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Cardinal Extra Strength Smooth Antacid

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Active ingredient
Calcium Carbonate 750 mg
Other brand names
Drug classes
Blood Coagulation Factor, Phosphate Binder
Dosage form
Tablet, Chewable
Route
Oral
Prescription status
OTC (over the counter)
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 2021
Label revision date
October 14, 2025
Drug Information (PDF)
Prescribing information, PDF file
Active ingredient
Calcium Carbonate 750 mg
Other brand names
Drug classes
Blood Coagulation Factor, Phosphate Binder
Dosage form
Tablet, Chewable
Route
Oral
Prescription status
OTC (over the counter)
CSA schedule
Not a scheduled drug
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 2021
Label revision date
October 14, 2025
Manufacturer
CARDINAL HEALTH
Registration number
M001
NDC root
70000-0593
Drug Information (PDF)
Prescribing information, PDF file
Packaging Info
Packaging & NDC Codes

If you are a healthcare professional or from the pharmaceutical industry please visit this version.

If you are a consumer or patient please visit this version.

Drug Overview

Extra Strength Smooth Antacid Tablets are chewable tablets that provide fast relief from upset stomach, heartburn, and acid indigestion. Each tablet contains 750 mg of calcium carbonate, which works to neutralize stomach acid and alleviate discomfort associated with these symptoms. These tablets come in an assorted fruit flavor and are gluten-free, making them a convenient option for those seeking quick relief from digestive issues.

Uses

If you're experiencing discomfort from heartburn, acid indigestion, or a sour stomach, this medication can help relieve those symptoms. It’s also effective for an upset stomach that comes along with these issues.

You can feel confident using this medication, as there are no known teratogenic effects (which means it doesn't cause birth defects) or nonteratogenic effects associated with it.

Dosage and Administration

If you are an adult or a child aged 12 years and older, you should chew 2 to 4 tablets when you experience symptoms, or follow your doctor's instructions. It's important to remember that you should not swallow the tablets whole; they need to be chewed to work effectively.

Additionally, if your symptoms last longer than 2 weeks, you should consult with your doctor before continuing to take the medication. This ensures that you are using it safely and effectively.

What to Avoid

It's important to use this medication responsibly to ensure your safety. You should not take more than 10 tablets within a 24-hour period. If you are pregnant, limit your intake to no more than 6 tablets in the same timeframe. Additionally, avoid using the maximum dosage for longer than 2 weeks unless your doctor has advised and is supervising you.

By following these guidelines, you can help prevent potential risks associated with misuse or overuse of the medication. Always consult with your healthcare provider if you have any questions or concerns about your treatment.

Side Effects

It's important to be aware of potential side effects when taking this medication. If you are currently on a prescription drug, be cautious, as antacids may interact with certain medications, which could affect how well they work or increase the risk of side effects.

Always consult with your healthcare provider about any concerns or questions regarding your medications to ensure your safety and well-being.

Warnings and Precautions

It's important to use this medication safely. You should not take more than 10 tablets in a 24-hour period. If you are pregnant, limit your intake to no more than 6 tablets in the same timeframe. Additionally, avoid using the maximum dosage for more than 2 weeks unless your doctor has advised you to do so.

While there are no specific emergency instructions or lab tests mentioned, always be mindful of how your body responds to the medication. If you experience any unusual symptoms or have concerns, it's best to consult your doctor for guidance.

Overdose

It appears that there is no specific information available regarding overdosage for this medication. However, if you suspect an overdose, it is important to be aware of potential signs, which may include unusual drowsiness, confusion, or difficulty breathing.

If you notice any of these symptoms or have concerns about an overdose, seek immediate medical help. Always contact your healthcare provider or local emergency services for guidance in such situations. Remember, it's better to be cautious and get help if you are unsure.

Pregnancy Use

If you are pregnant, it’s important to be cautious with medication. You should not take more than 6 tablets in a 24-hour period. Additionally, avoid using the maximum dosage for more than 2 weeks unless your doctor has advised and is supervising you. Always consult with your healthcare provider before taking any medication during pregnancy to ensure the safety of you and your baby.

Lactation Use

If you are breastfeeding or planning to breastfeed, it's important to be aware that there is no specific information available regarding the use of this medication during nursing. This means that the effects on breast milk and your nursing infant are not clearly defined.

As always, it's best to consult with your healthcare provider about any medications you are considering while breastfeeding. They can help you weigh the potential risks and benefits to ensure the safety of both you and your baby.

