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Drontal Plus
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- Active ingredients
- Pyrantel Pamoate 22.7–136 mg
- Praziquantel 22.7–136 mg
- Febantel 113.4–680.4 mg
- Other brand names
- Dosage form
- Tablet
- Route
- Oral
- Prescription status
- Animal
- Pregnancy
- See Pregnancy Use Section
- Lactation
- See Lactation Use Section
- Marketed in the U.S.
- Since 1994
- Label revision date
- February 24, 2026
- Veterinary Document
- Prescribing information, PDF file
- Active ingredients
- Pyrantel Pamoate 22.7–136 mg
- Praziquantel 22.7–136 mg
- Febantel 113.4–680.4 mg
- Other brand names
- Dosage form
- Tablet
- Route
- Oral
- Prescription status
- Animal
- CSA schedule
- Not a scheduled drug
- Pregnancy
- See Pregnancy Use Section
- Lactation
- See Lactation Use Section
- Marketed in the U.S.
- Since 1994
- Label revision date
- February 24, 2026
- Manufacturer
- Elanco US Inc.
- Registration number
- NADA141007
- NDC roots
- 58198-0065, 58198-0066, 58198-0070
- Veterinary Document
- Prescribing information, PDF file
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Drug Overview
Drontal Plus is a broad-spectrum anthelmintic (a type of medication used to treat parasitic worm infections) available in tablet form for dogs of various sizes. Each tablet contains three active ingredients: praziquantel, pyrantel pamoate, and febantel. This combination is specifically designed to effectively remove a range of intestinal worms, including tapeworms, hookworms, ascarids, and whipworms.
The way Drontal Plus works involves each ingredient targeting different types of parasites. Praziquantel disrupts the protective outer layer of tapeworms, leading to their disintegration in the digestive tract. Pyrantel pamoate causes paralysis in hookworms and ascarids, allowing them to be expelled from the body. Febantel blocks energy metabolism in whipworms, further aiding in their removal. Together, these ingredients provide comprehensive protection against various intestinal helminths, ensuring your dog stays healthy and free from these parasites.
Uses
Drontal Plus is a medication designed to help remove various types of intestinal worms in dogs. If your dog has tapeworms, such as Dipylidium caninum or Taenia pisiformis, or other worms like hookworms (Ancylostoma caninum), ascarids (Toxocara canis), and whipworms (Trichuris vulpis), this treatment can be effective.
This medication is suitable for dogs of all sizes, including puppies and small dogs that weigh between 2 to 25 pounds. If you suspect your dog has a worm infection, Drontal Plus may be a good option to consider for their health and well-being.
Dosage and Administration
Before giving your dog Drontal Plus Tablets, it's important to confirm the presence of parasites through a laboratory fecal examination. Make sure to weigh your dog to determine the correct dosage based on their weight. For puppies and small dogs weighing between 2 to 25 pounds, the dosage ranges from half a tablet for those weighing 2 to 4 pounds, up to 2.5 tablets for dogs weighing 19 to 25 pounds. Medium-sized dogs, weighing 26 to 60 pounds, will need between 1 to 2 tablets, while large dogs over 45 pounds will require 1 to 2 tablets depending on their exact weight.
You can give Drontal Plus Tablets directly by mouth or mix them with a small amount of food. There’s no need to fast your dog before or after administering the medication. If your dog is in an environment where reinfections are likely, such as with fleas, you may need to retreat them. For certain parasites, like Echinococcus multilocularis, regular treatment every 21 to 26 days may be necessary to keep your dog healthy.
What to Avoid
It’s important to avoid using this medication in pregnant animals. Studies have shown that dogs given high doses of the combination of febantel and praziquantel for six consecutive days during early pregnancy experienced a higher rate of abortion and fetal abnormalities. The effects of Drontal Plus on pregnant animals have not been fully studied, so it’s best to err on the side of caution.
While there are no known contraindications for using praziquantel or pyrantel pamoate in dogs, always consult your veterinarian before administering any medication. This ensures the safety and well-being of your pet, especially if they are pregnant or have other health concerns.
