Refresh Optive Advanced

Last content change Sep 1, 2022checked dailysee data sync status

Active ingredients: Glycerin 10 mg/1 mL
Carboxymethylcellulose Sodium 5 mg/1 mL
Polysorbate 80 5 mg/1 mL
Other brand names: Droptics Dry Eye Relief (by Droptics Llc)
Refresh Digital (by Allergan, Inc.)
Refresh Digital Pf (by Allergan, Inc.)
Refresh Optive Advanced (by Allergan, Inc.)
Refresh Optive Mega-3 (by Allergan, Inc.)
View full label-group details →
Drug class: Non-Standardized Chemical Allergen
Dosage form: Solution/ Drops
Route: Ophthalmic
Prescription status: OTC (over the counter)
Pregnancy: See Pregnancy Use Section
Lactation: See Lactation Use Section
Marketed in the U.S.: Since 2011
Label revision date: September 1, 2022
Drug Information (PDF): Prescribing information, PDF file

Active ingredients: Glycerin 10 mg/1 mL
Carboxymethylcellulose Sodium 5 mg/1 mL
Polysorbate 80 5 mg/1 mL
Other brand names: Droptics Dry Eye Relief (by Droptics Llc)
Refresh Digital (by Allergan, Inc.)
Refresh Digital Pf (by Allergan, Inc.)
Refresh Optive Advanced (by Allergan, Inc.)
Refresh Optive Mega-3 (by Allergan, Inc.)
View full label-group details →
Drug class: Non-Standardized Chemical Allergen
Dosage form: Solution/ Drops
Route: Ophthalmic
Prescription status: OTC (over the counter)
CSA schedule: Not a scheduled drug
Pregnancy: See Pregnancy Use Section
Lactation: See Lactation Use Section
Marketed in the U.S.: Since 2011
Label revision date: September 1, 2022
Manufacturer: Allergan, Inc.
Registration number: M018
NDC root: 0023-4307
Drug Information (PDF): Prescribing information, PDF file

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Drug Overview

Refresh OPTIVE® ADVANCED Lubricant Eye Drops are designed to provide temporary relief for dry eyes, helping to alleviate symptoms such as burning, irritation, and discomfort caused by dryness or environmental factors like wind and sun. These eye drops contain Hydrocell®, which works to protect your eyes from further irritation while offering triple-action relief.

Available in a convenient 0.33 fl oz (10 mL) sterile bottle, these drops are a helpful option for anyone experiencing dryness in their eyes, ensuring comfort and protection throughout the day.

Uses

If you're experiencing burning, irritation, or discomfort in your eyes due to dryness or exposure to wind or sun, this product can provide temporary relief. It helps soothe your eyes and alleviate those uncomfortable sensations.

Additionally, it can act as a protectant, helping to shield your eyes from further irritation. This means you can feel more comfortable and less bothered by environmental factors that may affect your eyes.

Dosage and Administration

When you need to use this medication for your eyes, simply instill (put) 1 or 2 drops into the affected eye or eyes. You can do this as needed, depending on your symptoms. Make sure to follow any specific instructions provided by your healthcare provider to ensure the best results.

What to Avoid

It's important to be aware of certain situations where you should not use this medication. Specifically, you should avoid using it if you experience eye pain, changes in vision, or ongoing redness or irritation of the eye. Additionally, if your condition worsens or does not improve within 72 hours, you should refrain from using the medication.

Currently, there are no specific contraindications, controlled substance classifications, or noted risks of abuse, misuse, or dependence associated with this medication. However, always prioritize your health and consult a healthcare professional if you have any concerns or questions.

Side Effects

You should be aware that this product is for external use only. To prevent contamination, avoid touching the tip of the container to any surface and always replace the cap after use. If you notice any changes in the color of the solution, do not use it.

If you experience eye pain, changes in vision, ongoing redness or irritation of the eye, or if your condition worsens or does not improve within 72 hours, stop using the product and consult a doctor. Additionally, if the product is swallowed, seek medical help or contact a Poison Control Center immediately.

