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Tussin Multi Symptom Cold Cf

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Active ingredients
  • Guaifenesin 200 mg/10 mL
  • Dextromethorphan Hydrobromide 20 mg/10 mL
  • Phenylephrine Hydrochloride 10 mg/10 mL
Other brand names
Drug classes
Expectorant, Sigma-1 Agonist, Uncompetitive N-methyl-D-aspartate Receptor Antagonist, alpha-1 Adrenergic Agonist
Dosage form
Liquid
Route
Oral
Prescription status
OTC (over the counter)
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 2015
Label revision date
December 17, 2025
Drug Information (PDF)
Prescribing information, PDF file
Active ingredients
  • Guaifenesin 200 mg/10 mL
  • Dextromethorphan Hydrobromide 20 mg/10 mL
  • Phenylephrine Hydrochloride 10 mg/10 mL
Other brand names
Drug classes
Expectorant, Sigma-1 Agonist, Uncompetitive N-methyl-D-aspartate Receptor Antagonist, alpha-1 Adrenergic Agonist
Dosage form
Liquid
Route
Oral
Prescription status
OTC (over the counter)
CSA schedule
Not a scheduled drug
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 2015
Label revision date
December 17, 2025
Manufacturer
Major Pharmaceuticals
Registration number
M012
NDC root
0904-6537
Drug Information (PDF)
Prescribing information, PDF file
Packaging Info
Packaging & NDC Codes

If you are a healthcare professional or from the pharmaceutical industry please visit this version.

If you are a consumer or patient please visit this version.

Drug Overview

Robafen CF is a multi-symptom cold medication designed to temporarily relieve symptoms associated with colds, such as nasal congestion, cough, and mucus buildup. It contains three active ingredients: dextromethorphan HBr (20 mg), which acts as a cough suppressant; guaifenesin (200 mg), an expectorant that helps loosen phlegm and thin bronchial secretions; and phenylephrine HCl (10 mg), a nasal decongestant that helps relieve nasal congestion.

By working together, these ingredients help you feel more comfortable when you're dealing with a cold, making it easier to breathe and reducing coughing caused by minor throat and bronchial irritation. Robafen CF is suitable for individuals aged 12 and over and is alcohol-free.

Uses

This medication is designed to help you breathe easier by loosening phlegm (mucus) and thinning bronchial secretions, which allows for better drainage of your bronchial tubes. If you're experiencing symptoms from a cold, such as nasal congestion or a cough caused by minor irritation in your throat and bronchial area, this medication can provide temporary relief.

It's important to note that there are no reported teratogenic effects (which means it doesn't cause birth defects) associated with this medication, making it a safer option for those concerned about such risks.

Dosage and Administration

When using this medication, it's important to follow the dosing instructions carefully. For adults and children aged 12 years and older, you should take 10 milliliters (mL) every 4 hours, but make sure not to exceed 6 doses in a 24-hour period. To ensure accurate dosing, always use the dosing cup that comes with the product; do not use any other measuring device.

If you are considering this medication for a child under 12 years of age, please do not use it, as it is not intended for that age group. Keep the dosing cup with the product to make it easy for you to measure the correct amount each time you take your dose.

What to Avoid

You should avoid using this product if you are currently taking a prescription monoamine oxidase inhibitor (MAOI), which is a type of medication often prescribed for depression, psychiatric conditions, or Parkinson’s disease. Additionally, do not use this product for at least two weeks after stopping an MAOI. If you're unsure whether your medication contains an MAOI, please consult your doctor or pharmacist.

It's also important to follow the dosage instructions carefully. Do not exceed the recommended amount, as using more than directed can lead to serious health risks, including potential misuse or dependence (a condition where your body becomes reliant on a substance). Always prioritize your safety and well-being when using any medication.

Side Effects

If you experience nervousness, dizziness, or trouble sleeping while using this medication, it's important to stop using it and consult your doctor. Additionally, if your symptoms do not improve within 7 days, or if they are accompanied by a fever, you should seek medical advice. A cough that lasts more than 7 days, returns, or is accompanied by fever, rash, or a persistent headache may indicate a more serious condition, and you should contact your healthcare provider.

