Thiazide Diuretic Drug Class: Comprehensive Overview & Safety Insights

Most recent label update in this list Jan 9, 2026checked dailysee data sync status

Medications in the thiazide diuretic drug class. This comprehensive list includes all drugs in this therapeutic class, with safety warnings, side effects, and clinical guidance. Both patient‑friendly and professional‑level information is provided. The list is refreshed weekly and ordered by current user interest. Always consult a healthcare professional before starting or changing treatment.

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Drug safety and usage table for patients and healthcare providers. The numeric badges in each row show how many warnings, pregnancy/lactation notes, and side‑effects are listed inside the expandable details panel.
		Warnings	Pregnancy lactation	Side effects	Trend
Hydrochlorothiazide Rx tablet Aurobindo Pharma Limited	Popularity – score 100 out of 100 (most-viewed drug)	19 warnings	3 pregnancy and lactation warnings	47 side effects	Trend: was flat over the year; peak in May.
Hydrochlorothiazide® · First marketed 2007 · Label last revised June 26, 2024View full label details → Warnings Please use this medication with caution if you have severe renal disease. If you have impaired hepatic function or progressive liver disease, thiazides should be used carefully. Sensitivity reactions may occur, even if you do not have a history of allergy or bronchial asthma. There have been reports of exacerbation or activation of systemic lupus erythematosus. You generally should not take lithium with diuretics. Hydrochlorothiazide can cause an unusual reaction, leading to acute transient myopia and acute angle-closure glaucoma. If you have untreated acute angle-closure glaucoma, it can result in permanent vision loss. If you are taking hydrochlorothiazide, please protect your skin from the sun and have regular skin cancer screenings. Hypokalemia may develop, especially with brisk diuresis, in cases of severe cirrhosis or after prolonged therapy. Hypokalemia can lead to cardiac arrhythmia and may also increase the heart's sensitivity to the toxic effects of digitalis. Dilutional hyponatremia may occur in patients with edema during hot weather. Hyperuricemia may occur, or acute gout may be triggered in certain patients taking thiazides. If you are diabetic, you may need to adjust your dosage of insulin or oral hypoglycemic agents. If you notice progressive renal impairment, your healthcare provider may consider withholding or discontinuing diuretic therapy. Thiazides may reduce urinary calcium excretion. You may experience increases in cholesterol and triglyceride levels while on thiazide diuretic therapy. There are no adequate and well-controlled studies in pregnant women; this medication should only be used during pregnancy if clearly necessary. There is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Due to the potential for serious adverse reactions in nursing infants, you should discuss with your healthcare provider whether to continue nursing or to stop taking hydrochlorothiazide. Pregnancy & Lactation You should decide whether to continue nursing or to stop taking hydrochlorothiazide, considering how important the medication is for you. This medication should only be used during pregnancy if it is clearly necessary. Be aware that there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Side Effects You may experience weakness. You might have hypotension, including orthostatic hypotension, which can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. There is a possibility of developing pancreatitis. You could experience jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea may occur. You might feel nauseous and experience vomiting. Sialadenitis is a potential side effect. Cramping may happen. You could experience constipation. Gastric irritation is possible. Nausea may be a concern. You might experience a loss of appetite (anorexia). Aplastic anemia is a potential risk. Agranulocytosis could occur. You may experience leukopenia. There is a risk of hemolytic anemia. Thrombocytopenia may develop. Anaphylactic reactions are a serious possibility. You could experience necrotizing angiitis, which includes vasculitis and cutaneous vasculitis. Respiratory distress, including pneumonitis and pulmonary edema, may occur. Photosensitivity is a potential side effect. You might experience fever. Urticaria could develop. A rash may occur. Purpura is a possible side effect. You may experience an electrolyte imbalance. Hyperglycemia could occur. Glycosuria is a potential risk. You might experience hyperuricemia. Muscle spasms may happen. You could feel vertigo. Paresthesias may occur. Dizziness is a possible side effect. You might experience headaches. Restlessness could develop. There is a risk of renal failure. Renal dysfunction may occur. Interstitial nephritis is a potential concern. Erythema multiforme, including Stevens-Johnson syndrome, could develop. Exfoliative dermatitis, including toxic epidermal necrolysis, is a possibility. Alopecia may occur. You might experience transient blurred vision. Xanthopsia is a potential side effect. Impotence could develop. You have an increased risk of non-melanoma skin cancer. Acute transient myopia may occur. Acute angle-closure glaucoma is a risk, with symptoms including a sudden decrease in visual acuity or ocular pain. Warnings use with caution in severe renal disease thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma the possibility of exacerbation or activation of systemic lupus erythematosus has been reported lithium generally should not be given with diuretics hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma untreated acute angle-closure glaucoma can lead to permanent vision loss instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening hypokalemia may develop, especially with brisk diuresis, when severe cirrhosis is present or after prolonged therapy hypokalemia may cause cardiac arrhythmia and may also sensitize or exaggerate the response of the heart to the toxic effects of digitalis dilutional hyponatremia may occur in edematous patients in hot weather hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazides in diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required if progressive renal impairment becomes evident, consider withholding or discontinuing diuretic therapy thiazides may decrease urinary calcium excretion increases in cholesterol and triglyceride levels may be associated with thiazide diuretic therapy there are no adequate and well-controlled studies in pregnant women; this drug should be used during pregnancy only if clearly needed there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide Pregnancy & Lactation a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide, taking into account the importance of the drug to the mother this drug should be used during pregnancy only if clearly needed there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastric anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesias dizziness headache restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia impotence increased risk of non-melanoma skin cancer acute transient myopia acute angle-closure glaucoma (symptoms include acute onset of decreased visual acuity or ocular pain)
Hydrochlorothiazide Rx tablet ScieGen Pharmaceuticals, Inc.	Popularity – score 100 out of 100 (most-viewed drug)	23 warnings	3 pregnancy and lactation warnings	46 side effects	Trend: was flat over the year; peak in May.
Hydrochlorothiazide® · First marketed 2014 · Label last revised May 11, 2020View full label details → Warnings Please use this medication with caution if you have severe renal disease. If you have impaired hepatic function or progressive liver disease, thiazides should be used carefully. Sensitivity reactions may occur, even if you do not have a history of allergy or bronchial asthma. There have been reports of exacerbation or activation of systemic lupus erythematosus. You generally should not take lithium with diuretics. Your healthcare provider should monitor you for signs of fluid or electrolyte imbalance while you are on diuretic therapy. Be aware of warning signs or symptoms of fluid and electrolyte imbalance, which may include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting. Hypokalemia may develop, especially with brisk diuresis, in cases of severe cirrhosis, or after prolonged therapy. Inadequate oral electrolyte intake can also contribute to hypokalemia. Hypokalemia may lead to cardiac arrhythmia and can increase the heart's sensitivity to the toxic effects of digitalis. Dilutional hyponatremia may occur in patients with edema during hot weather. Hyperuricemia may develop, or acute gout may be triggered in certain patients taking thiazides. If you have diabetes, your healthcare provider may need to adjust your insulin or oral hypoglycemic agent dosages. Be aware that hyperglycemia may occur with thiazide diuretics. If you notice progressive renal impairment, consider discussing with your healthcare provider the possibility of withholding or discontinuing diuretic therapy. Thiazides have been shown to increase the urinary excretion of magnesium. Thiazides may reduce urinary calcium excretion. Marked hypercalcemia could indicate hidden hyperparathyroidism. Thiazides should be stopped before conducting tests for parathyroid function. There are no adequate and well-controlled studies in pregnant women; this medication should only be used during pregnancy if clearly necessary. Thiazides cross the placental barrier and can appear in cord blood; there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Thiazides are excreted in breast milk; you should decide whether to continue nursing or to discontinue hydrochlorothiazide. There are no well-controlled clinical trials involving pediatric patients. Pregnancy & Lactation You should decide whether to continue nursing or to stop taking hydrochlorothiazide, considering how important the medication is for you. This medication should only be used during pregnancy if it is clearly necessary. Be aware that there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Side Effects You may experience weakness. Hypotension, including orthostatic hypotension, may occur and can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. There is a risk of pancreatitis. You might develop jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea can occur. You may experience vomiting. Sialadenitis is a possible side effect. Cramping may happen. Constipation can occur. Gastric irritation is a potential issue. Nausea may be experienced. You might have a reduced appetite (anorexia). Aplastic anemia is a serious risk. Agranulocytosis may occur. Leukopenia is a possible side effect. You could experience hemolytic anemia. Thrombocytopenia may occur. Be aware of the possibility of anaphylactic reactions. Necrotizing angiitis, including vasculitis and cutaneous vasculitis, may develop. Respiratory distress, including pneumonitis and pulmonary edema, is a concern. Photosensitivity can occur. You may experience fever. Urticaria is a possible side effect. A rash may develop. Purpura can occur. Electrolyte imbalance is a potential risk. You might experience hyperglycemia. Glycosuria may occur. Hyperuricemia is a possible side effect. Muscle spasms can happen. You may experience vertigo. Paresthesias might occur. Dizziness can happen. Headaches may be experienced. Restlessness is a possible side effect. There is a risk of renal failure. Renal dysfunction may occur. Interstitial nephritis is a concern. Erythema multiforme, including Stevens-Johnson syndrome, may develop. Exfoliative dermatitis, including toxic epidermal necrolysis, is a potential risk. Alopecia may occur. You might experience transient blurred vision. Xanthopsia is a possible side effect. Impotence may occur. Acute transient myopia is a potential concern. Acute angle-closure glaucoma may develop. Warnings use with caution in severe renal disease thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma the possibility of exacerbation or activation of systemic lupus erythematosus has been reported lithium generally should not be given with diuretics all patients receiving diuretic therapy should be observed for evidence of fluid or electrolyte imbalance warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting hypokalemia may develop, especially with brisk diuresis, when severe cirrhosis is present or after prolonged therapy interference with adequate oral electrolyte intake will also contribute to hypokalemia hypokalemia may cause cardiac arrhythmia and may also sensitize or exaggerate the response of the heart to the toxic effects of digitalis dilutional hyponatremia may occur in edematous patients in hot weather hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazides in diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required hyperglycemia may occur with thiazide diuretics if progressive renal impairment becomes evident, consider withholding or discontinuing diuretic therapy thiazides have been shown to increase the urinary excretion of magnesium thiazides may decrease urinary calcium excretion marked hypercalcemia may be evidence of hidden hyperparathyroidism thiazides should be discontinued before carrying out tests for parathyroid function there are no adequate and well-controlled studies in pregnant women; this drug should be used during pregnancy only if clearly needed thiazides cross the placental barrier and appear in cord blood; there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults thiazides are excreted in breast milk; a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide there are no well-controlled clinical trials in pediatric patients Pregnancy & Lactation a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide, taking into account the importance of the drug to the mother this drug should be used during pregnancy only if clearly needed there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastic anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesias dizziness headache restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia impotence acute transient myopia acute angle-closure glaucoma
Hydrochlorothiazide Rx capsule REMEDYREPACK INC.	Popularity – score 100 out of 100 (most-viewed drug)	25 warnings	3 pregnancy and lactation warnings	45 side effects	Trend: was flat over the year; peak in May.
Hydrochlorothiazide® · First marketed 2020 · Label last revised July 8, 2025View full label details → Warnings Hydrochlorothiazide can cause an unusual reaction, leading to acute transient myopia and acute angle-closure glaucoma. Symptoms may include a sudden decrease in visual acuity or eye pain, typically occurring within hours to weeks after starting the medication. If left untreated, acute angle-closure glaucoma can result in permanent vision loss. The main course of action is to stop taking hydrochlorothiazide as quickly as possible. You may be at risk for developing acute angle-closure glaucoma if you have a history of sulfonamide or penicillin allergy. If you have latent diabetes mellitus, it may become apparent, and if you are diabetic and taking thiazides, you might need to adjust your insulin dose. Patients with impaired renal function may experience cumulative effects from thiazides. In these patients, thiazides could lead to azotemia. Your healthcare provider should periodically check your serum electrolytes if you are at risk for developing hypokalemia. You should be monitored for signs of fluid or electrolyte disturbances, such as hyponatremia, hypochloremic alkalosis, hypokalemia, and hypomagnesemia. Warning signs of fluid and electrolyte imbalance include dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pain or cramps, fatigue, low blood pressure, reduced urine output, rapid heartbeat, and gastrointestinal issues like nausea and vomiting. Hypokalemia may occur, especially with significant diuresis in the presence of severe cirrhosis, during the use of corticosteroids or adrenocorticotropic hormone (ACTH), or after prolonged treatment. Dilutional hyponatremia can be life-threatening and may happen in patients with edema during hot weather. Use thiazides cautiously if you have impaired liver function. They can trigger hepatic coma in individuals with severe liver disease. Thiazides reduce calcium excretion, and some patients on long-term thiazide therapy have shown pathological changes in the parathyroid glands, along with hypercalcemia and hypophosphatemia. If you are taking hydrochlorothiazide, be sure to protect your skin from the sun and have regular skin cancer screenings. Taking a non-steroidal anti-inflammatory agent can lessen the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing, and thiazide diuretics. You should stop taking thiazides before undergoing tests for parathyroid function. There are no adequate and well-controlled studies in pregnant women; this medication should only be used during pregnancy if absolutely necessary. Thiazides can cross the placental barrier and appear in cord blood. There is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Thiazides are present in breast milk; you should decide whether to continue nursing or to stop taking hydrochlorothiazide, considering how important the medication is for you. The safety and effectiveness of this medication in children have not been established. Elderly patients (i.e., over 65 years) may experience a greater reduction in blood pressure and an increase in side effects when taking hydrochlorothiazide. Pregnancy & Lactation You should use this drug during pregnancy only if it is clearly needed. Be aware that there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults. You and your healthcare provider should decide whether to discontinue nursing or to stop hydrochlorothiazide, considering how important the drug is for you. Side Effects You may experience weakness. You might have hypotension, including orthostatic hypotension, which can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. There is a possibility of developing pancreatitis. You could experience jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea may occur. You might feel nauseous and experience vomiting. Sialadenitis is another potential side effect. Cramping may happen. You could experience constipation. Gastric irritation is possible. Nausea may be a concern. You might experience a loss of appetite (anorexia). Aplastic anemia is a rare but serious side effect. Agranulocytosis could occur. You may experience leukopenia. There is a risk of hemolytic anemia. Thrombocytopenia is another potential side effect. Anaphylactic reactions are possible. You might develop necrotizing angiitis, which includes vasculitis and cutaneous vasculitis. Respiratory distress, including pneumonitis and pulmonary edema, may occur. Photosensitivity is a possibility. You might experience fever. Urticaria could develop. A rash may appear. Purpura is another potential side effect. You may experience an electrolyte imbalance. Hyperglycemia is a possibility. Glycosuria may occur. You might experience hyperuricemia. Muscle spasms could happen. You may feel vertigo. Paresthesia is a potential side effect. Dizziness may occur. You might experience headaches. Restlessness could be a concern. There is a risk of renal failure. Renal dysfunction may occur. Interstitial nephritis is a possibility. Erythema multiforme, including Stevens-Johnson syndrome, could develop. Exfoliative dermatitis, including toxic epidermal necrolysis, is a potential side effect. Alopecia may occur. You might experience transient blurred vision. Xanthopsia is a possibility. Impotence could happen. There is an increased risk of non-melanoma skin cancer. Warnings hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma symptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiation untreated acute angle-closure glaucoma can lead to permanent vision loss the primary treatment is to discontinue hydrochlorothiazide as rapidly as possible risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy latent diabetes mellitus may become manifest and diabetic patients given thiazides may require adjustment of their insulin dose cumulative effects of the thiazides may develop in patients with impaired renal function in such patients, thiazides may precipitate azotemia periodic determination of serum electrolytes should be performed in patients who may be at risk for the development of hypokalemia patients should be observed for signs of fluid or electrolyte disturbances, i.e., hyponatremia, hypochloremic alkalosis, and hypokalemia and hypomagnesemia warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting hypokalemia may develop, especially with brisk diuresis when severe cirrhosis is present, during concomitant use of corticosteroid or adrenocorticotropic hormone (ACTH) or after prolonged therapy dilutional hyponatremia is life-threatening and may occur in edematous patients in hot weather thiazides should be used with caution in patients with impaired hepatic function they can precipitate hepatic coma in patients with severe liver disease calcium excretion is decreased by thiazides, and pathologic changes in the parathyroid glands, with hypercalcemia and hypophosphatemia, have been observed in a few patients on prolonged thiazide therapy instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics thiazides should be discontinued before carrying out tests for parathyroid function there are no adequate and well-controlled studies in pregnant women; this drug should be used during pregnancy only if clearly needed thiazides cross the placental barrier and appear in cord blood there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults thiazides are excreted in breast milk; a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide, taking into account the importance of the drug to the mother safety and effectiveness in pediatric patients have not been established a greater blood pressure reduction and an increase in side effects may be observed in the elderly (i.e., > 65 years) with hydrochlorothiazide Pregnancy & Lactation this drug should be used during pregnancy only if clearly needed there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide, taking into account the importance of the drug to the mother Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastric anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesia dizziness headache restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia impotence increased risk of non-melanoma skin cancer
Hydrochlorothiazide Rx capsule Westminster Pharmaceuticals	Popularity – score 100 out of 100 (most-viewed drug)	28 warnings	3 pregnancy and lactation warnings	45 side effects	Trend: was flat over the year; peak in May.
Hydrochlorothiazide® · First marketed 2019 · Label last revised January 5, 2021View full label details → Warnings Hydrochlorothiazide can cause an unusual reaction, leading to acute transient myopia and acute angle-closure glaucoma. Symptoms may include a sudden decrease in visual acuity or eye pain, typically occurring within hours to weeks after starting the medication. If left untreated, acute angle-closure glaucoma can result in permanent vision loss. If you experience any symptoms, please discontinue hydrochlorothiazide as quickly as possible. You may be at risk for developing acute angle-closure glaucoma if you have a history of sulfonamide or penicillin allergy. If you have latent diabetes mellitus, it may become apparent, and if you are diabetic and taking thiazides, you might need to adjust your insulin dose. Patients with impaired renal function may experience cumulative effects from thiazides. Thiazides can lead to azotemia in individuals with impaired renal function. Your healthcare provider should periodically check your serum electrolytes if you are at risk for developing hypokalemia. You should be monitored for signs of fluid or electrolyte disturbances, such as hyponatremia, hypochloremic alkalosis, hypokalemia, and hypomagnesemia. Warning signs of fluid and electrolyte imbalance include dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pain or cramps, fatigue, low blood pressure, reduced urine output, rapid heartbeat, and gastrointestinal issues like nausea and vomiting. Hypokalemia may occur, especially with significant diuresis in the presence of severe cirrhosis, during the use of corticosteroids or adrenocorticotropic hormone (ACTH), or after prolonged treatment. Dilutional hyponatremia is a serious condition that can happen in patients with swelling during hot weather. Thiazides should be used cautiously if you have impaired liver function. In patients with severe liver disease, thiazides can trigger hepatic coma. Thiazides reduce calcium excretion, and some patients on long-term thiazide therapy have shown pathological changes in the parathyroid glands, along with hypercalcemia and hypophosphatemia. If you are taking hydrochlorothiazide, remember to protect your skin from the sun and schedule regular skin cancer screenings. When taken together, alcohol, barbiturates, or narcotics may increase the risk of orthostatic hypotension. You may need to adjust the dosage of your antidiabetic medication if you are taking it alongside thiazides. Cholestyramine and colestipol resins can bind to hydrochlorothiazide, reducing its absorption from the gastrointestinal tract by up to 85% and 43%, respectively. Corticosteroids or ACTH may lead to increased electrolyte depletion, particularly hypokalemia. Lithium should generally not be taken with diuretics, as these medications can lower the renal clearance of lithium and significantly raise the risk of lithium toxicity. Thiazides should be stopped before conducting tests for parathyroid function. There are no adequate and well-controlled studies in pregnant women; this medication should only be used during pregnancy if absolutely necessary. Thiazides can cross the placental barrier and appear in cord blood, posing a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions seen in adults. Thiazides are present in breast milk; you should decide whether to continue nursing or to stop hydrochlorothiazide, considering the importance of the medication for you. The safety and effectiveness of this medication in children have not been established. Elderly patients (those over 65 years) may experience a greater reduction in blood pressure and an increase in side effects when taking hydrochlorothiazide. Pregnancy & Lactation You should decide whether to continue nursing or to stop taking hydrochlorothiazide, considering how important the medication is for you. This medication should only be used during pregnancy if it is clearly necessary. Be aware that there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Side Effects You may experience weakness. You might have hypotension, including orthostatic hypotension, which can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. There is a possibility of developing pancreatitis. You could experience jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea may occur. You might feel nauseous and experience vomiting. Sialadenitis is a potential side effect. Cramping may happen. You could experience constipation. Gastric irritation is possible. Nausea may be a concern. You might experience a loss of appetite (anorexia). Aplastic anemia is a rare but serious side effect. Agranulocytosis could occur. You may experience leukopenia. There is a risk of hemolytic anemia. Thrombocytopenia may happen. Anaphylactic reactions are a serious concern. You might develop necrotizing angiitis, which includes vasculitis and cutaneous vasculitis. Respiratory distress, including pneumonitis and pulmonary edema, may occur. Photosensitivity is a potential side effect. You might experience fever. Urticaria could develop. A rash may occur. Purpura is a possible side effect. You may experience an electrolyte imbalance. Hyperglycemia could happen. Glycosuria is a potential concern. You might experience hyperuricemia. Muscle spasms may occur. You could feel vertigo. Paresthesia is a possible side effect. Dizziness may happen. You might experience headaches. Restlessness could occur. There is a risk of renal failure. Renal dysfunction may happen. Interstitial nephritis is a potential concern. Erythema multiforme, including Stevens-Johnson syndrome, could occur. Exfoliative dermatitis, including toxic epidermal necrolysis, is a possible side effect. Alopecia may happen. You might experience transient blurred vision. Xanthopsia is a potential side effect. Impotence could occur. There is an increased risk of non-melanoma skin cancer. Warnings hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma symptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiation untreated acute angle-closure glaucoma can lead to permanent vision loss discontinue hydrochlorothiazide as rapidly as possible if symptoms occur risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy latent diabetes mellitus may become manifest and diabetic patients given thiazides may require adjustment of their insulin dose cumulative effects of the thiazides may develop in patients with impaired renal function thiazides may precipitate azotemia in patients with impaired renal function periodic determination of serum electrolytes should be performed in patients who may be at risk for the development of hypokalemia patients should be observed for signs of fluid or electrolyte disturbances, i.e., hyponatremia, hypochloremic alkalosis, and hypokalemia and hypomagnesemia warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting hypokalemia may develop, especially with brisk diuresis when severe cirrhosis is present, during concomitant use of corticosteroid or adrenocorticotropic hormone (ACTH) or after prolonged therapy dilutional hyponatremia is life-threatening and may occur in edematous patients in hot weather thiazides should be used with caution in patients with impaired hepatic function thiazides can precipitate hepatic coma in patients with severe liver disease calcium excretion is decreased by thiazides, and pathologic changes in the parathyroid glands, with hypercalcemia and hypophosphatemia, have been observed in a few patients on prolonged thiazide therapy instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening when given concurrently, alcohol, barbiturates, or narcotics may cause potentiation of orthostatic hypotension dosage adjustment of the antidiabetic drug may be required when given concurrently with antidiabetic drugs cholestyramine and colestipol resins bind the hydrochlorothiazide and reduce its absorption from the gastrointestinal tract by up to 85 and 43 percent, respectively corticosteroid or ACTH may cause intensified electrolyte depletion, particularly hypokalemia lithium generally should not be given with diuretics as diuretic agents reduce the renal clearance of lithium and greatly increase the risk of lithium toxicity thiazides should be discontinued before carrying out tests for parathyroid function there are no adequate and well-controlled studies in pregnant women; this drug should be used during pregnancy only if clearly needed thiazides cross the placental barrier and appear in cord blood; there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults thiazides are excreted in breast milk; a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide, taking into account the importance of the drug to the mother safety and effectiveness in pediatric patients have not been established a greater blood pressure reduction and an increase in side effects may be observed in the elderly (i.e., > 65 years) with hydrochlorothiazide Pregnancy & Lactation a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide, taking into account the importance of the drug to the mother this drug should be used during pregnancy only if clearly needed there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastric anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesia dizziness headache restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia impotence increased risk of non-melanoma skin cancer
Hydrochlorothiazide Rx tablet REMEDYREPACK INC.	Popularity – score 100 out of 100 (most-viewed drug)	32 warnings	2 pregnancy and lactation warnings	46 side effects	Trend: was flat over the year; peak in May.
Hydrochlorothiazide® · First marketed 2023 · Label last revised May 7, 2025View full label details → Warnings Please use this medication with caution if you have severe renal disease. Thiazides may lead to azotemia if you have renal disease. If you have impaired renal function, be aware that cumulative effects of the drug may develop. Use thiazides carefully if you have impaired hepatic function or progressive liver disease. Minor changes in fluid and electrolyte balance could lead to hepatic coma. Sensitivity reactions may occur, even if you do not have a history of allergy or bronchial asthma. There have been reports of exacerbation or activation of systemic lupus erythematosus. Generally, lithium should not be taken with diuretics. Be aware that acute transient myopia and acute angle-closure glaucoma may occur. Symptoms to watch for include a sudden decrease in visual acuity or ocular pain. If left untreated, acute angle-closure glaucoma can result in permanent vision loss. Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. If you are receiving diuretic therapy, your healthcare provider should monitor you for signs of fluid or electrolyte imbalance. Warning signs of fluid and electrolyte imbalance include dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, low blood pressure, reduced urine output, rapid heartbeat, and gastrointestinal issues like nausea and vomiting. Hypokalemia may develop, especially with brisk diuresis, in cases of severe cirrhosis, or after prolonged therapy. Hypokalemia can lead to cardiac arrhythmia and may increase the heart's sensitivity to the toxic effects of digitalis. You can avoid or treat hypokalemia by using potassium-sparing diuretics or potassium supplements. Dilutional hyponatremia may occur in patients with edema during hot weather. Hyperuricemia or acute gout may be triggered in certain patients taking thiazides. If you have diabetes, your healthcare provider may need to adjust your insulin or oral hypoglycemic agent dosage. Hyperglycemia may occur while using thiazide diuretics. Latent diabetes mellitus may become apparent during thiazide therapy. If you notice progressive renal impairment, consider discussing with your healthcare provider the possibility of withholding or discontinuing diuretic therapy. Thiazides can increase the urinary excretion of magnesium, which may lead to hypomagnesemia. Thiazides may reduce urinary calcium excretion. Marked hypercalcemia could indicate hidden hyperparathyroidism. Thiazides should be stopped before conducting tests for parathyroid function. Taking a non-steroidal anti-inflammatory agent can diminish the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing, and thiazide diuretics. If you are using hydrochlorothiazide along with non-steroidal anti-inflammatory agents, your healthcare provider should closely observe you to ensure the desired effect of the diuretic is achieved. There are no adequate and well-controlled studies in pregnant women; this medication should only be used during pregnancy if clearly necessary. Thiazides can cross the placental barrier and appear in cord blood, posing risks of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Due to the potential for serious adverse reactions in nursing infants, you should decide whether to continue nursing or to discontinue hydrochlorothiazide. Pregnancy & Lactation You should use this drug during pregnancy only if it is clearly necessary. There is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Side Effects You may experience weakness. You might have hypotension, including orthostatic hypotension, which can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. There is a possibility of developing pancreatitis. You could experience jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea may occur. You might feel nauseous and experience vomiting. Sialadenitis is a potential side effect. Cramping may happen. You could experience constipation. Gastric irritation is possible. Nausea may be a concern. You might experience anorexia. Aplastic anemia is a serious side effect to be aware of. Agranulocytosis could occur. You may experience leukopenia. There is a risk of hemolytic anemia. Thrombocytopenia is another potential side effect. Be aware of the possibility of anaphylactic reactions. Necrotizing angiitis, including vasculitis and cutaneous vasculitis, may occur. You might experience respiratory distress, which can include pneumonitis and pulmonary edema. Photosensitivity is a potential side effect. Fever may occur. You could experience urticaria. A rash may develop. Purpura is a possible side effect. Electrolyte imbalance could happen. You might experience hyperglycemia. Glycosuria is a potential concern. Hyperuricemia may occur. Muscle spasms could happen. You might feel vertigo. Paresthesias may occur. Dizziness is a possible side effect. You might experience headaches. Restlessness could be a concern. There is a risk of renal failure. You may experience renal dysfunction. Interstitial nephritis is a potential side effect. Erythema multiforme, including Stevens-Johnson syndrome, may occur. Exfoliative dermatitis, including toxic epidermal necrolysis, is a possibility. Alopecia may happen. You might experience transient blurred vision. Xanthopsia is a potential side effect. Impotence could occur. Acute transient myopia may happen. Be aware of the risk of acute angle-closure glaucoma, which may present with sudden decreased visual acuity or ocular pain. Warnings use with caution in severe renal disease thiazides may precipitate azotemia in patients with renal disease cumulative effects of the drug may develop in patients with impaired renal function thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease minor alterations of fluid and electrolyte balance may precipitate hepatic coma sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma the possibility of exacerbation or activation of systemic lupus erythematosus has been reported lithium generally should not be given with diuretics acute transient myopia and acute angle-closure glaucoma may occur symptoms include acute onset of decreased visual acuity or ocular pain untreated acute angle-closure glaucoma can lead to permanent vision loss risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy all patients receiving diuretic therapy should be observed for evidence of fluid or electrolyte imbalance warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting hypokalemia may develop, especially with brisk diuresis, when severe cirrhosis is present or after prolonged therapy hypokalemia may cause cardiac arrhythmia and may also sensitize or exaggerate the response of the heart to the toxic effects of digitalis hypokalemia may be avoided or treated by use of potassium sparing diuretics or potassium supplements dilutional hyponatremia may occur in edematous patients in hot weather hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazides in diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required hyperglycemia may occur with thiazide diuretics latent diabetes mellitus may become manifest during thiazide therapy if progressive renal impairment becomes evident, consider withholding or discontinuing diuretic therapy thiazides have been shown to increase the urinary excretion of magnesium; this may result in hypomagnesemia thiazides may decrease urinary calcium excretion marked hypercalcemia may be evidence of hidden hyperparathyroidism thiazides should be discontinued before carrying out tests for parathyroid function the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic and antihypertensive effects of loop, potassium-sparing and thiazide diuretics when hydrochlorothiazide and non-steroidal anti-inflammatory agents are used concomitantly the patient should be observed closely to determine if the desired effect of the diuretic is obtained there are no adequate and well-controlled studies in pregnant women; this drug should be used during pregnancy only if clearly needed thiazides cross the placental barrier and appear in cord blood; there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide Pregnancy & Lactation this drug should be used during pregnancy only if clearly needed there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastric anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesias dizziness headache restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia impotence acute transient myopia acute angle-closure glaucoma (symptoms include acute onset of decreased visual acuity or ocular pain)
Hydrochlorothiazide Rx tablet Legacy Pharmaceutical Packaging, LLC	Popularity – score 100 out of 100 (most-viewed drug)	28 warnings	3 pregnancy and lactation warnings	32 side effects	Trend: was flat over the year; peak in May.
Hydrochlorothiazide® · First marketed 1973 · Label last revised March 19, 2025View full label details → Warnings Please use this medication with caution if you have severe renal disease. Thiazides may lead to azotemia if you have renal disease. If you have impaired renal function, be aware that cumulative effects of the drug may develop. Use thiazides carefully if you have impaired hepatic function or progressive liver disease. Minor changes in fluid and electrolyte balance could lead to hepatic coma. Sensitivity reactions may occur, even if you do not have a history of allergy or bronchial asthma. There have been reports of exacerbation or activation of systemic lupus erythematosus. Generally, lithium should not be taken with diuretics. If you are taking hydrochlorothiazide, remember to protect your skin from the sun and schedule regular skin cancer screenings. Your healthcare provider should monitor you for signs of fluid or electrolyte imbalance. Warning signs of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, low blood pressure, reduced urine output, rapid heartbeat, and gastrointestinal issues like nausea and vomiting. Hypokalemia may develop, especially with brisk diuresis, if you have severe cirrhosis or after prolonged therapy. Not getting enough oral electrolytes can contribute to hypokalemia. Hypokalemia may lead to cardiac arrhythmia and can increase the heart's sensitivity to the toxic effects of digitalis. Dilutional hyponatremia may occur in patients with edema during hot weather. Hyperuricemia may develop, or acute gout may be triggered in some patients taking thiazides. If you have diabetes, your healthcare provider may need to adjust your insulin or oral hypoglycemic agent dosages. Hyperglycemia can occur with thiazide diuretics. Thiazide therapy may reveal latent diabetes mellitus. If you notice progressive renal impairment, discuss with your healthcare provider whether to withhold or discontinue diuretic therapy. Thiazides can increase the urinary excretion of magnesium. Thiazides may reduce urinary calcium excretion. Marked hypercalcemia could indicate hidden hyperparathyroidism. Thiazides should be stopped before conducting tests for parathyroid function. There are no adequate and well-controlled studies in pregnant women; this drug should only be used during pregnancy if clearly necessary. Thiazides cross the placental barrier and can appear in cord blood; there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions. You should decide whether to stop nursing or to discontinue hydrochlorothiazide, considering the importance of the drug to you. There are no well-controlled clinical trials in pediatric patients. Pregnancy & Lactation You should decide whether to continue nursing or to stop taking hydrochlorothiazide, considering how important the medication is for you. This medication should only be used during pregnancy if it is clearly necessary. Be aware that there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Side Effects You may experience acute transient myopia. There is a risk of acute angle-closure glaucoma. You might notice decreased visual acuity. You could feel ocular pain. Be aware of potential fluid or electrolyte imbalance. You may develop hyponatremia. Hypochloremic alkalosis could occur. You might experience hypokalemia. Dryness of mouth may be a side effect. You could feel increased thirst. Weakness may occur. You might feel lethargic. Drowsiness could be a possibility. Restlessness may be experienced. You might feel confused. Seizures are a potential risk. Muscle pains or cramps may occur. You could experience muscular fatigue. Hypotension may be a concern. Oliguria could develop. Tachycardia may occur. You might experience gastrointestinal disturbances such as nausea. Vomiting could happen. Cardiac arrhythmia is a potential side effect. You may develop hyperuricemia. Acute gout could occur. You might experience hyperglycemia. There is a risk of latent diabetes mellitus. Hypomagnesemia may develop. You might see intermittent and slight elevation of serum calcium. Marked hypercalcemia could occur. You may notice increases in cholesterol and triglyceride levels. Warnings use with caution in severe renal disease thiazides may precipitate azotemia in patients with renal disease cumulative effects of the drug may develop in patients with impaired renal function thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease minor alterations of fluid and electrolyte balance may precipitate hepatic coma sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma the possibility of exacerbation or activation of systemic lupus erythematosus has been reported lithium generally should not be given with diuretics instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening all patients receiving diuretic therapy should be observed for evidence of fluid or electrolyte imbalance warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting hypokalemia may develop, especially with brisk diuresis, when severe cirrhosis is present or after prolonged therapy interference with adequate oral electrolyte intake will contribute to hypokalemia hypokalemia may cause cardiac arrhythmia and may also sensitize or exaggerate the response of the heart to the toxic effects of digitalis dilutional hyponatremia may occur in edematous patients in hot weather hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazides in diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required hyperglycemia may occur with thiazide diuretics latent diabetes mellitus may become manifest during thiazide therapy if progressive renal impairment becomes evident, consider withholding or discontinuing diuretic therapy thiazides have been shown to increase the urinary excretion of magnesium thiazides may decrease urinary calcium excretion marked hypercalcemia may be evidence of hidden hyperparathyroidism thiazides should be discontinued before carrying out tests for parathyroid function there are no adequate and well-controlled studies in pregnant women; this drug should be used during pregnancy only if clearly needed thiazides cross the placental barrier and appear in cord blood; there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide, taking into account the importance of the drug to the mother there are no well controlled clinical trials in pediatric patients Pregnancy & Lactation a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide, taking into account the importance of the drug to the mother this drug should be used during pregnancy only if clearly needed there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults Side Effects acute transient myopia acute angle-closure glaucoma decreased visual acuity ocular pain fluid or electrolyte imbalance hyponatremia hypochloremic alkalosis hypokalemia dryness of mouth thirst weakness lethargy drowsiness restlessness confusion seizures muscle pains or cramps muscular fatigue hypotension oliguria tachycardia gastrointestinal disturbances such as nausea vomiting cardiac arrhythmia hyperuricemia acute gout hyperglycemia latent diabetes mellitus hypomagnesemia intermittent and slight elevation of serum calcium marked hypercalcemia increases in cholesterol and triglyceride levels
Hydrochlorothiazide Rx tablet REMEDYREPACK INC.	Popularity – score 100 out of 100 (most-viewed drug)	27 warnings	2 pregnancy and lactation warnings	46 side effects	Trend: was flat over the year; peak in May.
Hydrochlorothiazide® · First marketed 2025 · Label last revised November 28, 2025View full label details → Warnings Please use this medication with caution if you have severe renal disease. Thiazides may lead to azotemia if you have renal disease. If you have impaired renal function, be aware that cumulative effects of the drug may develop. Use thiazides carefully if you have impaired hepatic function or progressive liver disease. Minor changes in fluid and electrolyte balance could lead to hepatic coma. Sensitivity reactions may occur, even if you do not have a history of allergy or bronchial asthma. There have been reports of exacerbation or activation of systemic lupus erythematosus. Hydrochlorothiazide can cause an unusual reaction, resulting in acute transient myopia and acute angle-closure glaucoma. Symptoms may include a sudden decrease in visual acuity or ocular pain, typically occurring within hours to weeks after starting the drug. If acute angle-closure glaucoma is left untreated, it can lead to permanent vision loss. Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. Your healthcare provider should monitor you for signs of fluid or electrolyte imbalance while you are on diuretic therapy. Warning signs of fluid and electrolyte imbalance include dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, low blood pressure, reduced urine output, rapid heartbeat, and gastrointestinal issues like nausea and vomiting. Hypokalemia may develop, especially with brisk diuresis, if you have severe cirrhosis or after prolonged therapy. Hypokalemia can lead to cardiac arrhythmia and may increase the heart's sensitivity to the toxic effects of digitalis. Hyperuricemia may occur, or acute gout may be triggered in some patients taking thiazides. If you have diabetes, your healthcare provider may need to adjust your insulin or oral hypoglycemic medication dosages. You may experience hyperglycemia while taking thiazide diuretics. Latent diabetes mellitus may become apparent during thiazide therapy. If you notice progressive renal impairment, consider discussing with your healthcare provider the possibility of withholding or stopping diuretic therapy. Thiazides can increase the urinary excretion of magnesium, which may lead to hypomagnesemia. Thiazides may reduce urinary calcium excretion. Marked hypercalcemia could indicate hidden hyperparathyroidism. Thiazides should be stopped before conducting tests for parathyroid function. There are no adequate and well-controlled studies in pregnant women; this medication should only be used during pregnancy if clearly necessary. Thiazides cross the placental barrier and can appear in cord blood; there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Due to the potential for serious adverse reactions in nursing infants, you should decide whether to continue nursing or to stop taking hydrochlorothiazide. Pregnancy & Lactation You should use this drug during pregnancy only if it is clearly needed. Be aware that there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults. Side Effects You may experience weakness. You might have hypotension, including orthostatic hypotension, which can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. There is a possibility of developing pancreatitis. You could experience jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea may occur. You might feel nauseous and experience vomiting. Sialadenitis is another potential side effect. Cramping may happen. You could experience constipation. Gastric irritation is possible. Nausea may be a concern. You might experience a loss of appetite (anorexia). Aplastic anemia is a serious side effect to be aware of. Agranulocytosis could occur. You may experience leukopenia. There is a risk of hemolytic anemia. Thrombocytopenia is another potential side effect. Be aware of the possibility of anaphylactic reactions. Necrotizing angiitis, including vasculitis and cutaneous vasculitis, may occur. You might experience respiratory distress, which can include pneumonitis and pulmonary edema. Photosensitivity is a potential side effect. Fever may occur. You could experience urticaria. A rash may develop. Purpura is another possible side effect. Electrolyte imbalances can happen. You might experience hyperglycemia. Glycosuria is a potential concern. Hyperuricemia may occur. Muscle spasms could happen. You might feel vertigo. Paresthesias may occur. Dizziness is a possible side effect. You might experience headaches. Restlessness could be a concern. There is a risk of renal failure. Renal dysfunction may occur. Interstitial nephritis is another potential side effect. Erythema multiforme, including Stevens-Johnson syndrome, may occur. Exfoliative dermatitis, including toxic epidermal necrolysis, is a possibility. Alopecia may happen. You might experience transient blurred vision. Xanthopsia is a potential side effect. Impotence could occur. Acute transient myopia may happen. Be aware of the risk of acute angle-closure glaucoma, which may present with sudden decreased visual acuity or ocular pain. Warnings use with caution in severe renal disease thiazides may precipitate azotemia in patients with renal disease cumulative effects of the drug may develop in patients with impaired renal function thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease minor alterations of fluid and electrolyte balance may precipitate hepatic coma sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma the possibility of exacerbation or activation of systemic lupus erythematosus has been reported hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma symptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiation untreated acute angle-closure glaucoma can lead to permanent vision loss risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy all patients receiving diuretic therapy should be observed for evidence of fluid or electrolyte imbalance warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting hypokalemia may develop, especially with brisk diuresis, when severe cirrhosis is present or after prolonged therapy hypokalemia may cause cardiac arrhythmia and may also sensitize or exaggerate the response of the heart to the toxic effects of digitalis hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazides in diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required hyperglycemia may occur with thiazide diuretics latent diabetes mellitus may become manifest during thiazide therapy if progressive renal impairment becomes evident, consider withholding or discontinuing diuretic therapy thiazides have been shown to increase the urinary excretion of magnesium; this may result in hypomagnesemia thiazides may decrease urinary calcium excretion marked hypercalcemia may be evidence of hidden hyperparathyroidism thiazides should be discontinued before carrying out tests for parathyroid function there are no adequate and well-controlled studies in pregnant women; this drug should be used during pregnancy only if clearly needed thiazides cross the placental barrier and appear in cord blood; there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide Pregnancy & Lactation this drug should be used during pregnancy only if clearly needed there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastric anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesias dizziness headache restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia impotence acute transient myopia acute angle-closure glaucoma (symptoms include acute onset of decreased visual acuity or ocular pain)
Hydrochlorothiazide Rx tablet REMEDYREPACK INC.	Popularity – score 100 out of 100 (most-viewed drug)	26 warnings	3 pregnancy and lactation warnings	46 side effects	Trend: was flat over the year; peak in May.
Hydrochlorothiazide® · First marketed 2023 · Label last revised July 29, 2025View full label details → Warnings Please use this medication with caution if you have severe renal disease. Thiazides may lead to azotemia if you have renal disease. If you have impaired renal function, be aware that cumulative effects of the drug may develop. Use thiazides carefully if you have impaired hepatic function or progressive liver disease. Minor changes in fluid and electrolyte balance could lead to hepatic coma. Sensitivity reactions may occur, even if you do not have a history of allergy or bronchial asthma. There have been reports of exacerbation or activation of systemic lupus erythematosus. Be aware that acute transient myopia and acute angle-closure glaucoma may occur. Symptoms to watch for include a sudden decrease in visual acuity or ocular pain. If acute angle-closure glaucoma is left untreated, it can result in permanent vision loss. Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. If you are receiving diuretic therapy, your healthcare provider should monitor you for signs of fluid or electrolyte imbalance. Warning signs of fluid and electrolyte imbalance include dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, low blood pressure, reduced urine output, rapid heartbeat, and gastrointestinal issues like nausea and vomiting. Hypokalemia may develop, especially with brisk diuresis, if you have severe cirrhosis or after prolonged therapy. Hypokalemia can lead to cardiac arrhythmia and may increase the heart's sensitivity to the toxic effects of digitalis. Hyperuricemia may occur, or acute gout may be triggered in some patients taking thiazides. If you have diabetes, your healthcare provider may need to adjust your insulin or oral hypoglycemic medication dosage. Be aware that hyperglycemia may occur with thiazide diuretics. Latent diabetes mellitus may become apparent during thiazide therapy. If you notice progressive renal impairment, consider discussing with your healthcare provider the possibility of withholding or discontinuing diuretic therapy. Thiazides can increase the urinary excretion of magnesium, which may lead to hypomagnesemia. Thiazides may reduce urinary calcium excretion. Marked hypercalcemia could indicate hidden hyperparathyroidism. Please discontinue thiazides before undergoing tests for parathyroid function. If you are taking hydrochlorothiazide, protect your skin from the sun and schedule regular skin cancer screenings. Thiazides are excreted in breast milk, so you should discuss with your healthcare provider whether to continue nursing or to stop taking hydrochlorothiazide. Pregnancy & Lactation You should decide whether to continue nursing or to stop taking hydrochlorothiazide, considering how important the medication is for you. This medication should only be used during pregnancy if it is clearly necessary. Be aware that there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Side Effects You may experience weakness. You might have hypotension, including orthostatic hypotension, which can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. There is a possibility of developing pancreatitis. You could experience jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea may occur. You might feel nauseous and experience vomiting. Sialadenitis is a potential side effect. Cramping may happen. You could experience constipation. Gastric irritation is possible. Nausea may be a concern. You might experience a loss of appetite (anorexia). Aplastic anemia is a rare but serious side effect. Agranulocytosis could occur. You may experience leukopenia. There is a risk of hemolytic anemia. Thrombocytopenia may happen. Anaphylactic reactions are a serious concern. You might develop necrotizing angiitis, which includes vasculitis and cutaneous vasculitis. Respiratory distress, including pneumonitis and pulmonary edema, may occur. Photosensitivity is a potential side effect. You might experience fever. Urticaria could develop. A rash may occur. Purpura is a possible side effect. You may experience an electrolyte imbalance. Hyperglycemia could happen. Glycosuria is a potential concern. You might experience hyperuricemia. Muscle spasms may occur. You could feel vertigo. Paresthesias might happen. Dizziness is a possible side effect. You may experience headaches. Restlessness could occur. There is a risk of renal failure. Renal dysfunction may happen. Interstitial nephritis is a potential concern. Erythema multiforme, including Stevens-Johnson Syndrome, could occur. Exfoliative dermatitis, including toxic epidermal necrolysis, is a possible side effect. Alopecia may happen. You might experience transient blurred vision. Xanthopsia is a potential side effect. Impotence could occur. There is an increased risk of non-melanoma skin cancer. You may have an increased risk for squamous cell carcinoma (SCC). Warnings use with caution in severe renal disease thiazides may precipitate azotemia in patients with renal disease cumulative effects of the drug may develop in patients with impaired renal function thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease minor alterations of fluid and electrolyte balance may precipitate hepatic coma sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma the possibility of exacerbation or activation of systemic lupus erythematosus has been reported acute transient myopia and acute angle-closure glaucoma may occur symptoms include acute onset of decreased visual acuity or ocular pain untreated acute angle-closure glaucoma can lead to permanent vision loss risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy all patients receiving diuretic therapy should be observed for evidence of fluid or electrolyte imbalance warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting hypokalemia may develop, especially with brisk diuresis, when severe cirrhosis is present or after prolonged therapy hypokalemia may cause cardiac arrhythmia and may also sensitize or exaggerate the response of the heart to the toxic effects of digitalis hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazides in diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required hyperglycemia may occur with thiazide diuretics latent diabetes mellitus may become manifest during thiazide therapy if progressive renal impairment becomes evident, consider withholding or discontinuing diuretic therapy thiazides have been shown to increase the urinary excretion of magnesium; this may result in hypomagnesemia thiazides may decrease urinary calcium excretion marked hypercalcemia may be evidence of hidden hyperparathyroidism thiazides should be discontinued before carrying out tests for parathyroid function instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening thiazides are excreted in breast milk; a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide Pregnancy & Lactation a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide, taking into account the importance of the drug to the mother this drug should be used during pregnancy only if clearly needed there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastric anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesias dizziness headache restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson Syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia impotence increased risk of non-melanoma skin cancer increased risk for squamous cell carcinoma (SCC)
Hydrochlorothiazide Rx tablet REMEDYREPACK INC.	Popularity – score 100 out of 100 (most-viewed drug)	33 warnings	2 pregnancy and lactation warnings	46 side effects	Trend: was flat over the year; peak in May.
Hydrochlorothiazide® · First marketed 2025 · Label last revised July 25, 2025View full label details → Warnings Please use this medication with caution if you have severe renal disease. Thiazides may lead to azotemia if you have renal disease. If you have impaired renal function, be aware that cumulative effects of the drug may develop. Use thiazides carefully if you have impaired hepatic function or progressive liver disease. Minor changes in fluid and electrolyte balance could lead to hepatic coma. Sensitivity reactions may occur, even if you do not have a history of allergy or bronchial asthma. There have been reports of exacerbation or activation of systemic lupus erythematosus. You may experience acute transient myopia and acute angle-closure glaucoma. Symptoms to watch for include a sudden decrease in visual acuity or ocular pain. If acute angle-closure glaucoma is left untreated, it can result in permanent vision loss. Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. If you are receiving diuretic therapy, your healthcare provider should monitor you for signs of fluid or electrolyte imbalance. Warning signs of fluid and electrolyte imbalance include dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, low blood pressure, reduced urine output, rapid heartbeat, and gastrointestinal issues like nausea and vomiting. Hypokalemia may develop, especially with brisk diuresis, in cases of severe cirrhosis or after prolonged therapy. Hypokalemia can lead to cardiac arrhythmia and may increase the heart's sensitivity to the toxic effects of digitalis. You can avoid or treat hypokalemia by using potassium-sparing diuretics or potassium supplements. In hot weather, dilutional hyponatremia may occur in patients with edema. The appropriate treatment for dilutional hyponatremia is to restrict water intake. Hyperuricemia may occur, or acute gout may be triggered in some patients taking thiazides. If you have diabetes, your healthcare provider may need to adjust your insulin or oral hypoglycemic medication dosages. Hyperglycemia can occur with thiazide diuretics. Thiazide therapy may reveal latent diabetes mellitus. If you notice progressive renal impairment, consider discussing with your healthcare provider the possibility of withholding or discontinuing diuretic therapy. Thiazides can increase the urinary excretion of magnesium. Thiazides may reduce urinary calcium excretion. Marked hypercalcemia could indicate hidden hyperparathyroidism. You should discontinue thiazides before undergoing tests for parathyroid function. Taking a non-steroidal anti-inflammatory agent can lessen the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing, and thiazide diuretics. Your healthcare provider should closely observe you to ensure the desired effect of the diuretic is achieved. There are no adequate and well-controlled studies involving pregnant women. This medication should only be used during pregnancy if it is clearly necessary. There is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Due to the potential for serious adverse reactions in nursing infants, you should decide whether to continue nursing or to stop taking hydrochlorothiazide. Pregnancy & Lactation You should use this drug during pregnancy only if it is clearly necessary. There is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Side Effects You may experience weakness. You might have hypotension, including orthostatic hypotension, which can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. Pancreatitis is a possible side effect. You could develop jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea may occur. You might experience vomiting. Sialadenitis is another potential side effect. Cramping can happen. You may experience constipation. Gastric irritation is possible. Nausea may occur. You might experience anorexia. Aplastic anemia is a potential risk. Agranulocytosis could occur. You may experience leukopenia. Hemolytic anemia is a possible side effect. Thrombocytopenia may occur. Be aware of the risk of anaphylactic reactions. Necrotizing angiitis, including vasculitis and cutaneous vasculitis, is a potential concern. You might experience respiratory distress, which can include pneumonitis and pulmonary edema. Photosensitivity may occur. Fever is a possible side effect. You might experience urticaria. A rash could develop. Purpura is another potential side effect. Electrolyte imbalance may occur. You might experience hyperglycemia. Glycosuria is a possible side effect. Hyperuricemia may occur. Muscle spasms can happen. You might experience vertigo. Paresthesias may occur. Dizziness is a possible side effect. You might experience headaches. Restlessness can happen. Be aware that renal failure is a potential risk. Renal dysfunction may occur. Interstitial nephritis is a possible concern. Erythema multiforme, including Stevens-Johnson syndrome, is a potential side effect. Exfoliative dermatitis, including toxic epidermal necrolysis, may occur. Alopecia is a possible side effect. You might experience transient blurred vision. Xanthopsia could occur. Impotence is a potential side effect. Acute transient myopia may happen. Be aware of the risk of acute angle-closure glaucoma. Warnings use with caution in severe renal disease thiazides may precipitate azotemia in patients with renal disease cumulative effects of the drug may develop in patients with impaired renal function thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease minor alterations of fluid and electrolyte balance may precipitate hepatic coma sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma the possibility of exacerbation or activation of systemic lupus erythematosus has been reported acute transient myopia and acute angle-closure glaucoma may occur symptoms include acute onset of decreased visual acuity or ocular pain untreated acute angle-closure glaucoma can lead to permanent vision loss risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy all patients receiving diuretic therapy should be observed for evidence of fluid or electrolyte imbalance warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting hypokalemia may develop, especially with brisk diuresis, when severe cirrhosis is present or after prolonged therapy hypokalemia may cause cardiac arrhythmia and may also sensitize or exaggerate the response of the heart to the toxic effects of digitalis hypokalemia may be avoided or treated by use of potassium sparing diuretics or potassium supplements dilutional hyponatremia may occur in edematous patients in hot weather appropriate therapy for dilutional hyponatremia is water restriction hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazides in diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required hyperglycemia may occur with thiazide diuretics latent diabetes mellitus may become manifest during thiazide therapy if progressive renal impairment becomes evident, consider withholding or discontinuing diuretic therapy thiazides have been shown to increase the urinary excretion of magnesium thiazides may decrease urinary calcium excretion marked hypercalcemia may be evidence of hidden hyperparathyroidism thiazides should be discontinued before carrying out tests for parathyroid function the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic and antihypertensive effects of loop, potassium-sparing and thiazide diuretics patients should be observed closely to determine if the desired effect of the diuretic is obtained there are no adequate and well-controlled studies in pregnant women this drug should be used during pregnancy only if clearly needed there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide Pregnancy & Lactation this drug should be used during pregnancy only if clearly needed there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastric anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesias dizziness headache restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia impotence acute transient myopia acute angle-closure glaucoma
Hydrochlorothiazide Rx tablet Unichem Pharmaceuticals (USA) , Inc.	Popularity – score 100 out of 100 (most-viewed drug)	32 warnings	3 pregnancy and lactation warnings	47 side effects	Trend: was flat over the year; peak in May.
Hydrochlorothiazide® · First marketed 2008 · Label last revised June 13, 2025View full label details → Warnings Please use this medication with caution if you have severe renal disease. Thiazides may lead to azotemia if you have renal disease. If you have impaired renal function, be aware that cumulative effects of the drug may develop. Use thiazides carefully if you have impaired hepatic function or progressive liver disease. Minor changes in fluid and electrolyte balance could lead to hepatic coma. Sensitivity reactions may occur, even if you do not have a history of allergy or bronchial asthma. There have been reports of exacerbation or activation of systemic lupus erythematosus. Hydrochlorothiazide can cause an unusual reaction, resulting in acute transient myopia and acute angle-closure glaucoma. Symptoms may include a sudden decrease in visual acuity or ocular pain, typically occurring within hours to weeks after starting the drug. If left untreated, acute angle-closure glaucoma can result in permanent vision loss. The best course of action is to stop taking hydrochlorothiazide as quickly as possible. If your intraocular pressure remains uncontrolled, prompt medical or surgical treatments may be necessary. Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. If you are receiving diuretic therapy, your healthcare provider should monitor you for signs of fluid or electrolyte imbalance. Warning signs of fluid and electrolyte imbalance include dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, low blood pressure, reduced urine output, rapid heartbeat, and gastrointestinal issues like nausea and vomiting. Hypokalemia may develop, especially with brisk diuresis, in cases of severe cirrhosis, or after prolonged therapy. Hypokalemia can lead to cardiac arrhythmia and may increase the heart's sensitivity to the toxic effects of digitalis. You can avoid or treat hypokalemia by using potassium-sparing diuretics or potassium supplements. Dilutional hyponatremia may occur in patients with edema during hot weather. The appropriate treatment is to restrict water intake, rather than adding salt, unless the hyponatremia is life-threatening. In cases of actual salt depletion, appropriate replacement is the best therapy. Hyperuricemia may occur, or acute gout may be triggered in some patients taking thiazides. If you have diabetes, your healthcare provider may need to adjust your insulin or oral hypoglycemic agent dosages. Hyperglycemia may occur while taking thiazide diuretics. Thiazide therapy may reveal latent diabetes mellitus. If you notice progressive renal impairment, consider discussing with your healthcare provider the possibility of withholding or stopping diuretic therapy. Thiazides can increase the urinary excretion of magnesium, which may lead to hypomagnesemia. Thiazides may reduce urinary calcium excretion. Marked hypercalcemia could indicate hidden hyperparathyroidism. You should stop taking thiazides before undergoing tests for parathyroid function. If you are taking hydrochlorothiazide, protect your skin from the sun and have regular skin cancer screenings. Thiazides are excreted in breast milk; you should discuss with your healthcare provider whether to continue nursing or to stop taking hydrochlorothiazide. Pregnancy & Lactation You should decide whether to continue nursing or to stop taking hydrochlorothiazide, considering how important the medication is for you. This medication should only be used during pregnancy if it is clearly necessary. Be aware that there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Side Effects You may experience weakness. You might have hypotension, including orthostatic hypotension, which can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. There is a possibility of developing pancreatitis. You could experience jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea may occur. You might feel nauseous and experience vomiting. Sialadenitis is a potential side effect. Cramping may happen. You could experience constipation. Gastric irritation is possible. Nausea may be a concern. You might experience anorexia. Aplastic anemia is a rare but serious side effect. Agranulocytosis could occur. You may experience leukopenia. There is a risk of hemolytic anemia. Thrombocytopenia is a potential side effect. Anaphylactic reactions are possible. You might develop necrotizing angiitis, which includes vasculitis and cutaneous vasculitis. Respiratory distress, including pneumonitis and pulmonary edema, may occur. You could experience photosensitivity. Fever may be a side effect. Urticaria could develop. You might notice a rash. Purpura is a potential side effect. Electrolyte imbalance may occur. You could experience hyperglycemia. Glycosuria is a possibility. Hyperuricemia may occur. Muscle spasms could happen. You might feel vertigo. Paresthesias may occur. Dizziness is a potential side effect. You might experience headaches. Restlessness could be a concern. There is a risk of renal failure. Renal dysfunction may occur. Interstitial nephritis is a potential side effect. Erythema multiforme, including Stevens-Johnson Syndrome, may occur. Exfoliative dermatitis, including toxic epidermal necrolysis, is a possibility. Alopecia may happen. You might experience transient blurred vision. Xanthopsia could occur. Impotence is a potential side effect. There is an increased risk of non-melanoma skin cancer. Acute transient myopia may occur. Acute angle-closure glaucoma is a possibility, with symptoms including a sudden decrease in visual acuity or ocular pain. Warnings use with caution in severe renal disease thiazides may precipitate azotemia in patients with renal disease cumulative effects of the drug may develop in patients with impaired renal function thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease minor alterations of fluid and electrolyte balance may precipitate hepatic coma sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma the possibility of exacerbation or activation of systemic lupus erythematosus has been reported hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma symptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiation untreated acute angle-closure glaucoma can lead to permanent vision loss the primary treatment is to discontinue hydrochlorothiazide as rapidly as possible prompt medical or surgical treatments may need to be considered if the intraocular pressure remains uncontrolled risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy all patients receiving diuretic therapy should be observed for evidence of fluid or electrolyte imbalance warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting hypokalemia may develop, especially with brisk diuresis, when severe cirrhosis is present or after prolonged therapy hypokalemia may cause cardiac arrhythmia and may also sensitize or exaggerate the response of the heart to the toxic effects of digitalis hypokalemia may be avoided or treated by use of potassium sparing diuretics or potassium supplements dilutional hyponatremia may occur in edematous patients in hot weather appropriate therapy is water restriction, rather than administration of salt, except in rare instances when the hyponatremia is life threatening in actual salt depletion, appropriate replacement is the therapy of choice hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazides in diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required hyperglycemia may occur with thiazide diuretics latent diabetes mellitus may become manifest during thiazide therapy if progressive renal impairment becomes evident, consider withholding or discontinuing diuretic therapy thiazides have been shown to increase the urinary excretion of magnesium; this may result in hypomagnesemia thiazides may decrease urinary calcium excretion marked hypercalcemia may be evidence of hidden hyperparathyroidism thiazides should be discontinued before carrying out tests for parathyroid function patients taking hydrochlorothiazide should protect skin from the sun and undergo regular skin cancer screening thiazides are excreted in breast milk; a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide Pregnancy & Lactation a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide, taking into account the importance of the drug to the mother this drug should be used during pregnancy only if clearly needed there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastric anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesias dizziness headache restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson Syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia impotence increased risk of non-melanoma skin cancer acute transient myopia acute angle-closure glaucoma (symptoms include acute onset of decreased visual acuity or ocular pain)
Hydrochlorothiazide Rx capsule Rising Pharma Holdings, Inc.	Popularity – score 100 out of 100 (most-viewed drug)	17 warnings	3 pregnancy and lactation warnings	45 side effects	Trend: was flat over the year; peak in May.
Hydrochlorothiazide® · First marketed 2007 · Label last revised September 13, 2024View full label details → Warnings Hydrochlorothiazide can cause an idiosyncratic reaction, which may result in acute transient myopia and acute angle-closure glaucoma. If acute angle-closure glaucoma is left untreated, it can lead to permanent vision loss. You should discontinue hydrochlorothiazide as quickly as possible if you experience acute angle-closure glaucoma. If you have latent diabetes mellitus, it may become apparent, and if you are a diabetic patient taking thiazides, you may need to adjust your insulin dose. If you have impaired renal function, be aware that cumulative effects of thiazides may develop. If you have impaired hepatic function, thiazides should be used with caution. Thiazides can trigger hepatic coma in patients with severe liver disease. If you are taking hydrochlorothiazide, remember to protect your skin from the sun and schedule regular skin cancer screenings. Hypokalemia may develop, especially with brisk diuresis in the presence of severe cirrhosis. Be cautious, as dilutional hyponatremia is life-threatening and may occur in edematous patients during hot weather. In certain patients receiving thiazide diuretics, hyperuricemia or acute gout may be triggered. Your healthcare provider should observe you closely to determine if the desired effect of the diuretic is achieved when using non-steroidal anti-inflammatory agents together. Thiazides should be discontinued before you undergo tests for parathyroid function. There is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults when thiazides cross the placental barrier. You and your healthcare provider should decide whether to discontinue nursing or to stop hydrochlorothiazide, considering the importance of the drug to you. Safety and effectiveness in children have not been established. If you are elderly, you may experience a greater reduction in blood pressure and an increase in side effects with hydrochlorothiazide. Pregnancy & Lactation You should decide whether to continue nursing or to stop taking hydrochlorothiazide, considering how important the medication is for you. This medication should only be used during pregnancy if it is clearly necessary. Be aware that there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Side Effects You may experience weakness. You might have hypotension, including orthostatic hypotension, which can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. Pancreatitis is a possible side effect. You could develop jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea may occur. You might experience vomiting. Sialadenitis is another potential side effect. Cramping can happen. You may experience constipation. Gastric irritation is possible. Nausea may occur. You might experience anorexia. Aplastic anemia is a serious side effect to be aware of. Agranulocytosis could occur. You may experience leukopenia. Hemolytic anemia is a potential risk. Thrombocytopenia may occur. Be aware of the possibility of anaphylactic reactions. Necrotizing angiitis, including vasculitis and cutaneous vasculitis, is a potential side effect. You might experience respiratory distress, which can include pneumonitis and pulmonary edema. Photosensitivity is a possible reaction. Fever may occur. You might experience urticaria. A rash could develop. Purpura is another potential side effect. Electrolyte imbalance may occur. You might experience hyperglycemia. Glycosuria is a possible side effect. Hyperuricemia may occur. Muscle spasms can happen. You might experience vertigo. Paresthesia is a potential side effect. Dizziness may occur. You might experience headaches. Restlessness can happen. Be aware that renal failure is a serious risk. Renal dysfunction may occur. Interstitial nephritis is a potential side effect. Erythema multiforme, including Stevens-Johnson syndrome, is a serious condition to watch for. Exfoliative dermatitis, including toxic epidermal necrolysis, may occur. Alopecia is a possible side effect. You might experience transient blurred vision. Xanthopsia could occur. Impotence is a potential side effect. There is an increased risk of non-melanoma skin cancer. Warnings hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma untreated acute angle-closure glaucoma can lead to permanent vision loss discontinue hydrochlorothiazide as rapidly as possible if acute angle-closure glaucoma occurs latent diabetes mellitus may become manifest and diabetic patients given thiazides may require adjustment of their insulin dose cumulative effects of the thiazides may develop in patients with impaired renal function thiazides should be used with caution in patients with impaired hepatic function thiazides can precipitate hepatic coma in patients with severe liver disease instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening hypokalemia may develop, especially with brisk diuresis when severe cirrhosis is present dilutional hyponatremia is life-threatening and may occur in edematous patients in hot weather hyperuricemia or acute gout may be precipitated in certain patients receiving thiazide diuretics patients should be observed closely to determine if the desired effect of the diuretic is obtained when using non-steroidal anti-inflammatory agents concomitantly thiazides should be discontinued before carrying out tests for parathyroid function there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults when thiazides cross the placental barrier a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide, taking into account the importance of the drug to the mother safety and effectiveness in pediatric patients have not been established a greater blood pressure reduction and an increase in side effects may be observed in the elderly with hydrochlorothiazide Pregnancy & Lactation a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide, taking into account the importance of the drug to the mother this drug should be used during pregnancy only if clearly needed there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastric anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesia dizziness headache restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia impotence increased risk of non-melanoma skin cancer
Hydrochlorothiazide Rx capsule Alembic Pharmaceuticals Limited	Popularity – score 100 out of 100 (most-viewed drug)	30 warnings	3 pregnancy and lactation warnings	44 side effects	Trend: was flat over the year; peak in May.
Hydrochlorothiazide® · First marketed 2017 · Label last revised January 30, 2023View full label details → Warnings Hydrochlorothiazide can cause an unusual reaction, leading to acute transient myopia and acute angle-closure glaucoma. Symptoms may include a sudden decrease in visual acuity or eye pain, typically occurring within hours to weeks after starting the medication. If left untreated, acute angle-closure glaucoma can result in permanent vision loss. The primary action you should take is to stop taking hydrochlorothiazide as quickly as possible. If you have a history of sulfonamide or penicillin allergy, you may be at higher risk for developing acute angle-closure glaucoma. If you have latent diabetes mellitus, it may become apparent, and if you are diabetic and taking thiazides, you might need to adjust your insulin dose. If you have impaired renal function, cumulative effects of thiazides may develop. In these cases, thiazides may lead to azotemia. Your healthcare provider should periodically check your serum electrolytes if you are at risk for developing hypokalemia. You should be monitored for signs of fluid or electrolyte disturbances, such as low sodium, hypochloremic alkalosis, hypokalemia, and hypomagnesemia. Hypokalemia may occur, especially with significant diuresis in the presence of severe cirrhosis. Inadequate oral electrolyte intake can also contribute to hypokalemia. Hypokalemia and hypomagnesemia can lead to ventricular arrhythmias or increase the heart's sensitivity to the toxic effects of digitalis. You can avoid or treat hypokalemia by taking potassium supplements or increasing your intake of potassium-rich foods. Dilutional hyponatremia is a serious condition that may occur in patients with edema during hot weather. The appropriate treatment is to restrict water intake rather than increase salt, except in rare cases where hyponatremia is life-threatening. Use thiazides cautiously if you have impaired liver function. They can trigger hepatic coma in individuals with severe liver disease. Thiazides decrease calcium excretion, and some patients on prolonged thiazide therapy have shown pathological changes in the parathyroid glands, along with hypercalcemia and hypophosphatemia. When taken together, alcohol, barbiturates, or narcotics may increase the risk of orthostatic hypotension. You may need to adjust the dosage of your antidiabetic medication if you are taking it alongside thiazide diuretics. Cholestyramine and colestipol resins can bind hydrochlorothiazide and reduce its absorption in the gastrointestinal tract. Corticosteroids or ACTH may worsen electrolyte depletion, particularly hypokalemia. Generally, lithium should not be taken with diuretics, as they can reduce lithium clearance and significantly raise the risk of lithium toxicity. Your healthcare provider should closely monitor you to ensure that the desired effect of the diuretic is achieved when hydrochlorothiazide is used with non-steroidal anti-inflammatory agents. Thiazides should be stopped before conducting tests for parathyroid function. There are no adequate and well-controlled studies in pregnant women; this medication should only be used during pregnancy if absolutely necessary. Thiazides can cross the placental barrier and appear in cord blood, posing risks of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions seen in adults. The safety and effectiveness of this medication in children have not been established. Elderly patients may experience a greater reduction in blood pressure and an increase in side effects when taking hydrochlorothiazide. Pregnancy & Lactation You should decide whether to continue nursing or to stop taking hydrochlorothiazide, considering how important the medication is for you. This medication should only be used during pregnancy if it is clearly necessary. Be aware that there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Side Effects You may experience weakness. You might have hypotension, including orthostatic hypotension, which can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. Pancreatitis is a possible side effect. You could develop jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea may occur. You might experience vomiting. Sialadenitis is another potential side effect. Cramping can happen. You may experience constipation. Gastric irritation is possible. Nausea may occur. You might experience anorexia. Aplastic anemia is a serious side effect to be aware of. Agranulocytosis is another potential risk. You could experience leukopenia. Hemolytic anemia may occur. Thrombocytopenia is a possible side effect. Be aware of the risk of anaphylactic reactions. Necrotizing angiitis, including vasculitis and cutaneous vasculitis, may occur. You might experience respiratory distress, which can include pneumonitis and pulmonary edema. Photosensitivity is a potential side effect. Fever may occur. You might experience urticaria. A rash could develop. Purpura is another possible side effect. Electrolyte imbalance may occur. You might experience hyperglycemia. Glycosuria is a potential side effect. Hyperuricemia may occur. Muscle spasms can happen. You might experience vertigo. Paresthesia is a possible side effect. Dizziness may occur. You might experience headaches. Restlessness can happen. Be aware that renal failure is a serious risk. Renal dysfunction may occur. Interstitial nephritis is a potential side effect. Erythema multiforme, including Stevens-Johnson syndrome, is a serious condition to watch for. Exfoliative dermatitis, including toxic epidermal necrolysis, may occur. Alopecia is a possible side effect. You might experience transient blurred vision. Xanthopsia is another potential side effect. Impotence may occur. Warnings hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma symptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiation untreated acute angle-closure glaucoma can lead to permanent vision loss the primary treatment is to discontinue hydrochlorothiazide as rapidly as possible risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy latent diabetes mellitus may become manifest and diabetic patients given thiazides may require adjustment of their insulin dose cumulative effects of the thiazides may develop in patients with impaired renal function in such patients, thiazides may precipitate azotemia periodic determination of serum electrolytes should be performed in patients who may be at risk for the development of hypokalemia patients should be observed for signs of fluid or electrolyte disturbances, i.e., hyponatremia, hypochloremic alkalosis, and hypokalemia and hypomagnesemia hypokalemia may develop, especially with brisk diuresis when severe cirrhosis is present interference with adequate oral electrolyte intake will also contribute to hypokalemia hypokalemia and hypomagnesemia can provoke ventricular arrhythmias or sensitize or exaggerate the response of the heart to the toxic effects of digitalis hypokalemia may be avoided or treated by potassium supplementation or increased intake of potassium rich foods dilutional hyponatremia is life-threatening and may occur in edematous patients in hot weather appropriate therapy is water restriction rather than salt administration, except in rare instances when the hyponatremia is life-threatening thiazides should be used with caution in patients with impaired hepatic function they can precipitate hepatic coma in patients with severe liver disease calcium excretion is decreased by thiazides, and pathologic changes in the parathyroid glands, with hypercalcemia and hypophosphatemia, have been observed in a few patients on prolonged thiazide therapy when given concurrently, alcohol, barbiturates, or narcotics may potentiate orthostatic hypotension dosage adjustment of the antidiabetic drug may be required when given concurrently with thiazide diuretics cholestyramine and colestipol resins bind the hydrochlorothiazide and reduce its absorption from the gastrointestinal tract corticosteroid or ACTH may intensify electrolyte depletion, particularly hypokalemia lithium generally should not be given with diuretics as diuretic agents reduce the renal clearance of lithium and greatly increase the risk of lithium toxicity patients should be observed closely to determine if the desired effect of the diuretic is obtained when hydrochlorothiazide and non-steroidal anti-inflammatory agents are used concomitantly thiazides should be discontinued before carrying out tests for parathyroid function there are no adequate and well-controlled studies in pregnant women; this drug should be used during pregnancy only if clearly needed thiazides cross the placental barrier and appear in cord blood; there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults safety and effectiveness in pediatric patients have not been established a greater blood pressure reduction and an increase in side effects may be observed in the elderly with hydrochlorothiazide Pregnancy & Lactation a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide, taking into account the importance of the drug to the mother this drug should be used during pregnancy only if clearly needed there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastric anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesia dizziness headache restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia impotence
Hydrochlorothiazide Rx tablet Chartwell RX, LLC	Popularity – score 100 out of 100 (most-viewed drug)	22 warnings	3 pregnancy and lactation warnings	46 side effects	Trend: was flat over the year; peak in May.
Hydrochlorothiazide® · First marketed 2015 · Label last revised December 10, 2025View full label details → Warnings Please use this medication with caution if you have severe renal disease. If you have impaired hepatic function or progressive liver disease, thiazides should be used carefully. Be aware that sensitivity reactions may occur, even if you do not have a history of allergy or bronchial asthma. There have been reports of exacerbation or activation of systemic lupus erythematosus. It's generally advised not to take lithium with diuretics. Hydrochlorothiazide can lead to an unusual reaction, resulting in acute transient myopia and acute angle-closure glaucoma. Symptoms may include a sudden decrease in visual acuity or ocular pain, typically occurring within hours to weeks after starting the medication. If acute angle-closure glaucoma is left untreated, it can result in permanent vision loss. Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. Your healthcare provider should monitor you for signs of fluid or electrolyte imbalance while you are on diuretic therapy. Warning signs of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, low blood pressure, reduced urine output, rapid heartbeat, and gastrointestinal issues like nausea and vomiting. Hypokalemia may develop, especially with brisk diuresis, in cases of severe cirrhosis, or after prolonged therapy. Hypokalemia can lead to cardiac arrhythmia and may increase the heart's sensitivity to the toxic effects of digitalis. Dilutional hyponatremia may occur in patients with edema during hot weather. In some patients receiving thiazides, hyperuricemia may occur or acute gout may be triggered. If you have diabetes, your healthcare provider may need to adjust your insulin or oral hypoglycemic agent dosages. Be aware that hyperglycemia may occur with thiazide diuretics. If you notice signs of progressive renal impairment, consider discussing with your healthcare provider the possibility of withholding or discontinuing diuretic therapy. Thiazides can increase the urinary excretion of magnesium, which may lead to hypomagnesemia. Thiazides may also decrease the excretion of calcium in urine. Marked hypercalcemia could indicate hidden hyperparathyroidism. Your healthcare provider should periodically check your serum electrolytes to detect any possible electrolyte imbalances at appropriate intervals. Pregnancy & Lactation You should use this drug during pregnancy only if it is clearly needed. Be aware that there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults. You and your healthcare provider should decide whether to discontinue nursing or to stop hydrochlorothiazide, considering how important the drug is for you. Side Effects You may experience weakness. You might have hypotension, including orthostatic hypotension, which can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. Pancreatitis is a possible side effect. You could develop jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea may occur. You might experience vomiting. Sialadenitis is another potential side effect. Cramping can happen. You may experience constipation. Gastric irritation is possible. Nausea may occur. You might have anorexia. Aplastic anemia is a serious side effect to be aware of. Agranulocytosis could occur. You may experience leukopenia. Hemolytic anemia is a potential risk. Thrombocytopenia may happen. Be aware of the possibility of anaphylactic reactions. Necrotizing angiitis, including vasculitis and cutaneous vasculitis, is a potential side effect. You might experience respiratory distress, which can include pneumonitis and pulmonary edema. Photosensitivity is a possible reaction. Fever may occur. You might develop urticaria. A rash could appear. Purpura is another potential side effect. Electrolyte imbalance may happen. You might experience hyperglycemia. Glycosuria is a possible side effect. Hyperuricemia may occur. Muscle spasms can happen. You might experience vertigo. Paresthesias may occur. Dizziness is a potential side effect. You might have headaches. Restlessness can happen. Be aware that renal failure is a serious risk. Renal dysfunction may occur. Interstitial nephritis is a potential side effect. Erythema multiforme, including Stevens-Johnson syndrome, is a serious condition to watch for. Exfoliative dermatitis, including toxic epidermal necrolysis, may occur. Alopecia is a possible side effect. You might experience transient blurred vision. Xanthopsia could occur. Impotence is a potential side effect. Acute transient myopia may happen. Be aware of the risk of acute angle-closure glaucoma. Warnings use with caution in severe renal disease thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma the possibility of exacerbation or activation of systemic lupus erythematosus has been reported lithium generally should not be given with diuretics hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma symptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiation untreated acute angle-closure glaucoma can lead to permanent vision loss risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy all patients receiving diuretic therapy should be observed for evidence of fluid or electrolyte imbalance warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting hypokalemia may develop, especially with brisk diuresis, when severe cirrhosis is present or after prolonged therapy hypokalemia may cause cardiac arrhythmia and may also sensitize or exaggerate the response of the heart to the toxic effects of digitalis dilutional hyponatremia may occur in edematous patients in hot weather hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazides in diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required hyperglycemia may occur with thiazide diuretics if progressive renal impairment becomes evident, consider withholding or discontinuing diuretic therapy thiazides have been shown to increase the urinary excretion of magnesium; this may result in hypomagnesemia thiazides may decrease urinary calcium excretion marked hypercalcemia may be evidence of hidden hyperparathyroidism periodic determination of serum electrolytes to detect possible electrolyte imbalance should be done at appropriate intervals Pregnancy & Lactation this drug should be used during pregnancy only if clearly needed there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide, taking into account the importance of the drug to the mother Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastric anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesias dizziness headache restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia impotence acute transient myopia acute angle-closure glaucoma
Hydrochlorothiazide Rx tablet Solco Healthcare U. S. , LLC	Popularity – score 100 out of 100 (most-viewed drug)	25 warnings	4 pregnancy and lactation warnings	51 side effects	Trend: was flat over the year; peak in May.
Hydrochlorothiazide® · First marketed 2002 · Label last revised May 20, 2020View full label details → Warnings Please use this medication with caution if you have severe renal disease. Thiazides may lead to azotemia if you have renal disease. If you have impaired renal function, be aware that cumulative effects of the drug may develop. Use thiazides carefully if you have impaired hepatic function or progressive liver disease. Minor changes in fluid and electrolyte balance could lead to hepatic coma. Sensitivity reactions may occur, even if you do not have a history of allergy or bronchial asthma. There have been reports of exacerbation or activation of systemic lupus erythematosus. Generally, lithium should not be taken with diuretics. If you are receiving diuretic therapy, your healthcare provider should monitor you for signs of fluid or electrolyte imbalance. Warning signs of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, low blood pressure, reduced urine output, rapid heartbeat, and gastrointestinal issues like nausea and vomiting. Hypokalemia may develop, especially with brisk diuresis, if you have severe cirrhosis or after prolonged therapy. Not getting enough oral electrolytes can also contribute to hypokalemia. Hypokalemia may lead to cardiac arrhythmia and can increase the heart's sensitivity to the toxic effects of digitalis. Dilutional hyponatremia may occur in patients with edema during hot weather. Hyperuricemia or acute gout may be triggered in some patients taking thiazides. If you have diabetes, your healthcare provider may need to adjust your insulin or oral hypoglycemic medication dosages. Hyperglycemia may occur while using thiazide diuretics. If you notice progressive renal impairment, consider discussing with your healthcare provider the possibility of withholding or stopping diuretic therapy. Thiazides can increase the urinary excretion of magnesium. Thiazides may reduce urinary calcium excretion. Marked hypercalcemia could indicate hidden hyperparathyroidism. Thiazides should be stopped before conducting tests for parathyroid function. There is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults in nursing infants. You should decide whether to continue nursing or to stop taking hydrochlorothiazide. If you are taking hydrochlorothiazide, please protect your skin from the sun and schedule regular skin cancer screenings. Pregnancy & Lactation Thiazides can be found in breast milk, so you should discuss with your healthcare provider whether to continue nursing or to stop taking hydrochlorothiazide, considering how important the medication is for you. Using diuretics routinely during a normal pregnancy is not recommended, as it may pose unnecessary risks to both you and your baby. Diuretics do not prevent the development of toxemia during pregnancy, and there is no strong evidence to support their use in treating this condition. Thiazides may be appropriate during pregnancy if the edema is caused by pathological issues. Side Effects You may experience weakness. You might have hypotension, including orthostatic hypotension, which can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. There is a possibility of developing pancreatitis. You could experience jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea may occur. You might feel nauseous and experience vomiting. Sialadenitis is a potential side effect. Cramping may happen. You could experience constipation. Gastric irritation is possible. Nausea is a common side effect. You may have a reduced appetite (anorexia). Aplastic anemia is a serious risk. Agranulocytosis may occur. You might experience leukopenia. There is a risk of hemolytic anemia. Thrombocytopenia is a potential side effect. Anaphylactic reactions can happen. You may develop necrotizing angiitis, which includes vasculitis and cutaneous vasculitis. Respiratory distress, including pneumonitis and pulmonary edema, is a possibility. Photosensitivity may occur. You might experience fever. Urticaria could develop. A rash may appear. Purpura is a potential side effect. You may experience an electrolyte imbalance. Hyperglycemia is a risk. Glycosuria may occur. Hyperuricemia is a possibility. Muscle spasms might happen. You could experience vertigo. Paresthesias may occur. Dizziness is a common side effect. You might have headaches. Restlessness could develop. There is a risk of renal failure. Renal dysfunction may occur. Interstitial nephritis is a potential side effect. Erythema multiforme, including Stevens-Johnson syndrome, is a serious risk. Exfoliative dermatitis, including toxic epidermal necrolysis, may occur. Alopecia is a possibility. You might experience transient blurred vision. Xanthopsia could develop. Impotence is a potential side effect. You have an increased risk of non-melanoma skin cancer. Acute transient myopia may occur. You could experience acute angle-closure glaucoma. Nausea and vomiting may happen. Hypokalemia is a risk. Hyperuricemia may occur. Hyperglycemia is a possibility. Warnings use with caution in severe renal disease thiazides may precipitate azotemia in patients with renal disease cumulative effects of the drug may develop in patients with impaired renal function thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease minor alterations of fluid and electrolyte balance may precipitate hepatic coma sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma the possibility of exacerbation or activation of systemic lupus erythematosus has been reported lithium generally should not be given with diuretics all patients receiving diuretic therapy should be observed for evidence of fluid or electrolyte imbalance warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting hypokalemia may develop, especially with brisk diuresis, when severe cirrhosis is present or after prolonged therapy interference with adequate oral electrolyte intake will also contribute to hypokalemia hypokalemia may cause cardiac arrhythmia and may also sensitize or exaggerate the response of the heart to the toxic effects of digitalis dilutional hyponatremia may occur in edematous patients in hot weather hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazides in diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required hyperglycemia may occur with thiazide diuretics if progressive renal impairment becomes evident, consider withholding or discontinuing diuretic therapy thiazides have been shown to increase the urinary excretion of magnesium thiazides may decrease urinary calcium excretion marked hypercalcemia may be evidence of hidden hyperparathyroidism thiazides should be discontinued before carrying out tests for parathyroid function there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults in nursing infants a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening Pregnancy & Lactation thiazides are excreted in breast milk; a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide, taking into account the importance of the drug to the mother routine use of diuretics during normal pregnancy is inappropriate and exposes mother and fetus to unnecessary hazard diuretics do not prevent development of toxemia of pregnancy and there is no satisfactory evidence that they are useful in the treatment of toxemia thiazides are indicated in pregnancy when edema is due to pathologic causes Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastic anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesias dizziness headache restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia impotence increased risk of non-melanoma skin cancer acute transient myopia acute angle-closure glaucoma nausea and vomiting hypokalemia hyperuricemia hyperglycemia
Hydrochlorothiazide Rx tablet REMEDYREPACK INC.	Popularity – score 100 out of 100 (most-viewed drug)	31 warnings	2 pregnancy and lactation warnings	46 side effects	Trend: was flat over the year; peak in May.
