ADD CONDITION
Carboxymethylcellulose sodium/Glycerin/Polysorbate 80
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- Active ingredients
- Glycerin 10 mg/1 mL – 1 g/100 mL
- Carboxymethylcellulose Sodium 5 mg/1 mL – 0.5 g/100 mL
- Polysorbate 80 5 mg/1 mL – 0.5 g/100 mL
- Reference brand
- Refresh Optive Advanced
- Drug class
- Non-Standardized Chemical Allergen
- Dosage forms
- Liquid
- Solution/ Drops
- Route
- Ophthalmic
- Prescription status
- OTC (over the counter)
- Marketed in the U.S.
- Since 2011
- Label revision date
- March 1, 2026
- Pregnancy
- See Pregnancy Use Section
- Lactation
- See Lactation Use Section
- Active ingredients
- Glycerin 10 mg/1 mL – 1 g/100 mL
- Carboxymethylcellulose Sodium 5 mg/1 mL – 0.5 g/100 mL
- Polysorbate 80 5 mg/1 mL – 0.5 g/100 mL
- Reference brand
- Refresh Optive Advanced
- Drug class
- Non-Standardized Chemical Allergen
- Dosage forms
- Liquid
- Solution/ Drops
- Route
- Ophthalmic
- Prescription status
- OTC (over the counter)
- CSA schedule
- Not a scheduled drug
- Marketed in the U.S.
- Since 2011
- Label revision date
- March 1, 2026
- Pregnancy
- See Pregnancy Use Section
- Lactation
- See Lactation Use Section
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Drug Overview
Droptics Dry Eye Relief and Refresh eye drops are designed to provide temporary relief from discomfort caused by minor irritations, dryness, or exposure to wind and sun. These lubricant eye drops act as protectants against further irritation, helping to soothe your eyes.
The Refresh line includes various formulations, such as Refresh Optive Mega-3, which is enhanced with flaxseed oil, and Refresh Digital, which features HydroCell technology for fast-acting relief. All these products are preservative-free and come in convenient drop forms, making them easy to use for anyone experiencing dry or irritated eyes.
Uses
You can use these eye drops for the temporary relief of burning, irritation, and discomfort caused by dryness of the eye or exposure to wind and sun. They also serve as a protectant against further irritation, helping to keep your eyes comfortable throughout the day.
Dosage and Administration
You can use the eye drop solutions by instilling 1 or 2 drops into the affected eye(s) as needed. After using the drops, make sure to tightly screw on the cap to seal the bottle. If you are using a container that needs to be discarded after use, be sure to do so properly.
Before using any of these products for the first time, it's a good idea to read the “Instructions for Use” included in the packaging to ensure you understand how to use them correctly.
What to Avoid
You should avoid using these eye drops if you experience eye pain, changes in vision, continued redness or irritation of the eye, or if your condition worsens or persists for more than 72 hours. If any of these symptoms occur, it is important to stop use and consult a doctor. There are no listed contraindications, controlled substance classifications, or concerns regarding abuse, misuse, or dependence (a state where one relies on a substance).
Side Effects
When using eye drop solutions like Droptics Dry Eye Relief or Refresh products, it's important to be aware of potential side effects. You should stop using the product and consult a doctor if you experience eye pain, changes in vision, or if redness or irritation persists for more than 72 hours.
These products are for external use only, and you should avoid touching the tip of the container to any surface to prevent contamination. If the solution changes color, do not use it. Keep these products out of reach of children, and if swallowed, seek medical help or contact a Poison Control Center immediately.
Warnings and Precautions
This product is for external use only. Avoid touching the tip of the container to any surface to prevent contamination, and always replace the cap after use. If the solution changes color, do not use it.
Stop using the product and consult a doctor if you experience any of the following:
Eye pain
Changes in vision
Continued redness or irritation of the eye
If your condition worsens or lasts more than 72 hours
Keep this product out of reach of children. If swallowed, seek medical help or contact a Poison Control Center immediately.
Overdose
If you accidentally swallow any eye drop solutions, such as Droptics Dry Eye Relief or any of the Refresh products (Optive Mega-3, Optive Advanced, Digital, etc.), it’s important to seek medical help immediately. You should contact a Poison Control Center or go to the nearest emergency room right away.
Signs of an overdose may not be obvious, but if you experience unusual symptoms after swallowing these products, do not hesitate to seek assistance. Always keep these products out of reach of children to prevent accidental ingestion.
Pregnancy Use
The safety of using eye drops like Droptics Dry Eye Relief, Refresh Optive Mega-3 Pf, Refresh Optive Advanced, and Refresh Digital during pregnancy has not been established. There are no specific contraindications or dosage modifications mentioned for pregnant individuals, but caution is advised since the effects on pregnancy are not well studied.