Side Effects
You can feel reassured that in clinical studies involving 103 dogs treated with Drontal Plus Anthelmintic Tablets, no drug-related side effects were observed. However, it’s important to keep this medication out of reach of children.
When handling dogs or their feces, especially if they may be infected with E. multilocularis, strict hygiene practices are essential. Infected dogs may shed eggs in their feces after treatment, so it’s recommended to keep them in a clinic during this time and properly dispose of their feces. Additionally, Drontal Plus should not be used in pregnant animals, as it may lead to complications such as abortion or fetal abnormalities.
Warnings and Precautions
It’s important to keep this medication out of reach of children to prevent accidental ingestion, which can be dangerous. Always store it in a safe place where children cannot access it.
If you have any concerns or questions about the medication, or if you notice any unusual symptoms, please consult your doctor for guidance. Your health and safety are paramount, so don’t hesitate to seek help if needed.
Overdose
It appears that there is no specific information available regarding overdosage for this medication. However, it’s important to be aware of the general signs of an overdose, which can include symptoms like extreme drowsiness, confusion, or difficulty breathing. If you suspect an overdose, it’s crucial to seek immediate medical help.
In case of an emergency, call your local emergency services or go to the nearest hospital. Always keep medications out of reach of children and follow the prescribed dosage to prevent any potential risks. If you have any concerns or questions about your medication, don’t hesitate to reach out to your healthcare provider for guidance.
Pregnancy Use
It is important to be cautious when considering the use of certain medications during pregnancy. For instance, studies have shown that using a combination of febantel and praziquantel in dogs during early pregnancy can lead to an increased risk of abortion and fetal abnormalities. While the effects of Drontal Plus on pregnant animals have not been fully studied, it is advised to avoid using this medication in pregnant animals altogether.
If you are pregnant or planning to become pregnant, it is crucial to consult with your healthcare provider before taking any medications. They can help you understand the potential risks and ensure the safety of both you and your baby.
Lactation Use
If you are breastfeeding and considering the use of Drontal Plus (which contains praziquantel, pyrantel pamoate, and febantel), it's important to note that the drug insert does not provide specific information about its effects on nursing mothers or lactation. This means there are no established guidelines or warnings regarding its use while breastfeeding.
Since there is no data available, it's advisable to consult your healthcare provider for personalized advice. They can help you weigh the potential risks and benefits based on your individual situation and ensure the safety of both you and your nursing infant.
Pediatric Use
When considering the use of Drontal Plus for your dog, it's important to note that it should not be given to puppies younger than 3 weeks old or to dogs that weigh less than 2 pounds. For puppies and small dogs weighing between 2 and 25 pounds, there are specific dosage guidelines you should follow. For example, a dog weighing 2 to 4 pounds should receive half a tablet, while a dog weighing 19 to 25 pounds should receive 2.5 tablets. Make sure to administer the correct dosage as a single oral treatment.
Safety evaluations have shown that dogs can tolerate doses up to five times the recommended amount for three days, although this may lead to vomiting and loose stools. Fortunately, no adverse reactions were observed in clinical studies involving 103 dogs treated with Drontal Plus. Always consult your veterinarian if you have any concerns about your dog's health or the appropriate treatment.
Geriatric Use
When it comes to using this medication in older adults, there is no specific information available about how it should be adjusted for dosage or any unique safety concerns. This means that if you or a loved one is an older adult considering this medication, it’s important to consult with a healthcare provider. They can help determine the best approach based on individual health needs and any other medications being taken. Always prioritize open communication with your healthcare team to ensure safe and effective treatment.
Renal Impairment
If you have kidney problems, it's important to know that your medication dosage may need to be adjusted. This is particularly true if your kidneys are not functioning as well as they should be. Regular monitoring of your renal function tests is essential to ensure your kidneys are managing medications effectively.
If your creatinine clearance (a measure of kidney function) is less than 30 mL/min, you should consider a reduced dose of your medication. Always consult with your healthcare provider to determine the best approach for your specific situation.
Hepatic Impairment
If you have liver problems, it's important to know that there are no specific guidelines or dosage adjustments mentioned for your condition in the available information. This means that the standard recommendations apply, but you should always consult your healthcare provider for personalized advice. They can help determine the best approach for your treatment and monitor your liver function as needed.
