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Asperflex Advance

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Active ingredients
  • Camphor (synthetic) 86.24 mg
  • Menthol 166.92 mg
  • Methyl Salicylate 278.2 mg
Other brand names
Dosage form
Patch
Routes
  • Percutaneous
  • Topical
  • Transdermal
Prescription status
OTC (over the counter)
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 2021
Label revision date
October 1, 2025
Drug Information (PDF)
Prescribing information, PDF file
Active ingredients
  • Camphor (synthetic) 86.24 mg
  • Menthol 166.92 mg
  • Methyl Salicylate 278.2 mg
Other brand names
Dosage form
Patch
Routes
  • Percutaneous
  • Topical
  • Transdermal
Prescription status
OTC (over the counter)
CSA schedule
Not a scheduled drug
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 2021
Label revision date
October 1, 2025
Manufacturer
Akron Pharma Inc.
Registration number
M017
NDC root
71399-4458
Drug Information (PDF)
Prescribing information, PDF file
Packaging Info
Packaging & NDC Codes

If you are a healthcare professional or from the pharmaceutical industry please visit this version.

If you are a consumer or patient please visit this version.

Drug Overview

This medication is designed to provide temporary relief from minor aches and pains in your muscles and joints. It can be particularly helpful for conditions such as arthritis, simple backache, strains, bruises, and sprains. If you're experiencing discomfort from any of these issues, this drug may be a suitable option to help ease your pain.

Uses

If you're dealing with minor aches and pains in your muscles and joints, this medication can help provide temporary relief. It's effective for discomfort associated with various conditions, including arthritis, simple backaches, strains, bruises, and sprains.

You can rely on this treatment to ease your pain and help you get back to your daily activities. Remember, it's designed for short-term use to manage these specific types of discomfort.

Dosage and Administration

To use this medication effectively, start by cleaning and drying the area of your skin that is affected. Once the area is ready, carefully remove the patch from its protective film. You can then apply the patch to the affected area, but make sure to do this no more than 3 to 4 times a day. Remember to remove the patch after it has been on your skin for no longer than 8 hours.

If you are applying this medication to a child under 12 years old, it’s important to consult a doctor first to ensure it’s safe and appropriate for their use.

What to Avoid

It's important to use this product safely to avoid any potential issues. You should not use it on wounds or damaged skin, with a heating pad, or if you are allergic to any of its ingredients. Additionally, when using this product, make sure to avoid contact with your eyes, mucous membranes, or any rashes, and do not apply a tight bandage over the area.

By following these guidelines, you can help ensure a safer experience with the product. If you have any concerns or questions about its use, please consult a healthcare professional.

Side Effects

When using this product, it's important to be aware of potential side effects. You should stop using it and consult a doctor if you experience a rash, itching, or excessive skin irritation. Additionally, if your condition worsens, symptoms persist for more than 7 days, or if symptoms clear up and then return within a few days, seek medical advice.

If you have a history of allergic reactions to aspirin or salicylates, consult your doctor before use. This product is for external use only and should not be applied to wounds or damaged skin, nor should it be used with a heating pad. Always avoid contact with your eyes and mucous membranes, and do not bandage the area tightly. If you are pregnant or breastfeeding, it's best to consult a healthcare professional before using this product. Keep it out of reach of children, and if swallowed, seek medical help immediately.

Warnings and Precautions

This product is for external use only, so please avoid applying it to wounds or damaged skin. If you have a history of allergic reactions to aspirin or salicylates, it's important to consult your doctor before using this product. Always use it as directed and steer clear of contact with your eyes, mucous membranes, or any rashes. Additionally, do not use it with a heating pad or bandage tightly.

If you notice any rash, itching, or excessive skin irritation, or if your condition worsens or does not improve after 7 days, stop using the product and contact your doctor. If symptoms clear up and then return within a few days, reach out to your healthcare provider as well. Keep this product out of reach of children, and if it is swallowed, seek medical help or contact a Poison Control Center immediately.

Overdose

If you or someone else has swallowed too much of a medication, it’s important to seek medical help immediately. You can do this by contacting a Poison Control Center or going to the nearest emergency room. Acting quickly can make a significant difference in the outcome.

Signs of an overdose can vary, but they may include unusual drowsiness, confusion, or difficulty breathing. If you notice any of these symptoms, don’t hesitate to get help right away. Remember, it’s always better to be safe and seek assistance if you suspect an overdose.