Hydrochlorothiazide® · First marketed 2025 · Label last revised September 30, 2025View full label details → Warnings Please use this medication with caution if you have severe renal disease. Thiazides may lead to azotemia if you have renal disease. If you have impaired renal function, be aware that cumulative effects of the drug may develop. Use thiazides carefully if you have impaired hepatic function or progressive liver disease. Minor changes in fluid and electrolyte balance could lead to hepatic coma. Sensitivity reactions may occur, even if you do not have a history of allergy or bronchial asthma. There have been reports of exacerbation or activation of systemic lupus erythematosus. You may experience acute transient myopia and acute angle-closure glaucoma. Symptoms to watch for include a sudden decrease in visual acuity or eye pain. If acute angle-closure glaucoma is left untreated, it can result in permanent vision loss. Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. If you are receiving diuretic therapy, your healthcare provider should monitor you for signs of fluid or electrolyte imbalance. Warning signs of fluid and electrolyte imbalance include dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, fatigue, low blood pressure, reduced urine output, rapid heartbeat, and gastrointestinal issues like nausea and vomiting. Hypokalemia may develop, especially with brisk diuresis, in cases of severe cirrhosis or after prolonged therapy. Hypokalemia can lead to cardiac arrhythmia and may increase the heart's sensitivity to the toxic effects of digitalis. You can avoid or treat hypokalemia by using potassium-sparing diuretics or potassium supplements. Dilutional hyponatremia may occur in patients with edema during hot weather. Hyperuricemia or acute gout may be triggered in some patients taking thiazides. If you have diabetes, your healthcare provider may need to adjust your insulin or oral hypoglycemic medication dosages. Thiazide diuretics may cause hyperglycemia. Latent diabetes mellitus may become apparent during thiazide therapy. If you notice progressive renal impairment, consider discussing with your healthcare provider the possibility of withholding or stopping diuretic therapy. Thiazides can increase the urinary excretion of magnesium, which may lead to hypomagnesemia. Thiazides may reduce urinary calcium excretion. Marked hypercalcemia could indicate hidden hyperparathyroidism. You should discontinue thiazides before undergoing tests for parathyroid function. Taking a non-steroidal anti-inflammatory agent can lessen the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing, and thiazide diuretics. Your healthcare provider should closely observe you to ensure the desired effect of the diuretic is achieved. Thiazides can cross the placental barrier and may appear in cord blood. There is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Due to the potential for serious adverse reactions in nursing infants, you should discuss with your healthcare provider whether to continue nursing or to stop taking hydrochlorothiazide. Pregnancy & Lactation You should use this drug during pregnancy only if it is clearly needed. There is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Side Effects You may experience weakness. You might have hypotension, including orthostatic hypotension, which can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. Pancreatitis is a possible side effect. You could develop jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea may occur. You might experience vomiting. Sialadenitis is another potential side effect. Cramping can happen. You may experience constipation. Gastric irritation is possible. Nausea may occur. You might experience anorexia. Aplastic anemia is a serious side effect to be aware of. Agranulocytosis could occur. You may experience leukopenia. Hemolytic anemia is a potential side effect. Thrombocytopenia may occur. Be aware of the possibility of anaphylactic reactions. Necrotizing angiitis, including vasculitis and cutaneous vasculitis, is a potential concern. You might experience respiratory distress, which can include pneumonitis and pulmonary edema. Photosensitivity is a possible side effect. Fever may occur. You might experience urticaria. A rash could develop. Purpura is another potential side effect. Electrolyte imbalance may occur. You might experience hyperglycemia. Glycosuria is a possible side effect. Hyperuricemia may occur. Muscle spasms can happen. You might experience vertigo. Paresthesias may occur. Dizziness is a potential side effect. You might experience headaches. Restlessness can happen. Be aware that renal failure is a serious concern. Renal dysfunction may occur. Interstitial nephritis is a potential side effect. Erythema multiforme, including Stevens-Johnson syndrome, is a serious condition to watch for. Exfoliative dermatitis, including toxic epidermal necrolysis, may occur. Alopecia is a possible side effect. You might experience transient blurred vision. Xanthopsia could occur. Impotence is a potential side effect. Acute transient myopia may happen. Be aware of the risk of acute angle-closure glaucoma, which can present with sudden decreased visual acuity or ocular pain. Warnings use with caution in severe renal disease thiazides may precipitate azotemia in patients with renal disease cumulative effects of the drug may develop in patients with impaired renal function thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease minor alterations of fluid and electrolyte balance may precipitate hepatic coma sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma the possibility of exacerbation or activation of systemic lupus erythematosus has been reported acute transient myopia and acute angle-closure glaucoma may occur symptoms include acute onset of decreased visual acuity or ocular pain untreated acute angle-closure glaucoma can lead to permanent vision loss risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy all patients receiving diuretic therapy should be observed for evidence of fluid or electrolyte imbalance warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting hypokalemia may develop, especially with brisk diuresis, when severe cirrhosis is present or after prolonged therapy hypokalemia may cause cardiac arrhythmia and may also sensitize or exaggerate the response of the heart to the toxic effects of digitalis hypokalemia may be avoided or treated by use of potassium sparing diuretics or potassium supplements dilutional hyponatremia may occur in edematous patients in hot weather hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazides in diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required hyperglycemia may occur with thiazide diuretics latent diabetes mellitus may become manifest during thiazide therapy if progressive renal impairment becomes evident, consider withholding or discontinuing diuretic therapy thiazides have been shown to increase the urinary excretion of magnesium; this may result in hypomagnesemia thiazides may decrease urinary calcium excretion marked hypercalcemia may be evidence of hidden hyperparathyroidism thiazides should be discontinued before carrying out tests for parathyroid function the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic and antihypertensive effects of loop, potassium-sparing and thiazide diuretics patients should be observed closely to determine if the desired effect of the diuretic is obtained thiazides cross the placental barrier and appear in cord blood there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide Pregnancy & Lactation this drug should be used during pregnancy only if clearly needed there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastric anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesias dizziness headache restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia impotence acute transient myopia acute angle-closure glaucoma (symptoms include acute onset of decreased visual acuity or ocular pain)
Hydrochlorothiazide Rx capsule Alembic Pharmaceuticals Inc.	Popularity – score 100 out of 100 (most-viewed drug)	23 warnings	3 pregnancy and lactation warnings	45 side effects	Trend: was flat over the year; peak in May.
Hydrochlorothiazide® · First marketed 2017 · Label last revised September 11, 2020View full label details → Warnings Hydrochlorothiazide can cause an unusual reaction, leading to acute transient myopia and acute angle-closure glaucoma. You may experience symptoms such as a sudden decrease in visual acuity or eye pain, which typically occur within hours to weeks after starting the medication. If left untreated, acute angle-closure glaucoma can result in permanent vision loss. The primary action is to stop taking hydrochlorothiazide as quickly as possible. If you have a history of sulfonamide or penicillin allergy, you may be at higher risk for developing acute angle-closure glaucoma. If you have latent diabetes mellitus, it may become apparent, and if you are diabetic and taking thiazides, you might need to adjust your insulin dose. If you have impaired renal function, cumulative effects of thiazides may occur. In these cases, thiazides may lead to azotemia. Your healthcare provider should periodically check your serum electrolytes if you are at risk for developing hypokalemia. You should be monitored for signs of fluid or electrolyte disturbances, such as low sodium levels, hypochloremic alkalosis, hypokalemia, and hypomagnesemia. Warning signs of fluid and electrolyte imbalance include dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pain or cramps, fatigue, low blood pressure, reduced urine output, rapid heartbeat, and gastrointestinal issues like nausea and vomiting. Hypokalemia may occur, especially with significant diuresis in the presence of severe cirrhosis. You can avoid or treat hypokalemia by taking potassium supplements or increasing your intake of potassium-rich foods. Dilutional hyponatremia is a serious condition that can happen in patients with swelling during hot weather. The appropriate treatment is to restrict water intake rather than increase salt, except in rare cases where hyponatremia is life-threatening. Use thiazides cautiously if you have impaired liver function. They can trigger hepatic coma in individuals with severe liver disease. Thiazides decrease calcium excretion, and some patients on long-term thiazide therapy have shown pathological changes in the parathyroid glands, along with hypercalcemia and hypophosphatemia. If you are taking hydrochlorothiazide, be sure to protect your skin from the sun and have regular skin cancer screenings. There is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Due to the potential for serious adverse reactions in nursing infants, you should discuss with your healthcare provider whether to continue nursing or to stop taking hydrochlorothiazide, considering the importance of the medication for you. The safety and effectiveness of this medication in children have not been established. If you are elderly (over 65 years), you may experience a greater reduction in blood pressure and an increase in side effects while taking hydrochlorothiazide. Pregnancy & Lactation You should use this drug during pregnancy only if it is clearly needed. Be aware that there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults. You and your healthcare provider should decide whether to discontinue nursing or to stop hydrochlorothiazide, considering how important the drug is for you. Side Effects You may experience weakness. Be aware that hypotension, including orthostatic hypotension, may occur and could be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. Pancreatitis is a possible side effect. You might notice jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea can occur. You may experience vomiting. Sialadenitis is another potential side effect. Cramping may happen. Constipation is possible. Gastric irritation can occur. Nausea may be experienced. You might have a decreased appetite (anorexia). Aplastic anemia is a serious side effect to be aware of. Agranulocytosis is a potential risk. Leukopenia may occur. You could experience hemolytic anemia. Thrombocytopenia is another possible side effect. Be alert for anaphylactic reactions. Necrotizing angiitis, which includes vasculitis and cutaneous vasculitis, may occur. Respiratory distress, including pneumonitis and pulmonary edema, is a serious concern. Photosensitivity can happen. You may develop a fever. Urticaria is a possible reaction. A rash may occur. Purpura is another potential side effect. Electrolyte imbalances can happen. You might experience hyperglycemia. Glycosuria is a possible side effect. Hyperuricemia may occur. Muscle spasms can happen. You might feel vertigo. Paresthesia is a potential side effect. Dizziness may occur. Headaches can happen. Restlessness is another possible side effect. Be aware that renal failure is a serious risk. Renal dysfunction may occur. Interstitial nephritis is a potential concern. Erythema multiforme, including Stevens-Johnson syndrome, is a serious side effect. Exfoliative dermatitis, including toxic epidermal necrolysis, may occur. Alopecia is a possible side effect. You might experience transient blurred vision. Xanthopsia can occur. Impotence is a potential side effect. There is a risk of non-melanoma skin cancer. Warnings hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma symptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiation untreated acute angle-closure glaucoma can lead to permanent vision loss the primary treatment is to discontinue hydrochlorothiazide as rapidly as possible risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy latent diabetes mellitus may become manifest and diabetic patients given thiazides may require adjustment of their insulin dose cumulative effects of the thiazides may develop in patients with impaired renal function in such patients, thiazides may precipitate azotemia periodic determination of serum electrolytes should be performed in patients who may be at risk for the development of hypokalemia patients should be observed for signs of fluid or electrolyte disturbances, i.e., hyponatremia, hypochloremic alkalosis, and hypokalemia and hypomagnesemia warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting hypokalemia may develop, especially with brisk diuresis when severe cirrhosis is present hypokalemia may be avoided or treated by potassium supplementation or increased intake of potassium rich foods dilutional hyponatremia is life-threatening and may occur in edematous patients in hot weather appropriate therapy is water restriction rather than salt administration, except in rare instances when the hyponatremia is life-threatening thiazides should be used with caution in patients with impaired hepatic function they can precipitate hepatic coma in patients with severe liver disease calcium excretion is decreased by thiazides, and pathologic changes in the parathyroid glands, with hypercalcemia and hypophosphatemia, have been observed in a few patients on prolonged thiazide therapy instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide, taking into account the importance of the drug to the mother safety and effectiveness in pediatric patients have not been established a greater blood pressure reduction and an increase in side effects may be observed in the elderly (i.e., >65 years) with hydrochlorothiazide Pregnancy & Lactation this drug should be used during pregnancy only if clearly needed there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide, taking into account the importance of the drug to the mother Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastric anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesia dizziness headache restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia impotence non-melanoma skin cancer
Hydrochlorothiazide Rx tablet Leading Pharma, LLC	Popularity – score 100 out of 100 (most-viewed drug)	45 warnings	0 pregnancy and lactation warnings	47 side effects	Trend: was flat over the year; peak in May.
Hydrochlorothiazide® · First marketed 2016 · Label last revised July 30, 2024View full label details → Warnings Please use this medication with caution if you have severe renal disease. Thiazides may lead to azotemia if you have renal disease. If you have impaired renal function, be aware that cumulative effects of the drug may develop. Use thiazides carefully if you have impaired hepatic function or progressive liver disease. Minor changes in fluid and electrolyte balance could lead to hepatic coma. Sensitivity reactions may occur, even if you do not have a history of allergy or bronchial asthma. There have been reports of exacerbation or activation of systemic lupus erythematosus. Generally, you should not take lithium with diuretics. Hydrochlorothiazide can cause an unusual reaction, leading to acute transient myopia and acute angle-closure glaucoma. Symptoms may include a sudden decrease in visual acuity or ocular pain, typically occurring within hours to weeks after starting the drug. If left untreated, acute angle-closure glaucoma can result in permanent vision loss. The best course of action is to stop taking hydrochlorothiazide as quickly as possible. If your intraocular pressure remains uncontrolled, prompt medical or surgical treatments may be necessary. Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. If you are receiving diuretic therapy, your healthcare provider should monitor you for signs of fluid or electrolyte imbalance. Warning signs of fluid and electrolyte imbalance include dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, low blood pressure, reduced urine output, rapid heartbeat, and gastrointestinal issues like nausea and vomiting. Hypokalemia may develop, especially with brisk diuresis, in cases of severe cirrhosis, or after prolonged therapy. Hypokalemia can lead to cardiac arrhythmia and may increase the heart's sensitivity to the toxic effects of digitalis. You can avoid or treat hypokalemia by using potassium-sparing diuretics or potassium supplements. Dilutional hyponatremia may occur in patients with edema during hot weather. The appropriate treatment is to restrict water intake, rather than adding salt, unless the hyponatremia is life-threatening. Hyperuricemia may occur, or acute gout may be triggered in some patients taking thiazides. If you have diabetes, your healthcare provider may need to adjust your insulin or oral hypoglycemic medication. Hyperglycemia can occur with thiazide diuretics. Thiazide therapy may reveal latent diabetes mellitus. If you notice progressive renal impairment, consider discussing with your healthcare provider the possibility of withholding or stopping diuretic therapy. Thiazides can increase the urinary excretion of magnesium, which may lead to hypomagnesemia. Thiazides may reduce urinary calcium excretion. Marked hypercalcemia could indicate hidden hyperparathyroidism. You should stop taking thiazides before undergoing tests for parathyroid function. If you are taking hydrochlorothiazide, protect your skin from the sun and have regular skin cancer screenings. Your healthcare provider should periodically check your serum electrolytes to detect any possible electrolyte imbalances. Be aware that alcohol, barbiturates, or narcotics may increase the risk of orthostatic hypotension. Your healthcare provider may need to adjust your antidiabetic medication dosage. There may be an additive effect or potentiation with other antihypertensive medications. The absorption of hydrochlorothiazide can be impaired by anionic exchange resins. Intensified electrolyte depletion, particularly hypokalemia, may occur with corticosteroids or ACTH. You may experience a decreased response to pressor amines, but this should not prevent their use. You might see increased responsiveness to skeletal muscle relaxants. In general, you should avoid taking lithium with diuretics due to the high risk of lithium toxicity. In some patients, taking a non-steroidal anti-inflammatory agent can reduce the effects of loop, potassium-sparing, and thiazide diuretics. Your healthcare provider should closely monitor you to ensure the diuretic is having the desired effect. Thiazides can cross the placental barrier and appear in cord blood. There is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Thiazides are excreted in breast milk; you should discuss with your healthcare provider whether to continue nursing or to stop taking hydrochlorothiazide. Pregnancy & Lactation You should use this drug during pregnancy only if it is clearly needed. Be aware that there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults. You and your healthcare provider should decide whether to discontinue nursing or to stop hydrochlorothiazide, considering how important the drug is for you. Side Effects You may experience weakness. You might have hypotension, including orthostatic hypotension, which can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. Pancreatitis is a possible side effect. You could develop jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea may occur. You might experience vomiting. Sialadenitis is another potential side effect. Cramping can happen. You may experience constipation. Gastric irritation is possible. Nausea may occur. You might experience anorexia. Aplastic anemia is a serious side effect to be aware of. Agranulocytosis is another potential risk. Leucopenia may occur. You could develop hemolytic anemia. Thrombocytopenia is a possible side effect. Be aware of the risk of anaphylactic reactions. Necrotizing angiitis, including vasculitis and cutaneous vasculitis, may occur. You might experience respiratory distress, which can include pneumonitis and pulmonary edema. Photosensitivity is a potential side effect. Fever may occur. You might experience urticaria. A rash could develop. Purpura is another possible side effect. Electrolyte imbalance may occur. You might experience hyperglycemia. Glycosuria is a potential side effect. Hyperuricemia may occur. Muscle spasms can happen. You might experience vertigo. Paresthesias may occur. Dizziness is a possible side effect. You might experience headaches. Restlessness can occur. Be aware that renal failure is a serious risk. Renal dysfunction may occur. Interstitial nephritis is another potential side effect. Erythema multiforme, including Stevens-Johnson syndrome, is a serious condition to watch for. Exfoliative dermatitis, including toxic epidermal necrolysis, may occur. Alopecia is a possible side effect. You might experience transient blurred vision. Xanthopsia may occur. Impotence is a potential side effect. Non-melanoma skin cancer is a serious risk to be aware of. Acute transient myopia may occur. Acute angle-closure glaucoma is a risk, with symptoms including a sudden decrease in visual acuity or ocular pain. Warnings use with caution in severe renal disease thiazides may precipitate azotemia in patients with renal disease cumulative effects of the drug may develop in patients with impaired renal function thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease minor alterations of fluid and electrolyte balance may precipitate hepatic coma sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma the possibility of exacerbation or activation of systemic lupus erythematosus has been reported lithium generally should not be given with diuretics hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma symptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiation untreated acute angle-closure glaucoma can lead to permanent vision loss the primary treatment is to discontinue hydrochlorothiazide as rapidly as possible prompt medical or surgical treatments may need to be considered if the intraocular pressure remains uncontrolled risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy all patients receiving diuretic therapy should be observed for evidence of fluid or electrolyte imbalance warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia and gastrointestinal disturbances such as nausea and vomiting hypokalemia may develop, especially with brisk diuresis, when severe cirrhosis is present or after prolonged therapy hypokalemia may cause cardiac arrhythmia and may also sensitize or exaggerate the response of the heart to the toxic effects of digitalis hypokalemia may be avoided or treated by use of potassium sparing diuretics or potassium supplements dilutional hyponatremia may occur in edematous patients in hot weather appropriate therapy is water restriction, rather than administration of salt, except in rare instances when the hyponatremia is life threatening hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazides in diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required hyperglycemia may occur with thiazide diuretics latent diabetes mellitus may become manifest during thiazide therapy if progressive renal impairment becomes evident, consider withholding or discontinuing diuretic therapy thiazides have been shown to increase the urinary excretion of magnesium; this may result in hypomagnesemia thiazides may decrease urinary calcium excretion marked hypercalcemia may be evidence of hidden hyperparathyroidism thiazides should be discontinued before carrying out tests for parathyroid function patients taking hydrochlorothiazide should protect skin from the sun and undergo regular skin cancer screening periodic determination of serum electrolytes to detect possible electrolyte imbalance should be done at appropriate intervals potentiation of orthostatic hypotension may occur with alcohol, barbiturates or narcotics dosage adjustment of the antidiabetic drug may be required additive effect or potentiation may occur with other antihypertensive drugs absorption of hydrochlorothiazide is impaired in the presence of anionic exchange resins intensified electrolyte depletion, particularly hypokalemia, may occur with corticosteroids or ACTH possible decreased response to pressor amines but not sufficient to preclude their use possible increased responsiveness to skeletal muscle relaxants may occur generally, lithium should not be given with diuretics due to high risk of lithium toxicity in some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic and antihypertensive effects of loop, potassium-sparing and thiazide diuretics patients should be observed closely to determine if the desired effect of the diuretic is obtained thiazides cross the placental barrier and appear in cord blood there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults thiazides are excreted in breast milk; a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide Pregnancy & Lactation No pregnancy & lactation warnings reported. Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastric anemia agranulocytosis leucopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesias dizziness headache restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia impotence non-melanoma skin cancer acute transient myopia acute angle-closure glaucoma (symptoms include acute onset of decreased visual acuity or ocular pain)
Hydrochlorothiazide Rx capsule ScieGen Pharmaceuticals Inc	Popularity – score 100 out of 100 (most-viewed drug)	19 warnings	3 pregnancy and lactation warnings	45 side effects	Trend: was flat over the year; peak in May.
Hydrochlorothiazide® · First marketed 2019 · Label last revised November 8, 2024View full label details → Warnings Hydrochlorothiazide can cause an unusual reaction, leading to acute transient myopia and acute angle-closure glaucoma. Symptoms may include a sudden decrease in visual acuity or eye pain, typically occurring within hours to weeks after starting the medication. If left untreated, acute angle-closure glaucoma can result in permanent vision loss. The main course of action is to stop taking hydrochlorothiazide as quickly as possible. You may be at risk for developing acute angle-closure glaucoma if you have a history of sulfonamide or penicillin allergy. If you have latent diabetes mellitus, it may become apparent, and if you are diabetic and taking thiazides, you might need to adjust your insulin dose. Patients with impaired renal function may experience cumulative effects from thiazides. In these patients, thiazides could lead to azotemia. Your healthcare provider should periodically check your serum electrolytes if you are at risk for developing hypokalemia. You should be monitored for signs of fluid or electrolyte disturbances, such as hyponatremia, hypochloremic alkalosis, hypokalemia, and hypomagnesemia. Warning signs of fluid and electrolyte imbalance include dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pain or cramps, fatigue, low blood pressure, reduced urine output, rapid heartbeat, and gastrointestinal issues like nausea and vomiting. Hypokalemia may occur, especially with significant diuresis in the presence of severe cirrhosis, during the use of corticosteroids or adrenocorticotropic hormone (ACTH), or after prolonged treatment. Dilutional hyponatremia is a serious condition that can happen in patients with swelling during hot weather. Thiazides should be used cautiously if you have impaired liver function. They can trigger hepatic coma in individuals with severe liver disease. Thiazides reduce calcium excretion, and some patients on long-term thiazide therapy have shown pathological changes in the parathyroid glands, along with hypercalcemia and hypophosphatemia. If you are taking hydrochlorothiazide, be sure to protect your skin from the sun and have regular skin cancer screenings. The safety and effectiveness of this medication in children have not been established. Elderly patients (those over 65 years) may experience a greater reduction in blood pressure and an increase in side effects when taking hydrochlorothiazide. Pregnancy & Lactation You should use this drug during pregnancy only if it is clearly needed. Be aware that there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults. You and your healthcare provider should decide whether to discontinue nursing or to stop hydrochlorothiazide, considering how important the drug is for you. Side Effects You may experience weakness. You might have hypotension, including orthostatic hypotension, which can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. There is a possibility of developing pancreatitis. You could experience jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea may occur. You might feel nauseous and experience vomiting. Sialadenitis is a potential side effect. Cramping may happen. You could experience constipation. Gastric irritation is possible. Nausea may be a concern. You might experience a loss of appetite (anorexia). Aplastic anemia is a serious condition that may occur. Agranulocytosis is a potential risk. You could experience leukopenia. There is a chance of hemolytic anemia. Thrombocytopenia may occur. Anaphylactic reactions are a serious risk. You might develop necrotizing angiitis, which includes vasculitis and cutaneous vasculitis. Respiratory distress, including pneumonitis and pulmonary edema, may happen. Photosensitivity is a possible side effect. You might experience fever. Urticaria could occur. A rash may develop. Purpura is a potential side effect. You may experience an electrolyte imbalance. Hyperglycemia is a possibility. Glycosuria may occur. You might experience hyperuricemia. Muscle spasms could happen. You may feel vertigo. Paresthesia is a potential side effect. Dizziness may occur. You might experience headaches. Restlessness is a possibility. Renal failure is a serious risk. You could experience renal dysfunction. Interstitial nephritis may occur. Erythema multiforme, including Stevens-Johnson syndrome, is a potential risk. Exfoliative dermatitis, including toxic epidermal necrolysis, may happen. Alopecia is a possible side effect. You might experience transient blurred vision. Xanthopsia could occur. Impotence is a potential side effect. There is an increased risk of non-melanoma skin cancer. Warnings hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma symptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiation untreated acute angle-closure glaucoma can lead to permanent vision loss the primary treatment is to discontinue hydrochlorothiazide as rapidly as possible risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy latent diabetes mellitus may become manifest and diabetic patients given thiazides may require adjustment of their insulin dose cumulative effects of the thiazides may develop in patients with impaired renal function in such patients, thiazides may precipitate azotemia periodic determination of serum electrolytes should be performed in patients who may be at risk for the development of hypokalemia patients should be observed for signs of fluid or electrolyte disturbances, i.e., hyponatremia, hypochloremic alkalosis, and hypokalemia and hypomagnesemia warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting hypokalemia may develop, especially with brisk diuresis when severe cirrhosis is present, during concomitant use of corticosteroid or adrenocorticotropic hormone (ACTH) or after prolonged therapy dilutional hyponatremia is life-threatening and may occur in edematous patients in hot weather thiazides should be used with caution in patients with impaired hepatic function they can precipitate hepatic coma in patients with severe liver disease calcium excretion is decreased by thiazides, and pathologic changes in the parathyroid glands, with hypercalcemia and hypophosphatemia, have been observed in a few patients on prolonged thiazide therapy instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening safety and effectiveness in pediatric patients have not been established a greater blood pressure reduction and an increase in side effects may be observed in the elderly (i.e., > 65 years) with hydrochlorothiazide Pregnancy & Lactation this drug should be used during pregnancy only if clearly needed there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide, taking into account the importance of the drug to the mother Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastric anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesia dizziness headache restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia impotence increased risk of non-melanoma skin cancer
Hydrochlorothiazide Rx capsule, gelatin coated Actavis Pharma, Inc.	Popularity – score 100 out of 100 (most-viewed drug)	27 warnings	3 pregnancy and lactation warnings	45 side effects	Trend: was flat over the year; peak in May.
Hydrochlorothiazide® · First marketed 1996 · Label last revised August 1, 2024View full label details → Warnings Hydrochlorothiazide can cause an unusual reaction, leading to acute transient myopia and acute angle-closure glaucoma. Symptoms may include a sudden decrease in visual acuity or eye pain, typically occurring within hours to weeks after starting the medication. If left untreated, acute angle-closure glaucoma can result in permanent vision loss. The main course of action is to stop taking hydrochlorothiazide as quickly as possible. You may be at risk for developing acute angle-closure glaucoma if you have a history of sulfonamide or penicillin allergy. If you have latent diabetes mellitus, it may become apparent, and if you are diabetic and taking thiazides, you might need to adjust your insulin dose. Patients with impaired renal function may experience cumulative effects from thiazides. In these patients, thiazides could lead to azotemia. Your healthcare provider should periodically check your serum electrolytes if you are at risk for developing hypokalemia. You should be monitored for signs of fluid or electrolyte disturbances, such as low sodium levels, hypochloremic alkalosis, hypokalemia, and hypomagnesemia. Warning signs of fluid and electrolyte imbalance include dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pain or cramps, fatigue, low blood pressure, reduced urine output, rapid heartbeat, and gastrointestinal issues like nausea and vomiting. Hypokalemia may occur, especially with significant diuresis in cases of severe cirrhosis, during the use of corticosteroids or adrenocorticotropic hormone (ACTH), or after prolonged treatment. Dilutional hyponatremia can be life-threatening and may happen in patients with swelling during hot weather. Thiazides should be used cautiously if you have impaired liver function. They can trigger hepatic coma in individuals with severe liver disease. Thiazides reduce calcium excretion, and some patients on long-term thiazide therapy have shown pathological changes in the parathyroid glands, along with hypercalcemia and hypophosphatemia. If you are taking hydrochlorothiazide, be sure to protect your skin from the sun and have regular skin cancer screenings. Alcohol, barbiturates, or narcotics may increase the risk of orthostatic hypotension. You may need to adjust the dosage of your antidiabetic medication if you are taking it alongside hydrochlorothiazide. Cholestyramine and colestipol resins can bind to hydrochlorothiazide, reducing its absorption from the gastrointestinal tract by up to 85% and 43%, respectively. Corticosteroids and ACTH may lead to increased electrolyte depletion, particularly hypokalemia. Lithium should generally not be taken with diuretics, as these medications can lower the renal clearance of lithium and significantly raise the risk of lithium toxicity. Non-steroidal anti-inflammatory drugs can diminish the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing, and thiazide diuretics. Thiazides can cross the placental barrier and appear in cord blood, which may pose risks of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions. Thiazides are also excreted in breast milk, so you should discuss with your healthcare provider whether to continue nursing or to stop taking hydrochlorothiazide, considering the importance of the medication for you. The safety and effectiveness of hydrochlorothiazide in children have not been established. Elderly patients (those over 65 years) may experience a greater reduction in blood pressure and an increase in side effects when taking hydrochlorothiazide. Pregnancy & Lactation You should use this drug during pregnancy only if it is clearly needed. Be aware that there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults. You and your healthcare provider should decide whether to discontinue nursing or to stop hydrochlorothiazide, considering how important the drug is for you. Side Effects You may experience weakness. You might have hypotension, including orthostatic hypotension, which can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. There is a possibility of developing pancreatitis. You could experience jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea may occur. You might feel nauseous and experience vomiting. Sialadenitis is a potential side effect. Cramping may happen. You could experience constipation. Gastric irritation is possible. Nausea may be a concern. You might experience a loss of appetite (anorexia). Aplastic anemia is a rare but serious side effect. Agranulocytosis may occur. You could experience leukopenia. There is a risk of hemolytic anemia. Thrombocytopenia may develop. Anaphylactic reactions are a serious concern. You might experience necrotizing angiitis, which includes vasculitis and cutaneous vasculitis. Respiratory distress, including pneumonitis and pulmonary edema, may occur. Photosensitivity is a potential side effect. You might experience fever. Urticaria could develop. A rash may occur. Purpura is a possible side effect. You may experience an electrolyte imbalance. Hyperglycemia could occur. Glycosuria is a potential concern. You might experience hyperuricemia. Muscle spasms may happen. You could feel vertigo. Paresthesia is a possible side effect. Dizziness may occur. You might experience headaches. Restlessness could develop. There is a risk of renal failure. Renal dysfunction may occur. Interstitial nephritis is a potential concern. Erythema multiforme, including Stevens-Johnson syndrome, may occur. Exfoliative dermatitis, including toxic epidermal necrolysis, is a possible side effect. Alopecia may happen. You might experience transient blurred vision. Xanthopsia is a potential side effect. Impotence may occur. There is an increased risk of non-melanoma skin cancer. Warnings hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma symptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiation untreated acute angle-closure glaucoma can lead to permanent vision loss the primary treatment is to discontinue hydrochlorothiazide as rapidly as possible risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy latent diabetes mellitus may become manifest and diabetic patients given thiazides may require adjustment of their insulin dose cumulative effects of the thiazides may develop in patients with impaired renal function in such patients, thiazides may precipitate azotemia periodic determination of serum electrolytes should be performed in patients who may be at risk for the development of hypokalemia patients should be observed for signs of fluid or electrolyte disturbances, i.e., hyponatremia, hypochloremic alkalosis, and hypokalemia and hypomagnesemia warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting hypokalemia may develop, especially with brisk diuresis when severe cirrhosis is present, during concomitant use of corticosteroid or adrenocorticotropic hormone (ACTH) or after prolonged therapy dilutional hyponatremia is life-threatening and may occur in edematous patients in hot weather thiazides should be used with caution in patients with impaired hepatic function they can precipitate hepatic coma in patients with severe liver disease calcium excretion is decreased by thiazides, and pathologic changes in the parathyroid glands, with hypercalcemia and hypophosphatemia, have been observed in a few patients on prolonged thiazide therapy instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening alcohol, barbiturates, or narcotics may cause potentiation of orthostatic hypotension dosage adjustment of the antidiabetic drug may be required when given concurrently with antidiabetic drugs (oral agents and insulin) cholestyramine and colestipol resins bind the hydrochlorothiazide and reduce its absorption from the gastrointestinal tract by up to 85 and 43 percent, respectively corticosteroid, ACTH may cause intensified electrolyte depletion, particularly hypokalemia lithium generally should not be given with diuretics as diuretic agents reduce the renal clearance of lithium and greatly increase the risk of lithium toxicity non-steroidal anti-inflammatory agents can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics thiazides cross the placental barrier and appear in cord blood, posing a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions thiazides are excreted in breast milk, and a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide, taking into account the importance of the drug to the mother safety and effectiveness in pediatric patients have not been established a greater blood pressure reduction and an increase in side effects may be observed in the elderly (i.e., > 65 years) with hydrochlorothiazide Pregnancy & Lactation this drug should be used during pregnancy only if clearly needed there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide, taking into account the importance of the drug to the mother Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastric anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesia dizziness headache restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia impotence increased risk of non-melanoma skin cancer
Hydrochlorothiazide Rx tablet Oxford Pharmaceuticals, LLC	Popularity – score 100 out of 100 (most-viewed drug)	26 warnings	3 pregnancy and lactation warnings	46 side effects	Trend: was flat over the year; peak in May.
Hydrochlorothiazide® · First marketed 2020 · Label last revised August 18, 2025View full label details → Warnings Please use this medication with caution if you have severe renal disease. If you have renal disease, thiazides may lead to azotemia. You may experience cumulative effects of the drug if you have impaired renal function. If you have impaired hepatic function or progressive liver disease, thiazides should be used with caution, as even minor changes in fluid and electrolyte balance could lead to hepatic coma. Sensitivity reactions can occur in individuals with or without a history of allergy or bronchial asthma. There have been reports of exacerbation or activation of systemic lupus erythematosus. Hydrochlorothiazide can cause an unusual reaction that may result in acute transient myopia and acute angle-closure glaucoma. Symptoms may include a sudden decrease in visual acuity or ocular pain, typically occurring within hours to weeks after starting the medication. If left untreated, acute angle-closure glaucoma can lead to permanent vision loss. Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. Your healthcare provider should monitor you for signs of fluid or electrolyte imbalance while you are on diuretic therapy. Warning signs of fluid and electrolyte imbalance include dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, low blood pressure, reduced urine output, rapid heartbeat, and gastrointestinal issues like nausea and vomiting. Hypokalemia may develop, especially with brisk diuresis, in cases of severe cirrhosis, or after prolonged therapy. Hypokalemia can lead to cardiac arrhythmias and may increase the heart's sensitivity to the toxic effects of digitalis. Dilutional hyponatremia may occur in patients with edema during hot weather. Hyperuricemia may develop, or acute gout may be triggered in certain patients taking thiazides. If you have diabetes, your healthcare provider may need to adjust your insulin or oral hypoglycemic medication dosages. You may experience hyperglycemia while taking thiazide diuretics. Latent diabetes mellitus may become apparent during thiazide therapy. If you notice progressive renal impairment, discuss with your healthcare provider the possibility of withholding or discontinuing diuretic therapy. Thiazides can increase the urinary excretion of magnesium, which may lead to hypomagnesemia. Thiazides may reduce urinary calcium excretion. Marked hypercalcemia could indicate hidden hyperparathyroidism. Please discontinue thiazides before undergoing tests for parathyroid function. If you are taking hydrochlorothiazide, remember to protect your skin from the sun and schedule regular skin cancer screenings. Thiazides are excreted in breast milk; you should discuss with your healthcare provider whether to continue nursing or to stop taking hydrochlorothiazide, considering the importance of the medication to you. Pregnancy & Lactation You should use this drug during pregnancy only if it is clearly needed. Be aware that there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults. You and your healthcare provider should decide whether to discontinue nursing or to stop hydrochlorothiazide, considering how important the drug is for you. Side Effects You may experience weakness. You might have hypotension, including orthostatic hypotension, which can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. There is a possibility of developing pancreatitis. You could experience jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea may occur. You might feel nauseous and experience vomiting. Sialadenitis is a potential side effect. Cramping may happen. You could experience constipation. Gastric irritation is possible. Nausea may be a concern. You might experience anorexia. Aplastic anemia is a rare but serious side effect. Agranulocytosis could occur. You may experience leukopenia. There is a risk of hemolytic anemia. Thrombocytopenia is a potential side effect. Anaphylactic reactions are possible. You might develop necrotizing angiitis, which includes vasculitis and cutaneous vasculitis. Respiratory distress, including pneumonitis and pulmonary edema, may occur. You could experience photosensitivity. Fever may be a side effect. Urticaria could develop. You might notice a rash. Purpura is a potential side effect. Electrolyte imbalances may occur. You could experience hyperglycemia. Glycosuria is a possibility. Hyperuricemia may occur. Muscle spasms could happen. You might feel vertigo. Paresthesias may occur. Dizziness is a potential side effect. You might experience headaches. Restlessness could be a concern. There is a risk of renal failure. Renal dysfunction may occur. Interstitial nephritis is a potential side effect. Erythema multiforme, including Stevens-Johnson syndrome, could develop. Exfoliative dermatitis, including toxic epidermal necrolysis, is a possibility. Alopecia may occur. You might experience transient blurred vision. Xanthopsia is a potential side effect. Impotence could happen. You may experience acute transient myopia. Acute angle-closure glaucoma may occur, which is characterized by a sudden decrease in visual acuity or ocular pain. Warnings use with caution in severe renal disease in patients with renal disease, thiazides may precipitate azotemia cumulative effects of the drug may develop in patients with impaired renal function thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma the possibility of exacerbation or activation of systemic lupus erythematosus has been reported hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma symptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiation untreated acute angle-closure glaucoma can lead to permanent vision loss risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy all patients receiving diuretic therapy should be observed for evidence of fluid or electrolyte imbalance warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting hypokalemia may develop, especially with brisk diuresis, when severe cirrhosis is present or after prolonged therapy hypokalemia may cause cardiac arrhythmia and may also sensitize or exaggerate the response of the heart to the toxic effects of digitalis dilutional hyponatremia may occur in edematous patients in hot weather hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazides in diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required hyperglycemia may occur with thiazide diuretics latent diabetes mellitus may become manifest during thiazide therapy if progressive renal impairment becomes evident, consider withholding or discontinuing diuretic therapy thiazides have been shown to increase the urinary excretion of magnesium; this may result in hypomagnesemia thiazides may decrease urinary calcium excretion marked hypercalcemia may be evidence of hidden hyperparathyroidism thiazides should be discontinued before carrying out tests for parathyroid function instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening thiazides are excreted in breast milk; a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide, taking into account the importance of the drug to the mother Pregnancy & Lactation this drug should be used during pregnancy only if clearly needed there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide, taking into account the importance of the drug to the mother Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastric anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesias dizziness headache restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia impotence acute transient myopia acute angle-closure glaucoma (acute onset of decreased visual acuity or ocular pain)
Hydrochlorothiazide Rx tablet Actavis Pharma, Inc.	Popularity – score 100 out of 100 (most-viewed drug)	22 warnings	3 pregnancy and lactation warnings	62 side effects	Trend: was flat over the year; peak in May.
Hydrochlorothiazide® · First marketed 2007 · Label last revised March 1, 2023View full label details → Warnings Please use this medication with caution if you have severe renal disease. If you have impaired hepatic function or progressive liver disease, thiazides should be used carefully. Sensitivity reactions may occur, even if you do not have a history of allergy or bronchial asthma. There have been reports of exacerbation or activation of systemic lupus erythematosus. You generally should not take lithium with diuretics. Be aware that acute transient myopia and acute angle-closure glaucoma may occur. If you experience symptoms of acute angle-closure glaucoma, discontinue hydrochlorothiazide as quickly as possible. Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. Your healthcare provider should monitor you for signs of fluid or electrolyte imbalance while you are on diuretic therapy. Hypokalemia may develop, especially with brisk diuresis, if you have severe cirrhosis or after prolonged therapy. Hypokalemia can lead to cardiac arrhythmia and may increase the heart's sensitivity to the toxic effects of digitalis. Dilutional hyponatremia may occur in patients with edema during hot weather. Hyperuricemia may develop, or acute gout may be triggered in some patients taking thiazides. If you have diabetes, your healthcare provider may need to adjust your insulin or oral hypoglycemic agent dosage. If you notice progressive renal impairment, consider discussing with your healthcare provider the possibility of withholding or stopping diuretic therapy. Thiazides may cause intermittent and slight elevation of serum calcium levels. Marked hypercalcemia could indicate hidden hyperparathyroidism. Thiazides should be stopped before conducting tests for parathyroid function. There are no adequate and well-controlled studies in pregnant women; this medication should only be used during pregnancy if clearly necessary. Thiazides can cross the placental barrier and appear in cord blood, which may pose risks of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions. Thiazides are excreted in breast milk; you should decide whether to continue nursing or to stop taking hydrochlorothiazide. There are no well-controlled clinical trials involving pediatric patients. Pregnancy & Lactation You should use this drug during pregnancy only if it is clearly needed. Be aware that there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults. You and your healthcare provider should decide whether to discontinue nursing or to stop hydrochlorothiazide, considering how important the drug is for you. Side Effects You may experience weakness. You might have hypotension, including orthostatic hypotension, which can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. There is a possibility of developing pancreatitis. You could experience jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea may occur. You might feel nauseous and experience vomiting. Sialadenitis is a potential side effect. Cramping may happen. You could experience constipation. Gastric irritation is possible. Nausea may be a concern. You might experience a loss of appetite (anorexia). Aplastic anemia is a rare but serious side effect. Agranulocytosis could occur. You may experience leukopenia. There is a risk of hemolytic anemia. Thrombocytopenia is a potential side effect. Anaphylactic reactions are possible. You might develop necrotizing angiitis, which includes vasculitis and cutaneous vasculitis. Respiratory distress, including pneumonitis and pulmonary edema, may occur. Photosensitivity is a possibility. You might experience fever. Urticaria could develop. A rash may occur. Purpura is a potential side effect. You may experience an electrolyte imbalance. Hyperglycemia is a possibility. Glycosuria may occur. You might experience hyperuricemia. Muscle spasms could happen. You may feel vertigo. Paresthesias might occur. Dizziness is a potential side effect. You might experience headaches. Restlessness could develop. There is a risk of renal failure. Renal dysfunction is a possibility. Interstitial nephritis may occur. Erythema multiforme, including Stevens-Johnson syndrome, is a rare but serious side effect. Exfoliative dermatitis, including toxic epidermal necrolysis, may occur. Alopecia is a potential side effect. You might experience transient blurred vision. Xanthopsia could occur. Impotence is a possibility. There is an increased risk of non-melanoma skin cancer. Acute transient myopia may occur. You might experience acute angle-closure glaucoma. Dryness of the mouth is a potential side effect. You may feel thirsty. Lethargy could develop. Drowsiness is a possibility. You might experience confusion. Seizures are a rare but serious side effect. Muscle pains or cramps may occur. You might feel muscular fatigue. Hypotension is a potential side effect. Oliguria could develop. Tachycardia is a possibility. Gastrointestinal disturbances, such as nausea and vomiting, may occur. Hypokalemia is a potential side effect. Hyperuricemia may occur. Hyperglycemia is a possibility. Warnings use with caution in severe renal disease thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma the possibility of exacerbation or activation of systemic lupus erythematosus has been reported lithium generally should not be given with diuretics acute transient myopia and acute angle-closure glaucoma may occur discontinue hydrochlorothiazide as rapidly as possible if symptoms of acute angle-closure glaucoma occur risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy all patients receiving diuretic therapy should be observed for evidence of fluid or electrolyte imbalance hypokalemia may develop, especially with brisk diuresis, when severe cirrhosis is present or after prolonged therapy hypokalemia may cause cardiac arrhythmia and may also sensitize or exaggerate the response of the heart to the toxic effects of digitalis dilutional hyponatremia may occur in edematous patients in hot weather hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazides in diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required if progressive renal impairment becomes evident, consider withholding or discontinuing diuretic therapy thiazides may cause intermittent and slight elevation of serum calcium marked hypercalcemia may be evidence of hidden hyperparathyroidism thiazides should be discontinued before carrying out tests for parathyroid function there are no adequate and well-controlled studies in pregnant women; this drug should be used during pregnancy only if clearly needed thiazides cross the placental barrier and appear in cord blood; there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions thiazides are excreted in breast milk; a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide there are no well-controlled clinical trials in pediatric patients Pregnancy & Lactation this drug should be used during pregnancy only if clearly needed there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide, taking into account the importance of the drug to the mother Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastric anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesias dizziness headache restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia impotence increased risk of non-melanoma skin cancer acute transient myopia acute angle-closure glaucoma dryness of mouth thirst lethargy drowsiness confusion seizures muscle pains or cramps muscular fatigue hypotension oliguria tachycardia gastrointestinal disturbances such as nausea and vomiting hypokalemia hyperuricemia hyperglycemia
Hydrochlorothiazide Rx tablet Exelan Pharmaceuticals Inc.	Popularity – score 100 out of 100 (most-viewed drug)	26 warnings	3 pregnancy and lactation warnings	44 side effects	Trend: was flat over the year; peak in May.
Hydrochlorothiazide® · First marketed 2016 · Label last revised December 28, 2018View full label details → Warnings Please use this medication with caution if you have severe renal disease. Thiazides may lead to azotemia if you have renal disease. If you have impaired renal function, be aware that cumulative effects of the drug may develop. Use thiazides carefully if you have impaired hepatic function or progressive liver disease. Minor changes in fluid and electrolyte balance could lead to hepatic coma. Sensitivity reactions may occur, even if you do not have a history of allergy or bronchial asthma. There have been reports of exacerbation or activation of systemic lupus erythematosus. Generally, you should not take lithium with diuretics. Your healthcare provider should monitor you for signs of fluid or electrolyte imbalance while you are on diuretic therapy. Warning signs of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, low blood pressure, reduced urine output, rapid heartbeat, and gastrointestinal issues like nausea and vomiting. Hypokalemia may develop, especially with brisk diuresis, if you have severe cirrhosis or after prolonged therapy. Not getting enough oral electrolytes can also contribute to hypokalemia. Hypokalemia may lead to cardiac arrhythmia and can increase the heart's sensitivity to the toxic effects of digitalis. Dilutional hyponatremia may occur in patients with edema during hot weather. Hyperuricemia or acute gout may be triggered in some patients taking thiazides. If you have diabetes, your healthcare provider may need to adjust your insulin or oral hypoglycemic agent dosage. You may experience hyperglycemia while taking thiazide diuretics. If you notice progressive renal impairment, consider discussing with your healthcare provider the possibility of withholding or discontinuing diuretic therapy. Thiazides can increase the urinary excretion of magnesium. Thiazides may reduce urinary calcium excretion. Marked hypercalcemia could indicate hidden hyperparathyroidism. You should stop taking thiazides before undergoing tests for parathyroid function. There are no adequate and well-controlled studies in pregnant women; this medication should only be used during pregnancy if clearly necessary. Thiazides can cross the placental barrier and appear in cord blood. There is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Due to the potential for serious adverse reactions in nursing infants, you should decide whether to continue nursing or to discontinue hydrochlorothiazide. Pregnancy & Lactation You should decide whether to continue nursing or to stop taking hydrochlorothiazide, considering how important the medication is for you. This medication should only be used during pregnancy if it is clearly necessary. Be aware that there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Side Effects You may experience weakness. You might have hypotension, including orthostatic hypotension, which can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. There is a possibility of developing pancreatitis. You could experience jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea may occur. You might feel nauseous and experience vomiting. Sialadenitis is a potential side effect. Cramping may happen. You could experience constipation. Gastric irritation is possible. Nausea may be a concern. You might experience a loss of appetite (anorexia). Aplastic anemia is a rare but serious side effect. Agranulocytosis could occur. You may experience leukopenia. There is a risk of hemolytic anemia. Thrombocytopenia is a potential side effect. Anaphylactic reactions are possible. You might develop necrotizing angiitis, which includes vasculitis and cutaneous vasculitis. Respiratory distress, including pneumonitis and pulmonary edema, may occur. You could experience photosensitivity. Fever may be a side effect. Urticaria could develop. You might notice a rash. Purpura is a potential concern. Electrolyte imbalances may occur. You could experience hyperglycemia. Glycosuria is a possibility. Hyperuricemia may occur. Muscle spasms could happen. You might feel vertigo. Paresthesias may occur. Dizziness is a potential side effect. You might experience headaches. Restlessness could be a concern. There is a risk of renal failure. Renal dysfunction may occur. Interstitial nephritis is a potential side effect. Erythema multiforme, including Stevens-Johnson Syndrome, could develop. Exfoliative dermatitis, including toxic epidermal necrolysis, is a possibility. Alopecia may occur. You might experience transient blurred vision. Xanthopsia is a potential side effect. Impotence could happen. Warnings use with caution in severe renal disease thiazides may precipitate azotemia in patients with renal disease cumulative effects of the drug may develop in patients with impaired renal function thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease minor alterations of fluid and electrolyte balance may precipitate hepatic coma sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma the possibility of exacerbation or activation of systemic lupus erythematosus has been reported lithium generally should not be given with diuretics all patients receiving diuretic therapy should be observed for evidence of fluid or electrolyte imbalance warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting hypokalemia may develop, especially with brisk diuresis, when severe cirrhosis is present or after prolonged therapy interference with adequate oral electrolyte intake will also contribute to hypokalemia hypokalemia may cause cardiac arrhythmia and may also sensitize or exaggerate the response of the heart to the toxic effects of digitalis dilutional hyponatremia may occur in edematous patients in hot weather hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazides in diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required hyperglycemia may occur with thiazide diuretics if progressive renal impairment becomes evident, consider withholding or discontinuing diuretic therapy thiazides have been shown to increase the urinary excretion of magnesium thiazides may decrease urinary calcium excretion marked hypercalcemia may be evidence of hidden hyperparathyroidism thiazides should be discontinued before carrying out tests for parathyroid function there are no adequate and well-controlled studies in pregnant women; this drug should be used during pregnancy only if clearly needed thiazides cross the placental barrier and appear in cord blood there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide Pregnancy & Lactation a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide, taking into account the importance of the drug to the mother this drug should be used during pregnancy only if clearly needed there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastric anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesias dizziness headache restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson Syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia impotence
Hydrochlorothiazide Rx tablet Accord Healthcare Inc.	Popularity – score 100 out of 100 (most-viewed drug)	19 warnings	3 pregnancy and lactation warnings	47 side effects	Trend: was flat over the year; peak in May.
Hydrochlorothiazide® · First marketed 2013 · Label last revised September 2, 2020View full label details → Warnings Please use this medication with caution if you have severe renal disease. If you have impaired hepatic function or progressive liver disease, thiazides should be used carefully, as even minor changes in fluid and electrolyte balance may lead to hepatic coma. Be aware that sensitivity reactions can occur, even if you do not have a history of allergy or bronchial asthma. There have been reports of exacerbation or activation of systemic lupus erythematosus. Acute myopia and secondary angle-closure glaucoma may develop; watch for symptoms like a sudden decrease in visual acuity or eye pain, which can occur within hours to weeks after starting the medication. If acute angle-closure glaucoma is left untreated, it can result in permanent vision loss. You may have an increased risk of developing acute angle-closure glaucoma if you have a history of sulfonamide or penicillin allergy. Your healthcare provider should monitor you for signs of fluid or electrolyte imbalance while you are on diuretic therapy. Signs of fluid and electrolyte imbalance to watch for include dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, low blood pressure, reduced urine output, rapid heartbeat, and gastrointestinal issues like nausea and vomiting. Hypokalemia may occur, particularly with brisk diuresis, in cases of severe cirrhosis, or after prolonged therapy. Hypokalemia can lead to cardiac arrhythmias and may increase the heart's sensitivity to the toxic effects of digitalis. If you notice signs of progressive renal impairment, you should discuss with your healthcare provider the possibility of withholding or stopping diuretic therapy. Thiazides may cause a slight and intermittent increase in serum calcium levels, even if you do not have known calcium metabolism disorders. Marked hypercalcemia could indicate hidden hyperparathyroidism. You should stop taking thiazides before undergoing tests for parathyroid function. There are no adequate and well-controlled studies in pregnant women; this medication should only be used during pregnancy if absolutely necessary. Thiazides can cross the placental barrier and appear in cord blood, which may pose risks such as fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions seen in adults. Due to the potential for serious adverse reactions in nursing infants, you should consider whether to continue nursing or to stop taking hydrochlorothiazide. There are no well-controlled clinical trials involving pediatric patients. Pregnancy & Lactation You should decide whether to stop nursing or to discontinue hydrochlorothiazide, considering how important the medication is for you. This medication should only be used during pregnancy if it is clearly necessary. Be aware that there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Side Effects You may experience weakness. You might have hypotension, including orthostatic hypotension, which can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. Pancreatitis is a possible side effect. You could develop jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea may occur. You might experience vomiting. Sialadenitis is another potential side effect. Cramping can happen. You may experience constipation. Gastric irritation is possible. Nausea may occur. You might have a loss of appetite (anorexia). Aplastic anemia is a potential risk. Agranulocytosis could occur. You may experience leukopenia. Hemolytic anemia is a possible side effect. Thrombocytopenia may occur. Be aware of the risk of anaphylactic reactions. Necrotizing angiitis, including vasculitis and cutaneous vasculitis, is a potential concern. You might experience respiratory distress, which can include pneumonitis and pulmonary edema. Photosensitivity is a possible side effect. Fever may occur. You might experience urticaria. A rash could develop. Purpura is another potential side effect. Electrolyte imbalance may occur. You might experience hyperglycemia. Glycosuria is a possible side effect. Hyperuricemia may occur. Muscle spasms can happen. You might experience vertigo. Paresthesias may occur. Dizziness is a possible side effect. You might have headaches. Restlessness can happen. Be aware of the risk of renal failure. Renal dysfunction is a potential concern. Interstitial nephritis may occur. Erythema multiforme, including Stevens-Johnson Syndrome, is a possible side effect. Exfoliative dermatitis, including toxic epidermal necrolysis, may occur. Alopecia is a potential side effect. You might experience transient blurred vision. Xanthopsia could occur. Impotence is a possible side effect. Non-melanoma skin cancer is a potential risk. Acute transient myopia may occur. Be aware of the risk of acute angle-closure glaucoma, which can present as a sudden decrease in visual acuity or ocular pain. Warnings use with caution in severe renal disease thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease since minor alterations of fluid and electrolyte balance may precipitate hepatic coma sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma the possibility of exacerbation or activation of systemic lupus erythematosus has been reported acute myopia and secondary angle-closure glaucoma can occur; symptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiation untreated acute angle-closure glaucoma can lead to permanent vision loss risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy all patients receiving diuretic therapy should be observed for evidence of fluid or electrolyte imbalance warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting hypokalemia may develop, especially with brisk diuresis, when severe cirrhosis is present or after prolonged therapy hypokalemia may cause cardiac arrhythmia and may also sensitize or exaggerate the response of the heart to the toxic effects of digitalis if progressive renal impairment becomes evident, consider withholding or discontinuing diuretic therapy thiazides may cause intermittent and slight elevation of serum calcium in the absence of known disorders of calcium metabolism marked hypercalcemia may be evidence of hidden hyperparathyroidism thiazides should be discontinued before carrying out tests for parathyroid function there are no adequate and well-controlled studies in pregnant women; this drug should be used during pregnancy only if clearly needed thiazides cross the placental barrier and appear in cord blood; there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide there are no well-controlled clinical trials in pediatric patients Pregnancy & Lactation a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide, taking into account the importance of the drug to the mother this drug should be used during pregnancy only if clearly needed there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastric anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesias dizziness headache restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson Syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia impotence non-melanoma skin cancer acute transient myopia acute angle-closure glaucoma (acute onset of decreased visual acuity or ocular pain)
Hydrochlorothiazide Rx tablet Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.	Popularity – score 100 out of 100 (most-viewed drug)	25 warnings	2 pregnancy and lactation warnings	47 side effects	Trend: was flat over the year; peak in May.
Hydrochlorothiazide® · First marketed 2015 · Label last revised June 2, 2025View full label details → Warnings Please use this medication with caution if you have severe renal disease. If you have impaired hepatic function or progressive liver disease, thiazides should be used carefully. Sensitivity reactions may occur, even if you do not have a history of allergy or bronchial asthma. There have been reports of exacerbation or activation of systemic lupus erythematosus. Be aware that acute transient myopia and acute angle-closure glaucoma may occur. Symptoms to watch for include a sudden decrease in visual acuity or ocular pain. If left untreated, acute angle-closure glaucoma can lead to permanent vision loss. Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. Your healthcare provider should monitor you for signs of fluid or electrolyte imbalance while you are on diuretic therapy. Warning signs of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, low blood pressure, reduced urine output, rapid heartbeat, and gastrointestinal issues like nausea and vomiting. Hypokalemia may develop, especially with brisk diuresis, in cases of severe cirrhosis, or after prolonged therapy. Hypokalemia can lead to cardiac arrhythmia and may increase the heart's sensitivity to the toxic effects of digitalis. Dilutional hyponatremia may occur in patients with edema during hot weather. Hyperuricemia may develop, or acute gout may be triggered in certain patients taking thiazides. If you are diabetic, dosage adjustments of insulin or oral hypoglycemic agents may be necessary. Be aware that hyperglycemia may occur with thiazide diuretics. If you notice progressive renal impairment, consider discussing with your healthcare provider the possibility of withholding or discontinuing diuretic therapy. Thiazides can increase the urinary excretion of magnesium, which may lead to hypomagnesemia. Thiazides may reduce urinary calcium excretion. Marked hypercalcemia could indicate hidden hyperparathyroidism. Thiazides should be stopped before conducting tests for parathyroid function. Taking a non-steroidal anti-inflammatory agent can lessen the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing, and thiazide diuretics. Thiazides can cross the placental barrier and may appear in cord blood. There is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Due to the potential for serious adverse reactions in nursing infants, you should decide whether to continue nursing or to discontinue hydrochlorothiazide. Pregnancy & Lactation You should use this drug during pregnancy only if it is clearly necessary. There is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Side Effects You may experience weakness. You might have hypotension, including orthostatic hypotension, which can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. Pancreatitis is a possible side effect. You could develop jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea may occur. You might experience vomiting. Sialadenitis is another potential side effect. Cramping can happen. You may experience constipation. Gastric irritation is possible. Nausea may occur. You might experience anorexia. Aplastic anemia is a serious side effect to be aware of. Agranulocytosis could occur. You may experience leukopenia. Hemolytic anemia is a potential risk. Thrombocytopenia may happen. Be aware of the possibility of anaphylactic reactions. Necrotizing angiitis, including vasculitis and cutaneous vasculitis, is a potential side effect. You might experience respiratory distress, which can include pneumonitis and pulmonary edema. Photosensitivity is a possible reaction. Fever may occur. You might experience urticaria. A rash could develop. Purpura is another potential side effect. Electrolyte imbalance may occur. You might experience hyperglycemia. Glycosuria is a possible side effect. Hyperuricemia may happen. Muscle spasms can occur. You might experience vertigo. Paresthesias may happen. Dizziness is a possible side effect. You may experience headaches. Restlessness could occur. Be aware that renal failure is a serious risk. Renal dysfunction may happen. Interstitial nephritis is a potential side effect. Erythema multiforme, including Stevens-Johnson syndrome, is a serious condition to watch for. Exfoliative dermatitis, including toxic epidermal necrolysis, may occur. Alopecia is a possible side effect. You might experience transient blurred vision. Xanthopsia could occur. Impotence is a potential side effect. There is an increased risk of non-melanoma skin cancer. Acute transient myopia may happen. Acute angle-closure glaucoma is a serious condition; symptoms include a sudden decrease in visual acuity or ocular pain. Warnings use with caution in severe renal disease thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma the possibility of exacerbation or activation of systemic lupus erythematosus has been reported acute transient myopia and acute angle-closure glaucoma may occur symptoms include acute onset of decreased visual acuity or ocular pain untreated acute angle-closure glaucoma can lead to permanent vision loss risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy all patients receiving diuretic therapy should be observed for evidence of fluid or electrolyte imbalance warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting hypokalemia may develop, especially with brisk diuresis, when severe cirrhosis is present or after prolonged therapy hypokalemia may cause cardiac arrhythmia and may also sensitize or exaggerate the response of the heart to the toxic effects of digitalis dilutional hyponatremia may occur in edematous patients in hot weather hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazides in diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required hyperglycemia may occur with thiazide diuretics if progressive renal impairment becomes evident, consider withholding or discontinuing diuretic therapy thiazides have been shown to increase the urinary excretion of magnesium; this may result in hypomagnesemia thiazides may decrease urinary calcium excretion marked hypercalcemia may be evidence of hidden hyperparathyroidism thiazides should be discontinued before carrying out tests for parathyroid function the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic and antihypertensive effects of loop, potassium-sparing and thiazide diuretics thiazides cross the placental barrier and appear in cord blood there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide Pregnancy & Lactation this drug should be used during pregnancy only if clearly needed there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastric anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesias dizziness headache restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia impotence increased risk of non-melanoma skin cancer acute transient myopia acute angle-closure glaucoma (symptoms include acute onset of decreased visual acuity or ocular pain)
Hydrochlorothiazide Rx capsule Unichem Pharmaceuticals (USA) , Inc.	Popularity – score 100 out of 100 (most-viewed drug)	23 warnings	3 pregnancy and lactation warnings	45 side effects	Trend: was flat over the year; peak in May.
Hydrochlorothiazide® · First marketed 2010 · Label last revised March 29, 2024View full label details → Warnings Hydrochlorothiazide can cause an unusual reaction, leading to acute transient myopia and acute angle-closure glaucoma. You may experience symptoms such as a sudden decrease in visual acuity or eye pain, which typically occur within hours to weeks after starting the medication. If left untreated, acute angle-closure glaucoma can result in permanent vision loss. You might be at higher risk for developing acute angle-closure glaucoma if you have a history of sulfonamide or penicillin allergy. If you have latent diabetes mellitus, it may become apparent, and if you are diabetic and taking thiazides, you may need to adjust your insulin dose. Patients with impaired renal function may experience cumulative effects from thiazides. If you have impaired hepatic function, thiazides should be used with caution. Thiazides can trigger hepatic coma in patients with severe liver disease. Certain patients taking thiazide diuretics may experience hyperuricemia or acute gout. If you are taking hydrochlorothiazide, be sure to protect your skin from the sun and have regular skin cancer screenings. Your healthcare provider should periodically check your serum electrolytes if you are at risk for developing hypokalemia. You should be monitored for signs of fluid or electrolyte disturbances, such as hyponatremia, hypochloremic alkalosis, hypokalemia, and hypomagnesemia. Warning signs of fluid and electrolyte imbalance include dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pain or cramps, fatigue, low blood pressure, reduced urine output, rapid heartbeat, and gastrointestinal issues like nausea and vomiting. Hypokalemia may occur, especially with significant diuresis in the presence of severe cirrhosis, during the use of corticosteroids or adrenocorticotropic hormone (ACTH), or after prolonged therapy. Dilutional hyponatremia can be life-threatening and may happen in patients with edema during hot weather. The appropriate treatment for this condition is water restriction rather than salt intake, except in rare cases where hyponatremia is life-threatening. Thiazides decrease calcium excretion, and some patients on prolonged thiazide therapy have shown pathological changes in the parathyroid glands, along with hypercalcemia and hypophosphatemia. There are no adequate and well-controlled studies in pregnant women; this medication should only be used during pregnancy if absolutely necessary. Thiazides can cross the placental barrier and appear in cord blood. There is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Thiazides are present in breast milk; you should decide whether to continue nursing or to stop taking hydrochlorothiazide, considering the importance of the medication for your health. Safety and effectiveness in children have not been established. Elderly patients (i.e., over 65 years) may experience a greater reduction in blood pressure and an increase in side effects when taking hydrochlorothiazide. Pregnancy & Lactation You should use this drug during pregnancy only if it is clearly needed. Be aware that there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults. You and your healthcare provider should decide whether to discontinue nursing or to stop hydrochlorothiazide, considering how important the drug is for you. Side Effects You may experience weakness. You might have hypotension, including orthostatic hypotension, which can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. There is a possibility of developing pancreatitis. You could experience jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea may occur. You might feel nauseous and experience vomiting. Sialadenitis is a potential side effect. Cramping may happen. You could experience constipation. Gastric irritation is possible. Nausea may be a concern. You might experience anorexia. Aplastic anemia is a rare but serious side effect. Agranulocytosis could occur. You may experience leukopenia. There is a risk of hemolytic anemia. Thrombocytopenia is a potential side effect. Anaphylactic reactions are possible. You might develop necrotizing angiitis, which includes vasculitis and cutaneous vasculitis. Respiratory distress, including pneumonitis and pulmonary edema, may occur. You could experience photosensitivity. Fever may be a side effect. Urticaria could develop. You might notice a rash. Purpura is a potential side effect. Electrolyte imbalances may occur. You could experience hyperglycemia. Glycosuria is a possibility. Hyperuricemia may occur. Muscle spasms could happen. You might feel vertigo. Paresthesia is a potential side effect. Dizziness may occur. You could experience headaches. Restlessness is possible. There is a risk of renal failure. Renal dysfunction may occur. Interstitial nephritis is a potential concern. Erythema multiforme, including Stevens-Johnson syndrome, could develop. Exfoliative dermatitis, including toxic epidermal necrolysis, is a possibility. Alopecia may occur. You might experience transient blurred vision. Xanthopsia is a potential side effect. Impotence could happen. There is an increased risk of non-melanoma skin cancer. Warnings hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma symptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiation untreated acute angle-closure glaucoma can lead to permanent vision loss risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy latent diabetes mellitus may become manifest and diabetic patients given thiazides may require adjustment of their insulin dose cumulative effects of the thiazides may develop in patients with impaired renal function thiazides should be used with caution in patients with impaired hepatic function thiazides can precipitate hepatic coma in patients with severe liver disease hyperuricemia or acute gout may be precipitated in certain patients receiving thiazide diuretics instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening periodic determination of serum electrolytes should be performed in patients who may be at risk for the development of hypokalemia patients should be observed for signs of fluid or electrolyte disturbances, i.e. hyponatremia, hypochloremic alkalosis, and hypokalemia and hypomagnesemia warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting hypokalemia may develop, especially with brisk diuresis when severe cirrhosis is present, during concomitant use of corticosteroid or adrenocorticotropic hormone (ACTH) or after prolonged therapy dilutional hyponatremia is life-threatening and may occur in edematous patients in hot weather appropriate therapy is water restriction rather than salt administration, except in rare instances when the hyponatremia is life-threatening calcium excretion is decreased by thiazides, and pathologic changes in the parathyroid glands, with hypercalcemia and hypophosphatemia, have been observed in a few patients on prolonged thiazide therapy there are no adequate and well-controlled studies in pregnant women; this drug should be used during pregnancy only if clearly needed thiazides cross the placental barrier and appear in cord blood there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults thiazides are excreted in breast milk; a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide, taking into account the importance of the drug to the mother safety and effectiveness in pediatric patients have not been established a greater blood pressure reduction and an increase in side effects may be observed in the elderly (i.e., >65 years) with hydrochlorothiazide Pregnancy & Lactation this drug should be used during pregnancy only if clearly needed there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide, taking into account the importance of the drug to the mother Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastric anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesia dizziness headache restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia impotence increased risk of non-melanoma skin cancer
Hydrochlorothiazide Rx tablet REMEDYREPACK INC.	Popularity – score 100 out of 100 (most-viewed drug)	33 warnings	2 pregnancy and lactation warnings	47 side effects	Trend: was flat over the year; peak in May.
Hydrochlorothiazide® · First marketed 2023 · Label last revised June 10, 2025View full label details → Warnings Please use this medication with caution if you have severe renal disease. Thiazides may lead to azotemia if you have renal disease. If you have impaired renal function, be aware that cumulative effects of the drug may develop. Use thiazides carefully if you have impaired hepatic function or progressive liver disease. Minor changes in fluid and electrolyte balance could lead to hepatic coma. Sensitivity reactions may occur, even if you do not have a history of allergy or bronchial asthma. There have been reports of exacerbation or activation of systemic lupus erythematosus. Hydrochlorothiazide can cause an unusual reaction, resulting in acute transient myopia and acute angle-closure glaucoma. Symptoms may include a sudden decrease in visual acuity or ocular pain, typically occurring within hours to weeks after starting the drug. If left untreated, acute angle-closure glaucoma can result in permanent vision loss. Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. If you are receiving diuretic therapy, your healthcare provider should monitor you for signs of fluid or electrolyte imbalance. Warning signs of fluid and electrolyte imbalance include dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, fatigue, low blood pressure, reduced urine output, rapid heartbeat, and gastrointestinal issues like nausea and vomiting. Hypokalemia may develop, especially with brisk diuresis, in cases of severe cirrhosis or after prolonged therapy. Hypokalemia can lead to cardiac arrhythmia and may increase the heart's sensitivity to the toxic effects of digitalis. You can avoid or treat hypokalemia by using potassium-sparing diuretics or potassium supplements. Dilutional hyponatremia may occur in patients with edema during hot weather. The appropriate treatment is to restrict water intake, rather than administering salt, unless the hyponatremia is life-threatening. Hyperuricemia may occur, or acute gout may be triggered in some patients taking thiazides. If you have diabetes, your healthcare provider may need to adjust your insulin or oral hypoglycemic medication dosages. Hyperglycemia may occur while using thiazide diuretics. Latent diabetes mellitus may become apparent during thiazide therapy. If you notice progressive renal impairment, consider discussing with your healthcare provider the possibility of withholding or discontinuing diuretic therapy. Thiazides can increase the urinary excretion of magnesium, which may lead to hypomagnesemia. Thiazides may reduce urinary calcium excretion. Marked hypercalcemia could indicate hidden hyperparathyroidism. You should discontinue thiazides before undergoing tests for parathyroid function. Taking a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing, and thiazide diuretics. Your healthcare provider should closely observe you to ensure that the desired effect of the diuretic is achieved. There are no adequate and well-controlled studies in pregnant women; this drug should only be used during pregnancy if clearly necessary. Thiazides can cross the placental barrier and appear in cord blood. There is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Due to the potential for serious adverse reactions in nursing infants, you should decide whether to continue nursing or to discontinue hydrochlorothiazide. Pregnancy & Lactation You should use this drug during pregnancy only if it is clearly necessary. There is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Side Effects You may experience weakness. You might have hypotension, including orthostatic hypotension, which can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. There is a possibility of developing pancreatitis. You could experience jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea may occur. You might feel nauseous and experience vomiting. Sialadenitis is a potential side effect. Cramping may happen. You could experience constipation. Gastric irritation is possible. Nausea may be a concern. You might experience a loss of appetite (anorexia). Aplastic anemia is a potential risk. Agranulocytosis could occur. You may experience leukopenia. There is a risk of hemolytic anemia. Thrombocytopenia may develop. Anaphylactic reactions are a serious possibility. You could experience necrotizing angiitis, which includes vasculitis and cutaneous vasculitis. Respiratory distress, including pneumonitis and pulmonary edema, may occur. Photosensitivity is a potential side effect. You might experience fever. Urticaria could develop. A rash may occur. Purpura is a possible side effect. You may experience an electrolyte imbalance. Hyperglycemia could happen. Glycosuria is a potential concern. You might experience hyperuricemia. Muscle spasms may occur. You could feel vertigo. Paresthesias might happen. Dizziness is a possible side effect. You may experience headaches. Restlessness could occur. There is a risk of renal failure. Renal dysfunction may develop. Interstitial nephritis is a potential concern. Erythema multiforme, including Stevens-Johnson syndrome, could occur. Exfoliative dermatitis, including toxic epidermal necrolysis, is a possibility. Alopecia may happen. You might experience transient blurred vision. Xanthopsia could occur. Impotence is a potential side effect. There is an increased risk of non-melanoma skin cancer. Acute transient myopia may develop. You could experience acute angle-closure glaucoma. Warnings use with caution in severe renal disease thiazides may precipitate azotemia in patients with renal disease cumulative effects of the drug may develop in patients with impaired renal function thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease minor alterations of fluid and electrolyte balance may precipitate hepatic coma sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma the possibility of exacerbation or activation of systemic lupus erythematosus has been reported hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma symptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiation untreated acute angle-closure glaucoma can lead to permanent vision loss risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy all patients receiving diuretic therapy should be observed for evidence of fluid or electrolyte imbalance warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting hypokalemia may develop, especially with brisk diuresis, when severe cirrhosis is present or after prolonged therapy hypokalemia may cause cardiac arrhythmia and may also sensitize or exaggerate the response of the heart to the toxic effects of digitalis hypokalemia may be avoided or treated by use of potassium sparing diuretics or potassium supplements dilutional hyponatremia may occur in edematous patients in hot weather appropriate therapy is water restriction, rather than administration of salt, except in rare instances when the hyponatremia is life threatening hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazides in diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required hyperglycemia may occur with thiazide diuretics latent diabetes mellitus may become manifest during thiazide therapy if progressive renal impairment becomes evident, consider withholding or discontinuing diuretic therapy thiazides have been shown to increase the urinary excretion of magnesium; this may result in hypomagnesemia thiazides may decrease urinary calcium excretion marked hypercalcemia may be evidence of hidden hyperparathyroidism thiazides should be discontinued before carrying out tests for parathyroid function the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic and antihypertensive effects of loop, potassium-sparing and thiazide diuretics the patient should be observed closely to determine if the desired effect of the diuretic is obtained there are no adequate and well-controlled studies in pregnant women; this drug should be used during pregnancy only if clearly needed thiazides cross the placental barrier and appear in cord blood there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide Pregnancy & Lactation this drug should be used during pregnancy only if clearly needed there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastric anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesias dizziness headache restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia impotence increased risk of non-melanoma skin cancer acute transient myopia acute angle-closure glaucoma
Hydrochlorothiazide Rx tablet Teva Pharmaceuticals USA, Inc.	Popularity – score 100 out of 100 (most-viewed drug)	36 warnings	3 pregnancy and lactation warnings	63 side effects	Trend: was flat over the year; peak in May.
Hydrochlorothiazide® · First marketed 1973 · Label last revised July 1, 2024View full label details → Warnings Please use this medication with caution if you have severe renal disease. Thiazides may lead to azotemia if you have renal disease. If you have impaired renal function, be aware that cumulative effects of the drug may develop. Use thiazides carefully if you have impaired hepatic function or progressive liver disease. Minor changes in fluid and electrolyte balance could lead to hepatic coma. Sensitivity reactions may occur, even if you do not have a history of allergy or bronchial asthma. There have been reports of exacerbation or activation of systemic lupus erythematosus. You generally should not take lithium with diuretics. If you are receiving diuretic therapy, your healthcare provider should monitor you for signs of fluid or electrolyte imbalance. Warning signs of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, low blood pressure, reduced urine output, rapid heartbeat, and gastrointestinal issues like nausea and vomiting. Hypokalemia may develop, especially with brisk diuresis, if you have severe cirrhosis or after prolonged therapy. Not getting enough oral electrolytes can contribute to hypokalemia. Hypokalemia may lead to cardiac arrhythmia and can increase the heart's sensitivity to the toxic effects of digitalis. Dilutional hyponatremia may occur in patients with edema during hot weather. Hyperuricemia or acute gout may be triggered in some patients taking thiazides. If you have diabetes, your healthcare provider may need to adjust your insulin or oral hypoglycemic medication. Hyperglycemia can occur with thiazide diuretics. Latent diabetes mellitus may become apparent during thiazide therapy. If you notice progressive renal impairment, consider discussing with your healthcare provider the possibility of withholding or stopping diuretic therapy. Thiazides can increase the urinary excretion of magnesium. Thiazides may reduce urinary calcium excretion. Marked hypercalcemia could indicate hidden hyperparathyroidism. Thiazides should be stopped before conducting tests for parathyroid function. If you are taking hydrochlorothiazide, please protect your skin from the sun and have regular skin cancer screenings. Your healthcare provider should periodically check your serum electrolytes to detect any possible imbalances. Be cautious, as alcohol, barbiturates, or narcotics may increase the risk of orthostatic hypotension. Your healthcare provider may need to adjust your antidiabetic medication dosage. There may be an additive effect or potentiation with other antihypertensive medications. The absorption of hydrochlorothiazide can be impaired by anionic exchange resins. Intensified electrolyte depletion, especially hypokalemia, may occur with corticosteroids or ACTH. You may experience a decreased response to pressor amines, but this should not prevent their use. You may have an increased response to muscle relaxants. Lithium generally should not be taken with diuretics, as diuretic agents can reduce lithium clearance and increase the risk of toxicity. In some patients, taking a non-steroidal anti-inflammatory agent can reduce the effects of loop, potassium-sparing, and thiazide diuretics. Thiazides can cross the placental barrier and appear in cord blood, posing a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions. Due to the potential for serious adverse reactions in nursing infants, you should discuss with your healthcare provider whether to continue nursing or to stop taking hydrochlorothiazide. Pregnancy & Lactation You should decide whether to continue nursing or to stop taking hydrochlorothiazide, considering how important the medication is for you. This medication should only be used during pregnancy if it is clearly necessary. Be aware that there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been seen in adults. Side Effects You may experience weakness. You might have hypotension, including orthostatic hypotension, which can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. Pancreatitis is a possible side effect. You could develop jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea may occur. You might experience vomiting. Sialadenitis is another potential side effect. Cramping can happen. You may experience constipation. Gastric irritation is possible. Nausea may occur. You might have a loss of appetite (anorexia). Aplastic anemia is a serious side effect to be aware of. Agranulocytosis is another potential risk. You could experience leukopenia. Hemolytic anemia may occur. Thrombocytopenia is a possible side effect. Be aware of the risk of anaphylactic reactions. Necrotizing angiitis, including vasculitis and cutaneous vasculitis, may occur. You might experience respiratory distress, which can include pneumonitis and pulmonary edema. Photosensitivity is a potential side effect. Fever may occur. You might develop urticaria. A rash could appear. Purpura is another possible side effect. Electrolyte imbalances may occur. You might experience hyperglycemia. Glycosuria is a potential side effect. Hyperuricemia may occur. Muscle spasms can happen. You might experience vertigo. Paresthesias may occur. Dizziness is a possible side effect. You might have headaches. Restlessness can occur. Be aware that renal failure is a serious risk. Renal dysfunction may happen. Interstitial nephritis is another potential side effect. Erythema multiforme, including Stevens-Johnson syndrome, may occur. Exfoliative dermatitis, including toxic epidermal necrolysis, is a possible risk. Alopecia may occur. You might experience transient blurred vision. Xanthopsia is a potential side effect. Impotence may occur. Non-melanoma skin cancer is a serious risk to consider. Acute transient myopia may develop. You could experience acute angle-closure glaucoma. Hyponatremia is a possible side effect. Hypochloremic alkalosis may occur. You might experience hypokalemia. Dryness of the mouth can happen. You may feel increased thirst. Lethargy is a potential side effect. Drowsiness may occur. Confusion is a possible side effect. Seizures are a serious risk to be aware of. You might experience muscle pains or cramps. Muscular fatigue can happen. Tachycardia is a potential side effect. Gastrointestinal disturbances, such as nausea and vomiting, may occur. Hyperuricemia may happen. Latent diabetes mellitus may become apparent during thiazide therapy. You might see increases in cholesterol and triglyceride levels. Warnings use with caution in severe renal disease thiazides may precipitate azotemia in patients with renal disease cumulative effects of the drug may develop in patients with impaired renal function thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease minor alterations of fluid and electrolyte balance may precipitate hepatic coma sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma the possibility of exacerbation or activation of systemic lupus erythematosus has been reported lithium generally should not be given with diuretics all patients receiving diuretic therapy should be observed for evidence of fluid or electrolyte imbalance warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting hypokalemia may develop, especially with brisk diuresis, when severe cirrhosis is present or after prolonged therapy interference with adequate oral electrolyte intake will contribute to hypokalemia hypokalemia may cause cardiac arrhythmia and may also sensitize or exaggerate the response of the heart to the toxic effects of digitalis dilutional hyponatremia may occur in edematous patients in hot weather hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazides in diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required hyperglycemia may occur with thiazide diuretics latent diabetes mellitus may become manifest during thiazide therapy if progressive renal impairment becomes evident, consider withholding or discontinuing diuretic therapy thiazides have been shown to increase the urinary excretion of magnesium thiazides may decrease urinary calcium excretion marked hypercalcemia may be evidence of hidden hyperparathyroidism thiazides should be discontinued before carrying out tests for parathyroid function instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening periodic determination of serum electrolytes to detect possible electrolyte imbalance should be done at appropriate intervals potentiation of orthostatic hypotension may occur with alcohol, barbiturates, or narcotics dosage adjustment of the antidiabetic drug may be required additive effect or potentiation may occur with other antihypertensive drugs absorption of hydrochlorothiazide is impaired in the presence of anionic exchange resins intensified electrolyte depletion, particularly hypokalemia, may occur with corticosteroids or ACTH possible decreased response to pressor amines but not sufficient to preclude their use possible increased responsiveness to the muscle relaxant may occur generally should not be given with diuretics; diuretic agents reduce the renal clearance of lithium and add a high risk of lithium toxicity in some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics thiazides cross the placental barrier and appear in cord blood; there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide Pregnancy & Lactation a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide, taking into account the importance of the drug to the mother this drug should be used during pregnancy only if clearly needed there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastric anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesias dizziness headache restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia impotence non-melanoma skin cancer acute transient myopia acute angle-closure glaucoma hyponatremia hypochloremic alkalosis hypokalemia dryness of mouth thirst lethargy drowsiness confusion seizures muscle pains or cramps muscular fatigue tachycardia gastrointestinal disturbances such as nausea and vomiting hyperuricemia latent diabetes mellitus may become manifest during thiazide therapy increases in cholesterol and triglyceride levels
Hydrochlorothiazide Rx capsule Aurobindo Pharma Limited	Popularity – score 100 out of 100 (most-viewed drug)	14 warnings	3 pregnancy and lactation warnings	45 side effects	Trend: was flat over the year; peak in May.
