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Dover Aminofen, Dover Aminophen, Medi First Plus Non-Aspirin, Medi-First Non-...

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Active ingredient
Acetaminophen 325 mg
Other brand names
Dosage form
Tablet, Coated
Route
Oral
Prescription status
OTC (over the counter)
Marketed in the U.S.
Since 2008
Label revision date
September 8, 2025
Active ingredient
Acetaminophen 325 mg
Other brand names
Dosage form
Tablet, Coated
Route
Oral
Prescription status
OTC (over the counter)
CSA schedule
Not a scheduled drug
Marketed in the U.S.
Since 2008
Label revision date
September 8, 2025
Manufacturer
Unifirst First Aid Corporation
Registration number
M013
NDC roots
47682-057, 47682-058, 47682-059, 47682-060, 47682-145, 47682-303, 47682-803, 47682-903

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Drug Overview

Medique Apap is a non-aspirin pain reliever and fever reducer that contains acetaminophen (a common medication used to alleviate pain and reduce fever) in a dosage of 325 mg per tablet. It is designed to temporarily relieve minor aches and pains associated with headaches, muscular aches, minor arthritis pain, backaches, toothaches, and menstrual cramps, as well as to reduce fever.

This medication is suitable for households without young children and comes in a package containing 500 tablets, organized in tamper-evident unit dose packets for safety and convenience.

Uses

You can use this medication to temporarily relieve minor aches and pains caused by various conditions, including headaches, muscular aches, minor arthritis pain, backaches, toothaches, and cramps related to menstruation or premenstrual syndrome. It can also help ease discomfort from the common cold.

In addition to pain relief, this medication is effective in temporarily reducing fever, helping you feel more comfortable when you're not feeling well.

Dosage and Administration

If you are an adult or a child aged 12 years and older, you can take 2 tablets every 4 to 6 hours as needed while you have symptoms. However, make sure not to exceed 10 tablets in a 24-hour period unless your doctor advises otherwise. It's also important to limit your use to no more than 10 days unless directed by a healthcare professional.

For children under 12 years old, it's best to consult a doctor before giving them this medication. Always follow your healthcare provider's instructions to ensure safe and effective use.

What to Avoid

It's important to be cautious when using this medication. You should not take it if you are allergic to acetaminophen or any of the inactive ingredients in the product. Additionally, avoid using it alongside any other medications that contain acetaminophen, whether they are prescription or over-the-counter. If you're unsure whether a medication contains acetaminophen, please consult your doctor or pharmacist for guidance.

Remember, taking this medication improperly can lead to serious health issues, including dependence (a condition where your body becomes reliant on a substance). Always follow these guidelines to ensure your safety and well-being.

Side Effects

Taking this product may lead to some serious side effects, particularly related to your liver. It's important to avoid exceeding 4,000 mg of acetaminophen in a 24-hour period, taking it with other medications that also contain acetaminophen, or consuming three or more alcoholic drinks daily while using this product, as these can increase the risk of severe liver damage.

You should also be aware of potential allergic reactions, which can manifest as severe skin issues, including redness, blisters, or rashes. If you experience any of these symptoms, stop using the product immediately and seek medical help. Additionally, if you have liver disease or are taking blood thinners like warfarin, consult your doctor or pharmacist before using this medication. If your pain or fever worsens or lasts longer than expected, or if you notice new symptoms, it's important to stop using the product and consult a healthcare professional. In case of an overdose, seek medical assistance right away, even if you don't notice any symptoms.

Warnings and Precautions

This product contains acetaminophen, which can lead to severe liver damage if you exceed 4,000 mg in 24 hours, take it with other acetaminophen-containing medications, or consume three or more alcoholic drinks daily while using it. Additionally, be aware that acetaminophen may cause serious skin reactions, such as skin reddening, blisters, or rashes. If you experience any of these symptoms, stop using the product and seek medical help immediately.

Before using this medication, consult your doctor if you have liver disease or are taking the blood-thinning medication warfarin. If you suspect an overdose, it’s crucial to get emergency medical help or contact a Poison Control Center at 1-800-222-1222, even if you don’t notice any symptoms.