Warnings and Precautions

This product is for external use only, so please avoid applying it to any internal areas. To keep the solution clean, do not touch the tip of the container to any surface, and always replace the cap after use. If you notice any change in the color of the solution, do not use it.

You should stop using this product and contact your doctor if you experience eye pain, changes in your vision, ongoing redness or irritation of the eye, or if your condition worsens or does not improve after 72 hours. Additionally, keep this product out of reach of children. If it is swallowed, seek medical help or contact a Poison Control Center immediately.

Overdose

If you or someone else has swallowed too much of this medication, it’s important to seek medical help immediately. You can do this by contacting a Poison Control Center or going to the nearest emergency room.

Signs of an overdose can vary, but they may include unusual symptoms that are not typical for you. If you notice anything concerning, don’t hesitate to get help. Remember, acting quickly can make a significant difference in ensuring safety and health.

Pregnancy Use

There is currently no specific information available regarding the use of Refresh Optive Advanced during pregnancy. This means that safety concerns, dosage adjustments, or any special precautions for pregnant individuals have not been addressed in the drug insert.

If you are pregnant or planning to become pregnant, it is important to consult with your healthcare provider before using this product to ensure it is safe for you and your baby. Always prioritize open communication with your doctor about any medications or treatments you are considering during this time.

Lactation Use

When it comes to breastfeeding, it's important to be aware that there are no specific guidelines or statements regarding nursing mothers or lactation (the process of producing milk). This means that the information available does not provide clear insights into how this medication may affect you or your baby while breastfeeding.

If you have concerns about breastfeeding while taking this medication, it's best to consult with your healthcare provider for personalized advice and to ensure the safety and well-being of both you and your infant.

Pediatric Use

It's important to keep this medication out of reach of children to prevent accidental ingestion. If your child swallows any of it, seek medical help immediately or contact a Poison Control Center for guidance. Taking these precautions can help ensure your child's safety.

Geriatric Use

When considering the use of Refresh Optive Advanced, it's important to note that there is no specific information available regarding its use in older adults. This means that there are no recommended dosage adjustments, safety concerns, or special precautions outlined for elderly patients.

If you are an older adult or a caregiver, it's always a good idea to consult with a healthcare professional before starting any new medication. They can provide personalized advice based on individual health needs and conditions.

Renal Impairment

If you have kidney problems, it's important to know that the information provided does not include specific guidelines for dosage adjustments, special monitoring, or safety considerations related to renal impairment (kidney issues). This means that there are no tailored recommendations for how your treatment may need to change based on your kidney function.

Always consult your healthcare provider for personalized advice and to ensure that your treatment is safe and effective, especially if you have any concerns about your kidney health.

Hepatic Impairment

If you have liver problems, it's important to know that the information provided does not include specific guidelines for dosage adjustments, special monitoring, or precautions related to your condition. This means that there are no tailored recommendations for how the medication may affect you differently due to your liver health.

Always consult your healthcare provider for personalized advice and to ensure that any treatment plan is safe and effective for your specific situation. They can help determine the best approach based on your liver function and overall health.

Drug Interactions

It's important to have open conversations with your healthcare provider about any medications or tests you may be taking. While there are no specific drug interactions or laboratory test interactions noted for this medication, your healthcare provider can help ensure that everything you are taking works well together and is safe for you. Always share your complete list of medications and any recent lab tests to avoid any potential issues. Your health and safety should always come first.

Storage and Handling

To ensure the best use of your product, make sure the tape seals on the top and bottom flaps are intact before using it. Always check the expiration date marked on the container and remember to discard the product 90 days after opening.

For proper storage, keep the product in a cool, dry place at a temperature between 59°F and 77°F (15°C to 25°C). It's also important to retain the carton for future reference, as it may contain useful information. Following these guidelines will help you use the product safely and effectively.

Additional Information

No further information is available.

FAQ

What is Refresh OPTIVE® ADVANCED Lubricant Eye Drops used for?

It is used for the temporary relief of burning, irritation, and discomfort due to dryness of the eye or exposure to wind or sun.

How should I use Refresh OPTIVE® ADVANCED Lubricant Eye Drops?

