pharmacist prior to use.

Emergency Medical Help In the event of an overdose, immediate medical attention is essential. Patients or caregivers should contact a Poison Control Center or seek emergency medical help without delay, even if no symptoms are apparent, as prompt intervention is critical for both adults and children.

Discontinuation of Use Patients should stop taking this product and consult a healthcare provider if they experience nervousness, dizziness, or sleeplessness; if pain, nasal congestion, or cough worsens or persists beyond seven days; if fever worsens or lasts more than three days; if redness or swelling occurs; if new symptoms develop; or if a cough recurs or is accompanied by a rash or headache lasting longer than expected. These symptoms may indicate a serious underlying condition that requires further evaluation.

Side Effects

Patients using this product should be aware of several important warnings and potential adverse reactions.

Severe liver damage may occur if patients exceed 4,000 mg of acetaminophen in a 24-hour period, use other medications containing acetaminophen concurrently, or consume three or more alcoholic drinks daily while using this product. Additionally, acetaminophen may cause severe skin reactions, which can manifest as blisters, rash, or skin reddening. If any skin reaction occurs, patients are advised to discontinue use immediately and seek medical assistance.

In cases of severe sore throat that persists for more than two days or is accompanied by fever, headache, rash, nausea, or vomiting, patients should consult a healthcare professional promptly.

Patients are also advised to stop use and contact a doctor if they experience nervousness, dizziness, or sleeplessness; if pain, nasal congestion, or cough worsens or lasts more than seven days; if fever worsens or lasts more than three days; if redness or swelling is present; if new symptoms arise; or if a cough recurs or occurs with a rash or headache that lasts, as these may indicate a serious condition.

Before using this product, patients should consult a doctor if they have liver disease, diabetes, heart disease, thyroid disease, high blood pressure, difficulty urinating due to prostate enlargement, or a persistent or chronic cough associated with smoking, asthma, or emphysema. Additionally, patients should seek advice from a doctor or pharmacist if they are taking the blood-thinning medication warfarin.

Drug Interactions

There are currently no documented drug interactions associated with this medication. Additionally, there is no information available regarding interactions with laboratory tests. As such, no specific recommendations for dosage adjustments or monitoring are warranted at this time.

Packaging & NDC

Below are the non-prescription pack sizes of Multi-Symptom Mapap Cold Formula (acetaminophen, dextromethorphan hbr, phenylephrine hcl). Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Multi-Symptom Mapap Cold Formula.
Details

Pediatric Use

Pediatric patients under 12 years of age should consult a healthcare professional before use. For those aged 12 years and older, the recommended dosing is 2 caplets every 4 hours, with a maximum of 10 caplets in a 24-hour period.

In the event of an overdose, it is essential to seek prompt medical attention for both adults and pediatric patients, even if no signs or symptoms are immediately apparent.

Geriatric Use

Elderly patients may not have specific information regarding the use of this medication, including dosage adjustments, safety concerns, or special precautions. Therefore, healthcare providers should exercise caution when prescribing this medication to geriatric patients. It is advisable to monitor these patients closely for any adverse effects or changes in therapeutic response, given the lack of targeted data for this population.

Pregnancy

Pregnant patients and those who are breastfeeding should consult a healthcare professional prior to using this medication. It is important to assess the potential risks and benefits, as well as any available data regarding fetal outcomes and lactation. Healthcare providers can offer guidance tailored to individual circumstances, ensuring the safety of both the patient and the developing fetus or nursing infant.

Lactation

Lactating mothers are advised to consult a health professional prior to using this medication. There is currently no available data regarding the excretion of this medication in human breast milk or its effects on breastfed infants. Therefore, caution is recommended when administering this medication to lactating individuals.

Renal Impairment

Patients with renal impairment should consult a healthcare professional prior to use, particularly if they experience difficulty in urination due to enlargement of the prostate gland. It is essential to assess renal function and consider potential dosing adjustments or monitoring requirements based on the degree of impairment.

Hepatic Impairment

Patients with hepatic impairment should exercise caution when using this product, as it contains acetaminophen, which is associated with the risk of severe liver damage. It is critical for patients to adhere to the following guidelines to minimize the risk of hepatotoxicity:

  • Patients should not exceed a maximum dosage of 4,000 mg of acetaminophen within a 24-hour period.