Hydrochlorothiazide® · First marketed 2007 · Label last revised June 26, 2024View full label details → Warnings If you are taking hydrochlorothiazide, be aware that it can cause an unusual reaction, leading to acute transient myopia and acute angle-closure glaucoma. Untreated acute angle-closure glaucoma can result in permanent vision loss, so it's important to seek treatment promptly. You may have a higher risk of developing acute angle-closure glaucoma if you have a history of sulfonamide or penicillin allergy. If you have latent diabetes mellitus, it may become apparent, and if you are a diabetic patient taking thiazides, you might need to adjust your insulin dose. If you have impaired renal function, be cautious as cumulative effects of thiazides may develop. If you have impaired hepatic function, thiazides should be used carefully. In patients with severe liver disease, thiazides can trigger hepatic coma. If you are taking hydrochlorothiazide, remember to protect your skin from the sun and schedule regular skin cancer screenings. Hypokalemia may occur, especially with brisk diuresis in the presence of severe cirrhosis. Be aware that dilutional hyponatremia is life-threatening and may happen in patients with edema during hot weather. If you are receiving thiazide diuretics, be mindful that hyperuricemia or acute gout may be triggered in certain individuals. Thiazides can cross the placental barrier and may appear in cord blood. There is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Due to the potential for serious adverse reactions in nursing infants, you should discuss with your healthcare provider whether to continue nursing or to stop taking hydrochlorothiazide. Pregnancy & Lactation You should decide whether to continue nursing or to stop taking hydrochlorothiazide, considering how important the medication is for you. This medication should only be used during pregnancy if it is clearly necessary. Be aware that there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Side Effects You may experience weakness. You might have hypotension, including orthostatic hypotension, which can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. There is a possibility of developing pancreatitis. You could experience jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea may occur. You might feel nauseous and experience vomiting. Sialadenitis is a potential side effect. Cramping may happen. You could experience constipation. Gastric irritation is possible. Nausea may be a concern. You might experience a loss of appetite (anorexia). Aplastic anemia is a rare but serious side effect. Agranulocytosis may occur. You could experience leukopenia. There is a risk of hemolytic anemia. Thrombocytopenia may happen. Anaphylactic reactions are a serious concern. You might develop necrotizing angiitis, which includes vasculitis and cutaneous vasculitis. Respiratory distress, including pneumonitis and pulmonary edema, may occur. You could experience photosensitivity. Fever may be a side effect. Urticaria could develop. You might notice a rash. Purpura is a potential side effect. Electrolyte imbalances may occur. You could experience hyperglycemia. Glycosuria is a possibility. Hyperuricemia may happen. Muscle spasms could occur. You might experience vertigo. Paresthesia may be a concern. Dizziness could happen. You might have headaches. Restlessness is a potential side effect. There is a risk of renal failure. Renal dysfunction may occur. Interstitial nephritis is a possibility. Erythema multiforme, including Stevens-Johnson syndrome, may occur. Exfoliative dermatitis, including toxic epidermal necrolysis, is a potential side effect. Alopecia may happen. You might experience transient blurred vision. Xanthopsia is a possibility. Impotence may occur. There is an increased risk of non-melanoma skin cancer. Warnings hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma untreated acute angle-closure glaucoma can lead to permanent vision loss risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy latent diabetes mellitus may become manifest and diabetic patients given thiazides may require adjustment of their insulin dose cumulative effects of the thiazides may develop in patients with impaired renal function thiazides should be used with caution in patients with impaired hepatic function thiazides can precipitate hepatic coma in patients with severe liver disease instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening hypokalemia may develop, especially with brisk diuresis when severe cirrhosis is present dilutional hyponatremia is life-threatening and may occur in edematous patients in hot weather hyperuricemia or acute gout may be precipitated in certain patients receiving thiazide diuretics thiazides cross the placental barrier and appear in cord blood there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide Pregnancy & Lactation a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide, taking into account the importance of the drug to the mother this drug should be used during pregnancy only if clearly needed there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastric anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesia dizziness headache restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia impotence increased risk of non-melanoma skin cancer
Hydrochlorothiazide Rx capsule AvPAK	Popularity – score 100 out of 100 (most-viewed drug)	28 warnings	3 pregnancy and lactation warnings	45 side effects	Trend: was flat over the year; peak in May.
Hydrochlorothiazide® · First marketed 2022 · Label last revised January 8, 2026View full label details → Warnings Hydrochlorothiazide can cause an unusual reaction, leading to acute transient myopia and acute angle-closure glaucoma. Symptoms may include a sudden decrease in visual acuity or eye pain, typically occurring within hours to weeks after starting the medication. If left untreated, acute angle-closure glaucoma can result in permanent vision loss. You should discontinue hydrochlorothiazide as quickly as possible. If you have a history of sulfonamide or penicillin allergy, you may be at higher risk for developing acute angle-closure glaucoma. If you have latent diabetes mellitus, it may become apparent, and if you are diabetic and taking thiazides, you might need to adjust your insulin dose. Patients with impaired renal function may experience cumulative effects from thiazides. In these patients, thiazides may lead to azotemia. Your healthcare provider should periodically check your serum electrolytes if you are at risk for developing hypokalemia. You should be monitored for signs of fluid or electrolyte disturbances, such as hyponatremia, hypochloremic alkalosis, hypokalemia, and hypomagnesemia. Warning signs of fluid and electrolyte imbalance include dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pain or cramps, fatigue, low blood pressure, reduced urine output, rapid heartbeat, and gastrointestinal issues like nausea and vomiting. Hypokalemia may occur, especially with significant diuresis in the presence of severe cirrhosis, during the use of corticosteroids or adrenocorticotropic hormone (ACTH), or after prolonged therapy. Dilutional hyponatremia can be life-threatening and may happen in patients with edema during hot weather. The appropriate treatment is to restrict water intake rather than increase salt, except in rare cases where hyponatremia is life-threatening. Thiazides should be used cautiously if you have impaired liver function. They can trigger hepatic coma in patients with severe liver disease. Thiazides decrease calcium excretion, and some patients on prolonged thiazide therapy have shown pathological changes in the parathyroid glands, along with hypercalcemia and hypophosphatemia. If you are taking hydrochlorothiazide, remember to protect your skin from the sun and schedule regular skin cancer screenings. When taken together, alcohol, barbiturates, or narcotics may increase the risk of orthostatic hypotension. You may need to adjust the dosage of your antidiabetic medication if you are taking it alongside antidiabetic drugs (oral agents and insulin). Cholestyramine and colestipol resins can bind to hydrochlorothiazide, reducing its absorption from the gastrointestinal tract by up to 85% and 43%, respectively. Corticosteroids and ACTH may lead to increased electrolyte depletion, particularly hypokalemia. Lithium should generally not be taken with diuretics, as these medications can reduce lithium clearance and significantly raise the risk of lithium toxicity. You should stop taking thiazides before undergoing tests for parathyroid function. There are no adequate and well-controlled studies in pregnant women; this medication should only be used during pregnancy if absolutely necessary. Thiazides can cross the placental barrier and appear in cord blood, posing risks of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions seen in adults. The safety and effectiveness of this medication in children have not been established. Elderly patients (i.e., over 65 years) may experience a greater reduction in blood pressure and an increase in side effects when taking hydrochlorothiazide. Pregnancy & Lactation You should decide whether to stop nursing or to discontinue hydrochlorothiazide, considering how important the medication is for you. This medication should only be used during pregnancy if it is clearly necessary. Be aware that there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Side Effects You may experience weakness. You might have hypotension, including orthostatic hypotension, which can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. There is a possibility of developing pancreatitis. You could experience jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea may occur. You might feel nauseous and experience vomiting. Sialadenitis is a potential side effect. Cramping may happen. You could experience constipation. Gastric irritation is possible. Nausea may be a concern. You might experience a loss of appetite (anorexia). Aplastic anemia is a rare but serious side effect. Agranulocytosis could occur. You may experience leukopenia. There is a risk of hemolytic anemia. Thrombocytopenia may happen. Anaphylactic reactions are a serious concern. You might develop necrotizing angiitis, which includes vasculitis and cutaneous vasculitis. Respiratory distress, including pneumonitis and pulmonary edema, may occur. You could experience photosensitivity. Fever may be a side effect. Urticaria could develop. You might notice a rash. Purpura is a potential side effect. Electrolyte imbalances may occur. You could experience hyperglycemia. Glycosuria is a possibility. Hyperuricemia may happen. Muscle spasms could occur. You might experience vertigo. Paresthesia may happen. Dizziness is a potential side effect. You might have headaches. Restlessness could occur. There is a risk of renal failure. Renal dysfunction may happen. Interstitial nephritis is a potential concern. Erythema multiforme, including Stevens-Johnson syndrome, could occur. Exfoliative dermatitis, including toxic epidermal necrolysis, is a possibility. Alopecia may happen. You might experience transient blurred vision. Xanthopsia could occur. Impotence is a potential side effect. There is an increased risk of non-melanoma skin cancer. Warnings hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma symptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiation untreated acute angle-closure glaucoma can lead to permanent vision loss discontinue hydrochlorothiazide as rapidly as possible risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy latent diabetes mellitus may become manifest and diabetic patients given thiazides may require adjustment of their insulin dose cumulative effects of the thiazides may develop in patients with impaired renal function in such patients, thiazides may precipitate azotemia periodic determination of serum electrolytes should be performed in patients who may be at risk for the development of hypokalemia patients should be observed for signs of fluid or electrolyte disturbances, i.e., hyponatremia, hypochloremic alkalosis, and hypokalemia and hypomagnesemia warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting hypokalemia may develop, especially with brisk diuresis when severe cirrhosis is present, during concomitant use of corticosteroid or adrenocorticotropic hormone (ACTH) or after prolonged therapy dilutional hyponatremia is life-threatening and may occur in edematous patients in hot weather appropriate therapy is water restriction rather than salt administration, except in rare instances when the hyponatremia is life-threatening thiazides should be used with caution in patients with impaired hepatic function they can precipitate hepatic coma in patients with severe liver disease calcium excretion is decreased by thiazides, and pathologic changes in the parathyroid glands, with hypercalcemia and hypophosphatemia, have been observed in a few patients on prolonged thiazide therapy instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening when given concurrently, alcohol, barbiturates, or narcotics may cause potentiation of orthostatic hypotension dosage adjustment of the antidiabetic drug may be required when given concurrently with antidiabetic drugs (oral agents and insulin) cholestyramine and colestipol resins bind the hydrochlorothiazide and reduce its absorption from the gastrointestinal tract by up to 85 and 43 percent, respectively corticosteroid, ACTH may cause intensified electrolyte depletion, particularly hypokalemia lithium generally should not be given with diuretics as diuretic agents reduce the renal clearance of lithium and greatly increase the risk of lithium toxicity thiazides should be discontinued before carrying out tests for parathyroid function there are no adequate and well-controlled studies in pregnant women; this drug should be used during pregnancy only if clearly needed thiazides cross the placental barrier and appear in cord blood; there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults safety and effectiveness in pediatric patients have not been established a greater blood pressure reduction and an increase in side effects may be observed in the elderly (i.e., > 65 years) with hydrochlorothiazide Pregnancy & Lactation a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide, taking into account the importance of the drug to the mother this drug should be used during pregnancy only if clearly needed there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastric anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesia dizziness headache restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia impotence increased risk of non-melanoma skin cancer
Hydrochlorothiazide Rx tablet REMEDYREPACK INC.	Popularity – score 100 out of 100 (most-viewed drug)	28 warnings	3 pregnancy and lactation warnings	52 side effects	Trend: was flat over the year; peak in May.
Hydrochlorothiazide® · First marketed 2024 · Label last revised August 14, 2025View full label details → Warnings Please use this medication with caution if you have severe renal disease. If you have renal disease, thiazides may lead to azotemia. You may experience cumulative effects of the drug if you have impaired renal function. Use thiazides carefully if you have impaired hepatic function or progressive liver disease, as even minor changes in fluid and electrolyte balance could lead to hepatic coma. Sensitivity reactions can occur whether or not you have a history of allergy or bronchial asthma. There have been reports of exacerbation or activation of systemic lupus erythematosus. Hydrochlorothiazide can cause an unusual reaction that may result in acute transient myopia and acute angle-closure glaucoma. Symptoms may include a sudden decrease in visual acuity or ocular pain, typically occurring within hours to weeks after starting the medication. If left untreated, acute angle-closure glaucoma can lead to permanent vision loss. The primary treatment is to stop taking hydrochlorothiazide as quickly as possible. If your intraocular pressure remains uncontrolled, prompt medical or surgical treatments may need to be considered. Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. If you are receiving diuretic therapy, your healthcare provider should monitor you for signs of fluid or electrolyte imbalance. Warning signs of fluid and electrolyte imbalance include dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, low blood pressure, reduced urine output, rapid heartbeat, and gastrointestinal issues like nausea and vomiting. Hypokalemia may develop, especially with brisk diuresis, in cases of severe cirrhosis or after prolonged therapy. Hypokalemia can lead to cardiac arrhythmia and may also increase the heart's sensitivity to the toxic effects of digitalis. Dilutional hyponatremia may occur in patients with edema during hot weather. Hyperuricemia may develop, or acute gout may be triggered in certain patients taking thiazides. If you are diabetic, your healthcare provider may need to adjust your insulin or oral hypoglycemic medication dosages. Hyperglycemia can occur with thiazide diuretics. Latent diabetes mellitus may become apparent during thiazide therapy. If you notice progressive renal impairment, consider discussing with your healthcare provider the possibility of withholding or stopping diuretic therapy. Thiazides can increase the urinary excretion of magnesium, which may lead to hypomagnesemia. Thiazides may reduce urinary calcium excretion. Marked hypercalcemia may indicate hidden hyperparathyroidism. Please discontinue thiazides before undergoing tests for parathyroid function. If you are taking hydrochlorothiazide, protect your skin from the sun and have regular skin cancer screenings. Thiazides are excreted in breast milk; you should discuss with your healthcare provider whether to continue nursing or to stop taking hydrochlorothiazide, considering the importance of the medication to you. Pregnancy & Lactation You should decide whether to continue nursing or to stop taking hydrochlorothiazide, considering how important the medication is for you. This medication should only be used during pregnancy if it is clearly necessary. Be aware that there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been seen in adults. Side Effects You may experience weakness. You might have hypotension, including orthostatic hypotension, which can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. There is a possibility of developing pancreatitis. You could experience jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea may occur. You might feel nauseous and experience vomiting. Sialadenitis is a potential side effect. Cramping may happen. You could experience constipation. Gastric irritation is possible. Nausea may be a concern. You might experience a loss of appetite (anorexia). Aplastic anemia is a rare but serious side effect. Agranulocytosis could occur. You may experience leukopenia. There is a risk of hemolytic anemia. Thrombocytopenia may develop. Anaphylactic reactions are a serious risk. You might experience necrotizing angiitis, which includes vasculitis and cutaneous vasculitis. Respiratory distress, including pneumonitis and pulmonary edema, may occur. Photosensitivity is a potential side effect. You might develop a fever. Urticaria could happen. A rash may develop. Purpura is a possible side effect. You may experience an electrolyte imbalance. Hyperglycemia could occur. Glycosuria may be a concern. Hyperuricemia is a potential side effect. Muscle spasms may happen. You might experience vertigo. Paresthesias could occur. Dizziness may be a concern. Headaches might develop. You may feel restless. There is a risk of renal failure. Renal dysfunction could occur. Interstitial nephritis is a potential side effect. Erythema multiforme, including Stevens-Johnson syndrome, may occur. Exfoliative dermatitis, including toxic epidermal necrolysis, is a possibility. Alopecia may happen. You might experience transient blurred vision. Xanthopsia could occur. Impotence is a potential side effect. There is an increased risk of non-melanoma skin cancer. Acute transient myopia may develop. You could experience acute angle-closure glaucoma. Decreased visual acuity is a possibility. Ocular pain may occur. Hypokalemia could happen. Hyperuricemia may develop. Latent diabetes mellitus may become apparent during thiazide therapy. Warnings use with caution in severe renal disease in patients with renal disease, thiazides may precipitate azotemia cumulative effects of the drug may develop in patients with impaired renal function thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma the possibility of exacerbation or activation of systemic lupus erythematosus has been reported hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma symptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiation untreated acute angle-closure glaucoma can lead to permanent vision loss the primary treatment is to discontinue hydrochlorothiazide as rapidly as possible prompt medical or surgical treatments may need to be considered if the intraocular pressure remains uncontrolled risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy all patients receiving diuretic therapy should be observed for evidence of fluid or electrolyte imbalance warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting hypokalemia may develop, especially with brisk diuresis, when severe cirrhosis is present or after prolonged therapy hypokalemia may cause cardiac arrhythmia and may also sensitize or exaggerate the response of the heart to the toxic effects of digitalis dilutional hyponatremia may occur in edematous patients in hot weather hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazides in diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required hyperglycemia may occur with thiazide diuretics latent diabetes mellitus may become manifest during thiazide therapy if progressive renal impairment becomes evident, consider withholding or discontinuing diuretic therapy thiazides have been shown to increase the urinary excretion of magnesium; this may result in hypomagnesemia thiazides may decrease urinary calcium excretion marked hypercalcemia may be evidence of hidden hyperparathyroidism thiazides should be discontinued before carrying out tests for parathyroid function instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening thiazides are excreted in breast milk; a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide, taking into account the importance of the drug to the mother Pregnancy & Lactation a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide, taking into account the importance of the drug to the mother this drug should be used during pregnancy only if clearly needed there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastric anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesias dizziness headache restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia impotence increased risk of non-melanoma skin cancer acute transient myopia acute angle-closure glaucoma decreased visual acuity ocular pain hypokalemia hyperuricemia latent diabetes mellitus may become manifest during thiazide therapy
Hyzaar (losartan potassium and hydrochlorothiazide) Rx tablet, film coated Organon LLC	Popularity – score 3 out of 100	7 warnings	11 pregnancy and lactation warnings	8 side effects	Trend: was flat over the year; low in Apr.
Hyzaar® · First marketed 2021 · Label last revised November 26, 2025View full label details → Warnings If you find out you are pregnant, please stop taking HYZAAR as soon as possible. Medications that directly affect the renin-angiotensin system can harm your developing fetus, potentially leading to serious injury or death. Make sure to correct any volume or salt depletion before starting HYZAAR. Your healthcare provider should regularly check your renal function and potassium levels if you are at risk. Be aware of any clinical signs that may indicate fluid or electrolyte imbalance. Be cautious of acute angle-closure glaucoma. This medication may worsen systemic lupus erythematosus. Pregnancy & Lactation HYZAAR can cause harm to your fetus if you are pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce your baby's kidney function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please stop taking HYZAAR as soon as possible. High blood pressure during pregnancy raises your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for your baby, including issues like growth restriction and stillbirth. Taking medications that affect the renin-angiotensin system in the second and third trimesters of pregnancy may lead to low amniotic fluid, reduced kidney function in your baby, lung development issues, skeletal deformities, low blood pressure, and even death. If there is no suitable alternative to using medications that affect the renin-angiotensin system for your treatment, your healthcare provider should inform you about the potential risks to your fetus. If low amniotic fluid is detected, you should stop taking HYZAAR unless it is deemed lifesaving for you. Thiazides can cross the placenta, and the levels in the umbilical vein can be similar to those in your bloodstream. Using thiazides during pregnancy may increase the risk of jaundice or low platelet counts in your baby. It's best to avoid using hydrochlorothiazide for other conditions during pregnancy. Side Effects You may experience dizziness. You might develop an upper respiratory infection. Coughing could occur. You may feel back pain. Hypotension is a possibility. Be aware of potential fluid or electrolyte imbalances. There is a risk of acute angle-closure glaucoma. You may see an exacerbation of systemic lupus erythematosus. Warnings when pregnancy is detected, discontinue HYZAAR as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume or salt depletion prior to administration of HYZAAR monitor renal function and potassium in susceptible patients observe for clinical signs of fluid or electrolyte imbalance acute angle-closure glaucoma exacerbation of systemic lupus erythematosus Pregnancy & Lactation HYZAAR can cause fetal harm when administered to a pregnant woman Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death When pregnancy is detected, discontinue HYZAAR as soon as possible Hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications Hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death Use of drugs that act on the renin-angiotensin system in the second and third trimesters of pregnancy can result in oligohydramnios, reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death In the unusual case that there is no appropriate alternative to therapy with drugs affecting the renin-angiotensin system for a particular patient, apprise the mother of the potential risk to the fetus If oligohydramnios is observed, discontinue HYZAAR, unless it is considered lifesaving for the mother Thiazides can cross the placenta, and concentrations reached in the umbilical vein approach those in the maternal plasma Use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia The use of hydrochlorothiazide for other indications in pregnancy should be avoided Side Effects dizziness upper respiratory infection cough back pain hypotension fluid or electrolyte imbalance acute angle-closure glaucoma exacerbation of systemic lupus erythematosus
Chlorothiazide (chlorothiazide sodium) Rx injection, powder, lyophilized, for solution Fresenius Kabi USA, LLC	Popularity – score 2 out of 100	35 warnings	0 pregnancy and lactation warnings	45 side effects	Trend: rose 22% over 11 months.
Chlorothiazide® · First marketed 2009 · Label last revised May 31, 2023View full label details → Warnings If you are an infant or child, intravenous use has been limited and is generally not recommended. Use this medication with caution if you have severe renal disease. If you have renal disease, thiazides may lead to azotemia. Cumulative effects of the drug may develop if you have impaired renal function. If you have impaired hepatic function or progressive liver disease, thiazides should be used with caution, as even minor changes in fluid and electrolyte balance may lead to hepatic coma. Sensitivity reactions may occur whether or not you have a history of allergy or bronchial asthma. There have been reports of exacerbation or activation of systemic lupus erythematosus. You generally should not take lithium with diuretics. If you are receiving diuretic therapy, your healthcare provider should observe you for signs of fluid or electrolyte imbalance. Serum and urine electrolyte tests are especially important if you are vomiting excessively or receiving parenteral fluids. Warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting. Hypokalemia may develop, especially with brisk diuresis, in cases of severe cirrhosis, or after prolonged therapy. Interference with adequate oral electrolyte intake can also contribute to hypokalemia. Hypokalemia may lead to cardiac arrhythmias and can sensitize or exaggerate the heart's response to the toxic effects of digitalis. You can avoid or treat hypokalemia by using potassium-sparing diuretics or potassium supplements, such as foods rich in potassium. Chloride replacement may be necessary in treating metabolic alkalosis. Dilutional hyponatremia may occur in patients with edema during hot weather. The appropriate therapy for this condition is water restriction, rather than administering salt, except in rare cases when hyponatremia is life-threatening. In cases of actual salt depletion, appropriate replacement is the therapy of choice. Hyperuricemia may occur, or acute gout may be triggered in certain patients taking thiazides. If you are diabetic, dosage adjustments of insulin or oral hypoglycemic agents may be necessary. Hyperglycemia may occur with thiazide diuretics. Latent diabetes mellitus may become apparent during thiazide therapy. If you notice progressive renal impairment, consider discussing with your healthcare provider the possibility of withholding or discontinuing diuretic therapy. Thiazides have been shown to increase urinary excretion of magnesium, which may result in hypomagnesemia. Thiazides may decrease urinary calcium excretion. Thiazides may cause intermittent and slight elevation of serum calcium in the absence of known disorders of calcium metabolism. Marked hypercalcemia may indicate hidden hyperparathyroidism. Thiazides should be discontinued before conducting tests for parathyroid function. Chlorothiazide should only be used during pregnancy if clearly needed. Chlorothiazide may cause fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults. You should decide whether to discontinue nursing or the drug, considering the importance of the medication to you. The safety and effectiveness of chlorothiazide sodium for injection in pediatric patients have not been established. When selecting a dose for an elderly patient, it should be cautious, usually starting at the low end of the dosing range. The risk of toxic reactions to this drug may be greater if you have impaired renal function. Pregnancy & Lactation You should use chlorothiazide during pregnancy only if it is clearly needed. Chlorothiazide may cause fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions. You and your healthcare provider should decide whether to discontinue nursing or to stop the medication, considering how important the drug is for you. Side Effects You may experience weakness. You might have hypotension, including orthostatic hypotension, which can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. Pancreatitis is a possible side effect. You could develop jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea may occur. You might experience vomiting. Sialadenitis is another potential side effect. Cramping can happen. You may experience constipation. Gastric irritation is possible. Nausea may occur. You might have a decreased appetite (anorexia). Aplastic anemia is a serious side effect to be aware of. Agranulocytosis is another potential risk. You could experience leukopenia. Hemolytic anemia may occur. Thrombocytopenia is a possible side effect. Be aware of the risk of anaphylactic reactions. Necrotizing angiitis, including vasculitis and cutaneous vasculitis, may occur. You might experience respiratory distress, which can include pneumonitis and pulmonary edema. Photosensitivity is a potential side effect. Fever may occur. You might experience urticaria. A rash could develop. Purpura is another possible side effect. Electrolyte imbalance may occur. You might experience hyperglycemia. Glycosuria is a potential side effect. Hyperuricemia may occur. Muscle spasms can happen. You might experience vertigo. Paresthesias may occur. Dizziness is a possible side effect. You might have headaches. Restlessness can occur. Erythema multiforme, including Stevens-Johnson syndrome, is a serious risk. Exfoliative dermatitis, including toxic epidermal necrolysis, may occur. Alopecia is a potential side effect. You might experience transient blurred vision. Xanthopsia is another possible side effect. Renal failure is a serious concern. You may experience renal dysfunction. Interstitial nephritis is a potential risk. Hematuria may occur following intravenous use. Impotence is another possible side effect. Warnings intravenous use in infants and children has been limited and is not generally recommended use with caution in severe renal disease in patients with renal disease, thiazides may precipitate azotemia cumulative effects of the drug may develop in patients with impaired renal function thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma the possibility of exacerbation or activation of systemic lupus erythematosus has been reported lithium generally should not be given with diuretics all patients receiving diuretic therapy should be observed for evidence of fluid or electrolyte imbalance serum and urine electrolyte determinations are particularly important when the patient is vomiting excessively or receiving parenteral fluids warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting hypokalemia may develop especially with brisk diuresis, when severe cirrhosis is present or after prolonged therapy interference with adequate oral electrolyte intake will also contribute to hypokalemia hypokalemia may cause cardiac arrhythmias and may also sensitize or exaggerate the response of the heart to the toxic effects of digitalis hypokalemia may be avoided or treated by use of potassium-sparing diuretics or potassium supplements such as foods with a high potassium content chloride replacement may be required in the treatment of metabolic alkalosis dilutional hyponatremia may occur in edematous patients in hot weather appropriate therapy is water restriction, rather than administration of salt, except in rare instances when the hyponatremia is life-threatening in actual salt depletion, appropriate replacement is the therapy of choice hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazides in diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required hyperglycemia may occur with thiazide diuretics latent diabetes mellitus may become manifest during thiazide therapy if progressive renal impairment becomes evident, consider withholding or discontinuing diuretic therapy thiazides have been shown to increase the urinary excretion of magnesium; this may result in hypomagnesemia thiazides may decrease urinary calcium excretion thiazides may cause intermittent and slight elevation of serum calcium in the absence of known disorders of calcium metabolism marked hypercalcemia may be evidence of hidden hyperparathyroidism thiazides should be discontinued before carrying out tests for parathyroid function chlorothiazide should be used during pregnancy only if clearly needed chlorothiazide may cause fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions which have occurred in the adult a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother safety and effectiveness of chlorothiazide sodium for injection in pediatric patients have not been established dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range the risk of toxic reactions to this drug may be greater in patients with impaired renal function Pregnancy & Lactation No pregnancy & lactation warnings reported. Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastic anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesias dizziness headache restlessness erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia renal failure renal dysfunction interstitial nephritis hematuria (following intravenous use) impotence
Chlorothiazide (chlorothiazide sodium) Rx injection, powder, lyophilized, for solution Fresenius Kabi USA, LLC	Popularity – score 2 out of 100	35 warnings	0 pregnancy and lactation warnings	45 side effects	Trend: rose 22% over 11 months.
Chlorothiazide® · First marketed 2009 · Label last revised June 2, 2023View full label details → Warnings If you are an infant or child, intravenous use has been limited and is generally not recommended. Use this medication with caution if you have severe renal disease. If you have renal disease, thiazides may lead to azotemia. Cumulative effects of the drug may develop if you have impaired renal function. If you have impaired hepatic function or progressive liver disease, thiazides should be used with caution, as even minor changes in fluid and electrolyte balance may lead to hepatic coma. Sensitivity reactions may occur whether or not you have a history of allergy or bronchial asthma. There have been reports of exacerbation or activation of systemic lupus erythematosus. You generally should not take lithium with diuretics. If you are receiving diuretic therapy, your healthcare provider should monitor you for signs of fluid or electrolyte imbalance. Serum and urine electrolyte tests are especially important if you are vomiting excessively or receiving parenteral fluids. Warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting. Hypokalemia may develop, especially with brisk diuresis, in cases of severe cirrhosis, or after prolonged therapy. Interference with adequate oral electrolyte intake can also contribute to hypokalemia. Hypokalemia may lead to cardiac arrhythmias and can sensitize or exaggerate the heart's response to the toxic effects of digitalis. You can avoid or treat hypokalemia by using potassium-sparing diuretics or potassium supplements, such as foods high in potassium. Chloride replacement may be necessary in treating metabolic alkalosis. Dilutional hyponatremia may occur in patients with edema during hot weather. The appropriate therapy for this condition is water restriction, rather than administering salt, except in rare cases when hyponatremia is life-threatening. In cases of actual salt depletion, appropriate replacement is the therapy of choice. Hyperuricemia may occur, or acute gout may be triggered in certain patients taking thiazides. If you are diabetic, dosage adjustments of insulin or oral hypoglycemic agents may be necessary. Hyperglycemia may occur with thiazide diuretics. Latent diabetes mellitus may become apparent during thiazide therapy. If you notice progressive renal impairment, consider discussing with your healthcare provider the possibility of withholding or discontinuing diuretic therapy. Thiazides have been shown to increase urinary excretion of magnesium, which may result in hypomagnesemia. Thiazides may decrease urinary calcium excretion. Thiazides may cause intermittent and slight elevation of serum calcium in the absence of known disorders of calcium metabolism. Marked hypercalcemia may indicate hidden hyperparathyroidism. Thiazides should be discontinued before conducting tests for parathyroid function. Chlorothiazide should only be used during pregnancy if clearly needed. Chlorothiazide may cause fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults. You should decide whether to discontinue nursing or the drug, considering the importance of the medication to you. The safety and effectiveness of chlorothiazide sodium for injection in pediatric patients have not been established. When selecting a dose for elderly patients, it should be cautious, usually starting at the low end of the dosing range. The risk of toxic reactions to this drug may be greater if you have impaired renal function. Pregnancy & Lactation You should use chlorothiazide during pregnancy only if it is clearly needed. Chlorothiazide may cause fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions. You and your healthcare provider should decide whether to discontinue nursing or to stop the medication, considering how important the drug is for you. Side Effects You may experience weakness. You might have hypotension, including orthostatic hypotension, which can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. There is a possibility of developing pancreatitis. You could experience jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea may occur. You might feel nauseous and experience vomiting. Sialadenitis is a potential side effect. Cramping may happen. You could experience constipation. Gastric irritation is possible. Nausea may be a concern. You might experience a loss of appetite (anorexia). Aplastic anemia is a serious side effect to be aware of. Agranulocytosis could occur. You may experience leukopenia. There is a risk of hemolytic anemia. Thrombocytopenia is another potential side effect. Anaphylactic reactions are possible. You might develop necrotizing angiitis, which includes vasculitis and cutaneous vasculitis. Respiratory distress, including pneumonitis and pulmonary edema, may occur. Photosensitivity is a potential side effect. You might experience fever. Urticaria could develop. A rash may occur. Purpura is a possible side effect. You may experience an electrolyte imbalance. Hyperglycemia is a potential concern. Glycosuria may occur. You might experience hyperuricemia. Muscle spasms could happen. You may feel vertigo. Paresthesias are possible. Dizziness may occur. Headaches could develop. You might feel restless. Erythema multiforme, including Stevens-Johnson syndrome, is a serious side effect to be aware of. Exfoliative dermatitis, including toxic epidermal necrolysis, may occur. Alopecia is a potential side effect. You might experience transient blurred vision. Xanthopsia could occur. There is a risk of renal failure. You may experience renal dysfunction. Interstitial nephritis is a potential concern. Hematuria may occur following intravenous use. Impotence is a possible side effect. Warnings intravenous use in infants and children has been limited and is not generally recommended use with caution in severe renal disease in patients with renal disease, thiazides may precipitate azotemia cumulative effects of the drug may develop in patients with impaired renal function thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma the possibility of exacerbation or activation of systemic lupus erythematosus has been reported lithium generally should not be given with diuretics all patients receiving diuretic therapy should be observed for evidence of fluid or electrolyte imbalance serum and urine electrolyte determinations are particularly important when the patient is vomiting excessively or receiving parenteral fluids warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting hypokalemia may develop especially with brisk diuresis, when severe cirrhosis is present or after prolonged therapy interference with adequate oral electrolyte intake will also contribute to hypokalemia hypokalemia may cause cardiac arrhythmias and may also sensitize or exaggerate the response of the heart to the toxic effects of digitalis hypokalemia may be avoided or treated by use of potassium-sparing diuretics or potassium supplements such as foods with a high potassium content chloride replacement may be required in the treatment of metabolic alkalosis dilutional hyponatremia may occur in edematous patients in hot weather appropriate therapy is water restriction, rather than administration of salt, except in rare instances when the hyponatremia is life-threatening in actual salt depletion, appropriate replacement is the therapy of choice hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazides in diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required hyperglycemia may occur with thiazide diuretics latent diabetes mellitus may become manifest during thiazide therapy if progressive renal impairment becomes evident, consider withholding or discontinuing diuretic therapy thiazides have been shown to increase the urinary excretion of magnesium; this may result in hypomagnesemia thiazides may decrease urinary calcium excretion thiazides may cause intermittent and slight elevation of serum calcium in the absence of known disorders of calcium metabolism marked hypercalcemia may be evidence of hidden hyperparathyroidism thiazides should be discontinued before carrying out tests for parathyroid function chlorothiazide should be used during pregnancy only if clearly needed chlorothiazide may cause fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions which have occurred in the adult a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother safety and effectiveness of chlorothiazide sodium for injection in pediatric patients have not been established dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range the risk of toxic reactions to this drug may be greater in patients with impaired renal function Pregnancy & Lactation No pregnancy & lactation warnings reported. Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastric anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesias dizziness headache restlessness erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia renal failure renal dysfunction interstitial nephritis hematuria (following intravenous use) impotence
Chlorothiazide (chlorothiazide sodium) Rx injection, powder, lyophilized, for solution Fresenius Kabi USA, LLC	Popularity – score 2 out of 100	36 warnings	2 pregnancy and lactation warnings	45 side effects	Trend: rose 22% over 11 months.
Chlorothiazide® · First marketed 2009 · Label last revised March 20, 2025View full label details → Warnings If you are an infant or child, intravenous use has been limited and is generally not recommended. Use this medication with caution if you have severe renal disease. If you have renal disease, thiazides may lead to azotemia. Cumulative effects of the drug may develop if you have impaired renal function. If you have impaired hepatic function or progressive liver disease, thiazides should be used with caution. Minor changes in fluid and electrolyte balance may lead to hepatic coma. Sensitivity reactions may occur in individuals with or without a history of allergy or bronchial asthma. There have been reports of exacerbation or activation of systemic lupus erythematosus. You should generally avoid taking lithium with diuretics. If you are receiving diuretic therapy, your healthcare provider should monitor you for signs of fluid or electrolyte imbalance. Warning signs of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, low blood pressure, reduced urine output, rapid heartbeat, and gastrointestinal issues like nausea and vomiting. Hypokalemia may develop, especially with brisk diuresis, in cases of severe cirrhosis, or after prolonged therapy. Not getting enough oral electrolytes can also contribute to hypokalemia. Hypokalemia may lead to cardiac arrhythmias and can increase the heart's sensitivity to the toxic effects of digitalis. You can avoid or treat hypokalemia by using potassium-sparing diuretics or potassium supplements, such as foods rich in potassium. While any chloride deficit is usually mild and typically doesn't require specific treatment, chloride replacement may be necessary in cases of metabolic alkalosis. Dilutional hyponatremia may occur in patients with edema during hot weather. The appropriate therapy for this condition is water restriction, rather than adding salt, except in rare cases where hyponatremia is life-threatening. In cases of actual salt depletion, appropriate replacement is the best therapy. Hyperuricemia may occur, or acute gout may be triggered in certain patients taking thiazides. If you are diabetic, dosage adjustments of insulin or oral hypoglycemic agents may be necessary. Hyperglycemia may occur with thiazide diuretics. Latent diabetes mellitus may become apparent during thiazide therapy. If you notice progressive renal impairment, consider discussing with your healthcare provider the possibility of withholding or discontinuing diuretic therapy. Thiazides have been shown to increase urinary excretion of magnesium, which may lead to hypomagnesemia. Thiazides may decrease urinary calcium excretion. Thiazides may cause slight and intermittent elevation of serum calcium in the absence of known calcium metabolism disorders. Marked hypercalcemia may indicate hidden hyperparathyroidism. You should discontinue thiazides before undergoing tests for parathyroid function. Chlorothiazide should only be used during pregnancy if clearly needed. Chlorothiazide may cause fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults. Due to the potential for serious adverse reactions in nursing infants from chlorothiazide sodium for injection, you should decide whether to continue nursing or to stop the medication. The safety and effectiveness of chlorothiazide sodium for injection in pediatric patients have not been established. In general, if you are an elderly patient, dose selection should be cautious, usually starting at the lower end of the dosing range. The risk of toxic reactions to this drug may be higher if you have impaired renal function. Care should be taken in selecting the dose for elderly patients. Pregnancy & Lactation You should use chlorothiazide during pregnancy only if it is clearly needed. It is not known whether chlorothiazide can cause harm to the fetus when given to a pregnant woman. Side Effects You may experience weakness. You might have hypotension, including orthostatic hypotension, which can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. Pancreatitis is a possible side effect. You could develop jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea may occur. You might experience vomiting. Sialadenitis is another potential side effect. Cramping can happen. You may experience constipation. Gastric irritation is possible. Nausea may occur. You might have a decreased appetite (anorexia). Aplastic anemia is a serious side effect to be aware of. Agranulocytosis is a potential risk. You could experience leukopenia. Hemolytic anemia may occur. Thrombocytopenia is another possible side effect. Be aware of the risk of anaphylactic reactions. Necrotizing angiitis, including vasculitis and cutaneous vasculitis, may occur. You might experience respiratory distress, which can include pneumonitis and pulmonary edema. Photosensitivity is a possible reaction. Fever may occur. You might develop urticaria. A rash could appear. Purpura is another potential side effect. Electrolyte imbalances may occur. You might experience hyperglycemia. Glycosuria is a possible side effect. Hyperuricemia may occur. Muscle spasms can happen. You might experience vertigo. Paresthesias may occur. Dizziness is a possible side effect. You might have headaches. Restlessness can occur. Erythema multiforme, including Stevens-Johnson syndrome, is a serious risk. Exfoliative dermatitis, including toxic epidermal necrolysis, may occur. Alopecia is a potential side effect. You might experience transient blurred vision. Xanthopsia is another possible effect. Renal failure is a serious concern. You may experience renal dysfunction. Interstitial nephritis is a potential risk. Hematuria may occur following intravenous use. Impotence is a possible side effect. Warnings intravenous use in infants and children has been limited and is not generally recommended use with caution in severe renal disease in patients with renal disease, thiazides may precipitate azotemia cumulative effects of the drug may develop in patients with impaired renal function thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease minor alterations of fluid and electrolyte balance may precipitate hepatic coma sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma the possibility of exacerbation or activation of systemic lupus erythematosus has been reported lithium generally should not be given with diuretics all patients receiving diuretic therapy should be observed for evidence of fluid or electrolyte imbalance warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting hypokalemia may develop especially with brisk diuresis, when severe cirrhosis is present or after prolonged therapy interference with adequate oral electrolyte intake will also contribute to hypokalemia hypokalemia may cause cardiac arrhythmias and may also sensitize or exaggerate the response of the heart to the toxic effects of digitalis hypokalemia may be avoided or treated by use of potassium-sparing diuretics or potassium supplements such as foods with a high potassium content although any chloride deficit is generally mild and usually does not require specific treatment except under extraordinary circumstances, chloride replacement may be required in the treatment of metabolic alkalosis dilutional hyponatremia may occur in edematous patients in hot weather appropriate therapy is water restriction, rather than administration of salt, except in rare instances when the hyponatremia is life-threatening in actual salt depletion, appropriate replacement is the therapy of choice hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazides in diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required hyperglycemia may occur with thiazide diuretics latent diabetes mellitus may become manifest during thiazide therapy if progressive renal impairment becomes evident, consider withholding or discontinuing diuretic therapy thiazides have been shown to increase the urinary excretion of magnesium; this may result in hypomagnesemia thiazides may decrease urinary calcium excretion thiazides may cause intermittent and slight elevation of serum calcium in the absence of known disorders of calcium metabolism marked hypercalcemia may be evidence of hidden hyperparathyroidism thiazides should be discontinued before carrying out tests for parathyroid function chlorothiazide should be used during pregnancy only if clearly needed chlorothiazide may cause fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions which have occurred in the adult because of the potential for serious adverse reactions in nursing infants from chlorothiazide sodium for injection, a decision should be made whether to discontinue nursing or to discontinue the drug safety and effectiveness of chlorothiazide sodium for injection in pediatric patients have not been established in general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range the risk of toxic reactions to this drug may be greater in patients with impaired renal function care should be taken in dose selection for elderly patients Pregnancy & Lactation chlorothiazide should be used during pregnancy only if clearly needed it is not known whether chlorothiazide can cause fetal harm when administered to a pregnant woman Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastric anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesias dizziness headache restlessness erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia renal failure renal dysfunction interstitial nephritis hematuria (following intravenous use) impotence
Tribenzor (olmesartan medoxomil / amlodipine besylate / hydrochlorothiazide) Rx tablet, film coated Cosette Pharmaceuticals, Inc.	Popularity – score 1 out of 100	9 warnings	10 pregnancy and lactation warnings	17 side effects	Trend: rose 26% over 11 months.
Tribenzor® · First marketed 2022 · Label last revised July 12, 2023View full label details → Warnings If you find out you are pregnant, please stop taking Tribenzor as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. Make sure to correct any volume or salt depletion before starting treatment. Your healthcare provider should monitor your renal function and potassium levels if you are at risk. Be aware that starting or increasing the dosage of calcium channel blockers may lead to increased angina or myocardial infarction. Keep an eye out for any signs of fluid or electrolyte imbalance. There may be a risk of exacerbation or activation of systemic lupus erythematosus. Acute angle-closure glaucoma is a potential concern. Sprue-like enteropathy has been reported, so consider discussing the discontinuation of Tribenzor with your healthcare provider if no other cause is identified. Pregnancy & Lactation Tribenzor can cause harm to your baby if you take it while pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of your pregnancy can reduce your baby's kidney function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please stop taking Tribenzor as soon as possible. You should consider alternative treatments for high blood pressure during your pregnancy. Using medications that affect the renin-angiotensin system during the second and third trimesters can lead to low amniotic fluid, which may result in reduced kidney function for your baby, potentially causing serious issues like kidney failure, underdeveloped lungs, skeletal deformities, low blood pressure, and even death. Thiazides can cross the placenta, and the levels in your baby's umbilical vein can be similar to those in your bloodstream. Taking thiazides during pregnancy may increase the risk of jaundice or low platelet counts in your baby. These medications should not be used to manage high blood pressure in pregnant women. It's best to avoid using HCTZ for other conditions, such as heart disease, during pregnancy. If your baby was exposed to olmesartan in the womb, your healthcare provider should closely monitor them for low blood pressure, reduced urine output, and high potassium levels. Side Effects You may experience dizziness. You might notice peripheral edema. Headaches can occur. Fatigue is a possible side effect. You could develop nasopharyngitis. Muscle spasms may happen. Nausea is something to watch for. An upper respiratory tract infection could arise. Diarrhea may occur. You might experience a urinary tract infection. Joint swelling can be a side effect. Hypotension is a possibility. If you are taking calcium channel blockers, be aware that increased angina or myocardial infarction may occur upon dosage initiation or increase. You should be mindful of fluid or electrolyte imbalances. There is a risk of exacerbation or activation of systemic lupus erythematosus. Acute angle-closure glaucoma is a potential concern. Sprue-like enteropathy may develop. Warnings when pregnancy is detected, discontinue Tribenzor as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume or salt depletion prior to administration monitor renal function and potassium in susceptible patients increased angina or myocardial infarction with calcium channel blockers may occur upon dosage initiation or increase observe for signs of fluid or electrolyte imbalance exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma sprue-like enteropathy has been reported. consider discontinuation of Tribenzor in cases where no other etiology is found Pregnancy & Lactation Tribenzor can cause fetal harm when administered to a pregnant woman Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death When pregnancy is detected, discontinue Tribenzor as soon as possible Consider alternative antihypertensive therapy during pregnancy Oligohydramnios in pregnant women who use drugs affecting the renin-angiotensin system in the second and third trimesters of pregnancy can result in reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death Thiazides can cross the placenta, and concentrations reached in the umbilical vein approach those in the maternal plasma Use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia These drugs should not be used to treat hypertension in pregnant women The use of HCTZ for other indications (e.g., heart disease) in pregnancy should be avoided Closely observe infants with histories of in utero exposure to olmesartan for hypotension, oliguria, and hyperkalemia Side Effects dizziness peripheral edema headache fatigue nasopharyngitis muscle spasms nausea upper respiratory tract infection diarrhea urinary tract infection joint swelling hypotension increased angina or myocardial infarction with calcium channel blockers upon dosage initiation or increase fluid or electrolyte imbalance exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma sprue-like enteropathy
Zestoretic (lisinopril and hydrochlorothiazide) Rx tablet Almatica Pharma Inc.	Popularity – score 1 out of 100	12 warnings	2 pregnancy and lactation warnings	82 side effects	Trend: was flat over the year; peak in Jun; bumpy overall.
Zestoretic® · First marketed 2015 · Label last revised March 31, 2025View full label details → Warnings If you find out you are pregnant, please stop taking ZESTORETIC as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially causing injury or even death. Angioedema, including swelling of the larynx, can occur at any time while you are being treated with angiotensin-converting enzyme inhibitors like ZESTORETIC. You should be aware of and report any signs or symptoms of angioedema immediately, such as swelling of the face, extremities, eyes, lips, or tongue, and difficulty swallowing or breathing. Please do not take any more of the medication until you have consulted with your prescribing physician. Be cautious and report any feelings of lightheadedness, especially during the first few days of your therapy. If you experience actual fainting, please stop taking the medication and consult with your prescribing physician. Excessive sweating and dehydration can lead to a significant drop in blood pressure due to reduced fluid volume. Do not use salt substitutes that contain potassium without first consulting your physician. Promptly report any signs of infection, such as a sore throat or fever, as these may indicate leukopenia or neutropenia. If you are a female of childbearing age, it’s important to understand the potential consequences of using ZESTORETIC during pregnancy. Please inform your physician about any pregnancies as soon as possible. If you are taking hydrochlorothiazide, remember to protect your skin from the sun and schedule regular skin cancer screenings. Pregnancy & Lactation It is not known if lisinopril is passed into human milk. You should consider whether to stop nursing and/or discontinue ZESTORETIC, keeping in mind how important the medication is for you. Side Effects You may experience dizziness (7.5%). You might have a headache (5.2%). Coughing (3.9%) can occur. Fatigue (3.7%) is another possible effect. You could notice orthostatic effects (3.2%). Diarrhea (2.5%) may happen. Nausea (2.2%) is also a possibility. An upper respiratory infection (2.2%) could develop. Muscle cramps (2.0%) might occur. You may feel asthenia (1.8%). Paresthesia (1.5%) can be experienced. Hypotension (1.4%) is a potential side effect. Vomiting (1.4%) may happen. Dyspepsia (1.3%) could occur. You might notice a rash (1.2%). Impotence (1.2%) is also a possibility. Chest pain may occur. You could experience abdominal pain. Syncope might happen. Chest discomfort can be felt. Fever may develop. Trauma could occur. You might contract a virus infection. Palpitations may happen. Orthostatic hypotension could occur. Gastrointestinal cramps might be experienced. You may have a dry mouth. Constipation can occur. Heartburn might happen. You could feel back pain. Shoulder pain may develop. Knee pain might occur. Back strain could happen. Myalgia may be experienced. Foot pain might occur. You may notice a decreased libido. Vertigo can happen. Depression might be experienced. Somnolence may occur. You could catch a common cold. Nasal congestion might happen. Influenza may develop. Bronchitis could occur. You might feel pharyngeal pain. Dyspnea may happen. Pulmonary congestion could occur. Chronic sinusitis might develop. You may experience allergic rhinitis. Pharyngeal discomfort can occur. Flushing might happen. You could experience pruritus. Skin inflammation may occur. Diaphoresis might happen. You could develop cutaneous pseudolymphoma. Blurred vision may occur. Tinnitus might happen. You may feel otalgia. An urinary tract infection could develop. Angioedema of the face, extremities, lips, tongue, glottis and/or larynx may occur. Intestinal angioedema could happen. Hypotension (1.4%) is a potential side effect. Orthostatic hypotension (0.5%) might occur. Syncope (0.8%) may happen. Acute renal failure could develop. Oliguria might occur. Anuria may happen. Uremia could develop. Progressive azotemia might occur. Renal dysfunction may happen. Muscle spasms could occur. You might feel restlessness. Erythema multiforme including Stevens-Johnson Syndrome may develop. Exfoliative dermatitis including toxic epidermal necrolysis could occur. Alopecia might happen. Purpura may develop. Photosensitivity could occur. Urticaria might happen. Necrotizing angiitis may develop. Respiratory distress including pneumonitis and pulmonary edema could occur. Anaphylactic reactions might happen. Acute myopia may develop. Secondary angle-closure glaucoma could occur. Warnings when pregnancy is detected, discontinue ZESTORETIC as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus angioedema, including laryngeal edema may occur at any time during treatment with angiotensin-converting enzyme inhibitors, including ZESTORETIC patients should be advised and told to report immediately any signs or symptoms suggesting angioedema (swelling of face, extremities, eyes, lips, tongue, difficulty in swallowing or breathing) and to take no more drug until they have consulted with the prescribing physician patients should be cautioned to report lightheadedness especially during the first few days of therapy if actual syncope occurs, the patients should be told to discontinue the drug until they have consulted with the prescribing physician excessive perspiration and dehydration may lead to an excessive fall in blood pressure because of reduction in fluid volume patients should be told not to use salt substitutes containing potassium without consulting their physician patients should be told to report promptly any indication of infection (e.g., sore throat, fever) which may be a sign of leukopenia/neutropenia female patients of childbearing age should be told about the consequences of exposure to ZESTORETIC during pregnancy patients should be asked to report pregnancies to their physicians as soon as possible instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening Pregnancy & Lactation it is not known whether lisinopril is excreted in human milk a decision should be made whether to discontinue nursing and/or discontinue ZESTORETIC, taking into account the importance of the drug to the mother Side Effects dizziness (7.5%) headache (5.2%) cough (3.9%) fatigue (3.7%) orthostatic effects (3.2%) diarrhea (2.5%) nausea (2.2%) upper respiratory infection (2.2%) muscle cramps (2.0%) asthenia (1.8%) paresthesia (1.5%) hypotension (1.4%) vomiting (1.4%) dyspepsia (1.3%) rash (1.2%) impotence (1.2%) chest pain abdominal pain syncope chest discomfort fever trauma virus infection palpitation orthostatic hypotension gastrointestinal cramps dry mouth constipation heartburn back pain shoulder pain knee pain back strain myalgia foot pain decreased libido vertigo depression somnolence common cold nasal congestion influenza bronchitis pharyngeal pain dyspnea pulmonary congestion chronic sinusitis allergic rhinitis pharyngeal discomfort flushing pruritus skin inflammation diaphoresis cutaneous pseudolymphoma blurred vision tinnitus otalgia urinary tract infection angioedema of the face, extremities, lips, tongue, glottis and/or larynx intestinal angioedema hypotension (1.4%) orthostatic hypotension (0.5%) syncope (0.8%) acute renal failure oliguria anuria uremia progressive azotemia renal dysfunction muscle spasm restlessness erythema multiforme including Stevens-Johnson Syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia purpura photosensitivity urticaria necrotizing angiitis respiratory distress including pneumonitis and pulmonary edema anaphylactic reactions acute myopia secondary angle-closure glaucoma
Amiloride Hydrochloride and Hydrochlorothiazide Rx tablet Teva Pharmaceuticals USA, Inc.	Popularity – score 0 out of 100 (least-viewed drug)	23 warnings	1 pregnancy and lactation warnings	91 side effects	Trend: was flat over the year; peak in Aug.
Amiloride Hydrochloride and Hydrochlorothiazide® · First marketed 1989 · Label last revised December 27, 2022View full label details → Warnings Amiloride and hydrochlorothiazide may cause hyperkalemia, which means your serum potassium levels could exceed 5.5 mEq per liter. If you do not have renal impairment or diabetes mellitus, the risk of hyperkalemia with this combination product is about 1 to 2 percent. This risk increases if you have renal impairment or diabetes mellitus, even if you do not have recognized diabetic nephropathy. It is essential for your healthcare provider to monitor your serum potassium levels carefully if you are receiving amiloride hydrochloride and hydrochlorothiazide. Monitoring your serum potassium level is important because mild hyperkalemia typically does not show abnormal ECG changes. If you experience hyperkalemia while taking amiloride and hydrochlorothiazide, your healthcare provider should discontinue the drug immediately. If your serum potassium level exceeds 6.5 mEq per liter, active measures should be taken to reduce it. If you have diabetes, it is best to avoid amiloride and hydrochlorothiazide if possible. If you do use it, your serum electrolytes and renal function must be monitored frequently. You should discontinue amiloride and hydrochlorothiazide at least three days before undergoing glucose tolerance testing. Your healthcare provider should only initiate antikaliuretic therapy with caution if you are severely ill and at risk for respiratory or metabolic acidosis. Frequent monitoring of your acid-base balance is necessary if you have cardiopulmonary disease or poorly controlled diabetes. Sensitivity reactions may occur with or without a history of allergy or bronchial asthma if you are receiving thiazides. There have been reports of exacerbation or activation of systemic lupus erythematosus associated with thiazide use. If you have pre-existing severe liver disease, careful monitoring of your serum electrolyte and BUN levels is important. If you have renal disease, diuretics may lead to azotemia. If renal impairment becomes evident, your healthcare provider should discontinue amiloride and hydrochlorothiazide. You should be observed for clinical signs of fluid or electrolyte imbalance. Warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting. Hyponatremia and hypochloremia may occur during your use of thiazides and other diuretics. Hypokalemia may develop during thiazide therapy, especially with brisk diuresis, in the presence of severe cirrhosis, during concomitant use of corticosteroids or ACTH, or after prolonged therapy. Hypokalemia may lead to cardiac arrhythmia and can also increase the heart's sensitivity to the toxic effects of digitalis. You may experience increases in cholesterol and triglyceride levels associated with thiazide diuretic therapy. There is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults. Pregnancy & Lactation You should decide whether to stop nursing or to discontinue the medication, considering how important the medication is for you. Side Effects You may experience hyperkalemia (serum potassium levels greater than 5.5 mEq per liter). Nausea or loss of appetite may occur. You might feel abdominal pain. Flatulence can happen. Headaches may arise. You could feel weakness. Fatigue or tiredness may be present. You might experience malaise. Chest pain is a possible side effect. Back pain may occur. You could experience syncope. Arrhythmia may happen. Tachycardia is a potential side effect. Digitalis toxicity could occur. You might experience orthostatic hypotension. Angina pectoris may be a concern. Diarrhea can happen. You might feel gastrointestinal pain. Constipation may occur. GI bleeding is a serious side effect to be aware of. You may experience GI disturbance. Changes in appetite could happen. You might feel abdominal fullness. Hiccups can occur. Increased thirst may be experienced. Vomiting is a possible side effect. Loss of appetite may occur. Flatulence can happen. Elevated serum potassium levels (> 5.5 mEq per liter) may occur. Gout is a potential side effect. Dehydration may happen. You could experience symptomatic hyponatremia. Leg aches may occur. Muscle cramps or spasms can happen. You might feel joint pain. Dizziness is a possible side effect. Paresthesia or numbness may occur. Stupor is a serious side effect to be aware of. You might experience vertigo. Insomnia can happen. Nervousness may occur. Depression is a potential side effect. You might feel sleepiness. Mental confusion may occur. Dyspnea is a possible side effect. You might develop a rash. Pruritus can happen. Flushing may occur. Diaphoresis is a potential side effect. Erythema multiforme, including Stevens-Johnson syndrome, is a serious concern. Exfoliative dermatitis, including toxic epidermal necrolysis, may occur. Alopecia can happen. You might experience a bad taste. Visual disturbances may occur. Nasal congestion is a possible side effect. Impotence may happen. Nocturia can occur. Dysuria may be experienced. Incontinence is a potential side effect. Renal dysfunction, including renal failure, is a serious concern. Gynecomastia may occur. Pancreatitis is a potential side effect. Jaundice (intrahepatic cholestatic jaundice) may happen. Sialadenitis can occur. Cramping may be experienced. Gastric irritation is a possible side effect. Aplastic anemia is a serious concern. Neutropenia may occur. You might experience tremors. Decreased libido can happen. Shortness of breath is a possible side effect. Cough may occur. Increased intraocular pressure is a potential concern. Tinnitus may happen. Bladder spasms can occur. Polyuria is a possible side effect. You might experience urinary frequency. Anaphylactic reactions are a serious concern. Necrotizing angiitis (vasculitis, cutaneous vasculitis) may occur. Respiratory distress, including pneumonitis and pulmonary edema, is a serious concern. Photosensitivity may happen. Fever is a possible side effect. Urticaria can occur. Purpura may be experienced. Electrolyte imbalance is a potential concern. Hyperglycemia may occur. Glycosuria is a possible side effect. Hyperuricemia may happen. Restlessness can occur. You might experience transient blurred vision. Xanthopsia is a potential side effect. Warnings amiloride and hydrochlorothiazide may cause hyperkalemia (serum potassium levels greater than 5.5 mEq per liter) the risk of hyperkalemia with this combination product is about 1 to 2 percent in patients without renal impairment or diabetes mellitus this risk is higher in patients with renal impairment or diabetes mellitus (even without recognized diabetic nephropathy) it is essential to monitor serum potassium levels carefully in any patient receiving amiloride hydrochloride and hydrochlorothiazide monitoring of the serum potassium level is essential because mild hyperkalemia is not usually associated with an abnormal ECG if hyperkalemia occurs in patients taking amiloride and hydrochlorothiazide, the drug should be discontinued immediately if the serum potassium level exceeds 6.5 mEq per liter, active measures should be taken to reduce it amiloride and hydrochlorothiazide should be avoided, if possible, in diabetic patients and, if it is used, serum electrolytes and renal function must be monitored frequently amiloride and hydrochlorothiazide should be discontinued at least three days before glucose tolerance testing antikaliuretic therapy should be instituted only with caution in severely ill patients in whom respiratory or metabolic acidosis may occur frequent monitoring of acid-base balance is necessary in patients with cardiopulmonary disease or poorly controlled diabetes sensitivity reactions may occur with or without a history of allergy or bronchial asthma in patients receiving thiazides the possibility of exacerbation or activation of systemic lupus erythematosus has been reported with the use of thiazides careful monitoring of serum electrolyte and BUN levels is important in patients with pre-existing severe liver disease in patients with renal disease, diuretics may precipitate azotemia if renal impairment becomes evident, amiloride and hydrochlorothiazide should be discontinued patients should be observed for clinical signs of fluid or electrolytes imbalance warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting hyponatremia and hypochloremia may occur during the use of thiazides and other diuretics hypokalemia may develop during thiazide therapy, especially with brisk diuresis, when severe cirrhosis is present, during concomitant use of corticosteroids or ACTH, or after prolonged therapy hypokalemia may cause cardiac arrhythmia and may also sensitize or exaggerate the response of the heart to the toxic effects of digitalis increases in cholesterol and triglyceride levels may be associated with thiazide diuretic therapy there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults Pregnancy & Lactation a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother Side Effects hyperkalemia (serum potassium levels greater than 5.5 mEq per liter) nausea/anorexia abdominal pain flatulence headache weakness fatigue/tiredness malaise chest pain back pain syncope arrhythmia tachycardia digitalis toxicity orthostatic hypotension angina pectoris diarrhea gastrointestinal pain constipation GI bleeding GI disturbance appetite changes abdominal fullness hiccups thirst vomiting anorexia flatulence elevated serum potassium levels (> 5.5 mEq per liter) gout dehydration symptomatic hyponatremia leg ache muscle cramps/spasm joint pain dizziness paresthesia/numbness stupor vertigo insomnia nervousness depression sleepiness mental confusion dyspnea rash pruritus flushing diaphoresis erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia bad taste visual disturbance nasal congestion impotence nocturia dysuria incontinence renal dysfunction including renal failure gynecomastia pancreatitis jaundice (intrahepatic cholestatic jaundice) sialadenitis cramping gastric irritation aplastic anemia neutropenia tremors decreased libido shortness of breath cough increased intraocular pressure tinnitus bladder spasms polyuria urinary frequency anaphylactic reactions necrotizing angiitis (vasculitis, cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia restlessness transient blurred vision xanthopsia
Amlodipine, Valsartan and Hydrochlorothiazide Rx tablet, film coated Macleods Pharmaceuticals Limited	Popularity – score 0 out of 100 (least-viewed drug)	8 warnings	8 pregnancy and lactation warnings	14 side effects	Trend: was flat over 11 months.
Amlodipine, Valsartan and Hydrochlorothiazide® · First marketed 2025 · Label last revised January 9, 2025View full label details → Warnings If you find out you are pregnant, please stop taking amlodipine, valsartan, and hydrochlorothiazide tablets as soon as possible. Be aware that medications affecting the renin-angiotensin system can harm the developing fetus and may lead to serious complications. Make sure to correct any volume depletion before starting treatment. You may experience increased angina or a higher risk of myocardial infarction. Your healthcare provider should monitor your renal function and potassium levels if you are at risk. There is a possibility of exacerbating or activating systemic lupus erythematosus. Keep an eye out for any signs of fluid or electrolyte imbalance. Be cautious of acute angle-closure glaucoma. Pregnancy & Lactation Amlodipine, valsartan, and hydrochlorothiazide tablets can cause harm to the fetus if you are pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase the risk of complications for both the fetus and newborn. If you find out you are pregnant, please stop taking amlodipine, valsartan, and hydrochlorothiazide tablets as soon as possible. Thiazides can cross the placenta, and the levels in the umbilical vein can be similar to those in your bloodstream. Taking thiazides during pregnancy may increase the risk of jaundice or low platelet counts in the fetus or newborn. These medications should not be used to manage high blood pressure in pregnant women. Oligohydramnios in pregnant women using drugs that affect the renin-angiotensin system during the second and third trimesters can lead to reduced kidney function in the fetus, resulting in anuria, kidney failure, underdeveloped lungs, skeletal deformities, low blood pressure, and even death. Your healthcare provider should closely monitor newborns who were exposed in utero to amlodipine, valsartan, and hydrochlorothiazide tablets for signs of low blood pressure, reduced urine output, and high potassium levels. Side Effects You may experience dizziness. You might notice peripheral edema. Headaches can occur. Dyspepsia may be a possibility. Fatigue is something to watch for. Muscle spasms could happen. You may feel back pain. Nausea is a potential side effect. Watch for signs of nasopharyngitis. Hypotension may occur. You could experience increased angina and/or myocardial infarction. There may be an exacerbation or activation of systemic lupus erythematosus. Be aware of signs of fluid or electrolyte imbalance. Acute angle-closure glaucoma is a serious condition to monitor. Warnings when pregnancy is detected, discontinue amlodipine, valsartan and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume depletion prior to initiation increased angina and/or myocardial infarction monitor renal function and potassium in susceptible patients exacerbation or activation of systemic lupus erythematosus observe for signs of fluid or electrolyte imbalance acute angle-closure glaucoma Pregnancy & Lactation amlodipine, valsartan and hydrochlorothiazide tablets can cause fetal harm when administered to a pregnant woman use of drugs that act on the reninangiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue amlodipine, valsartan and hydrochlorothiazide tablets as soon as possible thiazides can cross the placenta, and concentrations reached in the umbilical vein approach those in the maternal plasma use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia these drugs should not be used to treat hypertension in pregnant women oligohydramnios in pregnant women who use drugs affecting the renin-angiotensin system in the second and third trimesters of pregnancy can result in reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension and death closely observe neonates with histories of in utero exposure to amlodipine, valsartan and hydrochlorothiazide tablets for hypotension, oliguria, and hyperkalemia Side Effects dizziness peripheral edema headache dyspepsia fatigue muscle spasms back pain nausea nasopharyngitis hypotension increased angina and/or myocardial infarction exacerbation or activation of systemic lupus erythematosus signs of fluid or electrolyte imbalance acute angle-closure glaucoma
Amlodipine, Valsartan and Hydrochlorothiazide Rx tablet, film coated Lupin Pharmaceuticals, Inc.	Popularity – score 0 out of 100 (least-viewed drug)	8 warnings	9 pregnancy and lactation warnings	13 side effects	Trend: was flat over 11 months.
Amlodipine, Valsartan and Hydrochlorothiazide® · First marketed 2015 · Label last revised December 14, 2023View full label details → Warnings If you find out you are pregnant, please stop taking amlodipine, valsartan, and hydrochlorothiazide as soon as possible. Be aware that medications affecting the renin-angiotensin system can harm the developing fetus and may lead to serious complications. Make sure to correct any volume depletion before starting treatment. You may experience increased angina or a higher risk of myocardial infarction. Your healthcare provider should monitor your renal function and potassium levels if you are at risk. There is a possibility of exacerbating or activating systemic lupus erythematosus. Keep an eye out for any signs of fluid or electrolyte imbalance. Be cautious of acute angle-closure glaucoma. Pregnancy & Lactation Amlodipine, valsartan, and hydrochlorothiazide can cause harm to your fetus if you are pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of your pregnancy can reduce your fetus's renal function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please discontinue amlodipine, valsartan, and hydrochlorothiazide as soon as possible. Having high blood pressure during pregnancy raises your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for your fetus of intrauterine growth restriction and intrauterine death. Oligohydramnios in pregnant women using medications that affect the renin-angiotensin system during the second and third trimesters can lead to reduced fetal renal function, which may result in anuria, renal failure, fetal lung hypoplasia, skeletal deformations (including skull hypoplasia), hypotension, and even death. Using thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia. These medications should not be used to treat high blood pressure in pregnant women. The use of HCTZ for other conditions during pregnancy should be avoided. Side Effects You may experience dizziness. You might notice peripheral edema. Headaches can occur. Dyspepsia may be a possibility. Fatigue is something to watch for. Muscle spasms could happen. You may feel back pain. Nausea is a potential side effect. Nasopharyngitis might develop. You could experience hypotension. There may be an increase in angina and/or myocardial infarction. Exacerbation or activation of systemic lupus erythematosus is possible. Acute angle-closure glaucoma may occur. Warnings when pregnancy is detected, discontinue amlodipine, valsartan and hydrochlorothiazide as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume depletion prior to initiation increased angina and/or myocardial infarction monitor renal function and potassium in susceptible patients exacerbation or activation of systemic lupus erythematosus observe for signs of fluid or electrolyte imbalance acute angle-closure glaucoma Pregnancy & Lactation amlodipine, valsartan and hydrochlorothiazide can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue amlodipine, valsartan and hydrochlorothiazide as soon as possible hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death oligohydramnios in pregnant women who use drugs affecting the renin-angiotensin system in the second and third trimesters of pregnancy can result in reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension and death use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia these drugs should not be used to treat hypertension in pregnant women the use of HCTZ for other indications in pregnancy should be avoided Side Effects dizziness peripheral edema headache dyspepsia fatigue muscle spasms back pain nausea nasopharyngitis hypotension increased angina and/or myocardial infarction exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma
Amlodipine, Valsartan and Hydrochlorothiazide Rx tablet, film coated Aurobindo Pharma Limited	Popularity – score 0 out of 100 (least-viewed drug)	8 warnings	9 pregnancy and lactation warnings	12 side effects	Trend: was flat over 11 months.
Amlodipine, Valsartan and Hydrochlorothiazide® · First marketed 2017 · Label last revised May 17, 2024View full label details → Warnings If you find out you are pregnant, please stop taking amlodipine, valsartan, and hydrochlorothiazide as soon as possible. Be aware that medications affecting the renin-angiotensin system can harm the developing fetus and may lead to serious complications. Make sure to correct any volume depletion before starting treatment. You may experience increased angina or a higher risk of myocardial infarction. Your healthcare provider should monitor your renal function and potassium levels if you are at risk. There is a possibility of exacerbating or activating systemic lupus erythematosus. Keep an eye out for any signs of fluid or electrolyte imbalance. Be cautious of acute angle-closure glaucoma. Pregnancy & Lactation Amlodipine, valsartan, and hydrochlorothiazide can cause harm to your fetus if you are pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of your pregnancy can reduce your fetus's renal function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please discontinue amlodipine, valsartan, and hydrochlorothiazide as soon as possible. Having high blood pressure during pregnancy raises your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for your fetus of intrauterine growth restriction and intrauterine death. Oligohydramnios in pregnant women using medications that affect the renin-angiotensin system during the second and third trimesters can lead to reduced renal function in the fetus, resulting in anuria, renal failure, fetal lung hypoplasia, skeletal deformations such as skull hypoplasia, hypotension, and even death. Using thiazides during pregnancy is linked to a risk of fetal or neonatal jaundice or thrombocytopenia. These medications should not be used to treat high blood pressure in pregnant women. It is not recommended to breastfeed while being treated with amlodipine, valsartan, and hydrochlorothiazide. Side Effects You may experience dizziness. You might notice peripheral edema. Headaches can occur. Dyspepsia may be a possibility. Fatigue is something to watch for. Muscle spasms could happen. You may feel back pain. Nausea is a potential side effect. Hypotension might occur. Be aware of increased angina and/or myocardial infarction. There may be an exacerbation or activation of systemic lupus erythematosus. Acute angle-closure glaucoma is a serious condition to monitor. Warnings when pregnancy is detected, discontinue amlodipine, valsartan and hydrochlorothiazide as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume depletion prior to initiation increased angina and/or myocardial infarction monitor renal function and potassium in susceptible patients exacerbation or activation of systemic lupus erythematosus observe for signs of fluid or electrolyte imbalance acute angle-closure glaucoma Pregnancy & Lactation amlodipine, valsartan and hydrochlorothiazide can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue amlodipine, valsartan and hydrochlorothiazide as soon as possible hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death oligohydramnios in pregnant women who use drugs affecting the renin-angiotensin system in the second and third trimesters of pregnancy can result in reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension and death use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia these drugs should not be used to treat hypertension in pregnant women breastfeeding is not recommended during treatment with amlodipine, valsartan and hydrochlorothiazide Side Effects dizziness peripheral edema headache dyspepsia fatigue muscle spasms back pain nausea hypotension increased angina and/or myocardial infarction exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma
Amlodipine, Valsartan, Hydrochlorothiazide (amlodipine besylate valsartan hydrochlorothiazide) Rx tablet, film coated Strides Pharma Science Limited	Popularity – score 0 out of 100 (least-viewed drug)	8 warnings	9 pregnancy and lactation warnings	13 side effects	Trend: was flat over 11 months.
Amlodipine, Valsartan, Hydrochlorothiazide® · First marketed 2022 · Label last revised April 10, 2025View full label details → Warnings If you find out you are pregnant, please stop taking amlodipine/valsartan/hydrochlorothiazide as soon as possible. Be aware that medications affecting the renin-angiotensin system can harm the developing fetus and may lead to serious complications. Make sure to correct any volume depletion before starting treatment. You may experience increased angina or a higher risk of myocardial infarction. Your healthcare provider should monitor your renal function and potassium levels if you are at risk. There is a possibility of exacerbating or activating systemic lupus erythematosus. Keep an eye out for any signs of fluid or electrolyte imbalance. Be cautious of acute angle-closure glaucoma. Pregnancy & Lactation Amlodipine/valsartan/hydrochlorothiazide can cause harm to the fetus if you are pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase the risk of complications for both the fetus and newborn. If you find out you are pregnant, please stop taking Amlodipine/valsartan/hydrochlorothiazide as soon as possible. Oligohydramnios in pregnant women using medications that affect the renin-angiotensin system during the second and third trimesters can lead to reduced fetal kidney function, resulting in anuria and kidney failure, as well as fetal lung underdevelopment, skeletal deformities (including skull underdevelopment), low blood pressure, and even death. Thiazides can cross the placenta, and the levels in the umbilical vein can be similar to those in your bloodstream. Using thiazides during pregnancy may increase the risk of jaundice or low platelet counts in the fetus or newborn. These medications should not be used to treat high blood pressure in pregnant women. It is best to avoid using HCTZ for other conditions (like heart disease) during pregnancy. If you are breastfeeding, please be advised that it is not recommended to continue while taking Amlodipine/valsartan/hydrochlorothiazide. Side Effects You may experience dizziness. You might notice peripheral edema. Headaches can occur. Dyspepsia may be a possibility. Fatigue is something to watch for. Muscle spasms could happen. You may feel back pain. Nausea is a potential side effect. Nasopharyngitis might develop. You could experience hypotension. There is a risk of increased angina and/or myocardial infarction. Be aware of the possibility of exacerbation or activation of systemic lupus erythematosus. Acute angle-closure glaucoma is a serious condition to monitor. Warnings when pregnancy is detected, discontinue amlodipine/valsartan/hydrochlorothiazide as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume depletion prior to initiation increased angina and/or myocardial infarction monitor renal function and potassium in susceptible patients exacerbation or activation of systemic lupus erythematosus observe for signs of fluid or electrolyte imbalance acute angle-closure glaucoma Pregnancy & Lactation Amlodipine/valsartan/hydrochlorothiazide can cause fetal harm when administered to a pregnant woman Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death When pregnancy is detected, discontinue Amlodipine/valsartan/hydrochlorothiazide as soon as possible Oligohydramnios in pregnant women who use drugs affecting the renin-angiotensin system in the second and third trimesters of pregnancy can result in reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension and death Thiazides can cross the placenta, and concentrations reached in the umbilical vein approach those in the maternal plasma Use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia These drugs should not be used to treat hypertension in pregnant women The use of HCTZ for other indications (e.g., heart disease) in pregnancy should be avoided Advise a nursing woman that breastfeeding is not recommended during treatment with Amlodipine/valsartan/hydrochlorothiazide Side Effects dizziness peripheral edema headache dyspepsia fatigue muscle spasms back pain nausea nasopharyngitis hypotension increased angina and/or myocardial infarction exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma
Atacand Hct (candesartan cilexetil and hydrochlorothiazide) Rx tablet ANI Pharmaceuticals, Inc.	Popularity – score 0 out of 100 (least-viewed drug)	16 warnings	1 pregnancy and lactation warnings	59 side effects	Trend: fell 22% over the year; peaks in Jul, Aug, Nov.
Atacand Hct® · First marketed 2018 · Label last revised December 22, 2025View full label details → Warnings If you find out you are pregnant, please stop taking ATACAND HCT as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially causing injury or even death. If you experience symptomatic hypotension, you may need to temporarily reduce your dose of ATACAND HCT or receive volume repletion. Make sure to correct any volume and/or salt depletion before starting therapy with ATACAND HCT. If you have heart failure, ATACAND HCT may lead to excessive hypotension, which could result in oliguria, azotemia, and, in rare cases, acute renal failure and death. Your healthcare provider will periodically check your renal function while you are on ATACAND HCT. If you experience a significant decrease in renal function while taking ATACAND HCT, your healthcare provider may consider withholding or stopping the therapy. Your healthcare provider will also monitor your serum electrolytes periodically. Be aware that lightheadedness can occur, especially during the first few days of therapy with ATACAND HCT, and make sure to report this to your prescribing physician. If you experience syncope, please stop taking ATACAND HCT until you have consulted with your physician. It's important to know that inadequate fluid intake, excessive sweating, diarrhea, or vomiting can lead to a significant drop in blood pressure, which may cause lightheadedness or syncope. If you are taking ATACAND HCT, do not use potassium supplements, salt substitutes containing potassium, or other medications that may raise your serum potassium levels without first consulting your prescribing physician. If you are taking hydrochlorothiazide, be sure to protect your skin from the sun and have regular skin cancer screenings. Hypersensitivity reactions to hydrochlorothiazide can occur in patients with or without a history of allergies or bronchial asthma, but they are more common in those with such a history. If you experience oliguria or hypotension, focus on supporting your blood pressure and renal perfusion. The safety and effectiveness of this medication in children have not been established. Pregnancy & Lactation You should decide whether to continue nursing or stop the medication, considering how important the medication is for you. Side Effects You may experience an upper respiratory tract infection (3.6% vs 3.0%). Back pain may occur (3.3% vs 2.4%). You might have influenza-like symptoms (2.5% vs 1.9%). Dizziness could be a side effect (2.9% vs 1.2%). Be aware of abnormal hepatic function. Hepatitis is a potential concern. Neutropenia may develop. You could experience leukopenia. Agranulocytosis is a possible side effect. Angioedema may occur. Hyperkalemia is something to watch for. Hyponatremia could be a risk. Cough may be experienced. Pruritus might occur. You may notice a rash. Urticaria could develop. Pancreatitis is a potential side effect. Jaundice (intrahepatic cholestatic jaundice) may occur. Sialadenitis is a possible concern. Cramping might happen. You could experience constipation. Gastric irritation may occur. Anorexia is a potential side effect. Aplastic anemia is a serious concern. Agranulocytosis may develop. Leukopenia could occur. Hemolytic anemia is a potential risk. Thrombocytopenia may happen. Be aware of anaphylactic reactions. Necrotizing angiitis (vasculitis and cutaneous vasculitis) is a possible side effect. Respiratory distress, including pneumonitis and pulmonary edema, may occur. Photosensitivity could be a concern. Urticaria might develop. Purpura may occur. Muscle spasms could happen. Hydrochlorothiazide is associated with an increased risk of non-melanoma skin cancer. Erythema multiforme, including Stevens-Johnson syndrome, is a potential risk. Exfoliative dermatitis, including toxic epidermal necrolysis, may occur. Alopecia could happen. You might experience transient blurred vision. Xanthopsia may occur. Impotence is a possible side effect. Symptomatic hypotension could develop. Oliguria may be a concern. Azotemia is a potential risk. Acute renal failure could occur. Hyperkalemia is something to watch for. Hypokalemia may develop. Hyponatremia could be a risk. Acute transient myopia might occur. Acute angle-closure glaucoma is a potential concern. Hypersensitivity reactions to hydrochlorothiazide may happen. Altered glucose tolerance could be a side effect. You may have elevated serum levels of cholesterol and triglycerides. Elevated serum uric acid levels may occur. Hyperuricemia is a potential risk. Gout could develop. Elevation of serum calcium may happen. Exacerbation or activation of systemic lupus erythematosus is a possible concern. Warnings when pregnancy is detected, discontinue ATACAND HCT as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus patients with symptomatic hypotension may require temporarily reducing the dose of ATACAND HCT or volume repletion volume and/or salt depletion should be corrected before initiating therapy with ATACAND HCT in patients with heart failure, ATACAND HCT may cause excessive hypotension, which may lead to oliguria, azotemia, and (rarely) with acute renal failure and death monitor renal function periodically in patients treated with ATACAND HCT consider withholding or discontinuing therapy in patients who develop a clinically significant decrease in renal function on ATACAND HCT monitor serum electrolytes periodically tell patients receiving ATACAND HCT that lightheadedness can occur, especially during the first days of therapy, and that it should be reported to the prescribing physician tell patients that if syncope occurs, discontinue ATACAND HCT until the physician has been consulted tell all patients that inadequate fluid intake, excessive perspiration, diarrhea, or vomiting can lead to an excessive fall in blood pressure, with the same consequences of lightheadedness and possible syncope tell patients receiving ATACAND HCT not to use potassium supplements, salt substitutes containing potassium, or other drugs that may increase serum potassium levels without consulting the prescribing physician instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening hypersensitivity reactions to hydrochlorothiazide may occur in patients with or without a history of allergy or bronchial asthma, but are more likely in patients with such a history if oliguria or hypotension occurs, direct attention toward support of blood pressure and renal perfusion safety and effectiveness in pediatric patients have not been established Pregnancy & Lactation a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother Side Effects upper respiratory tract infection (3.6% vs 3.0%) back pain (3.3% vs 2.4%) influenza-like symptoms (2.5% vs 1.9%) dizziness (2.9% vs 1.2%) abnormal hepatic function hepatitis neutropenia leukopenia agranulocytosis angioedema hyperkalemia hyponatremia cough pruritus rash urticaria pancreatitis jaundice (intrahepatic cholestatic jaundice) sialadenitis cramping constipation gastric irritation anorexia aplastic anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity urticaria purpura muscle spasm hydrochlorothiazide is associated with an increased risk of non-melanoma skin cancer erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia impotence symptomatic hypotension oliguria azotemia acute renal failure hyperkalemia hypokalemia hyponatremia acute transient myopia acute angle-closure glaucoma hypersensitivity reactions to hydrochlorothiazide altered glucose tolerance elevated serum levels of cholesterol and triglycerides elevated serum uric acid level hyperuricemia gout elevation of serum calcium exacerbation or activation of systemic lupus erythematosus
Benazepril Hydrochloride and Hydrochlorothiazide Rx tablet Advagen Pharma Ltd	Popularity – score 0 out of 100 (least-viewed drug)	27 warnings	1 pregnancy and lactation warnings	92 side effects	Trend: was flat over the year; peaks in Aug, Oct, Dec; bumpy overall.