Instill 1 or 2 drops in the affected eye(s) as needed.

Are there any contraindications for using this eye drop?

No contraindications are listed for Refresh OPTIVE® ADVANCED.

What should I do if I experience eye pain or changes in vision?

Stop use and ask a doctor if you experience eye pain, changes in vision, continued redness or irritation of the eye, or if the condition worsens or persists for more than 72 hours.

What precautions should I take when using this product?

For external use only. Avoid touching the tip of the container to any surface to prevent contamination, and replace the cap after use.

What should I do if I swallow Refresh OPTIVE® ADVANCED?

Get medical help or contact a Poison Control Center right away if swallowed.

How should I store Refresh OPTIVE® ADVANCED Lubricant Eye Drops?

Store at 59°-77°F (15°-25°C) and discard 90 days after opening.

Is there any specific information regarding use during pregnancy or nursing?

No specific information regarding use during pregnancy or nursing mothers is provided in the drug insert.

What is the shelf life of Refresh OPTIVE® ADVANCED?

Use before the expiration date marked on the container and discard 90 days after opening.

Packaging Info

Below are the non-prescription pack sizes of Refresh Optive Advanced (carboxymethylcellulose sodium, glycerin, and polysorbate 80). Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Refresh Optive Advanced.

	1 in carton 2 mL in bottle 1 item total	Solution/ Drops	Carboxymethylcellulose Sodium 5 mg/1 mL Glycerin 10 mg/1 mL Polysorbate 80 5 mg/1 mL
Product details Regulatory status — Marketed All current FDA data sets list this NDC as actively marketed. FDA record dates for this NDC: NSDE file: March 4, 2026 → status: Active (as of November 30, 2011) Type Type 0: Not a Combination Product Active ingredients Carboxymethylcellulose Sodium 5 mg/1 mL Glycerin 10 mg/1 mL Polysorbate 80 5 mg/1 mL Inactive ingredients boric acid carbomer copolymer type a castor oil erythritol levocarnitine water sodium chlorite sodium hydroxide
	1 in carton 3 mL in bottle, dropper 1 item total	Solution/ Drops	Carboxymethylcellulose Sodium 5 mg/1 mL Glycerin 10 mg/1 mL Polysorbate 80 5 mg/1 mL
Product details Regulatory status — Discontinued NSDE (NDC Directory) reports this NDC as Not Marketed. FDA record dates for this NDC: NSDE file: March 4, 2026 → status: Marketing ended (as of February 24, 2019) Type Type 0: Not a Combination Product Active ingredients Carboxymethylcellulose Sodium 5 mg/1 mL Glycerin 10 mg/1 mL Polysorbate 80 5 mg/1 mL Inactive ingredients boric acid carbomer copolymer type a castor oil erythritol levocarnitine water sodium chlorite sodium hydroxide
	1 in carton 10 mL in bottle, dropper 1 item total	Solution/ Drops	Carboxymethylcellulose Sodium 5 mg/1 mL Glycerin 10 mg/1 mL Polysorbate 80 5 mg/1 mL
Product details Regulatory status — Marketed All current FDA data sets list this NDC as actively marketed. FDA record dates for this NDC: NSDE file: March 4, 2026 → status: Active (as of November 30, 2011) Type Type 0: Not a Combination Product Active ingredients Carboxymethylcellulose Sodium 5 mg/1 mL Glycerin 10 mg/1 mL Polysorbate 80 5 mg/1 mL Inactive ingredients boric acid carbomer copolymer type a castor oil erythritol levocarnitine water sodium chlorite sodium hydroxide
	1 in carton 15 mL in bottle 1 item total	Solution/ Drops	Carboxymethylcellulose Sodium 5 mg/1 mL Glycerin 10 mg/1 mL Polysorbate 80 5 mg/1 mL
Product details Regulatory status — Discontinued NSDE (NDC Directory) reports this NDC as Not Marketed. FDA record dates for this NDC: NSDE file: March 4, 2026 → status: Marketing ended (as of December 10, 2016) Type Type 0: Not a Combination Product Active ingredients Carboxymethylcellulose Sodium 5 mg/1 mL Glycerin 10 mg/1 mL Polysorbate 80 5 mg/1 mL Inactive ingredients boric acid carbomer copolymer type a castor oil erythritol levocarnitine water sodium chlorite sodium hydroxide
	2 in carton 10 mL in bottle, dropper 2 items total	Solution/ Drops	Carboxymethylcellulose Sodium 5 mg/1 mL Glycerin 10 mg/1 mL Polysorbate 80 5 mg/1 mL
Product details Regulatory status — Marketed All current FDA data sets list this NDC as actively marketed. FDA record dates for this NDC: NSDE file: March 4, 2026 → status: Active (as of November 30, 2011) Type Type 0: Not a Combination Product Active ingredients Carboxymethylcellulose Sodium 5 mg/1 mL Glycerin 10 mg/1 mL Polysorbate 80 5 mg/1 mL Inactive ingredients boric acid carbomer copolymer type a castor oil erythritol levocarnitine water sodium chlorite sodium hydroxide