You should also stop taking this product and call your doctor if your pain worsens or lasts more than 10 days, if your fever worsens or lasts more than 3 days, if you develop new symptoms, or if you notice redness or swelling, as these could indicate a serious condition.

Overdose

If you suspect an overdose, it’s important to seek medical help immediately. You can contact a Poison Control Center at 1-800-222-1222 for guidance. Quick action is crucial for both adults and children, even if you don’t see any signs or symptoms of an overdose.

Signs of an overdose can vary, but they may include unusual drowsiness, confusion, or difficulty breathing. If you notice any of these symptoms or have concerns about a possible overdose, don’t hesitate to get help right away. Your safety and health are the top priority.

Pregnancy Use

If you are pregnant or breastfeeding, it’s important to consult with a healthcare professional before using this medication. They can provide guidance on whether it’s safe for you and your baby. Always prioritize your health and the health of your child by seeking expert advice.

Lactation Use

If you are pregnant or breastfeeding, it’s important to consult with a healthcare professional before using any medication. This ensures that you understand any potential risks and can make informed decisions about your health and the health of your baby. Always prioritize open communication with your doctor regarding your breastfeeding journey.

Pediatric Use

If you are considering this medication for your child, it's important to consult a doctor if your child is under 12 years old. For those aged 12 and older, the recommended dosage is 2 tablets every 4 to 6 hours as needed, but be sure not to exceed 10 tablets in a 24-hour period unless directed by a healthcare professional. Additionally, do not use this medication for more than 10 days without a doctor's guidance.

Be aware that an overdose can be serious, so seek immediate medical help for both adults and children, even if there are no noticeable symptoms. Always prioritize safety and follow the recommended guidelines.

Geriatric Use

If you are an older adult or a caregiver, it's important to be cautious when using certain medications. Before starting any new medication, make sure to consult with your doctor if you have liver disease, as this can affect how your body processes the drug. Additionally, if you are taking warfarin, a common blood thinner, it's essential to talk to your doctor or pharmacist to avoid any potential interactions.

In case of an overdose, seek medical help immediately, even if you don't notice any symptoms. Quick action is crucial for your safety and well-being. Always prioritize open communication with your healthcare provider to ensure the best care.

Renal Impairment

If you have kidney problems, it's important to know that the drug insert does not provide specific information about dosage adjustments, special monitoring, or safety considerations for your condition. This means that there are no tailored guidelines for how this medication may affect you if your kidneys are not functioning properly.

Always consult your healthcare provider for personalized advice and to discuss any concerns regarding your kidney health and medication use. They can help ensure that you receive the safest and most effective treatment based on your individual needs.

Hepatic Impairment

If you have liver problems, it's important to be cautious when using products that contain acetaminophen. Taking more than 4,000 mg in a 24-hour period can lead to severe liver damage, which is the maximum daily amount recommended. Additionally, you should avoid using other medications that also contain acetaminophen and limit alcohol consumption to fewer than three drinks per day while using this product.

Before starting any medication containing acetaminophen, please consult your doctor, especially if you have liver disease. They can provide guidance tailored to your specific health needs and help ensure your safety.

Drug Interactions

It's important to be aware that if you take acetaminophen, it can increase the effects of warfarin, a medication that helps prevent blood clots. This means there could be a higher risk of bleeding, so your healthcare provider may want to monitor your INR (a blood test that measures how long it takes your blood to clot) more closely if you are using these medications together.

Always discuss any medications you are taking with your healthcare provider, including over-the-counter drugs like acetaminophen. They can help ensure that your treatment is safe and effective, especially if you are on blood thinners like warfarin.

Storage and Handling

To ensure the safety and effectiveness of your product, store it at room temperature, ideally between 59°F and 86°F (15°C and 30°C). It's important to keep the product in its tamper-evident sealed packets, which help ensure that the contents remain uncontaminated. If you notice any packets that are opened or torn, do not use them, as this could compromise the safety and quality of the product.

By following these simple storage and handling guidelines, you can help maintain the integrity of the product and ensure its safe use.

Additional Information

No further information is available.

FAQ

What is Medique Apap?

Medique Apap is a non-aspirin pain reliever and fever reducer that contains 325 mg of acetaminophen.