  • Concurrent use with other medications containing acetaminophen is contraindicated, as this may lead to unintentional overdose and increased risk of liver injury.

  • Consumption of three or more alcoholic drinks per day while using this product is not recommended, as it may exacerbate the risk of liver damage.

Additionally, patients with a known history of liver disease should consult a healthcare professional prior to using this product to ensure safety and appropriateness of treatment. Regular monitoring of liver function may be warranted in patients with compromised liver function to detect any potential adverse effects early.

Overdosage

In the event of an overdose, it is imperative to seek immediate medical assistance or contact a Poison Control Center without delay. Prompt medical intervention is crucial for both adults and children, even in the absence of noticeable signs or symptoms.

Healthcare professionals should be aware that the lack of immediate symptoms does not preclude the potential for serious health consequences. Therefore, it is essential to monitor the patient closely and provide appropriate care as needed.

Nonclinical Toxicology

No information is available regarding teratogenic effects. Additionally, there is no information provided concerning non-teratogenic effects. The insert does not contain any details related to nonclinical toxicology. Furthermore, there is no information regarding animal pharmacology and toxicology.

Postmarketing Experience

Postmarketing experience has revealed reports of severe skin reactions associated with acetaminophen. These reactions include symptoms such as blisters, rash, and skin reddening. These events have been reported voluntarily or identified through surveillance programs.

Patient Counseling

Patients should be advised to seek immediate medical assistance or contact a Poison Control Center in the event of an overdose, as prompt medical attention is crucial for both adults and children, even if no signs or symptoms are initially apparent.

It is important to emphasize that patients should not exceed the recommended dosage of the medication.

Healthcare providers should encourage patients to consult with their doctor prior to use if they have any of the following conditions: liver disease, diabetes, heart disease, thyroid disease, high blood pressure, difficulty urinating due to an enlarged prostate gland, or a persistent or chronic cough associated with smoking, asthma, or emphysema. Additionally, patients should be advised to seek medical advice if they have a cough that produces excessive phlegm (mucus).

Furthermore, patients taking the blood-thinning medication warfarin should be instructed to consult with their doctor or pharmacist before using this product to ensure safety and avoid potential interactions.

Storage and Handling

The product is supplied in a tamper-evident package. It should not be used if the outer package is opened or if the blister is torn or broken. The recommended storage temperature is 25°C (77°F), with permissible excursions between 15°-30°C (59°-86°F). Healthcare professionals are advised to check the end flap of the package for the expiration date and lot number to ensure product integrity and safety.

Additional Clinical Information

Patients should be informed that the medication is administered orally. Clinicians are advised to counsel patients regarding the importance of consulting a health professional if they are pregnant or breastfeeding before using the medication. Additionally, resources are available for understanding the risks of medicine abuse among teens, specifically at www.StopMedicineAbuse.org. No further information is available regarding laboratory tests or postmarketing experiences.

Drug Information (PDF)

This file contains official product information for Multi-Symptom Mapap Cold Formula, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Data Generation & Sources

This page was automatically generated and is maintained by the AllDrugs AI Data-Science Team. It was built from the FDA Structured Product Label (DailyMed) for Multi-Symptom Mapap Cold Formula, retrieved by a validated AI data-extraction workflow.

All FDA-listed dosage forms and strengths are shown in the Packaging & NDC Codes section above. Regulatory status appears in the Summary Information panel above and was verified in the FDA National Drug Code directory and the NSDE NDC Directory daily file.

Note: an automated daemon monitors NSDE checksums; when the record for this NDC changes, the new file is pulled instantly and this page is refreshed.

No human clinician has reviewed this version.

Learn more in our Editorial Policy

Last AI update:

Primary FDA sources:

Orange Book data shown on this page are limited to Regulatory Status (Rx), Established Pharmacologic Class (EPC), and Mechanism of Action (MoA).

Regulatory data notice: Information on this page is reproduced verbatim from FDA public databases (NSDE, Orange Book, Purple Book, DailyMed SPL). NDA/ANDA drugs are FDA-approved, BLA biologics are FDA-licensed. Inclusion alone does not guarantee current market availability or imply FDA endorsement.

Medical disclaimer: This AI-generated content is provided for educational purposes only and does not constitute medical advice. Always consult a licensed healthcare professional for diagnosis or treatment decisions.