Drug Information (PDF)

This file contains official product information for Refresh Optive Advanced, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Description

No description information is available for the specified drug.

Uses and Indications

This drug is indicated for the temporary relief of burning, irritation, and discomfort associated with dryness of the eye or exposure to wind or sun. It may also be used as a protectant against further irritation.

Dosage and Administration

Healthcare professionals are advised to instill 1 or 2 drops of the medication in the affected eye(s) as needed. The frequency of administration should be determined based on the clinical condition of the patient and the response to treatment. It is important to ensure that the drops are administered in a sterile manner to prevent contamination.

Contraindications

Use is contraindicated in patients experiencing eye pain, changes in vision, continued redness or irritation of the eye, or if the condition worsens or persists for more than 72 hours. These conditions may indicate a more serious underlying issue that requires medical evaluation.

Warnings and Precautions

For external use only. To prevent contamination, it is imperative that the tip of the container not be touched to any surface. The cap should be securely replaced after each use. If the solution exhibits any change in color, it must not be used.

Healthcare professionals should advise patients to discontinue use and seek medical attention if they experience any of the following symptoms: eye pain, changes in vision, persistent redness or irritation of the eye, or if the condition worsens or does not improve within 72 hours.

It is essential to keep this product out of the reach of children. In the event of accidental ingestion, immediate medical assistance should be sought, or contact with a Poison Control Center should be made without delay.

Side Effects

Patients using this product should be aware of several important warnings and potential adverse reactions. The product is intended for external use only. To prevent contamination, patients are advised not to touch the tip of the container to any surface and to replace the cap after each use.

In the event that the solution changes color, it should not be used. Patients are instructed to stop using the product and consult a doctor if they experience any of the following: eye pain, changes in vision, continued redness or irritation of the eye, or if the condition worsens or persists for more than 72 hours.

Additionally, if the product is swallowed, patients should seek medical help or contact a Poison Control Center immediately.

Drug Interactions

There are currently no documented drug interactions associated with this medication. Additionally, there is no information available regarding interactions with laboratory tests. As such, no specific recommendations for dosage adjustments or monitoring are warranted at this time.

Packaging & NDC

Packaging configurations for Refresh Optive Advanced.