Benazepril Hydrochloride and Hydrochlorothiazide® · First marketed 2024 · Label last revised January 7, 2026View full label details → Warnings If you find out you are pregnant, please stop taking Benazepril HCl and Hydrochlorothiazide as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. Angioedema affecting the face, extremities, lips, tongue, glottis, and larynx has been reported in patients treated with angiotensin-converting enzyme inhibitors. If you experience laryngeal stridor or angioedema of the face, tongue, or glottis, stop taking Benazepril HCl and Hydrochlorothiazide immediately and seek appropriate treatment. Black patients taking ACE inhibitors may have a higher risk of experiencing angioedema compared to nonblack patients. If you are taking both an ACE inhibitor and an mTOR inhibitor, you may be at an increased risk for angioedema. Intestinal angioedema has been reported in patients using ACE inhibitors. If you have allergies or asthma, you may be more likely to experience hypersensitivity reactions to hydrochlorothiazide. Benazepril HCl and Hydrochlorothiazide can lead to symptomatic hypotension. You are more likely to experience symptomatic hypotension if you have been depleted of volume and/or salt. Use Benazepril HCl and Hydrochlorothiazide cautiously if you are also taking other antihypertensive medications. In patients with congestive heart failure, ACE inhibitor therapy may lead to excessive hypotension. Your healthcare provider should periodically monitor your renal function while you are being treated with Benazepril HCl and Hydrochlorothiazide. If you experience a significant decrease in renal function while on Benazepril HCl and Hydrochlorothiazide, your healthcare provider may consider withholding or discontinuing therapy. If you have collagen vascular disease, your healthcare provider may want to monitor your white blood cell counts. Please report any signs or symptoms of angioedema to your healthcare provider immediately. If you are a female of childbearing age, it’s important to understand the risks of using Benazepril HCl and Hydrochlorothiazide during pregnancy. Be aware that lightheadedness can occur while taking Benazepril HCl and Hydrochlorothiazide. If you experience syncope, please discontinue Benazepril HCl and Hydrochlorothiazide and consult your physician. Do not use potassium supplements or salt substitutes containing potassium without first consulting your prescribing physician. Promptly report any signs of infection, as this could indicate neutropenia. If you are taking hydrochlorothiazide, protect your skin from the sun and have regular skin cancer screenings. If you experience oliguria or hypotension, focus on supporting your blood pressure and renal perfusion. The safety and effectiveness of this medication in children have not been established. The safety and effectiveness of Benazepril HCl and Hydrochlorothiazide in patients with severe renal impairment have not been established. No adjustment of the initial dose is needed for patients with mild to moderate hepatic impairment. Minor changes in fluid and electrolyte balance may lead to hepatic coma in patients with impaired liver function or progressive liver disease. Pregnancy & Lactation You should decide whether to continue nursing or to stop taking Benazepril HCl and Hydrochlorothiazide, considering how important the medication is for you. Side Effects You may experience dizziness. Fatigue can occur. You might notice postural dizziness. Headaches are possible. Coughing may happen. Hypertonia could be a side effect. You might feel vertigo. Nausea can occur. Impotence may be experienced. Somnolence is a possibility. Palpitations might happen. Flushing can occur. Vomiting may be a side effect. Diarrhea is possible. Dyspepsia could occur. You might experience anorexia. Constipation can happen. Insomnia may be experienced. Nervousness is a possibility. Paresthesia might occur. You may notice a decrease in libido. Dry mouth can happen. Taste perversion may occur. Tinnitus is possible. A rash might develop. Sweating can occur. You may experience urinary frequency. Arthralgia might happen. Myalgia is a possibility. Asthenia could occur. Pain may be experienced. Syncope is a possibility. You might have a peripheral vascular disorder. Tachycardia can occur. Infection may happen. Back pain is possible. Flu syndrome might occur. You may experience fever. Chills can happen. Neck pain might be experienced. Photosensitivity is a possibility. Pruritus may occur. Gastroenteritis could happen. Flatulence might occur. You may have a tooth disorder. Hypesthesia is possible. Abnormal vision may occur. You might experience abnormal dreams. A retinal disorder could happen. Upper respiratory infection may occur. Epistaxis is a possibility. Bronchitis might develop. Rhinitis can occur. Sinusitis may happen. Voice alteration is possible. Conjunctivitis might occur. Arthritis may be experienced. You might have a urinary tract infection. Alopecia could happen. Acute renal failure is a possibility. Anaphylactoid reactions may occur. Hypotension might happen. Acute myopia could be experienced. Secondary angle-closure glaucoma is a possibility. Stevens-Johnson syndrome may occur. Pancreatitis might happen. Hemolytic anemia could occur. Pemphigus is a possibility. Thrombocytopenia may happen. Eosinophilic pneumonitis might occur. Jaundice is possible. Sialadenitis may occur. Gastric irritation could happen. Cramping might be experienced. Lightheadedness is a possibility. Transient blurred vision may occur. You might feel weakness. Restlessness can happen. Muscle spasms may occur. Aplastic anemia is a possibility. Agranulocytosis might happen. Leukopenia could occur. Neutropenia may be experienced. Hyperglycemia is a possibility. Glycosuria might occur. Hyperuricemia may happen. Pyrexia is possible. Asthenia could occur. Parathyroid gland changes with hypercalcemia and hypophosphatemia may happen. Anaphylactoid reactions during desensitization could occur. Anaphylactoid reactions during membrane exposure may happen. Exacerbation or activation of systemic lupus erythematosus is a possibility. Warnings when pregnancy is detected, discontinue Benazepril HCl and Hydrochlorothiazide as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus angioedema of the face, extremities, lips, tongue, glottis, and larynx has been reported in patients treated with angiotensin-converting enzyme inhibitors if laryngeal stridor or angioedema of the face, tongue, or glottis occurs, treatment with Benazepril HCl and Hydrochlorothiazide should be discontinued and appropriate therapy instituted immediately black patients receiving ACE inhibitors have been reported to have a higher incidence of angioedema compared to nonblacks patients receiving coadministration of ACE inhibitor and mTOR inhibitor may be at increased risk for angioedema intestinal angioedema has been reported in patients treated with ACE inhibitors hypersensitivity reactions to hydrochlorothiazide are more likely in patients with allergy and asthma Benazepril HCl and Hydrochlorothiazide can cause symptomatic hypotension symptomatic hypotension is most likely to occur in patients who have been volume and/or salt depleted Benazepril HCl and Hydrochlorothiazide should be used cautiously in patients receiving concomitant therapy with other antihypertensives in patients with congestive heart failure, ACE inhibitor therapy may cause excessive hypotension monitor renal function periodically in patients treated with Benazepril HCl and Hydrochlorothiazide consider withholding or discontinuing therapy in patients who develop a clinically significant decrease in renal function on Benazepril HCl and Hydrochlorothiazide monitoring of white blood cell counts should be considered in patients with collagen vascular disease patients should be told to report immediately any signs or symptoms suggesting angioedema female patients of childbearing age should be told about the consequences of exposure to Benazepril HCl and Hydrochlorothiazide during pregnancy a patient receiving Benazepril HCl and Hydrochlorothiazide should be cautioned that lightheadedness can occur if syncope occurs, Benazepril HCl and Hydrochlorothiazide should be discontinued until the physician has been consulted a patient receiving Benazepril HCl and Hydrochlorothiazide should be told not to use potassium supplements or salt substitutes containing potassium without consulting the prescribing physician patients should be told to promptly report any indication of infection, which could be a sign of neutropenia instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening if oliguria or hypotension occurs, direct attention toward support of blood pressure and renal perfusion safety and effectiveness in pediatric patients have not been established safety and effectiveness of Benazepril HCl and Hydrochlorothiazide in patients with severe renal impairment have not been established no adjustment of the initial dose is required for patients with mild to moderate hepatic impairment minor alterations of fluid and electrolyte imbalance may precipitate hepatic coma in patients with impaired hepatic function or progressive liver disease Pregnancy & Lactation a decision should be made whether to discontinue nursing or to discontinue Benazepril HCl and Hydrochlorothiazide, taking into account the importance of the drug to the mother Side Effects dizziness fatigue postural dizziness headache cough hypertonia vertigo nausea impotence somnolence palpitations flushing vomiting diarrhea dyspepsia anorexia constipation insomnia nervousness paresthesia libido decrease dry mouth taste perversion tinnitus rash sweating urinary frequency arthralgia myalgia asthenia pain syncope peripheral vascular disorder tachycardia infection back pain flu syndrome fever chills neck pain photosensitivity pruritus gastroenteritis flatulence tooth disorder hypesthesia abnormal vision abnormal dreams retinal disorder upper respiratory infection epistaxis bronchitis rhinitis sinusitis voice alteration conjunctivitis arthritis urinary tract infection alopecia acute renal failure anaphylactoid reactions hypotension acute myopia secondary angle-closure glaucoma Stevens-Johnson syndrome pancreatitis hemolytic anemia pemphigus thrombocytopenia eosinophilic pneumonitis jaundice sialadenitis gastric irritation cramping lightheadedness transient blurred vision weakness restlessness muscle spasm aplastic anemia agranulocytosis leukopenia neutropenia hyperglycemia glycosuria hyperuricemia pyrexia asthenia parathyroid gland changes with hypercalcemia and hypophosphatemia anaphylactoid reactions during desensitization anaphylactoid reactions during membrane exposure exacerbation or activation of systemic lupus erythematosus
Benazepril Hydrochloride and Hydrochlorothiazide Rx tablet, film coated Glenmark Pharmaceuticals Inc. , USA	Popularity – score 0 out of 100 (least-viewed drug)	23 warnings	4 pregnancy and lactation warnings	91 side effects	Trend: was flat over the year; peaks in Aug, Oct, Dec; bumpy overall.
Benazepril Hydrochloride and Hydrochlorothiazide® · First marketed 2004 · Label last revised September 30, 2023View full label details → Warnings If you find out you are pregnant, please stop taking benazepril hydrochloride and hydrochlorothiazide as soon as possible. Medications that directly affect the renin-angiotensin system can harm your developing fetus. If you are taking ACE inhibitors, be aware that you may experience various adverse reactions, some of which can be serious. Angioedema affecting the face, extremities, lips, tongue, glottis, and larynx has been reported in individuals treated with ACE inhibitors. If you experience laryngeal stridor or angioedema of the face, tongue, or glottis, stop taking benazepril hydrochloride and hydrochlorothiazide immediately and seek appropriate treatment. If there is a risk of airway obstruction due to involvement of the tongue, glottis, or larynx, prompt administration of appropriate therapy, such as subcutaneous epinephrine injection 1:1000 (0.3 to 0.5 ml), is necessary. Black patients taking ACE inhibitors have been reported to have a higher incidence of angioedema compared to non-black patients. If you are taking both an ACE inhibitor and an mTOR inhibitor, you may be at an increased risk for angioedema. Intestinal angioedema has been reported in patients treated with ACE inhibitors. Your healthcare provider should periodically monitor your renal function if you are being treated with benazepril hydrochloride and hydrochlorothiazide. If you experience a significant decrease in renal function while on benazepril hydrochloride and hydrochlorothiazide, your healthcare provider may consider withholding or discontinuing your therapy. If you have collagen-vascular disease, especially with impaired renal function, your healthcare provider should consider monitoring your white blood cell counts. If you are taking benazepril hydrochloride and hydrochlorothiazide, please report any signs or symptoms of angioedema to your healthcare provider immediately. If you are a female of childbearing age, it’s important to understand the risks of taking benazepril hydrochloride and hydrochlorothiazide during pregnancy. Be aware that lightheadedness can occur, especially during the first few days of therapy with benazepril hydrochloride and hydrochlorothiazide. If you experience syncope, please discontinue benazepril hydrochloride and hydrochlorothiazide until you have consulted your physician. Do not use potassium supplements or salt substitutes containing potassium without first consulting your prescribing physician. Promptly report any signs of infection, such as a sore throat or fever, as these could indicate neutropenia. If you are taking hydrochlorothiazide, protect your skin from the sun and make sure to undergo regular skin cancer screenings. Hydrochlorothiazide can cause an unusual reaction that may lead to acute transient myopia and acute angle-closure glaucoma. If left untreated, acute angle-closure glaucoma can result in permanent vision loss. If you develop jaundice or significant elevations in hepatic enzymes while taking ACE inhibitors, please discontinue the medication and seek appropriate medical follow-up. Thiazide diuretics may exacerbate or activate systemic lupus erythematosus. Pregnancy & Lactation You should decide whether to continue nursing or to stop taking benazepril hydrochloride and hydrochlorothiazide, considering how important the medication is for you. Only minimal amounts of unchanged benazepril and benazeprilat are found in the breast milk of women who are nursing and taking benazepril. However, thiazides are definitely present in breast milk. Be aware of the potential for serious adverse reactions in nursing infants from hydrochlorothiazide, as well as the unknown effects of benazepril in infants. Side Effects You may experience a cough (1.0%). You might feel dizzy (1.0%). You could have a headache (0.6%). You may feel fatigued (0.6%). Dizziness has been reported in 6.3% of patients. Fatigue has been noted in 5.2% of patients. Postural dizziness has occurred in 3.5% of patients. Headaches have been reported in 3.1% of patients. Coughing has been experienced by 2.1% of patients. Hypertonia has been observed in 1.5% of patients. You might experience vertigo (1.5% of patients). Nausea has been reported in 1.4% of patients. Impotence has occurred in 1.2% of patients. Somnolence has been noted in 1.2% of patients. You may notice palpitations. You might experience flushing. You could have vomiting. You may experience diarrhea. Dyspepsia might occur. You may feel anorexia. You could experience constipation. You might have insomnia. You may feel nervousness. You could experience paresthesia. You might notice a decrease in libido. You may have a dry mouth. You might experience taste perversion. You could notice tinnitus. You may develop a rash. You might experience sweating. You may have urinary frequency. You could experience arthralgia. You might have myalgia. You may feel asthenia. You could experience pain (including chest pain and abdominal pain). You might experience syncope. Your healthcare provider may monitor you for peripheral vascular disorder. You might notice tachycardia. You could be at risk for infection. You may experience back pain. You might have flu syndrome. You could develop a fever. You may experience chills. You might have neck pain. You may notice photosensitivity. You could experience pruritus. You might develop gastroenteritis. You may experience flatulence. You might have a tooth disorder. You could experience hypesthesia. You may notice abnormal vision. You might have abnormal dreams. You could be at risk for a retinal disorder. You may develop an upper respiratory infection. You might experience epistaxis. You could develop bronchitis. You may have rhinitis. You might experience sinusitis. You could notice voice alteration. You may develop conjunctivitis. You might experience arthritis. You could be at risk for a urinary tract infection. You may notice alopecia. You could experience acute renal failure. You might develop jaundice (intrahepatic cholestatic). You may experience sialadenitis. You might have cramping. You could feel lightheaded. You may experience transient blurred vision. You might feel weakness. You could experience restlessness. You may have muscle spasms. You could be at risk for aplastic anemia. You might experience agranulocytosis. You may have leukopenia. You could experience neutropenia. You might be at risk for thrombocytopenia. You may experience hyperglycemia. You could have glycosuria. You might experience hyperuricemia. You may develop pyrexia. Your healthcare provider may monitor you for parathyroid gland changes with hypercalcemia and hypophosphatemia. You might experience anaphylactoid reactions. You could be at risk for necrotizing angiitis. You may experience respiratory distress (including pneumonitis and pulmonary edema). You might notice purpura. You could experience urticaria. You may develop erythema multiforme including Stevens-Johnson syndrome. You might experience exfoliative dermatitis including toxic epidermal necrolysis. You may experience acute transient myopia. You could be at risk for acute angle-closure glaucoma. Warnings when pregnancy is detected, discontinue benazepril hydrochloride and hydrochlorothiazide as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus patients receiving ace inhibitors may be subject to a variety of adverse reactions, some of them serious angioedema of the face, extremities, lips, tongue, glottis, and larynx has been reported in patients treated with ace inhibitors if laryngeal stridor or angioedema of the face, tongue, or glottis occurs, treatment with benazepril hydrochloride and hydrochlorothiazide should be discontinued and appropriate therapy instituted immediately when involvement of the tongue, glottis, or larynx appears likely to cause airway obstruction, appropriate therapy, e.g., subcutaneous epinephrine injection 1:1000 (0.3 to 0.5 ml) should be promptly administered black patients receiving ace inhibitors have been reported to have a higher incidence of angioedema compared to nonblacks patients receiving coadministration of ace inhibitor and mtor inhibitor may be at increased risk for angioedema intestinal angioedema has been reported in patients treated with ace inhibitors monitor renal function periodically in patients treated with benazepril hydrochloride and hydrochlorothiazide consider withholding or discontinuing therapy in patients who develop a clinically significant decrease in renal function on benazepril hydrochloride and hydrochlorothiazide monitoring of white blood cell counts should be considered in patients with collagen-vascular disease, especially if the disease is associated with impaired renal function patients receiving benazepril hydrochloride and hydrochlorothiazide should be told to report immediately any signs or symptoms suggesting angioedema female patients of childbearing age should be told about the consequences of exposure to benazepril hydrochloride and hydrochlorothiazide during pregnancy a patient receiving benazepril hydrochloride and hydrochlorothiazide should be cautioned that lightheadedness can occur, especially during the first days of therapy if syncope occurs, benazepril hydrochloride and hydrochlorothiazide should be discontinued until the physician has been consulted patients should be told not to use potassium supplements or salt substitutes containing potassium without consulting the prescribing physician patients should be told to promptly report any indication of infection (e.g., sore throat, fever), which could be a sign of neutropenia instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma untreated acute angle-closure glaucoma can lead to permanent vision loss patients receiving ace inhibitors who develop jaundice or marked elevations of hepatic enzymes should discontinue the ace inhibitor and receive appropriate medical follow-up thiazide diuretics have been reported to cause exacerbation or activation of systemic lupus erythematosus Pregnancy & Lactation a decision should be made whether to discontinue nursing or to discontinue benazepril hydrochloride and hydrochlorothiazide, taking into account the importance of the drug to the mother minimal amounts of unchanged benazepril and benazeprilat are excreted into the breast milk of lactating women treated with benazepril thiazides, on the other hand, are definitely excreted into breast milk the potential for serious adverse reactions in nursing infants from hydrochlorothiazide and the unknown effects of benazepril in infants Side Effects cough (1.0%) dizziness (1.0%) headache (0.6%) fatigue (0.6%) dizziness in 6.3% of patients fatigue in 5.2% of patients postural dizziness in 3.5% of patients headache in 3.1% of patients cough in 2.1% of patients hypertonia in 1.5% of patients vertigo in 1.5% of patients nausea in 1.4% of patients impotence in 1.2% of patients somnolence in 1.2% of patients palpitations flushing vomiting diarrhea dyspepsia anorexia constipation insomnia nervousness paresthesia libido decrease dry mouth taste perversion tinnitus rash sweating urinary frequency arthralgia myalgia asthenia pain (including chest pain and abdominal pain) syncope peripheral vascular disorder tachycardia infection back pain flu syndrome fever chills neck pain photosensitivity pruritus gastroenteritis flatulence tooth disorder hypesthesia abnormal vision abnormal dreams retinal disorder upper respiratory infection epistaxis bronchitis rhinitis sinusitis voice alteration conjunctivitis arthritis urinary tract infection alopecia acute renal failure jaundice (intrahepatic cholestatic) sialadenitis cramping lightheadedness transient blurred vision weakness restlessness muscle spasm aplastic anemia agranulocytosis leukopenia neutropenia thrombocytopenia hyperglycemia glycosuria hyperuricemia pyrexia parathyroid gland changes with hypercalcemia and hypophosphatemia anaphylactoid reactions necrotizing angiitis respiratory distress (including pneumonitis and pulmonary edema) purpura urticaria erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis acute transient myopia acute angle-closure glaucoma
Benazepril Hydrochloride and Hydrochlorothiazide Rx tablet ANI Pharmaceuticals, Inc.	Popularity – score 0 out of 100 (least-viewed drug)	21 warnings	0 pregnancy and lactation warnings	94 side effects	Trend: was flat over the year; peaks in Aug, Oct, Dec; bumpy overall.
Benazepril Hydrochloride and Hydrochlorothiazide® · First marketed 2022 · Label last revised November 26, 2025View full label details → Warnings If you find out you are pregnant, please stop taking benazepril hydrochloride and hydrochlorothiazide tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. Angioedema affecting the face, extremities, lips, tongue, glottis, and larynx has been reported in patients treated with angiotensin-converting enzyme inhibitors. If you experience laryngeal stridor or angioedema of the face, tongue, or glottis, stop taking benazepril hydrochloride and hydrochlorothiazide immediately and seek appropriate treatment. If there is a risk of airway obstruction due to involvement of the tongue, glottis, or larynx, appropriate therapy, such as a subcutaneous epinephrine injection (1:1000, 0.3 - 0.5 mL), should be administered promptly. If you are taking both an ACE inhibitor and an mTOR inhibitor, you may be at a higher risk for angioedema. Intestinal angioedema has been reported in patients treated with ACE inhibitors. Your healthcare provider should periodically monitor your renal function while you are on benazepril hydrochloride and hydrochlorothiazide. If you experience a significant decrease in renal function while taking benazepril hydrochloride and hydrochlorothiazide, your healthcare provider may consider withholding or discontinuing your therapy. Taking benazepril hydrochloride and hydrochlorothiazide can lead to symptomatic hypotension. You are more likely to experience symptomatic hypotension if you have been volume and/or salt depleted. If you have congestive heart failure, you may experience excessive hypotension. Please report any signs or symptoms of angioedema to your healthcare provider immediately. If you are a female of childbearing age, it’s important to understand the risks of taking benazepril hydrochloride and hydrochlorothiazide during pregnancy. Be aware that lightheadedness can occur, especially during the first few days of therapy. If you experience syncope, please stop taking benazepril hydrochloride and hydrochlorothiazide until you have consulted your physician. Do not use potassium supplements or salt substitutes containing potassium without first consulting your prescribing physician. Promptly report any signs of infection, as this could indicate neutropenia. If you are taking hydrochlorothiazide, protect your skin from the sun and make sure to undergo regular skin cancer screenings. If you have allergies or asthma, you may be more likely to experience hypersensitivity reactions to hydrochlorothiazide. Hydrochlorothiazide can cause an unusual reaction that may result in acute transient myopia and acute angle-closure glaucoma. Pregnancy & Lactation No pregnancy & lactation warnings reported. Side Effects You may experience a cough (1.0%). You might feel dizziness (1.0%). You could have a headache (0.6%). You may feel fatigued (0.6%). You might experience dizziness. You may feel fatigued (6.3%). You could have postural dizziness (5.2%). You might experience a headache (3.5%). You may have a cough (3.1%). You might experience hypertonia (2.1%). You could feel vertigo (1.5%). You may feel nauseous (1.5%). You might experience impotence (1.4%). You may feel somnolent (1.2%). You might experience dizziness (1.2%). You could have palpitations. You may experience flushing. You might feel nauseous and vomit. You may have diarrhea. You might experience dyspepsia. You may feel anorexic. You might have constipation. You may have trouble sleeping (insomnia). You might feel nervous. You may experience paresthesia. You might notice a decrease in libido. You may have a dry mouth. You might experience taste perversion. You may notice tinnitus. You might develop a rash. You may experience sweating. You might have urinary frequency. You may feel arthralgia. You might experience myalgia. You may feel asthenic. You might experience pain (including chest pain and abdominal pain). You may experience syncope. You might have a peripheral vascular disorder. You may feel tachycardic. You might develop an infection. You may experience back pain. You might have flu syndrome. You may develop a fever. You might experience chills. You may have neck pain. You might experience photosensitivity. You may feel pruritic. You might develop gastroenteritis. You may experience flatulence. You might have a tooth disorder. You may experience hypesthesia. You might notice abnormal vision. You may have abnormal dreams. You might develop a retinal disorder. You may experience an upper respiratory infection. You might have epistaxis. You may develop bronchitis. You might experience rhinitis. You may have sinusitis. You might notice a change in your voice. You may develop conjunctivitis. You might experience arthritis. You may develop a urinary tract infection. You might experience alopecia. You may be at risk for Stevens-Johnson syndrome. You might develop pancreatitis. You may experience hemolytic anemia. You might develop pemphigus. You may experience thrombocytopenia. You might develop eosinophilic pneumonitis. You may feel lightheaded. You might experience transient blurred vision. You may feel weak. You might feel restless. You may experience muscle spasms. You might be at risk for aplastic anemia. You may develop agranulocytosis. You might experience leukopenia. You may develop neutropenia. You might experience hyperglycemia. You may have glycosuria. You might develop hyperuricemia. You may experience pyrexia. You might feel asthenic. You may have parathyroid gland changes with hypercalcemia and hypophosphatemia. You might experience anaphylactoid reactions. You may develop necrotizing angiitis. You might experience respiratory distress (including pneumonitis and pulmonary edema). You may notice purpura. You might develop urticaria. You may experience erythema multiforme. You might develop exfoliative dermatitis. You may experience acute transient myopia. You might be at risk for acute angle-closure glaucoma. Warnings when pregnancy is detected, discontinue benazepril hydrochloride and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus angioedema of the face, extremities, lips, tongue, glottis, and larynx has been reported in patients treated with angiotensin-converting enzyme inhibitors if laryngeal stridor or angioedema of the face, tongue, or glottis occurs, treatment with benazepril hydrochloride and hydrochlorothiazide should be discontinued and appropriate therapy instituted immediately when involvement of the tongue, glottis, or larynx appears likely to cause airway obstruction, appropriate therapy, e.g., subcutaneous epinephrine injection 1:1000 (0.3 - 0.5 mL) should be promptly administered patients receiving coadministration of ACE inhibitor and mTOR inhibitor may be at increased risk for angioedema intestinal angioedema has been reported in patients treated with ACE inhibitors monitor renal function periodically in patients treated with benazepril hydrochloride and hydrochlorothiazide consider withholding or discontinuing therapy in patients who develop a clinically significant decrease in renal function on benazepril hydrochloride and hydrochlorothiazide patients receiving benazepril hydrochloride and hydrochlorothiazide can cause symptomatic hypotension symptomatic hypotension is most likely to occur in patients who have been volume and/or salt depleted patients with congestive heart failure may experience excessive hypotension patients should be told to report immediately any signs or symptoms suggesting angioedema female patients of childbearing age should be told about the consequences of exposure to benazepril hydrochloride and hydrochlorothiazide during pregnancy patients should be cautioned that lightheadedness can occur, especially during the first days of therapy if syncope occurs, benazepril hydrochloride and hydrochlorothiazide should be discontinued until the physician has been consulted patients should be told not to use potassium supplements or salt substitutes containing potassium without consulting the prescribing physician patients should be told to promptly report any indication of infection, which could be a sign of neutropenia instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening patients with allergy and asthma are more likely to experience hypersensitivity reactions to hydrochlorothiazide hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma Pregnancy & Lactation No pregnancy & lactation warnings reported. Side Effects cough (1.0%) dizziness (1.0%) headache (0.6%) fatigue (0.6%) dizziness fatigue (6.3%) postural dizziness (5.2%) headache (3.5%) cough (3.1%) hypertonia (2.1%) vertigo (1.5%) nausea (1.5%) impotence (1.4%) somnolence (1.2%) dizziness (1.2%) palpitations flushing vomiting diarrhea dyspepsia anorexia constipation insomnia nervousness paresthesia libido decrease dry mouth taste perversion tinnitus rash sweating urinary frequency arthralgia myalgia asthenia pain (including chest pain and abdominal pain) syncope peripheral vascular disorder tachycardia infection back pain flu syndrome fever chills neck pain photosensitivity pruritus gastroenteritis flatulence tooth disorder hypesthesia abnormal vision abnormal dreams retinal disorder upper respiratory infection epistaxis bronchitis rhinitis sinusitis voice alteration conjunctivitis arthritis urinary tract infection alopecia Stevens-Johnson syndrome pancreatitis hemolytic anemia pemphigus thrombocytopenia eosinophilic pneumonitis lightheadedness transient blurred vision weakness restlessness muscle spasm aplastic anemia agranulocytosis leukopenia neutropenia hyperglycemia glycosuria hyperuricemia pyrexia asthenia parathyroid gland changes with hypercalcemia and hypophosphatemia anaphylactoid reactions necrotizing angiitis respiratory distress (including pneumonitis and pulmonary edema) purpura urticaria erythema multiforme exfoliative dermatitis acute transient myopia acute angle-closure glaucoma
Benazepril Hydrochloride and Hydrochlorothiazide Rx tablet Apotex Corp.	Popularity – score 0 out of 100 (least-viewed drug)	23 warnings	3 pregnancy and lactation warnings	86 side effects	Trend: was flat over the year; peaks in Aug, Oct, Dec; bumpy overall.
Benazepril Hydrochloride and Hydrochlorothiazide® · First marketed 2014 · Label last revised June 16, 2025View full label details → Warnings If you find out you are pregnant, please stop taking benazepril hydrochloride and hydrochlorothiazide tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. Angioedema affecting the face, extremities, lips, tongue, glottis, and larynx has been reported in patients treated with angiotensin-converting enzyme inhibitors. If you experience laryngeal stridor or angioedema of the face, tongue, or glottis, stop taking benazepril hydrochloride and hydrochlorothiazide tablets immediately and seek appropriate treatment. Black patients taking ACE inhibitors may have a higher risk of experiencing angioedema compared to nonblack patients. If you are taking both an ACE inhibitor and an mTOR inhibitor, you may be at an increased risk for angioedema. Intestinal angioedema has been reported in patients treated with ACE inhibitors. Your healthcare provider should periodically monitor your renal function while you are taking benazepril hydrochloride and hydrochlorothiazide tablets. If you experience a significant decrease in renal function while on benazepril hydrochloride and hydrochlorothiazide tablets, your healthcare provider may consider withholding or stopping your therapy. If you have collagen-vascular disease, especially with impaired renal function, your healthcare provider should monitor your white blood cell counts. Benazepril hydrochloride and hydrochlorothiazide tablets can cause symptomatic hypotension. You are more likely to experience symptomatic hypotension if you have been depleted of volume and/or salt. If you have congestive heart failure, ACE inhibitor therapy may lead to excessive hypotension. If you develop jaundice or significant elevations in hepatic enzymes while taking ACE inhibitors, you should stop the medication and seek appropriate medical follow-up. Thiazide diuretics may worsen or activate systemic lupus erythematosus. Hydrochlorothiazide can cause an unusual reaction, leading to acute transient myopia and acute angle-closure glaucoma. If you are taking benazepril hydrochloride and hydrochlorothiazide tablets, please report any signs or symptoms of angioedema immediately. If you are a female of childbearing age, it’s important to understand the risks of taking benazepril hydrochloride and hydrochlorothiazide tablets during pregnancy. You should be aware that lightheadedness can occur while taking benazepril hydrochloride and hydrochlorothiazide tablets. If you experience fainting, please stop taking benazepril hydrochloride and hydrochlorothiazide tablets until you have consulted your physician. Do not use potassium supplements or salt substitutes containing potassium without first consulting your prescribing physician while taking benazepril hydrochloride and hydrochlorothiazide tablets. Please report any signs of infection promptly, as this could indicate neutropenia. If you are taking hydrochlorothiazide, remember to protect your skin from the sun and schedule regular skin cancer screenings. Pregnancy & Lactation You should decide whether to continue nursing or to stop taking benazepril hydrochloride and hydrochlorothiazide tablets, considering how important the medication is for you. Only minimal amounts of unchanged benazepril and benazeprilat are found in the breast milk of women who are nursing and taking benazepril, meaning that a newborn who is exclusively breastfed would receive less than 0.1% of the doses you take. However, thiazides are definitely present in breast milk. Side Effects You may experience dizziness. Fatigue can occur. You might notice postural dizziness. Headaches are possible. Coughing may happen. Hypertonia could be a side effect. You may feel vertigo. Nausea is a potential effect. Impotence might occur. Somnolence can happen. You may experience palpitations. Flushing may be noticeable. Vomiting is a possible side effect. Diarrhea can occur. Dyspepsia might be experienced. You may have a decrease in appetite (anorexia). Constipation is a potential effect. Insomnia may occur. Nervousness can happen. You might feel paresthesia. A decrease in libido may occur. Dry mouth is a possible side effect. You may experience taste perversion. Tinnitus could be noticeable. A rash may develop. Increased sweating is possible. You might notice urinary frequency. Arthralgia can occur. Myalgia may be experienced. You might feel asthenia. Pain, including chest pain and abdominal pain, can occur. Syncope is a potential side effect. Peripheral vascular disorder may happen. Tachycardia could be experienced. Infection is a possible effect. You may feel back pain. Flu syndrome can occur. Fever might be experienced. Chills may happen. You might notice neck pain. Photosensitivity is a potential side effect. Pruritus could occur. Gastroenteritis may happen. Flatulence is possible. You might experience a tooth disorder. Hypesthesia can occur. Abnormal vision may be experienced. You might have abnormal dreams. A retinal disorder is a potential effect. Upper respiratory infection may occur. Epistaxis could happen. Bronchitis is a possible side effect. Rhinitis may occur. Sinusitis could be experienced. Voice alteration might happen. Conjunctivitis is a potential effect. Arthritis may occur. You might experience a urinary tract infection. Alopecia can happen. Acute renal failure is a serious potential effect. Jaundice (intrahepatic cholestatic) may occur. Sialadenitis could happen. Cramping is a possible side effect. Gastric irritation may occur. Acute myopia might be experienced. Acute angle-closure glaucoma is a serious potential effect. Anaphylactoid reactions may occur. Stevens-Johnson syndrome is a serious potential effect. Pancreatitis could happen. Hemolytic anemia is a serious potential effect. Pemphigus may occur. Thrombocytopenia is a serious potential effect. Eosinophilic pneumonitis could happen. Muscle spasms may occur. Aplastic anemia is a serious potential effect. Agranulocytosis is a serious potential effect. Leukopenia may occur. Neutropenia is a serious potential effect. Hyperglycemia could happen. Glycosuria may occur. Hyperuricemia is a potential effect. Pyrexia might be experienced. Changes in the parathyroid gland with hypercalcemia and hypophosphatemia may occur. Anaphylactoid reactions during desensitization could happen. Anaphylactoid reactions during membrane exposure may occur. Exacerbation or activation of systemic lupus erythematosus is a serious potential effect. Warnings when pregnancy is detected, discontinue benazepril hydrochloride and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus angioedema of the face, extremities, lips, tongue, glottis, and larynx has been reported in patients treated with angiotensin-converting enzyme inhibitors if laryngeal stridor or angioedema of the face, tongue, or glottis occurs, treatment with benazepril hydrochloride and hydrochlorothiazide tablets should be discontinued and appropriate therapy instituted immediately black patients receiving ACE inhibitors have been reported to have a higher incidence of angioedema compared to nonblacks patients receiving coadministration of ACE inhibitor and mTOR inhibitor may be at increased risk for angioedema intestinal angioedema has been reported in patients treated with ACE inhibitors monitor renal function periodically in patients treated with benazepril hydrochloride and hydrochlorothiazide tablets consider withholding or discontinuing therapy in patients who develop a clinically significant decrease in renal function on benazepril hydrochloride and hydrochlorothiazide tablets monitor white blood cell counts in patients with collagen-vascular disease, especially if the disease is associated with impaired renal function benazepril hydrochloride and hydrochlorothiazide tablets can cause symptomatic hypotension symptomatic hypotension is most likely to occur in patients who have been volume and/or salt depleted in patients with congestive heart failure, ACE inhibitor therapy may cause excessive hypotension patients receiving ACE inhibitors who develop jaundice or marked elevations of hepatic enzymes should discontinue the ACE inhibitor and receive appropriate medical follow-up thiazide diuretics have been reported to cause exacerbation or activation of systemic lupus erythematosus hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma a patient receiving benazepril hydrochloride and hydrochlorothiazide tablets should be told to report immediately any signs or symptoms suggesting angioedema female patients of childbearing age should be told about the consequences of exposure to benazepril hydrochloride and hydrochlorothiazide tablets during pregnancy a patient receiving benazepril hydrochloride and hydrochlorothiazide tablets should be cautioned that lightheadedness can occur if syncope occurs, benazepril hydrochloride and hydrochlorothiazide tablets should be discontinued until the physician has been consulted a patient receiving benazepril hydrochloride and hydrochlorothiazide tablets should be told not to use potassium supplements or salt substitutes containing potassium without consulting the prescribing physician patients should be told to promptly report any indication of infection, which could be a sign of neutropenia instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening Pregnancy & Lactation a decision should be made whether to discontinue nursing or to discontinue benazepril hydrochloride and hydrochlorothiazide tablets, taking into account the importance of the drug to the mother minimal amounts of unchanged benazepril and benazeprilat are excreted into the breast milk of lactating women treated with benazepril, so that a newborn child ingesting nothing but breast milk would receive less than 0.1% of the maternal doses of benazepril and benazeprilat thiazides, on the other hand, are definitely excreted into breast milk Side Effects dizziness fatigue postural dizziness headache cough hypertonia vertigo nausea impotence somnolence palpitations flushing vomiting diarrhea dyspepsia anorexia constipation insomnia nervousness paresthesia libido decrease dry mouth taste perversion tinnitus rash sweating urinary frequency arthralgia myalgia asthenia pain (including chest pain and abdominal pain) syncope peripheral vascular disorder tachycardia infection back pain flu syndrome fever chills neck pain photosensitivity pruritus gastroenteritis flatulence tooth disorder hypesthesia abnormal vision abnormal dreams retinal disorder upper respiratory infection epistaxis bronchitis rhinitis sinusitis voice alteration conjunctivitis arthritis urinary tract infection alopecia acute renal failure jaundice (intrahepatic cholestatic) sialadenitis cramping gastric irritation acute myopia acute angle-closure glaucoma anaphylactoid reactions Stevens-Johnson syndrome pancreatitis hemolytic anemia pemphigus thrombocytopenia eosinophilic pneumonitis muscle spasm aplastic anemia agranulocytosis leukopenia neutropenia hyperglycemia glycosuria hyperuricemia pyrexia parathyroid gland changes with hypercalcemia and hypophosphatemia anaphylactoid reactions during desensitization anaphylactoid reactions during membrane exposure exacerbation or activation of systemic lupus erythematosus
Benicar Hct (olmesartan medoxomil-hydrochlorothiazide) Rx tablet, film coated Cosette Pharmaceuticals, Inc.	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	7 pregnancy and lactation warnings	8 side effects	Trend: fell 32% over 11 months; peaks in Mar, Aug, Sep.
Benicar Hct® · First marketed 2022 · Label last revised July 12, 2023View full label details → Warnings If you find out you are pregnant, please stop taking Benicar HCT as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. Make sure to correct any volume depletion before starting treatment. Your healthcare provider should regularly check your renal function and potassium levels if you are at risk. Be alert for any signs of fluid or electrolyte imbalance. Be aware of the risk of acute angle-closure glaucoma. There have been reports of sprue-like enteropathy. If no other cause is identified, consider discussing the discontinuation of Benicar HCT with your healthcare provider. Pregnancy & Lactation Using drugs that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal renal function and increase the risk of morbidity and death for both the fetus and neonate. If you find out you are pregnant, please discontinue BENICAR HCT as soon as possible. In the rare case that there is no suitable alternative to therapy with drugs affecting the renin-angiotensin system for your situation, make sure to discuss the potential risks to your fetus with your healthcare provider. Your healthcare provider may perform serial ultrasound examinations to assess the intraamniotic environment. If oligohydramnios is detected, you should discontinue BENICAR HCT, unless your healthcare provider considers it lifesaving for you. Infants with a history of in utero exposure to BENICAR HCT should be closely monitored for hypotension, oliguria, and hyperkalemia. You and your healthcare provider should decide whether to continue nursing or to discontinue BENICAR HCT, considering the importance of the medication for you. Side Effects You may experience nausea. You might have hyperuricemia. Dizziness can occur. An upper respiratory infection may develop. You could experience hypotension. There may be a fluid or electrolyte imbalance. Your healthcare provider should monitor you for acute angle-closure glaucoma. Sprue-like enteropathy is a possible side effect. Warnings when pregnancy is detected, discontinue benicar hct as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume-depletion prior to administration monitor renal function and potassium in susceptible patients observe for signs of fluid or electrolyte imbalance acute angle-closure glaucoma sprue-like enteropathy has been reported. consider discontinuation of benicar hct in cases where no other etiology is found Pregnancy & Lactation use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity, and death when pregnancy is detected, discontinue BENICAR HCT as soon as possible in the unusual case that there is no appropriate alternative to therapy with drugs affecting the renin-angiotensin system for a particular patient, apprise the mother of the potential risk to the fetus perform serial ultrasound examinations to assess the intraamniotic environment if oligohydramnios is observed, discontinue BENICAR HCT, unless it is considered lifesaving for the mother closely observe infants with histories of in utero exposure to BENICAR HCT for hypotension, oliguria, and hyperkalemia a decision should be made whether to discontinue nursing or discontinue BENICAR HCT, taking into account the importance of the drug to the mother Side Effects nausea hyperuricemia dizziness upper respiratory infection hypotension fluid or electrolyte imbalance acute angle-closure glaucoma sprue-like enteropathy
Bisoprolol Fumarate and Hydrochlorothiazide Rx tablet, film coated Teva Pharmaceuticals USA, Inc.	Popularity – score 0 out of 100 (least-viewed drug)	25 warnings	1 pregnancy and lactation warnings	68 side effects	Trend: rose 40% over the year; peak in Sep.
Bisoprolol Fumarate and Hydrochlorothiazide® · First marketed 2019 · Label last revised August 14, 2025View full label details → Warnings You should avoid beta-blocking agents if you have overt congestive failure. If you have compensated cardiac failure, use beta-blockers cautiously. Continued use of beta-blockers can lead to worsening cardiac failure. At the first signs or symptoms of heart failure, consider discontinuing bisoprolol fumarate and hydrochlorothiazide tablets. Please do not interrupt or stop your therapy without consulting your physician. It may be advisable to taper your therapy with bisoprolol fumarate and hydrochlorothiazide tablets over about a week while being carefully observed. Beta-blockers can worsen symptoms of arterial insufficiency if you have peripheral vascular disease. If you have bronchospastic pulmonary disease, you generally should not receive beta-blockers. Use the lowest possible dose of bisoprolol fumarate and hydrochlorothiazide tablets if you have bronchospastic disease. Make sure a beta agonist (bronchodilator) is available if you have bronchospastic disease. If you are on chronically administered beta-blocking therapy, it should not be routinely withdrawn before major surgery. Beta-blockers may prevent early warning signs of hypoglycemia, like tachycardia. If you have diabetes mellitus, are a child, or are fasting, you are at increased risk for severe or prolonged hypoglycemia. If you experience severe hypoglycemia, seek emergency treatment immediately. Beta-adrenergic blockade may mask clinical signs of hyperthyroidism, such as tachycardia. Abruptly stopping beta-blockade may worsen symptoms of hyperthyroidism or trigger a thyroid storm. Thiazides may cause azotemia if you have impaired renal function. If you notice progressive renal impairment, bisoprolol fumarate and hydrochlorothiazide tablets should be discontinued. Use bisoprolol fumarate and hydrochlorothiazide tablets with caution if you have impaired hepatic function or progressive liver disease. Thiazides may disrupt fluid and electrolyte balance, potentially leading to hepatic coma. Hydrochlorothiazide can cause an idiosyncratic reaction that results in acute angle-closure glaucoma. If left untreated, acute angle-closure glaucoma may lead to permanent visual field loss. Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. If you have a history of severe anaphylactic reactions to various allergens, you may be more reactive to repeated challenges while taking beta-blockers. You may not respond to the usual doses of epinephrine used to treat allergic reactions. Pregnancy & Lactation You should decide whether to stop nursing or to discontinue the medication, considering how important the medication is for you. Side Effects You may experience bradycardia. You might notice arrhythmia. Peripheral ischemia could occur. Chest pain may be a possibility. Bronchospasm might happen. You could have a cough. Rhinitis may develop. You might experience an upper respiratory infection (URI). Asthenia could be a concern. Fatigue may affect you. Peripheral edema might occur. Dizziness could be experienced. You may have headaches. Muscle cramps might happen. You could experience myalgia. Insomnia may affect you. Somnolence might occur. You may notice a loss of libido. Impotence could be a possibility. Diarrhea may occur. Nausea might affect you. Dyspepsia could be experienced. You may feel weakness. Vertigo might occur. Paresthesia could be a concern. You might feel restlessness. Your healthcare provider may monitor you for orthostatic hypotension. Anorexia may develop. Gastric irritation could occur. Cramping might happen. You may experience constipation. Jaundice (intrahepatic cholestatic jaundice) could occur. Pancreatitis may be a concern. Cholecystitis might happen. Sialadenitis could occur. You may experience dry mouth. Muscle spasms might happen. Purpura could be a possibility. Photosensitivity may affect you. You might develop a rash. Urticaria could occur. Necrotizing angiitis (vasculitis and cutaneous vasculitis) may be a concern. Fever might occur. You may experience respiratory distress, including pneumonitis and pulmonary edema. Anaphylactic reactions could happen. Transient blurred vision might occur. Choroidal effusion may be a possibility. You might notice xanthopsia. Gout could be a concern. Sexual dysfunction may affect you. Renal failure might occur. You may experience renal dysfunction. Interstitial nephritis could be a possibility. Erythema multiforme, including Stevens-Johnson syndrome, may occur. Exfoliative dermatitis, including toxic epidermal necrolysis, might happen. Hyperglycemia could be a concern. Glycosuria may occur. Hyperuricemia might affect you. You may experience hypokalemia and other electrolyte imbalances. Hyperlipidemia could occur. Hypercalcemia may be a possibility. Leukopenia might happen. Agranulocytosis could be a concern. Thrombocytopenia may occur. Aplastic anemia might happen. Hemolytic anemia could be a possibility. Mesenteric arterial thrombosis may occur. Ischemic colitis might be a concern. Warnings beta-blocking agents should be avoided in patients with overt congestive failure in some patients with compensated cardiac failure, beta-blockers must be used cautiously continued depression of the myocardium with beta-blockers can precipitate cardiac failure at the first signs or symptoms of heart failure, discontinuation of bisoprolol fumarate and hydrochlorothiazide tablets should be considered patients should be cautioned against interruption or discontinuation of therapy without the physician’s advice it may be advisable to taper therapy with bisoprolol fumarate and hydrochlorothiazide tablets over approximately 1 week with the patient under careful observation beta-blockers can precipitate or aggravate symptoms of arterial insufficiency in patients with peripheral vascular disease patients with bronchospastic pulmonary disease should, in general, not receive beta-blockers the lowest possible dose of bisoprolol fumarate and hydrochlorothiazide tablets should be used in patients with bronchospastic disease a beta agonist (bronchodilator) should be made available for patients with bronchospastic disease chronically administered beta-blocking therapy should not be routinely withdrawn prior to major surgery beta-blockers may prevent early warning signs of hypoglycemia, such as tachycardia patients with diabetes mellitus or children and patients who are fasting are at increased risk for severe or prolonged hypoglycemia if severe hypoglycemia occurs, patients should be instructed to seek emergency treatment beta-adrenergic blockade may mask clinical signs of hyperthyroidism, such as tachycardia abrupt withdrawal of beta-blockade may be followed by an exacerbation of the symptoms of hyperthyroidism or may precipitate thyroid storm thiazides may precipitate azotemia in patients with impaired renal function if progressive renal impairment becomes apparent, bisoprolol fumarate and hydrochlorothiazide tablets should be discontinued bisoprolol fumarate and hydrochlorothiazide tablets should be used with caution in patients with impaired hepatic function or progressive liver disease thiazides may alter fluid and electrolyte balance, which may precipitate hepatic coma hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute angle-closure glaucoma untreated, the acute angle-closure glaucoma may result in permanent visual field loss risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy patients with a history of severe anaphylactic reaction to a variety of allergens may be more reactive to repeated challenge while taking beta-blockers patients may be unresponsive to the usual doses of epinephrine used to treat allergic reactions Pregnancy & Lactation a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother Side Effects bradycardia arrhythmia peripheral ischemia chest pain bronchospasm cough rhinitis URI asthenia fatigue peripheral edema dizziness headache muscle cramps myalgia insomnia somnolence loss of libido impotence diarrhea nausea dyspepsia weakness vertigo paresthesia restlessness orthostatic hypotension anorexia gastric irritation cramping constipation jaundice (intrahepatic cholestatic jaundice) pancreatitis cholecystitis sialadenitis dry mouth muscle spasm purpura photosensitivity rash urticaria necrotizing angiitis (vasculitis and cutaneous vasculitis) fever respiratory distress including pneumonitis and pulmonary edema anaphylactic reactions transient blurred vision choroidal effusion xanthopsia gout sexual dysfunction renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis hyperglycemia glycosuria hyperuricemia hypokalemia and other electrolyte imbalances hyperlipidemia hypercalcemia leukopenia agranulocytosis thrombocytopenia aplastic anemia hemolytic anemia mesenteric arterial thrombosis ischemic colitis
Bisoprolol Fumarate and Hydrochlorothiazide Rx tablet, film coated Edenbridge Pharmaceuticals LLC.	Popularity – score 0 out of 100 (least-viewed drug)	23 warnings	3 pregnancy and lactation warnings	134 side effects	Trend: rose 40% over the year; peak in Sep.
Bisoprolol Fumarate and Hydrochlorothiazide® · First marketed 2019 · Label last revised December 18, 2025View full label details → Warnings You should avoid beta-blocking agents if you have overt congestive failure. Consider stopping bisoprolol fumarate and hydrochlorothiazide tablets at the first signs or symptoms of heart failure. If you have coronary artery disease, be cautious about interrupting or stopping therapy without your physician’s advice. It may be advisable for you to taper therapy with bisoprolol fumarate and hydrochlorothiazide tablets over approximately 1 week while under careful observation. Beta-blockers can worsen symptoms of arterial insufficiency if you have peripheral vascular disease. In general, you should not receive beta-blockers if you have bronchospastic pulmonary disease. If you have bronchospastic disease, the lowest possible dose of bisoprolol fumarate and hydrochlorothiazide tablets should be used. Make sure a beta agonist (bronchodilator) is available if you have bronchospastic disease. If you are on chronically administered beta-blocking therapy, it should not be routinely withdrawn before major surgery. Beta-blockers may prevent early warning signs of hypoglycemia, such as tachycardia. If you have diabetes mellitus, or if you are a child or fasting, you should be monitored for symptoms of hypoglycemia. If you experience severe hypoglycemia, seek emergency treatment immediately. Beta-adrenergic blockade may mask clinical signs of hyperthyroidism. If you notice progressive renal impairment, bisoprolol fumarate and hydrochlorothiazide tablets should be discontinued. Use bisoprolol fumarate and hydrochlorothiazide tablets with caution if you have impaired hepatic function or progressive liver disease. Hydrochlorothiazide can cause an idiosyncratic reaction, leading to acute angle-closure glaucoma. You should protect your skin from the sun and undergo regular skin cancer screening while taking hydrochlorothiazide. If you experience visual field defects, decreased visual acuity, or ocular pain while taking hydrochlorothiazide, consult your healthcare provider immediately. If you have a history of severe anaphylactic reactions to various allergens, you may be more reactive to repeated challenges while taking beta-blockers. If you are receiving thiazides, your healthcare provider should observe you closely to ensure the desired effect of the diuretic is achieved when used with nonsteroidal anti-inflammatory agents. Sensitivity reactions may occur with or without a history of allergy or bronchial asthma if you are receiving thiazides. If you are pregnant, the use of thiazides requires weighing the anticipated benefit against possible hazards to the fetus. You should decide whether to discontinue nursing or to stop the drug, considering the importance of the drug to you. Pregnancy & Lactation You should decide whether to stop nursing or to discontinue the drug, considering how important the medication is for you. You should use bisoprolol fumarate and hydrochlorothiazide tablets during pregnancy only if the potential benefits outweigh the risks to your baby. This drug should only be used during pregnancy if it is clearly necessary. Side Effects You may experience unsteadiness. Dizziness can occur. You might feel vertigo. Headaches are possible. Syncope may happen. You could notice paresthesia. Hypoesthesia might be experienced. You may have hyperesthesia. Sleep disturbances or vivid dreams can occur. Insomnia is a potential side effect. Somnolence may affect you. Depression could be a concern. You might feel anxiety or restlessness. Decreased concentration or memory issues may arise. Bradycardia is a possibility. Palpitations and other rhythm disturbances may occur. You might experience cold extremities. Claudication can happen. Hypotension may be a side effect. Orthostatic hypotension could occur. You may experience chest pain. Congestive heart failure is a serious concern. Dyspnea on exertion might affect you. Gastric, epigastric, or abdominal pain can occur. Peptic ulcers may develop. Gastritis is a possibility. Dyspepsia might be experienced. Nausea can occur. You may experience vomiting. Diarrhea is a potential side effect. Constipation might affect you. Dry mouth can occur. You may experience arthralgia. Muscle or joint pain is possible. Back or neck pain might occur. Muscle cramps can happen. You might notice twitching or tremors. A rash may develop. Acne is a possibility. Eczema might occur. Psoriasis can happen. Skin irritation may affect you. Pruritus is a potential side effect. Purpura might be experienced. Flushing can occur. You may experience sweating. Alopecia is a possibility. Dermatitis might develop. Exfoliative dermatitis (very rarely) can occur. Cutaneous vasculitis may happen. You might experience visual disturbances. Ocular pain or pressure can occur. Abnormal lacrimation may affect you. Tinnitus is a possibility. Decreased hearing might occur. You may experience earache. Taste abnormalities can happen. Gout is a potential concern. Asthma may be triggered. Bronchospasm can occur. Bronchitis might affect you. Dyspnea is a possibility. Pharyngitis may occur. Rhinitis can happen. Sinusitis might affect you. You may experience an upper respiratory infection (URI). Decreased libido or impotence is a possibility. Peyronie’s disease (very rarely) may occur. Cystitis can happen. You might experience renal colic. Polyuria is a potential side effect. Fatigue may affect you. Asthenia might occur. You may feel malaise. Edema can happen. Weight gain is a possibility. Angioedema may occur. Reversible mental depression progressing to catatonia is a serious concern. Hallucinations might happen. An acute reversible syndrome characterized by disorientation to time and place may occur. Emotional lability can affect you. You might experience a slightly clouded sensorium. Fever is a potential side effect. You may experience fever combined with aching and a sore throat. Laryngospasm can occur. Respiratory distress is a serious concern. Agranulocytosis is a rare but serious side effect. Thrombocytopenia may occur. Mesenteric arterial thrombosis is a serious concern. Ischemic colitis might happen. You may feel weakness. Vertigo can occur. Paresthesia might affect you. Restlessness is a possibility. Orthostatic hypotension (may be potentiated by alcohol, barbiturates, or narcotics) can occur. Anorexia may happen. Gastric irritation is a potential side effect. Cramping might occur. Constipation can happen. Jaundice (intrahepatic cholestatic jaundice) is a serious concern. Pancreatitis may occur. Cholecystitis is a possibility. Sialadenitis might happen. You may experience dry mouth. Muscle spasms can occur. Purpura might be experienced. Photosensitivity is a potential side effect. A rash may develop. Urticaria can happen. Necrotizing angiitis (vasculitis and cutaneous vasculitis) is a serious concern. Fever may occur. Respiratory distress including pneumonitis and pulmonary edema is a serious concern. Anaphylactic reactions are a serious risk. You might experience transient blurred vision. Choroidal effusion can occur. Xanthopsia is a possibility. Gout may affect you. Sexual dysfunction is a potential concern. Renal failure is a serious risk. Renal dysfunction may occur. Interstitial nephritis is a serious concern. Erythema multiforme including Stevens-Johnson syndrome is a serious risk. Exfoliative dermatitis including toxic epidermal necrolysis is a serious concern. Hyperglycemia may occur. Glycosuria is a possibility. Hyperuricemia might affect you. Hypokalemia and other electrolyte imbalances can occur. Hyperlipidemia is a potential concern. Hypercalcemia may happen. Leukopenia is a possibility. Agranulocytosis is a serious risk. Thrombocytopenia may occur. Aplastic anemia is a serious concern. Hemolytic anemia might affect you. Warnings beta-blocking agents should be avoided in patients with overt congestive failure discontinuation of bisoprolol fumarate and hydrochlorothiazide tablets should be considered at the first signs or symptoms of heart failure patients with coronary artery disease should be cautioned against interruption or discontinuation of therapy without the physician’s advice it may be advisable to taper therapy with bisoprolol fumarate and hydrochlorothiazide tablets over approximately 1 week with the patient under careful observation beta-blockers can precipitate or aggravate symptoms of arterial insufficiency in patients with peripheral vascular disease patients with bronchospastic pulmonary disease should, in general, not receive beta-blockers the lowest possible dose of bisoprolol fumarate and hydrochlorothiazide tablets should be used in patients with bronchospastic disease a beta agonist (bronchodilator) should be made available for patients with bronchospastic disease chronically administered beta-blocking therapy should not be routinely withdrawn prior to major surgery beta-blockers may prevent early warning signs of hypoglycemia, such as tachycardia patients with diabetes mellitus or children and patients who are fasting should be monitored for symptoms of hypoglycemia if severe hypoglycemia occurs, patients should be instructed to seek emergency treatment beta-adrenergic blockade may mask clinical signs of hyperthyroidism if progressive renal impairment becomes apparent, bisoprolol fumarate and hydrochlorothiazide tablets should be discontinued bisoprolol fumarate and hydrochlorothiazide tablets should be used with caution in patients with impaired hepatic function or progressive liver disease hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute angle-closure glaucoma patients should be instructed to protect skin from the sun and undergo regular skin cancer screening while taking hydrochlorothiazide patients taking hydrochlorothiazide should immediately consult their healthcare provider if visual field defects, decreased visual acuity, or ocular pain occur patients with a history of severe anaphylactic reaction to a variety of allergens may be more reactive to repeated challenge while taking beta-blockers patients receiving thiazides should be observed closely to determine if the desired effect of the diuretic is obtained when used with nonsteroidal anti-inflammatory agents sensitivity reactions may occur with or without a history of allergy or bronchial asthma in patients receiving thiazides the use of thiazides in pregnant women requires that the anticipated benefit be weighed against possible hazards to the fetus a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother Pregnancy & Lactation a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother bisoprolol fumarate and hydrochlorothiazide tablets should be used during pregnancy only if the potential benefit justifies the risk to the fetus this drug should be used during pregnancy only if clearly needed Side Effects unsteadiness dizziness vertigo headache syncope paresthesia hypoesthesia hyperesthesia sleep disturbance/vivid dreams insomnia somnolence depression anxiety/restlessness decreased concentration/memory bradycardia palpitations and other rhythm disturbances cold extremities claudication hypotension orthostatic hypotension chest pain congestive heart failure dyspnea on exertion gastric/epigastric/abdominal pain peptic ulcer gastritis dyspepsia nausea vomiting diarrhea constipation dry mouth arthralgia muscle/joint pain back/neck pain muscle cramps twitching/tremor rash acne eczema psoriasis skin irritation pruritus purpura flushing sweating alopecia dermatitis exfoliative dermatitis (very rarely) cutaneous vasculitis visual disturbances ocular pain/pressure abnormal lacrimation tinnitus decreased hearing earache taste abnormalities gout asthma bronchospasm bronchitis dyspnea pharyngitis rhinitis sinusitis URI (upper respiratory infection) decreased libido/impotence Peyronie’s disease (very rarely) cystitis renal colic polyuria fatigue asthenia malaise edema weight gain angioedema reversible mental depression progressing to catatonia hallucinations acute reversible syndrome characterized by disorientation to time and place emotional lability slightly clouded sensorium fever combined with aching and sore throat laryngospasm respiratory distress agranulocytosis thrombocytopenia mesenteric arterial thrombosis ischemic colitis weakness vertigo paresthesia restlessness orthostatic hypotension (may be potentiated by alcohol, barbiturates, or narcotics) anorexia gastric irritation cramping constipation jaundice (intrahepatic cholestatic jaundice) pancreatitis cholecystitis sialadenitis dry mouth muscle spasm purpura photosensitivity rash urticaria necrotizing angiitis (vasculitis and cutaneous vasculitis) fever respiratory distress including pneumonitis and pulmonary edema anaphylactic reactions transient blurred vision choroidal effusion xanthopsia gout sexual dysfunction renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis hyperglycemia glycosuria hyperuricemia hypokalemia and other electrolyte imbalances hyperlipidemia hypercalcemia leukopenia agranulocytosis thrombocytopenia aplastic anemia hemolytic anemia
Bisoprolol Fumarate and Hydrochlorothiazide Rx tablet, film coated Zydus Lifesciences Limited	Popularity – score 0 out of 100 (least-viewed drug)	0 warnings	0 pregnancy and lactation warnings	0 side effects	Trend: rose 40% over the year; peak in Sep.
Bisoprolol Fumarate and Hydrochlorothiazide® · First marketed 2023 · Label last revised November 7, 2022View full label details → Warnings No warnings reported. Pregnancy & Lactation No pregnancy & lactation warnings reported. Side Effects No side effects reported. Warnings No warnings reported. Pregnancy & Lactation No pregnancy & lactation warnings reported. Side Effects No side effects reported.
Bisoprolol Fumarate and Hydrochlorothiazide Rx tablet, film coated Viona Pharmaceuticals Inc	Popularity – score 0 out of 100 (least-viewed drug)	23 warnings	3 pregnancy and lactation warnings	67 side effects	Trend: rose 40% over the year; peak in Sep.
Bisoprolol Fumarate and Hydrochlorothiazide® · First marketed 2023 · Label last revised January 11, 2024View full label details → Warnings You should avoid beta-blocking agents if you have overt congestive failure. Continued depression of your heart muscle with beta-blockers can lead to cardiac failure. At the first signs or symptoms of heart failure, you should consider discontinuing bisoprolol fumarate and hydrochlorothiazide. If you have coronary artery disease, be aware that stopping beta-blockers suddenly can lead to worsening angina, myocardial infarction, or ventricular arrhythmia. Please do not interrupt or stop your therapy without consulting your physician. If you have peripheral vascular disease, exercise caution as beta-blockers can worsen symptoms of arterial insufficiency. In general, you should not receive beta-blockers if you have bronchospastic pulmonary disease. If you have bronchospastic disease, the lowest possible dose of bisoprolol fumarate and hydrochlorothiazide should be used. Make sure a beta agonist (bronchodilator) is available if you have bronchospastic disease. If you are on chronic beta-blocking therapy, it should not be routinely stopped before major surgery. Be aware that beta-blockers may mask early warning signs of hypoglycemia, such as a rapid heartbeat. If you have diabetes mellitus, or if you are a child or fasting, you are at increased risk for severe or prolonged hypoglycemia. If you experience severe hypoglycemia, you should seek emergency treatment immediately. Beta-adrenergic blockade may hide clinical signs of hyperthyroidism. Abruptly stopping beta-blockade may worsen your hyperthyroidism symptoms or trigger a thyroid storm. If you have impaired renal function, be aware that cumulative effects of thiazides may develop. If you notice progressive renal impairment, bisoprolol fumarate and hydrochlorothiazide should be discontinued. Use bisoprolol fumarate and hydrochlorothiazide with caution if you have impaired hepatic function or progressive liver disease. Hydrochlorothiazide can cause an idiosyncratic reaction, leading to acute angle-closure glaucoma and elevated intraocular pressure. If you have a history of sulfonamide or penicillin allergy, you may be at risk for developing acute angle-closure glaucoma. If you have a history of severe anaphylactic reactions to various allergens, you may be more reactive to repeated exposure while taking beta-blockers. You may not respond to the usual doses of epinephrine used to treat allergic reactions. If you are taking thiazides, you may experience sensitivity reactions, even if you do not have a history of allergy or bronchial asthma. Pregnancy & Lactation You should use bisoprolol fumarate and hydrochlorothiazide during pregnancy only if the potential benefits outweigh the risks to your fetus. This medication should be used during pregnancy only if it is clearly necessary. If you are pregnant, the use of thiazides requires that you and your healthcare provider weigh the anticipated benefits against any possible risks to your fetus. Side Effects You may experience bradycardia. You might notice arrhythmia. Peripheral ischemia could occur. Chest pain may be a possibility. Bronchospasm might happen. Coughing could be a side effect. You may have rhinitis. Upper respiratory infections (URI) could occur. Asthenia may affect you. Fatigue might be experienced. You could have peripheral edema. Dizziness may be a concern. Headaches could occur. Muscle cramps might happen. You may experience myalgia. Insomnia could affect you. Somnolence might be a side effect. You may notice a loss of libido. Impotence could occur. Diarrhea might be experienced. Nausea may affect you. Dyspepsia could occur. You might feel weakness. Vertigo may be a possibility. Paresthesia could happen. Restlessness might affect you. Orthostatic hypotension may occur. Anorexia could be a concern. Gastric irritation might happen. Cramping may affect you. Jaundice (intrahepatic cholestatic jaundice) could occur. Pancreatitis might be a possibility. Cholecystitis could happen. Sialadenitis may affect you. You might experience dry mouth. Muscle spasms could occur. Purpura may be a concern. Photosensitivity might happen. You may notice a rash. Urticaria could occur. Necrotizing angiitis (vasculitis and cutaneous vasculitis) might happen. Fever may affect you. Respiratory distress, including pneumonitis and pulmonary edema, could occur. Anaphylactic reactions might happen. You may experience transient blurred vision. Choroidal effusion could occur. Xanthopsia might be a possibility. Sexual dysfunction may affect you. Renal failure could occur. Renal dysfunction might happen. Interstitial nephritis may be a concern. Erythema multiforme, including Stevens-Johnson syndrome, could occur. Exfoliative dermatitis, including toxic epidermal necrolysis, might happen. Hyperglycemia may affect you. Glycosuria could occur. Hyperuricemia might be a possibility. Hypokalemia may be a concern. Hyperlipidemia could happen. Hypercalcemia might occur. Leukopenia may affect you. Agranulocytosis could occur. Thrombocytopenia might happen. Aplastic anemia may be a concern. Hemolytic anemia could occur. Acute angle-closure glaucoma might happen. Elevated intraocular pressure may affect you. You might experience ocular pain. Warnings beta-blocking agents should be avoided in patients with overt congestive failure continued depression of the myocardium with beta-blockers can precipitate cardiac failure at the first signs or symptoms of heart failure, discontinuation of bisoprolol fumarate and hydrochlorothiazide should be considered exacerbations of angina pectoris and, in some instances, myocardial infarction or ventricular arrhythmia, have been observed in patients with coronary artery disease following abrupt cessation of therapy with beta-blockers patients should be cautioned against interruption or discontinuation of therapy without the physician's advice caution should be exercised in patients with peripheral vascular disease as beta-blockers can precipitate or aggravate symptoms of arterial insufficiency patients with bronchospastic pulmonary disease should, in general, not receive beta-blockers the lowest possible dose of bisoprolol fumarate and hydrochlorothiazide should be used in patients with bronchospastic disease a beta agonist (bronchodilator) should be made available for patients with bronchospastic disease chronically administered beta-blocking therapy should not be routinely withdrawn prior to major surgery beta-blockers may prevent early warning signs of hypoglycemia, such as tachycardia patients with diabetes mellitus or children and patients who are fasting are at increased risk for severe or prolonged hypoglycemia if severe hypoglycemia occurs, patients should be instructed to seek emergency treatment beta-adrenergic blockade may mask clinical signs of hyperthyroidism abrupt withdrawal of beta-blockade may be followed by an exacerbation of the symptoms of hyperthyroidism or may precipitate thyroid storm cumulative effects of the thiazides may develop in patients with impaired renal function if progressive renal impairment becomes apparent, bisoprolol fumarate and hydrochlorothiazide should be discontinued bisoprolol fumarate and hydrochlorothiazide should be used with caution in patients with impaired hepatic function or progressive liver disease hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute angle-closure glaucoma and elevated intraocular pressure risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy patients with a history of severe anaphylactic reaction to a variety of allergens may be more reactive to repeated challenge while taking beta-blockers patients may be unresponsive to the usual doses of epinephrine used to treat allergic reactions patients receiving thiazides may experience sensitivity reactions with or without a history of allergy or bronchial asthma Pregnancy & Lactation bisoprolol fumarate and hydrochlorothiazide should be used during pregnancy only if the potential benefit justifies the risk to the fetus this drug should be used during pregnancy only if clearly needed the use of thiazides in pregnant women requires that the anticipated benefit be weighed against possible hazards to the fetus Side Effects bradycardia arrhythmia peripheral ischemia chest pain bronchospasm cough rhinitis URI asthenia fatigue peripheral edema dizziness headache muscle cramps myalgia insomnia somnolence loss of libido impotence diarrhea nausea dyspepsia weakness vertigo paresthesia restlessness orthostatic hypotension anorexia gastric irritation cramping jaundice (intrahepatic cholestatic jaundice) pancreatitis cholecystitis sialadenitis dry mouth muscle spasm purpura photosensitivity rash urticaria necrotizing angiitis (vasculitis and cutaneous vasculitis) fever respiratory distress including pneumonitis and pulmonary edema anaphylactic reactions transient blurred vision choroidal effusion xanthopsia sexual dysfunction renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis hyperglycemia glycosuria hyperuricemia hypokalemia hyperlipidemia hypercalcemia leukopenia agranulocytosis thrombocytopenia aplastic anemia hemolytic anemia acute angle-closure glaucoma elevated intraocular pressure ocular pain
Bisoprolol Fumarate and Hydrochlorothiazide Rx tablet ANI Pharmaceuticals, Inc.	Popularity – score 0 out of 100 (least-viewed drug)	21 warnings	4 pregnancy and lactation warnings	102 side effects	Trend: rose 40% over the year; peak in Sep.
Bisoprolol Fumarate and Hydrochlorothiazide® · First marketed 2021 · Label last revised March 14, 2024View full label details → Warnings You should avoid beta-blocking agents if you have overt congestive failure. Consider stopping bisoprolol fumarate and hydrochlorothiazide tablets at the first signs or symptoms of heart failure. If you have coronary artery disease, be cautious about interrupting or stopping therapy without your physician’s advice. It may be advisable for you to taper therapy with bisoprolol fumarate and hydrochlorothiazide tablets over approximately 1 week while under careful observation. Beta-blockers can worsen symptoms of arterial insufficiency if you have peripheral vascular disease. In general, you should not receive beta-blockers if you have bronchospastic pulmonary disease. If you have bronchospastic disease, the lowest possible dose of bisoprolol fumarate and hydrochlorothiazide tablets should be used. You should seek emergency treatment if you experience severe hypoglycemia. If you have latent diabetes mellitus, it may become apparent, and you may need to adjust your insulin dose if you are given thiazides. Beta-adrenergic blockade may mask clinical signs of hyperthyroidism. If you notice progressive renal impairment, bisoprolol fumarate and hydrochlorothiazide tablets should be discontinued. Use bisoprolol fumarate and hydrochlorothiazide tablets with caution if you have impaired hepatic function or progressive liver disease. Hydrochlorothiazide can cause an idiosyncratic reaction, leading to acute angle-closure glaucoma. If you are taking hydrochlorothiazide, protect your skin from the sun and undergo regular skin cancer screenings. Consult your healthcare provider immediately if you experience visual field defects, decreased visual acuity, or ocular pain while taking hydrochlorothiazide. If you have a history of severe anaphylactic reactions, you may be more reactive to repeated challenges while taking beta-blockers. If you are receiving thiazides, you should be observed closely to determine if the desired effect of the diuretic is achieved. Sensitivity reactions may occur with or without a history of allergy or bronchial asthma if you are receiving thiazides. If you are pregnant, the use of thiazides requires weighing the anticipated benefit against possible hazards to the fetus. You should decide whether to discontinue nursing or the drug, considering the importance of the drug to you. The safety and effectiveness of bisoprolol fumarate and hydrochlorothiazide tablets in children have not been established. Pregnancy & Lactation You should decide whether to stop nursing or to discontinue the drug, considering how important the medication is for you. You should use bisoprolol fumarate and hydrochlorothiazide tablets during pregnancy only if the potential benefits outweigh the risks to your baby. This drug should only be used during pregnancy if it is clearly necessary for your health. If you are pregnant, using thiazides requires weighing the expected benefits against any possible risks to your baby. Side Effects You may experience bradycardia. You might notice arrhythmia. Peripheral ischemia could occur. Chest pain may be a possibility. Bronchospasm might happen. Coughing could be a side effect. You may have rhinitis. Upper respiratory infections (URI) can occur. Asthenia may affect you. Fatigue might be experienced. Peripheral edema could develop. Dizziness may be a concern. Headaches might occur. Muscle cramps could happen. You may experience myalgia. Insomnia might affect your sleep. Somnolence could occur. You may notice a loss of libido. Impotence might be a possibility. Diarrhea could occur. Nausea may affect you. Dyspepsia might be experienced. Unsteadiness could happen. You may feel vertigo. Syncope might occur. Paresthesia could develop. Hypoesthesia may affect your sensation. You might experience hyperesthesia. Sleep disturbances or vivid dreams could occur. Depression may affect you. Anxiety or restlessness might be experienced. You may notice decreased concentration or memory. Palpitations and other rhythm disturbances could occur. Cold extremities might be a concern. Claudication may affect you. Hypotension could occur. Orthostatic hypotension might happen. Congestive heart failure is a potential risk. You may experience dyspnea on exertion. Gastric, epigastric, or abdominal pain could occur. Peptic ulcers might develop. Gastritis may affect you. Vomiting could happen. Constipation might be a concern. You may experience dry mouth. Arthralgia could occur. Muscle or joint pain might affect you. Back or neck pain could develop. Twitching or tremors may occur. You might notice a rash. Acne could develop. Eczema may affect your skin. Psoriasis might occur. Skin irritation could happen. You may experience pruritus. Purpura might develop. Flushing could occur. Sweating may be a side effect. Alopecia might affect you. Dermatitis could occur. Exfoliative dermatitis is very rare but possible. You may experience cutaneous vasculitis. Visual disturbances might occur. Ocular pain or pressure could happen. Abnormal lacrimation may affect you. Tinnitus might be experienced. Decreased hearing could occur. You may have earache. Taste abnormalities might develop. Gout could be a concern. Weakness may affect you. Orthostatic hypotension may be worsened by alcohol, barbiturates, or narcotics. Anorexia might occur. Gastric irritation could happen. Cramping may affect you. Jaundice (intrahepatic cholestatic jaundice) could occur. Pancreatitis might develop. Cholecystitis may affect you. Sialadenitis could occur. You may experience dry mouth. Muscle spasms might happen. Purpura could develop. Photosensitivity may affect you. Urticaria might occur. Necrotizing angiitis (vasculitis and cutaneous vasculitis) is a rare possibility. Fever may affect you. Respiratory distress, including pneumonitis and pulmonary edema, could occur. Anaphylactic reactions might happen. Transient blurred vision could occur. Choroidal effusion may affect you. Xanthopsia might be experienced. Hyperglycemia could occur. Glycosuria may affect you. Hyperuricemia might develop. Hypokalemia and other electrolyte imbalances could occur. Hyperlipidemia may affect you. Hypercalcemia might develop. Leukopenia could occur. Agranulocytosis may be a concern. Thrombocytopenia might develop. Aplastic anemia could occur. Hemolytic anemia may affect you. Warnings beta-blocking agents should be avoided in patients with overt congestive failure discontinuation of bisoprolol fumarate and hydrochlorothiazide tablets should be considered at the first signs or symptoms of heart failure patients with coronary artery disease should be cautioned against interruption or discontinuation of therapy without the physician’s advice it may be advisable to taper therapy with bisoprolol fumarate and hydrochlorothiazide tablets over approximately 1 week with the patient under careful observation beta-blockers can precipitate or aggravate symptoms of arterial insufficiency in patients with peripheral vascular disease patients with bronchospastic pulmonary disease should, in general, not receive beta-blockers the lowest possible dose of bisoprolol fumarate and hydrochlorothiazide tablets should be used in patients with bronchospastic disease patients should be instructed to seek emergency treatment if severe hypoglycemia occurs latent diabetes mellitus may become manifest and diabetic patients given thiazides may require adjustment of their insulin dose beta-adrenergic blockade may mask clinical signs of hyperthyroidism if progressive renal impairment becomes apparent, bisoprolol fumarate and hydrochlorothiazide tablets should be discontinued bisoprolol fumarate and hydrochlorothiazide tablets should be used with caution in patients with impaired hepatic function or progressive liver disease hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute angle-closure glaucoma patients taking hydrochlorothiazide should protect skin from the sun and undergo regular skin cancer screening patients taking hydrochlorothiazide should immediately consult their healthcare provider if visual field defects, decreased visual acuity, or ocular pain occur patients with a history of severe anaphylactic reaction may be more reactive to repeated challenge while taking beta-blockers patients receiving thiazides should be observed closely to determine if the desired effect of the diuretic is obtained sensitivity reactions may occur with or without a history of allergy or bronchial asthma in patients receiving thiazides the use of thiazides in pregnant women requires that the anticipated benefit be weighed against possible hazards to the fetus a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother safety and effectiveness of bisoprolol fumarate and hydrochlorothiazide tablets in pediatric patients have not been established Pregnancy & Lactation a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother bisoprolol fumarate and hydrochlorothiazide tablets should be used during pregnancy only if the potential benefit justifies the risk to the fetus this drug should be used during pregnancy only if clearly needed the use of thiazides in pregnant women requires that the anticipated benefit be weighed against possible hazards to the fetus Side Effects bradycardia arrhythmia peripheral ischemia chest pain bronchospasm cough rhinitis URI asthenia fatigue peripheral edema dizziness headache muscle cramps myalgia insomnia somnolence loss of libido impotence diarrhea nausea dyspepsia unsteadiness vertigo syncope paresthesia hypoesthesia hyperesthesia sleep disturbance/vivid dreams depression anxiety/restlessness decreased concentration/memory palpitations and other rhythm disturbances cold extremities claudication hypotension orthostatic hypotension congestive heart failure dyspnea on exertion gastric/epigastric/abdominal pain peptic ulcer gastritis vomiting constipation dry mouth arthralgia muscle/joint pain back/neck pain twitching/tremor rash acne eczema psoriasis skin irritation pruritus purpura flushing sweating alopecia dermatitis exfoliative dermatitis (very rarely) cutaneous vasculitis visual disturbances ocular pain/pressure abnormal lacrimation tinnitus decreased hearing earache taste abnormalities gout weakness orthostatic hypotension (may be potentiated by alcohol, barbiturates, or narcotics) anorexia gastric irritation cramping jaundice (intrahepatic cholestatic jaundice) pancreatitis cholecystitis sialadenitis dry mouth muscle spasm purpura photosensitivity urticaria necrotizing angiitis (vasculitis and cutaneous vasculitis) fever respiratory distress including pneumonitis and pulmonary edema anaphylactic reactions transient blurred vision choroidal effusion xanthopsia hyperglycemia glycosuria hyperuricemia hypokalemia and other electrolyte imbalances hyperlipidemia hypercalcemia leukopenia agranulocytosis thrombocytopenia aplastic anemia hemolytic anemia
Bisoprolol Fumarate and Hydrochlorothiazide Rx tablet, film coated GLENMARK PHARMACEUTICALS INC. , USA	Popularity – score 0 out of 100 (least-viewed drug)	24 warnings	2 pregnancy and lactation warnings	105 side effects	Trend: rose 40% over the year; peak in Sep.
Bisoprolol Fumarate and Hydrochlorothiazide® · First marketed 2022 · Label last revised January 6, 2025View full label details → Warnings You should avoid beta-blocking agents if you have overt congestive failure. At the first signs or symptoms of heart failure, you should consider discontinuing bisoprolol fumarate and hydrochlorothiazide tablets. If you have coronary artery disease, be cautious about interrupting or stopping therapy without your physician’s advice. It may be advisable for you to taper therapy with bisoprolol fumarate and hydrochlorothiazide tablets over approximately 1 week while under careful observation. Beta-blockers can worsen symptoms of arterial insufficiency if you have peripheral vascular disease. In general, you should not receive beta-blockers if you have bronchospastic pulmonary disease. You should use the lowest possible dose of bisoprolol fumarate and hydrochlorothiazide tablets. Make sure a beta agonist (bronchodilator) is available for you. If you are on chronically administered beta-blocking therapy, it should not be routinely withdrawn before major surgery. Beta-blockers may prevent early warning signs of hypoglycemia, such as tachycardia. You should seek emergency treatment if you experience severe hypoglycemia. If you have latent diabetes mellitus, it may become apparent, and you may need to adjust your insulin dose if you are given thiazides. Beta-adrenergic blockade may mask clinical signs of hyperthyroidism for you. If you notice progressive renal impairment, bisoprolol fumarate and hydrochlorothiazide tablets should be discontinued. Use bisoprolol fumarate and hydrochlorothiazide tablets with caution if you have impaired hepatic function or progressive liver disease. Hydrochlorothiazide can cause an idiosyncratic reaction, leading to acute angle-closure glaucoma and elevated intraocular pressure. You should consult your physician if you experience any difficulty in breathing or develop other signs or symptoms of congestive heart failure or excessive bradycardia. There is a risk of hypoglycemia when bisoprolol fumarate and hydrochlorothiazide tablets are given to you if you are fasting or vomiting. You should know how you react to this medicine before operating automobiles and machinery or engaging in other tasks that require alertness. Photosensitivity reactions have been reported with thiazides. If you are taking hydrochlorothiazide, protect your skin from the sun and undergo regular skin cancer screening. If you experience visual field defects, decreased visual acuity, or ocular pain while taking hydrochlorothiazide, consult your healthcare provider immediately. A decision should be made about whether to discontinue nursing or the drug, considering the importance of the drug to you as the mother. The safety and effectiveness of bisoprolol fumarate and hydrochlorothiazide tablets in children have not been established. Pregnancy & Lactation You should use bisoprolol fumarate and hydrochlorothiazide tablets during pregnancy only if the potential benefits outweigh the risks to your fetus. If you are pregnant, the use of thiazides requires you to weigh the anticipated benefits against any possible hazards to your fetus. Side Effects You may experience bradycardia. You might notice arrhythmia. Peripheral ischemia could occur. Chest pain may be a possibility. Bronchospasm might happen. Coughing could be a side effect. You may have rhinitis. Upper respiratory infections (URI) could occur. Asthenia may affect you. You might feel fatigued. Peripheral edema could develop. Dizziness may be experienced. Headaches might occur. Muscle cramps could happen. You may experience myalgia. Insomnia might affect your sleep. Somnolence could occur. You might notice a loss of libido. Impotence may be a possibility. Diarrhea could occur. Nausea might affect you. Dyspepsia may be experienced. You might feel unsteady. Vertigo could occur. Syncope may happen. Paresthesia might be experienced. Hypoesthesia could occur. You may notice hyperesthesia. Sleep disturbances or vivid dreams might affect you. Depression could be a side effect. You might experience anxiety or restlessness. Decreased concentration or memory may occur. Palpitations and other rhythm disturbances could happen. You might notice cold extremities. Claudication may occur. Hypotension could be a possibility. Orthostatic hypotension might happen. Congestive heart failure may occur. You might experience dyspnea on exertion. Gastric, epigastric, or abdominal pain could occur. Peptic ulcers may develop. Gastritis might be a possibility. Vomiting could occur. Constipation may affect you. You might experience dry mouth. Arthralgia could occur. Muscle or joint pain may be experienced. Back or neck pain might occur. Twitching or tremors could happen. You may notice a rash. Acne might develop. Eczema could occur. Psoriasis may be a possibility. Skin irritation might happen. You may experience pruritus. Purpura could occur. Flushing might be experienced. You may notice increased sweating. Alopecia could occur. Dermatitis may be a possibility. Exfoliative dermatitis (very rarely) might happen. Cutaneous vasculitis could occur. You might experience visual disturbances. Ocular pain or pressure may occur. Abnormal lacrimation could happen. Tinnitus might be experienced. Decreased hearing may occur. You might have earache. Taste abnormalities could happen. Gout may be a possibility. Asthma might occur. Bronchitis could develop. You may experience dyspnea. Pharyngitis might happen. Sinusitis could occur. You might feel weakness. Orthostatic hypotension may be potentiated by alcohol, barbiturates, or narcotics. Anorexia could occur. Gastric irritation might happen. Cramping may be experienced. Jaundice (intrahepatic cholestatic jaundice) could occur. Pancreatitis may be a possibility. Cholecystitis might happen. Sialadenitis could occur. Muscle spasms may be experienced. Purpura might occur. Photosensitivity could happen. Necrotizing angiitis (vasculitis and cutaneous vasculitis) may occur. You might experience fever. Respiratory distress, including pneumonitis and pulmonary edema, could happen. Anaphylactic reactions may occur. Transient blurred vision might be experienced. Choroidal effusion could happen. Xanthopsia may be a possibility. Hyperglycemia might occur. Glycosuria could happen. Hyperuricemia may be experienced. Hypokalemia and other electrolyte imbalances might occur. Hyperlipidemia could happen. Hypercalcemia may be a possibility. Leukopenia might occur. Agranulocytosis could happen. Thrombocytopenia may be experienced. Aplastic anemia might occur. Hemolytic anemia could happen. Warnings beta-blocking agents should be avoided in patients with overt congestive failure at the first signs or symptoms of heart failure, discontinuation of bisoprolol fumarate and hydrochlorothiazide tablets should be considered patients with coronary artery disease should be cautioned against interruption or discontinuation of therapy without the physician’s advice it may be advisable to taper therapy with bisoprolol fumarate and hydrochlorothiazide tablets over approximately 1 week with the patient under careful observation beta-blockers can precipitate or aggravate symptoms of arterial insufficiency in patients with peripheral vascular disease patients with bronchospastic pulmonary disease should, in general, not receive beta-blockers the lowest possible dose of bisoprolol fumarate and hydrochlorothiazide tablets should be used a beta agonist (bronchodilator) should be made available chronically administered beta-blocking therapy should not be routinely withdrawn prior to major surgery beta-blockers may prevent early warning signs of hypoglycemia, such as tachycardia patients should be instructed to seek emergency treatment if severe hypoglycemia occurs latent diabetes mellitus may become manifest and diabetic patients given thiazides may require adjustment of their insulin dose beta-adrenergic blockade may mask clinical signs of hyperthyroidism if progressive renal impairment becomes apparent, bisoprolol fumarate and hydrochlorothiazide tablets should be discontinued bisoprolol fumarate and hydrochlorothiazide tablets should be used with caution in patients with impaired hepatic function or progressive liver disease hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute angle-closure glaucoma and elevated intraocular pressure patients should be advised to consult a physician if any difficulty in breathing occurs, or if they develop other signs or symptoms of congestive heart failure or excessive bradycardia there is a risk of hypoglycemia when bisoprolol fumarate and hydrochlorothiazide tablet is given to patients who are fasting or who are vomiting patients should know how they react to this medicine before they operate automobiles and machinery or engage in other tasks requiring alertness photosensitivity reactions have been reported with thiazides patients taking hydrochlorothiazide should protect skin from the sun and undergo regular skin cancer screening patients taking hydrochlorothiazide should immediately consult their healthcare provider if visual field defects, decreased visual acuity, or ocular pain occur a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother safety and effectiveness of bisoprolol fumarate and hydrochlorothiazide tablets in pediatric patients have not been established Pregnancy & Lactation bisoprolol fumarate and hydrochlorothiazide tablets should be used during pregnancy only if the potential benefit justifies the risk to the fetus the use of thiazides in pregnant women requires that the anticipated benefit be weighed against possible hazards to the fetus Side Effects bradycardia arrhythmia peripheral ischemia chest pain bronchospasm cough rhinitis URI asthenia fatigue peripheral edema dizziness headache muscle cramps myalgia insomnia somnolence loss of libido impotence diarrhea nausea dyspepsia unsteadiness vertigo syncope paresthesia hypoesthesia hyperesthesia sleep disturbance/vivid dreams depression anxiety/restlessness decreased concentration/memory palpitations and other rhythm disturbances cold extremities claudication hypotension orthostatic hypotension congestive heart failure dyspnea on exertion gastric/epigastric/abdominal pain peptic ulcer gastritis vomiting constipation dry mouth arthralgia muscle/joint pain back/neck pain twitching/tremor rash acne eczema psoriasis skin irritation pruritus purpura flushing sweating alopecia dermatitis exfoliative dermatitis (very rarely) cutaneous vasculitis visual disturbances ocular pain/pressure abnormal lacrimation tinnitus decreased hearing earache taste abnormalities gout asthma bronchitis dyspnea pharyngitis sinusitis weakness orthostatic hypotension (may be potentiated by alcohol, barbiturates, or narcotics) anorexia gastric irritation cramping jaundice (intrahepatic cholestatic jaundice) pancreatitis cholecystitis sialadenitis muscle spasm purpura photosensitivity necrotizing angiitis (vasculitis and cutaneous vasculitis) fever respiratory distress including pneumonitis and pulmonary edema anaphylactic reactions transient blurred vision choroidal effusion xanthopsia hyperglycemia glycosuria hyperuricemia hypokalemia and other electrolyte imbalances hyperlipidemia hypercalcemia leukopenia agranulocytosis thrombocytopenia aplastic anemia hemolytic anemia
Bisoprolol Fumarate and Hydrochlorothiazide Rx tablet Unichem Pharmaceuticals (USA) , Inc.	Popularity – score 0 out of 100 (least-viewed drug)	30 warnings	3 pregnancy and lactation warnings	67 side effects	Trend: rose 40% over the year; peak in Sep.