Warnings and Precautions

You should not use this product if you are currently taking a prescription monoamine oxidase inhibitor (MAOI) for depression, psychiatric conditions, or Parkinson’s disease, or if you have stopped taking an MAOI within the last two weeks. If you are unsure whether your medication contains an MAOI, please consult your doctor or pharmacist.

Before using this product, it’s important to talk to your doctor if you have any of the following conditions: heart disease, high blood pressure, diabetes, thyroid issues, difficulty urinating due to an enlarged prostate, or a cough that produces a lot of mucus or lasts a long time (such as from smoking, asthma, chronic bronchitis, or emphysema). Additionally, check with your doctor or pharmacist if you are taking any other oral nasal decongestants or stimulants.

If you experience an overdose, seek emergency medical help immediately or contact a Poison Control Center at 1-800-222-1222. You should also stop using the product and call your doctor if you feel nervous, dizzy, or unable to sleep, if your symptoms do not improve within 7 days, or if your cough lasts more than 7 days, returns, or is accompanied by fever, rash, or a persistent headache, as these may indicate a more serious condition.

Overdose

If you suspect an overdose, it’s crucial to seek medical help immediately. You can contact a Poison Control Center at 1-800-222-1222 for guidance. Signs of an overdose can vary, but they may include unusual drowsiness, confusion, or difficulty breathing.

Always err on the side of caution—if you notice any concerning symptoms or if you’re unsure, don’t hesitate to get help right away. Your health and safety are the top priority.

Pregnancy Use

If you are pregnant or breastfeeding, it’s important to consult with a healthcare professional before using this medication. They can provide guidance on whether it’s safe for you and your baby. Always prioritize your health and the health of your child by seeking expert advice.

Lactation Use

If you are pregnant or breastfeeding, it’s important to consult with a healthcare professional before using any medication. This ensures that you understand any potential risks and can make informed decisions about your health and the health of your baby. Always prioritize open communication with your doctor regarding your breastfeeding journey.

Pediatric Use

This product is designed for adults and children aged 12 years and older. If your child is 12 years or older, the recommended dosage is 10 mL every 4 hours as needed. However, it is important to note that this product should not be used in children under 12 years of age. Always consult with a healthcare professional if you have any questions or concerns about using this medication for your child.

Geriatric Use

This medication is designed for adults and is not suitable for children under 12 years old. If you are 12 years or older, the recommended dosage is 10 mL every 4 hours, but be sure not to exceed 6 doses in a 24-hour period.

As you consider this medication for older adults, it's important to follow these guidelines closely to ensure safety and effectiveness. Always consult with a healthcare provider if you have any questions or concerns about its use, especially if there are any existing health conditions.

Renal Impairment

If you have kidney problems, it's important to know that the drug insert does not provide specific information about dosage adjustments, special monitoring, or safety considerations for your condition. This means that there are no tailored guidelines for how this medication may affect you if you have renal impairment (kidney issues).

Always consult your healthcare provider for personalized advice and to ensure that any medication you take is safe and appropriate for your health situation. They can help monitor your kidney function and make any necessary adjustments to your treatment plan.

Hepatic Impairment

If you have liver problems, it's important to know that the drug insert does not provide specific information about dosage adjustments, special monitoring, or precautions for your condition. This means that there are no tailored guidelines for how this medication should be used if you have hepatic impairment (liver issues).

Before starting any new medication, including this one, you should discuss your liver health with your healthcare provider. They can help determine the best approach for your treatment and ensure your safety.

Drug Interactions

It's important to be cautious when taking certain medications. If you are currently using a prescription monoamine oxidase inhibitor (MAOI), or if you have stopped taking one within the last two weeks, you should avoid using this medication. Taking them together can lead to serious interactions that may affect your health.

Always discuss any medications you are taking with your healthcare provider, including any recent changes. This ensures that you can safely manage your treatment and avoid potential complications. Your health and safety are the top priority, so open communication with your provider is key.

Storage and Handling

To ensure the best performance of your product, store it at room temperature, specifically between 20-25°C (68°-77°F). It's important not to refrigerate the product, as this could affect its effectiveness.

When handling the product, make sure to do so in a clean environment to maintain its integrity. Always follow any additional safety instructions provided to ensure safe use and disposal.