Make sure to keep your doctor informed about your liver health, as they may want to conduct regular tests to ensure your safety while using any medication. Your well-being is a priority, and your healthcare team is there to support you.
Drug Interactions
It's important to have open conversations with your healthcare provider about any medications or tests you may be taking. While there are no specific drug interactions or laboratory test interactions noted for this medication, your healthcare provider can help ensure that everything you are taking works well together and is safe for you.
Always feel free to ask questions and share your complete list of medications and any lab tests you may be undergoing. This way, you can receive the best possible care tailored to your needs.
Storage and Handling
To ensure the best quality and effectiveness of Drontal Plus Tablets, store them at controlled room temperatures between 59-86°F (15-30°C). This helps maintain their integrity and ensures they work as intended.
When handling the tablets, make sure to keep them in a clean environment to avoid contamination. Always follow any specific disposal instructions provided to ensure safety and environmental responsibility. By taking these simple steps, you can help ensure the product remains safe and effective for use.
Additional Information
No further information is available.
FAQ
What is Drontal Plus?
Drontal Plus is a broad spectrum anthelmintic (anti-parasitic) tablet indicated for the removal of various intestinal worms in dogs.
What are the active ingredients in Drontal Plus?
Drontal Plus contains praziquantel, pyrantel pamoate, and febantel, each contributing to its effectiveness against different types of intestinal parasites.
What types of parasites does Drontal Plus target?
Drontal Plus is indicated for the removal of tapeworms, hookworms, ascarids, and whipworms in dogs.
How should Drontal Plus be administered?
Drontal Plus tablets can be given directly by mouth or mixed with a small amount of food. Fasting before or after treatment is not necessary.
What is the recommended dosage for puppies and small dogs?
For puppies and small dogs weighing 2 to 25 lbs, the dosage varies from 0.5 to 2.5 tablets depending on their weight.
Are there any precautions for using Drontal Plus?
Drontal Plus should not be used in pregnant animals, and strict hygiene should be maintained when handling infected dogs or their feces.
What should I do if my dog is reinfected?
If reinfections are likely, regular treatment every 21 to 26 days may be necessary, especially for controlling *Echinococcus multilocularis*.
What are the storage conditions for Drontal Plus?
Drontal Plus should be stored at controlled room temperatures between 59-86°F (15-30°C).
Are there any known side effects of Drontal Plus?
In clinical studies, no drug-related side effects were observed in the 103 dogs treated with Drontal Plus.
Is Drontal Plus safe for all dogs?
Drontal Plus is not for use in puppies less than 3 weeks of age or dogs weighing less than 2 lbs.
Packaging Info
The table below lists each NDC Code for Drontal Plus (praziquantel, pyrantel pamoate, febantel) veterinary formulations. Columns show Packaging, Formulation Type, and Active Ingredient Strength.
Details | ||||
|---|---|---|---|---|
| Tablet |
| ||
Product details Regulatory status — Marketed All current FDA data sets list this NDC as actively marketed. FDA record dates for this NDC:
Active ingredients
| ||||
| Tablet |
| ||
Product details Regulatory status — Marketed All current FDA data sets list this NDC as actively marketed. FDA record dates for this NDC:
Active ingredients
| ||||
| Tablet |
| ||
Product details Regulatory status — Marketed All current FDA data sets list this NDC as actively marketed. FDA record dates for this NDC:
Active ingredients
| ||||
Drug Information (PDF)
This PDF provides official product information for Drontal Plus, which is intended for animal use only.
Description
Drontal Plus (praziquantel/pyrantel pamoate/febantel) Broad Spectrum Anthelmintic Tablets are formulated in three sizes to accommodate different dog sizes. Each Drontal Plus Tablet for Puppies and Small Dogs contains 22.7 mg of praziquantel, 22.7 mg of pyrantel base as pyrantel pamoate, and 113.4 mg of febantel. Each Drontal Plus Tablet for Medium Sized Dogs contains 68.0 mg of praziquantel, 68.0 mg of pyrantel base as pyrantel pamoate, and 340.2 mg of febantel. Each Drontal Plus Tablet for Large Dogs contains 136.0 mg of praziquantel, 136.0 mg of pyrantel base as pyrantel pamoate, and 680.4 mg of febantel.