Bisoprolol Fumarate and Hydrochlorothiazide® · First marketed 2010 · Label last revised January 10, 2024View full label details → Warnings You should avoid beta-blocking agents if you have overt congestive failure. If you have compensated cardiac failure, use beta-blockers cautiously. Continued use of beta-blockers can lead to cardiac failure, so it's important to monitor your condition. At the first signs or symptoms of heart failure, consider discontinuing bisoprolol fumarate and hydrochlorothiazide. If you have coronary artery disease, do not interrupt or stop your therapy without consulting your physician. It may be advisable to taper your therapy with bisoprolol fumarate and hydrochlorothiazide over about a week while being carefully observed. If you experience withdrawal symptoms, your healthcare provider may recommend temporarily restarting beta-blocking agent therapy. Beta-blockers can worsen symptoms of arterial insufficiency if you have peripheral vascular disease. In general, you should not receive beta-blockers if you have bronchospastic pulmonary disease. If you have bronchospastic disease, the lowest possible dose of bisoprolol fumarate and hydrochlorothiazide should be used. Make sure a beta agonist (bronchodilator) is available if you have bronchospastic disease. If you are on chronic beta-blocking therapy, it should not be routinely withdrawn before major surgery. Beta-blockers may mask early warning signs of hypoglycemia, such as a rapid heartbeat. If you have diabetes mellitus, or if you are a child or fasting, you should be monitored for symptoms of hypoglycemia. If you experience severe hypoglycemia, seek emergency treatment immediately. Latent diabetes mellitus may become apparent, and if you are a diabetic patient taking thiazides, you may need to adjust your insulin dose. Beta-adrenergic blockade may hide clinical signs of hyperthyroidism, like a rapid heartbeat. Abruptly stopping beta-blockade may worsen hyperthyroidism symptoms or trigger a thyroid storm. If you have impaired renal function, be aware that cumulative effects of thiazides may develop. If you notice progressive renal impairment, bisoprolol fumarate and hydrochlorothiazide should be discontinued. Use bisoprolol fumarate and hydrochlorothiazide with caution if you have impaired hepatic function or progressive liver disease. Thiazides may disrupt fluid and electrolyte balance, potentially leading to hepatic coma. Hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute angle-closure glaucoma and elevated intraocular pressure. If you are taking hydrochlorothiazide, consult your healthcare provider immediately if you experience visual field defects, decreased visual acuity, or ocular pain. If you have a history of severe anaphylactic reactions to various allergens, you may be more reactive to repeated exposure while taking beta-blockers. If you are receiving thiazides, your healthcare provider should closely monitor you for sensitivity reactions, which can occur even without a history of allergy or bronchial asthma. Photosensitivity reactions have been reported with thiazides, so take precautions. If you are taking hydrochlorothiazide, protect your skin from the sun and have regular skin cancer screenings. The safety and effectiveness of bisoprolol fumarate and hydrochlorothiazide in pediatric patients have not been established. Be aware that some older individuals may have greater sensitivity, so monitor your response if you are a geriatric patient. Pregnancy & Lactation You should decide whether to stop nursing or to discontinue the drug, considering how important the medication is for you. You should use bisoprolol fumarate and hydrochlorothiazide during pregnancy only if the potential benefits outweigh the risks to your fetus. This drug should only be used during pregnancy if it is clearly necessary. Side Effects You may experience bradycardia. You might notice arrhythmia. Peripheral ischemia could occur. Chest pain may be a possibility. Bronchospasm can happen. You may have a cough. Rhinitis might develop. Upper respiratory infections (URI) could occur. You may feel asthenia. Fatigue is a potential side effect. Peripheral edema might be experienced. Dizziness could be a concern. Headaches may occur. Muscle cramps might happen. You may experience myalgia. Insomnia could be an issue. Somnolence may occur. You might notice a loss of libido. Impotence could be a possibility. Diarrhea may occur. Nausea might be experienced. Dyspepsia could happen. You may feel weakness. Vertigo might occur. Paresthesia could be experienced. Restlessness may be a concern. Your healthcare provider may monitor you for orthostatic hypotension. Anorexia might develop. Gastric irritation could occur. Cramping may be experienced. Jaundice (intrahepatic cholestatic jaundice) could happen. Pancreatitis may occur. Cholecystitis might be a possibility. Sialadenitis could develop. You may experience dry mouth. Muscle spasms might occur. Purpura could be a concern. Photosensitivity may happen. You might notice a rash. Urticaria could develop. Necrotizing angiitis (vasculitis and cutaneous vasculitis) may occur. Fever might be experienced. Respiratory distress, including pneumonitis and pulmonary edema, could happen. Anaphylactic reactions may occur. You might experience transient blurred vision. Choroidal effusion could be a possibility. Xanthopsia may occur. Gout might develop. Sexual dysfunction could be a concern. Renal failure may occur. Renal dysfunction might happen. Interstitial nephritis could develop. Erythema multiforme, including Stevens-Johnson syndrome, may occur. Exfoliative dermatitis, including toxic epidermal necrolysis, could happen. Hyperglycemia might be a concern. Glycosuria may occur. Hyperuricemia could develop. Hypokalemia might happen. Electrolyte imbalances may occur. Hyperlipidemia could be a possibility. Hypercalcemia might develop. Leukopenia may occur. Agranulocytosis could happen. Thrombocytopenia might be a concern. Aplastic anemia may occur. Hemolytic anemia could develop. Non-melanoma skin cancer might be a possibility. Warnings beta-blocking agents should be avoided in patients with overt congestive failure in some patients with compensated cardiac failure, beta-blockers must be used cautiously continued depression of the myocardium with beta-blockers can precipitate cardiac failure at the first signs or symptoms of heart failure, discontinuation of bisoprolol fumarate and hydrochlorothiazide should be considered patients with coronary artery disease should be cautioned against interruption or discontinuation of therapy without the physician’s advice it may be advisable to taper therapy with bisoprolol fumarate and hydrochlorothiazide over approximately 1 week with the patient under careful observation if withdrawal symptoms occur, beta-blocking agent therapy should be reinstituted, at least temporarily beta-blockers can precipitate or aggravate symptoms of arterial insufficiency in patients with peripheral vascular disease patients with bronchospastic pulmonary disease should, in general, not receive beta-blockers the lowest possible dose of bisoprolol fumarate and hydrochlorothiazide should be used in patients with bronchospastic disease a beta agonist (bronchodilator) should be made available for patients with bronchospastic disease chronically administered beta-blocking therapy should not be routinely withdrawn prior to major surgery beta-blockers may prevent early warning signs of hypoglycemia, such as tachycardia patients with diabetes mellitus or children and patients who are fasting should be monitored for symptoms of hypoglycemia if severe hypoglycemia occurs, patients should be instructed to seek emergency treatment latent diabetes mellitus may become manifest and diabetic patients given thiazides may require adjustment of their insulin dose beta-adrenergic blockade may mask clinical signs of hyperthyroidism, such as tachycardia abrupt withdrawal of beta-blockade may be followed by an exacerbation of the symptoms of hyperthyroidism or may precipitate thyroid storm cumulative effects of the thiazides may develop in patients with impaired renal function if progressive renal impairment becomes apparent, bisoprolol fumarate and hydrochlorothiazide should be discontinued bisoprolol fumarate and hydrochlorothiazide should be used with caution in patients with impaired hepatic function or progressive liver disease thiazides may alter fluid and electrolyte balance, which may precipitate hepatic coma hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute angle-closure glaucoma and elevated intraocular pressure patients taking hydrochlorothiazide should immediately consult their healthcare provider if visual field defects, decreased visual acuity, or ocular pain occur patients with a history of severe anaphylactic reaction to a variety of allergens may be more reactive to repeated challenge while taking beta-blockers patients receiving thiazides should be observed closely for sensitivity reactions, which may occur with or without a history of allergy or bronchial asthma photosensitivity reactions have been reported with thiazides patients taking hydrochlorothiazide should protect skin from the sun and undergo regular skin cancer screening safety and effectiveness of bisoprolol fumarate and hydrochlorothiazide in pediatric patients have not been established greater sensitivity of some older individuals cannot be ruled out in geriatric patients Pregnancy & Lactation a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother bisoprolol fumarate and hydrochlorothiazide should be used during pregnancy only if the potential benefit justifies the risk to the fetus this drug should be used during pregnancy only if clearly needed Side Effects bradycardia arrhythmia peripheral ischemia chest pain bronchospasm cough rhinitis URI asthenia fatigue peripheral edema dizziness headache muscle cramps myalgia insomnia somnolence loss of libido impotence diarrhea nausea dyspepsia weakness vertigo paresthesia restlessness orthostatic hypotension anorexia gastric irritation cramping jaundice (intrahepatic cholestatic jaundice) pancreatitis cholecystitis sialadenitis dry mouth muscle spasm purpura photosensitivity rash urticaria necrotizing angiitis (vasculitis and cutaneous vasculitis) fever respiratory distress including pneumonitis and pulmonary edema anaphylactic reactions transient blurred vision choroidal effusion xanthopsia gout sexual dysfunction renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis hyperglycemia glycosuria hyperuricemia hypokalemia electrolyte imbalances hyperlipidemia hypercalcemia leukopenia agranulocytosis thrombocytopenia aplastic anemia hemolytic anemia non-melanoma skin cancer
Bisoprolol Fumarate and Hydrochlorothiazide Rx tablet, film coated Mylan Pharmaceuticals Inc.	Popularity – score 0 out of 100 (least-viewed drug)	27 warnings	4 pregnancy and lactation warnings	0 side effects	Trend: rose 40% over the year; peak in Sep.
Bisoprolol Fumarate and Hydrochlorothiazide® · First marketed 2021 · Label last revised April 17, 2024View full label details → Warnings You should avoid beta-blocking agents if you have overt congestive failure. Continued depression of the myocardium with beta-blockers can, in some cases, lead to cardiac failure. At the first signs or symptoms of heart failure, you should consider discontinuing bisoprolol fumarate and hydrochlorothiazide tablets. If you have coronary artery disease, be aware that abrupt cessation of therapy with beta-blockers may lead to exacerbations of angina pectoris, and in some instances, myocardial infarction or ventricular arrhythmia. Please do not interrupt or discontinue your therapy without consulting your physician. Exercise caution if you have peripheral vascular disease. In general, you should not receive beta-blockers if you have bronchospastic pulmonary disease. The lowest possible dose of bisoprolol fumarate and hydrochlorothiazide tablets should be used if you have bronchospastic disease. Make sure a beta agonist (bronchodilator) is available if you have bronchospastic disease. If you are on chronically administered beta-blocking therapy, it should not be routinely withdrawn prior to major surgery. Be aware that beta-blockers may prevent early warning signs of hypoglycemia, such as tachycardia. You should seek emergency treatment if you experience severe hypoglycemia. If you have latent diabetes mellitus, it may become apparent, and you may need to adjust your insulin dose if you are given thiazides. Beta-adrenergic blockade may mask clinical signs of hyperthyroidism, such as tachycardia. Abrupt withdrawal of beta-blockade may lead to an exacerbation of hyperthyroidism symptoms or may precipitate a thyroid storm. Cumulative effects of thiazides may develop if you have impaired renal function. Thiazides may cause azotemia if you have impaired renal function. You should discontinue bisoprolol fumarate and hydrochlorothiazide tablets if progressive renal impairment becomes apparent. Use bisoprolol fumarate and hydrochlorothiazide tablets with caution if you have impaired hepatic function or progressive liver disease. Thiazides may alter fluid and electrolyte balance, which could lead to hepatic coma. Hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute angle-closure glaucoma and elevated intraocular pressure. If you experience symptoms of acute angle-closure glaucoma, you should discontinue hydrochlorothiazide as quickly as possible. Consult your physician if you have any difficulty breathing or develop other signs or symptoms of congestive heart failure or excessive bradycardia. You should know how this medicine affects you before operating automobiles and machinery or engaging in tasks that require alertness. Photosensitivity reactions have been reported with thiazides. If you are taking hydrochlorothiazide, protect your skin from the sun and undergo regular skin cancer screenings. If you experience visual field defects, decreased visual acuity, or ocular pain while taking hydrochlorothiazide, consult your healthcare provider immediately. Pregnancy & Lactation You should use bisoprolol fumarate and hydrochlorothiazide tablets during pregnancy only if the potential benefits outweigh the risks to your fetus. This medication should be used during pregnancy only if it is clearly necessary. If you are pregnant, the use of thiazides requires weighing the anticipated benefits against any possible risks to your fetus. Due to the potential for serious adverse reactions in nursing infants, you should decide whether to continue nursing or to stop the medication, considering how important the drug is for your health. Side Effects You may experience bradycardia. You might notice arrhythmia. Peripheral ischemia could occur. Chest pain may be a possibility. Bronchospasm might happen. You could have a cough. Rhinitis may develop. You might experience an upper respiratory infection (URI). Asthenia could be a concern. Fatigue may affect you. Peripheral edema might occur. Dizziness could be experienced. You may have a headache. Muscle cramps might happen. You could experience myalgia. Insomnia may affect you. Somnolence might occur. You may notice a loss of libido. Impotence could be a possibility. Diarrhea may occur. Nausea might affect you. Dyspepsia could be experienced. You may feel weakness. Vertigo might occur. Paresthesia could be a concern. Restlessness may affect you. Your healthcare provider may monitor you for orthostatic hypotension. Anorexia might develop. Gastric irritation could occur. Cramping may be experienced. You might have constipation. Jaundice could be a possibility. Pancreatitis may occur. Cholecystitis might develop. Sialadenitis could be a concern. You may experience dry mouth. Muscle spasms might happen. Purpura could occur. Photosensitivity may affect you. You might notice a rash. Urticaria could develop. Necrotizing angiitis might be a possibility. You may experience fever. Respiratory distress could occur. Anaphylactic reactions might happen. You may notice transient blurred vision. Choroidal effusion could occur. Xanthopsia might be experienced. Gout may develop. You could experience sexual dysfunction. Renal failure might occur. Renal dysfunction could be a concern. Interstitial nephritis may develop. Erythema multiforme might occur. Stevens-Johnson syndrome could be a possibility. Exfoliative dermatitis may affect you. Toxic epidermal necrolysis might occur. You may experience hyperglycemia. Glycosuria could develop. Hyperuricemia might be a concern. Hypokalemia may occur. Electrolyte imbalances could happen. Hyperlipidemia might develop. Hypercalcemia may be a possibility. Leukopenia could occur. Agranulocytosis might happen. Thrombocytopenia may develop. Aplastic anemia could be a concern. Hemolytic anemia might occur. Warnings beta-blocking agents should be avoided in patients with overt congestive failure continued depression of the myocardium with beta-blockers can, in some patients, precipitate cardiac failure at the first signs or symptoms of heart failure, discontinuation of bisoprolol fumarate and hydrochlorothiazide tablets should be considered exacerbations of angina pectoris and, in some instances, myocardial infarction or ventricular arrhythmia, have been observed in patients with coronary artery disease following abrupt cessation of therapy with beta-blockers patients should be cautioned against interruption or discontinuation of therapy without the physician’s advice caution should be exercised in patients with peripheral vascular disease patients with bronchospastic pulmonary disease should, in general, not receive beta-blockers the lowest possible dose of bisoprolol fumarate and hydrochlorothiazide tablets should be used in patients with bronchospastic disease a beta agonist (bronchodilator) should be made available for patients with bronchospastic disease chronically administered beta-blocking therapy should not be routinely withdrawn prior to major surgery beta-blockers may prevent early warning signs of hypoglycemia, such as tachycardia patients should be instructed to seek emergency treatment if severe hypoglycemia occurs latent diabetes mellitus may become manifest and diabetic patients given thiazides may require adjustment of their insulin dose beta-adrenergic blockade may mask clinical signs of hyperthyroidism, such as tachycardia abrupt withdrawal of beta-blockade may be followed by an exacerbation of the symptoms of hyperthyroidism or may precipitate thyroid storm cumulative effects of the thiazides may develop in patients with impaired renal function thiazides may precipitate azotemia in patients with impaired renal function bisoprolol fumarate and hydrochlorothiazide tablets should be discontinued if progressive renal impairment becomes apparent bisoprolol fumarate and hydrochlorothiazide tablets should be used with caution in patients with impaired hepatic function or progressive liver disease thiazides may alter fluid and electrolyte balance, which may precipitate hepatic coma hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute angle-closure glaucoma and elevated intraocular pressure patients should be instructed to discontinue hydrochlorothiazide as rapidly as possible if symptoms of acute angle-closure glaucoma occur patients should be advised to consult a physician if any difficulty in breathing occurs, or if they develop other signs or symptoms of congestive heart failure or excessive bradycardia patients should know how they react to this medicine before they operate automobiles and machinery or engage in other tasks requiring alertness photosensitivity reactions have been reported with thiazides patients taking hydrochlorothiazide should protect skin from the sun and undergo regular skin cancer screening patients taking hydrochlorothiazide should immediately consult their healthcare provider if visual field defects, decreased visual acuity, or ocular pain occur Pregnancy & Lactation bisoprolol fumarate and hydrochlorothiazide tablets should be used during pregnancy only if the potential benefit justifies the risk to the fetus this drug should be used during pregnancy only if clearly needed the use of thiazides in pregnant women requires that the anticipated benefit be weighed against possible hazards to the fetus because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother Side Effects No side effects reported.
Bisoprolol Fumarate and Hydrochlorothiazide Rx tablet Marlex Pharmaceuticals, Inc.	Popularity – score 0 out of 100 (least-viewed drug)	17 warnings	5 pregnancy and lactation warnings	98 side effects	Trend: rose 40% over the year; peak in Sep.
Bisoprolol Fumarate and Hydrochlorothiazide® · First marketed 2022 · Label last revised September 23, 2025View full label details → Warnings You should avoid beta-blocking agents if you have overt congestive failure. At the first signs or symptoms of heart failure, consider discontinuing bisoprolol fumarate and hydrochlorothiazide tablets. If you have coronary artery disease, be cautious about interrupting or stopping therapy without your physician’s advice. You should taper therapy with bisoprolol fumarate and hydrochlorothiazide tablets over approximately 1 week while being carefully observed. Beta-blockers can worsen symptoms of arterial insufficiency if you have peripheral vascular disease. In general, you should not receive beta-blockers if you have bronchospastic disease. If you experience spontaneous hypoglycemia or are a diabetic patient taking insulin or oral hypoglycemic agents, be aware that beta-blockers may mask some signs of hypoglycemia. Be cautious that abruptly stopping beta-blockade may lead to worsening symptoms of hyperthyroidism or trigger a thyroid storm. If you have impaired renal function, thiazides may cause azotemia. Use bisoprolol fumarate and hydrochlorothiazide tablets with caution if you have impaired hepatic function or progressive liver disease. Hydrochlorothiazide can cause an idiosyncratic reaction, leading to acute angle-closure glaucoma and elevated intraocular pressure. If you have a history of severe anaphylactic reactions to various allergens, you may be more reactive to repeated challenges while taking beta-blockers. You should understand how this medicine affects you before operating automobiles and machinery or engaging in tasks that require alertness. Photosensitivity reactions have been reported with thiazides. If you are taking hydrochlorothiazide, protect your skin from the sun and undergo regular skin cancer screenings. If you experience visual field defects, decreased visual acuity, or ocular pain while taking hydrochlorothiazide, consult your healthcare provider immediately. You should decide whether to continue nursing or discontinue the drug, considering the importance of the medication to you. Pregnancy & Lactation You should use bisoprolol fumarate and hydrochlorothiazide tablets during pregnancy only if the potential benefits outweigh the risks to your fetus. If you are pregnant, the use of thiazides requires weighing the anticipated benefits against possible risks to your fetus. There are no adequate and well-controlled studies of bisoprolol fumarate and hydrochlorothiazide tablets in pregnant women. You will need to decide whether to continue nursing or to stop taking the drug, considering how important the medication is for you. Small amounts of bisoprolol fumarate have been found in the milk of lactating rats. Side Effects You may experience bradycardia. You might notice arrhythmia. Peripheral ischemia could occur. Chest pain may be a possibility. Bronchospasm might happen. You could have a cough. Rhinitis may develop. You might experience an upper respiratory infection (URI). Asthenia could be a concern. Fatigue may affect you. Peripheral edema might occur. Dizziness could be experienced. You may have headaches. Muscle cramps might happen. You could experience myalgia. Insomnia may affect you. Somnolence might occur. You may notice a loss of libido. Impotence could be a possibility. Diarrhea may occur. Nausea might affect you. Dyspepsia could be experienced. You might feel unsteady. Vertigo may occur. Syncope could happen. Paresthesia might be experienced. You may notice hypoesthesia. Hyperesthesia could occur. You might experience sleep disturbances or vivid dreams. Depression may affect you. Anxiety or restlessness could occur. You might notice decreased concentration or memory. Palpitations and other rhythm disturbances may happen. Cold extremities could be a concern. Claudication might occur. Hypotension may affect you. Orthostatic hypotension could happen. Congestive heart failure may be a risk. You might experience dyspnea on exertion. Gastric, epigastric, or abdominal pain could occur. Peptic ulcers may develop. Gastritis might be a concern. You may experience vomiting. Constipation could occur. Dry mouth might affect you. You may experience arthralgia. Muscle or joint pain could happen. Back or neck pain might occur. Twitching or tremors may be experienced. You might notice a rash. Acne could develop. Eczema may be a possibility. Psoriasis might occur. Skin irritation could happen. You may experience pruritus. Purpura might be a concern. Flushing could occur. Sweating may affect you. Alopecia might happen. Dermatitis could occur. Exfoliative dermatitis may be a possibility. Cutaneous vasculitis might occur. You may experience visual disturbances. Ocular pain or pressure could happen. Abnormal lacrimation might occur. Tinnitus may affect you. You might notice decreased hearing. Earache could be a concern. Taste abnormalities may occur. Gout might develop. You may experience asthma. Bronchitis could occur. Dyspnea might happen. Pharyngitis may affect you. Sinusitis could be a possibility. You might feel weakness. Orthostatic hypotension may occur. Muscle spasms could happen. Purpura might be experienced. Photosensitivity may affect you. Necrotizing angiitis could occur. You may experience fever. Respiratory distress might happen. Anaphylactic reactions could be a risk. Transient blurred vision may occur. Choroidal effusion might happen. You may notice xanthopsia. Hyperglycemia could be a concern. Glycosuria might occur. Hyperuricemia may affect you. Hypokalemia could happen. Leukopenia might be a possibility. Agranulocytosis may occur. Thrombocytopenia could happen. Aplastic anemia might be a concern. Hemolytic anemia may occur. Mesenteric arterial thrombosis could happen. Ischemic colitis might be experienced. Warnings beta-blocking agents should be avoided in patients with overt congestive failure at the first signs or symptoms of heart failure, discontinuation of bisoprolol fumarate and hydrochlorothiazide tablets should be considered patients with coronary artery disease should be cautioned against interruption or discontinuation of therapy without the physician’s advice patients should be advised to taper therapy with bisoprolol fumarate and hydrochlorothiazide tablets over approximately 1 week with the patient under careful observation beta-blockers can precipitate or aggravate symptoms of arterial insufficiency in patients with peripheral vascular disease patients with bronchospastic disease should, in general, not receive beta-blockers patients subject to spontaneous hypoglycemia, or diabetic patients receiving insulin or oral hypoglycemic agents, should be cautioned about the possibilities of beta-blockers masking some manifestations of hypoglycemia patients should be cautioned that abrupt withdrawal of beta-blockade may be followed by an exacerbation of the symptoms of hyperthyroidism or may precipitate thyroid storm in patients with impaired renal function, thiazides may precipitate azotemia bisoprolol fumarate and hydrochlorothiazide tablets should be used with caution in patients with impaired hepatic function or progressive liver disease hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute angle-closure glaucoma and elevated intraocular pressure patients with a history of severe anaphylactic reaction to a variety of allergens may be more reactive to repeated challenge while taking beta-blockers patients should know how they react to this medicine before they operate automobiles and machinery or engage in other tasks requiring alertness photosensitivity reactions have been reported with thiazides patients taking hydrochlorothiazide should protect skin from the sun and undergo regular skin cancer screening patients taking hydrochlorothiazide should immediately consult their healthcare provider if visual field defects, decreased visual acuity, or ocular pain occur a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother Pregnancy & Lactation bisoprolol fumarate and hydrochlorothiazide tablets should be used during pregnancy only if the potential benefit justifies the risk to the fetus the use of thiazides in pregnant women requires that the anticipated benefit be weighed against possible hazards to the fetus there are no adequate and well-controlled studies with bisoprolol fumarate and hydrochlorothiazide tablets in pregnant women a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother small amounts of bisoprolol fumarate have been detected in the milk of lactating rats Side Effects bradycardia arrhythmia peripheral ischemia chest pain bronchospasm cough rhinitis URI asthenia fatigue peripheral edema dizziness headache muscle cramps myalgia insomnia somnolence loss of libido impotence diarrhea nausea dyspepsia unsteadiness vertigo syncope paresthesia hypoesthesia hyperesthesia sleep disturbance/vivid dreams depression anxiety/restlessness decreased concentration/memory palpitations and other rhythm disturbances cold extremities claudication hypotension orthostatic hypotension congestive heart failure dyspnea on exertion gastric/epigastric/abdominal pain peptic ulcer gastritis vomiting constipation dry mouth arthralgia muscle/joint pain back/neck pain twitching/tremor rash acne eczema psoriasis skin irritation pruritus purpura flushing sweating alopecia dermatitis exfoliative dermatitis cutaneous vasculitis visual disturbances ocular pain/pressure abnormal lacrimation tinnitus decreased hearing earache taste abnormalities gout asthma bronchitis dyspnea pharyngitis sinusitis weakness orthostatic hypotension muscle spasm purpura photosensitivity necrotizing angiitis fever respiratory distress anaphylactic reactions transient blurred vision choroidal effusion xanthopsia hyperglycemia glycosuria hyperuricemia hypokalemia leukopenia agranulocytosis thrombocytopenia aplastic anemia hemolytic anemia mesenteric arterial thrombosis ischemic colitis
Candesartan Cilexetil and Hydrochlorothiazide Rx tablet Solco Healthcare LLC	Popularity – score 0 out of 100 (least-viewed drug)	28 warnings	1 pregnancy and lactation warnings	53 side effects	Trend: fell 33% over the year; peaks in May, Aug, Sep.
Candesartan Cilexetil and Hydrochlorothiazide® · First marketed 2017 · Label last revised May 21, 2021View full label details → Warnings If you find out you are pregnant, please stop taking candesartan cilexetil and hydrochlorothiazide tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm your developing fetus. If you experience symptomatic hypotension, you may need to temporarily reduce your dose of candesartan cilexetil and hydrochlorothiazide tablets or receive volume repletion. Make sure to correct any volume and/or salt depletion before starting therapy with candesartan cilexetil and hydrochlorothiazide tablets. Your healthcare provider will periodically check your renal function while you are on candesartan cilexetil and hydrochlorothiazide tablets. If you experience a significant decrease in renal function while taking candesartan cilexetil and hydrochlorothiazide tablets, your healthcare provider may consider withholding or stopping the therapy. Medications that inhibit the renin-angiotensin system can lead to high potassium levels in your blood. Hydrochlorothiazide may cause low potassium and low sodium levels. Your healthcare provider will periodically monitor your serum electrolytes. Hydrochlorothiazide can cause acute transient myopia and acute angle-closure glaucoma. If acute angle-closure glaucoma is left untreated, it can result in permanent vision loss. You may experience hypersensitivity reactions to hydrochlorothiazide, even if you do not have a history of allergies or bronchial asthma. If you are a female of childbearing age, it’s important to understand the risks of taking candesartan cilexetil and hydrochlorothiazide tablets during pregnancy. Be aware that lightheadedness can occur, especially during the first few days of taking candesartan cilexetil and hydrochlorothiazide tablets. If you experience syncope, please stop taking candesartan cilexetil and hydrochlorothiazide tablets until you consult your physician. Inadequate fluid intake, excessive sweating, diarrhea, or vomiting can lead to a significant drop in blood pressure. Do not use potassium supplements, salt substitutes containing potassium, or other medications that may raise your serum potassium levels without consulting your prescribing physician. If you are taking hydrochlorothiazide, remember to protect your skin from the sun and have regular skin cancer screenings. Your healthcare provider will periodically monitor your renal function if you are receiving candesartan and NSAID therapy. If you are using lithium alongside angiotensin II receptor antagonists or hydrochlorothiazide, your healthcare provider will monitor your serum lithium levels. Your healthcare provider will closely monitor your blood pressure, renal function, and electrolytes if you are on candesartan cilexetil and hydrochlorothiazide tablets along with other agents that affect the RAS. Do not take aliskiren with candesartan cilexetil and hydrochlorothiazide tablets if you have diabetes. Avoid using aliskiren with candesartan cilexetil and hydrochlorothiazide tablets if you have renal impairment (GFR <60 mL/min). Be cautious, as alcohol, barbiturates, or narcotics may increase the risk of orthostatic hypotension. You may need to adjust the dosage of your antidiabetic medication. Thiazide-induced low potassium or low magnesium levels may increase the risk of digoxin toxicity. You should decide whether to continue nursing or discontinue the drug, considering the importance of the medication to you. If neonates with a history of in utero exposure to candesartan cilexetil and hydrochlorothiazide tablets experience oliguria or hypotension, focus on supporting their blood pressure and renal perfusion. Pregnancy & Lactation You should decide whether to continue nursing or stop the medication, considering how important the medication is for you. Side Effects You may experience an upper respiratory tract infection (3.6% vs 3.0%). Back pain may occur (3.3% vs 2.4%). You might have influenza-like symptoms (2.5% vs 1.9%). Dizziness could be a side effect (2.9% vs 1.2%). Abnormal hepatic function is possible. Hepatitis may occur. You could experience neutropenia. Leukopenia is another potential side effect. Agranulocytosis may happen. Angioedema is a possibility. You might experience hyperkalemia. Hyponatremia could occur. Coughing may be a side effect. Pruritus might happen. You could develop a rash. Urticaria may occur. Rhabdomyolysis is a potential risk. Pancreatitis could happen. Jaundice (intrahepatic cholestatic jaundice) may occur. Sialadenitis is a possibility. Cramping might be experienced. Constipation could occur. Gastric irritation may happen. You might experience anorexia. Aplastic anemia is a potential side effect. Agranulocytosis may occur. Leukopenia could happen. Hemolytic anemia is a possibility. Thrombocytopenia may occur. Anaphylactic reactions are a serious risk. Necrotizing angiitis (vasculitis and cutaneous vasculitis) may occur. You could experience respiratory distress, including pneumonitis and pulmonary edema. Photosensitivity might happen. Urticaria may occur. Purpura could be a side effect. Muscle spasms might happen. There is an increased risk of non-melanoma skin cancer. Erythema multiforme, including Stevens-Johnson syndrome, may occur. Exfoliative dermatitis, including toxic epidermal necrolysis, is a possibility. Alopecia might happen. You may experience transient blurred vision. Xanthopsia could occur. Impotence may be a side effect. Symptomatic hypotension might happen. Oliguria could occur. Progressive azotemia is a potential risk. Acute renal failure may happen. Hyperkalemia could occur. Hypokalemia might be experienced. Hypomagnesemia is a possibility. Acute transient myopia may occur. Acute angle-closure glaucoma is a serious risk. Hypersensitivity reactions might happen. Warnings when pregnancy is detected, discontinue candesartan cilexetil and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus patients with symptomatic hypotension may require temporarily reducing the dose of candesartan cilexetil and hydrochlorothiazide tablets or volume repletion volume and/or salt depletion should be corrected before initiating therapy with candesartan cilexetil and hydrochlorothiazide tablets monitor renal function periodically in patients treated with candesartan cilexetil and hydrochlorothiazide tablets consider withholding or discontinuing therapy in patients who develop a clinically significant decrease in renal function on candesartan cilexetil and hydrochlorothiazide tablets drugs that inhibit the renin-angiotensin system can cause hyperkalemia hydrochlorothiazide can cause hypokalemia and hyponatremia monitor serum electrolytes periodically acute transient myopia and acute angle-closure glaucoma can occur with hydrochlorothiazide untreated acute angle-closure glaucoma can lead to permanent vision loss hypersensitivity reactions to hydrochlorothiazide may occur in patients with or without a history of allergy or bronchial asthma female patients of childbearing age should be told about the consequences of exposure to candesartan cilexetil and hydrochlorothiazide tablets during pregnancy tell patients receiving candesartan cilexetil and hydrochlorothiazide tablets that lightheadedness can occur, especially during the first days of therapy if syncope occurs, discontinue candesartan cilexetil and hydrochlorothiazide tablets until the physician has been consulted inadequate fluid intake, excessive perspiration, diarrhea, or vomiting can lead to an excessive fall in blood pressure tell patients receiving candesartan cilexetil and hydrochlorothiazide tablets not to use potassium supplements, salt substitutes containing potassium, or other drugs that may increase serum potassium levels without consulting the prescribing physician instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening monitor renal function periodically in patients receiving candesartan and NSAID therapy monitor serum lithium levels during concomitant use of lithium with angiotensin II receptor antagonists or hydrochlorothiazide closely monitor blood pressure, renal function and electrolytes in patients on candesartan cilexetil and hydrochlorothiazide tablets and other agents that affect the RAS do not co-administer aliskiren with candesartan cilexetil and hydrochlorothiazide tablets in patients with diabetes avoid use of aliskiren with candesartan cilexetil and hydrochlorothiazide tablets in patients with renal impairment (GFR <60 mL/min) potentiation of orthostatic hypotension may occur with alcohol, barbiturates, or narcotics dosage adjustment of the antidiabetic drug may be required thiazide-induced hypokalemia or hypomagnesemia may predispose to digoxin toxicity a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother if oliguria or hypotension occurs in neonates with a history of in utero exposure to candesartan cilexetil and hydrochlorothiazide tablets, direct attention toward support of blood pressure and renal perfusion Pregnancy & Lactation a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother Side Effects upper respiratory tract infection (3.6% vs 3.0%) back pain (3.3% vs 2.4%) influenza-like symptoms (2.5% vs 1.9%) dizziness (2.9% vs 1.2%) abnormal hepatic function hepatitis neutropenia leukopenia agranulocytosis angioedema hyperkalemia hyponatremia cough pruritus rash urticaria rhabdomyolysis pancreatitis jaundice (intrahepatic cholestatic jaundice) sialadenitis cramping constipation gastric irritation anorexia aplasticanemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity urticaria purpura muscle spasm increased risk of non-melanoma skin cancer erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia impotence symptomatic hypotension oliguria progressive azotemia acute renal failure hyperkalemia hypokalemia hypomagnesemia acute transient myopia acute angle-closure glaucoma hypersensitivity reactions
Candesartan Cilexetil and Hydrochlorothiazide Rx tablet Macleods Pharmaceuticals Limited	Popularity – score 0 out of 100 (least-viewed drug)	26 warnings	1 pregnancy and lactation warnings	48 side effects	Trend: fell 33% over the year; peaks in May, Aug, Sep.
Candesartan Cilexetil and Hydrochlorothiazide® · First marketed 2015 · Label last revised October 17, 2022View full label details → Warnings If you find out you are pregnant, please stop taking candesartan cilexetil and hydrochlorothiazide tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm your developing fetus. Using drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase risks for both the fetus and newborn. Your healthcare provider may perform serial ultrasound examinations to check the intra-amniotic environment. If oligohydramnios is detected, you should discontinue candesartan cilexetil and hydrochlorothiazide tablets, unless your healthcare provider determines it is lifesaving for you. Oligohydramnios may not be noticeable until after the fetus has experienced irreversible injury. Infants with a history of in utero exposure to candesartan cilexetil and hydrochlorothiazide tablets should be closely monitored for low blood pressure, reduced urine output, and high potassium levels. Candesartan cilexetil and hydrochlorothiazide can lead to symptomatic low blood pressure. Symptomatic low blood pressure is more likely to occur if you have been dehydrated or have restricted salt intake due to prolonged diuretic therapy, dietary changes, dialysis, diarrhea, or vomiting. If you experience symptomatic low blood pressure, you may need to temporarily reduce your dose of candesartan cilexetil and hydrochlorothiazide or receive fluids. Make sure to correct any volume or salt depletion before starting therapy with candesartan cilexetil and hydrochlorothiazide tablets. Your healthcare provider should monitor your renal function periodically while you are being treated with candesartan cilexetil and hydrochlorothiazide. If you experience a significant decrease in renal function while on candesartan cilexetil and hydrochlorothiazide, your healthcare provider may consider withholding or stopping the therapy. Medications that inhibit the renin-angiotensin system can lead to high potassium levels. Hydrochlorothiazide can cause low potassium and low sodium levels. It’s important to have your serum electrolytes monitored periodically. Hydrochlorothiazide may cause an unusual reaction that results in temporary nearsightedness and acute angle-closure glaucoma. If left untreated, acute angle-closure glaucoma can result in permanent vision loss. The main treatment is to stop taking hydrochlorothiazide as quickly as possible. Hypersensitivity reactions to hydrochlorothiazide can occur, even in those without a history of allergies or asthma, but are more common in those with such a history. If you are taking candesartan cilexetil and hydrochlorothiazide tablets, be aware that lightheadedness can happen, especially during the first few days of treatment, and you should report this to your prescribing physician. If you experience fainting, please stop taking candesartan cilexetil and hydrochlorothiazide tablets until you have consulted with your physician. Be aware that not drinking enough fluids, excessive sweating, diarrhea, or vomiting can lead to a significant drop in blood pressure, which may cause lightheadedness or fainting. If you are taking candesartan cilexetil and hydrochlorothiazide tablets, avoid using potassium supplements, salt substitutes containing potassium, or other medications that may raise your potassium levels without first consulting your prescribing physician. If you are taking hydrochlorothiazide, protect your skin from the sun and have regular skin cancer screenings. If oliguria or low blood pressure occurs in neonates with a history of in utero exposure to candesartan cilexetil and hydrochlorothiazide, focus on supporting blood pressure and kidney function. Pregnancy & Lactation You should decide whether to continue nursing or stop taking the medication, considering how important the medication is for you. Side Effects You may experience an upper respiratory tract infection (3.6% vs 3.0%). Back pain may occur (3.3% vs 2.4%). You might notice influenza-like symptoms (2.5% vs 1.9%). Dizziness can happen (2.9% vs 1.2%). Abnormal hepatic function is a possibility. Hepatitis may occur. You could experience neutropenia. Leukopenia might be a concern. Agranulocytosis is a potential side effect. Angioedema may develop. Hyperkalemia is something to watch for. You might experience hyponatremia. Coughing can occur. Pruritus may be experienced. A rash could develop. Urticaria might be a possibility. Rhabdomyolysis is a potential risk. Pancreatitis may occur. Jaundice (intrahepatic cholestatic jaundice) is a possibility. Sialadenitis might develop. Cramping can happen. You may experience constipation. Gastric irritation is a potential side effect. Anorexia might occur. Aplastic anemia is a risk. Hemolytic anemia may develop. Thrombocytopenia is a possibility. Anaphylactic reactions can occur. Necrotizing angiitis (vasculitis and cutaneous vasculitis) is a potential concern. You may experience respiratory distress, including pneumonitis and pulmonary edema. Photosensitivity might occur. Purpura can develop. Muscle spasms may happen. There is a risk of nonmelanoma skin cancer. Erythema multiforme, including Stevens-Johnson syndrome, is a potential side effect. Exfoliative dermatitis, including toxic epidermal necrolysis, may occur. Alopecia might develop. You may experience transient blurred vision. Xanthopsia is a possibility. Impotence can occur. Hypotension may happen. Acute renal failure is a potential risk. Hyperkalemia is something to watch for. Hypokalemia might occur. Hyponatremia is a possibility. Acute transient myopia may develop. Acute angle-closure glaucoma is a potential concern. Hypersensitivity reactions can occur. Warnings when pregnancy is detected, discontinue candesartan cilexetil and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death perform serial ultrasound examinations to assess the intra-amniotic environment if oligohydramnios is observed, discontinue candesartan cilexetil and hydrochlorothiazide tablets, unless it is considered lifesaving for the mother oligohydramnios may not appear until after the fetus has sustained irreversible injury closely observe infants with histories of in utero exposure to candesartan cilexetil and hydrochlorothiazide tablets for hypotension, oliguria, and hyperkalemia candesartan cilexetil and hydrochlorothiazide can cause symptomatic hypotension symptomatic hypotension is most likely to occur in patients who have been volume and/or salt depleted as a result of prolonged diuretic therapy, dietary salt restriction, dialysis, diarrhea, or vomiting patients with symptomatic hypotension may require temporarily reducing the dose of candesartan cilexetil and hydrochlorothiazide or volume repletion volume and/or salt depletion should be corrected before initiating therapy with candesartan cilexetil and hydrochlorothiazide tablets monitor renal function periodically in patients treated with candesartan cilexetil and hydrochlorothiazide consider withholding or discontinuing therapy in patients who develop a clinically significant decrease in renal function on candesartan cilexetil and hydrochlorothiazide drugs that inhibit the renin-angiotensin system can cause hyperkalemia hydrochlorothiazide can cause hypokalemia and hyponatremia monitor serum electrolytes periodically hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma untreated acute angle-closure glaucoma can lead to permanent vision loss the primary treatment is to discontinue hydrochlorothiazide as rapidly as possible hypersensitivity reactions to hydrochlorothiazide may occur in patients with or without a history of allergy or bronchial asthma, but are more likely in patients with such a history tell patients receiving candesartan cilexetil and hydrochlorothiazide tablet that lightheadedness can occur, especially during the first days of therapy, and that it should be reported to the prescribing physician tell patients that if syncope occurs, discontinue candesartan cilexetil and hydrochlorothiazide tablet until the physician has been consulted tell all patients that inadequate fluid intake, excessive perspiration, diarrhea, or vomiting can lead to an excessive fall in blood pressure, with the same consequences of lightheadedness and possible syncope tell patients receiving candesartan cilexetil and hydrochlorothiazide tablet not to use potassium supplements, salt substitutes containing potassium, or other drugs that may increase serum potassium levels without consulting the prescribing physician instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening if oliguria or hypotension occurs in neonates with a history of in utero exposure to candesartan cilexetil and hydrochlorothiazide, direct attention toward support of blood pressure and renal perfusion Pregnancy & Lactation a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother Side Effects upper respiratory tract infection (3.6% vs 3.0%) back pain (3.3% vs 2.4%) influenza-like symptoms (2.5% vs 1.9%) dizziness (2.9% vs 1.2%) abnormal hepatic function hepatitis neutropenia leukopenia agranulocytosis angioedema hyperkalemia hyponatremia cough pruritus rash urticaria rhabdomyolysis pancreatitis jaundice (intrahepatic cholestatic jaundice) sialadenitis cramping constipation gastric irritation anorexia aplastic anemia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity purpura muscle spasm nonmelanoma skin cancer erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia impotence hypotension acute renal failure hyperkalemia hypokalemia hyponatremia acute transient myopia acute angle-closure glaucoma hypersensitivity reactions
Candesartan Cilexetil and Hydrochlorothiazide Rx tablet ANI Pharmaceuticals, Inc.	Popularity – score 0 out of 100 (least-viewed drug)	27 warnings	1 pregnancy and lactation warnings	53 side effects	Trend: fell 33% over the year; peaks in May, Aug, Sep.
Candesartan Cilexetil and Hydrochlorothiazide® · First marketed 2018 · Label last revised December 22, 2025View full label details → Warnings If you find out you are pregnant, please stop taking candesartan cilexetil and hydrochlorothiazide tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus and may lead to serious complications. Using medications that act on the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase risks for both the fetus and newborn. If you find out you are pregnant, please stop taking candesartan cilexetil and hydrochlorothiazide tablets as soon as possible. In rare cases where there are no suitable alternatives to medications affecting the renin-angiotensin system, inform the mother about the potential risks to the fetus. Your healthcare provider may perform serial ultrasound examinations to evaluate the intra-amniotic environment. If oligohydramnios is detected, you should stop taking candesartan cilexetil and hydrochlorothiazide tablets, unless it is deemed lifesaving for you. Both you and your healthcare provider should be aware that oligohydramnios may not be evident until after the fetus has experienced irreversible harm. If you have a history of in utero exposure to candesartan cilexetil and hydrochlorothiazide tablets, your healthcare provider will closely monitor you for hypotension, oliguria, and hyperkalemia. Your healthcare provider should periodically check your renal function if you are being treated with candesartan cilexetil and hydrochlorothiazide tablets. If you experience a significant decrease in renal function while on candesartan cilexetil and hydrochlorothiazide tablets, your healthcare provider may consider adjusting or stopping your therapy. Candesartan cilexetil and hydrochlorothiazide tablets can lead to symptomatic hypotension. Symptomatic hypotension is more likely to occur if you have been volume or salt depleted due to prolonged diuretic therapy, dietary salt restriction, dialysis, diarrhea, or vomiting. If you experience symptomatic hypotension, you may need to temporarily reduce your dose of candesartan cilexetil and hydrochlorothiazide tablets or receive volume repletion. Make sure to correct any volume or salt depletion before starting therapy with candesartan cilexetil and hydrochlorothiazide tablets. If you have heart failure, be aware that candesartan cilexetil and hydrochlorothiazide tablets may cause excessive hypotension, which could lead to oliguria, azotemia, and, in rare cases, acute renal failure and death. Let your healthcare provider know if you experience lightheadedness while taking candesartan cilexetil and hydrochlorothiazide tablets, especially during the first few days of treatment. If you faint, please stop taking candesartan cilexetil and hydrochlorothiazide tablets until you have consulted with your healthcare provider. Be aware that inadequate fluid intake, excessive sweating, diarrhea, or vomiting can cause a significant drop in blood pressure, leading to lightheadedness and possible fainting. Do not take potassium supplements, potassium-containing salt substitutes, or other medications that may raise serum potassium levels without first consulting your healthcare provider. If you are taking hydrochlorothiazide, protect your skin from the sun and schedule regular skin cancer screenings. Hypersensitivity reactions to hydrochlorothiazide can occur in patients with or without a history of allergies or asthma, but they are more common in those with such a history. It is unclear whether candesartan is present in human milk, but it has been found in rat milk. Due to potential adverse effects on a nursing infant, you should decide whether to continue nursing or to stop the medication, considering the importance of the drug for your health. The safety and effectiveness of this medication in children have not been established. If you experience oliguria or hypotension, focus on supporting your blood pressure and renal perfusion. In some cases, exchange transfusions or dialysis may be necessary to reverse hypotension or to address impaired renal function. Pregnancy & Lactation You should decide whether to continue nursing or stop taking the medication, considering how important the medication is for you. Side Effects You may experience an upper respiratory tract infection (3.6% vs 3.0%). Back pain may occur (3.3% vs 2.4%). You might notice influenza-like symptoms (2.5% vs 1.9%). Dizziness could be a side effect (2.9% vs 1.2%). Abnormal hepatic function is possible. Hepatitis may occur. You could experience neutropenia. Leukopenia is a potential side effect. Agranulocytosis may happen. Angioedema is a possibility. Hyperkalemia could be a concern. Hyponatremia may occur. Coughing might be experienced. You may have pruritus. A rash could develop. Urticaria may occur. Rhabdomyolysis is a potential side effect. Pancreatitis could happen. Jaundice (intrahepatic cholestatic jaundice) may occur. Sialadenitis is a possibility. Cramping might be experienced. Constipation could occur. Gastric irritation may happen. You might experience anorexia. Aplastic anemia is a potential side effect. Agranulocytosis may occur. Leukopenia is a possibility. Hemolytic anemia could happen. Thrombocytopenia may occur. Anaphylactic reactions are a serious concern. Necrotizing angiitis (vasculitis and cutaneous vasculitis) may occur. You could experience respiratory distress, including pneumonitis and pulmonary edema. Photosensitivity might be a side effect. Urticaria may occur. Purpura could develop. Muscle spasms might be experienced. There is an increased risk of non-melanoma skin cancer. Erythema multiforme, including Stevens-Johnson syndrome, may occur. Exfoliative dermatitis, including toxic epidermal necrolysis, is a possibility. Alopecia may happen. You might experience transient blurred vision. Xanthopsia could occur. Impotence may be a side effect. Hypotension might happen. Oliguria could occur. Azotemia is a potential concern. Acute renal failure may happen. Hyperkalemia could be a concern. Hypokalemia may occur. Hyponatremia might happen. Acute transient myopia could occur. Acute angle-closure glaucoma is a possibility. Hypersensitivity reactions may happen. Warnings when pregnancy is detected, discontinue candesartan cilexetil and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue candesartan cilexetil and hydrochlorothiazide tablets as soon as possible in the unusual case that there is no appropriate alternative to therapy with drugs affecting the renin-angiotensin system for a particular patient, apprise the mother of the potential risk to the fetus perform serial ultrasound examinations to assess the intra-amniotic environment if oligohydramnios is observed, discontinue candesartan cilexetil and hydrochlorothiazide tablets, unless it is considered lifesaving for the mother patients and physicians should be aware, however, that oligohydramnios may not appear until after the fetus has sustained irreversible injury closely observe infants with histories of in utero exposure to candesartan cilexetil and hydrochlorothiazide tablets for hypotension, oliguria, and hyperkalemia monitor renal function periodically in patients treated with candesartan cilexetil and hydrochlorothiazide tablets consider withholding or discontinuing therapy in patients who develop a clinically significant decrease in renal function on candesartan cilexetil and hydrochlorothiazide tablets candesartan cilexetil and hydrochlorothiazide tablets can cause symptomatic hypotension symptomatic hypotension is most likely to occur in patients who have been volume and/or salt depleted as a result of prolonged diuretic therapy, dietary salt restriction, dialysis, diarrhea, or vomiting patients with symptomatic hypotension may require temporarily reducing the dose of candesartan cilexetil and hydrochlorothiazide tablets or volume repletion volume and/or salt depletion should be corrected before initiating therapy with candesartan cilexetil and hydrochlorothiazide tablets in patients with heart failure, candesartan cilexetil and hydrochlorothiazide tablets may cause excessive hypotension, which may lead to oliguria, azotemia, and (rarely) with acute renal failure and death tell patients receiving candesartan cilexetil and hydrochlorothiazide tablets that lightheadedness can occur, especially during the first days of therapy, and that it should be reported to the prescribing physician tell patients that if syncope occurs, discontinue candesartan cilexetil and hydrochlorothiazide tablets until the physician has been consulted tell all patients that inadequate fluid intake, excessive perspiration, diarrhea, or vomiting can lead to an excessive fall in blood pressure, with the same consequences of lightheadedness and possible syncope tell patients receiving candesartan cilexetil and hydrochlorothiazide tablets not to use potassium supplements, salt substitutes containing potassium, or other drugs that may increase serum potassium levels without consulting the prescribing physician instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening hypersensitivity reactions to hydrochlorothiazide may occur in patients with or without a history of allergy or bronchial asthma, but are more likely in patients with such a history it is not known whether candesartan is excreted in human milk, but candesartan has been shown to be present in rat milk because of the potential for adverse effects on the nursing infant, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother safety and effectiveness in pediatric patients have not been established if oliguria or hypotension occurs, direct attention toward support of blood pressure and renal perfusion exchange transfusions or dialysis may be required as a means of reversing hypotension and/or substituting for disordered renal function Pregnancy & Lactation a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother Side Effects upper respiratory tract infection (3.6% vs 3.0%) back pain (3.3% vs 2.4%) influenza-like symptoms (2.5% vs 1.9%) dizziness (2.9% vs 1.2%) abnormal hepatic function hepatitis neutropenia leukopenia agranulocytosis angioedema hyperkalemia hyponatremia cough pruritus rash urticaria rhabdomyolysis pancreatitis jaundice (intrahepatic cholestatic jaundice) sialadenitis cramping constipation gastric irritation anorexia aplastic anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity urticaria purpura muscle spasm increased risk of non-melanoma skin cancer erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia impotence hypotension oliguria azotemia acute renal failure hyperkalemia hypokalemia hyponatremia acute transient myopia acute angle-closure glaucoma hypersensitivity reactions
Candesartan Cilexetil and Hydrochlorothiazide Rx tablet Zydus Lifesciences Limited	Popularity – score 0 out of 100 (least-viewed drug)	0 warnings	0 pregnancy and lactation warnings	0 side effects	Trend: fell 33% over the year; peaks in May, Aug, Sep.
Candesartan Cilexetil and Hydrochlorothiazide® · First marketed 2018 · Label last revised November 11, 2024View full label details → Warnings No warnings reported. Pregnancy & Lactation No pregnancy & lactation warnings reported. Side Effects No side effects reported. Warnings No warnings reported. Pregnancy & Lactation No pregnancy & lactation warnings reported. Side Effects No side effects reported.
Candesartan Cilexetil and Hydrochlorothiazide Rx tablet Mylan Pharmaceuticals Inc.	Popularity – score 0 out of 100 (least-viewed drug)	17 warnings	1 pregnancy and lactation warnings	50 side effects	Trend: fell 33% over the year; peaks in May, Aug, Sep.
Candesartan Cilexetil and Hydrochlorothiazide® · First marketed 2012 · Label last revised August 15, 2020View full label details → Warnings If you find out you are pregnant, please stop taking candesartan cilexetil and hydrochlorothiazide tablets as soon as possible. Be aware that medications affecting the renin-angiotensin system can harm the developing fetus and may lead to serious complications. If you experience symptomatic hypotension, you may need to temporarily reduce your dose of candesartan cilexetil and hydrochlorothiazide tablets or receive volume repletion. Make sure to correct any volume and/or salt depletion before starting therapy with candesartan cilexetil and hydrochlorothiazide tablets. Your healthcare provider will periodically check your renal function while you are on candesartan cilexetil and hydrochlorothiazide tablets. If you notice a significant decrease in your renal function while taking candesartan cilexetil and hydrochlorothiazide tablets, your healthcare provider may consider withholding or stopping the therapy. Your healthcare provider will also monitor your serum electrolytes periodically. You should know that lightheadedness can occur, especially during the first few days of therapy with candesartan cilexetil and hydrochlorothiazide tablets, and it’s important to report this to your prescribing physician. If you experience syncope, please stop taking candesartan cilexetil and hydrochlorothiazide tablets and consult your physician before resuming. Remember that inadequate fluid intake, excessive sweating, diarrhea, or vomiting can lead to a significant drop in blood pressure, which may cause lightheadedness or syncope. Do not use potassium supplements, salt substitutes containing potassium, or other medications that may raise your serum potassium levels without first consulting your prescribing physician. If you are taking hydrochlorothiazide, be sure to protect your skin from the sun and have regular skin cancer screenings. Hypersensitivity reactions to hydrochlorothiazide can occur, even in those without a history of allergies or asthma, but they are more likely if you have such a history. If you are a female of childbearing age, it’s important to understand the potential consequences of using candesartan cilexetil and hydrochlorothiazide tablets during pregnancy. Please report any pregnancies to your physician as soon as possible. In rare cases where there are no suitable alternatives to medications affecting the renin-angiotensin system, it’s essential to inform the mother about the potential risks to the fetus. If you have an infant who was exposed to candesartan cilexetil and hydrochlorothiazide in utero, closely observe them for signs of hypotension, oliguria, and hyperkalemia. Pregnancy & Lactation You should decide whether to continue nursing or stop the medication, considering how important the medication is for you. Side Effects You may experience an upper respiratory tract infection (3.6% vs 3.0%). You might notice back pain (3.3% vs 2.4%). Influenza-like symptoms could occur (2.5% vs 1.9%). Dizziness may be a side effect (2.9% vs 1.2%). Be aware of abnormal hepatic function. Hepatitis is a potential concern. Neutropenia may occur. You could experience leukopenia. Agranulocytosis is a possible side effect. Angioedema may happen. Hyperkalemia is something to watch for. Hyponatremia could be a risk. Coughing may occur. You might experience pruritus. A rash could develop. Urticaria may be a side effect. Rhabdomyolysis is a potential concern. Pancreatitis may occur. Jaundice (intrahepatic cholestatic jaundice) is something to be aware of. Sialadenitis could happen. Cramping may be experienced. You might deal with constipation. Gastric irritation could occur. Anorexia is a potential side effect. Aplastic anemia may be a concern. Hemolytic anemia could occur. Thrombocytopenia is a possible side effect. Be aware of anaphylactic reactions. Necrotizing angiitis (vasculitis and cutaneous vasculitis) may occur. Respiratory distress, including pneumonitis and pulmonary edema, is a potential risk. Photosensitivity could be a concern. Purpura may develop. Muscle spasms might occur. There is an increased risk of non-melanoma skin cancer. Erythema multiforme, including Stevens-Johnson syndrome, is a potential side effect. Exfoliative dermatitis, including toxic epidermal necrolysis, may occur. Alopecia could happen. You might experience transient blurred vision. Xanthopsia is a potential side effect. Impotence may occur. Symptomatic hypotension could be a concern. Oliguria might happen. Progressive azotemia is a potential risk. Acute renal failure may occur. Hyperkalemia is something to watch for. Hypokalemia could be a concern. Hypomagnesemia may occur. Acute transient myopia is a potential side effect. Acute angle-closure glaucoma may be a risk. Hypersensitivity reactions could happen. Warnings when pregnancy is detected, discontinue candesartan cilexetil and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus patients with symptomatic hypotension may require temporarily reducing the dose of candesartan cilexetil and hydrochlorothiazide tablets or volume repletion volume and/or salt depletion should be corrected before initiating therapy with candesartan cilexetil and hydrochlorothiazide tablets monitor renal function periodically in patients treated with candesartan cilexetil and hydrochlorothiazide tablets consider withholding or discontinuing therapy in patients who develop a clinically significant decrease in renal function on candesartan cilexetil and hydrochlorothiazide tablets monitor serum electrolytes periodically tell patients receiving candesartan cilexetil and hydrochlorothiazide tablets that lightheadedness can occur, especially during the first days of therapy, and that it should be reported to the prescribing physician tell patients that if syncope occurs, discontinue candesartan cilexetil and hydrochlorothiazide tablets until the physician has been consulted tell all patients that inadequate fluid intake, excessive perspiration, diarrhea, or vomiting can lead to an excessive fall in blood pressure, with the same consequences of lightheadedness and possible syncope tell patients receiving candesartan cilexetil and hydrochlorothiazide tablets not to use potassium supplements, salt substitutes containing potassium, or other drugs that may increase serum potassium levels without consulting the prescribing physician instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening hypersensitivity reactions to hydrochlorothiazide may occur in patients with or without a history of allergy or bronchial asthma, but are more likely in patients with such a history female patients of childbearing age should be told about the consequences of exposure to candesartan cilexetil and hydrochlorothiazide tablets during pregnancy patients should be asked to report pregnancies to their physicians as soon as possible in the unusual case that there is no appropriate alternative to therapy with drugs affecting the renin-angiotensin system for a particular patient, apprise the mother of the potential risk to the fetus closely observe infants with histories of in utero exposure to candesartan cilexetil and hydrochlorothiazide for hypotension, oliguria, and hyperkalemia Pregnancy & Lactation a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother Side Effects upper respiratory tract infection (3.6% vs 3.0%) back pain (3.3% vs 2.4%) influenza-like symptoms (2.5% vs 1.9%) dizziness (2.9% vs 1.2%) abnormal hepatic function hepatitis neutropenia leukopenia agranulocytosis angioedema hyperkalemia hyponatremia cough pruritus rash urticaria rhabdomyolysis pancreatitis jaundice (intrahepatic cholestatic jaundice) sialadenitis cramping constipation gastric irritation anorexia aplastic anemia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity purpura muscle spasm increased risk of non-melanoma skin cancer erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia impotence symptomatic hypotension oliguria progressive azotemia acute renal failure hyperkalemia hypokalemia hypomagnesemia acute transient myopia acute angle-closure glaucoma hypersensitivity reactions
Captopril and Hydrochlorothiazide Rx tablet Rising Pharma Holdings, Inc.	Popularity – score 0 out of 100 (least-viewed drug)	32 warnings	5 pregnancy and lactation warnings	86 side effects	Trend: rose 150% over the year; peak in Sep; lows in Mar, Apr, Dec; bumpy overall.
Captopril and Hydrochlorothiazide® · First marketed 2023 · Label last revised February 21, 2023View full label details → Warnings If you are pregnant during the second and third trimesters, using ace inhibitors can harm your developing fetus and may even lead to death. As soon as you confirm your pregnancy, please discontinue captopril and hydrochlorothiazide as quickly as possible. If you are receiving ace inhibitors, be aware that you may experience a range of adverse reactions, some of which can be serious. Angioedema affecting your tongue, glottis, or larynx can occur and may be fatal. If angioedema affects your tongue, glottis, or larynx, it could lead to airway obstruction and may be fatal. There have been reports of intestinal angioedema in patients treated with ace inhibitors. Anaphylactoid reactions have been noted in patients who are dialyzed with high-flux membranes while also being treated with an ace inhibitor. Using captopril has been linked to neutropenia with myeloid hypoplasia. The risk of neutropenia depends on your clinical status. If you have some degree of renal failure, you may be at a higher risk for neutropenia. Patients with collagen vascular diseases and impaired renal function may also have an increased risk of neutropenia. If you are being treated with captopril, please report any signs of infection to your healthcare provider. Once neutropenia is confirmed, your physician should withdraw captopril and closely monitor your condition. About 0.7 percent of patients receiving captopril experienced total urinary proteins greater than 1 g per day. If you are salt or volume depleted, excessive hypotension may occur as a result of captopril use. Ace inhibitors can lead to fetal and neonatal complications and even death when given to pregnant women. When you confirm your pregnancy, please stop using ace inhibitors as soon as possible. If your infant has been exposed to ace inhibitors in utero, they should be closely monitored for hypotension, oliguria, and hyperkalemia. If you develop jaundice or significant elevations in hepatic enzymes while on ace inhibitors, please discontinue the medication. Use thiazides cautiously if you have severe renal disease. If you have impaired hepatic function or progressive liver disease, use thiazides with caution. Sensitivity reactions may occur, even if you do not have a history of allergy or bronchial asthma. There is a possibility that systemic lupus erythematosus may be exacerbated or activated. Please report any signs or symptoms of angioedema to your physician immediately. If you notice any signs of infection, which may indicate neutropenia, please report them promptly. Be cautious that excessive sweating and dehydration can lead to a significant drop in blood pressure. Do not use potassium-sparing diuretics, potassium supplements, or potassium-containing salt substitutes without consulting your physician. Please do not interrupt or stop your medication unless your physician instructs you to do so. If you have heart failure and are on captopril therapy, be careful about rapidly increasing your physical activity. If you are a female of childbearing age, please be aware of the risks associated with second- and third-trimester exposure to ace inhibitors. Report any pregnancies to your physician as soon as possible. Both captopril and hydrochlorothiazide are present in human milk, so you should decide whether to continue nursing or to stop the therapy. Pregnancy & Lactation Both captopril and hydrochlorothiazide can be found in human milk. You should discuss with your healthcare provider whether to continue nursing or therapy, considering how important captopril and hydrochlorothiazide are for you. If you are a female patient of childbearing age, it's important to understand the potential effects of using ACE inhibitors during the second and third trimesters of pregnancy. It seems that exposure to ACE inhibitors during the first trimester has not led to these consequences. Please inform your healthcare provider about any pregnancies as soon as possible. Side Effects You may experience proteinuria. You could have renal insufficiency. There is a possibility of renal failure. You might develop nephrotic syndrome. You may notice polyuria. Oliguria could occur. You might experience urinary frequency. Your healthcare provider should monitor for neutropenia/agranulocytosis. You may develop anemia. Thrombocytopenia could be a concern. Pancytopenia may occur. You might notice a rash, often accompanied by pruritus. Fever could be a symptom. You may experience arthralgia. Eosinophilia might be present. You could develop a maculopapular rash. An urticarial rash may occur. You might experience pruritus without a rash. Eosinophilia and/or positive ANA titers may be observed. You could have a reversible associated pemphigoid-like lesion. Photosensitivity might occur. You may experience flushing. Pallor could be a symptom. Hypotension may occur. Tachycardia might be present. You could experience chest pain. Palpitations may occur. Angina pectoris could be a concern. There is a risk of myocardial infarction. You might develop Raynaud’s syndrome. Congestive heart failure may occur. Dysgeusia could be a symptom. You may experience a cough. Gastric irritation might occur. You could have abdominal pain. Nausea may be present. Vomiting could occur. Diarrhea might be a concern. You may experience anorexia. Constipation could occur. Aphthous ulcers might develop. You could have a peptic ulcer. Dizziness may be a symptom. You might experience a headache. Malaise could occur. Fatigue may be present. Insomnia might be an issue. You may experience dry mouth. Dyspnea could occur. Alopecia might develop. Paresthesias may be present. You could experience anaphylactoid reactions. There is a risk of cardiac arrest. Cerebrovascular accident/insufficiency may occur. Rhythm disturbances could be a concern. You might experience orthostatic hypotension. Syncope may occur. Bullous pemphigus could develop. Erythema multiforme (including Stevens-Johnson syndrome) may occur. Exfoliative dermatitis might be a concern. You could develop pancreatitis. Glossitis may occur. Dyspepsia might be present. You may experience jaundice. Hepatitis (including rare cases of necrosis) could occur. Cholestasis may be a concern. You might experience symptomatic hyponatremia. Myalgia could occur. You may experience myasthenia. Ataxia might be present. You could experience confusion. Depression may occur. Nervousness might be a symptom. Somnolence could occur. You may experience bronchospasm. Eosinophilic pneumonitis might develop. Rhinitis may be present. You could experience blurred vision. Impotence might occur. Hyperglycemia may be a concern. Glycosuria could occur. Hyperuricemia might be present. You may experience muscle spasms. Weakness could occur. Restlessness may be a symptom. You might experience transient blurred vision. Warnings when used in pregnancy during the second and third trimesters, ace inhibitors can cause injury and even death to the developing fetus when pregnancy is detected, captopril and hydrochlorothiazide should be discontinued as soon as possible patients receiving ace inhibitors may be subject to a variety of adverse reactions, some of them serious angioedema involving the tongue, glottis or larynx may occur and be fatal if angioedema involves the tongue, glottis or larynx, airway obstruction may occur and be fatal intestinal angioedema has been reported in patients treated with ace inhibitors anaphylactoid reactions have been reported in patients dialyzed with high-flux membranes and treated concomitantly with an ace inhibitor neutropenia with myeloid hypoplasia has resulted from use of captopril the risk of neutropenia is dependent on the clinical status of the patient patients with some degree of renal failure may have a higher risk of neutropenia patients with collagen vascular diseases and impaired renal function may have a higher risk of neutropenia all patients treated with captopril should be told to report any signs of infection upon confirmation of neutropenia, the physician should withdraw captopril and closely follow the patient’s course total urinary proteins greater than 1 g per day were seen in about 0.7 percent of patients receiving captopril excessive hypotension is a possible consequence of captopril use in salt/volume depleted persons ace inhibitors can cause fetal and neonatal morbidity and death when administered to pregnant women when pregnancy is detected, ace inhibitors should be discontinued as soon as possible infants with histories of in utero exposure to ace inhibitors should be closely observed for hypotension, oliguria, and hyperkalemia patients receiving ace inhibitors who develop jaundice or marked elevations of hepatic enzymes should discontinue the ace inhibitor thiazides should be used with caution in severe renal disease thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma the possibility of exacerbation or activation of systemic lupus erythematosus has been reported patients should be advised to immediately report to their physician any signs or symptoms suggesting angioedema patients should be told to report promptly any indication of infection, which may be a sign of neutropenia patients should be cautioned that excessive perspiration and dehydration may lead to an excessive fall in blood pressure patients should be advised not to use potassium-sparing diuretics, potassium supplements or potassium-containing salt substitutes without consulting their physician patients should be warned against interruption or discontinuation of medication unless instructed by the physician heart failure patients on captopril therapy should be cautioned against rapid increases in physical activity female patients of childbearing age should be told about the consequences of second- and third-trimester exposure to ace inhibitors patients should be asked to report pregnancies to their physicians as soon as possible both captopril and hydrochlorothiazide are excreted in human milk, and a decision should be made whether to discontinue nursing or to discontinue therapy Pregnancy & Lactation both captopril and hydrochlorothiazide are excreted in human milk a decision should be made whether to discontinue nursing or to discontinue therapy taking into account the importance of captopril and hydrochlorothiazide to the mother female patients of childbearing age should be told about the consequences of second- and third-trimester exposure to ACE inhibitors these consequences do not appear to have resulted from intrauterine ACE-inhibitor exposure that has been limited to the first trimester these patients should be asked to report pregnancies to their physicians as soon as possible Side Effects proteinuria renal insufficiency renal failure nephrotic syndrome polyuria oliguria urinary frequency neutropenia/agranulocytosis anemia thrombocytopenia pancytopenia rash, often with pruritus fever arthralgia eosinophilia maculopapular rash urticarial rash pruritus, without rash eosinophilia and/or positive ANA titers reversible associated pemphigoid-like lesion photosensitivity flushing pallor hypotension tachycardia chest pain palpitations angina pectoris myocardial infarction Raynaud’s syndrome congestive heart failure dysgeusia cough gastric irritation abdominal pain nausea vomiting diarrhea anorexia constipation aphthous ulcers peptic ulcer dizziness headache malaise fatigue insomnia dry mouth dyspnea alopecia paresthesias anaphylactoid reactions cardiac arrest cerebrovascular accident/insufficiency rhythm disturbances orthostatic hypotension syncope bullous pemphigus erythema multiforme (including Stevens-Johnson syndrome) exfoliative dermatitis pancreatitis glossitis dyspepsia jaundice hepatitis (including rare cases of necrosis) cholestasis symptomatic hyponatremia myalgia myasthenia ataxia confusion depression nervousness somnolence bronchospasm eosinophilic pneumonitis rhinitis blurred vision impotence hyperglycemia glycosuria hyperuricemia muscle spasm weakness restlessness transient blurred vision
Chlorothiazide Sodium Rx injection, powder, lyophilized, for solution Sun Pharmaceutical Industries, Inc.	Popularity – score 0 out of 100 (least-viewed drug)	27 warnings	3 pregnancy and lactation warnings	66 side effects	Trend: fell 18% over the year; peaks in Apr, Oct; low from Jun to Jul; bumpy overall.
Chlorothiazide Sodium® · First marketed 2016 · Label last revised March 21, 2025View full label details → Warnings Intravenous use in infants and children is limited and generally not recommended. Use this medication with caution if you have severe renal disease. Thiazides may lead to azotemia if you have renal disease. If you have impaired renal function, be aware that cumulative effects of the drug may develop. Thiazides should be used cautiously if you have impaired hepatic function or progressive liver disease. Minor changes in fluid and electrolyte balance may trigger hepatic coma. Sensitivity reactions can occur in anyone, regardless of whether you have a history of allergy or bronchial asthma. There have been reports of exacerbation or activation of systemic lupus erythematosus. Hypokalemia may develop, especially with brisk diuresis, in the presence of severe cirrhosis or after prolonged therapy. Interference with adequate oral electrolyte intake can also contribute to hypokalemia. Hypokalemia may lead to cardiac arrhythmias and can increase the heart's sensitivity to the toxic effects of digitalis. Dilutional hyponatremia may occur in patients with edema during hot weather. Hyperuricemia may develop, or acute gout may be triggered in certain patients taking thiazides. If you are diabetic, dosage adjustments of insulin or oral hypoglycemic agents may be necessary. Hyperglycemia can occur with thiazide diuretics. Latent diabetes mellitus may become apparent during thiazide therapy. If you notice progressive renal impairment, consider discussing with your healthcare provider whether to withhold or discontinue diuretic therapy. Thiazides have been shown to increase urinary excretion of magnesium. Thiazides may decrease urinary calcium excretion. Marked hypercalcemia could indicate hidden hyperparathyroidism. Thiazides should be stopped before conducting tests for parathyroid function. Chlorothiazide should only be used during pregnancy if clearly necessary. Chlorothiazide may cause fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions. You should decide whether to continue nursing or to stop the drug, considering the importance of the medication to you. The safety and effectiveness of chlorothiazide sodium in pediatric patients have not been established. Be cautious in selecting doses for elderly patients. The risk of toxic reactions to this drug may be higher if you have impaired renal function. Pregnancy & Lactation You should use chlorothiazide during pregnancy only if it is clearly necessary. You and your healthcare provider should decide whether to stop nursing or to discontinue the drug, considering how important the medication is for you. Chlorothiazide may lead to fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Side Effects You may experience weakness. Hypotension, including orthostatic hypotension, may occur and can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. There is a risk of pancreatitis. You might develop jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea can occur. You may experience vomiting. Sialadenitis is a possible side effect. Cramping may happen. You could experience constipation. Gastric irritation is a potential issue. Nausea may occur. You might experience anorexia. Aplastic anemia is a serious risk. Agranulocytosis is a potential side effect. Leukopenia may occur. There is a risk of hemolytic anemia. Thrombocytopenia is a possible side effect. Anaphylactic reactions can happen. You may experience necrotizing angiitis, which includes vasculitis and cutaneous vasculitis. Respiratory distress, including pneumonitis and pulmonary edema, may occur. Photosensitivity is a potential side effect. You might develop a fever. Urticaria can occur. A rash may develop. Purpura is a possible side effect. Electrolyte imbalances may occur. You might experience hyperglycemia. Glycosuria can happen. Hyperuricemia is a potential side effect. Muscle spasms may occur. You might experience vertigo. Paresthesias can happen. Dizziness may occur. You might experience headaches. Restlessness is a possible side effect. Erythema multiforme, including Stevens-Johnson syndrome, may occur. Exfoliative dermatitis, including toxic epidermal necrolysis, is a potential risk. Alopecia may happen. You might experience transient blurred vision. Xanthopsia is a possible side effect. There is a risk of renal failure. Renal dysfunction may occur. Interstitial nephritis is a potential side effect. Hematuria may occur following intravenous use. Impotence is a possible side effect. You might experience hyponatremia. Hypochloremic alkalosis can happen. Hypokalemia is a potential risk. Dryness of the mouth may occur. You might feel increased thirst. Lethargy is a possible side effect. Drowsiness may occur. You might experience confusion. Seizures are a serious risk. Muscle pains or cramps may happen. Muscular fatigue is a potential side effect. Tachycardia may occur. Gastrointestinal disturbances, such as nausea and vomiting, can happen. Hyperuricemia is a potential side effect. Acute gout may occur. Hyperglycemia may happen with thiazide diuretics. Latent diabetes mellitus may become apparent during thiazide therapy. Hypomagnesemia is a possible side effect. You might experience intermittent and slight elevation of serum calcium. Marked hypercalcemia may indicate hidden hyperparathyroidism. Increases in cholesterol and triglyceride levels may occur. Warnings intravenous use in infants and children has been limited and is not generally recommended use with caution in severe renal disease thiazides may precipitate azotemia in patients with renal disease cumulative effects of the drug may develop in patients with impaired renal function thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease minor alterations of fluid and electrolyte balance may precipitate hepatic coma sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma the possibility of exacerbation or activation of systemic lupus erythematosus has been reported hypokalemia may develop especially with brisk diuresis, when severe cirrhosis is present or after prolonged therapy interference with adequate oral electrolyte intake will also contribute to hypokalemia hypokalemia may cause cardiac arrhythmias and may also sensitize or exaggerate the response of the heart to the toxic effects of digitalis dilutional hyponatremia may occur in edematous patients in hot weather hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazides in diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required hyperglycemia may occur with thiazide diuretics latent diabetes mellitus may become manifest during thiazide therapy if progressive renal impairment becomes evident, consider withholding or discontinuing diuretic therapy thiazides have been shown to increase the urinary excretion of magnesium thiazides may decrease urinary calcium excretion marked hypercalcemia may be evidence of hidden hyperparathyroidism thiazides should be discontinued before carrying out tests for parathyroid function chlorothiazide should be used during pregnancy only if clearly needed chlorothiazide may cause fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother safety and effectiveness of chlorothiazide sodium in pediatric patients have not been established care should be taken in dose selection for elderly patients the risk of toxic reactions to this drug may be greater in patients with impaired renal function Pregnancy & Lactation chlorothiazide should be used during pregnancy only if clearly needed a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother chlorothiazide may cause fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions which have occurred in the adult Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastric anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesias dizziness headache restlessness erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia renal failure renal dysfunction interstitial nephritis hematuria (following intravenous use) impotence hyponatremia hypochloremic alkalosis hypokalemia dryness of mouth thirst lethargy drowsiness confusion seizures muscle pains or cramps muscular fatigue tachycardia gastrointestinal disturbances such as nausea and vomiting hyperuricemia acute gout hyperglycemia may occur with thiazide diuretics latent diabetes mellitus may become manifest during thiazide therapy hypomagnesemia intermittent and slight elevation of serum calcium marked hypercalcemia may be evidence of hidden hyperparathyroidism increases in cholesterol and triglyceride levels
Chlorothiazide Sodium Rx injection, powder, lyophilized, for solution Sagent Pharmaceuticals	Popularity – score 0 out of 100 (least-viewed drug)	34 warnings	3 pregnancy and lactation warnings	45 side effects	Trend: fell 18% over the year; peaks in Apr, Oct; low from Jun to Jul; bumpy overall.