It's important to consult your healthcare provider before using these products if you are pregnant or planning to become pregnant, as there is no information available regarding potential risks to the fetus. Always prioritize your health and the health of your baby by seeking professional advice.
Lactation Use
You can use the following eye drop products while breastfeeding without specific concerns. For Droptics Dry Eye Relief, Refresh Optive Mega-3 PF, Refresh Optive Advanced, and Refresh Digital, there are no warnings or recommendations against their use for nursing mothers. Additionally, there is no information indicating that these products are excreted in breast milk (meaning they do not pass into breast milk) or that they pose any risk to your infant. Always consult with your healthcare provider if you have any questions or concerns about using these products while breastfeeding.
Pediatric Use
It’s important to keep all eye drop solutions, such as Droptics Dry Eye Relief and various Refresh products (like Refresh Optive Mega-3 Pf, Refresh Optive Advanced, and Refresh Digital), out of reach of children. If a child accidentally swallows any of these products, you should seek medical help or contact a Poison Control Center immediately. Always prioritize safety and ensure these medications are stored securely.
Geriatric Use
When considering eye drops like Droptics Dry Eye Relief, Refresh Optive Mega-3 Pf, Refresh Optive Advanced, and Refresh Digital, it's important to note that there is no specific information regarding their use in older adults. This means that the manufacturers have not provided details on dosage adjustments, safety concerns, or special precautions for elderly patients.
As always, if you are an older adult or a caregiver, it's wise to consult with a healthcare professional before using any new medication, especially if you have underlying health conditions or are taking other medications. This ensures that you receive personalized advice tailored to your health needs.
Renal Impairment
When using eye drop products like Droptics Dry Eye Relief, Refresh Optive Mega-3, and others in the Refresh line, you can feel reassured that there are no specific dosage adjustments or monitoring requirements related to kidney problems mentioned in their labels. This means that, as of the current information available, these products do not pose additional risks or require special considerations for individuals with renal impairment. However, it's always a good practice to consult with your healthcare provider if you have any concerns about your kidney health and the use of any medication.
Hepatic Impairment
You can use the following eye drop products without specific concerns regarding liver health, as there are no dosage adjustments or special monitoring required for individuals with liver problems. The products include:
Droptics Dry Eye Relief (Liquid)
Refresh Optive Mega-3 Pf (Solution/Drops)
Refresh Digital Pf (Solution/Drops)
Refresh Optive Advanced (Solution/Drops)
Refresh Digital (Solution/Drops)
Refresh Optive Mega-3 (Solution/Drops)
These products do not provide specific information about hepatic (liver) impairment, so you can feel confident using them as directed.
Drug Interactions
You can use products like Droptics Dry Eye Relief, Refresh Optive Mega-3 Pf, Refresh Optive Advanced, and Refresh Digital without worrying about drug interactions, as there is no information indicating any interactions with other medications or laboratory tests. However, it's always a good idea to discuss any medications or treatments you are using with your healthcare provider. This ensures that you receive personalized advice and helps prevent any potential issues with your overall health and treatment plan.
Storage and Handling
To ensure the best quality and safety of your eye drop products, store them at a temperature between 15°C and 25°C (59°F and 77°F). After each use, make sure to tightly screw the cap back on to seal the container. Always check that the tape seals on the top and bottom flaps are intact before using, and only use the product before the expiration date marked on the container.
Once opened, remember to discard the drops 90 days later to maintain safety. If you have single-use containers, ensure they are intact before use. For products in vials, keep them in their pouch until you're ready to use them. Always retain the carton for future reference.
FAQ
What is Droptics Dry Eye Relief used for?
Droptics Dry Eye Relief is indicated for the temporary relief of discomfort due to minor irritations of the eye or exposure to wind or sun, acting as a protectant against further irritation.
How should I use Refresh OPTIVE MEGA-3®?
Instill 1 or 2 drops in the affected eye(s) as needed and discard the container after use.
What is Refresh® DIGITAL PF?
Refresh® DIGITAL PF is a lubricant eye drop designed to provide temporary relief from eye dryness, burning, irritation, and discomfort.
Are there any contraindications for using Refresh OPTIVE® ADVANCED?
No contraindications are listed for Refresh OPTIVE® ADVANCED Lubricant Eye Drops.
What should I do if I experience eye pain or changes in vision?
Stop using the drops and ask a doctor if you experience eye pain, changes in vision, continued redness or irritation, or if the condition worsens or persists for more than 72 hours.
Is Refresh OPTIVE MEGA-3® safe to use during pregnancy?