Additional Information

You should take this medication orally, with a recommended dose of 10 mL every 4 hours for adults and children aged 12 years and older. However, do not exceed 6 doses in a 24-hour period. If you are pregnant or breastfeeding, consult a healthcare professional before using this medication.

It's important to keep this medicine out of reach of children. In the event of an overdose, seek medical help immediately or contact a Poison Control Center at 1-800-222-1222.

FAQ

What is robafen CF used for?

Robafen CF is a multi-symptom cold medication that temporarily relieves nasal congestion and cough due to minor throat and bronchial irritation.

What are the active ingredients in robafen CF?

The active ingredients are dextromethorphan HBr (20 mg), guaifenesin (200 mg), and phenylephrine HCl (10 mg).

Who can use robafen CF?

This product is intended for adults and children aged 12 years and over. It should not be used in children under 12 years of age.

How should I take robafen CF?

You should take 10 mL every 4 hours, and do not exceed 6 doses in any 24-hour period. Use only the dosing cup provided.

Are there any warnings associated with robafen CF?

Do not use if you are taking a prescription monoamine oxidase inhibitor (MAOI) or for 2 weeks after stopping an MAOI. Consult a doctor if you have certain health conditions.

What should I do if I experience side effects?

Stop use and ask a doctor if you experience nervousness, dizziness, sleeplessness, or if symptoms do not improve within 7 days.

Is robafen CF safe to use during pregnancy or breastfeeding?

If you are pregnant or breastfeeding, you should ask a health professional before using robafen CF.

How should robafen CF be stored?

Store robafen CF between 20-25°C (68°-77°F) and do not refrigerate.

What should I do in case of an overdose?

In case of overdose, get medical help or contact a Poison Control Center immediately at 1-800-222-1222.

Packaging Info

Below are the non-prescription pack sizes of Tussin Multi Symptom Cold Cf (dextromethorphan hbr, guaifenesin, phenylephrine). Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Tussin Multi Symptom Cold Cf.
Details

Drug Information (PDF)

This file contains official product information for Tussin Multi Symptom Cold Cf, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Description

No description information is available for the specified drug.

Uses and Indications

This drug is indicated for the relief of symptoms associated with colds, specifically nasal congestion and cough due to minor throat and bronchial irritation. It aids in loosening phlegm (mucus) and thinning bronchial secretions, facilitating drainage of the bronchial tubes.

There are no teratogenic or nonteratogenic effects associated with this drug.

Dosage and Administration

The recommended dosage for adults and children aged 12 years and older is 10 mL administered every 4 hours as needed. It is imperative that no more than 6 doses are taken within a 24-hour period.

Healthcare professionals should instruct patients to measure the dosage exclusively with the dosing cup provided with the product, as the use of any other dosing device is not advised. The dosing cup should be kept with the product to ensure proper measurement.

This product is not intended for use in children under 12 years of age; therefore, it is contraindicated for this population.

Contraindications

Use of this product is contraindicated in patients currently taking a prescription monoamine oxidase inhibitor (MAOI), which includes certain medications for depression, psychiatric or emotional conditions, or Parkinson’s disease. Additionally, use is contraindicated for 2 weeks following the discontinuation of an MAOI. Patients should consult a healthcare professional if uncertain whether their prescription contains an MAOI.

Exceeding the recommended dosage is also contraindicated while using this product.

Warnings and Precautions

It is imperative to adhere to the following warnings and precautions to ensure the safe use of this product.

Warnings The use of this product is contraindicated in individuals currently taking a prescription monoamine oxidase inhibitor (MAOI), which includes certain medications prescribed for depression, psychiatric or emotional conditions, or Parkinson’s disease. Additionally, this product should not be used for a period of two weeks following the discontinuation of an MAOI. If there is uncertainty regarding whether a prescription medication contains an MAOI, it is essential to consult a healthcare professional, such as a doctor or pharmacist, prior to use.