What conditions does Medique Apap temporarily relieve?

It temporarily relieves minor aches and pains due to headache, muscular aches, minor arthritis pain, backache, the common cold, toothache, and premenstrual and menstrual cramps.

How should adults and children over 12 take Medique Apap?

Adults and children 12 years and over should take 2 tablets every 4 to 6 hours while symptoms last, not exceeding 10 tablets in 24 hours unless directed by a doctor.

What should I do if I have liver disease?

You should ask a doctor before using Medique Apap if you have liver disease.

Can I use Medique Apap with other acetaminophen-containing drugs?

No, do not use Medique Apap with any other drug containing acetaminophen, as this can lead to severe liver damage.

What are the signs of a severe skin reaction to acetaminophen?

Signs may include skin reddening, blisters, or rash. If you experience these symptoms, stop use and seek medical help immediately.

What should I do in case of an overdose?

In case of overdose, get medical help or contact a Poison Control Center right away, as quick medical attention is critical.

Is it safe to use Medique Apap during pregnancy or breastfeeding?

If you are pregnant or breastfeeding, ask a health professional before use.

How should I store Medique Apap?

Store Medique Apap at room temperature between 59°-86°F (15°-30°C) and use tamper-evident sealed packets.

Packaging Info

Below are the non-prescription pack sizes of Dover Aminofen, Dover Aminophen, Medi First Plus Non-Aspirin, Medi-First Non-Aspirin, Medi-First Plus Non-Aspirin, Medique Apap (acetaminophen). Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Dover Aminofen, Dover Aminophen, Medi First Plus Non-Aspirin, Medi-First Non-Aspirin, Medi-First Plus Non-Aspirin, Medique Apap.
Details

Drug Information (PDF)

This file contains official product information for Dover Aminofen, Dover Aminophen, Medi First Plus Non-Aspirin, Medi-First Non-Aspirin, Medi-First Plus Non-Aspirin, Medique Apap, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Description

No description information is available for the specified drug.

Uses and Indications

This drug is indicated for the temporary relief of minor aches and pains associated with various conditions, including headache, muscular aches, minor arthritis pain, backache, the common cold, toothache, and premenstrual and menstrual cramps. Additionally, it is indicated for the temporary reduction of fever.

There are no teratogenic or nonteratogenic effects associated with this drug.

Dosage and Administration

Adults and children aged 12 years and over are instructed to take 2 tablets every 4 to 6 hours as needed while symptoms persist. The maximum dosage should not exceed 10 tablets within a 24-hour period, unless otherwise directed by a healthcare professional. Additionally, the use of this medication should not extend beyond 10 days unless specifically advised by a doctor.

For children under 12 years of age, it is recommended to consult a healthcare professional for appropriate dosing guidance.

Contraindications

Use of this product is contraindicated in the following situations:

Patients should not use this product in conjunction with any other medication containing acetaminophen, whether prescription or nonprescription, due to the risk of acetaminophen overdose. If there is uncertainty regarding the presence of acetaminophen in other medications, consultation with a healthcare professional is advised.

Additionally, this product is contraindicated in individuals with a known allergy to acetaminophen or any of the inactive ingredients contained in the formulation, as this may lead to severe allergic reactions.

Warnings and Precautions

This product contains acetaminophen, which carries a significant risk of severe liver damage if not used according to the guidelines. Healthcare professionals should advise patients that the maximum daily dosage should not exceed 4,000 mg within a 24-hour period. Caution is particularly warranted if patients are concurrently using other medications that contain acetaminophen or if they consume three or more alcoholic beverages daily while taking this product.

Patients should be informed of the potential for severe skin reactions associated with acetaminophen use. Symptoms indicative of such reactions may include skin reddening, blisters, and rash. In the event of any skin reaction, patients must be instructed to discontinue use immediately and seek medical assistance.

Before initiating treatment, it is essential for patients to consult with a healthcare provider if they have a history of liver disease. Additionally, patients taking the anticoagulant warfarin should seek advice from a doctor or pharmacist prior to use, as interactions may occur.

In cases of overdose, immediate medical attention is critical. Patients should be advised to contact a Poison Control Center at 1-800-222-1222 or seek emergency medical help without delay, regardless of the presence of symptoms.