Chlorothiazide Sodium® · First marketed 2015 · Label last revised August 15, 2024View full label details → Warnings If you are an infant or child, intravenous use has been limited and is generally not recommended. Use this medication with caution if you have severe renal disease. If you have renal disease, thiazides may lead to azotemia. Cumulative effects of the drug may develop if you have impaired renal function. Thiazides should be used cautiously if you have impaired hepatic function or progressive liver disease. Minor changes in fluid and electrolyte balance may lead to hepatic coma. Sensitivity reactions may occur in you, whether or not you have a history of allergy or bronchial asthma. There have been reports of exacerbation or activation of systemic lupus erythematosus. You generally should not take lithium with diuretics. If you are receiving diuretic therapy, your healthcare provider should monitor you for signs of fluid or electrolyte imbalance. Warning signs of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting. Hypokalemia may develop, especially with brisk diuresis, in the presence of severe cirrhosis, or after prolonged therapy. Not getting enough oral electrolytes can also contribute to hypokalemia. Hypokalemia may lead to cardiac arrhythmias and can increase the heart's sensitivity to the toxic effects of digitalis. You can avoid or treat hypokalemia by using potassium-sparing diuretics or potassium supplements, such as foods rich in potassium. Dilutional hyponatremia may occur in you if you are edematous and in hot weather. The appropriate therapy for this condition is water restriction, rather than administering salt, except in rare cases when hyponatremia is life-threatening. If you are experiencing actual salt depletion, appropriate replacement is the therapy of choice. Hyperuricemia may occur, or acute gout may be triggered in certain patients receiving thiazides. If you are diabetic, dosage adjustments of insulin or oral hypoglycemic agents may be necessary. Hyperglycemia may occur with thiazide diuretics. Latent diabetes mellitus may become apparent during thiazide therapy. If you notice progressive renal impairment, consider discussing with your healthcare provider the possibility of withholding or discontinuing diuretic therapy. Thiazides have been shown to increase urinary excretion of magnesium, which may result in hypomagnesemia. Thiazides may decrease urinary calcium excretion. Thiazides may cause intermittent and slight elevation of serum calcium in the absence of known disorders of calcium metabolism. Marked hypercalcemia may indicate hidden hyperparathyroidism. You should discontinue thiazides before undergoing tests for parathyroid function. Chlorothiazide should only be used during pregnancy if clearly needed. Chlorothiazide may cause fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults. Due to the potential for serious adverse reactions in nursing infants from chlorothiazide sodium for injection, you should decide whether to discontinue nursing or the medication. The safety and effectiveness of chlorothiazide sodium for injection in pediatric patients have not been established. If you are an elderly patient, care should be taken in dose selection, usually starting at the low end of the dosing range. The risk of toxic reactions to this drug may be greater if you have impaired renal function. Pregnancy & Lactation You should use chlorothiazide during pregnancy only if it is clearly needed. Chlorothiazide may cause fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. You and your healthcare provider should decide whether to discontinue nursing or to stop the medication, considering how important the drug is for you. Side Effects You may experience weakness. You might have hypotension, including orthostatic hypotension, which can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. Pancreatitis is a possible side effect. You could develop jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea may occur. You might experience vomiting. Sialadenitis is another potential side effect. Cramping can happen. You may experience constipation. Gastric irritation is possible. Nausea may occur. You might have anorexia. Aplastic anemia is a serious side effect to be aware of. Agranulocytosis could occur. You may experience leukopenia. Hemolytic anemia is a potential risk. Thrombocytopenia may happen. Be aware of the possibility of anaphylactic reactions. Necrotizing angiitis, including vasculitis and cutaneous vasculitis, is a potential side effect. You might experience respiratory distress, which can include pneumonitis and pulmonary edema. Photosensitivity is a possible reaction. Fever may occur. You might experience urticaria. A rash could develop. Purpura is another potential side effect. Electrolyte imbalance may happen. You might experience hyperglycemia. Glycosuria is a possible side effect. Hyperuricemia may occur. Muscle spasms can happen. You might experience vertigo. Paresthesias may occur. Dizziness is a potential side effect. You might have headaches. Restlessness can happen. Erythema multiforme, including Stevens-Johnson syndrome, is a serious risk. Exfoliative dermatitis, including toxic epidermal necrolysis, may occur. Alopecia is a possible side effect. You might experience transient blurred vision. Xanthopsia could occur. Renal failure is a serious concern. You may experience renal dysfunction. Interstitial nephritis is a potential side effect. Hematuria may occur, especially following intravenous use. Impotence is another possible side effect. Warnings intravenous use in infants and children has been limited and is not generally recommended use with caution in severe renal disease in patients with renal disease, thiazides may precipitate azotemia cumulative effects of the drug may develop in patients with impaired renal function thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease minor alterations of fluid and electrolyte balance may precipitate hepatic coma sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma the possibility of exacerbation or activation of systemic lupus erythematosus has been reported lithium generally should not be given with diuretics all patients receiving diuretic therapy should be observed for evidence of fluid or electrolyte imbalance warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting hypokalemia may develop especially with brisk diuresis, when severe cirrhosis is present or after prolonged therapy interference with adequate oral electrolyte intake will also contribute to hypokalemia hypokalemia may cause cardiac arrhythmias and may also sensitize or exaggerate the response of the heart to the toxic effects of digitalis hypokalemia may be avoided or treated by use of potassium-sparing diuretics or potassium supplements such as foods with a high potassium content dilutional hyponatremia may occur in edematous patients in hot weather appropriate therapy is water restriction, rather than administration of salt, except in rare instances when the hyponatremia is life-threatening in actual salt depletion, appropriate replacement is the therapy of choice hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazides in diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required hyperglycemia may occur with thiazide diuretics latent diabetes mellitus may become manifest during thiazide therapy if progressive renal impairment becomes evident, consider withholding or discontinuing diuretic therapy thiazides have been shown to increase the urinary excretion of magnesium; this may result in hypomagnesemia thiazides may decrease urinary calcium excretion thiazides may cause intermittent and slight elevation of serum calcium in the absence of known disorders of calcium metabolism marked hypercalcemia may be evidence of hidden hyperparathyroidism thiazides should be discontinued before carrying out tests for parathyroid function chlorothiazide should be used during pregnancy only if clearly needed chlorothiazide may cause fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions which have occurred in the adult because of the potential for serious adverse reactions in nursing infants from chlorothiazide sodium for injection, a decision should be made whether to discontinue nursing or to discontinue the drug safety and effectiveness of chlorothiazide sodium for injection in pediatric patients have not been established care should be taken in dose selection for elderly patients, usually starting at the low end of the dosing range the risk of toxic reactions to this drug may be greater in patients with impaired renal function Pregnancy & Lactation chlorothiazide should be used during pregnancy only if clearly needed chlorothiazide may cause fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions which have occurred in the adult a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastric anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesias dizziness headache restlessness erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia renal failure renal dysfunction interstitial nephritis hematuria (following intravenous use) impotence
Chlorothiazide Sodium Rx injection, powder, lyophilized, for solution Sagent Pharmaceuticals	Popularity – score 0 out of 100 (least-viewed drug)	33 warnings	3 pregnancy and lactation warnings	45 side effects	Trend: fell 18% over the year; peaks in Apr, Oct; low from Jun to Jul; bumpy overall.
Chlorothiazide Sodium® · First marketed 2019 · Label last revised January 21, 2021View full label details → Warnings If you are an infant or child, intravenous use has been limited and is generally not recommended. Use this medication with caution if you have severe renal disease. If you have renal disease, thiazides may lead to azotemia. Cumulative effects of the drug may develop if you have impaired renal function. Use thiazides with caution if you have impaired hepatic function or progressive liver disease. Minor changes in fluid and electrolyte balance may lead to hepatic coma. Sensitivity reactions may occur in you, whether or not you have a history of allergy or bronchial asthma. There have been reports of exacerbation or activation of systemic lupus erythematosus. You generally should not take lithium with diuretics. If you are receiving diuretic therapy, your healthcare provider should monitor you for signs of fluid or electrolyte imbalance. Warning signs of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting. Hypokalemia may develop, especially with brisk diuresis, in the presence of severe cirrhosis, or after prolonged therapy. Not getting enough oral electrolytes can also contribute to hypokalemia. Hypokalemia may lead to cardiac arrhythmias and can increase the heart's sensitivity to the toxic effects of digitalis. You can avoid or treat hypokalemia by using potassium-sparing diuretics or potassium supplements, such as foods high in potassium. Dilutional hyponatremia may occur in patients with edema during hot weather. The appropriate therapy for this condition is water restriction, rather than administering salt, except in rare cases when hyponatremia is life-threatening. In cases of actual salt depletion, appropriate replacement is the best therapy. Hyperuricemia may occur, or acute gout may be triggered in certain patients taking thiazides. If you are diabetic, dosage adjustments of insulin or oral hypoglycemic agents may be necessary. Hyperglycemia may occur with thiazide diuretics. Latent diabetes mellitus may become apparent during thiazide therapy. If you notice progressive renal impairment, consider discussing with your healthcare provider the possibility of withholding or discontinuing diuretic therapy. Thiazides have been shown to increase urinary excretion of magnesium, which may result in hypomagnesemia. Thiazides may decrease urinary calcium excretion. Thiazides may cause slight and intermittent elevation of serum calcium in the absence of known calcium metabolism disorders. Marked hypercalcemia may indicate hidden hyperparathyroidism. You should discontinue thiazides before undergoing tests for parathyroid function. Chlorothiazide should only be used during pregnancy if clearly needed. Chlorothiazide may cause fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults. The safety and effectiveness of chlorothiazide sodium for injection in children have not been established. The risk of toxic reactions to this drug may be higher if you have impaired renal function. Care should be taken in selecting the dose for elderly patients. Pregnancy & Lactation You should use chlorothiazide during pregnancy only if it is clearly needed. Chlorothiazide may cause fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. You will need to decide whether to continue nursing or to stop the medication, considering how important the drug is for your health. Side Effects You may experience weakness. You might have hypotension, including orthostatic hypotension, which can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. There is a possibility of developing pancreatitis. You could experience jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea may occur. You might feel nauseous and experience vomiting. Sialadenitis is a potential side effect. Cramping may happen. You could experience constipation. Gastric irritation is possible. Nausea may be a concern. You might experience anorexia. Aplastic anemia is a serious potential side effect. Agranulocytosis could occur. You may experience leukopenia. There is a risk of hemolytic anemia. Thrombocytopenia is a possible side effect. Anaphylactic reactions may occur. You could develop necrotizing angiitis, which includes vasculitis and cutaneous vasculitis. Respiratory distress, including pneumonitis and pulmonary edema, may happen. You might experience photosensitivity. Fever could be a side effect. Urticaria may occur. You might develop a rash. Purpura is a potential side effect. Electrolyte imbalance may happen. You could experience hyperglycemia. Glycosuria is a possibility. Hyperuricemia may occur. Muscle spasms could happen. You might feel vertigo. Paresthesias may occur. Dizziness is a potential side effect. You might experience headaches. Restlessness could be a concern. Erythema multiforme, including Stevens-Johnson syndrome, is a serious potential side effect. Exfoliative dermatitis, including toxic epidermal necrolysis, may occur. Alopecia is a possibility. You might experience transient blurred vision. Xanthopsia could happen. There is a risk of renal failure. Renal dysfunction may occur. Interstitial nephritis is a potential side effect. Hematuria may occur following intravenous use. You might experience impotence. Warnings intravenous use in infants and children has been limited and is not generally recommended use with caution in severe renal disease in patients with renal disease, thiazides may precipitate azotemia cumulative effects of the drug may develop in patients with impaired renal function thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease minor alterations of fluid and electrolyte balance may precipitate hepatic coma sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma the possibility of exacerbation or activation of systemic lupus erythematosus has been reported lithium generally should not be given with diuretics all patients receiving diuretic therapy should be observed for evidence of fluid or electrolyte imbalance warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting hypokalemia may develop especially with brisk diuresis, when severe cirrhosis is present or after prolonged therapy interference with adequate oral electrolyte intake will also contribute to hypokalemia hypokalemia may cause cardiac arrhythmias and may also sensitize or exaggerate the response of the heart to the toxic effects of digitalis hypokalemia may be avoided or treated by use of potassium-sparing diuretics or potassium supplements such as foods with a high potassium content dilutional hyponatremia may occur in edematous patients in hot weather appropriate therapy is water restriction, rather than administration of salt, except in rare instances when the hyponatremia is life-threatening in actual salt depletion, appropriate replacement is the therapy of choice hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazides in diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required hyperglycemia may occur with thiazide diuretics latent diabetes mellitus may become manifest during thiazide therapy if progressive renal impairment becomes evident, consider withholding or discontinuing diuretic therapy thiazides have been shown to increase the urinary excretion of magnesium; this may result in hypomagnesemia thiazides may decrease urinary calcium excretion thiazides may cause intermittent and slight elevation of serum calcium in the absence of known disorders of calcium metabolism marked hypercalcemia may be evidence of hidden hyperparathyroidism thiazides should be discontinued before carrying out tests for parathyroid function chlorothiazide should be used during pregnancy only if clearly needed chlorothiazide may cause fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions which have occurred in the adult safety and effectiveness of chlorothiazide sodium for injection in pediatric patients have not been established the risk of toxic reactions to this drug may be greater in patients with impaired renal function care should be taken in dose selection for elderly patients Pregnancy & Lactation chlorothiazide should be used during pregnancy only if clearly needed chlorothiazide may cause fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions which have occurred in the adult a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastric anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesias dizziness headache restlessness erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia renal failure renal dysfunction interstitial nephritis hematuria (following intravenous use) impotence
Chlorothiazide Sodium Rx injection, powder, lyophilized, for solution American Regent, Inc.	Popularity – score 0 out of 100 (least-viewed drug)	27 warnings	4 pregnancy and lactation warnings	60 side effects	Trend: fell 18% over the year; peaks in Apr, Oct; low from Jun to Jul; bumpy overall.
Chlorothiazide Sodium® · First marketed 2015 · Label last revised June 5, 2020View full label details → Warnings If you are an infant or child, intravenous use has been limited and is generally not recommended. Use this medication with caution if you have severe renal disease. If you have renal disease, thiazides may lead to azotemia. Cumulative effects of the drug may develop if you have impaired renal function. If you have impaired hepatic function or progressive liver disease, thiazides should be used with caution. Minor changes in fluid and electrolyte balance may lead to hepatic coma. Sensitivity reactions may occur in you, whether or not you have a history of allergy or bronchial asthma. There have been reports of exacerbation or activation of systemic lupus erythematosus. Hypokalemia may develop, especially with brisk diuresis, in the presence of severe cirrhosis or after prolonged therapy. Interference with adequate oral electrolyte intake can also contribute to hypokalemia. Hypokalemia may cause cardiac arrhythmias and can sensitize or exaggerate the heart's response to the toxic effects of digitalis. Dilutional hyponatremia may occur in you if you are edematous and in hot weather. Hyperuricemia may occur, or acute gout may be triggered in certain patients receiving thiazides. If you are diabetic, dosage adjustments of insulin or oral hypoglycemic agents may be necessary. Hyperglycemia may occur while taking thiazide diuretics. Latent diabetes mellitus may become apparent during thiazide therapy. If you notice progressive renal impairment, consider discussing with your healthcare provider the possibility of withholding or discontinuing diuretic therapy. Thiazides have been shown to increase urinary excretion of magnesium, which may result in hypomagnesemia. Thiazides may decrease urinary calcium excretion. Thiazides may cause intermittent and slight elevation of serum calcium in the absence of known disorders of calcium metabolism. Marked hypercalcemia may indicate hidden hyperparathyroidism. Thiazides should be discontinued before you undergo tests for parathyroid function. Chlorothiazide sodium for injection should only be used during pregnancy if clearly needed. Chlorothiazide may cause fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults. Due to the potential for serious adverse reactions in nursing infants from chlorothiazide sodium for injection, you should decide whether to continue nursing or to discontinue the drug. The safety and effectiveness of chlorothiazide sodium for injection in pediatric patients have not been established. The risk of toxic reactions to this drug may be greater if you have impaired renal function. Pregnancy & Lactation You should decide whether to stop nursing or to discontinue the drug, considering how important the medication is for you. Chlorothiazide sodium for injection should only be used during pregnancy if it is clearly necessary. It is not known if chlorothiazide can harm the fetus when given to a pregnant woman. Chlorothiazide may lead to fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions. Side Effects You may experience weakness. You might have hypotension, including orthostatic hypotension, which can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. There is a possibility of developing pancreatitis. You could experience jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea may occur. You might feel nauseous and experience vomiting. Sialadenitis is a potential side effect. Cramping may happen. You could experience constipation. Gastric irritation is possible. Nausea may be a concern. You might experience a loss of appetite (anorexia). Aplastic anemia is a serious potential side effect. Agranulocytosis could occur. You may experience leukopenia. There is a risk of hemolytic anemia. Thrombocytopenia is a possible side effect. Anaphylactic reactions may occur. You could develop necrotizing angiitis, which includes vasculitis and cutaneous vasculitis. Respiratory distress, including pneumonitis and pulmonary edema, may happen. Photosensitivity is a potential side effect. You might experience fever. Urticaria could occur. A rash may develop. Purpura is a possible side effect. You may experience an electrolyte imbalance. Hyperglycemia could occur. Glycosuria is a potential concern. You might experience hyperuricemia. Muscle spasms may happen. You could feel vertigo. Paresthesias may occur. Dizziness is a possible side effect. You might experience headaches. Restlessness could be a concern. Erythema multiforme, including Stevens-Johnson syndrome, is a serious potential side effect. Exfoliative dermatitis, including toxic epidermal necrolysis, may occur. Alopecia is a possible side effect. You might experience transient blurred vision. Xanthopsia could occur. There is a risk of renal failure. Renal dysfunction may happen. Interstitial nephritis is a potential concern. Hematuria may occur following intravenous use. You might experience impotence. Hyponatremia is a possible side effect. Hypochloremic alkalosis could occur. Hypokalemia is a potential concern. You may experience dryness of the mouth. Thirst could be a side effect. Lethargy may occur. Drowsiness is a possible side effect. You might experience confusion. Seizures are a serious potential side effect. Muscle pains or cramps may happen. You could experience muscular fatigue. Tachycardia is a possible side effect. Gastrointestinal disturbances, such as nausea and vomiting, may occur. Hyperuricemia could happen. Hyperglycemia is a potential concern. Warnings intravenous use in infants and children has been limited and is not generally recommended use with caution in severe renal disease in patients with renal disease, thiazides may precipitate azotemia cumulative effects of the drug may develop in patients with impaired renal function thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease minor alterations of fluid and electrolyte balance may precipitate hepatic coma sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma the possibility of exacerbation or activation of systemic lupus erythematosus has been reported hypokalemia may develop especially with brisk diuresis, when severe cirrhosis is present or after prolonged therapy interference with adequate oral electrolyte intake will also contribute to hypokalemia hypokalemia may cause cardiac arrhythmias and may also sensitize or exaggerate the response of the heart to the toxic effects of digitalis dilutional hyponatremia may occur in edematous patients in hot weather hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazides in diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required hyperglycemia may occur with thiazide diuretics latent diabetes mellitus may become manifest during thiazide therapy if progressive renal impairment becomes evident, consider withholding or discontinuing diuretic therapy thiazides have been shown to increase the urinary excretion of magnesium; this may result in hypomagnesemia thiazides may decrease urinary calcium excretion thiazides may cause intermittent and slight elevation of serum calcium in the absence of known disorders of calcium metabolism marked hypercalcemia may be evidence of hidden hyperparathyroidism thiazides should be discontinued before carrying out tests for parathyroid function chlorothiazide sodium for injection should be used during pregnancy only if clearly needed chlorothiazide may cause fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions which have occurred in the adult because of the potential for serious adverse reactions in nursing infants from chlorothiazide sodium for injection, a decision should be made whether to discontinue nursing or to discontinue the drug safety and effectiveness of chlorothiazide sodium for injection in pediatric patients have not been established the risk of toxic reactions to this drug may be greater in patients with impaired renal function Pregnancy & Lactation a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother chlorothiazide sodium for injection should be used during pregnancy only if clearly needed it is not known whether chlorothiazide can cause fetal harm when administered to a pregnant woman chlorothiazide may cause fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastic anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesias dizziness headache restlessness erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia renal failure renal dysfunction interstitial nephritis hematuria (following intravenous use) impotence hyponatremia hypochloremic alkalosis hypokalemia dryness of mouth thirst lethargy drowsiness confusion seizures muscle pains or cramps muscular fatigue tachycardia gastrointestinal disturbances such as nausea and vomiting hyperuricemia hyperglycemia
Chlorothiazide Sodium Rx injection, powder, lyophilized, for solution Gland Pharma Limited	Popularity – score 0 out of 100 (least-viewed drug)	33 warnings	3 pregnancy and lactation warnings	45 side effects	Trend: fell 18% over the year; peaks in Apr, Oct; low from Jun to Jul; bumpy overall.
Chlorothiazide Sodium® · First marketed 2024 · Label last revised October 7, 2024View full label details → Warnings If you are an infant or child, intravenous use has been limited and is generally not recommended. Use this medication with caution if you have severe renal disease. If you have renal disease, thiazides may lead to azotemia. Cumulative effects of the drug may develop if you have impaired renal function. If you have impaired hepatic function or progressive liver disease, thiazides should be used with caution. Minor changes in fluid and electrolyte balance may lead to hepatic coma. Sensitivity reactions may occur in you, whether or not you have a history of allergy or bronchial asthma. There have been reports of exacerbation or activation of systemic lupus erythematosus. Lithium generally should not be taken with diuretics. If you are receiving diuretic therapy, your healthcare provider should monitor you for signs of fluid or electrolyte imbalance. Warning signs of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, low blood pressure, reduced urine output, rapid heartbeat, and gastrointestinal issues like nausea and vomiting. Hypokalemia may develop, especially with brisk diuresis, in cases of severe cirrhosis, or after prolonged therapy. Not getting enough oral electrolytes can also contribute to hypokalemia. Hypokalemia may lead to cardiac arrhythmias and can increase the heart's sensitivity to the toxic effects of digitalis. You can avoid or treat hypokalemia by using potassium-sparing diuretics or potassium supplements. Dilutional hyponatremia may occur in patients with edema during hot weather. The appropriate treatment is to restrict water intake, rather than giving salt, except in rare cases where hyponatremia is life-threatening. In cases of actual salt depletion, appropriate replacement is the best therapy. Hyperuricemia may occur, or acute gout may be triggered in some patients taking thiazides. If you are diabetic, dosage adjustments of insulin or oral hypoglycemic agents may be necessary. Hyperglycemia may occur with thiazide diuretics. Latent diabetes mellitus may become apparent during thiazide therapy. If you notice progressive renal impairment, consider discussing with your healthcare provider the possibility of withholding or discontinuing diuretic therapy. Thiazides have been shown to increase urinary excretion of magnesium, which may lead to hypo-magnesemia. Thiazides may decrease the excretion of calcium in urine. Marked hypercalcemia may indicate hidden hyperparathyroidism. Thiazides should be stopped before conducting tests for parathyroid function. Chlorothiazide should only be used during pregnancy if it is clearly necessary. Chlorothiazide may cause fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults. You should decide whether to stop nursing or to discontinue the drug, considering the importance of the medication to you. The safety and effectiveness of chlorothiazide sodium for injection in children have not been established. Care should be taken in selecting the dose for elderly patients. The risk of toxic reactions to this drug may be higher if you have impaired renal function. Pregnancy & Lactation You should use chlorothiazide during pregnancy only if it is clearly needed. Chlorothiazide may cause fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. You and your healthcare provider should decide whether to discontinue nursing or to stop the medication, considering how important the drug is for you. Side Effects You may experience weakness. Hypotension, including orthostatic hypotension, may occur and can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. There is a risk of pancreatitis. You might develop jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea can occur. You may experience vomiting. Sialadenitis is a possible side effect. Cramping may happen. Constipation can occur. Gastric irritation is a potential side effect. Nausea may be experienced. You might have a decreased appetite (anorexia). Aplastic anemia is a serious risk. Agranulocytosis may occur. Leukopenia is a possible side effect. You could experience hemolytic anemia. Thrombocytopenia may occur. Be aware of the risk of anaphylactic reactions. Necrotizing angiitis, including vasculitis and cutaneous vasculitis, may occur. Respiratory distress, including pneumonitis and pulmonary edema, is a potential concern. You may experience photosensitivity. Fever can occur. Urticaria may develop. A rash is a possible side effect. Purpura may occur. You should be aware of the risk of electrolyte imbalance (see PRECAUTIONS). Hyperglycemia may occur. Glycosuria is a potential side effect. You might experience hyperuricemia. Muscle spasms can occur. You may feel vertigo. Paresthesias may happen. Dizziness is a possible side effect. Headaches can occur. Restlessness may be experienced. Erythema multiforme, including Stevens-Johnson syndrome, is a serious risk. Exfoliative dermatitis, including toxic epidermal necrolysis, may occur. Alopecia is a potential side effect. You might experience transient blurred vision. Xanthopsia may occur. There is a risk of renal failure. Renal dysfunction is a possible concern. Interstitial nephritis may occur. Hematuria may happen following intravenous use. Impotence is a potential side effect. Warnings intravenous use in infants and children has been limited and is not generally recommended use with caution in severe renal disease in patients with renal disease, thiazides may precipitate azotemia cumulative effects of the drug may develop in patients with impaired renal function thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease minor alterations of fluid and electrolyte balance may precipitate hepatic coma sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma the possibility of exacerbation or activation of systemic lupus erythematosus has been reported lithium generally should not be given with diuretics all patients receiving diuretic therapy should be observed for evidence of fluid or electrolyte imbalance warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting hypokalemia may develop especially with brisk diuresis, when severe cirrhosis is present or after prolonged therapy interference with adequate oral electrolyte intake will also contribute to hypokalemia hypokalemia may cause cardiac arrhythmias and may also sensitize or exaggerate the response of the heart to the toxic effects of digitalis hypokalemia may be avoided or treated by use of potassium-sparing diuretics or potassium supplements dilutional hyponatremia may occur in edematous patients in hot weather appropriate therapy is water restriction, rather than administration of salt, except in rare instances when the hyponatremia is life-threatening in actual salt depletion, appropriate replacement is the therapy of choice hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazides in diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required hyperglycemia may occur with thiazide diuretics latent diabetes mellitus may become manifest during thiazide therapy if progressive renal impairment becomes evident, consider withholding or discontinuing diuretic therapy thiazides have been shown to increase the urinary excretion of magnesium; this may result in hypo-magnesemia thiazides may decrease urinary calcium excretion marked hypercalcemia may be evidence of hidden hyperparathyroidism thiazides should be discontinued before carrying out tests for parathyroid function chlorothiazide should be used during pregnancy only if clearly needed chlorothiazide may cause fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions which have occurred in the adult a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother safety and effectiveness of chlorothiazide sodium for injection in pediatric patients have not been established care should be taken in dose selection for elderly patients the risk of toxic reactions to this drug may be greater in patients with impaired renal function Pregnancy & Lactation chlorothiazide should be used during pregnancy only if clearly needed chlorothiazide may cause fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions which have occurred in the adult a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialadenitis cramping constipation gastric irritation nausea anorexia aplastic anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance (see PRECAUTIONS) hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesias dizziness headache restlessness erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia transient blurred vision xanthopsia renal failure renal dysfunction interstitial nephritis hematuria (following intravenous use) impotence
Diovan Hct (valsartan and hydrochlorothiazide) Rx tablet, film coated Novartis Pharmaceuticals Corporation	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	8 pregnancy and lactation warnings	36 side effects	Trend: fell 19% over 11 months; peaks in Mar, Aug, Sep.
Diovan Hct® · First marketed 1998 · Label last revised December 12, 2025View full label details → Warnings If you find out you are pregnant, please stop taking Diovan HCT as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. Make sure to correct any volume depletion before starting treatment. Keep an eye out for any signs of fluid or electrolyte imbalance. Your healthcare provider should regularly monitor your renal function and potassium levels if you are at risk. Be aware that this medication may worsen or trigger systemic lupus erythematosus. Watch for symptoms of acute angle-closure glaucoma. Pregnancy & Lactation If you are pregnant, be aware that Diovan HCT can cause harm to the fetus. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy may reduce fetal kidney function and increase the risk of complications for both the fetus and newborn. If you find out you are pregnant, please discontinue Diovan HCT as soon as possible. Oligohydramnios in pregnant women using medications that affect the renin-angiotensin system during the second and third trimesters can lead to reduced fetal kidney function, which may result in anuria, renal failure, underdeveloped lungs, skeletal deformities (including skull hypoplasia), low blood pressure, and even death. Be cautious, as using thiazides during pregnancy is linked to a risk of fetal or neonatal jaundice or low platelet counts. These medications should not be used to manage hypertension in pregnant women. It's best to avoid using hydrochlorothiazide for other conditions (like heart disease) during pregnancy. If you are nursing, please be advised that breastfeeding is not recommended while you are being treated with Diovan HCT. Side Effects You may experience a headache. Dizziness can occur. There is a chance of nasopharyngitis (2.4% vs. 1.9%). Hypotension is a possible side effect. You might face fluid or electrolyte imbalance. Renal function impairment could happen. Patients who are susceptible may experience potassium imbalance. Exacerbation or activation of systemic lupus erythematosus may occur. Acute angle-closure glaucoma is a potential risk. Angioedema may develop. You could have elevated liver enzymes. Hepatitis is a possible side effect. Rhabdomyolysis may occur. Impaired renal function can happen. Alopecia might be experienced. Bullous dermatitis is a potential side effect. Vasculitis may develop. You might experience syncope. Acute renal failure is a possible risk. Renal disorder could occur. Aplastic anemia is a potential side effect. Erythema multiforme may develop. You might experience pyrexia. Muscle spasms can occur. Asthenia may be experienced. Bone marrow failure is a potential risk. Worsening of diabetes control may happen. Hypokalemia could occur. You may notice increased blood lipids. Hyponatremia is a possible side effect. Hypomagnesemia may develop. Hypercalcemia is a potential risk. Hypochloremic alkalosis could occur. Impotence may be experienced. Visual impairment is a possible side effect. Non-melanoma skin cancer may occur. Warnings when pregnancy is detected, discontinue Diovan HCT as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume depletion prior to initiation observe for signs of fluid or electrolyte imbalance monitor renal function and potassium in susceptible patients exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma Pregnancy & Lactation Diovan HCT can cause fetal harm when administered to a pregnant woman Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death When pregnancy is detected discontinue Diovan HCT as soon as possible Oligohydramnios in pregnant women who use drugs affecting the renin-angiotensin system in the second and third trimesters of pregnancy can result in reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension and death Use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia These drugs should not be used to treat hypertension in pregnant women The use of hydrochlorothiazide for other indications (e.g., heart disease) in pregnancy should be avoided Advise a nursing woman that breastfeeding is not recommended during treatment with Diovan HCT Side Effects headache dizziness nasopharyngitis (2.4% vs. 1.9%) hypotension fluid or electrolyte imbalance renal function impairment potassium imbalance in susceptible patients exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma angioedema elevated liver enzymes hepatitis rhabdomyolysis impaired renal function alopecia bullous dermatitis vasculitis syncope acute renal failure renal disorder aplastic anemia erythema multiforme pyrexia muscle spasm asthenia bone marrow failure worsening of diabetes control hypokalemia blood lipids increased hyponatremia hypomagnesemia hypercalcemia hypochloremic alkalosis impotence visual impairment non-melanoma skin cancer
Enalapril Maleate and Hydrochlorothiazide Rx tablet Taro Pharmaceuticals U. S. A. , Inc.	Popularity – score 0 out of 100 (least-viewed drug)	19 warnings	2 pregnancy and lactation warnings	121 side effects	Trend: rose 100% over the year; peak in May; bumpy overall.
Enalapril Maleate and Hydrochlorothiazide® · First marketed 2001 · Label last revised February 12, 2024View full label details → Warnings If you detect that you are pregnant, please discontinue enalapril maleate and hydrochlorothiazide as soon as possible. Medications that act directly on the renin-angiotensin system can cause injury and even death to a developing fetus. While excessive hypotension is rarely seen in uncomplicated hypertensive patients, it can occur with enalapril use in individuals who are severely salt or volume depleted, such as those being treated aggressively with diuretics or patients on dialysis. Syncope has been reported in 1.3 percent of patients taking enalapril maleate and hydrochlorothiazide. In patients with severe congestive heart failure, with or without renal insufficiency, excessive hypotension has been observed and may be linked to oliguria and/or progressive azotemia, and in rare cases, acute renal failure and/or death. If you have severe congestive heart failure, therapy should be started under very close medical supervision. You should be monitored closely for the first two weeks of treatment and whenever your dose of enalapril and/or diuretic is increased. Angioedema affecting the face, extremities, lips, tongue, glottis, and/or larynx has been reported in patients treated with angiotensin converting enzyme inhibitors, including enalapril. If you experience angioedema, enalapril maleate and hydrochlorothiazide should be discontinued promptly, and appropriate therapy and monitoring should be provided until complete and sustained resolution of signs and symptoms occurs. If you are taking both an ACE inhibitor and an mTOR inhibitor, you may be at increased risk for angioedema. Intestinal angioedema has been reported in patients treated with ACE inhibitors. If you have a history of angioedema unrelated to ACE inhibitor therapy, you may be at increased risk of angioedema while receiving an ACE inhibitor. You should report any signs of infection promptly, as this may indicate neutropenia. Please report any lightheadedness, especially during the first few days of therapy. If you experience actual syncope, please discontinue the drug until you have consulted with your prescribing physician. Do not use salt substitutes containing potassium without consulting your physician. If you are a female of childbearing age, please be aware of the consequences of exposure to enalapril maleate and hydrochlorothiazide during pregnancy. You should report any pregnancies to your physician as soon as possible. If you are taking hydrochlorothiazide, please protect your skin from the sun and undergo regular skin cancer screenings. Pregnancy & Lactation Enalapril, enalaprilat, and hydrochlorothiazide can be found in human breast milk. You should consider whether to continue nursing or to stop taking enalapril maleate and hydrochlorothiazide, keeping in mind how important the medication is for your health. Side Effects You may experience dizziness (8.6 percent). You might have a headache (5.5 percent). Fatigue (3.9 percent) could occur. Cough (3.5 percent) is another possible side effect. You may notice muscle cramps (2.7 percent). Nausea (2.5 percent) can happen. You might feel asthenia (2.4 percent). Orthostatic effects (2.3 percent) may be experienced. Impotence (2.2 percent) is a potential side effect. Diarrhea (2.1 percent) could occur. You may experience syncope. Chest pain might happen. You could feel abdominal pain. Orthostatic hypotension may occur. Palpitations could be experienced. Tachycardia might happen. You may experience vomiting. Dyspepsia could occur. Constipation might be a side effect. You may notice flatulence. Dry mouth could happen. Insomnia might occur. You may feel nervousness. Paresthesia could be experienced. Somnolence might happen. You may experience vertigo. Pruritus could occur. You might develop a rash. Dyspnea may be experienced. Gout could occur. You may feel back pain. Arthralgia might happen. Diaphoresis could occur. You may notice decreased libido. Tinnitus might be experienced. You could develop a urinary tract infection. Angioedema may occur. Hypotension might happen. Pulmonary embolism is a serious potential side effect. Myocardial infarction is a rare but serious risk. Cerebrovascular accident is a serious concern. Pulmonary edema may occur. Atrial tachycardia could happen. Bradycardia might be experienced. Atrial fibrillation is a potential side effect. Angina pectoris may occur. Raynaud's phenomenon could happen. Ileus might be experienced. Pancreatitis is a serious potential side effect. Hepatic failure is a rare but serious risk. Hepatitis may occur. Melena could happen. You may experience anorexia. Glossitis might occur. Stomatitis could be experienced. Dry mouth may happen. Depression is a potential side effect. You might feel confusion. Ataxia could occur. Peripheral neuropathy may be experienced. Dream abnormality might happen. Renal failure is a serious potential side effect. Oliguria could occur. Renal dysfunction may happen. You might feel flank pain. Gynecomastia could occur. Pulmonary infiltrates may be experienced. Eosinophilic pneumonitis is a serious concern. Bronchospasm might happen. Pneumonia could occur. Bronchitis may be experienced. Rhinorrhea might happen. You may have a sore throat. Hoarseness could occur. Asthma may be a concern. Upper respiratory infection might happen. Exfoliative dermatitis could occur. Toxic epidermal necrolysis is a serious potential side effect. Stevens-Johnson syndrome is a rare but serious risk. Herpes zoster may occur. Erythema multiforme could happen. Urticaria might be experienced. Pemphigus is a rare potential side effect. Alopecia may occur. Flushing could happen. Photosensitivity might be experienced. You may notice blurred vision. Taste alteration could occur. Anosmia might happen. Conjunctivitis may be experienced. Dry eyes could occur. Tearing might happen. You may feel weakness. Pancreatitis is a serious potential side effect. Jaundice could occur. Sialadenitis might happen. Cramping may be experienced. Gastric irritation could occur. You may experience anorexia. Aplastic anemia is a serious potential side effect. Agranulocytosis is a rare but serious risk. Leukopenia might happen. Hemolytic anemia could occur. Thrombocytopenia may be experienced. Purpura might happen. Photosensitivity could occur. Urticaria may be experienced. Necrotizing angiitis is a serious concern. You may experience fever. Respiratory distress could happen. Muscle spasm might occur. Restlessness may be experienced. Interstitial nephritis is a serious potential side effect. Erythema multiforme could happen. Stevens-Johnson syndrome is a rare but serious risk. Exfoliative dermatitis may occur. Alopecia might happen. Transient blurred vision could occur. Xanthopsia may be experienced. Acute transient myopia might happen. Acute angle-closure glaucoma is a serious concern. Warnings when pregnancy is detected, discontinue enalapril maleate and hydrochlorothiazide as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus excessive hypotension was rarely seen in uncomplicated hypertensive patients but is a possible consequence of enalapril use in severely salt/volume depleted persons such as those treated vigorously with diuretics or patients on dialysis syncope has been reported in 1.3 percent of patients receiving enalapril maleate and hydrochlorothiazide in patients with severe congestive heart failure, with or without associated renal insufficiency, excessive hypotension has been observed and may be associated with oliguria and/or progressive azotemia, and rarely with acute renal failure and/or death therapy should be started under very close medical supervision in patients with severe congestive heart failure patients should be followed closely for the first two weeks of treatment and whenever the dose of enalapril and/or diuretic is increased angioedema of the face, extremities, lips, tongue, glottis and/or larynx has been reported in patients treated with angiotensin converting enzyme inhibitors, including enalapril enalapril maleate and hydrochlorothiazide should be promptly discontinued and appropriate therapy and monitoring should be provided until complete and sustained resolution of signs and symptoms has occurred in cases of angioedema patients receiving coadministration of ACE inhibitor and mTOR inhibitor may be at increased risk for angioedema intestinal angioedema has been reported in patients treated with ACE inhibitors patients with a history of angioedema unrelated to ACE inhibitor therapy may be at increased risk of angioedema while receiving an ACE inhibitor patients should be told to report promptly any indication of infection which may be a sign of neutropenia patients should be told to report lightheadedness especially during the first few days of therapy if actual syncope occurs, the patients should be told to discontinue the drug until they have consulted with the prescribing physician patients should be told not to use salt substitutes containing potassium without consulting their physician female patients of childbearing age should be told about the consequences of exposure to enalapril maleate and hydrochlorothiazide during pregnancy patients should be asked to report pregnancies to their physicians as soon as possible instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening Pregnancy & Lactation enalapril, enalaprilat, and hydrochlorothiazide have been detected in human breast milk a decision should be made whether to discontinue nursing or to discontinue enalapril maleate and hydrochlorothiazide, taking into account the importance of the drug to the mother Side Effects dizziness (8.6 percent) headache (5.5 percent) fatigue (3.9 percent) cough (3.5 percent) muscle cramps (2.7 percent) nausea (2.5 percent) asthenia (2.4 percent) orthostatic effects (2.3 percent) impotence (2.2 percent) diarrhea (2.1 percent) syncope chest pain abdominal pain orthostatic hypotension palpitation tachycardia vomiting dyspepsia constipation flatulence dry mouth insomnia nervousness paresthesia somnolence vertigo pruritus rash dyspnea gout back pain arthralgia diaphoresis decreased libido tinnitus urinary tract infection angioedema hypotension pulmonary embolism myocardial infarction cerebrovascular accident pulmonary edema atrial tachycardia bradycardia atrial fibrillation angina pectoris Raynaud's phenomenon ileus pancreatitis hepatic failure hepatitis melena anorexia glossitis stomatitis dry mouth depression confusion ataxia peripheral neuropathy dream abnormality renal failure oliguria renal dysfunction flank pain gynecomastia pulmonary infiltrates eosinophilic pneumonitis bronchospasm pneumonia bronchitis rhinorrhea sore throat hoarseness asthma upper respiratory infection exfoliative dermatitis toxic epidermal necrolysis Stevens-Johnson syndrome herpes zoster erythema multiforme urticaria pemphigus alopecia flushing photosensitivity blurred vision taste alteration anosmia conjunctivitis dry eyes tearing weakness pancreatitis jaundice sialadenitis cramping gastric irritation anorexia aplasticanemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia purpura photosensitivity urticaria necrotizing angiitis fever respiratory distress muscle spasm restlessness interstitial nephritis erythema multiforme Stevens-Johnson syndrome exfoliative dermatitis alopecia transient blurred vision xanthopsia acute transient myopia acute angle-closure glaucoma
Enalapril Maleate and Hydrochlorothiazide Rx tablet Dr. Reddy's Laboratories Limited	Popularity – score 0 out of 100 (least-viewed drug)	19 warnings	3 pregnancy and lactation warnings	117 side effects	Trend: rose 100% over the year; peak in May; bumpy overall.
Enalapril Maleate and Hydrochlorothiazide® · First marketed 2001 · Label last revised October 4, 2010View full label details → Warnings If you are pregnant during the second and third trimesters, using ace inhibitors can harm your developing fetus and may even lead to death. If you find out you are pregnant, please stop taking enalapril maleate and hydrochlorothiazide tablets as soon as possible. While excessive hypotension is rarely seen in uncomplicated hypertensive patients, it can occur in individuals who are severely salt or volume depleted, such as those being treated aggressively with diuretics or patients on dialysis. Syncope has been reported in 1.3 percent of patients taking enalapril maleate and hydrochlorothiazide tablets. If you have severe congestive heart failure, with or without renal insufficiency, be aware that excessive hypotension has been observed, which may be linked to oliguria and/or progressive azotemia, and in rare cases, acute renal failure and/or death. Your therapy should begin under very close medical supervision. You should be monitored closely for the first two weeks of treatment and whenever your dose of enalapril and/or diuretic is increased. Angioedema affecting the face, extremities, lips, tongue, glottis, and/or larynx has been reported in patients treated with angiotensin converting enzyme inhibitors, including enalapril. If you experience such symptoms, please stop taking enalapril maleate and hydrochlorothiazide tablets immediately and seek appropriate therapy and monitoring until all signs and symptoms have completely resolved. If there is swelling of the tongue, glottis, or larynx that could obstruct your airway, prompt treatment, such as subcutaneous epinephrine solution 1:1000 (0.3 mL to 0.5 mL) and/or measures to ensure your airway remains open, should be provided. Intestinal angioedema has also been reported in patients treated with ace inhibitors. If you have a history of angioedema unrelated to ace inhibitor therapy, you may be at a higher risk of experiencing angioedema while taking an ace inhibitor. Please report any signs of infection, such as a sore throat or fever, to your healthcare provider promptly, as these may indicate neutropenia. Be sure to inform your healthcare provider if you feel lightheaded, especially during the first few days of therapy. If you experience actual syncope, please stop taking the medication and consult with your prescribing physician. All patients should be aware that excessive sweating and dehydration can lead to a significant drop in blood pressure due to reduced fluid volume. Do not use salt substitutes that contain potassium without first consulting your physician. If you are a female of childbearing age, it’s important to understand the potential consequences of exposure to ace inhibitors. Please inform your physician about any pregnancies as soon as possible. Pregnancy & Lactation Enalapril, enalaprilat, and hydrochlorothiazide can be found in human breast milk. You should consider whether to continue nursing or to stop taking enalapril maleate and hydrochlorothiazide tablets, keeping in mind how important the medication is for you. The pregnancy categories are C for the first trimester and D for the second and third trimesters. Side Effects You may experience dizziness (8.6 percent). You might have a headache (5.5 percent). Fatigue (3.9 percent) could be a concern for you. Coughing (3.5 percent) may occur. Muscle cramps (2.7 percent) can happen. Nausea (2.5 percent) is another possible side effect. You might feel asthenia (2.4 percent). Orthostatic effects (2.3 percent) may be experienced. Impotence (2.2 percent) could be a possibility. Diarrhea (2.1 percent) may occur. You might experience syncope. Chest pain could be a concern. Abdominal pain may happen. Orthostatic hypotension (1.5 percent) is something to watch for. Hypotension (0.9 percent) might occur. Vomiting could be a side effect. Dyspepsia may be experienced. Constipation might happen. You may notice flatulence. Dry mouth could be a concern. Insomnia may occur. Nervousness might be experienced. Paresthesia could happen. Somnolence may be a possibility. You might feel vertigo. Pruritus could occur. A rash may develop. Dyspnea might be experienced. Gout could be a concern. Back pain may happen. Arthralgia might occur. Diaphoresis could be experienced. Decreased libido may happen. Tinnitus might be a possibility. You may develop a urinary tract infection. Angioedema is a serious side effect to be aware of. Pulmonary embolism could occur. Myocardial infarction is a serious risk. A cerebrovascular accident may happen. Pulmonary edema could be a concern. Atrial tachycardia might occur. Bradycardia may be experienced. Atrial fibrillation could happen. Angina pectoris might be a possibility. Raynaud's phenomenon may occur. Ileus could be a concern. Pancreatitis might happen. Hepatic failure is a serious risk. Hepatitis may occur. Melena could be a possibility. Anorexia might be experienced. Glossitis may occur. Stomatitis could happen. You might experience dry mouth. Depression may be a concern. Confusion could occur. Ataxia might be experienced. Peripheral neuropathy may happen. Dream abnormality could be a possibility. Renal failure is a serious risk. Oliguria might occur. Renal dysfunction may happen. Flank pain could be a concern. Gynecomastia might occur. Pulmonary infiltrates may be experienced. Eosinophilic pneumonitis could happen. Bronchospasm might be a possibility. Pneumonia may occur. Bronchitis could be a concern. Rhinorrhea might happen. A sore throat may occur. Hoarseness could be experienced. Asthma might be a possibility. An upper respiratory infection may happen. Exfoliative dermatitis could occur. Toxic epidermal necrolysis is a serious risk. Stevens-Johnson syndrome may occur. Herpes zoster might happen. Erythema multiforme could be a concern. Urticaria may occur. Pemphigus might be experienced. Alopecia could happen. Flushing may be a possibility. Photosensitivity might occur. You may experience blurred vision. Taste alteration could happen. Anosmia might be a concern. Conjunctivitis may occur. Dry eyes could be experienced. Tearing might happen. Weakness may be a possibility. Pancreatitis could occur. Jaundice might be a concern. Sialadenitis may happen. Cramping could be experienced. Gastric irritation might occur. Anorexia may be a concern. Aplasia is a serious risk. Agranulocytosis could happen. Leukopenia might be experienced. Hemolytic anemia may occur. Thrombocytopenia could be a concern. Purpura might happen. Photosensitivity may occur. Urticaria could be experienced. Necrotizing angiitis might be a possibility. Fever may occur. Respiratory distress could happen. Muscle spasm might be a concern. Restlessness may occur. Interstitial nephritis could be a possibility. Erythema multiforme may happen. Stevens-Johnson syndrome is a serious risk. Exfoliative dermatitis might occur. Alopecia may be experienced. Transient blurred vision could happen. Xanthopsia might be a concern. Warnings when used in pregnancy during the second and third trimesters, ace inhibitors can cause injury and even death to the developing fetus when pregnancy is detected, enalapril maleate and hydrochlorothiazide tablets should be discontinued as soon as possible excessive hypotension was rarely seen in uncomplicated hypertensive patients but is a possible consequence of enalapril use in severely salt/volume depleted persons such as those treated vigorously with diuretics or patients on dialysis syncope has been reported in 1.3 percent of patients receiving enalapril maleate and hydrochlorothiazide tablets in patients with severe congestive heart failure, with or without associated renal insufficiency, excessive hypotension has been observed and may be associated with oliguria and/or progressive azotemia, and rarely with acute renal failure and/or death therapy should be started under very close medical supervision patients should be followed closely for the first two weeks of treatment and whenever the dose of enalapril and/or diuretic is increased angioedema of the face, extremities, lips, tongue, glottis and/or larynx has been reported in patients treated with angiotensin converting enzyme inhibitors, including enalapril in such cases enalapril maleate and hydrochlorothiazide tablets should be promptly discontinued and appropriate therapy and monitoring should be provided until complete and sustained resolution of signs and symptoms has occurred where there is involvement of the tongue, glottis or larynx, likely to cause airway obstruction, appropriate therapy, e.g., subcutaneous epinephrine solution 1:1000 (0.3 mL to 0.5 mL) and/or measures necessary to ensure a patent airway, should be promptly provided intestinal angioedema has been reported in patients treated with ace inhibitors patients with a history of angioedema unrelated to ace inhibitor therapy may be at increased risk of angioedema while receiving an ace inhibitor patients should be told to report promptly any indication of infection (e.g., sore throat, fever) which may be a sign of neutropenia patients should be told to report lightheadedness especially during the first few days of therapy if actual syncope occurs, the patients should be told to discontinue the drug until they have consulted with the prescribing physician all patients should be cautioned that excessive perspiration and dehydration may lead to an excessive fall in blood pressure because of reduction in fluid volume patients should be told not to use salt substitutes containing potassium without consulting their physician female patients of childbearing age should be told about the consequences of exposure to ace inhibitors these patients should be asked to report pregnancies to their physicians as soon as possible Pregnancy & Lactation enalapril, enalaprilat, and hydrochlorothiazide have been detected in human breast milk a decision should be made whether to discontinue nursing or to discontinue enalapril maleate and hydrochlorothiazide tablets, taking into account the importance of the drug to the mother pregnancy categories C (first trimester) and D (second and third trimesters) Side Effects dizziness (8.6 percent) headache (5.5 percent) fatigue (3.9 percent) cough (3.5 percent) muscle cramps (2.7 percent) nausea (2.5 percent) asthenia (2.4 percent) orthostatic effects (2.3 percent) impotence (2.2 percent) diarrhea (2.1 percent) syncope chest pain abdominal pain orthostatic hypotension (1.5 percent) hypotension (0.9 percent) vomiting dyspepsia constipation flatulence dry mouth insomnia nervousness paresthesia somnolence vertigo pruritus rash dyspnea gout back pain arthralgia diaphoresis decreased libido tinnitus urinary tract infection angioedema pulmonary embolism myocardial infarction cerebrovascular accident pulmonary edema atrial tachycardia bradycardia atrial fibrillation angina pectoris Raynaud's phenomenon ileus pancreatitis hepatic failure hepatitis melena anorexia glossitis stomatitis dry mouth depression confusion ataxia peripheral neuropathy dream abnormality renal failure oliguria renal dysfunction flank pain gynecomastia pulmonary infiltrates eosinophilic pneumonitis bronchospasm pneumonia bronchitis rhinorrhea sore throat hoarseness asthma upper respiratory infection exfoliative dermatitis toxic epidermal necrolysis Stevens-Johnson syndrome herpes zoster erythema multiforme urticaria pemphigus alopecia flushing photosensitivity blurred vision taste alteration anosmia conjunctivitis dry eyes tearing weakness pancreatitis jaundice sialadenitis cramping gastric irritation anorexia aplasia agranulocytosis leukopenia hemolytic anemia thrombocytopenia purpura photosensitivity urticaria necrotizing angiitis fever respiratory distress muscle spasm restlessness interstitial nephritis erythema multiforme Stevens-Johnson syndrome exfoliative dermatitis alopecia transient blurred vision xanthopsia
Exforge Hct (amlodipine valsartan and hydrochlorothiazide) Rx tablet, film coated Novartis Pharmaceuticals Corporation	Popularity – score 0 out of 100 (least-viewed drug)	8 warnings	9 pregnancy and lactation warnings	43 side effects	Trend: fell 12% over the year; peaks in Mar, May, Jun, Jul, Aug, Sep.
Exforge Hct® · First marketed 2009 · Label last revised December 12, 2025View full label details → Warnings If you find out you are pregnant, please stop taking Exforge HCT as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. Make sure to correct any volume depletion before starting treatment. Be aware that this medication may increase the risk of angina or myocardial infarction. Your healthcare provider should regularly monitor your renal function and potassium levels if you are at risk. This medication may worsen or trigger systemic lupus erythematosus. Keep an eye out for any signs of fluid or electrolyte imbalance. Be cautious of acute angle-closure glaucoma. Pregnancy & Lactation Exforge HCT can harm the fetus if you take it while pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase the risk of complications for both the fetus and newborn. If you find out you are pregnant, please stop taking Exforge HCT as soon as possible. Oligohydramnios in pregnant women using medications that impact the renin-angiotensin system during the second and third trimesters can lead to reduced fetal kidney function, resulting in anuria and renal failure, as well as fetal lung underdevelopment, skeletal deformities (including skull underdevelopment), low blood pressure, and even death. Thiazides can cross the placenta, and the levels in the umbilical vein can be similar to those in your bloodstream. Taking thiazides during pregnancy may increase the risk of fetal or neonatal jaundice or low platelet counts. These medications should not be used to manage hypertension in pregnant women. It's best to avoid using HCTZ for other conditions (like heart disease) during pregnancy. If you are breastfeeding, please inform your healthcare provider that breastfeeding is not recommended while you are being treated with Exforge HCT. Side Effects You may experience dizziness. You might notice peripheral edema. Headaches can occur. Dyspepsia may be a possibility. Fatigue is something to watch for. Muscle spasms could happen. You may feel back pain. Nausea is a potential side effect. Gynecomastia may occur. Jaundice is something to be aware of. Your healthcare provider may monitor hepatic enzyme elevations, which are mostly consistent with cholestasis or hepatitis. You might see a decrease in hemoglobin. A decrease in hematocrit could occur. Neutropenia is a possibility. Angioedema may happen. Elevated liver enzymes could be reported. There have been reports of hepatitis. Rhabdomyolysis is a rare but serious side effect. Impaired renal function may occur. Renal failure is a serious condition to be aware of. Alopecia could happen. Bullous dermatitis may occur. Vasculitis is a potential side effect. You might experience syncope. Acute renal failure is a serious concern. You may have a renal disorder. Aplastic anemia is a rare but serious condition. Erythema multiforme may occur. Pyrexia could be a possibility. Muscle spasms might happen. You may feel asthenia. Acute angle-closure glaucoma is a serious condition that requires monitoring by your healthcare provider. Bone marrow failure is a rare but serious side effect. Worsening of diabetes control may occur. Hypokalemia is something to be aware of. You might see increased blood lipids. Hyponatremia could happen. Hypomagnesemia is a potential side effect. Hypercalcemia may occur. Hypochloremic alkalosis is a rare condition to be aware of. Impotence may be a possibility. You might experience visual impairment. There is an increased risk of non-melanoma skin cancer. Warnings when pregnancy is detected, discontinue Exforge HCT as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume depletion prior to initiation increased angina and/or myocardial infarction monitor renal function and potassium in susceptible patients exacerbation or activation of systemic lupus erythematosus observe for signs of fluid or electrolyte imbalance acute angle-closure glaucoma Pregnancy & Lactation Exforge HCT can cause fetal harm when administered to a pregnant woman Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death When pregnancy is detected, discontinue Exforge HCT as soon as possible Oligohydramnios in pregnant women who use drugs affecting the renin-angiotensin system in the second and third trimesters of pregnancy can result in reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension and death Thiazides can cross the placenta, and concentrations reached in the umbilical vein approach those in the maternal plasma Use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia These drugs should not be used to treat hypertension in pregnant women The use of HCTZ for other indications (e.g., heart disease) in pregnancy should be avoided Advise a nursing woman that breastfeeding is not recommended during treatment with Exforge HCT Side Effects dizziness peripheral edema headache dyspepsia fatigue muscle spasms back pain nausea gynecomastia jaundice hepatic enzyme elevations (mostly consistent with cholestasis or hepatitis) decrease in hemoglobin decrease in hematocrit neutropenia angioedema elevated liver enzymes reports of hepatitis rhabdomyolysis impaired renal function renal failure alopecia bullous dermatitis vasculitis syncope acute renal failure renal disorder aplasticanemia erythema multiforme pyrexia muscle spasm asthenia acute angle-closure glaucoma bone marrow failure worsening of diabetes control hypokalemia blood lipids increased hyponatremia hypomagnesemia hypercalcemia hypochloremic alkalosis impotence visual impairment increased risk of non-melanoma skin cancer
Fosinopril Sodium and Hydrochlorothiazide Rx tablet Aurobindo Pharma Limited	Popularity – score 0 out of 100 (least-viewed drug)	20 warnings	2 pregnancy and lactation warnings	82 side effects	Trend: was flat over 11 months; peak in May.
Fosinopril Sodium and Hydrochlorothiazide® · First marketed 2009 · Label last revised April 28, 2024View full label details → Warnings If you find out you are pregnant, please stop taking fosinopril and hydrochlorothiazide as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially causing injury or even death. Angioedema affecting the face, extremities, lips, tongue, glottis, and larynx has been reported in individuals treated with angiotensin-converting enzyme inhibitors. If you experience laryngeal stridor or angioedema of the face, tongue, or glottis, discontinue fosinopril sodium and hydrochlorothiazide immediately and seek appropriate treatment right away. If there is a risk of airway obstruction due to involvement of the tongue, glottis, or larynx, prompt administration of appropriate therapy, such as a subcutaneous epinephrine injection (1:1000, 0.3 to 0.5 mL), is necessary. Intestinal angioedema has been reported in patients taking ACE inhibitors. You should promptly report any signs of infection, such as a sore throat or fever, as these could indicate neutropenia. Fosinopril sodium and hydrochlorothiazide can lead to symptomatic hypotension. Make sure to correct any volume and/or salt depletion before starting therapy with fosinopril sodium and hydrochlorothiazide. If you have congestive heart failure, you should be closely monitored during the first two weeks of treatment and whenever your dose of fosinopril or diuretic is increased. If you experience hypotension, lie down and, if necessary, receive treatment with an intravenous infusion of physiological saline. Use fosinopril sodium and hydrochlorothiazide with caution if you have severe renal disease. Your renal function should be monitored during the first few weeks of therapy if you have unilateral or bilateral renal artery stenosis. Do not use potassium supplements or salt substitutes containing potassium without consulting your prescribing physician. If you are taking fosinopril sodium and hydrochlorothiazide, be aware that lightheadedness can occur, especially during the first few days of treatment. If you experience syncope, discontinue fosinopril sodium and hydrochlorothiazide until you have consulted your physician. If you are taking hydrochlorothiazide, protect your skin from the sun and undergo regular skin cancer screenings. Use fosinopril sodium and hydrochlorothiazide with caution if you have impaired hepatic function or progressive liver disease. Be advised that inadequate fluid intake, excessive sweating, diarrhea, or vomiting can lead to a significant drop in blood pressure. Please report any pregnancies to your physician as soon as possible. Pregnancy & Lactation Both fosinopril and hydrochlorothiazide can be found in human milk. You should decide whether to continue nursing or to stop taking fosinopril sodium and hydrochlorothiazide, considering how important the medication is for your health. Side Effects You may experience a headache (0.3%). You might have a cough (0.3%). Fatigue could occur in about 0.2% of cases. Headaches have been reported in 7% of patients. Coughing has been noted in 5.6% of patients. Fatigue has been observed in 3.9% of patients. Dizziness may affect 3.2% of patients. An upper respiratory infection has been reported in 2.3% of patients. Musculoskeletal pain has been experienced by 2% of patients. You may feel chest pain. Weakness could be a concern. Fever may occur. You might experience a viral infection. Orthostatic hypotension has been seen in 1.8% of patients. Edema may develop. Flushing could happen. You might notice a rhythm disturbance. Syncope may occur. Pruritus could be experienced. A rash may develop. Sexual dysfunction is a possibility. You might notice a change in libido. A breast mass could be detected. Nausea or vomiting may occur. Diarrhea might be experienced. Dyspepsia or heartburn could happen. You may feel abdominal pain. Gastritis or esophagitis might occur. Angioedema is a possibility. Myalgia or muscle cramps may affect you. Somnolence could be experienced. Depression might occur. You may feel numbness or paresthesia. Sinus congestion could happen. Pharyngitis may be a concern. Rhinitis might occur. Tinnitus could be experienced. You may develop a urinary tract infection. Increased urinary frequency might occur. Dysuria could be a concern. Hyperkalemia may develop. Hypokalemia might occur. Hyponatremia could be a possibility. Hypochloremic alkalosis may occur. You might experience dryness of the mouth. Thirst could be an issue. Weakness may affect you. Lethargy might occur. Drowsiness could be experienced. Restlessness may be a concern. You might have muscle pains or cramps. Muscular fatigue could occur. Tachycardia may develop. Vomiting might be experienced. Pancreatitis could occur. Jaundice (intrahepatic cholestatic) may develop. Sialadenitis might occur. Cramping could be experienced. Gastric irritation may happen. Constipation might be a concern. Anorexia could occur. Aplasia anemia may develop. Agranulocytosis might occur. Leukopenia could be a possibility. Thrombocytopenia may develop. Hemolytic anemia might occur. Necrotizing angiitis could be a concern. Stevens-Johnson syndrome may develop. Respiratory distress might occur. Anaphylactic reactions could happen. Purpura may develop. Urticaria might occur. Photosensitivity could be experienced. Muscle spasms may affect you. You might feel vertigo. Lightheadedness could occur. Transient blurred vision may happen. Paresthesia might be experienced. Xanthopsia could occur. Weakness may affect you. Restlessness might be a concern. Non-melanoma skin cancer is a possibility. Warnings when pregnancy is detected, discontinue fosinopril and hydrochlorothiazide as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus angioedema of the face, extremities, lips, tongue, glottis, and larynx has been reported in patients treated with angiotensin-converting enzyme inhibitors if laryngeal stridor or angioedema of the face, tongue, or glottis occurs, treatment with fosinopril sodium and hydrochlorothiazide should be discontinued and appropriate therapy instituted immediately when involvement of the tongue, glottis, or larynx appears likely to cause airway obstruction, appropriate therapy, e.g., subcutaneous epinephrine injection 1:1000 (0.3 to 0.5 mL) should be promptly administered intestinal angioedema has been reported in patients treated with ACE inhibitors patients should be told to promptly report any indication of infection (e.g., sore throat, fever), which could be a sign of neutropenia fosinopril sodium and hydrochlorothiazide can cause symptomatic hypotension volume and/or salt depletion should be corrected before initiating therapy with fosinopril sodium and hydrochlorothiazide patients with congestive heart failure should be followed closely for the first 2 weeks of treatment and whenever the dose of fosinopril or diuretic is increased if hypotension occurs, the patient should be placed in a supine position, and, if necessary, treated with intravenous infusion of physiological saline fosinopril sodium and hydrochlorothiazide should be used with caution in patients with severe renal disease renal function should be monitored during the first few weeks of therapy in patients with unilateral or bilateral renal artery stenosis patients should be told not to use potassium supplements or salt substitutes containing potassium without consulting the prescribing physician patients receiving fosinopril sodium and hydrochlorothiazide should be cautioned that lightheadedness can occur, especially during the first days of therapy patients should be told that if syncope occurs, fosinopril sodium and hydrochlorothiazide should be discontinued until the physician has been consulted patients taking hydrochlorothiazide should protect skin from the sun and undergo regular skin cancer screening patients with impaired hepatic function or progressive liver disease should use fosinopril sodium and hydrochlorothiazide with caution patients should be advised that inadequate fluid intake, excessive perspiration, diarrhea, or vomiting can lead to an excessive fall in blood pressure patients should be told to report pregnancies to their physicians as soon as possible Pregnancy & Lactation both fosinopril and hydrochlorothiazide are excreted in human milk a decision should be made whether to discontinue nursing or to discontinue fosinopril sodium and hydrochlorothiazide, taking into account the importance of the drug to the mother Side Effects headache (0.3%) cough (0.3%) fatigue (0.2%) headache in 7% of patients cough in 5.6% of patients fatigue in 3.9% of patients dizziness in 3.2% of patients upper respiratory infection in 2.3% of patients musculoskeletal pain in 2% of patients chest pain weakness fever viral infection orthostatic hypotension (seen in 1.8% of patients) edema flushing rhythm disturbance syncope pruritus rash sexual dysfunction change in libido breast mass nausea/vomiting diarrhea dyspepsia/heartburn abdominal pain gastritis/esophagitis angioedema myalgia/muscle cramps somnolence depression numbness/paresthesia sinus congestion pharyngitis rhinitis tinnitus urinary tract infection urinary frequency dysuria hyperkalemia hypokalemia hyponatremia hypochloremic alkalosis dryness of mouth thirst weakness lethargy drowsiness restlessness muscle pains or cramps muscular fatigue tachycardia vomiting pancreatitis jaundice (intrahepatic cholestatic) sialadenitis cramping gastric irritation constipation anorexia aplasia anemia agranulocytosis leukopenia thrombocytopenia hemolytic anemia necrotizing angiitis Stevens-Johnson syndrome respiratory distress anaphylactic reactions purpura urticaria photosensitivity muscle spasm vertigo lightheadedness transient blurred vision paresthesia xanthopsia weakness restlessness non-melanoma skin cancer
Fosinopril Sodium and Hydrochlorothiazide Rx tablet CIPLA USA INC.	Popularity – score 0 out of 100 (least-viewed drug)	21 warnings	2 pregnancy and lactation warnings	93 side effects	Trend: was flat over 11 months; peak in May.
Fosinopril Sodium and Hydrochlorothiazide® · First marketed 2020 · Label last revised November 3, 2020View full label details → Warnings If you find out you are pregnant, please stop taking fosinopril and hydrochlorothiazide as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. Angioedema affecting the face, extremities, lips, tongue, glottis, and larynx has been reported in patients using angiotensin-converting enzyme inhibitors. If you experience laryngeal stridor or angioedema of the face, tongue, or glottis, stop taking fosinopril sodium and hydrochlorothiazide tablets immediately and seek appropriate treatment. Intestinal angioedema has also been reported in patients treated with ACE inhibitors. Fosinopril sodium and hydrochlorothiazide tablets can lead to symptomatic hypotension. You are more likely to experience symptomatic hypotension if you have been volume- or salt-depleted due to prolonged diuretic therapy, dietary salt restriction, dialysis, diarrhea, or vomiting. Use fosinopril sodium and hydrochlorothiazide tablets cautiously if you are taking other antihypertensive medications. If you have congestive heart failure, ACE inhibitor therapy may cause excessive hypotension, which could lead to oliguria, azotemia, and, in rare cases, acute renal failure and death. Be cautious when using fosinopril sodium and hydrochlorothiazide tablets if you have severe renal disease. When taking ACE inhibitors, expect potential changes in renal function if you are susceptible. Your healthcare provider should always assess renal function when evaluating your hypertension. Consider monitoring your white blood cell counts if you have collagen-vascular disease, especially if it is associated with impaired renal function. Please report any signs of infection, such as a sore throat or fever, to your healthcare provider promptly, as these could indicate neutropenia. If you are a female of childbearing age, it’s important to understand the risks of using fosinopril and hydrochlorothiazide during pregnancy. Make sure to inform your physician as soon as you find out you are pregnant. If you are taking fosinopril sodium and hydrochlorothiazide tablets, be aware that lightheadedness can occur, especially during the first few days of treatment, and report this to your prescribing physician. If you experience syncope, stop taking fosinopril sodium and hydrochlorothiazide tablets until you consult your physician. Do not use potassium supplements or salt substitutes containing potassium without first consulting your prescribing physician. Be aware that inadequate fluid intake, excessive sweating, diarrhea, or vomiting can lead to a significant drop in blood pressure, which may cause lightheadedness or syncope. If you are taking hydrochlorothiazide, protect your skin from the sun and schedule regular skin cancer screenings. Pregnancy & Lactation Both fosinopril and hydrochlorothiazide can be found in human milk. You should decide whether to continue nursing or to stop taking fosinopril sodium and hydrochlorothiazide tablets, considering how important the medication is for your health. Side Effects You may experience a headache (0.3%). You might have a cough (0.3%). Fatigue could occur in some individuals (0.2%). Chest pain may be reported. You might feel weakness. Fever can happen. A viral infection may occur. Your healthcare provider may monitor for orthostatic hypotension, which is seen in 1.8% of patients taking fosinopril sodium hydrochlorothiazide tablets and 0.3% of those on placebo. You might notice edema. Flushing could be a side effect. Rhythm disturbances may occur. You might experience syncope. Pruritus could happen. A rash may develop. Sexual dysfunction is a possibility. You may notice a change in libido. A breast mass could be reported. Nausea or vomiting may occur. Diarrhea might happen. Dyspepsia or heartburn could be experienced. You might have abdominal pain. Gastritis or esophagitis may occur. Angioedema is a potential side effect. You might experience myalgia or muscle cramps. Somnolence could happen. Depression may occur. You might feel numbness or paresthesia. Sinus congestion could be experienced. Pharyngitis may occur. Rhinitis might happen. Tinnitus could be reported. A urinary tract infection may occur. You might experience urinary frequency. Dysuria could happen. Your healthcare provider may check for serum electrolyte abnormalities. Neutropenia is a possibility. Angina may occur. Myocardial infarction is a serious risk. A cerebrovascular accident could happen. You might experience a hypertensive crisis. Hypotension may occur. Claudication could be reported. Urticaria might happen. Photosensitivity is a potential side effect. Gout may occur. Pancreatitis is a serious condition that could happen. Hepatitis may occur. Dysphagia could be experienced. You might have abdominal distention. Flatulence may occur. You might notice changes in appetite or weight. Dry mouth could happen. Lymphadenopathy may occur. You might experience arthralgia. Memory disturbances could happen. A tremor may occur. Confusion might be experienced. Mood changes could happen. Sleep disturbances may occur. Bronchospasm is a potential side effect. Laryngitis or hoarseness may occur. Epistaxis could happen. You might experience vision disturbances. Taste disturbances may occur. Eye irritation could happen. Renal insufficiency is a serious concern. Elevations of BUN and creatinine may occur. Leukopenia could happen. Eosinophilia may occur. Hyperkalemia is a potential side effect. Hypokalemia might happen. Hyponatremia could occur. Hypochloremic alkalosis may be experienced. You might notice dryness of mouth. Thirst could be a side effect. You may feel weakness. Lethargy might occur. Drowsiness could happen. Restlessness may be experienced. Muscle pains or cramps could occur. Muscular fatigue might happen. Tachycardia is a potential side effect. Vomiting may occur. Nausea could happen. A persistent nonreproductive cough might be experienced. Anaphylactoid reactions are a serious risk. Intestinal angioedema may occur. Hypotension could happen. Impaired renal function is a concern. Neutropenia or agranulocytosis may occur. Fetal toxicity is a serious risk. Impaired hepatic function could happen. Exacerbation or activation of systemic lupus erythematosus may occur. Warnings when pregnancy is detected, discontinue fosinopril and hydrochlorothiazide as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death due to the developing fetus angioedema of the face, extremities, lips, tongue, glottis and larynx has been reported in patients treated with angiotensin-converting enzyme inhibitors if laryngeal stridor or angioedema of the face, tongue, or glottis occurs, treatment with fosinopril sodium and hydrochlorothiazide tablets should be discontinued and appropriate therapy instituted immediately intestinal angioedema has been reported in patients treated with ACE inhibitors fosinopril sodium and hydrochlorothiazide tablets can cause symptomatic hypotension symptomatic hypotension is most likely to occur in patients who have been volume- and/or salt-depleted as a result of prolonged diuretic therapy, dietary salt restriction, dialysis, diarrhea, or vomiting fosinopril sodium and hydrochlorothiazide tablets should be used cautiously in patients receiving concomitant therapy with other antihypertensives in patients with congestive heart failure, ACE inhibitor therapy may cause excessive hypotension, which may be associated with oliguria, azotemia, and (rarely) with acute renal failure and death fosinopril sodium and hydrochlorothiazide tablets should be used with caution in patients with severe renal disease when the renin-angiotensin-aldosterone system is inhibited by ACE inhibitors, changes in renal function may be anticipated in susceptible individuals evaluation of the hypertensive patient should always include assessment of renal function monitoring of white blood cell counts should be considered in patients with collagen-vascular disease, especially if the disease is associated with impaired renal function patients should be told to promptly report any indication of infection (e.g., sore throat, fever), which could be a sign of neutropenia female patients of childbearing age should be told about the consequences of exposure to fosinopril and hydrochlorothiazide during pregnancy patients should be asked to report pregnancies to their physicians as soon as possible a patient receiving fosinopril sodium and hydrochlorothiazide tablets should be cautioned that lightheadedness can occur, especially during the first days of therapy, and that it should be reported to the prescribing physician if syncope occurs, fosinopril sodium and hydrochlorothiazide tablets should be discontinued until the physician has been consulted patients should be told not to use potassium supplements or salt substitutes containing potassium without consulting the prescribing physician patients should be cautioned that inadequate fluid intake, excessive perspiration, diarrhea, or vomiting can lead to an excessive fall in blood pressure, with the same consequences of lightheadedness and possible syncope instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening Pregnancy & Lactation both fosinopril and hydrochlorothiazide are excreted in human milk a decision should be made whether to discontinue nursing or to discontinue fosinopril sodium and hydrochlorothiazide tablets, taking into account the importance of the drug to the mother Side Effects headache (0.3%) cough (0.3%) fatigue (0.2%) chest pain weakness fever viral infection orthostatic hypotension (seen in 1.8% of fosinopril sodium hydrochlorothiazide tablet patients and 0.3% of placebo patients) edema flushing rhythm disturbance syncope pruritus rash sexual dysfunction change in libido breast mass nausea/vomiting diarrhea dyspepsia/heartburn abdominal pain gastritis/esophagitis angioedema myalgia/muscle cramps somnolence depression numbness/paresthesia sinus congestion pharyngitis rhinitis tinnitus urinary tract infection urinary frequency dysuria serum electrolytes abnormalities neutropenia angina myocardial infarction cerebrovascular accident hypertensive crisis hypotension claudication urticaria photosensitivity gout pancreatitis hepatitis dysphagia abdominal distention flatulence appetite/weight change dry mouth lymphadenopathy arthralgia memory disturbance tremor confusion mood change sleep disturbance bronchospasm laryngitis/hoarseness epistaxis vision disturbance taste disturbance eye irritation renal insufficiency elevations of BUN and creatinine leukopenia eosinophilia hyperkalemia hypokalemia hyponatremia hypochloremic alkalosis dryness of mouth thirst weakness lethargy drowsiness restlessness muscle pains or cramps muscular fatigue tachycardia vomiting nausea persistent nonreproductive cough anaphylactoid reactions intestinal angioedema hypotension impaired renal function neutropenia/agranulocytosis fetal toxicity impaired hepatic function exacerbation or activation of systemic lupus erythematosus
Inzirqo (hydrochlorothiazide) Rx powder, for suspension ANI Pharmaceuticals, Inc.	Popularity – score 0 out of 100 (least-viewed drug)	5 warnings	5 pregnancy and lactation warnings	10 side effects	Trend: edged 0% over 11 months.
Inzirqo® · First marketed 2025 · Label last revised December 16, 2025View full label details → Warnings Your healthcare provider may periodically check your kidney function. Your healthcare provider should monitor and correct your serum electrolytes before use and check them periodically. You should have your blood sugar, lipid levels, uric acid, and calcium levels monitored periodically. Be aware of the possibility of exacerbation or activation of systemic lupus erythematosus. Watch for signs of acute angle-closure glaucoma and acute myopia. Pregnancy & Lactation If you have untreated hypertension during pregnancy, it can lead to adverse outcomes for both you and your baby. There have been rare reports of jaundice, thrombocytopenia, and electrolyte imbalances in infants who were exposed to thiazide medications during pregnancy. Having hypertension during pregnancy increases your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. Hypertension can also increase the risk for your baby, including intrauterine growth restriction and intrauterine death. Higher doses of hydrochlorothiazide that cause significant diuresis may affect your milk production. Side Effects You may experience hypokalemia. You might have hyponatremia. Hypomagnesemia could occur. Be aware of the possibility of hyperglycemia. You may notice hyperuricemia. Hyperlipidemia is another potential side effect. You could experience hypotension. There is a chance of exacerbation or activation of systemic lupus erythematosus. Acute angle-closure glaucoma may develop. You might experience acute myopia. Warnings monitor kidney function periodically monitor and correct serum electrolytes prior to use and monitor periodically monitor blood sugar, lipid levels, uric acid and calcium levels periodically exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma and acute myopia Pregnancy & Lactation untreated hypertension during pregnancy can lead to adverse outcomes for the mother and the fetus there have been rare reports of jaundice, thrombocytopenia, and electrolyte imbalances in infants exposed to thiazide medications during pregnancy hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death doses of hydrochlorothiazide associated with clinically significant diuresis have been associated with impaired milk production Side Effects hypokalemia hyponatremia hypomagnesemia hyperglycemia hyperuricemia hyperlipidemia hypotension exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma acute myopia
Irbesartan and Hydrochlorothiazide Rx tablet Hikma Pharmaceuticals USA Inc.	Popularity – score 0 out of 100 (least-viewed drug)	6 warnings	7 pregnancy and lactation warnings	9 side effects	Trend: was flat over 11 months; peaks in Oct, Dec; low in Apr.
Irbesartan and Hydrochlorothiazide® · First marketed 2012 · Label last revised December 1, 2025View full label details → Warnings If you find out you are pregnant, please stop taking irbesartan and hydrochlorothiazide as soon as possible. Medications that directly affect the renin-angiotensin system can harm your developing fetus. Make sure to correct any volume depletion before starting treatment. Be aware of any impaired renal function you may have. Thiazide diuretics can worsen or trigger systemic lupus erythematosus. Watch for signs of acute angle-closure glaucoma, acute myopia, and choroidal effusion. Pregnancy & Lactation If you are pregnant, be aware that irbesartan and hydrochlorothiazide can cause harm to the fetus. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase the risk of complications for both the fetus and newborn. Once you confirm your pregnancy, please discontinue irbesartan and hydrochlorothiazide tablets as soon as possible. Hypertension during pregnancy can increase your risk for preeclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also raise the risk for the fetus, including intrauterine growth restriction and intrauterine death. If you are pregnant and using medications that affect the renin-angiotensin system during the second and third trimesters, oligohydramnios may occur, which can lead to reduced kidney function in the fetus, resulting in anuria, renal failure, underdeveloped lungs, skeletal deformities (including skull hypoplasia), low blood pressure, and even death. Thiazides can cross the placenta, and using them during pregnancy may be associated with risks such as fetal or neonatal jaundice, low platelet counts, and possibly other adverse reactions. Side Effects You may experience dizziness. You might feel fatigued. You could have musculoskeletal pain. You may notice low blood pressure (hypotension). There is a possibility of impaired renal function. Thiazide diuretics may lead to an exacerbation or activation of systemic lupus erythematosus. Be aware that acute angle-closure glaucoma can occur. You might experience acute myopia. Choroidal effusion is another potential side effect. Warnings when pregnancy is detected, discontinue irbesartan and hydrochlorothiazide as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume depletion prior to administration impaired renal function thiazide diuretics may cause an exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma, acute myopia, and choroidal effusion Pregnancy & Lactation irbesartan and hydrochlorothiazide can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue irbesartan and hydrochlorothiazide tablets as soon as possible hypertension in pregnancy increases the maternal risk for preeclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death oligohydramnios in pregnant women who use drugs affecting the renin-angiotensin system in the second and third trimesters of pregnancy can result in reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death thiazides cross the placenta, and use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions Side Effects dizziness fatigue musculoskeletal pain hypotension impaired renal function thiazide diuretics may cause an exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma acute myopia choroidal effusion
Irbesartan and Hydrochlorothiazide Rx tablet, film coated Unichem Pharmaceuticals (USA) , Inc.	Popularity – score 0 out of 100 (least-viewed drug)	6 warnings	7 pregnancy and lactation warnings	9 side effects	Trend: was flat over 11 months; peaks in Oct, Dec; low in Apr.
Irbesartan and Hydrochlorothiazide® · First marketed 2017 · Label last revised December 18, 2025View full label details → Warnings If you find out you are pregnant, please stop taking irbesartan and hydrochlorothiazide tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm your developing fetus, potentially leading to serious injury or death. Make sure to correct any volume depletion before starting treatment. Be aware of any impaired renal function you may have. Thiazide diuretics can worsen or trigger systemic lupus erythematosus. Watch for signs of acute angle-closure glaucoma, acute myopia, and choroidal effusion. Pregnancy & Lactation If you are pregnant, be aware that irbesartan and hydrochlorothiazide can cause harm to the fetus. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase the risk of complications for both the fetus and newborn. As soon as you find out you are pregnant, please discontinue irbesartan and hydrochlorothiazide as quickly as possible. Having high blood pressure during pregnancy raises your risk for conditions like preeclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for the fetus, including issues like intrauterine growth restriction and intrauterine death. If you are pregnant and using medications that affect the renin-angiotensin system during the second and third trimesters, be aware that this can lead to oligohydramnios, which may result in reduced kidney function in the fetus, leading to anuria, renal failure, underdeveloped lungs, skeletal deformities (including skull hypoplasia), low blood pressure, and even death. Thiazides can cross the placenta, and using them during pregnancy may carry a risk of fetal or neonatal jaundice, low platelet counts, and possibly other adverse reactions. Side Effects You may experience dizziness. You might feel fatigued. You could have musculoskeletal pain. You may notice low blood pressure (hypotension). There is a possibility of impaired renal function. Thiazide diuretics may lead to an exacerbation or activation of systemic lupus erythematosus. Be aware that acute angle-closure glaucoma can occur. You might experience acute myopia. Choroidal effusion is another potential side effect. Warnings when pregnancy is detected, discontinue irbesartan and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume depletion prior to administration impaired renal function thiazide diuretics may cause an exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma, acute myopia, and choroidal effusion Pregnancy & Lactation irbesartan and hydrochlorothiazide can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue irbesartan and hydrochlorothiazide as soon as possible hypertension in pregnancy increases the maternal risk for preeclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death oligohydramnios in pregnant women who use drugs affecting the renin-angiotensin system in the second and third trimesters of pregnancy can result in reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death thiazides cross the placenta, and use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions Side Effects dizziness fatigue musculoskeletal pain hypotension impaired renal function thiazide diuretics may cause an exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma acute myopia choroidal effusion
Irbesartan and Hydrochlorothiazide Rx tablet, film coated Macleods Pharmaceuticals Limited	Popularity – score 0 out of 100 (least-viewed drug)	6 warnings	8 pregnancy and lactation warnings	9 side effects	Trend: was flat over 11 months; peaks in Oct, Dec; low in Apr.
Irbesartan and Hydrochlorothiazide® · First marketed 2012 · Label last revised September 2, 2025View full label details → Warnings If you find out you are pregnant, please stop taking irbesartan and hydrochlorothiazide tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm your developing fetus, potentially leading to serious injury or death. Make sure to correct any volume depletion before starting treatment. Be aware of any impaired renal function you may have. Thiazide diuretics can worsen or trigger systemic lupus erythematosus. Watch for signs of acute angle-closure glaucoma, acute myopia, and choroidal effusion. Pregnancy & Lactation If you are pregnant, be aware that irbesartan and hydrochlorothiazide tablets can cause harm to the fetus. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase the risk of complications for both the fetus and newborn. Once you confirm your pregnancy, please discontinue irbesartan and hydrochlorothiazide tablets as soon as possible. If you have hypertension during pregnancy, it may increase your risk for preeclampsia, gestational diabetes, premature delivery, and complications during delivery. Hypertension can also raise the risk for the fetus, including intrauterine growth restriction and intrauterine death. If you are pregnant and using medications that affect the renin-angiotensin system during the second and third trimesters, oligohydramnios may occur, which can lead to reduced fetal kidney function, anuria, renal failure, fetal lung hypoplasia, skeletal deformations such as skull hypoplasia, hypotension, and even death. Thiazides can cross the placenta, and using thiazides during pregnancy may carry a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. It is not recommended for breastfeeding women to use irbesartan and hydrochlorothiazide tablets. Side Effects You may experience dizziness. You might feel fatigued. You could have musculoskeletal pain. You may notice low blood pressure. There is a possibility of impaired renal function. Thiazide diuretics may lead to an exacerbation or activation of systemic lupus erythematosus. Be aware of the risk of acute angle-closure glaucoma. You might experience acute myopia. Choroidal effusion could occur. Warnings when pregnancy is detected, discontinue irbesartan and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume depletion prior to administration impaired renal function thiazide diuretics may cause an exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma, acute myopia, and choroidal effusion Pregnancy & Lactation irbesartan and hydrochlorothiazide tablets can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue irbesartan and hydrochlorothiazide tablets as soon as possible hypertension in pregnancy increases the maternal risk for preeclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death oligohydramnios in pregnant women who use drugs affecting the renin-angiotensin system in the second and third trimesters of pregnancy can result in reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death thiazides cross the placenta, and use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults the use of irbesartan and hydrochlorothiazide tablets in breastfeeding women is not recommended Side Effects dizziness fatigue musculoskeletal pain hypotension impaired renal function thiazide diuretics may cause an exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma acute myopia choroidal effusion
Irbesartan and Hydrochlorothiazide Rx tablet, film coated Aurobindo Pharma Limited	Popularity – score 0 out of 100 (least-viewed drug)	6 warnings	8 pregnancy and lactation warnings	9 side effects	Trend: was flat over 11 months; peaks in Oct, Dec; low in Apr.