General Precautions Prior to using this product, individuals should seek medical advice if they have any of the following conditions: heart disease, high blood pressure, diabetes, thyroid disorders, difficulty urinating due to an enlarged prostate gland, or a cough associated with excessive phlegm (mucus). Furthermore, individuals with a chronic cough, such as that which may occur with smoking, asthma, chronic bronchitis, or emphysema, should also consult a healthcare provider. It is advisable to discuss the use of this product with a doctor or pharmacist if the individual is currently taking any other oral nasal decongestants or stimulants.

Emergency Medical Help In the event of an overdose, immediate medical assistance should be sought, or contact a Poison Control Center at 1-800-222-1222 without delay.

Discontinuation and Consultation Users should discontinue use and consult a healthcare professional if they experience nervousness, dizziness, or sleeplessness. Additionally, if symptoms do not improve within seven days or are accompanied by fever, or if a cough persists for more than seven days, recurs, or is accompanied by fever, rash, or a persistent headache, medical advice should be sought, as these may indicate a serious condition.

Side Effects

Patients should discontinue use and consult a healthcare professional if they experience nervousness, dizziness, or sleeplessness. Additionally, if symptoms do not improve within 7 days or are accompanied by fever, medical advice should be sought. A cough that persists for more than 7 days, recurs, or is associated with fever, rash, or a persistent headache may indicate a serious underlying condition and warrants immediate medical attention.

Drug Interactions

The concomitant use of this medication with prescription monoamine oxidase inhibitors (MAOIs) is contraindicated. Patients should not take this medication while on MAOIs or for a period of two weeks following the discontinuation of MAOI therapy, as this may result in serious interactions.

No additional drug interactions or laboratory test interactions have been identified for this medication. Therefore, no further dosage adjustments or monitoring recommendations are necessary beyond the contraindication with MAOIs.

Packaging & NDC

Below are the non-prescription pack sizes of Tussin Multi Symptom Cold Cf (dextromethorphan hbr, guaifenesin, phenylephrine). Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Tussin Multi Symptom Cold Cf.
Details

Pediatric Use

This product is not intended for use in pediatric patients under 12 years of age. For patients aged 12 years and older, the recommended dosage is 10 mL every 4 hours. There are no established safety or efficacy data for children under 12 years.

Geriatric Use

Elderly patients should be aware that this product is not intended for use in children under 12 years of age. For adult patients, including those aged 65 and older, the recommended dosage is 10 mL every 4 hours, with a maximum of 6 doses in any 24-hour period.

Caution is advised when administering this product to geriatric patients, as they may have altered pharmacokinetics and pharmacodynamics. It is important to monitor for potential adverse effects and to consider individual patient factors, such as renal function and the presence of comorbidities, which may necessitate dose adjustments.

Pregnancy

Pregnant patients and those who are breastfeeding should consult a healthcare professional prior to using this medication. It is important to assess the potential risks and benefits, as well as any available data regarding fetal outcomes and lactation. Healthcare providers should consider individual circumstances and the specific needs of the patient when making recommendations.

Lactation

Lactating mothers are advised to consult a health professional prior to using this medication. There is currently no available data regarding the excretion of this medication in human breast milk or its effects on breastfed infants. Therefore, caution is recommended when administering this medication to lactating individuals.

Renal Impairment

Patients with renal impairment have not been specifically addressed in the drug insert text regarding dosage adjustments, special monitoring, or safety considerations. Therefore, healthcare professionals should exercise caution when prescribing this medication to individuals with reduced kidney function, as there is no available data to guide treatment decisions in this population. Regular monitoring of renal function may be prudent in these patients, although specific recommendations are not provided.

Hepatic Impairment

Patients with hepatic impairment have not been specifically studied in relation to this medication. Consequently, there are no dosage adjustments, special monitoring requirements, or precautions outlined for individuals with compromised liver function. It is recommended that healthcare providers exercise caution when prescribing this medication to patients with hepatic impairment, given the lack of data on its safety and efficacy in this population. Regular monitoring of liver function may be prudent in these cases, although specific parameters are not defined in the prescribing information.

Overdosage

In the event of an overdose, it is imperative to seek immediate medical assistance. Healthcare professionals are advised to contact a Poison Control Center at 1-800-222-1222 for guidance on managing the situation effectively.

