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Multi-Symptom Cold

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Active ingredients
  • Guaifenesin 100 mg/5 mL
  • Dextromethorphan Hydrobromide 5 mg/5 mL
  • Phenylephrine Hydrochloride 2.5 mg/5 mL
Other brand names
Drug classes
Expectorant, Sigma-1 Agonist, Uncompetitive N-methyl-D-aspartate Receptor Antagonist, alpha-1 Adrenergic Agonist
Dosage form
Solution
Route
Oral
Prescription status
OTC (over the counter)
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 2023
Label revision date
July 1, 2025
Drug Information (PDF)
Prescribing information, PDF file
Active ingredients
  • Guaifenesin 100 mg/5 mL
  • Dextromethorphan Hydrobromide 5 mg/5 mL
  • Phenylephrine Hydrochloride 2.5 mg/5 mL
Other brand names
Drug classes
Expectorant, Sigma-1 Agonist, Uncompetitive N-methyl-D-aspartate Receptor Antagonist, alpha-1 Adrenergic Agonist
Dosage form
Solution
Route
Oral
Prescription status
OTC (over the counter)
CSA schedule
Not a scheduled drug
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 2023
Label revision date
July 1, 2025
Manufacturer
WALMART INC.
Registration number
M012
NDC root
79903-176
Drug Information (PDF)
Prescribing information, PDF file
Packaging Info
Packaging & NDC Codes

If you are a healthcare professional or from the pharmaceutical industry please visit this version.

If you are a consumer or patient please visit this version.

Drug Overview

Equate™ Children's Multi-Symptom Cold is an oral solution designed for children aged 4 to 11 years. This berry-flavored medication contains three active ingredients: dextromethorphan HBr (a cough suppressant), guaifenesin (an expectorant that helps loosen phlegm), and phenylephrine HCl (a nasal decongestant). Together, these ingredients work to temporarily relieve symptoms associated with the common cold, such as cough, stuffy nose, and nasal congestion.

The formulation helps to break up mucus and makes coughs more productive by thinning bronchial secretions, which can ease discomfort and help your child sleep better. This product is intended to provide relief from the bothersome symptoms of a cold, allowing your child to feel more comfortable.

Uses

This medication is designed to help you breathe easier by loosening phlegm (mucus) and thinning bronchial secretions. This action helps clear out bothersome mucus from your airways, making your coughs more productive.

You can also use this medication to temporarily relieve symptoms such as cough caused by minor throat and bronchial irritation, which can happen with the common cold or from inhaling irritants. It can help with a stuffy nose and nasal congestion due to a cold, reduce the intensity of your cough, and lessen the urge to cough, making it easier for you or your child to get to sleep.

Dosage and Administration

It's important to follow the dosage instructions carefully to ensure safety and effectiveness. You should never take more than the directed amount, and make sure not to exceed 6 doses within a 24-hour period. Always use the dose cup that comes with the medication for accurate measurement.

For children aged 6 to under 12 years, the recommended dose is 10 mL every 4 hours. If your child is between 4 and under 6 years old, the dose is 5 mL every 4 hours. However, if your child is under 4 years old, you should not use this medication. Always consult with a doctor if you have any questions or concerns about the appropriate dosage for your child.

What to Avoid

You should avoid using this medication in children who are currently taking a prescription monoamine oxidase inhibitor (MAOI), which is a type of medication used for depression, psychiatric conditions, or Parkinson’s disease. Additionally, do not give this medication to a child for at least two weeks after stopping an MAOI. If you are unsure whether your child's prescription includes an MAOI, please consult a doctor or pharmacist.

It's also important to follow the recommended dosage and not exceed it. Taking more than the advised amount can lead to serious health risks. Always prioritize safety and consult with a healthcare professional if you have any questions or concerns.

Side Effects

If you experience nervousness, dizziness, or sleeplessness while using this medication, it's important to stop using it and consult your doctor. Additionally, if your symptoms do not improve within 7 days, or if they occur alongside a fever, you should seek medical advice. A cough that lasts more than a week, keeps coming back, or is accompanied by a fever, rash, or persistent headache may indicate a more serious health issue, and you should contact your healthcare provider.

Warnings and Precautions

You should not give this medication to a child who is currently taking a monoamine oxidase inhibitor (MAOI), which is a type of prescription drug used for depression or certain other conditions, or for two weeks after stopping an MAOI. If you're unsure whether your child's medication includes an MAOI, please consult a doctor or pharmacist.