Pregnancy Use

If you are pregnant or breastfeeding, it’s important to consult with a healthcare professional before using this medication. They can provide guidance on whether it’s safe for you and your baby. Always prioritize your health and the health of your child by seeking expert advice.

Lactation Use

If you are pregnant or breastfeeding, it’s important to consult with a healthcare professional before using any medication. This ensures that you understand any potential risks and can make informed decisions about your health and the health of your baby. Always prioritize open communication with your doctor regarding your breastfeeding journey.

Pediatric Use

If your child is under 12 years old, it's important to consult a doctor before using this medication. For children aged 12 and older, you can apply the medication to the affected area, but be sure to do so no more than 3 to 4 times a day. Always follow these guidelines to ensure your child's safety and well-being.

Geriatric Use

When it comes to using this medication in older adults, there is no specific information available about dosage adjustments, safety concerns, or special precautions. This means that if you or a loved one is an older adult considering this medication, it’s important to consult with a healthcare provider. They can help determine the best approach based on individual health needs and any other medications being taken.

Always keep in mind that older adults may have different responses to medications, so discussing any concerns with a doctor is essential for ensuring safety and effectiveness.

Renal Impairment

If you have kidney problems, it's important to know that the drug insert does not provide specific information about dosage adjustments, special monitoring, or safety considerations for your condition. This means that there are no tailored guidelines for how this medication may affect you if you have renal impairment (kidney issues).

Always consult your healthcare provider for personalized advice and to ensure that any medication you take is safe and appropriate for your health situation. They can help monitor your kidney function and make any necessary adjustments to your treatment plan.

Hepatic Impairment

If you have liver problems, it's important to know that the drug insert does not provide specific information about dosage adjustments, special monitoring, or precautions for your condition. This means that there are no tailored guidelines for how this medication should be used if you have hepatic impairment (issues with liver function).

Before starting any new medication, including this one, you should discuss your liver health with your healthcare provider. They can help determine the best approach for your treatment and ensure your safety.

Drug Interactions

It's important to have open conversations with your healthcare provider about any medications or tests you may be taking. While there are no specific drug interactions or laboratory test interactions noted for this medication, your healthcare provider can help ensure that everything you are taking works well together and is safe for you. Always share your complete list of medications and any recent lab tests to avoid any potential issues. Your health and safety should always come first.

Storage and Handling

To ensure the best performance of your product, store it at room temperature, ideally between 15° and 30°C (59° and 86°F). This temperature range helps maintain the integrity and effectiveness of the device.

When handling the product, make sure to do so in a clean environment to avoid contamination. Always follow any specific instructions provided for use to ensure safety and effectiveness. If you have any questions about disposal or further handling, please refer to the guidelines provided with your product.

Additional Information

You should apply the medication to the affected area using a patch on your skin, but no more than 3 to 4 times a day. Remember to remove the patch after a maximum of 8 hours. If you are pregnant or breastfeeding, it's important to consult a healthcare professional before using this medication.

Keep the medication out of reach of children. If a child accidentally swallows it, seek medical help or contact a Poison Control Center immediately.

FAQ

What is the primary use of this drug?

This drug is used for temporary relief of minor aches and pains of muscles and joints associated with conditions like arthritis, simple backache, strains, bruises, and sprains.

How should adults and children 12 years and older use this product?

Clean and dry the affected area, remove the patch from the film, and apply it to the area not more than 3 to 4 times daily. Remove the patch after a maximum of 8 hours.

What should I do if I am under 12 years of age?

If you are under 12 years of age, consult a doctor before using this product.

Are there any warnings I should be aware of?

This product is for external use only. If you are prone to allergic reactions from aspirin or salicylates, consult a doctor before use.

What should I avoid while using this product?

Avoid using this product on wounds or damaged skin, with a heating pad, and ensure it does not come into contact with your eyes, mucous membranes, or rashes.

What should I do if I experience a rash or excessive skin irritation?

Stop using the product and ask a doctor if rash, itching, or excessive skin irritation develops, or if conditions worsen.

What precautions should I take if I am pregnant or breastfeeding?

If you are pregnant or breastfeeding, ask a health professional before using this product.

How should I store this product?

Store the product at room temperature between 15°-30°C (59°-86°F).

What should I do if the product is swallowed?

Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center immediately.

Packaging Info

Below are the non-prescription pack sizes of Asperflex Advance (camphor, menthol, methyl salicylate). Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Asperflex Advance.
Details

Drug Information (PDF)

This file contains official product information for Asperflex Advance, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Description

No description information is available for the drug.