	1 in carton 2 mL in bottle 1 item total	Solution/ Drops	Carboxymethylcellulose Sodium 5 mg/1 mL Glycerin 10 mg/1 mL Polysorbate 80 5 mg/1 mL
Product details Regulatory status — Marketed All current FDA data sets list this NDC as actively marketed. FDA record dates for this NDC: NSDE file: March 4, 2026 → status: Active (as of November 30, 2011) Type Type 0: Not a Combination Product Active ingredients Carboxymethylcellulose Sodium 5 mg/1 mL Glycerin 10 mg/1 mL Polysorbate 80 5 mg/1 mL Inactive ingredients boric acid carbomer copolymer type a castor oil erythritol levocarnitine water sodium chlorite sodium hydroxide
	1 in carton 3 mL in bottle, dropper 1 item total	Solution/ Drops	Carboxymethylcellulose Sodium 5 mg/1 mL Glycerin 10 mg/1 mL Polysorbate 80 5 mg/1 mL
Product details Regulatory status — Discontinued NSDE (NDC Directory) reports this NDC as Not Marketed. FDA record dates for this NDC: NSDE file: March 4, 2026 → status: Marketing ended (as of February 24, 2019) Type Type 0: Not a Combination Product Active ingredients Carboxymethylcellulose Sodium 5 mg/1 mL Glycerin 10 mg/1 mL Polysorbate 80 5 mg/1 mL Inactive ingredients boric acid carbomer copolymer type a castor oil erythritol levocarnitine water sodium chlorite sodium hydroxide
	1 in carton 10 mL in bottle, dropper 1 item total	Solution/ Drops	Carboxymethylcellulose Sodium 5 mg/1 mL Glycerin 10 mg/1 mL Polysorbate 80 5 mg/1 mL
Product details Regulatory status — Marketed All current FDA data sets list this NDC as actively marketed. FDA record dates for this NDC: NSDE file: March 4, 2026 → status: Active (as of November 30, 2011) Type Type 0: Not a Combination Product Active ingredients Carboxymethylcellulose Sodium 5 mg/1 mL Glycerin 10 mg/1 mL Polysorbate 80 5 mg/1 mL Inactive ingredients boric acid carbomer copolymer type a castor oil erythritol levocarnitine water sodium chlorite sodium hydroxide
	1 in carton 15 mL in bottle 1 item total	Solution/ Drops	Carboxymethylcellulose Sodium 5 mg/1 mL Glycerin 10 mg/1 mL Polysorbate 80 5 mg/1 mL
Product details Regulatory status — Discontinued NSDE (NDC Directory) reports this NDC as Not Marketed. FDA record dates for this NDC: NSDE file: March 4, 2026 → status: Marketing ended (as of December 10, 2016) Type Type 0: Not a Combination Product Active ingredients Carboxymethylcellulose Sodium 5 mg/1 mL Glycerin 10 mg/1 mL Polysorbate 80 5 mg/1 mL Inactive ingredients boric acid carbomer copolymer type a castor oil erythritol levocarnitine water sodium chlorite sodium hydroxide
	2 in carton 10 mL in bottle, dropper 2 items total	Solution/ Drops	Carboxymethylcellulose Sodium 5 mg/1 mL Glycerin 10 mg/1 mL Polysorbate 80 5 mg/1 mL
Product details Regulatory status — Marketed All current FDA data sets list this NDC as actively marketed. FDA record dates for this NDC: NSDE file: March 4, 2026 → status: Active (as of November 30, 2011) Type Type 0: Not a Combination Product Active ingredients Carboxymethylcellulose Sodium 5 mg/1 mL Glycerin 10 mg/1 mL Polysorbate 80 5 mg/1 mL Inactive ingredients boric acid carbomer copolymer type a castor oil erythritol levocarnitine water sodium chlorite sodium hydroxide

Pediatric Use

Pediatric patients should be advised to keep this medication out of reach of children. In the event of accidental ingestion, immediate medical assistance should be sought, or contact with a Poison Control Center is recommended.

Geriatric Use

There is no specific information regarding the use of Refresh Optive Advanced in geriatric patients, including dosage adjustments, safety concerns, or special precautions. Healthcare providers should exercise caution when prescribing this medication to elderly patients, as individual responses may vary. Monitoring for any adverse effects or changes in efficacy is advisable in this population, given the lack of targeted data.

Pregnancy

There is no specific information regarding the use of Refresh Optive Advanced during pregnancy, including safety concerns, dosage modifications, or special precautions. Healthcare professionals should consider the lack of data when prescribing this product to pregnant patients. It is advisable to weigh the potential benefits against any unknown risks to fetal outcomes. Women of childbearing potential should be counseled accordingly.

Lactation

There are no specific statements regarding the use of this medication in nursing mothers or its effects during lactation. Additionally, there is no available data on the excretion of this medication in breast milk or its potential effects on breastfed infants. Healthcare professionals should consider the absence of information when advising lactating mothers about the use of this medication.