Irbesartan and Hydrochlorothiazide® · First marketed 2013 · Label last revised December 19, 2025View full label details → Warnings If you find out you are pregnant, please stop taking irbesartan and hydrochlorothiazide as soon as possible. Medications that directly affect the renin-angiotensin system can harm your developing fetus, potentially leading to serious injury or death. Make sure to correct any volume depletion before starting treatment. Be aware of any impaired renal function you may have. Thiazide diuretics can worsen or trigger systemic lupus erythematosus. Watch for signs of acute angle-closure glaucoma, acute myopia, and choroidal effusion. Pregnancy & Lactation If you are pregnant, be aware that irbesartan and hydrochlorothiazide can cause harm to the fetus. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase the risk of complications for both the fetus and newborn. Once you confirm your pregnancy, please discontinue irbesartan and hydrochlorothiazide as soon as possible. Hypertension during pregnancy can increase your risk for preeclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also raise the risk for the fetus, including intrauterine growth restriction and intrauterine death. If you are pregnant and using medications that affect the renin-angiotensin system during the second and third trimesters, oligohydramnios may occur, which can lead to reduced kidney function in the fetus, resulting in anuria, renal failure, underdeveloped lungs, skeletal deformities such as skull hypoplasia, low blood pressure, and even death. Thiazides can cross the placenta, and using them during pregnancy may carry a risk of fetal or neonatal jaundice, low platelet counts, and possibly other adverse reactions that have been seen in adults. If you are breastfeeding, it is not recommended to use irbesartan and hydrochlorothiazide due to the potential for adverse effects on your nursing infant. Side Effects You may experience dizziness. You might feel fatigued. You could have musculoskeletal pain. You may notice low blood pressure (hypotension). There is a possibility of impaired renal function. Thiazide diuretics may lead to an exacerbation or activation of systemic lupus erythematosus. Be aware that acute angle-closure glaucoma can occur. You might experience acute myopia. Choroidal effusion is also a potential side effect. Warnings when pregnancy is detected, discontinue irbesartan and hydrochlorothiazide as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume depletion prior to administration impaired renal function thiazide diuretics may cause an exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma, acute myopia, and choroidal effusion Pregnancy & Lactation irbesartan and hydrochlorothiazide can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue irbesartan and hydrochlorothiazide as soon as possible hypertension in pregnancy increases the maternal risk for preeclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death oligohydramnios in pregnant women who use drugs affecting the renin-angiotensin system in the second and third trimesters of pregnancy can result in reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death thiazides cross the placenta, and use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults the use of irbesartan and hydrochlorothiazide in breastfeeding women is not recommended due to the potential for adverse effects on the nursing infant Side Effects dizziness fatigue musculoskeletal pain hypotension impaired renal function thiazide diuretics may cause an exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma acute myopia choroidal effusion
Irbesartan and Hydrochlorothiazide Rx tablet Solco Healthcare US, LLC	Popularity – score 0 out of 100 (least-viewed drug)	6 warnings	7 pregnancy and lactation warnings	9 side effects	Trend: was flat over 11 months; peaks in Oct, Dec; low in Apr.
Irbesartan and Hydrochlorothiazide® · First marketed 2014 · Label last revised June 27, 2023View full label details → Warnings If you find out you are pregnant, please stop taking irbesartan and hydrochlorothiazide tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm your developing fetus, potentially leading to serious injury or death. Make sure to correct any volume depletion before starting treatment. Be aware of any impaired renal function you may have. Thiazide diuretics can worsen or trigger systemic lupus erythematosus. Watch for signs of acute angle-closure glaucoma, acute myopia, and choroidal effusion. Pregnancy & Lactation If you are pregnant, be aware that irbesartan and hydrochlorothiazide tablets can cause harm to the fetus. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please stop taking irbesartan and hydrochlorothiazide tablets as soon as possible. Having high blood pressure during pregnancy raises your risk for preeclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for your baby of intrauterine growth restriction and intrauterine death. If you are pregnant and using medications that affect the renin-angiotensin system during the second and third trimesters, it can lead to oligohydramnios, which may result in reduced kidney function in the fetus, anuria, renal failure, underdeveloped lungs, skeletal deformities including skull hypoplasia, low blood pressure, and even death. Thiazides can cross the placenta, and using thiazides during pregnancy may be linked to a risk of fetal or neonatal jaundice, low platelet counts, and possibly other adverse reactions. Side Effects You may experience dizziness. You might feel fatigued. You could have musculoskeletal pain. You may notice low blood pressure. There is a possibility of impaired renal function. Thiazide diuretics may lead to an exacerbation or activation of systemic lupus erythematosus. Be aware that acute angle-closure glaucoma can occur. You might experience acute myopia. Choroidal effusion is another potential side effect. Warnings when pregnancy is detected, discontinue irbesartan and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume-depletion prior to administration impaired renal function thiazide diuretics may cause an exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma, acute myopia, and choroidal effusion Pregnancy & Lactation irbesartan and hydrochlorothiazide tablets can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue irbesartan and hydrochlorothiazide tablets as soon as possible hypertension in pregnancy increases the maternal risk for preeclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death oligohydramnios in pregnant women who use drugs affecting the renin-angiotensin system in the second and third trimesters of pregnancy can result in reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death thiazides cross the placenta, and use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions Side Effects dizziness fatigue musculoskeletal pain hypotension impaired renal function thiazide diuretics may cause an exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma acute myopia choroidal effusion
Irbesartan and Hydrochlorothiazide Rx tablet, film coated Teva Pharmaceuticals USA, Inc.	Popularity – score 0 out of 100 (least-viewed drug)	6 warnings	7 pregnancy and lactation warnings	9 side effects	Trend: was flat over 11 months; peaks in Oct, Dec; low in Apr.
Irbesartan and Hydrochlorothiazide® · First marketed 2013 · Label last revised October 1, 2021View full label details → Warnings If you find out you are pregnant, please stop taking irbesartan and hydrochlorothiazide tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. Make sure to correct any volume depletion before starting treatment. Be aware of any impaired renal function you may have. Thiazide diuretics can worsen or trigger systemic lupus erythematosus. Watch for signs of acute angle-closure glaucoma, acute myopia, and choroidal effusion. Pregnancy & Lactation Irbesartan and hydrochlorothiazide can cause harm to the fetus if you take them while pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please stop taking irbesartan and hydrochlorothiazide as soon as possible. High blood pressure during pregnancy raises your risk for preeclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for your baby of intrauterine growth restriction and intrauterine death. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can lead to oligohydramnios, which may result in reduced kidney function in the fetus, leading to anuria, renal failure, underdeveloped lungs, skeletal deformities (including skull hypoplasia), low blood pressure, and even death. Thiazides can cross the placenta, and using them during pregnancy may be associated with a risk of jaundice, low platelet counts, and possibly other adverse reactions in your baby. Side Effects You may experience dizziness. You might feel fatigued. You could have musculoskeletal pain. You may notice low blood pressure (hypotension). There is a possibility of impaired renal function. Thiazide diuretics may lead to an exacerbation or activation of systemic lupus erythematosus. Be aware that acute angle-closure glaucoma can occur. You might experience acute myopia. Choroidal effusion is another potential side effect. Warnings when pregnancy is detected, discontinue irbesartan and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume depletion prior to administration impaired renal function thiazide diuretics may cause an exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma, acute myopia, and choroidal effusion Pregnancy & Lactation irbesartan and hydrochlorothiazide can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue irbesartan and hydrochlorothiazide as soon as possible hypertension in pregnancy increases the maternal risk for preeclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death oligohydramnios in pregnant women who use drugs affecting the renin-angiotensin system in the second and third trimesters of pregnancy can result in reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death thiazides cross the placenta, and use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions Side Effects dizziness fatigue musculoskeletal pain hypotension impaired renal function thiazide diuretics may cause an exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma acute myopia choroidal effusion
Irbesartan and Hydrochlorothiazide Rx tablet REMEDYREPACK INC.	Popularity – score 0 out of 100 (least-viewed drug)	6 warnings	7 pregnancy and lactation warnings	9 side effects	Trend: was flat over 11 months; peaks in Oct, Dec; low in Apr.
Irbesartan and Hydrochlorothiazide® · First marketed 2018 · Label last revised August 28, 2025View full label details → Warnings If you find out you are pregnant, please stop taking irbesartan and hydrochlorothiazide tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm your developing fetus, potentially leading to serious injury or death. Make sure to correct any volume depletion before starting treatment. Be aware of any impaired renal function you may have. Thiazide diuretics can worsen or trigger systemic lupus erythematosus. Watch for signs of acute angle-closure glaucoma, acute myopia, and choroidal effusion. Pregnancy & Lactation If you are pregnant, be aware that irbesartan and hydrochlorothiazide tablets can cause harm to the fetus. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase the risk of complications for both the fetus and newborn. If you find out you are pregnant, please discontinue irbesartan and hydrochlorothiazide tablets as soon as possible. Having high blood pressure during pregnancy can increase your risk for preeclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also raise the risk for the fetus of experiencing intrauterine growth restriction and intrauterine death. If you are pregnant and using medications that affect the renin-angiotensin system during the second and third trimesters, oligohydramnios may occur, which can lead to reduced fetal kidney function, anuria, renal failure, underdeveloped lungs, skeletal deformities (including skull hypoplasia), low blood pressure, and even death. Thiazides can cross the placenta, and using thiazides during pregnancy may be associated with a risk of fetal or neonatal jaundice, low platelet counts, and possibly other adverse reactions that have been observed in adults. Side Effects You may experience dizziness. You might feel fatigued. You could have musculoskeletal pain. You may notice low blood pressure. There is a possibility of impaired renal function. Thiazide diuretics may lead to an exacerbation or activation of systemic lupus erythematosus. Be aware that acute angle-closure glaucoma can occur. You might experience acute myopia. Choroidal effusion is a potential side effect. Warnings when pregnancy is detected, discontinue irbesartan and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume-depletion prior to administration impaired renal function thiazide diuretics may cause an exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma, acute myopia, and choroidal effusion Pregnancy & Lactation irbesartan and hydrochlorothiazide tablets can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue irbesartan and hydrochlorothiazide tablets as soon as possible hypertension in pregnancy increases the maternal risk for preeclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death oligohydramnios in pregnant women who use drugs affecting the renin-angiotensin system in the second and third trimesters of pregnancy can result in reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death thiazides cross the placenta, and use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults Side Effects dizziness fatigue musculoskeletal pain hypotension impaired renal function thiazide diuretics may cause an exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma acute myopia choroidal effusion
Irbesartan and Hydrochlorothiazide Rx tablet Alembic Pharmaceuticals Limited	Popularity – score 0 out of 100 (least-viewed drug)	6 warnings	9 pregnancy and lactation warnings	7 side effects	Trend: was flat over 11 months; peaks in Oct, Dec; low in Apr.
Irbesartan and Hydrochlorothiazide® · First marketed 2016 · Label last revised January 30, 2023View full label details → Warnings If you find out you are pregnant, please stop taking irbesartan and hydrochlorothiazide tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm your developing fetus, potentially leading to serious injury or death. Make sure to correct any volume depletion before starting treatment. Be aware of any impaired renal function you may have. Thiazide diuretics can worsen or trigger systemic lupus erythematosus. Watch for symptoms of acute myopia and secondary angle-closure glaucoma. Pregnancy & Lactation Using drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal renal function and increase the risk of morbidity and death for both the fetus and neonate. If you find out you are pregnant, please discontinue Irbesartan and Hydrochlorothiazide Tablets as soon as possible. In the rare case that there is no suitable alternative to therapy with drugs affecting the renin-angiotensin system for your specific situation, make sure to discuss the potential risks to your fetus with your healthcare provider. If oligohydramnios is observed, you should stop taking Irbesartan and Hydrochlorothiazide Tablets, unless your healthcare provider considers it lifesaving for you. Your healthcare provider should closely monitor infants who have been exposed to Irbesartan and Hydrochlorothiazide Tablets in utero for signs of hypotension, oliguria, and hyperkalemia. Irbesartan has been shown to cross the placenta in studies with rats and rabbits. Pregnant rabbits that received oral doses of irbesartan equivalent to 1.5 times the maximum recommended human dose experienced a high rate of maternal mortality and abortion. Radioactivity was detected in the fetuses of rats and rabbits during late gestation, as well as in rat milk following oral doses of radiolabeled irbesartan. You and your healthcare provider should decide whether to continue nursing or discontinue the drug, considering how important the medication is for your health. Side Effects You may experience dizziness. You might feel fatigued. You could have musculoskeletal pain. Be aware that hypotension may occur. Your renal function may be impaired. Thiazide diuretics may lead to an exacerbation or activation of systemic lupus erythematosus. You may develop acute myopia and secondary angle-closure glaucoma. Warnings when pregnancy is detected, discontinue irbesartan and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume-depletion prior to administration impaired renal function thiazide diuretics may cause an exacerbation or activation of systemic lupus erythematosus acute myopia and secondary angle-closure glaucoma Pregnancy & Lactation use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue Irbesartan and Hydrochlorothiazide Tablets as soon as possible in the unusual case that there is no appropriate alternative to therapy with drugs affecting the renin-angiotensin system for a particular patient, apprise the mother of the potential risk to the fetus if oligohydramnios is observed, discontinue Irbesartan and Hydrochlorothiazide Tablets, unless it is considered lifesaving for the mother closely observe infants with histories of in utero exposure to Irbesartan and Hydrochlorothiazide Tablets for hypotension, oliguria, and hyperkalemia irbesartan crosses the placenta in rats and rabbits pregnant rabbits given oral doses of irbesartan equivalent to 1.5 times the MRHD experienced a high rate of maternal mortality and abortion radioactivity was present in the rat and rabbit fetus during late gestation and in rat milk following oral doses of radiolabeled irbesartan a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother Side Effects dizziness fatigue musculoskeletal pain hypotension impaired renal function thiazide diuretics may cause an exacerbation or activation of systemic lupus erythematosus acute myopia and secondary angle-closure glaucoma
Irbesartan and Hydrochlorothiazide Rx tablet, film coated Hisun Pharmaceuticals USA Inc.	Popularity – score 0 out of 100 (least-viewed drug)	6 warnings	9 pregnancy and lactation warnings	7 side effects	Trend: was flat over 11 months; peaks in Oct, Dec; low in Apr.
Irbesartan and Hydrochlorothiazide® · First marketed 2025 · Label last revised January 27, 2025View full label details → Warnings If you find out you are pregnant, please stop taking ibesartan and hydrochlorothiazide as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. Make sure to correct any volume depletion before starting treatment. Be aware of any impaired renal function you may have. Thiazide diuretics can worsen or trigger systemic lupus erythematosus. Watch for signs of secondary acute angle-closure glaucoma and/or acute myopia. Pregnancy & Lactation Using drugs that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal renal function and increase the risk of morbidity and mortality for both the fetus and neonate. If you find out you are pregnant, please discontinue irbesartan and hydrochlorothiazide as soon as possible. In the rare case that there are no suitable alternatives to therapy with drugs affecting the renin-angiotensin system for your specific situation, it's important to discuss the potential risks to your fetus with your healthcare provider. If oligohydramnios is detected, you should stop taking irbesartan and hydrochlorothiazide, unless your healthcare provider considers it lifesaving for you. Your healthcare provider should closely monitor infants who have been exposed to irbesartan and hydrochlorothiazide in utero for signs of hypotension, oliguria, and hyperkalemia. Irbesartan can cross the placenta in animal studies involving rats and rabbits. Pregnant rabbits that received oral doses of irbesartan equivalent to 1.5 times the maximum recommended human dose experienced a high rate of maternal mortality and abortion. Radioactivity was found in the fetuses of rats and rabbits during late gestation, as well as in rat milk after oral doses of radiolabeled irbesartan. You and your healthcare provider should decide whether to continue nursing or to discontinue the drug, considering the importance of the medication for your health. Side Effects You may experience dizziness. You might feel fatigued. You could have musculoskeletal pain. You may notice low blood pressure. There is a possibility of impaired renal function. Thiazide diuretics may lead to an exacerbation or activation of systemic lupus erythematosus. Be aware that secondary acute angle-closure glaucoma and/or acute myopia may occur. Warnings when pregnancy is detected, discontinue ibesartan and hydrochlorothiazide as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume-depletion prior to administration impaired renal function thiazide diuretics may cause an exacerbation or activation of systemic lupus erythematosus secondary acute angle-closure glaucoma and/or acute myopia Pregnancy & Lactation use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue irbesartan and hydrochlorothiazide as soon as possible in the unusual case that there is no appropriate alternative to therapy with drugs affecting the renin-angiotensin system for a particular patient, apprise the mother of the potential risk to the fetus if oligohydramnios is observed, discontinue irbesartan and hydrochlorothiazide, unless it is considered lifesaving for the mother closely observe infants with histories of in utero exposure to irbesartan and hydrochlorothiazide for hypotension, oliguria, and hyperkalemia irbesartan crosses the placenta in rats and rabbits pregnant rabbits given oral doses of irbesartan equivalent to 1.5 times the MRHD experienced a high rate of maternal mortality and abortion radioactivity was present in the rat and rabbit fetus during late gestation and in rat milk following oral doses of radiolabeled irbesartan a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother Side Effects dizziness fatigue musculoskeletal pain hypotension impaired renal function thiazide diuretics may cause an exacerbation or activation of systemic lupus erythematosus secondary acute angle-closure glaucoma and/or acute myopia
Lisinopril and Hydrochlorothiazide Rx tablet REMEDYREPACK INC.	Popularity – score 0 out of 100 (least-viewed drug)	14 warnings	2 pregnancy and lactation warnings	159 side effects	Trend: rose 46% over 11 months.
Lisinopril and Hydrochlorothiazide® · First marketed 2017 · Label last revised January 9, 2026View full label details → Warnings If you find out you are pregnant, please stop taking lisinopril and hydrochlorothiazide as soon as possible. Medications that directly affect the renin-angiotensin system can harm your developing fetus, potentially causing injury or even death. Angioedema, including swelling in the throat, can happen at any time while you are being treated with angiotensin converting enzyme inhibitors like lisinopril and hydrochlorothiazide. You should report any signs or symptoms of angioedema immediately, such as swelling of the face, extremities, eyes, lips, or tongue, and difficulty swallowing or breathing. Please do not take any more medication until you have spoken with your prescribing physician. Be cautious and report any feelings of lightheadedness, especially during the first few days of your therapy. If you experience actual fainting, please stop taking the medication and consult with your prescribing physician. Excessive sweating and dehydration can lead to a significant drop in blood pressure due to reduced fluid volume. Do not use salt substitutes that contain potassium without first consulting your physician. Promptly report any signs of infection, such as a sore throat or fever, as these may indicate leukopenia or neutropenia. If you are a female of childbearing age, it’s important to understand the risks of taking lisinopril and hydrochlorothiazide during pregnancy. Please inform your physician about any pregnancies as soon as possible. If you are taking hydrochlorothiazide, remember to protect your skin from the sun and schedule regular skin cancer screenings. If you are receiving both an ACE inhibitor and an mTOR inhibitor (like temsirolimus, sirolimus, or everolimus), you may have an increased risk of angioedema. If you are taking neprilysin inhibitors alongside your medication, be aware that this may also increase your risk for angioedema. Pregnancy & Lactation It is currently unclear if lisinopril is passed into human milk. You should consider whether to stop nursing and/or discontinue lisinopril and hydrochlorothiazide, keeping in mind how important the medication is for you. Side Effects You may experience dizziness (7.5%). You might have a headache (5.2%). Coughing (3.9%) could occur. Fatigue (3.7%) is also a possibility. You may notice orthostatic effects (3.2%). Diarrhea (2.5%) can happen. Nausea (2.2%) might be experienced. An upper respiratory infection (2.2%) could develop. Muscle cramps (2.0%) may occur. You might feel asthenia (1.8%). Paresthesia (1.5%) could be a symptom. Hypotension (1.4%) may happen. Vomiting (1.4%) is also a possibility. Dyspepsia (1.3%) might occur. You may develop a rash (1.2%). Impotence (1.2%) could be experienced. Chest pain is something to watch for. Abdominal pain may occur. Syncope could happen. You might feel chest discomfort. Fever is a possibility. Trauma may occur. You could experience a virus infection. Palpitations might happen. Orthostatic hypotension is something to be aware of. Gastrointestinal cramps may occur. You might have a dry mouth. Constipation could be a concern. Heartburn may happen. Back pain is something to consider. Shoulder pain might occur. Knee pain could be experienced. Back strain may happen. Myalgia might be a symptom. Foot pain could occur. You may notice a decreased libido. Vertigo is something to be aware of. Depression might occur. Somnolence could be experienced. You might catch a common cold. Nasal congestion may happen. Influenza is a possibility. Bronchitis could occur. Pharyngeal pain might be experienced. Dyspnea may happen. You could experience pulmonary congestion. Chronic sinusitis is something to consider. Allergic rhinitis might occur. Pharyngeal discomfort could happen. Flushing may be experienced. Pruritus might occur. Skin inflammation could happen. Diaphoresis may be a symptom. You might develop cutaneous pseudolymphoma. Blurred vision is something to watch for. Tinnitus could occur. Otaligia might be experienced. You may have a urinary tract infection. Anaphylactoid reactions are a possibility. Malaise might occur. Edema could happen. Facial edema may be experienced. Pain is something to be aware of. Pelvic pain might occur. Flank pain could happen. Chills may be experienced. Cardiac arrest is a serious concern. Myocardial infarction could occur. A cerebrovascular accident is something to watch for. Pulmonary embolism may happen. Infarction could occur. Worsening of heart failure is a possibility. Arrhythmias might be experienced. Angina pectoris could happen. Transient ischemic attacks may occur. You might experience paroxysmal nocturnal dyspnea. Decreased blood pressure is something to monitor. Peripheral edema may happen. Vasculitis could occur. Pancreatitis is a possibility. Hepatitis might be experienced. Gastritis could happen. Anorexia may occur. Flatulence might be a concern. Increased salivation could happen. Gout may be experienced. Weight loss is something to watch for. Dehydration could occur. Fluid overload may happen. Weight gain might be experienced. Arthritis is a possibility. Arthralgia could occur. Neck pain may happen. Hip pain might be experienced. Joint pain could occur. Leg pain may happen. Arm pain is something to consider. Lumbago might occur. Ataxia could be a symptom. Memory impairment may happen. Tremors might occur. Insomnia is something to be aware of. A stroke is a serious concern. Nervousness might be experienced. Confusion could happen. Peripheral neuropathy may occur. Spasms might be a symptom. Hypersomnia could happen. Irritability may be experienced. Mood alterations might occur. Hallucinations are a possibility. Malignant lung neoplasms could happen. Hemoptysis might be experienced. Pulmonary edema may occur. Pulmonary infiltrates could happen. Bronchospasm is something to watch for. Asthma might occur. Pleural effusion could happen. Pneumonia may be experienced. Eosinophilic pneumonitis might occur. Wheezing is something to be aware of. Orthopnea could happen. Painful respiration may occur. Epistaxis might be experienced. Laryngitis could happen. Sinusitis may occur. Pharyngitis might be a concern. Rhinitis could happen. Rhinorrhea may be experienced. Chest sound abnormalities might occur. Urticaria is something to watch for. Alopecia could happen. Herpes zoster may occur. Photosensitivity might be experienced. Skin lesions could happen. Skin infections may occur. Pemphigus might be a concern. Erythema could happen. Psoriasis may be experienced. Toxic epidermal necrolysis is a serious concern. Stevens-Johnson Syndrome might occur. Visual loss is something to monitor. Diplopia could happen. Photophobia may be experienced. Taste alteration might occur. Olfactory disturbance could happen. Acute renal failure is a serious concern. Oliguria might occur. Anuria could happen. Uremia may be experienced. Progressive azotemia might occur. Renal dysfunction is something to watch for. Pyelonephritis could happen. Dysuria may occur. Breast pain might be experienced. Acute transient myopia could happen. Acute angle-closure glaucoma is a serious concern. Fetal or neonatal jaundice may occur. Thrombocytopenia might be experienced. Warnings when pregnancy is detected, discontinue lisinopril and hydrochlorothiazide as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus angioedema, including laryngeal edema may occur at any time during treatment with angiotensin converting enzyme inhibitors, including lisinopril and hydrochlorothiazide patients should report immediately any signs or symptoms suggesting angioedema (swelling of face, extremities, eyes, lips, tongue, difficulty in swallowing or breathing) and to take no more drug until they have consulted with the prescribing physician patients should be cautioned to report lightheadedness especially during the first few days of therapy if actual syncope occurs, the patients should be told to discontinue the drug until they have consulted with the prescribing physician excessive perspiration and dehydration may lead to an excessive fall in blood pressure because of reduction in fluid volume patients should be told not to use salt substitutes containing potassium without consulting their physician patients should be told to report promptly any indication of infection (eg, sore throat, fever) which may be a sign of leukopenia/neutropenia female patients of childbearing age should be told about the consequences of exposure to lisinopril and hydrochlorothiazide during pregnancy patients should be asked to report pregnancies to their physicians as soon as possible instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening patients receiving coadministration of ACE inhibitor and mTOR inhibitor (e.g., temsirolimus, sirolimus, everolimus) therapy may be at increased risk for angioedema patients taking concomitant neprilysin inhibitors may be at increased risk for angioedema Pregnancy & Lactation it is not known whether lisinopril is excreted in human milk a decision should be made whether to discontinue nursing and/or discontinue lisinopril and hydrochlorothiazide, taking into account the importance of the drug to the mother Side Effects dizziness (7.5%) headache (5.2%) cough (3.9%) fatigue (3.7%) orthostatic effects (3.2%) diarrhea (2.5%) nausea (2.2%) upper respiratory infection (2.2%) muscle cramps (2.0%) asthenia (1.8%) paresthesia (1.5%) hypotension (1.4%) vomiting (1.4%) dyspepsia (1.3%) rash (1.2%) impotence (1.2%) chest pain abdominal pain syncope chest discomfort fever trauma virus infection palpitation orthostatic hypotension gastrointestinal cramps dry mouth constipation heartburn back pain shoulder pain knee pain back strain myalgia foot pain decreased libido vertigo depression somnolence common cold nasal congestion influenza bronchitis pharyngeal pain dyspnea pulmonary congestion chronic sinusitis allergic rhinitis pharyngeal discomfort flushing pruritus skin inflammation diaphoresis cutaneous pseudolymphoma blurred vision tinnitus otalgia urinary tract infection anaphylactoid reactions malaise edema facial edema pain pelvic pain flank pain chills cardiac arrest myocardial infarction cerebrovascular accident pulmonary embolism infarction worsening of heart failure arrhythmias angina pectoris transient ischemic attacks paroxysmal nocturnal dyspnea decreased blood pressure peripheral edema vasculitis pancreatitis hepatitis gastritis anorexia flatulence increased salivation gout weight loss dehydration fluid overload weight gain arthritis arthralgia neck pain hip pain joint pain leg pain arm pain lumbago ataxia memory impairment tremor insomnia stroke nervousness confusion peripheral neuropathy spasm hypersomnia irritability mood alterations hallucinations malignant lung neoplasms hemoptysis pulmonary edema pulmonary infiltrates bronchospasm asthma pleural effusion pneumonia eosinophilic pneumonitis wheezing orthopnea painful respiration epistaxis laryngitis sinusitis pharyngitis rhinitis rhinorrhea chest sound abnormalities urticaria alopecia herpes zoster photosensitivity skin lesions skin infections pemphigus erythema psoriasis toxic epidermal necrolysis Stevens-Johnson Syndrome visual loss diplopia photophobia taste alteration olfactory disturbance acute renal failure oliguria anuria uremia progressive azotemia renal dysfunction pyelonephritis dysuria breast pain acute transient myopia acute angle-closure glaucoma fetal or neonatal jaundice thrombocytopenia
Lisinopril and Hydrochlorothiazide Rx tablet REMEDYREPACK INC.	Popularity – score 0 out of 100 (least-viewed drug)	12 warnings	2 pregnancy and lactation warnings	64 side effects	Trend: rose 46% over 11 months.
Lisinopril and Hydrochlorothiazide® · First marketed 2017 · Label last revised January 8, 2026View full label details → Warnings If you find out you are pregnant, please stop taking lisinopril and hydrochlorothiazide as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially causing injury or even death. Angioedema, including swelling of the larynx, can occur at any time while you are being treated with angiotensin converting enzyme inhibitors, such as lisinopril and hydrochlorothiazide. You should report any signs or symptoms of angioedema immediately, such as swelling of the face, extremities, eyes, lips, or tongue, and difficulty swallowing or breathing. Please do not take any more medication until you have consulted with your prescribing physician. Be cautious and report any feelings of lightheadedness, especially during the first few days of your therapy. If you experience actual fainting, please stop taking the medication and consult with your prescribing physician. Excessive sweating and dehydration can lead to a significant drop in blood pressure due to reduced fluid volume. Do not use salt substitutes that contain potassium without first consulting your physician. Promptly report any signs of infection, such as a sore throat or fever, as these may indicate leukopenia or neutropenia. If you are a female of childbearing age, it’s important to understand the risks of taking lisinopril and hydrochlorothiazide during pregnancy. Please inform your physician about any pregnancies as soon as possible. If you are taking hydrochlorothiazide, remember to protect your skin from the sun and schedule regular skin cancer screenings. Pregnancy & Lactation It is not known if lisinopril is passed into human milk. You should consider whether to stop nursing and/or discontinue lisinopril and hydrochlorothiazide, keeping in mind how important the medication is for you. Side Effects You may experience dizziness (7.5%). You might have a headache (5.2%). Coughing (3.9%) could occur. Fatigue (3.7%) is also a possibility. You may notice orthostatic effects (3.2%). Diarrhea (2.5%) can happen. Nausea (2.2%) might be experienced. An upper respiratory infection (2.2%) could develop. Muscle cramps (2.0%) may occur. You might feel asthenia (1.8%). Paresthesia (1.5%) could be a symptom. Hypotension (1.4%) is a potential side effect. Vomiting (1.4%) may happen. Dyspepsia (1.3%) could occur. You might develop a rash (1.2%). Impotence (1.2%) is a possibility. Chest pain may occur. You might experience abdominal pain. Syncope could happen. Chest discomfort may be felt. Fever is a potential side effect. Trauma may occur. You could have a virus infection. Palpitations might be experienced. Orthostatic hypotension is a possibility. Gastrointestinal cramps may occur. You might experience dry mouth. Constipation could happen. Heartburn may be felt. Back pain is a potential side effect. Shoulder pain might occur. Knee pain could be experienced. Back strain may happen. Myalgia might occur. Foot pain is a possibility. Decreased libido could be experienced. You may feel vertigo. Depression is a potential side effect. Somnolence might occur. You could catch a common cold. Nasal congestion may happen. Influenza is a possibility. Bronchitis might occur. You may experience pharyngeal pain. Dyspnea could happen. Pulmonary congestion may occur. Chronic sinusitis is a potential side effect. Allergic rhinitis might be experienced. You may feel pharyngeal discomfort. Flushing could occur. Pruritus might happen. Skin inflammation is a possibility. Diaphoresis may occur. You might develop cutaneous pseudolymphoma. Blurred vision could happen. Tinnitus may be experienced. Otaligia might occur. You could have a urinary tract infection. Angioedema of the face, extremities, lips, tongue, glottis and/or larynx may occur. Intestinal angioedema is a possibility. Syncope (0.8%) could happen. Hypotension (1.4%) is a potential side effect. Orthostatic hypotension (0.5%) may occur. Other orthostatic effects (3.2%) could happen. Warnings when pregnancy is detected, discontinue lisinopril and hydrochlorothiazide as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus angioedema, including laryngeal edema may occur at any time during treatment with angiotensin converting enzyme inhibitors, including lisinopril and hydrochlorothiazide patients should be advised to report immediately any signs or symptoms suggesting angioedema (swelling of face, extremities, eyes, lips, tongue, difficulty in swallowing or breathing) and to take no more drug until they have consulted with the prescribing physician patients should be cautioned to report lightheadedness especially during the first few days of therapy if actual syncope occurs, the patients should be told to discontinue the drug until they have consulted with the prescribing physician excessive perspiration and dehydration may lead to an excessive fall in blood pressure because of reduction in fluid volume patients should be told not to use salt substitutes containing potassium without consulting their physician patients should be told to report promptly any indication of infection (eg, sore throat, fever) which may be a sign of leukopenia/neutropenia female patients of childbearing age should be told about the consequences of exposure to lisinopril and hydrochlorothiazide during pregnancy patients should be asked to report pregnancies to their physicians as soon as possible instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening Pregnancy & Lactation it is not known whether lisinopril is excreted in human milk a decision should be made whether to discontinue nursing and/or discontinue lisinopril and hydrochlorothiazide, taking into account the importance of the drug to the mother Side Effects dizziness (7.5%) headache (5.2%) cough (3.9%) fatigue (3.7%) orthostatic effects (3.2%) diarrhea (2.5%) nausea (2.2%) upper respiratory infection (2.2%) muscle cramps (2.0%) asthenia (1.8%) paresthesia (1.5%) hypotension (1.4%) vomiting (1.4%) dyspepsia (1.3%) rash (1.2%) impotence (1.2%) chest pain abdominal pain syncope chest discomfort fever trauma virus infection palpitation orthostatic hypotension gastrointestinal cramps dry mouth constipation heartburn back pain shoulder pain knee pain back strain myalgia foot pain decreased libido vertigo depression somnolence common cold nasal congestion influenza bronchitis pharyngeal pain dyspnea pulmonary congestion chronic sinusitis allergic rhinitis pharyngeal discomfort flushing pruritus skin inflammation diaphoresis cutaneous pseudolymphoma blurred vision tinnitus otalgia urinary tract infection angioedema of the face, extremities, lips, tongue, glottis and/or larynx intestinal angioedema syncope (0.8%) hypotension (1.4%) orthostatic hypotension (0.5%) other orthostatic effects (3.2%)
Lisinopril and Hydrochlorothiazide Rx tablet Lupin Pharmaceuticals, Inc.	Popularity – score 0 out of 100 (least-viewed drug)	16 warnings	2 pregnancy and lactation warnings	159 side effects	Trend: rose 46% over 11 months.
Lisinopril and Hydrochlorothiazide® · First marketed 2006 · Label last revised November 24, 2025View full label details → Warnings If you find out you are pregnant, please stop taking lisinopril and hydrochlorothiazide as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. Angioedema, including swelling of the larynx, can occur at any time while you are being treated with angiotensin converting enzyme inhibitors, such as lisinopril and hydrochlorothiazide. You should report any signs or symptoms of angioedema immediately, such as swelling of the face, extremities, eyes, lips, or tongue, and difficulty swallowing or breathing. Please do not take any more medication until you have consulted with your prescribing physician. Be cautious and report any feelings of lightheadedness, especially during the first few days of your therapy. If you experience actual fainting, please stop taking the medication and consult with your prescribing physician. Do not use salt substitutes that contain potassium without first checking with your physician. Promptly report any signs of infection, such as a sore throat or fever, as these may indicate leukopenia or neutropenia. If you are a female of childbearing age, it’s important to understand the risks of taking lisinopril and hydrochlorothiazide during pregnancy. Please inform your physician about any pregnancies as soon as possible. If you are taking hydrochlorothiazide, remember to protect your skin from the sun and schedule regular skin cancer screenings. If you are on diuretics, especially if you have recently started this therapy, you may occasionally experience a significant drop in blood pressure after starting lisinopril. If you experience low blood pressure, you should lie down and, if necessary, receive an intravenous infusion of normal saline. If you are receiving both an ACE inhibitor and an mTOR inhibitor (like temsirolimus, sirolimus, or everolimus), be aware that you may be at a higher risk for angioedema. If you are taking neprilysin inhibitors alongside your treatment, you may also be at increased risk for angioedema. Your healthcare provider should closely monitor you to ensure that you are achieving the desired effects from lisinopril and hydrochlorothiazide. Pregnancy & Lactation It is not known if lisinopril is passed into human milk. You should consider whether to stop nursing and/or discontinue lisinopril and hydrochlorothiazide, keeping in mind how important the medication is for you. Side Effects You may experience dizziness (7.5%). You might have a headache (5.2%). Coughing (3.9%) can occur. Fatigue (3.7%) is another possible effect. You could notice orthostatic effects (3.2%). Diarrhea (2.5%) may happen. Nausea (2.2%) is also a possibility. You might get an upper respiratory infection (2.2%). Muscle cramps (2.0%) can occur. You may feel asthenia (1.8%). Paresthesia (1.5%) might be experienced. Hypotension (1.4%) is a potential side effect. Vomiting (1.4%) can happen. Dyspepsia (1.3%) may occur. You might develop a rash (1.2%). Impotence (1.2%) is also a possibility. Chest pain can occur. You may experience abdominal pain. Syncope might happen. Chest discomfort can occur. Fever may be experienced. Trauma can happen. You might contract a virus infection. Palpitations may occur. Orthostatic hypotension is a possibility. Gastrointestinal cramps can happen. You may experience dry mouth. Constipation might occur. Heartburn can happen. You might feel back pain. Shoulder pain may occur. Knee pain can happen. Back strain might be experienced. Myalgia can occur. You may feel foot pain. Decreased libido is a possibility. You might experience vertigo. Depression may occur. Somnolence can happen. You might catch a common cold. Nasal congestion may occur. Influenza can happen. Bronchitis might be experienced. You may feel pharyngeal pain. Dyspnea can occur. Pulmonary congestion might happen. Chronic sinusitis may occur. You might experience allergic rhinitis. Pharyngeal discomfort can happen. Flushing may occur. You might experience pruritus. Skin inflammation can happen. Diaphoresis may occur. You might develop cutaneous pseudolymphoma. Blurred vision can occur. Tinnitus may happen. You might feel otalgia. A urinary tract infection can occur. Anaphylactoid reactions may happen. You might feel malaise. Edema can occur. Facial edema may happen. You might experience pain. Pelvic pain can occur. Flank pain may happen. Chills can occur. Cardiac arrest is a serious possibility. Myocardial infarction may occur. A cerebrovascular accident can happen. Pulmonary embolism is a serious concern. Infarction may occur. Worsening of heart failure can happen. Arrhythmias may occur. You might experience angina pectoris. Transient ischemic attacks can happen. Paroxysmal nocturnal dyspnea may occur. Decreased blood pressure is a possibility. Peripheral edema might happen. Vasculitis can occur. Pancreatitis may happen. Hepatitis is a possibility. Gastritis might occur. You may experience anorexia. Flatulence can happen. Increased salivation may occur. Gout might be experienced. Weight loss can occur. Dehydration is a possibility. Fluid overload may happen. Weight gain can occur. Arthritis might be experienced. You may feel arthralgia. Neck pain can happen. Hip pain may occur. Joint pain might be experienced. Leg pain can occur. Arm pain may happen. Lumbago might be experienced. Ataxia can occur. You might experience memory impairment. Tremors may happen. Insomnia can occur. A stroke is a serious concern. Nervousness may occur. Confusion can happen. You might experience peripheral neuropathy. Spasms may occur. Hypersomnia can happen. Irritability might be experienced. Mood alterations may occur. Hallucinations can happen. Malignant lung neoplasms are a serious concern. Hemoptysis may occur. Pulmonary edema can happen. Pulmonary infiltrates might be experienced. Bronchospasm may occur. Asthma can happen. Pleural effusion might be experienced. Pneumonia may occur. Eosinophilic pneumonitis can happen. Wheezing might be experienced. Orthopnea may occur. You might experience painful respiration. Epistaxis can happen. Laryngitis may occur. Sinusitis can happen. Pharyngitis might be experienced. Rhinitis may occur. Rhinorrhea can happen. Chest sound abnormalities might be experienced. Urticaria may occur. Alopecia can happen. Herpes zoster might be experienced. Photosensitivity may occur. You might develop skin lesions. Skin infections can happen. Pemphigus may occur. Erythema can happen. Psoriasis might be experienced. Toxic epidermal necrolysis is a serious concern. Stevens-Johnson Syndrome may occur. You might experience visual loss. Diplopia can happen. Photophobia may occur. Taste alteration might be experienced. Olfactory disturbance can happen. Acute renal failure is a serious concern. Oliguria may occur. Anuria can happen. Uremia might be experienced. Progressive azotemia may occur. Renal dysfunction can happen. Pyelonephritis may occur. Dysuria can happen. You might experience breast pain. Acute myopia may occur. Secondary angle-closure glaucoma is a serious concern. Fetal or neonatal jaundice may occur. Thrombocytopenia can happen. Warnings when pregnancy is detected, discontinue lisinopril and hydrochlorothiazide as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus angioedema, including laryngeal edema may occur at any time during treatment with angiotensin converting enzyme inhibitors, including lisinopril and hydrochlorothiazide patients should report immediately any signs or symptoms suggesting angioedema (swelling of face, extremities, eyes, lips, tongue, difficulty in swallowing or breathing) and to take no more drug until they have consulted with the prescribing physician patients should be cautioned to report lightheadedness especially during the first few days of therapy if actual syncope occurs, the patients should be told to discontinue the drug until they have consulted with the prescribing physician patients should be told not to use salt substitutes containing potassium without consulting their physician patients should be told to report promptly any indication of infection (eg, sore throat, fever) which may be a sign of leukopenia/neutropenia female patients of childbearing age should be told about the consequences of exposure to lisinopril and hydrochlorothiazide during pregnancy patients should be asked to report pregnancies to their physicians as soon as possible instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening patients on diuretics, and especially those in whom diuretic therapy was recently instituted, may occasionally experience an excessive reduction of blood pressure after initiation of therapy with lisinopril if hypotension occurs, the patient should be placed in the supine position and, if necessary, receive an intravenous infusion of normal saline patients receiving coadministration of ACE inhibitor and mTOR inhibitor (e.g., temsirolimus, sirolimus, everolimus) therapy may be at increased risk for angioedema patients taking concomitant neprilysin inhibitors may be at increased risk for angioedema patients should be observed closely to determine if the desired effect of lisinopril and hydrochlorothiazide is obtained Pregnancy & Lactation it is not known whether lisinopril is excreted in human milk a decision should be made whether to discontinue nursing and/or discontinue lisinopril and hydrochlorothiazide, taking into account the importance of the drug to the mother Side Effects dizziness (7.5%) headache (5.2%) cough (3.9%) fatigue (3.7%) orthostatic effects (3.2%) diarrhea (2.5%) nausea (2.2%) upper respiratory infection (2.2%) muscle cramps (2.0%) asthenia (1.8%) paresthesia (1.5%) hypotension (1.4%) vomiting (1.4%) dyspepsia (1.3%) rash (1.2%) impotence (1.2%) chest pain abdominal pain syncope chest discomfort fever trauma virus infection palpitation orthostatic hypotension gastrointestinal cramps dry mouth constipation heartburn back pain shoulder pain knee pain back strain myalgia foot pain decreased libido vertigo depression somnolence common cold nasal congestion influenza bronchitis pharyngeal pain dyspnea pulmonary congestion chronic sinusitis allergic rhinitis pharyngeal discomfort flushing pruritus skin inflammation diaphoresis cutaneous pseudolymphoma blurred vision tinnitus otalgia urinary tract infection anaphylactoid reactions malaise edema facial edema pain pelvic pain flank pain chills cardiac arrest myocardial infarction cerebrovascular accident pulmonary embolism infarction worsening of heart failure arrhythmias angina pectoris transient ischemic attacks paroxysmal nocturnal dyspnea decreased blood pressure peripheral edema vasculitis pancreatitis hepatitis gastritis anorexia flatulence increased salivation gout weight loss dehydration fluid overload weight gain arthritis arthralgia neck pain hip pain joint pain leg pain arm pain lumbago ataxia memory impairment tremor insomnia stroke nervousness confusion peripheral neuropathy spasm hypersomnia irritability mood alterations hallucinations malignant lung neoplasms hemoptysis pulmonary edema pulmonary infiltrates bronchospasm asthma pleural effusion pneumonia eosinophilic pneumonitis wheezing orthopnea painful respiration epistaxis laryngitis sinusitis pharyngitis rhinitis rhinorrhea chest sound abnormalities urticaria alopecia herpes zoster photosensitivity skin lesions skin infections pemphigus erythema psoriasis toxic epidermal necrolysis Stevens-Johnson Syndrome visual loss diplopia photophobia taste alteration olfactory disturbance acute renal failure oliguria anuria uremia progressive azotemia renal dysfunction pyelonephritis dysuria breast pain acute myopia secondary angle-closure glaucoma fetal or neonatal jaundice thrombocytopenia
Lisinopril and Hydrochlorothiazide Rx tablet Legacy Pharmaceutical Packaging, LLC	Popularity – score 0 out of 100 (least-viewed drug)	25 warnings	2 pregnancy and lactation warnings	67 side effects	Trend: rose 46% over 11 months.
Lisinopril and Hydrochlorothiazide® · First marketed 2006 · Label last revised April 17, 2025View full label details → Warnings If you find out you are pregnant, please stop taking lisinopril and hydrochlorothiazide as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. Angioedema affecting the face, extremities, lips, tongue, glottis, and/or larynx has been reported in patients treated with angiotensin-converting enzyme inhibitors, including lisinopril. You should promptly discontinue lisinopril and hydrochlorothiazide, and your healthcare provider will ensure you receive the appropriate therapy and monitoring until all signs and symptoms have completely resolved. You may need to be observed for a longer period, as treatment with antihistamines and corticosteroids might not be enough. If you have swelling of the tongue, glottis, or larynx, you may be at risk for airway obstruction, especially if you have a history of airway surgery. If there is swelling of the tongue, glottis, or larynx that could cause airway obstruction, your healthcare provider should promptly provide subcutaneous epinephrine solution 1:1000 (0.3 mL to 0.5 mL) and take necessary measures to ensure your airway remains open. Intestinal angioedema has been reported in patients treated with ACE inhibitors. If you have a history of angioedema not related to ACE-inhibitor therapy, you may be at a higher risk of experiencing angioedema while taking an ACE inhibitor. Two patients receiving desensitizing treatment with hymenoptera venom while on ACE inhibitors experienced life-threatening anaphylactoid reactions. Some patients undergoing dialysis with high-flux membranes and treated with an ACE inhibitor have reported sudden and potentially life-threatening anaphylactoid reactions. While excessive hypotension is rarely seen in uncomplicated hypertensive patients, it can occur with lisinopril use in individuals who are salt or volume depleted. Syncope has been reported in 0.8 percent of patients taking lisinopril and hydrochlorothiazide. In patients with severe congestive heart failure, excessive hypotension has been observed and may be linked to oliguria and/or progressive azotemia, and in rare cases, acute renal failure and/or death. If you experience hypotension, you should lie down and, if necessary, receive an intravenous infusion of normal saline. Your healthcare provider may consider periodic monitoring of white blood cell counts if you have collagen vascular disease or renal disease. If you develop jaundice or significant elevations in hepatic enzymes while taking ACE inhibitors, you should stop the medication and seek appropriate medical follow-up. You should report any signs or symptoms of angioedema immediately, such as swelling of the face, extremities, eyes, lips, tongue, or difficulty swallowing or breathing, and refrain from taking any more medication until you consult with your prescribing physician. Please be cautious and report any feelings of lightheadedness, especially during the first few days of therapy. If you experience actual syncope, you should stop taking the medication until you have consulted with your prescribing physician. Do not use salt substitutes containing potassium without first consulting your physician. You should promptly report any signs of infection, such as a sore throat or fever, as these may indicate leukopenia or neutropenia. If you are a female of childbearing age, it’s important to understand the potential consequences of exposure to lisinopril and hydrochlorothiazide during pregnancy. Please inform your physician about any pregnancies as soon as possible. If you are taking hydrochlorothiazide, remember to protect your skin from the sun and schedule regular skin cancer screenings. Pregnancy & Lactation It is not known if lisinopril is passed into human milk. You should consider whether to stop nursing and/or to discontinue lisinopril and hydrochlorothiazide, keeping in mind how important the medication is for you. Side Effects You may experience dizziness (7.5%). You might have a headache (5.2%). A cough (3.9%) could occur. You may feel fatigue (3.7%). Watch for orthostatic effects (3.2%). You might experience diarrhea (2.5%). You may feel nausea (2.2%). An upper respiratory infection (2.2%) could happen. You might have muscle cramps (2.0%). You may feel asthenia (1.8%). You might notice paresthesia (1.5%). Be aware of hypotension (1.4%). You may experience vomiting (1.4%). You might have dyspepsia (1.3%). You may develop a rash (1.2%). You might experience impotence (1.2%). You could feel chest pain. You may have abdominal pain. Be cautious of syncope. You might feel chest discomfort. You may experience a fever. You could have trauma. You might catch a virus infection. You may notice palpitation. Watch for orthostatic hypotension. You might experience gastrointestinal cramps. You may have a dry mouth. You could experience constipation. You might feel heartburn. You may have back pain. You might experience shoulder pain. You may feel knee pain. You could have a back strain. You might experience myalgia. You may feel foot pain. You might notice a decreased libido. You may experience vertigo. You could feel depression. You might experience somnolence. You may catch a common cold. You might have nasal congestion. You may experience influenza. You could develop bronchitis. You might feel pharyngeal pain. You may experience dyspnea. You could have pulmonary congestion. You might experience chronic sinusitis. You may have allergic rhinitis. You might feel pharyngeal discomfort. You may experience flushing. You could have pruritus. You might notice skin inflammation. You may experience diaphoresis. You could develop cutaneous pseudolymphoma. You might have blurred vision. You may experience tinnitus. You could feel otalgia. You might develop a urinary tract infection. Be aware of angioedema of the face. You may experience angioedema of the extremities. You might notice angioedema of the lips. You may have angioedema of the tongue. You could experience angioedema of the glottis. You might have angioedema of the larynx. You may experience intestinal angioedema. You might experience syncope (0.8%). Watch for other orthostatic effects (3.2%). Warnings when pregnancy is detected, discontinue lisinopril and hydrochlorothiazide as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus angioedema of the face, extremities, lips, tongue, glottis and/or larynx has been reported in patients treated with angiotensin-converting enzyme inhibitors, including lisinopril lisinopril and hydrochlorothiazide should be promptly discontinued and the appropriate therapy and monitoring should be provided until complete and sustained resolution of signs and symptoms has occurred patients may require prolonged observation since treatment with antihistamines and corticosteroids may not be sufficient patients with involvement of the tongue, glottis or larynx are likely to experience airway obstruction, especially those with a history of airway surgery where there is involvement of the tongue, glottis or larynx, likely to cause airway obstruction, subcutaneous epinephrine solution 1:1000 (0.3 mL to 0.5 mL) and/or measures necessary to ensure a patent airway, should be promptly provided intestinal angioedema has been reported in patients treated with ACE inhibitors patients with a history of angioedema unrelated to ACE-inhibitor therapy may be at increased risk of angioedema while receiving an ACE inhibitor two patients undergoing desensitizing treatment with hymenoptera venom while receiving ACE inhibitors sustained life-threatening anaphylactoid reactions sudden and potentially life-threatening anaphylactoid reactions have been reported in some patients dialyzed with high-flux membranes and treated concomitantly with an ACE inhibitor excessive hypotension was rarely seen in uncomplicated hypertensive patients but is a possible consequence of lisinopril use in salt/volume-depleted persons syncope has been reported in 0.8 percent of patients receiving lisinopril and hydrochlorothiazide in patients with severe congestive heart failure, excessive hypotension has been observed and may be associated with oliguria and/or progressive azotemia, and rarely with acute renal failure and/or death if hypotension occurs, the patient should be placed in the supine position and, if necessary, receive an intravenous infusion of normal saline periodic monitoring of white blood cell counts in patients with collagen vascular disease and renal disease should be considered patients receiving ACE inhibitors who develop jaundice or marked elevations of hepatic enzymes should discontinue the ACE inhibitor and receive appropriate medical follow-up patients should be advised to report immediately any signs or symptoms suggesting angioedema (swelling of face, extremities, eyes, lips, tongue, difficulty in swallowing or breathing) and to take no more drug until they have consulted with the prescribing physician patients should be cautioned to report lightheadedness especially during the first few days of therapy if actual syncope occurs, the patients should be told to discontinue the drug until they have consulted with the prescribing physician patients should be told not to use salt substitutes containing potassium without consulting their physician patients should be told to report promptly any indication of infection (eg, sore throat, fever) which may be a sign of leukopenia/neutropenia female patients of childbearing age should be told about the consequences of exposure to lisinopril and hydrochlorothiazide during pregnancy patients should be asked to report pregnancies to their physicians as soon as possible instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening Pregnancy & Lactation it is not known whether lisinopril is excreted in human milk a decision should be made whether to discontinue nursing and/or to discontinue lisinopril and hydrochlorothiazide, taking into account the importance of the drug to the mother Side Effects dizziness (7.5%) headache (5.2%) cough (3.9%) fatigue (3.7%) orthostatic effects (3.2%) diarrhea (2.5%) nausea (2.2%) upper respiratory infection (2.2%) muscle cramps (2.0%) asthenia (1.8%) paresthesia (1.5%) hypotension (1.4%) vomiting (1.4%) dyspepsia (1.3%) rash (1.2%) impotence (1.2%) chest pain abdominal pain syncope chest discomfort fever trauma virus infection palpitation orthostatic hypotension gastrointestinal cramps dry mouth constipation heartburn back pain shoulder pain knee pain back strain myalgia foot pain decreased libido vertigo depression somnolence common cold nasal congestion influenza bronchitis pharyngeal pain dyspnea pulmonary congestion chronic sinusitis allergic rhinitis pharyngeal discomfort flushing pruritus skin inflammation diaphoresis cutaneous pseudolymphoma blurred vision tinnitus otalgia urinary tract infection angioedema of the face angioedema of the extremities angioedema of the lips angioedema of the tongue angioedema of the glottis angioedema of the larynx intestinal angioedema syncope (0.8%) other orthostatic effects (3.2%)
Lisinopril and Hydrochlorothiazide Rx tablet REMEDYREPACK INC.	Popularity – score 0 out of 100 (least-viewed drug)	12 warnings	2 pregnancy and lactation warnings	165 side effects	Trend: rose 46% over 11 months.
Lisinopril and Hydrochlorothiazide® · First marketed 2017 · Label last revised January 8, 2026View full label details → Warnings If you find out you are pregnant, please stop taking lisinopril and hydrochlorothiazide as soon as possible. Medications that directly affect the renin-angiotensin system can harm your developing fetus, potentially leading to serious injury or death. Angioedema, including swelling of the throat, can happen at any time while you are being treated with angiotensin converting enzyme inhibitors like lisinopril and hydrochlorothiazide. You should report any signs or symptoms of angioedema right away, such as swelling of your face, extremities, eyes, lips, or tongue, or any difficulty swallowing or breathing. Please do not take any more medication until you have spoken with your prescribing physician. Be cautious and let your healthcare provider know if you experience lightheadedness, especially during the first few days of your treatment. If you experience fainting, please stop taking the medication and consult with your prescribing physician. Excessive sweating and dehydration can lead to a significant drop in blood pressure due to reduced fluid volume. Do not use salt substitutes that contain potassium without first checking with your physician. Promptly report any signs of infection, such as a sore throat or fever, as these may indicate leukopenia or neutropenia. If you are a female of childbearing age, it’s important to understand the risks of taking lisinopril and hydrochlorothiazide during pregnancy. Please inform your physician about any pregnancies as soon as possible. If you are taking hydrochlorothiazide, remember to protect your skin from the sun and schedule regular skin cancer screenings. Pregnancy & Lactation It is not known if lisinopril is passed into human milk. You should consider whether to stop nursing and/or discontinue lisinopril and hydrochlorothiazide, keeping in mind how important the medication is for you. Side Effects You may experience dizziness (7.5%). You might have a headache (5.2%). A cough (3.9%) could occur. You may feel fatigue (3.7%). Watch for orthostatic effects (3.2%). You might experience diarrhea (2.5%). You may feel nausea (2.2%). An upper respiratory infection (2.2%) could happen. You might have muscle cramps (2.0%). You may feel asthenia (1.8%). You might notice paresthesia (1.5%). Be aware of hypotension (1.4%). You may experience vomiting (1.4%). You might have dyspepsia (1.3%). You may notice a rash (1.2%). You might experience impotence (1.2%). You could feel chest pain. You may have abdominal pain. Watch for syncope. You might feel chest discomfort. You may experience a fever. Be cautious of trauma. You could have a virus infection. You might notice palpitations. Be aware of orthostatic hypotension. You may experience gastrointestinal cramps. You might have a dry mouth. You may experience constipation. You might feel heartburn. You could have back pain. You may experience shoulder pain. You might feel knee pain. You could have a back strain. You may experience myalgia. You might feel foot pain. You may notice decreased libido. You could experience vertigo. You might feel depression. You may experience somnolence. You could catch a common cold. You might have nasal congestion. You may experience influenza. You could have bronchitis. You might feel pharyngeal pain. You may experience dyspnea. You could have pulmonary congestion. You might have chronic sinusitis. You may experience allergic rhinitis. You might feel pharyngeal discomfort. You could experience flushing. You may notice pruritus. You might have skin inflammation. You may experience diaphoresis. You could have cutaneous pseudolymphoma. You might notice blurred vision. You may experience tinnitus. You could have otalgia. You might develop a urinary tract infection. Be aware of angioedema of the face. You may experience angioedema of the extremities. You might notice angioedema of the lips. You could have angioedema of the tongue. You may experience angioedema of the glottis. You might have angioedema of the larynx. You could experience intestinal angioedema. You may notice chest sound abnormalities. Be aware of malignant lung neoplasms. You might experience hemoptysis. You may have pulmonary edema. You could have pulmonary infiltrates. You might experience bronchospasm. You may have asthma. You could experience pleural effusion. You might develop pneumonia. You may experience eosinophilic pneumonitis. You could have wheezing. You might experience orthopnea. You may feel painful respiration. You could have epistaxis. You might experience laryngitis. You may have sinusitis. You could develop pharyngitis. You might experience rhinitis. You may have rhinorrhea. You could feel weakness. Be aware of anaphylactoid reactions. You might feel malaise. You may notice edema. You could have facial edema. You might experience pain. You may have pelvic pain. You could feel flank pain. You might experience chills. Be cautious of cardiac arrest. You may have a myocardial infarction. Be aware of a potential cerebrovascular accident. You might experience a pulmonary embolism. You may have infarction. Be cautious of worsening of heart failure. You might experience arrhythmias. You may feel angina pectoris. Be aware of transient ischemic attacks. You might experience paroxysmal nocturnal dyspnea. You may notice decreased blood pressure. You could have peripheral edema. Be aware of vasculitis. You might experience pancreatitis. You may have hepatitis. You could develop gastritis. You might experience anorexia. You may have flatulence. You could notice increased salivation. You might develop gout. You may experience weight loss. Be cautious of dehydration. You might experience fluid overload. You may notice weight gain. You could have arthritis. You might experience arthralgia. You may feel neck pain. You could have hip pain. You might experience joint pain. You may feel leg pain. You could have arm pain. You might experience lumbago. You may have ataxia. You could notice memory impairment. You might experience a tremor. You may have insomnia. Be aware of a potential stroke. You might feel nervousness. You may experience confusion. You could have peripheral neuropathy. You might experience spasms. You may have hypersomnia. You could feel irritable. You might notice mood alterations. Be aware of potential hallucinations. You may experience urticaria. You might notice alopecia. You could have herpes zoster. Be cautious of photosensitivity. You might develop skin lesions. You may have skin infections. You could experience pemphigus. You might notice erythema. You may have psoriasis. You could experience visual loss. You might have diplopia. You may experience photophobia. You could notice a taste alteration. You might have an olfactory disturbance. Be aware of acute renal failure. You may experience oliguria. You could have anuria. You might experience uremia. Be cautious of progressive azotemia. You may have renal dysfunction. You could develop pyelonephritis. You might experience dysuria. You may feel breast pain. You could have acute myopia. Be aware of secondary angle-closure glaucoma. You might notice fetal or neonatal jaundice. You may experience thrombocytopenia. Warnings when pregnancy is detected, discontinue lisinopril and hydrochlorothiazide as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus angioedema, including laryngeal edema may occur at any time during treatment with angiotensin converting enzyme inhibitors, including lisinopril and hydrochlorothiazide patients should report immediately any signs or symptoms suggesting angioedema (swelling of face, extremities, eyes, lips, tongue, difficulty in swallowing or breathing) and to take no more drug until they have consulted with the prescribing physician patients should be cautioned to report lightheadedness especially during the first few days of therapy if actual syncope occurs, the patients should be told to discontinue the drug until they have consulted with the prescribing physician excessive perspiration and dehydration may lead to an excessive fall in blood pressure because of reduction in fluid volume patients should be told not to use salt substitutes containing potassium without consulting their physician patients should be told to report promptly any indication of infection (eg, sore throat, fever) which may be a sign of leukopenia/neutropenia female patients of childbearing age should be told about the consequences of exposure to lisinopril and hydrochlorothiazide during pregnancy patients should be asked to report pregnancies to their physicians as soon as possible instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening Pregnancy & Lactation it is not known whether lisinopril is excreted in human milk a decision should be made whether to discontinue nursing and/or discontinue lisinopril and hydrochlorothiazide, taking into account the importance of the drug to the mother Side Effects dizziness (7.5%) headache (5.2%) cough (3.9%) fatigue (3.7%) orthostatic effects (3.2%) diarrhea (2.5%) nausea (2.2%) upper respiratory infection (2.2%) muscle cramps (2.0%) asthenia (1.8%) paresthesia (1.5%) hypotension (1.4%) vomiting (1.4%) dyspepsia (1.3%) rash (1.2%) impotence (1.2%) chest pain abdominal pain syncope chest discomfort fever trauma virus infection palpitation orthostatic hypotension gastrointestinal cramps dry mouth constipation heartburn back pain shoulder pain knee pain back strain myalgia foot pain decreased libido vertigo depression somnolence common cold nasal congestion influenza bronchitis pharyngeal pain dyspnea pulmonary congestion chronic sinusitis allergic rhinitis pharyngeal discomfort flushing pruritus skin inflammation diaphoresis cutaneous pseudolymphoma blurred vision tinnitus otalgia urinary tract infection angioedema of the face angioedema of the extremities angioedema of the lips angioedema of the tongue angioedema of the glottis angioedema of the larynx intestinal angioedema chest sound abnormalities malignant lung neoplasms hemoptysis pulmonary edema pulmonary infiltrates bronchospasm asthma pleural effusion pneumonia eosinophilic pneumonitis wheezing orthopnea painful respiration epistaxis laryngitis sinusitis pharyngitis rhinitis rhinorrhea weakness anaphylactoid reactions malaise edema facial edema pain pelvic pain flank pain chills cardiac arrest myocardial infarction cerebrovascular accident pulmonary embolism infarction worsening of heart failure arrhythmias angina pectoris transient ischemic attacks paroxysmal nocturnal dyspnea decreased blood pressure peripheral edema vasculitis pancreatitis hepatitis gastritis anorexia flatulence increased salivation gout weight loss dehydration fluid overload weight gain arthritis arthralgia neck pain hip pain joint pain leg pain arm pain lumbago ataxia memory impairment tremor insomnia stroke nervousness confusion peripheral neuropathy spasm hypersomnia irritability mood alterations hallucinations urticaria alopecia herpes zoster photosensitivity skin lesions skin infections pemphigus erythema psoriasis visual loss diplopia photophobia taste alteration olfactory disturbance acute renal failure oliguria anuria uremia progressive azotemia renal dysfunction pyelonephritis dysuria breast pain acute myopia secondary angle-closure glaucoma fetal or neonatal jaundice thrombocytopenia
Lisinopril and Hydrochlorothiazide Rx tablet Actavis Pharma, Inc.	Popularity – score 0 out of 100 (least-viewed drug)	12 warnings	3 pregnancy and lactation warnings	168 side effects	Trend: rose 46% over 11 months.
Lisinopril and Hydrochlorothiazide® · First marketed 2002 · Label last revised May 1, 2020View full label details → Warnings If you find out you are pregnant, please stop taking Lisinopril and Hydrochlorothiazide Tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially causing injury or even death. Angioedema, including swelling of the larynx, can happen at any time while you are being treated with angiotensin converting enzyme inhibitors like lisinopril. You should report any signs or symptoms of angioedema immediately, such as swelling of the face, extremities, eyes, lips, or tongue, or difficulty swallowing or breathing. Do not take any more medication until you have spoken with your prescribing physician. Be cautious and report any feelings of lightheadedness, especially during the first few days of your therapy. If you experience actual fainting, please stop taking the medication and consult with your prescribing physician. Excessive sweating and dehydration can lead to a significant drop in blood pressure due to reduced fluid volume. Do not use salt substitutes that contain potassium without first consulting your physician. Promptly report any signs of infection, such as a sore throat or fever, as these may indicate neutropenia. If you are a female of childbearing age, it’s important to understand the risks of taking Lisinopril and Hydrochlorothiazide Tablets during pregnancy. Please inform your physician about any pregnancies as soon as possible. If you are taking hydrochlorothiazide, remember to protect your skin from the sun and schedule regular skin cancer screenings. Pregnancy & Lactation Milk from lactating rats may contain radioactivity after they receive lisinopril. Lisinopril was found in rat milk at levels comparable to those in the plasma of the mothers. You should consider whether to continue nursing or to stop taking Lisinopril and Hydrochlorothiazide Tablets, keeping in mind how important the medication is for your health. Side Effects You may experience dizziness (7.5 percent) You might have a headache (5.2 percent) You could develop a cough (3.9 percent) You may feel fatigued (3.7 percent) You might notice orthostatic effects (3.2 percent) You could experience diarrhea (2.5 percent) You may feel nauseous (2.2 percent) You might get an upper respiratory infection (2.2 percent) You could have muscle cramps (2.0 percent) You may feel asthenic (1.8 percent) You might experience paresthesia (1.5 percent) You could have hypotension (1.4 percent) You may experience vomiting (1.4 percent) You might have dyspepsia (1.3 percent) You could develop a rash (1.2 percent) You may experience impotence (1.2 percent) You might feel chest pain You could have abdominal pain You may experience syncope You might feel chest discomfort You could have a fever You may experience trauma You might have a virus infection You could feel palpitations You may experience orthostatic hypotension You might have gastrointestinal cramps You could experience dry mouth You may have constipation You might feel heartburn You could have back pain You may experience shoulder pain You might have knee pain You could experience back strain You may feel myalgia You might have foot pain You could experience decreased libido You may feel vertigo You might experience depression You could feel somnolent You may catch a common cold You might have nasal congestion You could catch influenza You may develop bronchitis You might experience pharyngeal pain You could have dyspnea You may experience pulmonary congestion You might have chronic sinusitis You could develop allergic rhinitis You may feel pharyngeal discomfort You might experience flushing You could have pruritus You may develop skin inflammation You might experience diaphoresis You could have blurred vision You may experience tinnitus You might have otalgia You could develop a urinary tract infection You may experience anaphylactoid reactions You might feel malaise You could have edema You may experience facial edema You might feel pain You could have pelvic pain You may experience flank pain You might feel chills You could experience cardiac arrest You may have a myocardial infarction You might experience a cerebrovascular accident You could have a pulmonary embolism You may notice worsening of heart failure You might experience arrhythmias You could have angina pectoris You may experience transient ischemic attacks You might have paroxysmal nocturnal dyspnea You could experience decreased blood pressure You may have peripheral edema You might develop vasculitis You could have pancreatitis You may experience hepatitis You might have gastritis You could experience anorexia You may have flatulence You might experience increased salivation You could have diabetes mellitus You may experience syndrome of inappropriate antidiuretic hormone secretion You might have neutropenia You could experience thrombocytopenia You may have bone marrow depression You might experience hemolytic anemia You could develop gout You may experience weight loss You might have dehydration You could experience fluid overload You may notice weight gain You might develop arthritis You could experience arthralgia You may have neck pain You might feel hip pain You could experience joint pain You may have leg pain You might feel arm pain You could experience lumbago You may have ataxia You might experience memory impairment You could have a tremor You may experience insomnia You might have a stroke You could feel nervousness You may experience confusion You might develop peripheral neuropathy You could have spasms You may experience hypersomnia You might feel irritable You could have mood alterations You may experience hallucinations You might develop malignant lung neoplasms You could have hemoptysis You may experience pulmonary edema You might have pulmonary infiltrates You could develop eosinophilic pneumonitis You may experience bronchospasm You might have asthma You could develop pleural effusion You may experience pneumonia You might have wheezing You could experience orthopnea You may have painful respiration You might experience epistaxis You could develop laryngitis You may have sinusitis You might experience pharyngitis You could develop rhinitis You may have rhinorrhea You might notice chest sound abnormalities You could develop urticaria You may experience alopecia You might have herpes zoster You could experience photosensitivity You may develop skin lesions You might have skin infections You could develop pemphigus You may experience erythema You might have psoriasis You could experience visual loss You may have diplopia You might experience photophobia You could have taste disturbances You may experience olfactory disturbances You might develop acute renal failure You could have oliguria You may experience anuria You might have uremia You could develop progressive azotemia You may experience renal dysfunction You might have muscle spasms You could feel restless You may develop erythema multiforme You might experience Stevens-Johnson syndrome You could have exfoliative dermatitis You may experience xanthopsia You might develop purpura You could experience photosensitivity You may have urticaria You might develop necrotizing angiitis You could experience respiratory distress You may have anaphylactic reactions You might experience acute transient myopia You could develop acute angle-closure glaucoma Warnings when pregnancy is detected, discontinue Lisinopril and Hydrochlorothiazide Tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus angioedema, including laryngeal edema, may occur at any time during treatment with angiotensin converting enzyme inhibitors, including lisinopril patients should report immediately any signs or symptoms suggesting angioedema (swelling of face, extremities, eyes, lips, tongue, difficulty in swallowing or breathing) and to take no more drug until they have consulted with the prescribing physician patients should be cautioned to report lightheadedness especially during the first few days of therapy if actual syncope occurs, the patients should be told to discontinue the drug until they have consulted with the prescribing physician excessive perspiration and dehydration may lead to an excessive fall in blood pressure because of reduction in fluid volume patients should be told not to use salt substitutes containing potassium without consulting their physician patients should be told to report promptly any indication of infection (e.g., sore throat, fever) which may be a sign of neutropenia female patients of childbearing age should be told about the consequences of exposure to Lisinopril and Hydrochlorothiazide Tablets during pregnancy patients should be asked to report pregnancies to their physicians as soon as possible instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening Pregnancy & Lactation milk of lactating rats contains radioactivity following administration of lisinopril lisinopril was present in rat milk at levels similar to plasma levels in the dams a decision should be made whether to discontinue nursing or to discontinue Lisinopril and Hydrochlorothiazide Tablets, taking into account the importance of the drug to the mother Side Effects dizziness (7.5 percent) headache (5.2 percent) cough (3.9 percent) fatigue (3.7 percent) orthostatic effects (3.2 percent) diarrhea (2.5 percent) nausea (2.2 percent) upper respiratory infection (2.2 percent) muscle cramps (2.0 percent) asthenia (1.8 percent) paresthesia (1.5 percent) hypotension (1.4 percent) vomiting (1.4 percent) dyspepsia (1.3 percent) rash (1.2 percent) impotence (1.2 percent) chest pain abdominal pain syncope chest discomfort fever trauma virus infection palpitation orthostatic hypotension gastrointestinal cramps dry mouth constipation heartburn back pain shoulder pain knee pain back strain myalgia foot pain decreased libido vertigo depression somnolence common cold nasal congestion influenza bronchitis pharyngeal pain dyspnea pulmonary congestion chronic sinusitis allergic rhinitis pharyngeal discomfort flushing pruritus skin inflammation diaphoresis blurred vision tinnitus otalgia urinary tract infection anaphylactoid reactions malaise edema facial edema pain pelvic pain flank pain chills cardiac arrest myocardial infarction cerebrovascular accident pulmonary embolism worsening of heart failure arrhythmias angina pectoris transient ischemic attacks paroxysmal nocturnal dyspnea decreased blood pressure peripheral edema vasculitis pancreatitis hepatitis gastritis anorexia flatulence increased salivation diabetes mellitus syndrome of inappropriate antidiuretic hormone secretion neutropenia thrombocytopenia bone marrow depression hemolytic anemia gout weight loss dehydration fluid overload weight gain arthritis arthralgia neck pain hip pain joint pain leg pain arm pain lumbago ataxia memory impairment tremor insomnia stroke nervousness confusion peripheral neuropathy spasm hypersomnia irritability mood alterations hallucinations malignant lung neoplasms hemoptysis pulmonary edema pulmonary infiltrates eosinophilic pneumonitis bronchospasm asthma pleural effusion pneumonia wheezing orthopnea painful respiration epistaxis laryngitis sinusitis pharyngitis rhinitis rhinorrhea chest sound abnormalities urticaria alopecia herpes zoster photosensitivity skin lesions skin infections pemphigus erythema psoriasis visual loss diplopia photophobia taste disturbances olfactory disturbances acute renal failure oliguria anuria uremia progressive azotemia renal dysfunction muscle spasm restlessness erythema multiforme Stevens-Johnson syndrome exfoliative dermatitis xanthopsia purpura photosensitivity urticaria necrotizing angiitis respiratory distress anaphylactic reactions acute transient myopia acute angle-closure glaucoma
Lisinopril and Hydrochlorothiazide Rx tablet GSMS, Incorporated	Popularity – score 0 out of 100 (least-viewed drug)	21 warnings	3 pregnancy and lactation warnings	189 side effects	Trend: rose 46% over 11 months.
Lisinopril and Hydrochlorothiazide® · First marketed 2025 · Label last revised February 15, 2025View full label details → Warnings If you find out you are pregnant, please stop taking Lisinopril and Hydrochlorothiazide Tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm your developing fetus. Angioedema affecting the face, extremities, lips, tongue, glottis, and/or larynx has been reported in patients treated with angiotensin-converting enzyme inhibitors, including lisinopril. In such cases, you should promptly discontinue Lisinopril and Hydrochlorothiazide Tablets, and your healthcare provider will provide the appropriate therapy and monitoring until all signs and symptoms have completely resolved. If you experience involvement of the tongue, glottis, or larynx, you may be at risk for airway obstruction, especially if you have a history of airway surgery. If you are taking both an ACE inhibitor and an mTOR inhibitor, you may have an increased risk of angioedema. Intestinal angioedema has been reported in patients treated with ACE inhibitors. If you have a history of angioedema unrelated to ACE inhibitor therapy, you may be at increased risk of angioedema while receiving an ACE inhibitor. If you are undergoing desensitizing treatment with hymenoptera venom while taking ACE inhibitors, you may experience life-threatening anaphylactoid reactions. Thiazide-containing combination products are not recommended for you if you have severe renal dysfunction. While excessive hypotension is rarely seen in uncomplicated hypertensive patients, it can occur with lisinopril use in individuals who are salt/volume-depleted. In patients with severe congestive heart failure, with or without renal insufficiency, excessive hypotension has been observed and may be linked to oliguria and/or progressive azotemia. If you experience hypotension, you should be placed in a supine position and may need an intravenous infusion of normal saline. Your healthcare provider may consider periodic monitoring of white blood cell counts if you have collagen vascular disease or renal disease. If you develop jaundice or significant elevations in hepatic enzymes while taking ACE inhibitors, you should stop the ACE inhibitor and seek appropriate medical follow-up. Please report any signs or symptoms suggesting angioedema to your healthcare provider immediately. Be cautious and report any lightheadedness, especially during the first few days of therapy. Do not use salt substitutes containing potassium without consulting your physician. Promptly report any signs of infection, as this may indicate leukopenia/neutropenia. If you are a female of childbearing age, it’s important to understand the risks of using Lisinopril and Hydrochlorothiazide Tablets during pregnancy. If you are taking hydrochlorothiazide, be sure to protect your skin from the sun and have regular skin cancer screenings. Pregnancy & Lactation Milk from lactating rats may contain radioactivity after they receive 14C lisinopril. Lisinopril was found in rat milk at levels comparable to those in the plasma of the mothers. Due to the potential for serious adverse reactions in nursing infants from ACE inhibitors and hydrochlorothiazide, you should consider whether to continue breastfeeding and/or to stop taking Lisinopril and Hydrochlorothiazide Tablets, keeping in mind how important the medication is for your health. Side Effects You may experience dizziness (7.5%). You might have a headache (5.2%). A cough (3.9%) could occur. You may feel fatigue (3.7%). Watch for orthostatic effects (3.2%). You might experience diarrhea (2.5%). You may feel nausea (2.2%). An upper respiratory infection (2.2%) could happen. You might have muscle cramps (2.0%). You may feel asthenia (1.8%). You might notice paresthesia (1.5%). Be aware of hypotension (1.4%). You may experience vomiting (1.4%). You might have dyspepsia (1.3%). You may develop a rash (1.2%). You might experience impotence (1.2%). You could feel chest pain. You may have abdominal pain. Watch for syncope. You might feel chest discomfort. You may experience a fever. Be cautious of trauma. You could have a virus infection. You might notice palpitation. Watch for orthostatic hypotension. You may experience gastrointestinal cramps. You might have a dry mouth. You may experience constipation. You could have heartburn. You might feel back pain. You may experience shoulder pain. You could have knee pain. You might experience back strain. You may feel myalgia. You could have foot pain. You might notice decreased libido. You may experience vertigo. You might feel depression. You may experience somnolence. You could catch a common cold. You might have nasal congestion. You may experience influenza. You could develop bronchitis. You might feel pharyngeal pain. You may experience dyspnea. You could have pulmonary congestion. You might experience chronic sinusitis. You may have allergic rhinitis. You could feel pharyngeal discomfort. You might notice flushing. You may experience pruritus. You could have skin inflammation. You might experience diaphoresis. You may develop cutaneous pseudolymphoma. You might notice blurred vision. You may experience tinnitus. You could have otalgia. You might develop a urinary tract infection. You may experience angioedema of the face. You could have angioedema of the extremities. You might notice angioedema of the lips. You may experience angioedema of the tongue. You could have angioedema of the glottis. You might experience angioedema of the larynx. You may develop intestinal angioedema. You could have anaphylactoid reactions. You might feel malaise. You may experience edema. You could have facial edema. You might feel pain. You may experience pelvic pain. You could have flank pain. You might feel chills. Be aware of cardiac arrest. You may experience a myocardial infarction. You could have a cerebrovascular accident. You might experience a pulmonary embolism. Watch for worsening of heart failure. You may experience arrhythmias. You might feel angina pectoris. You could have transient ischemic attacks. You may experience paroxysmal nocturnal dyspnea. You might notice decreased blood pressure. You may have peripheral edema. You could develop vasculitis. You might experience pancreatitis. You may have hepatitis. You could develop gastritis. You might experience anorexia. You may have flatulence. You could notice increased salivation. You might have diabetes mellitus. Be aware of inappropriate antidiuretic hormone secretion. You may experience bone marrow depression. You could have hemolytic anemia. You might experience leukopenia. You may have neutropenia. You could develop thrombocytopenia. You might experience gout. You may notice weight loss. Be cautious of dehydration. You might experience fluid overload. You may notice weight gain. You could have arthritis. You might feel arthralgia. You may experience neck pain. You could have hip pain. You might feel joint pain. You may experience leg pain. You could have arm pain. You might feel lumbago. You may experience ataxia. You could notice memory impairment. You might have a tremor. You may experience insomnia. Be aware of the risk of stroke. You might feel nervousness. You may experience confusion. You could have peripheral neuropathy. You might experience spasm. You may feel hypersomnia. You could feel irritability. You might notice mood alterations. Be cautious of hallucinations. You may be at risk for malignant lung neoplasms. You might experience hemoptysis. You may have pulmonary edema. You could have pulmonary infiltrates. You might experience bronchospasm. You may have asthma. You could develop a pleural effusion. You might experience pneumonia. You may have eosinophilic pneumonitis. You could notice wheezing. You might experience orthopnea. You may have painful respiration. You could have epistaxis. You might experience laryngitis. You may develop sinusitis. You could have pharyngitis. You might experience rhinitis. You may have rhinorrhea. You could notice chest sound abnormalities. You might experience urticaria. You may notice alopecia. You could have herpes zoster. Be aware of photosensitivity. You might develop skin lesions. You may have skin infections. You could develop pemphigus. You might experience erythema. You may have psoriasis. You could be at risk for toxic epidermal necrolysis. You might experience Stevens-Johnson Syndrome. You may notice visual loss. You could have diplopia. You might experience photophobia. You may notice a taste alteration. You could have an olfactory disturbance. Be aware of the risk of acute renal failure. You might experience oliguria. You may have anuria. You could experience uremia. You might have progressive azotemia. You may experience renal dysfunction. You could develop pyelonephritis. You might experience dysuria. You may feel breast pain. You might develop a rash. Be aware of photosensitivity. You could experience urticaria. You might develop necrotizing angiitis. You may experience respiratory distress. Be cautious of anaphylactic reactions. You might experience acute myopia. You may be at risk for secondary angle-closure glaucoma. You could feel weakness. You might experience gastric irritation. You may have cramping. You could develop jaundice. You might experience sialoadenitis. You may have constipation. You could feel restlessness. Be aware of the risk of renal failure. You may experience renal dysfunction. You could develop interstitial nephritis. You might experience erythema multiforme. You may have exfoliative dermatitis. You could notice xanthopsia. Warnings when pregnancy is detected, discontinue Lisinopril and Hydrochlorothiazide Tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus angioedema of the face, extremities, lips, tongue, glottis and/or larynx has been reported in patients treated with angiotensin-converting enzyme inhibitors, including lisinopril in such cases Lisinopril and Hydrochlorothiazide Tablets should be promptly discontinued and the appropriate therapy and monitoring should be provided until complete and sustained resolution of signs and symptoms has occurred patients with involvement of the tongue, glottis or larynx are likely to experience airway obstruction, especially those with a history of airway surgery patients receiving coadministration of ACE inhibitor and mTOR inhibitor may be at increased risk for angioedema intestinal angioedema has been reported in patients treated with ACE inhibitors patients with a history of angioedema unrelated to ACE inhibitor therapy may be at increased risk of angioedema while receiving an ACE inhibitor patients undergoing desensitizing treatment with hymenoptera venom while receiving ACE inhibitors sustained life-threatening anaphylactoid reactions thiazide-containing combination products are not recommended in patients with severe renal dysfunction excessive hypotension was rarely seen in uncomplicated hypertensive patients but is a possible consequence of lisinopril use in salt/volume-depleted persons in patients with severe congestive heart failure, with or without associated renal insufficiency, excessive hypotension has been observed and may be associated with oliguria and/or progressive azotemia patients should be placed in the supine position if hypotension occurs and, if necessary, receive an intravenous infusion of normal saline periodic monitoring of white blood cell counts in patients with collagen vascular disease and renal disease should be considered patients receiving ACE inhibitors who develop jaundice or marked elevations of hepatic enzymes should discontinue the ACE inhibitor and receive appropriate medical follow-up patients should be advised to report immediately any signs or symptoms suggesting angioedema patients should be cautioned to report lightheadedness especially during the first few days of therapy patients should be told not to use salt substitutes containing potassium without consulting their physician patients should be told to report promptly any indication of infection which may be a sign of leukopenia/neutropenia female patients of childbearing age should be told about the consequences of exposure to Lisinopril and Hydrochlorothiazide Tablets during pregnancy patients taking hydrochlorothiazide should protect skin from the sun and undergo regular skin cancer screening Pregnancy & Lactation milk of lactating rats contains radioactivity following administration of 14C lisinopril lisinopril was present in rat milk at levels similar to plasma levels in the dams because of the potential for serious adverse reactions in nursing infants from ACE inhibitors and hydrochlorothiazide, a decision should be made whether to discontinue nursing and/or discontinue Lisinopril and Hydrochlorothiazide Tablets, taking into account the importance of the drug to the mother Side Effects dizziness (7.5%) headache (5.2%) cough (3.9%) fatigue (3.7%) orthostatic effects (3.2%) diarrhea (2.5%) nausea (2.2%) upper respiratory infection (2.2%) muscle cramps (2.0%) asthenia (1.8%) paresthesia (1.5%) hypotension (1.4%) vomiting (1.4%) dyspepsia (1.3%) rash (1.2%) impotence (1.2%) chest pain abdominal pain syncope chest discomfort fever trauma virus infection palpitation orthostatic hypotension gastrointestinal cramps dry mouth constipation heartburn back pain shoulder pain knee pain back strain myalgia foot pain decreased libido vertigo depression somnolence common cold nasal congestion influenza bronchitis pharyngeal pain dyspnea pulmonary congestion chronic sinusitis allergic rhinitis pharyngeal discomfort flushing pruritus skin inflammation diaphoresis cutaneous pseudolymphoma blurred vision tinnitus otalgia urinary tract infection angioedema of the face angioedema of the extremities angioedema of the lips angioedema of the tongue angioedema of the glottis angioedema of the larynx intestinal angioedema anaphylactoid reactions malaise edema facial edema pain pelvic pain flank pain chills cardiac arrest myocardial infarction cerebrovascular accident pulmonary embolism worsening of heart failure arrhythmias angina pectoris transient ischemic attacks paroxysmal nocturnal dyspnea decreased blood pressure peripheral edema vasculitis pancreatitis hepatitis gastritis anorexia flatulence increased salivation diabetes mellitus inappropriate antidiuretic hormone secretion bone marrow depression hemolytic anemia leukopenia neutropenia thrombocytopenia gout weight loss dehydration fluid overload weight gain arthritis arthralgia neck pain hip pain joint pain leg pain arm pain lumbago ataxia memory impairment tremor insomnia stroke nervousness confusion peripheral neuropathy spasm hypersomnia irritability mood alterations hallucinations malignant lung neoplasms hemoptysis pulmonary edema pulmonary infiltrates bronchospasm asthma pleural effusion pneumonia eosinophilic pneumonitis wheezing orthopnea painful respiration epistaxis laryngitis sinusitis pharyngitis rhinitis rhinorrhea chest sound abnormalities urticaria alopecia herpes zoster photosensitivity skin lesions skin infections pemphigus erythema psoriasis toxic epidermal necrolysis Stevens-Johnson Syndrome visual loss diplopia photophobia taste alteration olfactory disturbance acute renal failure oliguria anuria uremia progressive azotemia renal dysfunction pyelonephritis dysuria breast pain rash photosensitivity urticaria necrotizing angiitis respiratory distress anaphylactic reactions acute myopia secondary angle-closure glaucoma weakness gastric irritation cramping jaundice sialoadenitis constipation restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme exfoliative dermatitis xanthopsia
Lisinopril and Hydrochlorothiazide Rx tablet Aurobindo Pharma Limited	Popularity – score 0 out of 100 (least-viewed drug)	13 warnings	2 pregnancy and lactation warnings	90 side effects	Trend: rose 46% over 11 months.