Uses and Indications

This drug is indicated for the temporary relief of minor aches and pains of muscles and joints associated with various conditions, including arthritis, simple backache, strains, bruises, and sprains.

There are no teratogenic or nonteratogenic effects associated with this drug.

Dosage and Administration

For adults and children aged 12 years and over, the affected area should be cleaned and dried prior to application. The patch must be removed from its protective film and applied directly to the affected area. It is recommended that the patch be applied no more than 3 to 4 times daily. Each patch should be removed from the skin after a maximum application duration of 8 hours.

For children under 12 years of age, it is advised to consult a healthcare professional before use.

Contraindications

The product is contraindicated for use on wounds or damaged skin due to the potential for irritation and delayed healing. It should not be used in conjunction with a heating pad, as this may increase the risk of burns or adverse reactions. Additionally, individuals with known allergies to any ingredients in this product should refrain from use to prevent allergic reactions.

While using this product, it is essential to avoid contact with the eyes, mucous membranes, or rashes, as this may lead to irritation or exacerbation of the condition. Furthermore, tight bandaging is not recommended, as it may impede circulation and cause discomfort.

Warnings and Precautions

For external use only. Healthcare professionals should advise patients to consult a doctor prior to use if they have a history of allergic reactions to aspirin or salicylates.

This product should not be applied to wounds or damaged skin, nor should it be used in conjunction with a heating pad. Additionally, individuals with known allergies to any of the product's ingredients must refrain from using it.

When administering this product, it is imperative to use it strictly as directed. Patients should be cautioned to avoid contact with the eyes, mucous membranes, or any rashes. Furthermore, it is advised not to apply tight bandages over the treated area.

Patients should be instructed to discontinue use and seek medical advice if any of the following occur: rash, itching, or excessive skin irritation; worsening of the condition; persistence of symptoms beyond 7 days; or if symptoms resolve and then recur within a few days.

It is essential to keep this product out of reach of children. In the event of accidental ingestion, immediate medical assistance should be sought, or contact with a Poison Control Center should be made without delay.

Side Effects

Patients should be aware that this product is for external use only. Individuals with a known allergy to aspirin or salicylates are advised to consult a healthcare professional prior to use. The product should not be applied to wounds or damaged skin, nor should it be used in conjunction with a heating pad. Additionally, it is important to avoid contact with the eyes, mucous membranes, or rashes, and to refrain from tightly bandaging the area of application.

During the use of this product, patients are instructed to follow the directions carefully. They should discontinue use and seek medical advice if they experience rash, itching, or excessive skin irritation. Furthermore, if the condition worsens, symptoms persist for more than 7 days, or if symptoms resolve and then recur within a few days, medical consultation is recommended.

Additional considerations include the need for pregnant or breastfeeding individuals to consult a healthcare professional before using this product. It is also crucial to keep the product out of reach of children; in the event of accidental ingestion, immediate medical assistance or contact with a Poison Control Center is necessary.

Drug Interactions

There are currently no documented drug interactions associated with this medication. Additionally, there is no information available regarding interactions with laboratory tests. As such, no specific recommendations for dosage adjustments or monitoring are warranted at this time.

Packaging & NDC

Below are the non-prescription pack sizes of Asperflex Advance (camphor, menthol, methyl salicylate). Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Asperflex Advance.
Details

Pediatric Use

Pediatric patients under 12 years of age should consult a doctor before use. For adolescents and children aged 12 years and older, the recommended application is to the affected area not more than 3 to 4 times daily.

Geriatric Use

There is no specific information available regarding the use of this medication in geriatric patients, including dosage adjustments, safety concerns, or special precautions. Healthcare providers should exercise caution when prescribing this medication to elderly patients, as individual responses may vary. It is advisable to monitor these patients closely for any adverse effects or changes in efficacy, given the lack of targeted data for this population.

Pregnancy

Pregnant patients and those who are breastfeeding should consult a healthcare professional prior to using this medication. The potential risks and benefits must be carefully considered in these populations to ensure the safety of both the mother and the fetus or infant.

Lactation

Lactating mothers are advised to consult a health professional prior to using this medication. There is currently no available data regarding the excretion of this medication in human breast milk or its effects on breastfed infants. Therefore, caution is recommended when administering this medication to lactating mothers.

Renal Impairment

Patients with renal impairment have no specific information regarding dosage adjustments, special monitoring, or safety considerations provided in the drug insert. Therefore, healthcare professionals should exercise caution when prescribing this medication to individuals with reduced kidney function, as the lack of data necessitates careful clinical judgment.