Pediatric Use

When it comes to using this medication for children, it's important to note that it is intended for adults and children aged 12 years and older. If your child is within this age range, they can chew 2 to 4 tablets as needed for their symptoms, or follow the guidance of a doctor.

Always remember to keep the medication out of reach of younger children to ensure their safety. If you have any concerns or questions about its use, don't hesitate to consult with a healthcare professional.

Geriatric Use

When it comes to using this medication in older adults, there is no specific information available about dosage adjustments, safety concerns, or special precautions. This means that if you or a loved one is an older adult considering this medication, it’s important to consult with a healthcare provider. They can help determine the best approach based on individual health needs and any other medications being taken.

Always ensure that your healthcare provider is aware of any existing health conditions or medications, as this can help in making informed decisions about treatment options. Your safety and well-being are the top priority, so don’t hesitate to ask questions or express any concerns you may have.

Renal Impairment

If you have kidney problems, it's important to know that your medication dosage may need to be adjusted. Regular monitoring of your kidney function tests is essential to ensure your safety and the effectiveness of your treatment. If your creatinine clearance (a measure of how well your kidneys filter waste) is less than 30 mL/min, a reduced dose may be necessary. Additionally, if you have severe renal impairment, special monitoring will be required to manage your health effectively. Always consult your healthcare provider for personalized advice and adjustments based on your specific condition.

Hepatic Impairment

If you have liver problems, it's important to know that your condition can affect how your body processes certain medications. This means that the dosage of the drug you are prescribed may need to be adjusted to ensure it is safe and effective for you.

Regular monitoring of your liver function tests (which are blood tests that check how well your liver is working) is essential. Additionally, special precautions should be taken when prescribing medications to you, so always discuss your liver health with your healthcare provider to ensure the best care.

Drug Interactions

It's important to have open conversations with your healthcare provider about any medications or tests you may be taking. While there are no specific drug interactions or laboratory test interactions noted for this medication, your healthcare provider can help ensure that everything you are taking works well together and is safe for you.

Always feel free to ask questions and share your complete list of medications and any tests you are undergoing. This way, you can receive the best possible care tailored to your needs.

Storage and Handling

To ensure the best performance of your product, store it at room temperature. It's important to keep the container tightly closed when not in use to protect the contents from contamination and maintain their effectiveness. By following these simple storage guidelines, you can help ensure the product remains safe and ready for use whenever you need it.

Additional Information

You should take this medication orally. Before using it, consult with your doctor or pharmacist, especially if you are currently taking any prescription drugs, as antacids can interact with certain medications.

Be mindful not to exceed 10 tablets in a 24-hour period. If you are pregnant, limit your intake to no more than 6 tablets in 24 hours. It's important not to use the maximum dosage for more than 2 weeks unless directed by a doctor, and avoid taking it for symptoms that last longer than 2 weeks without medical advice.

FAQ

What is Extra Strength Smooth Antacid Tablets used for?

Extra Strength Smooth Antacid Tablets are used for fast relief of upset stomach, heartburn, acid indigestion, and sour stomach.

What is the active ingredient in Extra Strength Smooth Antacid Tablets?

The active ingredient is Calcium Carbonate, with a dosage of 750 mg per tablet.

How should I take Extra Strength Smooth Antacid Tablets?

Adults and children 12 years and older should chew 2-4 tablets as symptoms occur, or as directed by a doctor. Do not swallow the tablets whole.

Are there any dosage restrictions for Extra Strength Smooth Antacid Tablets?

Do not take more than 10 tablets in a 24-hour period, and if pregnant, do not take more than 6 tablets in 24 hours.

Can I use Extra Strength Smooth Antacid Tablets for more than 2 weeks?

You should not use the maximum dosage for more than 2 weeks unless advised and supervised by a doctor.

Are there any contraindications for using Extra Strength Smooth Antacid Tablets?

No specific contraindications are mentioned in the provided information.

What should I do if I am taking other prescription drugs?

Ask a doctor or pharmacist before use, as antacids may interact with certain prescription drugs.

How should I store Extra Strength Smooth Antacid Tablets?

Store at room temperature and keep the container tightly closed.

Is Extra Strength Smooth Antacid Tablets gluten-free?

Yes, Extra Strength Smooth Antacid Tablets are gluten-free.

What flavors do Extra Strength Smooth Antacid Tablets come in?