Before using this product, it's important to talk to a doctor if your child has any of the following conditions: diabetes, heart disease, thyroid disease, high blood pressure, a chronic cough (like asthma), or a cough with excessive mucus. If your child experiences an overdose, seek medical help or contact a Poison Control Center immediately.

You should stop using this medication and call your doctor if your child experiences nervousness, dizziness, or sleeplessness, if symptoms do not improve within seven days or are accompanied by a fever, or if a cough lasts more than a week, recurs, or is accompanied by a fever, rash, or persistent headache, as these may indicate a more serious issue.

Overdose

If you suspect an overdose, it’s crucial to seek medical help immediately or contact a Poison Control Center. Signs of an overdose can vary, but they may include unusual symptoms that are more severe than typical side effects.

Always err on the side of caution—if you notice anything concerning, don’t hesitate to reach out for assistance. Quick action can make a significant difference in ensuring your safety and well-being.

Pregnancy Use

If you are pregnant or planning to become pregnant, it's important to know that the safety of this medication during pregnancy has not been established. You should not use it unless your healthcare provider specifically directs you to do so. There may be potential risks to your fetus, but these risks are not well defined, so it's crucial to consult your healthcare provider for personalized advice.

Additionally, if you are prescribed this medication, your healthcare provider may need to adjust the dosage based on your individual situation. Always weigh the potential benefits against the possible risks to your fetus before using this medication during pregnancy.

Lactation Use

If you are breastfeeding, you can feel reassured that there are no specific warnings or recommendations regarding the use of this product while nursing. Additionally, there is no information available about whether this product is excreted in breast milk or any potential risks to your infant.

As always, if you have any concerns or questions about using this product while breastfeeding, it's a good idea to consult with your healthcare provider for personalized advice.

Pediatric Use

It's important to be cautious when giving medication to children. You should not use this medication if your child is currently taking a prescription monoamine oxidase inhibitor (MAOI) or has stopped taking one within the last two weeks. Before using it, consult your doctor if your child has any of the following conditions: diabetes, heart disease, thyroid disease, high blood pressure, a persistent cough (like asthma), or a cough with excessive mucus.

For dosing, children aged 6 to under 12 years can take 10 mL every 4 hours, while those aged 4 to under 6 years should take 5 mL every 4 hours. It’s crucial not to give this medication to children under 4 years old and to never exceed the recommended dosage. Always keep the medication out of reach of children, and if an overdose occurs, seek medical help or contact a Poison Control Center immediately.

Geriatric Use

When it comes to using this medication in older adults, there is no specific information available regarding its safety or effectiveness. This means that if you or a loved one is an older adult, it’s important to consult with a healthcare provider before starting the medication. They can help assess any individual health needs and consider any potential risks or benefits based on your overall health and any other medications you may be taking. Always prioritize open communication with your healthcare team to ensure the best care.

Renal Impairment

If you have kidney problems, it's important to know that the drug insert does not provide specific information about dosage adjustments, special monitoring, or safety considerations for your condition. This means that there are no tailored guidelines for how this medication should be used if you have renal impairment (kidney issues).

Always consult your healthcare provider for personalized advice and to ensure that any medication you take is safe and appropriate for your health situation. They can help you understand how to manage your treatment effectively while considering your kidney health.

Hepatic Impairment

If you have liver problems, it's important to know that the drug insert does not provide specific information about dosage adjustments, special monitoring, or precautions for your condition. This means that there are no tailored guidelines for how this medication may affect you if you have hepatic impairment (issues with liver function).

Before starting any new medication, including this one, you should discuss your liver health with your healthcare provider. They can help determine the best approach for your treatment and ensure your safety.

Drug Interactions

It's important to be cautious when giving certain medications to children, especially if they are taking a prescription monoamine oxidase inhibitor (MAOI). MAOIs are specific drugs used to treat depression, psychiatric conditions, or Parkinson’s disease. You should not use this product in a child who is currently taking an MAOI or for at least two weeks after stopping it. If you're unsure whether your child's medication includes an MAOI, it's best to consult with a doctor or pharmacist before proceeding.

Always discuss any medications or treatments with your healthcare provider to ensure safety and avoid potential interactions. Your provider can help you understand the risks and make informed decisions about your child's health.

Storage and Handling

To ensure the best performance of your product, store it at a temperature of 25°C (77°F). It can safely be kept within a range of 15°-30°C (59°-86°F) for short periods. Always check the end flap for the expiration date and lot number to confirm its validity before use.