Prompt intervention is crucial to mitigate potential adverse effects associated with overdose. The specific symptoms of overdose may vary depending on the substance involved; therefore, a thorough assessment and appropriate management strategies should be implemented based on clinical presentation and available resources.

Healthcare providers should ensure that they are prepared to provide supportive care and monitor the patient closely for any signs of toxicity.

Nonclinical Toxicology

No teratogenic or non-teratogenic effects have been reported in the available nonclinical studies. Additionally, there is no information regarding animal pharmacology and toxicology. The absence of data limits the ability to draw conclusions regarding the potential toxicological profile of the substance in nonclinical settings.

Postmarketing Experience

Postmarketing experience has revealed reports of several adverse reactions associated with the use of the product. These include nervousness, dizziness, sleeplessness, rash, and persistent headache. Such reactions have been documented through voluntary reports and surveillance programs, indicating that they may occur in patients using the product.

Patient Counseling

Patients should be advised to seek immediate medical assistance or contact a Poison Control Center at 1-800-222-1222 in the event of an overdose. It is important to emphasize that patients must not exceed the recommended dosage.

Healthcare providers should encourage patients to consult with a doctor prior to use if they have any of the following conditions: heart disease, high blood pressure, diabetes, thyroid issues, difficulty urinating due to an enlarged prostate gland, a cough that produces excessive phlegm, or a chronic cough associated with smoking, asthma, chronic bronchitis, or emphysema.

Patients should also be instructed to speak with a doctor or pharmacist before using this product if they are currently taking any other oral nasal decongestants or stimulants.

Healthcare providers must inform patients to discontinue use and consult a doctor if they experience nervousness, dizziness, or sleeplessness. Additionally, if symptoms do not improve within 7 days or are accompanied by fever, or if a cough persists for more than 7 days, recurs, or is accompanied by fever, rash, or a persistent headache, patients should seek medical advice, as these may indicate a serious condition.

It is crucial to advise patients against using this product if they are currently taking a prescription monoamine oxidase inhibitor (MAOI) or have taken one within the last two weeks. Patients should be encouraged to verify with their doctor or pharmacist if they are uncertain whether their prescription medication contains an MAOI.

Storage and Handling

The product is supplied in various package configurations, with specific NDC numbers available for identification. It is essential to store the product at a temperature range of 20-25°C (68°-77°F). Refrigeration is not recommended, as it may compromise the integrity of the product. Proper handling and storage conditions must be adhered to in order to maintain the product's efficacy and safety.

Additional Clinical Information

The medication is administered orally, with a recommended dosage of 10 mL every 4 hours for adults and children aged 12 years and older. Patients should not exceed 6 doses within a 24-hour period.

Clinicians should counsel patients to consult a healthcare professional if they are pregnant or breastfeeding before use. It is essential to keep the medication out of reach of children. In the event of an overdose, patients are advised to seek medical assistance or contact a Poison Control Center immediately at 1-800-222-1222.

Drug Information (PDF)

This file contains official product information for Tussin Multi Symptom Cold Cf, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Data Generation & Sources

This page was automatically generated and is maintained by the AllDrugs AI Data-Science Team. It was built from the FDA Structured Product Label (DailyMed) for Tussin Multi Symptom Cold Cf, retrieved by a validated AI data-extraction workflow.

All FDA-listed dosage forms and strengths are shown in the Packaging & NDC Codes section above. Regulatory status appears in the Summary Information panel above and was verified in the FDA National Drug Code directory and the NSDE NDC Directory daily file.

Note: an automated daemon monitors NSDE checksums; when the record for this NDC changes, the new file is pulled instantly and this page is refreshed.

No human clinician has reviewed this version.

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Orange Book data shown on this page are limited to Regulatory Status (Rx), Established Pharmacologic Class (EPC), and Mechanism of Action (MoA).

Regulatory data notice: Information on this page is reproduced verbatim from FDA public databases (NSDE, Orange Book, Purple Book, DailyMed SPL). NDA/ANDA drugs are FDA-approved, BLA biologics are FDA-licensed. Inclusion alone does not guarantee current market availability or imply FDA endorsement.

Medical disclaimer: This AI-generated content is provided for educational purposes only and does not constitute medical advice. Always consult a licensed healthcare professional for diagnosis or treatment decisions.