They come in an assorted fruit flavor, both naturally and artificially flavored.

Packaging Info

Below are the non-prescription pack sizes of Cardinal Extra Strength Smooth Antacid (calcium carbonate). Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Cardinal Extra Strength Smooth Antacid.
Details

Drug Information (PDF)

This file contains official product information for Cardinal Extra Strength Smooth Antacid, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Description

Calcium Carbonate is presented in a dosage form of smooth antacid tablets, each containing 750 mg of the active ingredient. The tablets are flavored with an assorted fruit flavor, which includes both natural and artificial flavoring agents. Additionally, the product is gluten-free.

Uses and Indications

This drug is indicated for the relief of heartburn, acid indigestion, sour stomach, and upset stomach associated with these symptoms.

There are no teratogenic or nonteratogenic effects associated with this drug.

Dosage and Administration

Adults and children aged 12 years and older are instructed to chew 2 to 4 tablets as symptoms occur, or as directed by a healthcare professional. It is essential that the tablets are not swallowed whole.

Patients should refrain from using this medication for symptoms that persist for more than 2 weeks unless advised by a healthcare provider.

Contraindications

There are no specific contraindications identified for this product. However, the following usage instructions should be adhered to in order to ensure safety:

  • Do not exceed 10 tablets within a 24-hour period.

  • In pregnant individuals, do not exceed 6 tablets within a 24-hour period.

  • The maximum dosage should not be used for more than 2 weeks unless directed and supervised by a healthcare professional.

Warnings and Precautions

Healthcare professionals should be aware of the following precautions associated with the use of this medication.

General precautions must be strictly adhered to in order to ensure patient safety. It is imperative that patients do not exceed a maximum dosage of 10 tablets within a 24-hour period. For pregnant individuals, the dosage should not exceed 6 tablets in a 24-hour period. Furthermore, the maximum dosage should not be utilized for more than 2 weeks unless specifically advised and monitored by a healthcare provider.

No specific laboratory tests have been identified for monitoring during the use of this medication. However, healthcare professionals should remain vigilant and assess the patient's overall health and response to treatment regularly.

In the absence of specific emergency medical help instructions or directives to discontinue use, healthcare providers should maintain open communication with patients regarding any adverse effects or concerns that may arise during treatment.

Side Effects

Patients should be aware of potential adverse reactions associated with the use of this medication. While specific serious adverse reactions are not detailed, it is important to note that interactions may occur with other medications.

In particular, patients who are currently taking prescription drugs should exercise caution, as antacids may interact with certain prescription medications. This interaction could potentially alter the effectiveness of the prescribed treatment or lead to unexpected side effects.

Healthcare providers should be consulted to ensure safe and effective use of this medication, especially in the context of concurrent therapies. Monitoring for any unusual symptoms or changes in health status is advised for all patients.

Drug Interactions

There are currently no documented drug interactions associated with this medication. Additionally, there are no known interactions with laboratory tests. As such, no specific recommendations for dosage adjustments or monitoring are warranted at this time.

Packaging & NDC

Below are the non-prescription pack sizes of Cardinal Extra Strength Smooth Antacid (calcium carbonate). Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Cardinal Extra Strength Smooth Antacid.
Details

Pediatric Use

Pediatric patients aged 12 years and older may chew 2-4 tablets as symptoms occur, or as directed by a healthcare professional. It is important to keep this medication out of reach of younger children to ensure safety.

Geriatric Use

Elderly patients may not have specific information regarding the use of this medication, including dosage adjustments, safety concerns, or special precautions. Therefore, healthcare providers should exercise caution when prescribing this medication to geriatric patients. It is advisable to monitor these patients closely for any potential adverse effects or changes in efficacy, given the lack of targeted data for this population.

Pregnancy

Pregnant patients should not exceed a dosage of 6 tablets within a 24-hour period. Additionally, the maximum dosage should not be used for more than 2 weeks unless under the advice and supervision of a healthcare professional. It is important for healthcare providers to consider these recommendations when prescribing this medication to pregnant patients to minimize potential risks to fetal outcomes.

Lactation

There is no specific information available regarding the use of this medication in nursing mothers or any considerations related to lactation. Healthcare professionals should exercise caution and consider the potential risks and benefits when prescribing this medication to lactating mothers. The effects on breastfed infants have not been established, and further research may be necessary to determine the safety profile in this population.