When handling the product, make sure to do so in a clean environment to maintain its integrity. Proper storage and careful handling are essential for safety and effectiveness, so please follow these guidelines closely.

Additional Information

There is no additional information available regarding laboratory tests, administration methods, patient counseling, or postmarketing experiences for this medication.

If you are concerned about the potential for medicine abuse, especially among teens, you can find helpful resources at www.StopMedicineAbuse.orgwww.StopMedicineAbuse.org.

FAQ

What is equate™ children's MULTI-SYMPTOM COLD?

It is an oral solution designed for children ages 4 to 11 years, containing Dextromethorphan HBr (cough suppressant), Guaifenesin (expectorant), and Phenylephrine HCl (nasal decongestant).

What symptoms does this medication relieve?

It temporarily relieves cough due to minor throat and bronchial irritation, stuffy nose, nasal congestion due to a cold, and helps reduce the intensity of coughing.

What is the recommended dosage for children?

For children 6 to under 12 years, the dosage is 10 mL every 4 hours; for children 4 to under 6 years, it is 5 mL every 4 hours. Do not use in children under 4 years.

Are there any contraindications for using this medication?

Do not use in children taking a prescription monoamine oxidase inhibitor (MAOI) or for 2 weeks after stopping an MAOI. Consult a doctor if unsure.

What should I do if my child experiences side effects?

Stop use and ask a doctor if nervousness, dizziness, or sleeplessness occur, or if symptoms do not improve within 7 days or are accompanied by fever.

Is it safe to use during pregnancy?

Safety during pregnancy has not been established; consult a healthcare provider before use.

How should this medication be stored?

Store at 25°C (77°F), with permitted excursions between 15°-30°C (59°-86°F).

What should I do in case of an overdose?

Get medical help or contact a Poison Control Center immediately.

Packaging Info

Below are the non-prescription pack sizes of Multi-Symptom Cold (dextromethorphan hbr, guaifenesin, phenylephrine hcl). Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Multi-Symptom Cold.
Details

Drug Information (PDF)

This file contains official product information for Multi-Symptom Cold, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Description

Equate™ children's MULTI-SYMPTOM COLD is an oral solution formulated for children aged 4 to 11 years. The active ingredients include Dextromethorphan HBr, a cough suppressant; Guaifenesin, an expectorant; and Phenylephrine HCl, a nasal decongestant. The product is presented in a berry flavor and is packaged in a 6.8 FL OZ (201 mL) bottle, which includes a dosage cup for accurate measurement. A tamper evident warning is provided, stating that the product should not be used if the printed neck wrap is broken or missing. This product is distributed by Walmart Inc., located in Bentonville, AR 72716.

Uses and Indications

This drug is indicated for the relief of cough and nasal congestion associated with minor throat and bronchial irritation, which may occur due to the common cold or inhaled irritants. It aids in loosening phlegm (mucus) and thinning bronchial secretions, thereby facilitating the expulsion of bothersome mucus and enhancing the productivity of coughs.

Additionally, this drug temporarily relieves symptoms such as a stuffy nose, nasal congestion due to a cold, and the intensity and impulse to cough, which may assist children in achieving restful sleep.

There are no teratogenic or nonteratogenic effects associated with this drug.

Dosage and Administration

Healthcare professionals should advise patients to adhere strictly to the recommended dosage and administration guidelines. The maximum dosage should not exceed the specified limits, and no more than six doses should be administered within a 24-hour period. It is essential to utilize only the dose cup provided with the medication for accurate measurement.

For children aged 6 to under 12 years, the recommended dosage is 10 mL every 4 hours as needed. For children aged 4 to under 6 years, the appropriate dosage is 5 mL every 4 hours. The medication is not recommended for use in children under 4 years of age.

Healthcare professionals should ensure that patients understand these guidelines and the importance of following them to avoid potential overdose or adverse effects.

Contraindications

Use of this product is contraindicated in children who are currently taking a prescription monoamine oxidase inhibitor (MAOI) or within 2 weeks of discontinuing such medication. MAOIs are typically prescribed for depression, psychiatric or emotional conditions, or Parkinson’s disease. If there is uncertainty regarding the presence of an MAOI in a child's prescription, consultation with a healthcare professional is advised prior to administration of this product.

Additionally, it is contraindicated to exceed the recommended dosage.

Warnings and Precautions

It is imperative to adhere to the following warnings and precautions when considering the use of this product in pediatric patients.