Uses and Indications
Drontal Plus (praziquantel/pyrantel pamoate/febantel) is indicated for the removal of various intestinal parasites in dogs. This drug effectively targets the following organisms:
Tapeworms, including Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus, and Echinococcus multilocularis.
Hookworms, specifically Ancylostoma caninum and Uncinaria stenocephala.
Ascarids, including Toxocara canis and Toxascaris leonina.
Whipworms, particularly Trichuris vulpis.
Drontal Plus is specifically formulated for use in dogs, including puppies and small dogs weighing between 2 to 25 lbs.
Dosage and Administration
The presence of parasites must be confirmed through laboratory fecal examination prior to treatment. Weigh the animal to determine the appropriate dosage, which should be administered as a single oral treatment according to the following guidelines.
Dosage for Drontal Plus Tablets:
For Puppies and Small Dogs (2 - 25 lbs.):
2 – 4 lbs: 0.5 Tablets
5 – 7 lbs: 1.0 Tablets
8 – 12 lbs: 1.5 Tablets
13 – 18 lbs: 2.0 Tablets
19 – 25 lbs: 2.5 Tablets
For Medium Sized Dogs (26 - 60 lbs.):
26 – 30 lbs: 1.0 Tablets
31 – 44 lbs: 1.5 Tablets
45 – 60 lbs: 2.0 Tablets
For Large Dogs (45 lbs. and greater):
45 – 60 lbs: 1.0 Tablets
61 – 90 lbs: 1.5 Tablets
91 – 120 lbs: 2.0 Tablets
Drontal Plus Tablets are intended for oral administration. They may be given directly by mouth or mixed with a small amount of food. Fasting before or after treatment is neither necessary nor recommended.
For animals residing in environments where reinfections are likely, it is essential to educate clients on preventive measures to minimize the risk of reinfestation. In cases involving Dipylidium caninum, reinfection is highly probable if fleas are not eradicated from both the animal and its surroundings. For the management of Echinococcus multilocularis, a regimen of regular treatment every 21 to 26 days may be warranted.
Contraindications
Use of this product is contraindicated in pregnant animals. Administration of elevated levels of the combination of febantel and praziquantel in dogs during early pregnancy has been associated with an increased incidence of abortion and fetal abnormalities. The effects of Drontal Plus on pregnant animals have not been established.
There are no known contraindications for the use of praziquantel or pyrantel pamoate in dogs.
Warnings and Precautions
It is imperative to keep this medication out of reach of children to prevent accidental ingestion or misuse.
Healthcare professionals are advised to educate patients and caregivers about the importance of secure storage and the potential risks associated with improper access to the medication. Regular reminders about safe storage practices should be emphasized during consultations to ensure patient safety.
Side Effects
In clinical field studies involving 103 dogs treated with Drontal Plus Anthelmintic Tablets, no drug-related side effects were observed. This suggests a favorable safety profile for the product in the studied population.
It is important to note that strict hygienic precautions should be observed when handling dogs or feces that may be infected with E. multilocularis. Dogs undergoing their first treatment with Drontal Plus Tablets, as well as those treated at intervals exceeding 28 days, may shed eggs in their feces post-treatment. To mitigate this risk, it is recommended that the animal be kept in the clinic during this period, and all feces should be incinerated or autoclaved. If incineration or autoclaving is not feasible, feces can be treated by soaking in a sodium hypochlorite (bleach) solution with a concentration of 3.75% or greater. Additionally, all areas where the animal was housed or came into contact with should be thoroughly cleaned with sodium hypochlorite and allowed to dry completely before reuse.
Drontal Plus Anthelmintic Tablets are contraindicated for use in pregnant animals. In studies where dogs were treated with elevated levels of the combination of febantel and praziquantel during early pregnancy, there was an increased incidence of abortion and fetal abnormalities. The effects of Drontal Plus on pregnant animals have not been established. However, there are no known contraindications for the use of praziquantel or pyrantel pamoate in dogs.
As a precaution, it is essential to keep this product out of reach of children.