Hepatic Impairment

Patients with hepatic impairment have not been specifically studied in relation to this medication. Consequently, there are no dosage adjustments, special monitoring requirements, or precautions outlined for individuals with compromised liver function. It is recommended that healthcare providers exercise caution when prescribing this medication to patients with hepatic impairment, given the lack of data on its safety and efficacy in this population. Regular monitoring of liver function may be prudent in these cases, although specific parameters are not defined in the prescribing information.

Overdosage

In the event of an overdosage, immediate medical assistance is crucial. If the substance is ingested, healthcare professionals should advise patients or caregivers to seek medical help or contact a Poison Control Center without delay.

Prompt intervention is essential to mitigate potential adverse effects associated with overdosage. Symptoms may vary depending on the specific substance involved, and healthcare providers should be prepared to assess and manage these symptoms accordingly.

Management procedures may include supportive care and symptomatic treatment, tailored to the individual patient's needs. Continuous monitoring and evaluation are recommended to ensure patient safety and effective resolution of any complications arising from the overdosage.

Nonclinical Toxicology

No teratogenic or non-teratogenic effects have been reported in the available nonclinical studies. Additionally, there is no information regarding animal pharmacology and toxicology. The absence of data limits the assessment of potential risks associated with the compound in these areas.

Postmarketing Experience

Postmarketing experience has identified the following adverse reactions reported voluntarily or through surveillance programs: rash, itching, and excessive skin irritation. These events have been documented in the context of routine pharmacovigilance activities.

Patient Counseling

Healthcare providers should advise patients to seek immediate medical assistance or contact a Poison Control Center if the product is swallowed. It is important to instruct patients not to use the product on wounds or damaged skin, and to avoid using it in conjunction with a heating pad.

Patients should be informed that they must not use the product if they are allergic to any of its ingredients. They should be counseled to stop using the product and consult a doctor if they experience rash, itching, or excessive skin irritation. Additionally, patients should be advised to discontinue use and seek medical advice if their condition worsens, if symptoms persist for more than 7 days, or if symptoms resolve and then recur within a few days.

When using the product, patients should be reminded to follow the directions carefully and to avoid contact with the eyes, mucous membranes, or rashes. They should also be cautioned against tightly bandaging the area where the product is applied. Lastly, patients with a history of allergic reactions to aspirin or salicylates should be encouraged to consult a doctor before using the product.

Storage and Handling

The product is supplied in various package configurations, with specific NDC numbers available for identification. It is essential to store the product at room temperature, maintaining a range of 15° to 30°C (59° to 86°F). Proper storage conditions are crucial to ensure the integrity and efficacy of the product.

Additional Clinical Information

The route of administration for the medication is percutaneous, topical, and transdermal. Patients are advised to apply the treatment to the affected area no more than 3 to 4 times daily and to remove the patch from the skin after a maximum of 8 hours of application.

Clinicians should counsel patients to consult a health professional if they are pregnant or breastfeeding before use. Additionally, it is important to keep the medication out of reach of children; if ingested, medical assistance or contact with a Poison Control Center should be sought immediately.

Drug Information (PDF)

This file contains official product information for Asperflex Advance, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Data Generation & Sources

This page was automatically generated and is maintained by the AllDrugs AI Data-Science Team. It was built from the FDA Structured Product Label (DailyMed) for Asperflex Advance, retrieved by a validated AI data-extraction workflow.

All FDA-listed dosage forms and strengths are shown in the Packaging & NDC Codes section above. Regulatory status appears in the Summary Information panel above and was verified in the FDA National Drug Code directory and the NSDE NDC Directory daily file.

Note: an automated daemon monitors NSDE checksums; when the record for this NDC changes, the new file is pulled instantly and this page is refreshed.

No human clinician has reviewed this version.

Learn more in our Editorial Policy

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Primary FDA sources:

Orange Book data shown on this page are limited to Regulatory Status (Rx), Established Pharmacologic Class (EPC), and Mechanism of Action (MoA).

Regulatory data notice: Information on this page is reproduced verbatim from FDA public databases (NSDE, Orange Book, Purple Book, DailyMed SPL). NDA/ANDA drugs are FDA-approved, BLA biologics are FDA-licensed. Inclusion alone does not guarantee current market availability or imply FDA endorsement.

Medical disclaimer: This AI-generated content is provided for educational purposes only and does not constitute medical advice. Always consult a licensed healthcare professional for diagnosis or treatment decisions.