Warnings This product must not be administered to children who are currently taking a prescription monoamine oxidase inhibitor (MAOI), which includes certain medications prescribed for depression, psychiatric or emotional conditions, or Parkinson’s disease. Additionally, it should not be used for a period of two weeks following the cessation of an MAOI. If there is uncertainty regarding whether a child’s prescription includes an MAOI, it is essential to consult a healthcare professional, such as a doctor or pharmacist, prior to administration.

General Precautions Prior to use, it is advisable to consult a healthcare provider if the child has any of the following conditions:

  • Diabetes

  • Heart disease

  • Thyroid disease

  • High blood pressure

  • A persistent or chronic cough, particularly one associated with asthma

  • A cough that produces excessive phlegm (mucus)

Emergency Medical Help Instructions In the event of an overdose, immediate medical assistance should be sought, or contact with a Poison Control Center should be established without delay.

Stop Taking and Call Your Doctor Instructions The use of this product should be discontinued and a healthcare provider should be contacted if any of the following occur:

  • Nervousness, dizziness, or sleeplessness

  • Symptoms do not improve within seven days or are accompanied by fever

  • A cough persists for more than one week, recurs, or is associated with fever, rash, or a persistent headache, as these may indicate a serious underlying condition.

Side Effects

Patients should discontinue use and consult a healthcare professional if they experience nervousness, dizziness, or sleeplessness. Additionally, if symptoms do not improve within 7 days or are accompanied by fever, medical advice should be sought. A persistent cough lasting more than one week, especially if it recurs or is associated with fever, rash, or a persistent headache, may indicate a serious underlying condition and warrants immediate medical evaluation.

Drug Interactions

The concomitant use of this product with monoamine oxidase inhibitors (MAOIs) is contraindicated in pediatric patients. MAOIs are typically prescribed for the treatment of depression, certain psychiatric conditions, or Parkinson’s disease. Administration of this product should be avoided in children who are currently taking an MAOI or within 14 days of discontinuing such therapy.

Healthcare professionals are advised to confirm whether a child's prescription includes an MAOI prior to the administration of this product. If there is any uncertainty regarding the presence of an MAOI in the child's medication regimen, consultation with a physician or pharmacist is strongly recommended to ensure patient safety.

Packaging & NDC

Below are the non-prescription pack sizes of Multi-Symptom Cold (dextromethorphan hbr, guaifenesin, phenylephrine hcl). Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Multi-Symptom Cold.
Details

Pediatric Use

Pediatric patients should not use this medication if they are currently taking a prescription monoamine oxidase inhibitor (MAOI) or within 2 weeks of discontinuing an MAOI. Prior to administration, it is advisable to consult a healthcare professional if the child has any of the following conditions: diabetes, heart disease, thyroid disease, high blood pressure, persistent or chronic cough (such as that associated with asthma), or cough accompanied by excessive phlegm.

Dosage recommendations for pediatric patients are as follows: for children aged 6 to under 12 years, the recommended dose is 10 mL every 4 hours; for children aged 4 to under 6 years, the dose is 5 mL every 4 hours. The medication is not recommended for children under 4 years of age. It is crucial not to exceed the recommended dosage, and the product should be kept out of reach of children. In the event of an overdose, immediate medical assistance should be sought or contact with a Poison Control Center should be made.

Geriatric Use

There is no specific information regarding the use of this medication in geriatric patients. Therefore, healthcare providers should exercise caution when prescribing this medication to elderly patients. It is advisable to monitor this population closely for any potential adverse effects or changes in efficacy, as age-related physiological changes may influence drug metabolism and response. Additionally, consideration should be given to the presence of comorbidities and polypharmacy, which are common in geriatric patients and may necessitate dosage adjustments or increased monitoring.

Pregnancy

Safety during pregnancy has not been established for this medication. It is contraindicated in pregnant patients unless directed by a healthcare provider. The potential risks to the fetus are not well defined; therefore, it is essential for healthcare providers to be consulted for personalized advice regarding use during pregnancy.

Dosage adjustments may be necessary for pregnant patients, and specific recommendations should be obtained from a healthcare provider. Special precautions should be taken, as the medication should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus.

Lactation

There are no specific warnings or recommendations regarding the use of this product in nursing mothers. Additionally, there is no information available about the potential for excretion in breast milk or any associated risks to breastfed infants.

Renal Impairment

Patients with renal impairment have no specific information regarding dosage adjustments, special monitoring, or safety considerations provided in the drug insert. Therefore, healthcare professionals should exercise caution when prescribing this medication to individuals with reduced kidney function, as the lack of data necessitates careful clinical judgment. Regular monitoring of renal function may be advisable in these patients to ensure safety and efficacy.