Patients should also be instructed to discontinue use and consult a healthcare professional if any of the following occur: worsening pain that persists for more than 10 days, a fever that worsens or lasts longer than 3 days, the emergence of new symptoms, or the presence of redness or swelling. These signs may indicate a serious underlying condition that requires further evaluation.

Side Effects

Severe adverse reactions associated with this product include the potential for severe liver damage, particularly in patients who exceed the maximum daily dosage of 4,000 mg of acetaminophen, use other medications containing acetaminophen concurrently, or consume three or more alcoholic drinks daily while using this product.

Patients should be aware of the risk of severe skin reactions, which may manifest as skin reddening, blisters, or rash. In the event of any skin reaction, it is imperative to discontinue use immediately and seek medical assistance.

This product should not be used in conjunction with any other drug containing acetaminophen, whether prescription or nonprescription. Patients with known allergies to acetaminophen or any inactive ingredients in this formulation should also refrain from use.

Prior to using this product, patients with liver disease should consult a healthcare professional. Additionally, individuals taking the anticoagulant warfarin should seek advice from a doctor or pharmacist before use.

Patients are advised to discontinue use and consult a healthcare provider if pain worsens or persists for more than 10 days, if fever worsens or lasts longer than 3 days, if new symptoms arise, or if redness or swelling occurs, as these may indicate a serious condition.

In cases of overdose, immediate medical attention is crucial. Patients should contact a Poison Control Center or seek medical help right away, even if no signs or symptoms are apparent, as prompt intervention is essential for both adults and children.

Drug Interactions

Acetaminophen has been observed to enhance the anticoagulant effect of warfarin, which may lead to an increased risk of bleeding. It is recommended that the International Normalized Ratio (INR) be monitored closely in patients who are receiving both acetaminophen and warfarin concurrently to ensure safe and effective management of anticoagulation therapy.

No additional drug interactions or interactions with laboratory tests have been reported.

Packaging & NDC

Below are the non-prescription pack sizes of Dover Aminofen, Dover Aminophen, Medi First Plus Non-Aspirin, Medi-First Non-Aspirin, Medi-First Plus Non-Aspirin, Medique Apap (acetaminophen). Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Dover Aminofen, Dover Aminophen, Medi First Plus Non-Aspirin, Medi-First Non-Aspirin, Medi-First Plus Non-Aspirin, Medique Apap.
Details

Pediatric Use

Pediatric patients under 12 years of age should consult a healthcare professional before use. For adolescents aged 12 years and older, the recommended dosage is 2 tablets every 4 to 6 hours as needed, with a maximum of 10 tablets in a 24-hour period, unless otherwise directed by a physician. It is advised not to exceed a duration of 10 days of use without medical guidance.

Healthcare providers should be aware of the overdose warning, which emphasizes the importance of seeking immediate medical attention for both adults and children, even in the absence of noticeable signs or symptoms.

Geriatric Use

Elderly patients should consult a healthcare provider prior to use if they have liver disease, as this may affect the metabolism and clearance of the medication. Additionally, it is important for geriatric patients to seek advice from a doctor or pharmacist if they are concurrently taking the anticoagulant warfarin, due to potential interactions that could increase the risk of bleeding.

In the event of an overdose, prompt medical attention is crucial for elderly patients, even if no signs or symptoms are immediately apparent. Monitoring for adverse effects and ensuring appropriate dosage adjustments may be necessary to enhance safety in this population.

Pregnancy

Pregnant patients and those who are breastfeeding should consult a healthcare professional prior to using this medication. The potential risks and benefits must be carefully considered in these populations to ensure the safety of both the mother and the fetus or infant.

Lactation

Lactating mothers are advised to consult a health professional prior to using this medication. There is no specific data available regarding the excretion of this medication in breast milk or its effects on breastfed infants. Therefore, caution is recommended when administering this medication to lactating individuals.

Renal Impairment

Patients with renal impairment have no specific information regarding dosage adjustments, special monitoring, or safety considerations provided in the drug insert. Therefore, healthcare professionals should exercise caution when prescribing this medication to individuals with reduced kidney function, as the lack of data necessitates careful clinical judgment.