The safety of Refresh OPTIVE MEGA-3® during pregnancy has not been established, and it should only be used if the potential benefit justifies the potential risk to the fetus.
How should I store Refresh® Digital Lubricant Eye Drops?
Store the drops at 59°-77°F (15°-25°C) and discard them 90 days after opening.
What should I do if the solution changes color?
If the solution changes color, do not use it.
Can nursing mothers use Refresh OPTIVE MEGA-3®?
Nursing mothers should consult a healthcare professional before using this product, as there is a potential for excretion in breast milk.
What should I do if I accidentally swallow Refresh OPTIVE® ADVANCED?
If swallowed, get medical help or contact a Poison Control Center right away.
What is the recommended storage condition for Refresh OPTIVE® ADVANCED?
Store at 59°-77°F (15°-25°C) and discard 90 days after opening.
Uses and Indications
This drug is indicated for the temporary relief of burning, irritation, and discomfort due to dryness of the eye or exposure to wind or sun. It may also be used as a protectant against further irritation.
Limitations of Use
No teratogenic or nonteratogenic effects have been mentioned for this drug.
Dosage and Administration
Instill 1 or 2 drops in the affected eye(s) as needed. Prior to the first use of any solution, it is recommended to read the “Instructions for Use” provided within the carton. After each use, ensure that the cap is tightly screwed on to seal the container. For solutions that require discarding the container after use, please adhere to this guideline to maintain safety and efficacy.
Contraindications
There are no contraindications listed for the products reviewed. However, it is advised that individuals should discontinue use and consult a healthcare professional if they experience eye pain, changes in vision, continued redness or irritation of the eye, or if the condition worsens or persists for more than 72 hours.
Warnings and Precautions
For external use only. To avoid contamination, do not touch the tip of the container to any surface. Replace the cap after each use. If the solution changes color, do not use.
Serious Warnings
Stop use and ask a doctor if:
Eye pain occurs.
Changes in vision occur.
Redness or irritation of the eye persists.
The condition worsens or lasts more than 72 hours.
Emergency Medical Help
If swallowed, get medical help or contact a Poison Control Center right away.
General Precautions
Keep out of reach of children.
Do not reuse containers once opened; discard after use.
Do not touch the unit-dose tip to the eye.
Side Effects
Patients using eye drop solutions may experience various adverse reactions. The following information summarizes the potential side effects and warnings associated with these products.
Serious Reactions
Patients should stop using the product and consult a doctor if they experience any of the following:
Eye pain
Changes in vision
Continued redness or irritation of the eye
Worsening of the condition or if symptoms persist for more than 72 hours
General Warnings
These products are for external use only.
To avoid contamination, patients should not touch the tip of the container to any surface and should replace the cap after each use.
If the solution changes color, it should not be used.
Safety Precautions
Keep out of reach of children. If swallowed, patients should seek medical help or contact a Poison Control Center immediately.
Additional Notes
Some formulations may have specific instructions regarding the disposal of the container after use, emphasizing that once opened, the product should not be reused.
This information is crucial for ensuring the safe use of eye drop solutions and minimizing the risk of adverse reactions.
Drug Interactions
No drug interactions information is available for Droptics Dry Eye Relief, Refresh Optive Mega-3 Pf, Refresh Optive Advanced, and Refresh Digital. Additionally, there are no reported interactions with laboratory tests for these products. All formulations are classified as solutions or drops, and no specific pharmacokinetic or pharmacodynamic interactions have been documented.
Pediatric Use
Pediatric patients should be monitored closely when using eye drop solutions, as all formulations listed are intended to be kept out of reach of children. In the event of accidental ingestion, immediate medical assistance should be sought, or contact with a Poison Control Center is advised.
The following products are included in this summary:
Droptics Dry Eye Relief (Liquid)
Refresh Optive Mega-3 Pf (Solution/Drops)
Refresh Optive Advanced (Solution/Drops)
Refresh Digital (Solution/Drops)
All formulations emphasize the importance of keeping them away from children and the necessity for prompt medical intervention if swallowed.
Geriatric Use
No specific information regarding geriatric use, dosage adjustments, safety concerns, or special precautions for elderly patients is provided in the inserts for Droptics Dry Eye Relief, Refresh Optive Mega-3 Pf, Refresh Optive Advanced, and Refresh Digital. Healthcare professionals should consider the lack of data when prescribing these products to geriatric patients and monitor for any potential adverse effects.
Pregnancy
The safety of Droptics Dry Eye Relief, Refresh Optive Mega-3 Pf, Refresh Optive Advanced, and Refresh Digital during pregnancy has not been established. There are no specific contraindications mentioned for the use of these products in pregnant patients. However, caution is advised with Refresh Optive Mega-3 Pf, as the effects on pregnancy are not well studied.