Hepatic Impairment

Patients with hepatic impairment have not been specifically studied in relation to this drug. Consequently, there are no dosage adjustments, special monitoring requirements, or precautions outlined for individuals with compromised liver function. It is recommended that healthcare providers exercise caution when prescribing this medication to patients with hepatic impairment, given the lack of data on its safety and efficacy in this population. Regular monitoring of liver function may be prudent in these cases, although specific parameters are not defined in the prescribing information.

Overdosage

In the event of an overdose, it is imperative to seek immediate medical assistance or contact a Poison Control Center without delay. Prompt intervention is crucial to mitigate potential adverse effects associated with the overdose.

Healthcare professionals should be vigilant in monitoring for symptoms that may arise from an overdose. While specific symptoms are not detailed in the provided information, it is essential to assess the patient for any signs of toxicity or distress.

Management of an overdose should be guided by established protocols, which may include supportive care and symptomatic treatment as necessary. Continuous evaluation of the patient's condition is recommended to ensure appropriate interventions are implemented in a timely manner.

Nonclinical Toxicology

No teratogenic or non-teratogenic effects have been reported in the available nonclinical studies. Additionally, there is no information regarding animal pharmacology and toxicology. The absence of data limits the assessment of potential risks associated with the compound in these areas.

Postmarketing Experience

Postmarketing experience has been gathered through voluntary reports and surveillance programs. Healthcare professionals and patients are encouraged to report any undesired reactions or side effects associated with the use of the product. For inquiries or to report such events, individuals may contact 1-888-287-1915.

Patient Counseling

Healthcare providers should advise patients to seek immediate medical assistance or contact a Poison Control Center in the event of an overdose. It is crucial to inform patients that this product should not be used in children who are currently taking a prescription monoamine oxidase inhibitor (MAOI) or within two weeks of stopping such medication. If patients are uncertain whether their child's prescription includes an MAOI, they should be encouraged to consult a doctor or pharmacist prior to administering this product.

Patients should be instructed to discontinue use and consult a doctor if they experience nervousness, dizziness, or sleeplessness. Additionally, they should be informed that if symptoms do not improve within seven days, or if they occur alongside a fever, medical advice should be sought. Persistent cough lasting more than one week, recurrent cough, or cough accompanied by fever, rash, or a persistent headache may indicate a serious condition, warranting further evaluation.

While using this product, patients must be reminded not to exceed the recommended dosage. Furthermore, healthcare providers should recommend that patients consult a doctor before use if the child has any of the following conditions: diabetes, heart disease, thyroid disease, high blood pressure, a persistent or chronic cough such as that associated with asthma, or a cough that produces excessive phlegm (mucus).

Storage and Handling

The product is supplied in various package configurations, with specific NDC numbers available upon request. It should be stored at a controlled room temperature of 25°C (77°F), with permissible excursions between 15°C and 30°C (59°F to 86°F).

Healthcare professionals are advised to check the end flap of the packaging for the expiration date and lot number to ensure proper inventory management and product safety.

Additional Clinical Information

No further data are available.

Drug Information (PDF)

This file contains official product information for Multi-Symptom Cold, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Data Generation & Sources

This page was automatically generated and is maintained by the AllDrugs AI Data-Science Team. It was built from the FDA Structured Product Label (DailyMed) for Multi-Symptom Cold, retrieved by a validated AI data-extraction workflow.

All FDA-listed dosage forms and strengths are shown in the Packaging & NDC Codes section above. Regulatory status appears in the Summary Information panel above and was verified in the FDA National Drug Code directory and the NSDE NDC Directory daily file.

Note: an automated daemon monitors NSDE checksums; when the record for this NDC changes, the new file is pulled instantly and this page is refreshed.

No human clinician has reviewed this version.

Learn more in our Editorial Policy

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Primary FDA sources:

Orange Book data shown on this page are limited to Regulatory Status (Rx), Established Pharmacologic Class (EPC), and Mechanism of Action (MoA).

Regulatory data notice: Information on this page is reproduced verbatim from FDA public databases (NSDE, Orange Book, Purple Book, DailyMed SPL). NDA/ANDA drugs are FDA-approved, BLA biologics are FDA-licensed. Inclusion alone does not guarantee current market availability or imply FDA endorsement.

Medical disclaimer: This AI-generated content is provided for educational purposes only and does not constitute medical advice. Always consult a licensed healthcare professional for diagnosis or treatment decisions.