Hepatic Impairment

Patients with hepatic impairment should exercise caution when using this product, as it contains acetaminophen, which is associated with the risk of severe liver damage. It is critical for patients to adhere to the following guidelines to minimize the risk of hepatotoxicity:

  • The maximum recommended daily dose of acetaminophen is 4,000 mg. Patients with compromised liver function should not exceed this limit, as exceeding it may lead to severe liver damage.

  • Patients should avoid concomitant use of other medications that contain acetaminophen, as this can increase the risk of exceeding the maximum daily dose and subsequently lead to liver injury.

  • Consumption of three or more alcoholic drinks per day while using this product is contraindicated, as alcohol can exacerbate the risk of liver damage.

Patients with a history of liver disease are advised to consult a healthcare professional prior to using this product to ensure safe use and appropriate monitoring of liver function.

Overdosage

In the event of an overdose, it is imperative to seek immediate medical assistance or contact a Poison Control Center at 1-800-222-1222. Prompt medical intervention is crucial for both adults and children, even in the absence of noticeable signs or symptoms.

Healthcare professionals should be aware that the lack of immediate symptoms does not preclude the potential for serious adverse effects. Therefore, vigilance and timely action are essential in managing overdose situations effectively.

Nonclinical Toxicology

No information is available regarding teratogenic effects. Additionally, there is no information provided concerning non-teratogenic effects. The insert does not contain any details related to nonclinical toxicology. Furthermore, there is no information available regarding animal pharmacology and toxicology.

Postmarketing Experience

Postmarketing experience has identified that acetaminophen may be associated with severe skin reactions. Reports indicate that symptoms can include skin reddening, blisters, and rash. In the event of a skin reaction, it is advised to discontinue use immediately and seek medical assistance.

Patient Counseling

Healthcare providers should advise patients to keep the medication out of reach of children to prevent accidental ingestion.

In the event of an overdose, it is crucial for patients to seek medical help immediately or contact a Poison Control Center at 1-800-222-1222. Providers should emphasize that prompt medical attention is essential for both adults and children, even if no signs or symptoms of overdose are apparent.

Patients who are pregnant or breastfeeding should be encouraged to consult with a healthcare professional before using the medication to ensure safety for themselves and their child.

Storage and Handling

The product is supplied in tamper-evident sealed packets to ensure integrity and safety. It is essential to store the packets at room temperature, specifically within the range of 59°F to 86°F (15°C to 30°C). Care should be taken to avoid using any packets that are opened or torn, as this may compromise the product's quality and efficacy.

Additional Clinical Information

No further data are available.

Drug Information (PDF)

This file contains official product information for Dover Aminofen, Dover Aminophen, Medi First Plus Non-Aspirin, Medi-First Non-Aspirin, Medi-First Plus Non-Aspirin, Medique Apap, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Data Generation & Sources

This page was automatically generated and is maintained by the AllDrugs AI Data-Science Team. It was built from the FDA Structured Product Label (DailyMed) for Dover Aminofen, Dover Aminophen, Medi First Plus Non-Aspirin, Medi-First Non-Aspirin, Medi-First Plus Non-Aspirin, Medique Apap, retrieved by a validated AI data-extraction workflow.

All FDA-listed dosage forms and strengths are shown in the Packaging & NDC Codes section above. Regulatory status appears in the Summary Information panel above and was verified in the FDA National Drug Code directory and the NSDE NDC Directory daily file.

Note: an automated daemon monitors NSDE checksums; when the record for this NDC changes, the new file is pulled instantly and this page is refreshed.

No human clinician has reviewed this version.

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Orange Book data shown on this page are limited to Regulatory Status (Rx), Established Pharmacologic Class (EPC), and Mechanism of Action (MoA).

Regulatory data notice: Information on this page is reproduced verbatim from FDA public databases (NSDE, Orange Book, Purple Book, DailyMed SPL). NDA/ANDA drugs are FDA-approved, BLA biologics are FDA-licensed. Inclusion alone does not guarantee current market availability or imply FDA endorsement.

Medical disclaimer: This AI-generated content is provided for educational purposes only and does not constitute medical advice. Always consult a licensed healthcare professional for diagnosis or treatment decisions.