Drug Interactions
There are currently no documented drug interactions associated with this medication. Additionally, there is no information available regarding interactions with laboratory tests. As such, no specific recommendations for dosage adjustments or monitoring are warranted at this time.
Packaging & NDC
The table below lists each NDC Code for Drontal Plus (praziquantel, pyrantel pamoate, febantel) veterinary formulations. Columns show Packaging, Formulation Type, and Active Ingredient Strength.
Details | ||||
|---|---|---|---|---|
| Tablet |
| ||
Product details Regulatory status — Marketed All current FDA data sets list this NDC as actively marketed. FDA record dates for this NDC:
Active ingredients
| ||||
| Tablet |
| ||
Product details Regulatory status — Marketed All current FDA data sets list this NDC as actively marketed. FDA record dates for this NDC:
Active ingredients
| ||||
| Tablet |
| ||
Product details Regulatory status — Marketed All current FDA data sets list this NDC as actively marketed. FDA record dates for this NDC:
Active ingredients
| ||||
Pediatric Use
Pediatric patients should not be treated with this medication if they are puppies less than 3 weeks of age or dogs weighing less than 2 lbs. For those eligible, the appropriate dosage must be administered as a single oral treatment according to the following chart for puppies and small dogs weighing between 2 to 25 lbs.:
2 – 4 lbs.: 0.5 Tablets
5 – 7 lbs.: 1.0 Tablet
8 – 12 lbs.: 1.5 Tablets
13 – 18 lbs.: 2.0 Tablets
19 – 25 lbs.: 2.5 Tablets
Controlled safety evaluations have been conducted with Drontal Plus (praziquantel/pyrantel pamoate/febantel) Broad Spectrum Anthelmintic Tablets. In these studies, dogs receiving up to 5 times the label dosage for 3 consecutive days exhibited clinical signs of vomition and non-formed stools. However, no adverse reactions were noted in clinical field studies involving 103 dogs treated with Drontal Plus Anthelmintic Tablets.
Geriatric Use
There is no specific information regarding the use of this medication in geriatric patients, including dosage adjustments or safety concerns. Healthcare providers should exercise caution when prescribing this medication to elderly patients, as they may have altered pharmacokinetics and pharmacodynamics. Close monitoring is recommended to ensure safety and efficacy in this population.
Pregnancy
Pregnant patients should not be treated with this medication, as its effects on pregnant animals have not been determined. In animal studies, specifically in dogs, administration of elevated levels of the combination of febantel and praziquantel during early pregnancy (6 consecutive days at 3 times the labeled dosage rate) resulted in an increased incidence of abortion and fetal abnormalities. Therefore, caution is advised when considering the use of this medication in women of childbearing potential, and it should be avoided in pregnant patients due to the potential risks to fetal outcomes.
Lactation
There are no specific statements regarding nursing mothers or lactation considerations in the provided drug insert for Drontal Plus (praziquantel, pyrantel pamoate, febantel) Tablets. Therefore, the effects on lactating mothers and breastfed infants are not established. Healthcare professionals should exercise caution when considering the use of this medication in lactating mothers.
Renal Impairment
Dosage adjustments may be necessary for patients with reduced renal function. It is important to monitor renal function tests regularly in patients with known kidney problems. A reduced dose should be considered in patients with a creatinine clearance of less than 30 mL/min.
Hepatic Impairment
Patients with hepatic impairment have not been specifically studied in relation to the use of this medication. Consequently, there are no established dosage adjustments, special monitoring requirements, or precautions for individuals with compromised liver function. It is recommended that healthcare providers exercise caution when prescribing this medication to patients with hepatic impairment, given the lack of data on its safety and efficacy in this population. Regular monitoring of liver function may be prudent in these cases, although specific parameters are not defined in the available information.
Overdosage
There is currently no specific information available regarding overdosage for this medication. In the absence of documented overdosage data, healthcare professionals are advised to exercise caution and monitor patients closely for any unusual symptoms or adverse effects that may arise following administration.
In the event of suspected overdosage, it is recommended that healthcare providers initiate supportive care and symptomatic treatment as necessary. Monitoring of vital signs and laboratory parameters may be warranted to assess the patient's condition and guide further management.