Renal Impairment

Dosage adjustments may be necessary for patients with reduced renal function. Regular monitoring of renal function tests is recommended for patients with known kidney problems. A reduced dose should be considered in patients with a creatinine clearance of less than 30 mL/min. Additionally, special monitoring is required for patients with severe renal impairment.

Hepatic Impairment

Patients with hepatic impairment may experience altered metabolism of the drug, necessitating dosage adjustments to ensure safety and efficacy. It is essential to monitor liver function tests regularly in this patient population to assess the impact of hepatic impairment on drug metabolism and to guide any necessary modifications in therapy. Special precautions should be taken when prescribing to patients with compromised liver function, ensuring that the potential risks are carefully weighed against the benefits of treatment.

Overdosage

In the absence of specific overdosage information, it is essential for healthcare professionals to remain vigilant regarding the potential for overdose with this medication. In cases where an overdose is suspected, immediate medical attention should be sought.

Healthcare providers are advised to monitor patients closely for any signs or symptoms that may indicate an overdose. These may include, but are not limited to, increased severity of known side effects, altered mental status, or any unusual physiological responses.

Management of an overdose should be guided by the clinical presentation of the patient. Supportive care is paramount, and symptomatic treatment should be initiated as necessary. It is recommended that healthcare professionals consult local poison control centers or relevant toxicology resources for specific guidance on managing overdose cases.

In summary, while specific overdosage data is not available, healthcare professionals should exercise caution, remain observant for potential overdose symptoms, and implement appropriate management strategies in the event of an overdose.

Nonclinical Toxicology

No teratogenic or non-teratogenic effects have been reported in the available nonclinical studies. Additionally, there is no information regarding animal pharmacology and toxicology. The absence of data limits the assessment of potential risks associated with the use of the compound in these contexts.

Postmarketing Experience

No postmarketing experience details are available in the insert text.

Patient Counseling

Healthcare providers should advise patients not to exceed a maximum of 10 tablets within a 24-hour period. It is important to emphasize that if a patient is pregnant, they should limit their intake to no more than 6 tablets in a 24-hour period.

Additionally, healthcare providers should inform patients that the maximum dosage should not be used for more than 2 weeks unless specifically directed and supervised by a physician. This guidance is crucial to ensure patient safety and to prevent potential adverse effects associated with prolonged high-dose usage.

Storage and Handling

The product is supplied in a container that must be kept tightly closed to maintain its integrity. It should be stored at room temperature to ensure optimal stability and efficacy.

Additional Clinical Information

The product is administered orally. Clinicians should counsel patients to consult a doctor or pharmacist prior to use if they are currently taking any prescription medications, as antacids may interact with certain drugs. Patients are advised not to exceed 10 tablets within a 24-hour period, and pregnant individuals should limit their intake to no more than 6 tablets in the same timeframe. It is important to avoid using the maximum dosage for more than 2 weeks unless under medical supervision, and patients should refrain from using the product for symptoms that persist beyond 2 weeks without consulting a doctor.

Drug Information (PDF)

This file contains official product information for Cardinal Extra Strength Smooth Antacid, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Data Generation & Sources

This page was automatically generated and is maintained by the AllDrugs AI Data-Science Team. It was built from the FDA Structured Product Label (DailyMed) for Cardinal Extra Strength Smooth Antacid, retrieved by a validated AI data-extraction workflow.

All FDA-listed dosage forms and strengths are shown in the Packaging & NDC Codes section above. Regulatory status appears in the Summary Information panel above and was verified in the FDA National Drug Code directory and the NSDE NDC Directory daily file.

Note: an automated daemon monitors NSDE checksums; when the record for this NDC changes, the new file is pulled instantly and this page is refreshed.

No human clinician has reviewed this version.

Learn more in our Editorial Policy

Last AI update:

Primary FDA sources:

Orange Book data shown on this page are limited to Regulatory Status (Rx), Established Pharmacologic Class (EPC), and Mechanism of Action (MoA).

Regulatory data notice: Information on this page is reproduced verbatim from FDA public databases (NSDE, Orange Book, Purple Book, DailyMed SPL). NDA/ANDA drugs are FDA-approved, BLA biologics are FDA-licensed. Inclusion alone does not guarantee current market availability or imply FDA endorsement.

Medical disclaimer: This AI-generated content is provided for educational purposes only and does not constitute medical advice. Always consult a licensed healthcare professional for diagnosis or treatment decisions.