Renal Impairment

Patients with renal impairment have not been specifically addressed in the available prescribing information. There are no dosage adjustments, special monitoring requirements, or safety considerations outlined for individuals with reduced kidney function. Healthcare professionals should exercise caution and consider the lack of data when prescribing to this patient population.

Hepatic Impairment

Patients with hepatic impairment have not been specifically studied in clinical trials for this medication. Consequently, there is no available information regarding dosage adjustments, special monitoring requirements, or precautions for individuals with compromised liver function. It is recommended that healthcare providers exercise caution when prescribing this medication to patients with hepatic impairment, given the lack of data on its safety and efficacy in this population. Regular monitoring of liver function may be warranted in these patients to ensure their safety while on treatment.

Overdosage

In the event of an overdosage, immediate medical intervention is crucial. If the substance is ingested, healthcare professionals are advised to seek medical assistance or contact a Poison Control Center without delay.

Prompt action is essential to mitigate potential adverse effects associated with overdosage. Symptoms may vary depending on the specific substance involved; therefore, a thorough assessment by medical personnel is recommended to determine the appropriate course of action.

Management procedures may include supportive care and symptomatic treatment, tailored to the individual patient's needs. Continuous monitoring and evaluation are critical to ensure patient safety and effective management of any complications that may arise from the overdosage.

Nonclinical Toxicology

No teratogenic or non-teratogenic effects have been reported in the available nonclinical studies. Additionally, there is no information regarding animal pharmacology and toxicology. The absence of data limits the assessment of potential risks associated with the compound in these areas.

Postmarketing Experience

No postmarketing experience details are available in the insert text.

Patient Counseling

Healthcare providers should advise patients to keep the medication out of reach of children to prevent accidental ingestion. Instruct patients that if the medication is swallowed, they should seek medical help or contact a Poison Control Center immediately.

Additionally, healthcare providers should inform patients to discontinue use and consult a doctor if they experience any of the following symptoms: eye pain, changes in vision, persistent redness or irritation of the eye, or if their condition worsens or does not improve after 72 hours. This guidance is essential to ensure patient safety and effective management of their condition.

Storage and Handling

The product is supplied in a secure carton, which should be retained for future reference. It is essential to ensure that the tape seals on the top and bottom flaps are intact before use. The product must be utilized before the expiration date indicated on the container. Once opened, the product should be discarded 90 days after opening to ensure safety and efficacy.

Storage conditions require the product to be kept at a temperature range of 59°-77°F (15°-25°C). Proper handling and adherence to these storage guidelines are crucial for maintaining the integrity of the product.

Additional Clinical Information

No further data are available.

Drug Information (PDF)

This file contains official product information for Refresh Optive Advanced, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Data Generation & Sources

This page was automatically generated and is maintained by the AllDrugs AI Data-Science Team. It was built from the FDA Structured Product Label (DailyMed) for Refresh Optive Advanced, retrieved March 4, 2026 by a validated AI data-extraction workflow.

All FDA-listed dosage forms and strengths are shown in the Packaging & NDC Codes section above. Regulatory status appears in the Summary Information panel above and was verified in the FDA National Drug Code directory and the NSDE NDC Directory daily file.

Note: an automated daemon monitors NSDE checksums; when the record for this NDC changes, the new file is pulled instantly and this page is refreshed.

No human clinician has reviewed this version.

Learn more in our Editorial Policy

Last AI update: March 4, 2026

Primary FDA sources:

Orange Book data shown on this page are limited to Regulatory Status (Rx), Established Pharmacologic Class (EPC), and Mechanism of Action (MoA).

Regulatory data notice: Information on this page is reproduced verbatim from FDA public databases (NSDE, Orange Book, Purple Book, DailyMed SPL). NDA/ANDA drugs are FDA-approved, BLA biologics are FDA-licensed. Inclusion alone does not guarantee current market availability or imply FDA endorsement.

Medical disclaimer: This AI-generated content is provided for educational purposes only and does not constitute medical advice. Always consult a licensed healthcare professional for diagnosis or treatment decisions.