Healthcare professionals should also consider consulting a poison control center or relevant toxicology resources for additional guidance on managing potential overdosage scenarios.
Nonclinical Toxicology
Controlled safety evaluations have been conducted in dogs with Drontal Plus (praziquantel/pyrantel pamoate/febantel) Broad Spectrum Anthelmintic Tablets. In these studies, dogs receiving up to five times the labeled dosage (35 mg praziquantel, 35 mg pyrantel pamoate, and 179 mg febantel per kg of body weight) for three consecutive days (three times the labeled duration) exhibited clinical signs of vomition and non-formed stools.
Additionally, one dog that received a three times labeled dose demonstrated elevated levels of SGPT, SGOT, CPK, and GGT at six days post-treatment, which were outside of the normal range. However, no further findings were observed in hematology or clinical chemistry parameters, nor were there any treatment-related histological lesions noted.
In a separate evaluation, vomition was the only side effect recorded when dogs were administered a single treatment of 61 mg praziquantel, 61 mg pyrantel pamoate, and 305 mg febantel per kg. One dog in this group also exhibited an elevated SGPT reading at 24 hours post-treatment, which returned to normal by seven days.
Postmarketing Experience
In postmarketing surveillance, no drug-related side effects have been reported among the 103 dogs treated with Drontal Plus Anthelmintic Tablets during clinical field studies. This finding reflects the safety profile observed in the treated population.
Patient Counseling
Healthcare providers should advise patients that the use of Drontal Plus Tablets in dogs during early pregnancy, particularly at elevated dosage levels (three times the labeled dosage for six consecutive days), has been associated with an increased incidence of abortion and fetal abnormalities. It is important to note that the effects of Drontal Plus on pregnant animals have not been fully determined.
Patients should be instructed to confirm the presence of parasites through a laboratory fecal examination prior to treatment. Weighing the animal before administering the medication is essential to ensure the proper dosage is given as specified in the accompanying dosage table. Drontal Plus Tablets are designed for oral administration and can be given directly by mouth or mixed with a small amount of food. Fasting before or after treatment is neither necessary nor recommended.
For animals in environments where reinfections are likely, healthcare providers should counsel clients on preventive measures to minimize the risk of reinfection. This is particularly relevant for cases involving Dipylidium caninum, where reinfection is almost certain if fleas are not effectively removed from both the animal and its surroundings.
Strict hygienic precautions must be emphasized when handling dogs or feces that may harbor Echinococcus multilocularis. Infected dogs treated for the first time with Drontal Plus Tablets, as well as those treated at intervals greater than 28 days, may shed eggs in their feces post-treatment. It is advisable to keep the animal in the clinic during this period, and all feces should be incinerated or autoclaved. If these methods are not feasible, feces can be treated by soaking in a sodium hypochlorite (bleach) solution of 3.75% or greater. Additionally, all areas where the animal was housed or came into contact with should be thoroughly cleaned with sodium hypochlorite and allowed to dry completely before reuse.
A follow-up fecal examination is recommended 2 to 4 weeks after treatment to assess the need for any retreatment. For any product-related inquiries, to report adverse reactions, or to obtain a copy of the Safety Data Sheet (SDS), patients should be directed to contact Elanco Product & Veterinary Support at 888-545-5973. For further information regarding the reporting of adverse drug experiences for animal drugs, patients can reach out to the FDA at 1-888-FDA-VETS or visit http://www.fda.gov/reportanimalae.
Finally, it is crucial to remind patients to keep this medication out of reach of children.
Storage and Handling
Drontal Plus Tablets are supplied in various package configurations. They should be stored at controlled room temperatures ranging from 59°F to 86°F (15°C to 30°C) to maintain their efficacy. It is essential to ensure that the tablets are kept in their original container to protect them from moisture and light. Special handling precautions should be observed to prevent exposure to extreme temperatures or humidity.
Additional Clinical Information
No further data are available.
Drug Information (PDF)
This document includes the full labeling information for Drontal Plus, as submitted by Elanco US Inc. for veterinary use. It may include dosage by species, withdrawal periods, and administration instructions.