No information is provided regarding potential risks to the fetus for any of these products. Additionally, there are no specified dosage modifications for pregnant individuals across these formulations.
It is recommended that pregnant patients consult a healthcare provider before using these products, especially if they are planning to become pregnant or have any concerns regarding their use during pregnancy.
Lactation
There are no specific warnings or precautions regarding the use of Droptics Dry Eye Relief, Refresh Optive Mega-3 Pf, Refresh Optive Advanced, or Refresh Digital in nursing mothers. Additionally, the available data does not provide information on the potential for excretion of these products in breast milk or any associated risks to breastfed infants. Therefore, healthcare professionals may consider these products for use by lactating mothers, but the absence of specific lactation-related data should be noted.
Renal Impairment
Patients with renal impairment have not been specifically addressed in the available labeling for the following products: Droptics Dry Eye Relief, Refresh Optive Mega-3 Pf, Refresh Digital Pf, Refresh Optive Advanced, Refresh Digital, and Refresh Optive Mega-3.
No dosage adjustments, special monitoring, or safety considerations for individuals with reduced kidney function are provided in the inserts for these products. Therefore, healthcare professionals should exercise caution and consider individual patient circumstances when prescribing these medications to patients with renal impairment, as the lack of specific guidance necessitates careful clinical judgment.
Hepatic Impairment
Patients with hepatic impairment have not been specifically studied in relation to the use of the following products: Droptics Dry Eye Relief, Refresh Optive Mega-3 Pf, Refresh Digital Pf, Refresh Optive Advanced, Refresh Digital, and Refresh Optive Mega-3. Consequently, there is no available information regarding dosage adjustments, special monitoring, or precautions for this patient population. It is recommended that healthcare providers exercise caution and consider individual patient factors when prescribing these products to patients with liver problems, as specific guidelines or recommendations are not provided in the product inserts.
Overdosage
In the event of an overdose, immediate medical assistance should be sought. If any of the products, including Droptics Dry Eye Relief, Refresh Optive Mega-3 Pf, Refresh Digital Pf, Refresh Optive Advanced, Refresh Digital, or Refresh Optive Mega-3, are swallowed, it is crucial to contact a Poison Control Center or seek medical help without delay.
Symptoms of overdose may vary, but due to the nature of these products, monitoring for any adverse reactions is recommended. Healthcare professionals should be prepared to provide supportive care as needed. Prompt intervention is essential to ensure patient safety and mitigate potential complications associated with the ingestion of these eye care solutions.
Nonclinical Toxicology
Teratogenicity
No information regarding teratogenic effects is available for any of the products reviewed.
Carcinogenesis, Mutagenesis, Impairment of Fertility
There is no information provided concerning carcinogenicity, mutagenicity, or impairment of fertility for the products assessed.
Animal Toxicology
No data on animal pharmacology and toxicology has been provided for the products included in this review.
Storage and Handling
Droptics Dry Eye Relief is supplied as a liquid formulation. It should be stored at a temperature range of 20 - 25°C (68 - 77°F). After each use, the cap must be tightly screwed on to ensure proper sealing.
Refresh Optive Mega-3 Pf, Refresh Digital Pf, Refresh Optive Advanced, Refresh Digital, and Refresh Optive Mega-3 are all supplied as solutions or drops. These products must be used only if the tape seals on the top and bottom flaps are intact. Each product should be used before the expiration date marked on the container and discarded 90 days after opening. The recommended storage temperature for these solutions is between 59°-77°F (15°-25°C). Additionally, Refresh Optive Mega-3 vials should be stored in the pouch until use, and it is advised to retain the carton for future reference for Refresh Digital Pf, Refresh Optive Advanced, and Refresh Digital.
Product Labels
The table below lists all over-the-counter labels containing carboxymethylcellulose sodium, glycerin, and polysorbate 80. Use it to compare dosage forms, strengths, and uses across products.
More Details | |||||
|---|---|---|---|---|---|
Droptics LLC | Liquid | Ophthalmic |
| 2025 | |
Indications
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Allergan, Inc. | Solution/ Drops | Ophthalmic |
| 2020 | |
Indications
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Allergan, Inc. | Solution/ Drops | Ophthalmic |
| 2020 | |
Indications
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Allergan, Inc. | Solution/ Drops | Ophthalmic |
| 2011 | |
Indications
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Allergan, Inc. | Solution/ Drops | Ophthalmic |
| 2013 | |
Indications
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Allergan, Inc. | Solution/ Drops | Ophthalmic |
| 2017 | |
Indications
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Allergan, Inc. | Solution/ Drops | Ophthalmic |
| 2026 | |
Indications
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