Lisinopril and Hydrochlorothiazide® · First marketed 2006 · Label last revised April 18, 2024View full label details → Warnings If you find out you are pregnant, please stop taking lisinopril and hydrochlorothiazide tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm your developing fetus, potentially causing injury or even death. Angioedema, including swelling of the throat, can happen at any time while you are being treated with angiotensin converting enzyme inhibitors like lisinopril. You should be aware of the signs of angioedema, such as swelling of the face, extremities, eyes, lips, or tongue, and difficulty swallowing or breathing. If you notice any of these symptoms, please stop taking the medication and consult your prescribing physician immediately. Be cautious and report any feelings of lightheadedness, especially during the first few days of your therapy. If you experience fainting, please discontinue the medication and consult your prescribing physician. Keep in mind that excessive sweating and dehydration can lead to a significant drop in blood pressure due to reduced fluid volume. Avoid using salt substitutes that contain potassium without first consulting your physician. If you notice any signs of infection, such as a sore throat or fever, please report them promptly, as they may indicate neutropenia. If you are a female of childbearing age, it's important to understand the risks associated with taking lisinopril and hydrochlorothiazide tablets during pregnancy. If you are planning to become pregnant, discuss your treatment options with your healthcare provider. Please inform your physician about any pregnancies as soon as possible. If you are taking hydrochlorothiazide, remember to protect your skin from the sun and schedule regular skin cancer screenings. Pregnancy & Lactation It is not known if lisinopril is passed into human milk. You should decide whether to continue nursing or to stop taking Lisinopril and Hydrochlorothiazide Tablets, considering how important the medication is for your health. Side Effects You may experience dizziness (7.5 percent). You might have a headache (5.2 percent). A cough (3.9 percent) could occur. You may feel fatigue (3.7 percent). Watch for orthostatic effects (3.2 percent). You might experience diarrhea (2.5 percent). You may feel nausea (2.2 percent). An upper respiratory infection (2.2 percent) could happen. You might have muscle cramps (2 percent). You may feel asthenia (1.8 percent). You might notice paresthesia (1.5 percent). Be aware of hypotension (1.4 percent). You may experience vomiting (1.4 percent). You might have dyspepsia (1.3 percent). A rash (1.2 percent) could develop. You may experience impotence (1.2 percent). You might feel chest pain. You may experience abdominal pain. Be alert for syncope. You might feel chest discomfort. You may have a fever. Trauma could occur. You might contract a virus infection. You may experience palpitations. Watch for orthostatic hypotension. You might have gastrointestinal cramps. You may experience dry mouth. You might have constipation. You may feel heartburn. You might experience back pain. You may feel shoulder pain. You might have knee pain. You may experience back strain. You might feel myalgia. You may have foot pain. You might notice decreased libido. You may experience vertigo. You might feel depression. You may experience somnolence. You might catch a common cold. You may have nasal congestion. You might contract influenza. You may experience bronchitis. You might have pharyngeal pain. You may experience dyspnea. You might have pulmonary congestion. You may suffer from chronic sinusitis. You might have allergic rhinitis. You may experience pharyngeal discomfort. You might notice flushing. You may experience pruritus. You might have skin inflammation. You may experience diaphoresis. You might notice blurred vision. You may experience tinnitus. You might have otalgia. You may develop a urinary tract infection. Be aware of angioedema. You might experience intestinal angioedema. You may experience syncope (0.8 percent). You might have hyperkalemia (1.4 percent). Acute renal failure could occur. You may experience oliguria. You might have anuria. You may experience uremia. Watch for progressive azotemia. You might have renal dysfunction. You may feel weakness. You might experience anorexia. You may have gastric irritation. You might experience cramping. You may notice jaundice (intrahepatic cholestatic jaundice). You might have leukopenia. You may experience agranulocytosis. You might have thrombocytopenia. You may experience aplastic anemia. You might have hemolytic anemia. You may experience muscle spasms. You might feel restlessness. Be aware of erythema multiforme including Stevens-Johnson syndrome. You may experience exfoliative dermatitis including toxic epidermal necrolysis. You might notice alopecia. You may experience xanthopsia. You might have purpura. You may experience photosensitivity. You might have urticaria. Be aware of necrotizing angiitis (vasculitis and cutaneous vasculitis). You may experience respiratory distress including pneumonitis and pulmonary edema. Be alert for anaphylactic reactions. You might be at risk for non-melanoma skin cancer. Warnings when pregnancy is detected, discontinue lisinopril and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus angioedema, including laryngeal edema, may occur at any time during treatment with angiotensin converting enzyme inhibitors, including lisinopril patients should be so advised and told to report immediately any signs or symptoms suggesting angioedema (swelling of face, extremities, eyes, lips, tongue, difficulty in swallowing or breathing) and to take no more drug until they have consulted with the prescribing physician patients should be cautioned to report lightheadedness especially during the first few days of therapy if actual syncope occurs, the patients should be told to discontinue the drug until they have consulted with the prescribing physician all patients should be cautioned that excessive perspiration and dehydration may lead to an excessive fall in blood pressure because of reduction in fluid volume patients should be told not to use salt substitutes containing potassium without consulting their physician patients should be told to report promptly any indication of infection (e.g., sore throat, fever) which may be a sign of neutropenia female patients of childbearing age should be told about the consequences of exposure to lisinopril and hydrochlorothiazide tablets during pregnancy discuss treatment options with women planning to become pregnant patients should be asked to report pregnancies to their physicians as soon as possible instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening Pregnancy & Lactation it is not known whether lisinopril is secreted in human milk a decision should be made whether to discontinue nursing or to discontinue Lisinopril and Hydrochlorothiazide Tablets, taking into account the importance of the drug to the mother Side Effects dizziness (7.5 percent) headache (5.2 percent) cough (3.9 percent) fatigue (3.7 percent) orthostatic effects (3.2 percent) diarrhea (2.5 percent) nausea (2.2 percent) upper respiratory infection (2.2 percent) muscle cramps (2 percent) asthenia (1.8 percent) paresthesia (1.5 percent) hypotension (1.4 percent) vomiting (1.4 percent) dyspepsia (1.3 percent) rash (1.2 percent) impotence (1.2 percent) chest pain abdominal pain syncope chest discomfort fever trauma virus infection palpitation orthostatic hypotension gastrointestinal cramps dry mouth constipation heartburn back pain shoulder pain knee pain back strain myalgia foot pain decreased libido vertigo depression somnolence common cold nasal congestion influenza bronchitis pharyngeal pain dyspnea pulmonary congestion chronic sinusitis allergic rhinitis pharyngeal discomfort flushing pruritus skin inflammation diaphoresis blurred vision tinnitus otalgia urinary tract infection angioedema intestinal angioedema syncope (0.8 percent) hyperkalemia (1.4 percent) acute renal failure oliguria anuria uremia progressive azotemia renal dysfunction weakness anorexia gastric irritation cramping jaundice (intrahepatic cholestatic jaundice) leukopenia agranulocytosis thrombocytopenia aplastic anemia hemolytic anemia muscle spasm restlessness erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia xanthopsia purpura photosensitivity urticaria necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema anaphylactic reactions non-melanoma skin cancer
Lisinopril and Hydrochlorothiazide (lisinopril and hydrochlorothiazide tablets) Rx tablet REMEDYREPACK INC.	Popularity – score 0 out of 100 (least-viewed drug)	20 warnings	4 pregnancy and lactation warnings	93 side effects	Trend: rose 46% over 11 months.
Lisinopril and Hydrochlorothiazide® · First marketed 2022 · Label last revised November 17, 2025View full label details → Warnings If you find out you are pregnant, please stop taking lisinopril and hydrochlorothiazide tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. Although rare, angioedema affecting the face, extremities, lips, tongue, glottis, and/or larynx has been reported in patients taking angiotensin converting enzyme inhibitors, including lisinopril. In such cases, you should promptly stop taking lisinopril and hydrochlorothiazide tablets, and your healthcare provider will provide appropriate therapy and monitoring until all signs and symptoms have completely resolved. If you experience involvement of the tongue, glottis, or larynx, you may be at risk for airway obstruction, especially if you have a history of airway surgery. If there is involvement of the tongue, glottis, or larynx that could cause airway obstruction, your healthcare provider should promptly administer subcutaneous epinephrine solution 1:1,000 (0.3 mL to 0.5 mL) and/or take necessary measures to ensure your airway remains open. If you have a history of angioedema unrelated to ACE-inhibitor therapy, you may be at an increased risk of angioedema while taking an ACE inhibitor. If you are taking both an ACE inhibitor and an mTOR inhibitor, you may also be at an increased risk for angioedema. Intestinal angioedema has been reported in patients treated with ACE inhibitors. You should promptly report any signs of infection, such as a sore throat or fever, as these may indicate neutropenia. If you are a female of childbearing age, it’s important to understand the potential consequences of using lisinopril and hydrochlorothiazide tablets during pregnancy. Be cautious and report any feelings of lightheadedness, especially during the first few days of therapy. If you experience actual syncope, please stop taking the medication until you have consulted with your prescribing physician. Do not use salt substitutes that contain potassium without first consulting your physician. If you experience excessive sweating and dehydration, please consult with your physician. Your healthcare provider should monitor you for clinical signs of fluid or electrolyte imbalance, such as hyponatremia, hypochloremic alkalosis, and hypokalemia. Hypokalemia can lead to cardiac arrhythmia and may increase the heart's sensitivity to the toxic effects of digitalis. You should report any signs or symptoms of angioedema, such as swelling of the face, extremities, eyes, lips, or tongue, and difficulty swallowing or breathing, and refrain from taking more medication until you have consulted with your prescribing physician. Be aware that excessive sweating and dehydration may cause a significant drop in blood pressure due to reduced fluid volume. If you experience excessive vomiting or diarrhea, please consult with your physician. Pregnancy & Lactation It is not known if lisinopril is passed into human milk. The milk of lactating rats shows radioactivity after they receive lisinopril. Lisinopril was found in rat milk at levels similar to those in the plasma of the mothers. You should decide whether to continue nursing or to stop taking lisinopril and hydrochlorothiazide tablets, considering how important the medication is for you. Side Effects You may experience dizziness (7.5%). You might have a headache (5.2%). Coughing (3.9%) can occur. Fatigue (3.7%) is also a possibility. You could notice orthostatic effects (3.2%). Diarrhea (2.5%) may happen. Nausea (2.2%) is another potential side effect. You might get an upper respiratory infection (2.2%). Muscle cramps (2.0%) can occur. You may feel asthenia (1.8%). Paresthesia (1.5%) might be experienced. Your healthcare provider may monitor you for hypotension (1.4%). Vomiting (1.4%) can happen. Dyspepsia (1.3%) is also a possibility. You might develop a rash (1.2%). Impotence (1.2%) can occur. You may experience chest pain. Abdominal pain might happen. Syncope could be a concern. You might feel chest discomfort. Fever can occur. Trauma may happen. You could be at risk for a virus infection. Palpitations might be experienced. Orthostatic hypotension is something to be aware of. Gastrointestinal cramps can occur. You may experience dry mouth. Constipation might happen. Heartburn can occur. You might feel back pain. Shoulder pain may be experienced. Knee pain could occur. Back strain might happen. You may feel myalgia. Foot pain can occur. Decreased libido might be experienced. You could feel vertigo. Depression is a potential side effect. Somnolence may occur. You might catch a common cold. Nasal congestion can happen. Influenza might be a concern. Bronchitis could occur. You may experience pharyngeal pain. Dyspnea might happen. Pulmonary congestion can occur. Chronic sinusitis may be a possibility. You might have allergic rhinitis. Pharyngeal discomfort could occur. Flushing may happen. You might experience pruritus. Skin inflammation can occur. Diaphoresis might be experienced. You may notice blurred vision. Tinnitus could occur. You might feel otalgia. A urinary tract infection may happen. Weakness can occur. Anorexia might be experienced. Gastric irritation may happen. Cramping could occur. You might experience jaundice (intrahepatic cholestatic jaundice). Pancreatitis is a potential concern. Sialadenitis may occur. Constipation might happen. Your healthcare provider may monitor you for leukopenia. Agranulocytosis could be a concern. Thrombocytopenia may occur. Aplastic anemia might happen. Hemolytic anemia could occur. You may experience muscle spasms. Restlessness might be experienced. Your healthcare provider may monitor you for renal failure. Renal dysfunction could occur. Interstitial nephritis may be a concern. Erythema multiforme including Stevens-Johnson syndrome might happen. Exfoliative dermatitis including toxic epidermal necrolysis could occur. You might experience alopecia. Xanthopsia may happen. Purpura could occur. Photosensitivity might be experienced. Urticaria may happen. Necrotizing angiitis (vasculitis and cutaneous vasculitis) could be a concern. You may experience respiratory distress including pneumonitis and pulmonary edema. Anaphylactic reactions are a serious possibility. Acute renal failure might occur. Oliguria could be a concern. Anuria may happen. Uremia might occur. Progressive azotemia could be a concern. Renal dysfunction may happen. Acute myopia might be experienced. Secondary angle-closure glaucoma is a potential risk. Warnings when pregnancy is detected, discontinue lisinopril and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus angioedema of the face, extremities, lips, tongue, glottis and/or larynx has been reported rarely in patients treated with angiotensin converting enzyme inhibitors, including lisinopril in such cases lisinopril and hydrochlorothiazide tablets should be promptly discontinued and appropriate therapy and monitoring should be provided until complete and sustained resolution of signs and symptoms has occurred patients with involvement of the tongue, glottis or larynx are likely to experience airway obstruction, especially those with a history of airway surgery where there is involvement of the tongue, glottis or larynx, likely to cause airway obstruction, subcutaneous epinephrine solution 1:1,000 (0.3 mL to 0.5 mL) and/or measures necessary to ensure a patent airway, should be promptly provided patients with a history of angioedema unrelated to ACE-inhibitor therapy may be at increased risk of angioedema while receiving an ACE inhibitor patients receiving coadministration of ACE inhibitor and mTOR inhibitor may be at increased risk for angioedema intestinal angioedema has been reported in patients treated with ACE inhibitors patients should be told to report promptly any indication of infection (e.g., sore throat, fever) which may be a sign of neutropenia female patients of childbearing age should be told about the consequences of exposure to lisinopril and hydrochlorothiazide tablets during pregnancy patients should be cautioned to report lightheadedness especially during the first few days of therapy if actual syncope occurs, the patients should be told to discontinue the drug until they have consulted with the prescribing physician patients should be told not to use salt substitutes containing potassium without consulting their physician patients should be advised to consult with their physician if excessive perspiration and dehydration occur patients should be observed for clinical signs of fluid or electrolyte imbalance: namely, hyponatremia, hypochloremic alkalosis, and hypokalemia hypokalemia may cause cardiac arrhythmia and may also sensitize or exaggerate the response of the heart to the toxic effects of digitalis patients should be advised to report any signs or symptoms suggesting angioedema (swelling of face, extremities, eyes, lips, tongue, difficulty in swallowing or breathing) and to take no more drug until they have consulted with the prescribing physician patients should be cautioned that excessive perspiration and dehydration may lead to an excessive fall in blood pressure because of reduction in fluid volume patients should be advised to consult with their physician if they experience excessive vomiting or diarrhea Pregnancy & Lactation it is not known whether lisinopril is excreted in human milk milk of lactating rats contains radioactivity following administration of C lisinopril lisinopril was present in rat milk at levels similar to plasma levels in the dams a decision should be made whether to discontinue nursing or to discontinue lisinopril and hydrochlorothiazide tablets, taking into account the importance of the drug to the mother Side Effects dizziness (7.5%) headache (5.2%) cough (3.9%) fatigue (3.7%) orthostatic effects (3.2%) diarrhea (2.5%) nausea (2.2%) upper respiratory infection (2.2%) muscle cramps (2.0%) asthenia (1.8%) paresthesia (1.5%) hypotension (1.4%) vomiting (1.4%) dyspepsia (1.3%) rash (1.2%) impotence (1.2%) chest pain abdominal pain syncope chest discomfort fever trauma virus infection palpitation orthostatic hypotension gastrointestinal cramps dry mouth constipation heartburn back pain shoulder pain knee pain back strain myalgia foot pain decreased libido vertigo depression somnolence common cold nasal congestion influenza bronchitis pharyngeal pain dyspnea pulmonary congestion chronic sinusitis allergic rhinitis pharyngeal discomfort flushing pruritus skin inflammation diaphoresis blurred vision tinnitus otalgia urinary tract infection weakness anorexia gastric irritation cramping jaundice (intrahepatic cholestatic jaundice) pancreatitis sialadenitis constipation leukopenia agranulocytosis thrombocytopenia aplastic anemia hemolytic anemia muscle spasm restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia xanthopsia purpura photosensitivity urticaria necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema anaphylactic reactions acute renal failure oliguria anuria uremia progressive azotemia renal dysfunction acute myopia secondary angle-closure glaucoma
Lisinopril and Hydrochlorothiazide (lisinopril and hydrochlorothiazide tablets) Rx tablet Cipla USA Inc.	Popularity – score 0 out of 100 (least-viewed drug)	12 warnings	2 pregnancy and lactation warnings	122 side effects	Trend: rose 46% over 11 months.
Lisinopril and Hydrochlorothiazide® · First marketed 2019 · Label last revised November 5, 2021View full label details → Warnings If you find out you are pregnant, please stop taking lisinopril and hydrochlorothiazide tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm your developing fetus, potentially causing injury or even death. Angioedema, including swelling of the larynx, can occur at any time while you are being treated with angiotensin-converting enzyme inhibitors, such as lisinopril and hydrochlorothiazide. You should be aware of the signs of angioedema (such as swelling of the face, extremities, eyes, lips, or tongue, and difficulty swallowing or breathing) and report any of these symptoms to your healthcare provider immediately. Do not take any more medication until you have consulted with them. Please let your healthcare provider know if you experience lightheadedness, especially during the first few days of your treatment. If you experience fainting, you should stop taking the medication and consult with your healthcare provider. Excessive sweating and dehydration can lead to a significant drop in blood pressure due to reduced fluid volume. Avoid using salt substitutes that contain potassium without first consulting your healthcare provider. Promptly report any signs of infection, such as a sore throat or fever, as these may indicate leukopenia or neutropenia. If you are a female of childbearing age, it’s important to understand the risks of taking lisinopril and hydrochlorothiazide during pregnancy. Please inform your healthcare provider about any pregnancies as soon as possible. If you are taking hydrochlorothiazide, remember to protect your skin from the sun and schedule regular skin cancer screenings. Pregnancy & Lactation It is not known if lisinopril is passed into human milk. You should consider whether to stop nursing and/or discontinue lisinopril and hydrochlorothiazide tablets, taking into account how important the medication is for you. Side Effects You may experience dizziness (7.5%). You might have a headache (5.2%). Coughing (3.9%) could occur. Fatigue (3.7%) is also a possibility. You may notice orthostatic effects (3.2%). Diarrhea (2.5%) can happen. Nausea (2.2%) might be experienced. An upper respiratory infection (2.2%) could develop. Muscle cramps may occur. You might feel asthenia (1.8%). Paresthesia (1.5%) could be a symptom. Hypotension (1.4%) may happen. Vomiting (1.4%) is also a possibility. Dyspepsia (1.3%) might occur. You may develop a rash (1.2%). Impotence (1.2%) could be experienced. Chest pain may arise. You might feel abdominal pain. Syncope could occur. You may experience chest discomfort. Fever might develop. Trauma could happen. A virus infection may occur. Palpitations might be felt. Orthostatic hypotension could be a concern. Gastrointestinal cramps may happen. You might experience dry mouth. Constipation could occur. Heartburn may be experienced. You might feel back pain. Shoulder pain could arise. Knee pain may occur. Back strain might happen. You may experience myalgia. Foot pain could be a symptom. Decreased libido might occur. You may feel vertigo. Depression could be experienced. Somnolence might happen. You could catch a common cold. Nasal congestion may occur. Influenza might develop. Bronchitis could be a concern. You may experience pharyngeal pain. Dyspnea might occur. Pulmonary congestion could happen. Chronic sinusitis may develop. Allergic rhinitis might be experienced. You may feel pharyngeal discomfort. Flushing could occur. Pruritus might be a symptom. Skin inflammation may happen. Diaphoresis could occur. You might experience cutaneous pseudolymphoma. Blurred vision may occur. Tinnitus could be experienced. You might feel otalgia. A urinary tract infection may develop. Weakness could be a concern. Anorexia might occur. Gastric irritation may happen. Cramping could occur. You might experience jaundice (intrahepatic cholestatic jaundice). Pancreatitis may develop. Sialoadenitis could occur. Muscle spasms might happen. You may feel restlessness. Renal failure could be a concern. Renal dysfunction might occur. Interstitial nephritis may develop. Erythema multiforme including Stevens-Johnson syndrome could occur. Exfoliative dermatitis including toxic epidermal necrolysis may happen. Alopecia might be experienced. You could notice xanthopsia. Purpura may occur. Photosensitivity might be a concern. Urticaria could develop. Necrotizing angiitis (vasculitis and cutaneous vasculitis) may occur. You might experience respiratory distress including pneumonitis and pulmonary edema. Anaphylactic reactions could happen. Malignant lung neoplasms may develop. Hemoptysis might occur. Pulmonary edema could be a concern. Pulmonary infiltrates may happen. Bronchospasm might occur. You may have asthma. Pleural effusion could develop. Pneumonia might occur. Eosinophilic pneumonitis may happen. Wheezing could be experienced. You might feel orthopnea. Painful respiration may occur. Epistaxis could happen. Laryngitis might develop. Sinusitis may occur. Pharyngitis could be a concern. Rhinitis might happen. Rhinorrhea may occur. You might notice chest sound abnormalities. Urticaria could develop. Alopecia may occur. Herpes zoster might happen. Photosensitivity could be a concern. You may experience skin lesions. Skin infections might occur. Pemphigus could develop. Erythema may happen. Psoriasis might occur. In rare cases, other severe skin reactions, including toxic epidermal necrolysis and Stevens-Johnson syndrome, may develop. You could experience visual loss. Diplopia might occur. Photophobia may happen. Taste alteration could be a concern. Olfactory disturbance might occur. Acute renal failure may develop. Oliguria could happen. Anuria might occur. Uremia may develop. Progressive azotemia could be a concern. Renal dysfunction might occur. You may feel breast pain. A symptom complex which may include a positive ANA, an elevated erythrocyte sedimentation rate, arthralgia/arthritis, myalgia, fever, vasculitis, eosinophilia, and leukocytosis could occur. Warnings when pregnancy is detected, discontinue lisinopril and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus angioedema, including laryngeal edema may occur at any time during treatment with angiotensin-converting enzyme inhibitors, including lisinopril and hydrochlorothiazide patients should be so advised and told to report immediately any signs or symptoms suggesting angioedema (swelling of face, extremities, eyes, lips, tongue, difficulty in swallowing or breathing) and to take no more drug until they have consulted with the prescribing physician patients should be cautioned to report lightheadedness especially during the first few days of therapy if actual syncope occurs, the patients should be told to discontinue the drug until they have consulted with the prescribing physician excessive perspiration and dehydration may lead to an excessive fall in blood pressure because of reduction in fluid volume patients should be told not to use salt substitutes containing potassium without consulting their physician patients should be told to report promptly any indication of infection (e.g., sore throat, fever) which may be a sign of leukopenia/neutropenia female patients of childbearing age should be told about the consequences of exposure to lisinopril and hydrochlorothiazide during pregnancy patients should be asked to report pregnancies to their physicians as soon as possible instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening Pregnancy & Lactation it is not known whether lisinopril is excreted in human milk a decision should be made whether to discontinue nursing and/or discontinue lisinopril and hydrochlorothiazide tablets taking into account the importance of the drug to the mother Side Effects dizziness (7.5%) headache (5.2%) cough (3.9%) fatigue (3.7%) orthostatic effects (3.2%) diarrhea (2.5%) nausea (2.2%) upper respiratory infection (2.2%) muscle cramps asthenia (1.8%) paresthesia (1.5%) hypotension (1.4%) vomiting (1.4%) dyspepsia (1.3%) rash (1.2%) impotence (1.2%) chest pain abdominal pain syncope chest discomfort fever trauma virus infection palpitation orthostatic hypotension gastrointestinal cramps dry mouth constipation heartburn back pain shoulder pain knee pain back strain myalgia foot pain decreased libido vertigo depression somnolence common cold nasal congestion influenza bronchitis pharyngeal pain dyspnea pulmonary congestion chronic sinusitis allergic rhinitis pharyngeal discomfort flushing pruritus skin inflammation diaphoresis cutaneous pseudolymphoma blurred vision tinnitus otalgia urinary tract infection weakness anorexia gastric irritation cramping jaundice (intrahepatic cholestatic jaundice) pancreatitis sialoadenitis muscle spasm restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia xanthopsia purpura photosensitivity urticaria necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema anaphylactic reactions malignant lung neoplasms hemoptysis pulmonary edema pulmonary infiltrates bronchospasm asthma pleural effusion pneumonia eosinophilic pneumonitis wheezing orthopnea painful respiration epistaxis laryngitis sinusitis pharyngitis rhinitis rhinorrhea chest sound abnormalities urticaria alopecia herpes zoster photosensitivity skin lesions skin infections pemphigus erythema psoriasis rare cases of other severe skin reactions, including toxic epidermal necrolysis and Stevens-Johnson syndrome visual loss diplopia photophobia taste alteration olfactory disturbance acute renal failure oliguria anuria uremia progressive azotemia renal dysfunction breast pain a symptom complex which may include a positive ANA, an elevated erythrocyte sedimentation rate, arthralgia/arthritis, myalgia, fever, vasculitis, eosinophilia and leukocytosis
Lisinopril and Hydrochlorothiazide (lisinopril and hydrochlorothiazide tablets) Rx tablet Solco Healthcare LLC	Popularity – score 0 out of 100 (least-viewed drug)	14 warnings	3 pregnancy and lactation warnings	85 side effects	Trend: rose 46% over 11 months.
Lisinopril and Hydrochlorothiazide® · First marketed 2015 · Label last revised July 25, 2025View full label details → Warnings If you find out you are pregnant, please stop taking lisinopril and hydrochlorothiazide tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm your developing fetus, potentially leading to serious injury or death. Although rare, angioedema affecting the face, extremities, lips, tongue, glottis, and/or larynx has been reported in patients treated with angiotensin converting enzyme inhibitors, including lisinopril. If you have a history of angioedema not related to ACE-inhibitor therapy, you may be at a higher risk of experiencing angioedema while taking an ACE inhibitor. If you are taking both an ACE inhibitor and an mTOR inhibitor, you may have an increased risk for angioedema. If you are on neprilysin inhibitors, you may also be at a higher risk for angioedema. While excessive hypotension is rarely seen in uncomplicated hypertensive patients, it can occur with lisinopril use in individuals who are salt or volume depleted. Syncope has been reported in 0.8 percent of patients taking lisinopril and hydrochlorothiazide tablets. In patients with severe congestive heart failure, excessive hypotension has been observed and may be linked to oliguria and/or progressive azotemia. Please report any feelings of lightheadedness, especially during the first few days of your therapy. Do not use salt substitutes that contain potassium without first consulting your physician. Promptly report any signs of infection, as this may indicate neutropenia. If you are a female of childbearing age, it’s important to understand the potential consequences of using lisinopril and hydrochlorothiazide tablets during pregnancy. If you are taking hydrochlorothiazide, remember to protect your skin from the sun and schedule regular skin cancer screenings. Pregnancy & Lactation It is not known if lisinopril is passed into human milk. Milk from lactating rats shows radioactivity after they receive lisinopril. You should decide whether to continue nursing or to stop taking lisinopril and hydrochlorothiazide tablets, considering how important the medication is for your health. Side Effects You may experience dizziness (7.5%). You might have a headache (5.2%). Coughing (3.9%) can occur. Fatigue (3.7%) is another possible side effect. You could notice orthostatic effects (3.2%). Diarrhea (2.5%) may happen. Nausea (2.2%) is also a possibility. You might get an upper respiratory infection (2.2%). Muscle cramps (2.0%) can occur. You may feel asthenia (1.8%). Paresthesia (1.5%) might be experienced. Your healthcare provider may monitor you for hypotension (1.4%). Vomiting (1.4%) can happen. Dyspepsia (1.3%) is another potential side effect. You might develop a rash (1.2%). Impotence (1.2%) can occur. You may experience chest pain. Abdominal pain might be a concern. Syncope can happen. You could feel chest discomfort. Fever may occur. Trauma can happen. You might experience a virus infection. Palpitations can occur. Orthostatic hypotension may be a concern. Gastrointestinal cramps might happen. You may notice a dry mouth. Constipation can occur. Heartburn might be experienced. You could feel back pain. Shoulder pain may occur. Knee pain might be a concern. Back strain can happen. You may experience myalgia. Foot pain might occur. Decreased libido can happen. You might feel vertigo. Depression may be a concern. Somnolence can occur. You might catch a common cold. Nasal congestion may happen. Influenza can occur. Bronchitis might be a concern. You may experience pharyngeal pain. Dyspnea can happen. Pulmonary congestion might occur. Chronic sinusitis may be a concern. You might have allergic rhinitis. Pharyngeal discomfort can occur. Flushing may happen. You might experience pruritus. Skin inflammation can occur. Diaphoresis may happen. You might notice blurred vision. Tinnitus can occur. You may experience otalgia. A urinary tract infection might happen. Weakness can occur. You might experience anorexia. Gastric irritation may be a concern. Cramping can happen. You might experience jaundice (intrahepatic cholestatic jaundice). Pancreatitis may occur. Sialadenitis can happen. Constipation might be a concern. Your healthcare provider may monitor you for leukopenia. Agranulocytosis can occur. Thrombocytopenia may be a concern. Aplastic anemia might happen. Hemolytic anemia can occur. You may experience muscle spasms. Restlessness might be a concern. Your healthcare provider may monitor you for renal failure. Renal dysfunction can occur. Interstitial nephritis may be a concern. You might experience erythema multiforme including Stevens-Johnson syndrome. Exfoliative dermatitis including toxic epidermal necrolysis can occur. Alopecia may happen. You might notice xanthopsia. Purpura can occur. Photosensitivity may be a concern. Urticaria might happen. You may experience necrotizing angiitis (vasculitis and cutaneous vasculitis). Respiratory distress including pneumonitis and pulmonary edema can occur. Anaphylactic reactions may happen. Warnings when pregnancy is detected, discontinue lisinopril and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus angioedema of the face, extremities, lips, tongue, glottis and/or larynx has been reported rarely in patients treated with angiotensin converting enzyme inhibitors, including lisinopril patients with a history of angioedema unrelated to ACE-inhibitor therapy may be at increased risk of angioedema while receiving an ACE inhibitor patients receiving coadministration of ACE inhibitor and mTOR inhibitor may be at increased risk for angioedema patients taking concomitant neprilysin inhibitors may be at increased risk for angioedema excessive hypotension was rarely seen in uncomplicated hypertensive patients but is a possible consequence of lisinopril use in salt/volume-depleted persons syncope has been reported in 0.8 percent of patients receiving lisinopril and hydrochlorothiazide tablets in patients with severe congestive heart failure, excessive hypotension has been observed and may be associated with oliguria and/or progressive azotemia patients should be cautioned to report lightheadedness especially during the first few days of therapy patients should be told not to use salt substitutes containing potassium without consulting their physician patients should be told to report promptly any indication of infection which may be a sign of neutropenia female patients of childbearing age should be told about the consequences of exposure to lisinopril and hydrochlorothiazide tablets during pregnancy instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening Pregnancy & Lactation it is not known whether lisinopril is excreted in human milk milk of lactating rats contains radioactivity following administration of lisinopril decision should be made whether to discontinue nursing or to discontinue lisinopril and hydrochlorothiazide tablets, taking into account the importance of the drug to the mother Side Effects dizziness (7.5%) headache (5.2%) cough (3.9%) fatigue (3.7%) orthostatic effects (3.2%) diarrhea (2.5%) nausea (2.2%) upper respiratory infection (2.2%) muscle cramps (2.0%) asthenia (1.8%) paresthesia (1.5%) hypotension (1.4%) vomiting (1.4%) dyspepsia (1.3%) rash (1.2%) impotence (1.2%) chest pain abdominal pain syncope chest discomfort fever trauma virus infection palpitation orthostatic hypotension gastrointestinal cramps dry mouth constipation heartburn back pain shoulder pain knee pain back strain myalgia foot pain decreased libido vertigo depression somnolence common cold nasal congestion influenza bronchitis pharyngeal pain dyspnea pulmonary congestion chronic sinusitis allergic rhinitis pharyngeal discomfort flushing pruritus skin inflammation diaphoresis blurred vision tinnitus otalgia urinary tract infection weakness anorexia gastric irritation cramping jaundice (intrahepatic cholestatic jaundice) pancreatitis sialadenitis constipation leukopenia agranulocytosis thrombocytopenia aplastic anemia hemolytic anemia muscle spasm restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia xanthopsia purpura photosensitivity urticaria necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema anaphylactic reactions
Lisinopril and Hydrochlorothiazide (lisinopril and hydrochlorothiazide tablets) Rx tablet Exelan Pharmaceuticals, Inc.	Popularity – score 0 out of 100 (least-viewed drug)	14 warnings	1 pregnancy and lactation warnings	170 side effects	Trend: rose 46% over 11 months.
Lisinopril and Hydrochlorothiazide® · First marketed 2019 · Label last revised March 28, 2023View full label details → Warnings If you find out you are pregnant, please stop taking lisinopril and hydrochlorothiazide tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm your developing fetus, potentially causing injury or even death. If you are taking ACE inhibitors, be aware that you may experience various adverse reactions, some of which can be serious. Angioedema, including swelling in the throat, can occur at any time while you are being treated with angiotensin-converting enzyme inhibitors like lisinopril and hydrochlorothiazide. You should report any signs or symptoms of angioedema immediately, such as swelling of the face, extremities, eyes, lips, or tongue, or difficulty swallowing or breathing. Please do not take any more medication until you have consulted with your prescribing physician. Be cautious and report any feelings of lightheadedness, especially during the first few days of your therapy. If you experience actual fainting, please stop taking the medication until you have spoken with your prescribing physician. Excessive sweating and dehydration can lead to a significant drop in blood pressure due to reduced fluid volume, so be mindful of this. If you are experiencing other causes of volume depletion, such as vomiting or diarrhea, please consult with your physician, as these can also lead to a drop in blood pressure. Do not use salt substitutes that contain potassium without first consulting your physician. Promptly report any signs of infection, such as a sore throat or fever, as these may indicate leukopenia or neutropenia. If you are a female of childbearing age, it’s important to understand the risks of taking lisinopril and hydrochlorothiazide during pregnancy. Please inform your physician about any pregnancies as soon as possible. If you are taking hydrochlorothiazide, remember to protect your skin from the sun and schedule regular skin cancer screenings. Pregnancy & Lactation You should consider whether to stop nursing and/or discontinue lisinopril and hydrochlorothiazide tablets, keeping in mind how important the medication is for you. Side Effects You may experience dizziness in 7.5% of patients. You might have a headache in 5.2% of patients. A cough could occur in 3.9% of patients. You may feel fatigue in 3.7% of patients. You might notice orthostatic effects in 3.2% of patients. You could experience diarrhea in 2.5% of patients. You may feel nausea in 2.2% of patients. An upper respiratory infection could occur in 2.2% of patients. You might have muscle cramps in 2.0% of patients. You may feel asthenia in 1.8% of patients. You could experience paresthesia in 1.5% of patients. Your healthcare provider may monitor you for hypotension in 1.4% of patients. You might experience vomiting in 1.4% of patients. You may have dyspepsia in 1.3% of patients. You could develop a rash in 1.2% of patients. You might experience impotence in 1.2% of patients. You may experience chest pain. You might have abdominal pain. You could experience syncope. You may feel chest discomfort. You might develop a fever. You could experience trauma. You may have a virus infection. You might notice palpitations. You may experience orthostatic hypotension. You could have gastrointestinal cramps. You might experience dry mouth. You may have constipation. You could feel heartburn. You might experience back pain. You may feel shoulder pain. You could have knee pain. You might experience back strain. You may have myalgia. You could feel foot pain. You might notice decreased libido. You may experience vertigo. You could feel depression. You might experience somnolence. You may catch a common cold. You might have nasal congestion. You could catch influenza. You may develop bronchitis. You might experience pharyngeal pain. You could have dyspnea. You may experience pulmonary congestion. You might have chronic sinusitis. You could develop allergic rhinitis. You may feel pharyngeal discomfort. You might experience flushing. You could have pruritus. You may experience skin inflammation. You might have diaphoresis. You could develop cutaneous pseudolymphoma. You may experience blurred vision. You might notice tinnitus. You could have otalgia. You may develop a urinary tract infection. You might experience angioedema of the face, extremities, lips, tongue, glottis and/or larynx. You could have intestinal angioedema. Your healthcare provider may monitor you for hypotension (1.4%). Your healthcare provider may check for orthostatic hypotension (0.5%). You might experience other orthostatic effects (3.2%). You may have syncope in 0.8% of patients. You could experience anaphylactoid reactions. You might feel malaise. You may have edema. You could experience facial edema. You might feel pain. You may have pelvic pain. You could experience flank pain. You might feel chills. You may experience cardiac arrest. You could have a myocardial infarction. You might experience a cerebrovascular accident. You may have a pulmonary embolism. You could experience infarction. You might notice worsening of heart failure. You may experience arrhythmias. You could have angina pectoris. You might experience transient ischemic attacks. You may have paroxysmal nocturnal dyspnea. Your healthcare provider may monitor you for decreased blood pressure. You might experience peripheral edema. You could have vasculitis. You may develop pancreatitis. You might experience hepatitis. You could have gastritis. You may experience anorexia. You might have flatulence. You could notice increased salivation. You may develop diabetes mellitus. You might experience inappropriate antidiuretic hormone secretion. There are rare cases of bone marrow depression. You could experience hemolytic anemia. You may have leukopenia/neutropenia. You might experience thrombocytopenia. You could develop gout. You may notice weight loss. You might experience dehydration. You could have fluid overload. You may notice weight gain. You might develop arthritis. You could experience arthralgia. You may have neck pain. You might feel hip pain. You could experience joint pain. You may have leg pain. You might feel arm pain. You could experience lumbago. You may have ataxia. You might experience memory impairment. You could have tremors. You may experience insomnia. You might have a stroke. You could feel nervousness. You may experience confusion. You might have peripheral neuropathy. You could experience spasms. You may have hypersomnia. You might feel irritability. You could experience mood alterations. You may have hallucinations. There are reports of malignant lung neoplasms. You might experience hemoptysis. You could have pulmonary edema. You may have pulmonary infiltrates. You might experience bronchospasm. You may have asthma. You could develop pleural effusion. You might catch pneumonia. You may experience eosinophilic pneumonitis. You could have wheezing. You might experience orthopnea. You may have painful respiration. You could experience epistaxis. You might develop laryngitis. You may have sinusitis. You could experience pharyngitis. You might have rhinitis. You may experience rhinorrhea. You could notice chest sound abnormalities. You might develop urticaria. You may experience alopecia. You could have herpes zoster. You might experience photosensitivity. You may have skin lesions. You could develop skin infections. You might experience pemphigus. You may have erythema. You could develop psoriasis. You might experience toxic epidermal necrolysis. You may have Stevens-Johnson Syndrome. You could experience visual loss. You might have diplopia. You may experience photophobia. You could notice taste alteration. You might have olfactory disturbance. You may experience acute renal failure. You could have oliguria. You might experience anuria. You may have uremia. You could experience progressive azotemia. You might have renal dysfunction. You may develop a rash. You could experience photosensitivity. You might have urticaria. You may develop necrotizing angiitis. You could experience respiratory distress. You might have anaphylactic reactions. Warnings when pregnancy is detected, discontinue lisinopril and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus patients receiving ACE inhibitors may be subject to a variety of adverse reactions, some of them serious angioedema, including laryngeal edema may occur at any time during treatment with angiotensin-converting enzyme inhibitors, including lisinopril and hydrochlorothiazide patients should report immediately any signs or symptoms suggesting angioedema (swelling of face, extremities, eyes, lips, tongue, difficulty in swallowing or breathing) and to take no more drug until they have consulted with the prescribing physician patients should be cautioned to report lightheadedness especially during the first few days of therapy if actual syncope occurs, the patients should be told to discontinue the drug until they have consulted with the prescribing physician patients should be advised that excessive perspiration and dehydration may lead to an excessive fall in blood pressure because of reduction in fluid volume patients should be advised to consult with their physician if other causes of volume depletion such as vomiting or diarrhea may also lead to a fall in blood pressure patients should be told not to use salt substitutes containing potassium without consulting their physician patients should be told to report promptly any indication of infection (e.g., sore throat, fever) which may be a sign of leukopenia/neutropenia female patients of childbearing age should be told about the consequences of exposure to lisinopril and hydrochlorothiazide during pregnancy patients should be asked to report pregnancies to their physicians as soon as possible instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening Pregnancy & Lactation a decision should be made whether to discontinue nursing and/or discontinue lisinopril and hydrochlorothiazide tablets taking into account the importance of the drug to the mother Side Effects dizziness in 7.5% of patients headache in 5.2% of patients cough in 3.9% of patients fatigue in 3.7% of patients orthostatic effects in 3.2% of patients diarrhea in 2.5% of patients nausea in 2.2% of patients upper respiratory infection in 2.2% of patients muscle cramps in 2.0% of patients asthenia in 1.8% of patients paresthesia in 1.5% of patients hypotension in 1.4% of patients vomiting in 1.4% of patients dyspepsia in 1.3% of patients rash in 1.2% of patients impotence in 1.2% of patients chest pain abdominal pain syncope chest discomfort fever trauma virus infection palpitation orthostatic hypotension gastrointestinal cramps dry mouth constipation heartburn back pain shoulder pain knee pain back strain myalgia foot pain decreased libido vertigo depression somnolence common cold nasal congestion influenza bronchitis pharyngeal pain dyspnea pulmonary congestion chronic sinusitis allergic rhinitis pharyngeal discomfort flushing pruritus skin inflammation diaphoresis cutaneous pseudolymphoma blurred vision tinnitus otalgia urinary tract infection angioedema of the face, extremities, lips, tongue, glottis and/or larynx intestinal angioedema hypotension (1.4%) orthostatic hypotension (0.5%) other orthostatic effects (3.2%) syncope in 0.8% of patients anaphylactoid reactions malaise edema facial edema pain pelvic pain flank pain chills cardiac arrest myocardial infarction cerebrovascular accident pulmonary embolism infarction worsening of heart failure arrhythmias angina pectoris transient ischemic attacks paroxysmal nocturnal dyspnea decreased blood pressure peripheral edema vasculitis pancreatitis hepatitis gastritis anorexia flatulence increased salivation diabetes mellitus inappropriate antidiuretic hormone secretion rare cases of bone marrow depression hemolytic anemia leukopenia/neutropenia thrombocytopenia gout weight loss dehydration fluid overload weight gain arthritis arthralgia neck pain hip pain joint pain leg pain arm pain lumbago ataxia memory impairment tremor insomnia stroke nervousness confusion peripheral neuropathy spasm hypersomnia irritability mood alterations hallucinations malignant lung neoplasms hemoptysis pulmonary edema pulmonary infiltrates bronchospasm asthma pleural effusion pneumonia eosinophilic pneumonitis wheezing orthopnea painful respiration epistaxis laryngitis sinusitis pharyngitis rhinitis rhinorrhea chest sound abnormalities urticaria alopecia herpes zoster photosensitivity skin lesions skin infections pemphigus erythema psoriasis toxic epidermal necrolysis Stevens-Johnson Syndrome visual loss diplopia photophobia taste alteration olfactory disturbance acute renal failure oliguria anuria uremia progressive azotemia renal dysfunction rash photosensitivity urticaria necrotizing angiitis respiratory distress anaphylactic reactions
Lisinopril and Hydrochlorothiazide (lisinopril and hydrochlorothiazide tablets) Rx tablet REMEDYREPACK INC.	Popularity – score 0 out of 100 (least-viewed drug)	22 warnings	2 pregnancy and lactation warnings	93 side effects	Trend: rose 46% over 11 months.
Lisinopril and Hydrochlorothiazide® · First marketed 2025 · Label last revised November 6, 2025View full label details → Warnings If you find out you are pregnant, please stop taking lisinopril and hydrochlorothiazide tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. Although rare, angioedema affecting the face, extremities, lips, tongue, glottis, and/or larynx has been reported in patients treated with angiotensin converting enzyme inhibitors, including lisinopril. In such cases, you should promptly stop taking lisinopril and hydrochlorothiazide tablets, and your healthcare provider will need to provide appropriate therapy and monitoring until all signs and symptoms have completely resolved. If you experience involvement of the tongue, glottis, or larynx, you may be at risk for airway obstruction, especially if you have a history of airway surgery. If there is involvement of the tongue, glottis, or larynx that could cause airway obstruction, your healthcare provider should promptly administer subcutaneous epinephrine solution 1:1,000 (0.3 mL to 0.5 mL) and/or take necessary measures to ensure your airway remains open. If you have a history of angioedema unrelated to ACE-inhibitor therapy, you may be at an increased risk of angioedema while taking an ACE inhibitor. If you are taking both an ACE inhibitor and an mTOR inhibitor, you may also be at an increased risk for angioedema. Intestinal angioedema has been reported in patients treated with ACE inhibitors. You should report any signs or symptoms of angioedema immediately, such as swelling of the face, extremities, eyes, lips, tongue, or any difficulty in swallowing or breathing, and refrain from taking any more medication until you have consulted with your prescribing physician. Please be cautious and report any feelings of lightheadedness, especially during the first few days of your therapy. If you experience actual fainting, you should stop taking the medication until you have consulted with your prescribing physician. Do not use salt substitutes that contain potassium without first consulting your physician. You should promptly report any signs of infection, such as a sore throat or fever, as these may indicate neutropenia. If you are a female of childbearing age, it’s important to understand the potential consequences of taking lisinopril and hydrochlorothiazide tablets during pregnancy. Please inform your physician about any pregnancies as soon as possible. If you are taking hydrochlorothiazide, remember to protect your skin from the sun and schedule regular skin cancer screenings. If you experience hypotension, you should lie down and, if necessary, receive an intravenous infusion of normal saline. If you have severe congestive heart failure, your healthcare provider will need to monitor you closely for the first two weeks of treatment and whenever your dose of lisinopril and/or diuretic is increased. You should be observed for clinical signs of fluid or electrolyte imbalance, including hyponatremia, hypochloremic alkalosis, and hypokalemia. Be aware that excessive sweating and dehydration may lead to a significant drop in blood pressure due to reduced fluid volume. If you notice progressive renal impairment, consider discussing with your healthcare provider the possibility of withholding or discontinuing diuretic therapy. Pregnancy & Lactation It is not known if lisinopril is passed into human milk. You should decide whether to stop nursing or to discontinue lisinopril and hydrochlorothiazide tablets, considering how important the medication is for you. Side Effects You may experience dizziness (7.5%). You might have a headache (5.2%). Coughing (3.9%) could occur. Fatigue (3.7%) is also a possibility. You may notice orthostatic effects (3.2%). Diarrhea (2.5%) can happen. Nausea (2.2%) might be experienced. You could develop an upper respiratory infection (2.2%). Muscle cramps (2.0%) may occur. You might feel asthenia (1.8%). Paresthesia (1.5%) could be a symptom. Your healthcare provider may monitor you for hypotension (1.4%). Vomiting (1.4%) is another possible side effect. Dyspepsia (1.3%) may occur. You might notice a rash (1.2%). Impotence (1.2%) could be experienced. Chest pain is something to be aware of. You may feel abdominal pain. Syncope is a potential concern. Chest discomfort might occur. Fever could be a symptom. Trauma may happen. You might contract a virus infection. Palpitations could be experienced. Orthostatic hypotension is something to watch for. Gastrointestinal cramps may occur. You might experience dry mouth. Constipation could be a side effect. Heartburn may happen. You might feel back pain. Shoulder pain could occur. Knee pain is also a possibility. Back strain might happen. You may experience myalgia. Foot pain could be a concern. Decreased libido might occur. You may feel vertigo. Depression is a potential side effect. Somnolence could be experienced. You might catch a common cold. Nasal congestion may occur. Influenza could be a concern. Bronchitis might happen. You may experience pharyngeal pain. Dyspnea could occur. Pulmonary congestion might be experienced. Chronic sinusitis is something to be aware of. You might have allergic rhinitis. Pharyngeal discomfort could occur. Flushing may happen. You might experience pruritus. Skin inflammation could be a side effect. Diaphoresis may occur. You might notice blurred vision. Tinnitus could be experienced. You may feel otalgia. A urinary tract infection might occur. Weakness could be a concern. Anorexia may happen. Gastric irritation might occur. Cramping could be experienced. You may develop jaundice (intrahepatic cholestatic jaundice). Pancreatitis is a potential side effect. Sialadenitis might occur. Constipation could happen. Your healthcare provider may monitor you for leukopenia. Agranulocytosis is a serious condition to be aware of. Thrombocytopenia might occur. Aplastic anemia is a potential concern. Hemolytic anemia could be experienced. Muscle spasms may happen. You might feel restlessness. Your healthcare provider may monitor you for renal failure. Renal dysfunction could occur. Interstitial nephritis is a potential side effect. Erythema multiforme including Stevens-Johnson syndrome is a serious condition. Exfoliative dermatitis including toxic epidermal necrolysis may occur. Alopecia could be experienced. You might notice xanthopsia. Purpura may happen. Photosensitivity is something to be aware of. Urticaria could occur. Necrotizing angiitis (vasculitis and cutaneous vasculitis) is a serious condition. Respiratory distress including pneumonitis and pulmonary edema may occur. Anaphylactic reactions are a serious concern. Acute renal failure might happen. Oliguria could be experienced. Anuria is a potential side effect. Uremia may occur. Progressive azotemia is something to monitor. Renal dysfunction could happen. Acute myopia might occur. Secondary angle-closure glaucoma is a serious condition to be aware of. Warnings when pregnancy is detected, discontinue lisinopril and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus angioedema of the face, extremities, lips, tongue, glottis and/or larynx has been reported rarely in patients treated with angiotensin converting enzyme inhibitors, including lisinopril in such cases lisinopril and hydrochlorothiazide tablets should be promptly discontinued and appropriate therapy and monitoring should be provided until complete and sustained resolution of signs and symptoms has occurred patients with involvement of the tongue, glottis or larynx are likely to experience airway obstruction, especially those with a history of airway surgery where there is involvement of the tongue, glottis or larynx, likely to cause airway obstruction, subcutaneous epinephrine solution 1:1,000 (0.3 mL to 0.5 mL) and/or measures necessary to ensure a patent airway, should be promptly provided patients with a history of angioedema unrelated to ACE-inhibitor therapy may be at increased risk of angioedema while receiving an ACE inhibitor patients receiving coadministration of ACE inhibitor and mTOR inhibitor may be at increased risk for angioedema intestinal angioedema has been reported in patients treated with ACE inhibitors patients should be told to report immediately any signs or symptoms suggesting angioedema (swelling of face, extremities, eyes, lips, tongue, difficulty in swallowing or breathing) and to take no more drug until they have consulted with the prescribing physician patients should be cautioned to report lightheadedness especially during the first few days of therapy if actual syncope occurs, the patients should be told to discontinue the drug until they have consulted with the prescribing physician patients should be told not to use salt substitutes containing potassium without consulting their physician patients should be told to report promptly any indication of infection (e.g., sore throat, fever) which may be a sign of neutropenia female patients of childbearing age should be told about the consequences of exposure to lisinopril and hydrochlorothiazide tablets during pregnancy patients should be asked to report pregnancies to their physicians as soon as possible instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening if hypotension occurs, the patient should be placed in supine position and, if necessary, receive an intravenous infusion of normal saline patients with severe congestive heart failure should be followed closely for the first two weeks of treatment and whenever the dose of lisinopril and/or diuretic is increased patients should be observed for clinical signs of fluid or electrolyte imbalance: namely, hyponatremia, hypochloremic alkalosis, and hypokalemia patients should be cautioned that excessive perspiration and dehydration may lead to an excessive fall in blood pressure because of reduction in fluid volume if progressive renal impairment becomes evident consider withholding or discontinuing diuretic therapy Pregnancy & Lactation it is not known whether lisinopril is excreted in human milk a decision should be made whether to discontinue nursing or to discontinue lisinopril and hydrochlorothiazide tablets, taking into account the importance of the drug to the mother Side Effects dizziness (7.5%) headache (5.2%) cough (3.9%) fatigue (3.7%) orthostatic effects (3.2%) diarrhea (2.5%) nausea (2.2%) upper respiratory infection (2.2%) muscle cramps (2.0%) asthenia (1.8%) paresthesia (1.5%) hypotension (1.4%) vomiting (1.4%) dyspepsia (1.3%) rash (1.2%) impotence (1.2%) chest pain abdominal pain syncope chest discomfort fever trauma virus infection palpitation orthostatic hypotension gastrointestinal cramps dry mouth constipation heartburn back pain shoulder pain knee pain back strain myalgia foot pain decreased libido vertigo depression somnolence common cold nasal congestion influenza bronchitis pharyngeal pain dyspnea pulmonary congestion chronic sinusitis allergic rhinitis pharyngeal discomfort flushing pruritus skin inflammation diaphoresis blurred vision tinnitus otalgia urinary tract infection weakness anorexia gastric irritation cramping jaundice (intrahepatic cholestatic jaundice) pancreatitis sialadenitis constipation leukopenia agranulocytosis thrombocytopenia aplastic anemia hemolytic anemia muscle spasm restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis alopecia xanthopsia purpura photosensitivity urticaria necrotizing angiitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema anaphylactic reactions acute renal failure oliguria anuria uremia progressive azotemia renal dysfunction acute myopia secondary angle-closure glaucoma
Losartan Potassium and Hydrochlorothiazide Rx tablet, film coated REMEDYREPACK INC.	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	0 pregnancy and lactation warnings	7 side effects	Trend: rose 48% over 11 months.
Losartan Potassium and Hydrochlorothiazide® · First marketed 2022 · Label last revised July 22, 2025View full label details → Warnings If you find out you are pregnant, please stop taking losartan potassium and hydrochlorothiazide tablets as soon as possible. Be aware that medications affecting the renin-angiotensin system can harm the developing fetus and may lead to serious complications. Make sure to correct any volume or salt depletion before starting losartan potassium and hydrochlorothiazide tablets. Your healthcare provider should regularly check your renal function and potassium levels if you are at risk. Keep an eye out for any signs of fluid or electrolyte imbalance. Be cautious of acute angle-closure glaucoma. This medication may worsen systemic lupus erythematosus. Pregnancy & Lactation No pregnancy & lactation warnings reported. Side Effects You may experience dizziness. You might develop an upper respiratory infection. Coughing could occur. You may feel back pain. Watch for signs of hypotension. There is a risk of acute angle-closure glaucoma. You may see an exacerbation of systemic lupus erythematosus. Warnings when pregnancy is detected, discontinue losartan potassium and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume or salt depletion prior to administration of losartan potassium and hydrochlorothiazide tablets monitor renal function and potassium in susceptible patients observe for clinical signs of fluid or electrolyte imbalance acute angle-closure glaucoma exacerbation of systemic lupus erythematosus Pregnancy & Lactation No pregnancy & lactation warnings reported. Side Effects dizziness upper respiratory infection cough back pain hypotension acute angle-closure glaucoma exacerbation of systemic lupus erythematosus
Losartan Potassium and Hydrochlorothiazide Rx tablet, film coated NorthStar Rx LLC	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	13 pregnancy and lactation warnings	7 side effects	Trend: rose 48% over 11 months.
Losartan Potassium and Hydrochlorothiazide® · First marketed 2024 · Label last revised September 6, 2025View full label details → Warnings If you find out you are pregnant, please stop taking losartan potassium and hydrochlorothiazide tablets as soon as possible. Be aware that medications affecting the renin-angiotensin system can harm the developing fetus and may lead to serious complications. Make sure to correct any volume or salt depletion before starting losartan potassium and hydrochlorothiazide. Your healthcare provider should regularly check your renal function and potassium levels if you are at risk. Keep an eye out for any signs of fluid or electrolyte imbalance. Be cautious of acute angle-closure glaucoma. This medication may worsen systemic lupus erythematosus. Pregnancy & Lactation Losartan potassium and hydrochlorothiazide can cause harm to the fetus if you take them while pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please stop taking losartan potassium and hydrochlorothiazide as soon as possible. High blood pressure during pregnancy raises your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for your baby, including intrauterine growth restriction and intrauterine death. Taking medications that act on the renin-angiotensin system in the second and third trimesters of pregnancy may lead to oligohydramnios, reduced kidney function in the fetus, which can cause anuria and renal failure, fetal lung underdevelopment, skeletal deformities such as skull hypoplasia, low blood pressure, and even death. If oligohydramnios is detected, you should stop taking losartan potassium and hydrochlorothiazide unless your healthcare provider determines it is essential for your health. Thiazides can cross the placenta, and the levels in the umbilical vein can be similar to those in your bloodstream. Using thiazides during pregnancy may increase the risk of jaundice or low platelet counts in your baby. It's best to avoid using hydrochlorothiazide for other conditions during pregnancy. It is unclear if losartan passes into human breast milk, but significant amounts have been found in rat milk. Thiazides do appear in human milk. Due to the potential risks to your nursing infant, you should discuss with your healthcare provider whether to continue breastfeeding or to stop taking the medication. Side Effects You may experience dizziness. You could develop an upper respiratory infection. A cough may occur. You might feel back pain. Be aware of the possibility of hypotension. Your healthcare provider should monitor you for acute angle-closure glaucoma. There may be an exacerbation of systemic lupus erythematosus. Warnings when pregnancy is detected, discontinue losartan potassium and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume or salt depletion prior to administration of losartan potassium and hydrochlorothiazide monitor renal function and potassium in susceptible patients observe for clinical signs of fluid or electrolyte imbalance acute angle-closure glaucoma exacerbation of systemic lupus erythematosus Pregnancy & Lactation losartan potassium and hydrochlorothiazide can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue losartan potassium and hydrochlorothiazide as soon as possible hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death use of drugs that act on the renin-angiotensin system in the second and third trimesters of pregnancy can result in oligohydramnios, reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death if oligohydramnios is observed, discontinue losartan potassium and hydrochlorothiazide, unless it is considered lifesaving for the mother thiazides can cross the placenta, and concentrations reached in the umbilical vein approach those in the maternal plasma use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia the use of hydrochlorothiazide for other indications in pregnancy should be avoided it is not known whether losartan is excreted in human milk, but significant levels of losartan and its active metabolite were shown to be present in rat milk thiazides appear in human milk because of the potential for adverse effects on the nursing infant, a decision should be made whether to discontinue nursing or discontinue the drug Side Effects dizziness upper respiratory infection cough back pain hypotension acute angle-closure glaucoma exacerbation of systemic lupus erythematosus
Losartan Potassium and Hydrochlorothiazide Rx tablet, film coated REMEDYREPACK INC.	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	0 pregnancy and lactation warnings	7 side effects	Trend: rose 48% over 11 months.
Losartan Potassium and Hydrochlorothiazide® · First marketed 2022 · Label last revised September 16, 2025View full label details → Warnings If you find out you are pregnant, please stop taking losartan potassium and hydrochlorothiazide tablets as soon as possible. Be aware that medications affecting the renin-angiotensin system can harm the developing fetus and may lead to serious complications. Make sure to correct any volume or salt depletion before starting losartan potassium and hydrochlorothiazide tablets. Your healthcare provider should regularly check your renal function and potassium levels if you are at risk. Keep an eye out for any signs of fluid or electrolyte imbalance. Be cautious of acute angle-closure glaucoma. This medication may worsen systemic lupus erythematosus. Pregnancy & Lactation No pregnancy & lactation warnings reported. Side Effects You may experience dizziness. You might develop an upper respiratory infection. Coughing could occur. You may feel back pain. Watch for signs of hypotension. There is a risk of acute angle-closure glaucoma. You may notice an exacerbation of systemic lupus erythematosus. Warnings when pregnancy is detected, discontinue losartan potassium and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume or salt depletion prior to administration of losartan potassium and hydrochlorothiazide tablets monitor renal function and potassium in susceptible patients observe for clinical signs of fluid or electrolyte imbalance acute angle-closure glaucoma exacerbation of systemic lupus erythematosus Pregnancy & Lactation No pregnancy & lactation warnings reported. Side Effects dizziness upper respiratory infection cough back pain hypotension acute angle-closure glaucoma exacerbation of systemic lupus erythematosus
Losartan Potassium and Hydrochlorothiazide Rx tablet, film coated Solco Healthcare US, LLC	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	0 pregnancy and lactation warnings	7 side effects	Trend: rose 48% over 11 months.
Losartan Potassium and Hydrochlorothiazide® · First marketed 2018 · Label last revised March 31, 2025View full label details → Warnings If you find out you are pregnant, please stop taking losartan potassium and hydrochlorothiazide tablets as soon as possible. Be aware that medications affecting the renin-angiotensin system can harm the developing fetus and may lead to serious complications. Make sure to correct any volume or salt depletion before starting losartan potassium and hydrochlorothiazide tablets. Your healthcare provider should regularly check your renal function and potassium levels if you are at risk. Keep an eye out for any signs of fluid or electrolyte imbalance. Be cautious of acute angle-closure glaucoma. This medication may worsen systemic lupus erythematosus. Pregnancy & Lactation No pregnancy & lactation warnings reported. Side Effects You may experience dizziness. You could develop an upper respiratory infection. A cough might occur. You may feel back pain. You might experience hypotension. Your healthcare provider should monitor you for acute angle-closure glaucoma. There may be an exacerbation of systemic lupus erythematosus. Warnings when pregnancy is detected, discontinue losartan potassium and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume or salt depletion prior to administration of losartan potassium and hydrochlorothiazide tablets monitor renal function and potassium in susceptible patients observe for clinical signs of fluid or electrolyte imbalance acute angle-closure glaucoma exacerbation of systemic lupus erythematosus Pregnancy & Lactation No pregnancy & lactation warnings reported. Side Effects dizziness upper respiratory infection cough back pain hypotension acute angle-closure glaucoma exacerbation of systemic lupus erythematosus
Losartan Potassium and Hydrochlorothiazide Rx tablet, film coated REMEDYREPACK INC.	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	13 pregnancy and lactation warnings	7 side effects	Trend: rose 48% over 11 months.
Losartan Potassium and Hydrochlorothiazide® · First marketed 2020 · Label last revised September 4, 2025View full label details → Warnings If you find out you are pregnant, please stop taking losartan potassium and hydrochlorothiazide tablets as soon as possible. Be aware that medications affecting the renin-angiotensin system can harm the developing fetus and may lead to serious complications. Make sure to correct any volume or salt depletion before starting losartan potassium and hydrochlorothiazide. Your healthcare provider should regularly check your renal function and potassium levels if you are at risk. Keep an eye out for any signs of fluid or electrolyte imbalance. Be cautious of acute angle-closure glaucoma. This medication may worsen systemic lupus erythematosus. Pregnancy & Lactation If you are pregnant, be aware that losartan potassium and hydrochlorothiazide can cause harm to the fetus. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase the risk of complications for both the fetus and newborn. Once you confirm your pregnancy, please discontinue losartan potassium and hydrochlorothiazide as soon as possible. Hypertension during pregnancy can increase your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for the fetus, including intrauterine growth restriction and intrauterine death. Taking medications that act on the renin-angiotensin system in the second and third trimesters of pregnancy may lead to oligohydramnios, reduced fetal kidney function resulting in anuria and renal failure, fetal lung underdevelopment, skeletal deformities such as skull hypoplasia, low blood pressure, and even death. If oligohydramnios is detected, you should stop taking losartan potassium and hydrochlorothiazide unless your healthcare provider determines it is essential for your health. Thiazides can cross the placenta, and the levels in the umbilical vein can be similar to those in your bloodstream. Using thiazides during pregnancy may carry a risk of fetal or neonatal jaundice or low platelet counts. It's advisable to avoid using hydrochlorothiazide for other conditions during pregnancy. It is unclear if losartan is present in human milk, but significant amounts of losartan and its active metabolite have been found in rat milk. Thiazides can appear in human milk. Due to the potential risks to your nursing infant, you should consider whether to continue breastfeeding or to stop taking the medication. Side Effects You may experience dizziness. You might develop an upper respiratory infection. Coughing could occur. You may feel back pain. Watch for signs of hypotension. There is a risk of acute angle-closure glaucoma. You may see an exacerbation of systemic lupus erythematosus. Warnings when pregnancy is detected, discontinue losartan potassium and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume or salt depletion prior to administration of losartan potassium and hydrochlorothiazide monitor renal function and potassium in susceptible patients observe for clinical signs of fluid or electrolyte imbalance acute angle-closure glaucoma exacerbation of systemic lupus erythematosus Pregnancy & Lactation losartan potassium and hydrochlorothiazide can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue losartan potassium and hydrochlorothiazide as soon as possible hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death use of drugs that act on the renin-angiotensin system in the second and third trimesters of pregnancy can result in oligohydramnios, reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death if oligohydramnios is observed, discontinue losartan potassium and hydrochlorothiazide, unless it is considered lifesaving for the mother thiazides can cross the placenta, and concentrations reached in the umbilical vein approach those in the maternal plasma use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia the use of hydrochlorothiazide for other indications in pregnancy should be avoided it is not known whether losartan is excreted in human milk, but significant levels of losartan and its active metabolite were shown to be present in rat milk thiazides appear in human milk because of the potential for adverse effects on the nursing infant, a decision should be made whether to discontinue nursing or discontinue the drug Side Effects dizziness upper respiratory infection cough back pain hypotension acute angle-closure glaucoma exacerbation of systemic lupus erythematosus
Losartan Potassium and Hydrochlorothiazide Rx tablet, film coated Macleods Pharmaceuticals Limited	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	9 pregnancy and lactation warnings	7 side effects	Trend: rose 48% over 11 months.
Losartan Potassium and Hydrochlorothiazide® · First marketed 2012 · Label last revised July 21, 2025View full label details → Warnings If you find out you are pregnant, please stop taking losartan potassium and hydrochlorothiazide tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. Make sure to correct any volume or salt depletion before starting losartan potassium and hydrochlorothiazide tablets. Your healthcare provider should regularly check your renal function and potassium levels if you are at risk. Be aware of any clinical signs that may indicate fluid or electrolyte imbalance. Watch for symptoms of acute angle-closure glaucoma. This medication may worsen systemic lupus erythematosus. Pregnancy & Lactation Losartan potassium and hydrochlorothiazide tablets can cause harm to the fetus if you take them while pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase the risk of complications for both the fetus and newborn. If you find out you are pregnant, please stop taking losartan potassium and hydrochlorothiazide tablets as soon as possible. Taking medications that act on the renin-angiotensin system in the second and third trimesters of pregnancy may lead to low amniotic fluid, decreased fetal kidney function resulting in no urine production and kidney failure, underdeveloped lungs, skeletal deformities including skull underdevelopment, low blood pressure, and even death. If low amniotic fluid is detected, you should stop taking losartan potassium and hydrochlorothiazide tablets unless your healthcare provider determines it is essential for your health. Thiazides can cross the placenta, and the levels in the umbilical vein can be similar to those in your bloodstream. Using thiazides during pregnancy may increase the risk of jaundice or low platelet counts in the fetus or newborn. It is advisable to avoid using hydrochlorothiazide for other conditions during pregnancy. Your healthcare provider should closely monitor newborns who were exposed to losartan potassium and hydrochlorothiazide tablets in utero for low blood pressure, reduced urine output, and high potassium levels. Side Effects You may experience dizziness. You could develop an upper respiratory infection. Coughing may occur. You might feel back pain. Be aware of the possibility of hypotension. Your healthcare provider should monitor you for acute angle-closure glaucoma. There may be an exacerbation of systemic lupus erythematosus. Warnings when pregnancy is detected, discontinue losartan potassium and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume or salt depletion prior to administration of losartan potassium and hydrochlorothiazide tablets monitor renal function and potassium in susceptible patients observe for clinical signs of fluid or electrolyte imbalance acute angle-closure glaucoma exacerbation of systemic lupus erythematosus Pregnancy & Lactation losartan potassium and hydrochlorothiazide tablets can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue losartan potassium and hydrochlorothiazide tablets as soon as possible use of drugs that act on the renin-angiotensin system in the second and third trimesters of pregnancy can result in oligohydramnios, reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death if oligohydramnios is observed, discontinue losartan potassium and hydrochlorothiazide tablets, unless it is considered lifesaving for the mother thiazides can cross the placenta, and concentrations reached in the umbilical vein approach those in the maternal plasma use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia the use of hydrochlorothiazide for other indications in pregnancy should be avoided closely observe neonates with histories of in utero exposure to losartan potassium and hydrochlorothiazide tablets for hypotension, oliguria, and hyperkalemia Side Effects dizziness upper respiratory infection cough back pain hypotension acute angle-closure glaucoma exacerbation of systemic lupus erythematosus
Losartan Potassium and Hydrochlorothiazide Rx tablet, film coated Alembic Pharmaceuticals Inc.	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	11 pregnancy and lactation warnings	8 side effects	Trend: rose 48% over 11 months.
Losartan Potassium and Hydrochlorothiazide® · First marketed 2016 · Label last revised December 26, 2025View full label details → Warnings You should stop taking losartan potassium and hydrochlorothiazide tablets as soon as you find out you are pregnant. Medications that directly affect the renin-angiotensin system can harm your developing fetus. Make sure to correct any volume or salt depletion before starting losartan potassium and hydrochlorothiazide tablets. Your healthcare provider will need to monitor your renal function and potassium levels if you are at risk. Be aware of any clinical signs of fluid or electrolyte imbalance. Watch for symptoms of acute angle-closure glaucoma. This medication may worsen systemic lupus erythematosus. Pregnancy & Lactation Losartan potassium and hydrochlorothiazide tablets can cause harm to the fetus if you take them while pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please stop taking losartan potassium and hydrochlorothiazide tablets as soon as possible. High blood pressure during pregnancy raises your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for your baby, including issues like intrauterine growth restriction and intrauterine death. Taking medications that affect the renin-angiotensin system in the second and third trimesters of pregnancy may lead to oligohydramnios, reduced kidney function in the fetus, which can cause anuria and renal failure, fetal lung underdevelopment, skeletal deformities such as skull hypoplasia, low blood pressure, and even death. If oligohydramnios is detected, you should stop taking losartan potassium and hydrochlorothiazide tablets, unless your healthcare provider determines it is essential for your health. Thiazides can cross the placenta, and the levels in the umbilical vein can be similar to those in your bloodstream. Using thiazides during pregnancy may increase the risk of jaundice or low platelet counts in your baby. It's best to avoid using hydrochlorothiazide for other conditions during pregnancy. You should consider whether to stop nursing or discontinue the medication, keeping in mind how important the medication is for your health. Side Effects You may experience dizziness. You might develop an upper respiratory infection. Coughing could occur. You may feel back pain. Watch for signs of hypotension. There could be a fluid or electrolyte imbalance. Your healthcare provider should monitor you for acute angle-closure glaucoma. You may notice an exacerbation of systemic lupus erythematosus. Warnings discontinue losartan potassium and hydrochlorothiazide tablets as soon as possible when pregnancy is detected drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume or salt depletion prior to administration of losartan potassium and hydrochlorothiazide tablets monitor renal function and potassium in susceptible patients observe for clinical signs of fluid or electrolyte imbalance acute angle-closure glaucoma exacerbation of systemic lupus erythematosus Pregnancy & Lactation losartan potassium and hydrochlorothiazide tablets can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue losartan potassium and hydrochlorothiazide tablets as soon as possible hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death use of drugs that act on the renin-angiotensin system in the second and third trimesters of pregnancy can result in oligohydramnios, reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death if oligohydramnios is observed, discontinue losartan potassium and hydrochlorothiazide tablets, unless it is considered lifesaving for the mother thiazides can cross the placenta, and concentrations reached in the umbilical vein approach those in the maternal plasma use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia the use of hydrochlorothiazide for other indications in pregnancy should be avoided a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother Side Effects dizziness upper respiratory infection cough back pain hypotension fluid or electrolyte imbalance acute angle-closure glaucoma exacerbation of systemic lupus erythematosus
Losartan Potassium and Hydrochlorothiazide Rx tablet, film coated Granules Pharmaceuticals Inc.	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	13 pregnancy and lactation warnings	7 side effects	Trend: rose 48% over 11 months.
Losartan Potassium and Hydrochlorothiazide® · First marketed 2023 · Label last revised July 23, 2025View full label details → Warnings If you find out you are pregnant, please stop taking losartan potassium and hydrochlorothiazide tablets as soon as possible. Be aware that medications affecting the renin-angiotensin system can harm the developing fetus and may lead to serious complications. Make sure to correct any volume or salt depletion before starting losartan potassium and hydrochlorothiazide. Your healthcare provider should regularly check your renal function and potassium levels if you are at risk. Keep an eye out for any signs of fluid or electrolyte imbalance. Be cautious of acute angle-closure glaucoma. This medication may worsen systemic lupus erythematosus. Pregnancy & Lactation If you are pregnant, be aware that losartan potassium and hydrochlorothiazide can cause harm to the fetus. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase the risk of complications for both the fetus and newborn. As soon as you find out you are pregnant, please discontinue losartan potassium and hydrochlorothiazide as soon as possible. Hypertension during pregnancy raises your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for your baby, including intrauterine growth restriction and intrauterine death. Taking medications that act on the renin-angiotensin system in the second and third trimesters of pregnancy may lead to oligohydramnios, reduced kidney function in the fetus, anuria, renal failure, underdeveloped lungs, skeletal deformities such as skull hypoplasia, low blood pressure, and even death. If oligohydramnios is detected, you should stop taking losartan potassium and hydrochlorothiazide unless your healthcare provider determines it is essential for your health. Thiazides can cross the placenta, and the levels in the umbilical vein can be similar to those in your bloodstream. Using thiazides during pregnancy may carry a risk of jaundice or low platelet counts in the fetus or newborn. It's best to avoid using hydrochlorothiazide for other conditions during pregnancy. While it is unclear if losartan is present in human milk, significant amounts have been found in rat milk. Thiazides can also appear in human milk. Due to the potential risks to your nursing infant, you should decide whether to continue breastfeeding or to stop taking the medication. Side Effects You may experience dizziness. You could develop an upper respiratory infection. Coughing might occur. You may feel back pain. Watch for signs of hypotension. There is a risk of acute angle-closure glaucoma. You may see an exacerbation of systemic lupus erythematosus. Warnings when pregnancy is detected, discontinue losartan potassium and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume or salt depletion prior to administration of losartan potassium and hydrochlorothiazide monitor renal function and potassium in susceptible patients observe for clinical signs of fluid or electrolyte imbalance acute angle-closure glaucoma exacerbation of systemic lupus erythematosus Pregnancy & Lactation losartan potassium and hydrochlorothiazide can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue losartan potassium and hydrochlorothiazide as soon as possible hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death use of drugs that act on the renin-angiotensin system in the second and third trimesters of pregnancy can result in oligohydramnios, reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death if oligohydramnios is observed, discontinue losartan potassium and hydrochlorothiazide, unless it is considered lifesaving for the mother thiazides can cross the placenta, and concentrations reached in the umbilical vein approach those in the maternal plasma use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia the use of hydrochlorothiazide for other indications in pregnancy should be avoided it is not known whether losartan is excreted in human milk, but significant levels of losartan and its active metabolite were shown to be present in rat milk thiazides appear in human milk because of the potential for adverse effects on the nursing infant, a decision should be made whether to discontinue nursing or discontinue the drug Side Effects dizziness upper respiratory infection cough back pain hypotension acute angle-closure glaucoma exacerbation of systemic lupus erythematosus
Losartan Potassium and Hydrochlorothiazide Rx tablet, film coated Alembic Pharmaceuticals Limited	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	7 pregnancy and lactation warnings	7 side effects	Trend: rose 48% over 11 months.
Losartan Potassium and Hydrochlorothiazide® · First marketed 2016 · Label last revised September 23, 2025View full label details → Warnings If you find out you are pregnant, please stop taking losartan potassium and hydrochlorothiazide tablets as soon as possible. Be aware that medications affecting the renin-angiotensin system can harm the developing fetus and may lead to serious complications. Make sure to correct any volume or salt depletion before starting losartan potassium and hydrochlorothiazide tablets. Your healthcare provider should regularly check your renal function and potassium levels if you are at risk. Keep an eye out for any signs of fluid or electrolyte imbalance. Be cautious of acute angle-closure glaucoma. This medication may worsen systemic lupus erythematosus. Pregnancy & Lactation Using drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal renal function and increase the risk of morbidity and mortality for both the fetus and neonate. If you find out you are pregnant, please discontinue losartan as soon as possible. In the rare case that there is no suitable alternative to therapy with drugs affecting the renin-angiotensin system for your situation, make sure to discuss the potential risks to your fetus with your healthcare provider. If oligohydramnios is observed, your healthcare provider may recommend discontinuing losartan potassium and hydrochlorothiazide tablets, unless it is deemed lifesaving for you. Thiazides can cross the placental barrier and may be found in cord blood. There is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Adverse effects on the fetus and neonate, including decreased body weight, renal toxicity, and mortality, were noted when pregnant rats were treated during late gestation and/or lactation with 50 mg/kg/day losartan in combination with 12.5 mg/kg/day hydrochlorothiazide. Side Effects You may experience dizziness. You could develop an upper respiratory infection. Coughing may occur. You might feel back pain. Be aware of the possibility of hypotension. Your healthcare provider should monitor you for acute angle-closure glaucoma. There may be an exacerbation of systemic lupus erythematosus. Warnings when pregnancy is detected, discontinue losartan potassium and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume or salt depletion prior to administration of losartan potassium and hydrochlorothiazide tablets monitor renal function and potassium in susceptible patients observe for clinical signs of fluid or electrolyte imbalance acute angle-closure glaucoma exacerbation of systemic lupus erythematosus Pregnancy & Lactation use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue losartan as soon as possible in the unusual case that there is no appropriate alternative to therapy with drugs affecting the renin-angiotensin system for a particular patient, apprise the mother of the potential risk to the fetus if oligohydramnios is observed, discontinue losartan potassium and hydrochlorothiazide tablets, unless it is considered lifesaving for the mother thiazides cross the placental barrier and appear in cord blood there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults adverse fetal and neonatal effects, including decreased body weight, renal toxicity, and mortality, occurred when pregnant rats were treated during late gestation and/or lactation with 50 mg/kg/day losartan in combination with 12.5 mg/kg/day hydrochlorothiazide Side Effects dizziness upper respiratory infection cough back pain hypotension acute angle-closure glaucoma exacerbation of systemic lupus erythematosus
Losartan Potassium and Hydrochlorothiazide Rx tablet, film coated Aurobindo Pharma Limited	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	13 pregnancy and lactation warnings	7 side effects	Trend: rose 48% over 11 months.
Losartan Potassium and Hydrochlorothiazide® · First marketed 2010 · Label last revised August 6, 2025View full label details → Warnings If you find out you are pregnant, please stop taking losartan potassium and hydrochlorothiazide tablets as soon as possible. Be aware that medications affecting the renin-angiotensin system can harm the developing fetus and may lead to serious complications. Make sure to correct any volume or salt depletion before starting losartan potassium and hydrochlorothiazide. Your healthcare provider should regularly check your renal function and potassium levels if you are at risk. Keep an eye out for any signs of fluid or electrolyte imbalance. Be cautious of acute angle-closure glaucoma. This medication may worsen systemic lupus erythematosus. Pregnancy & Lactation Losartan potassium and hydrochlorothiazide can cause harm to the fetus if you take them while pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please stop taking losartan potassium and hydrochlorothiazide as soon as possible. High blood pressure during pregnancy raises your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for your baby, including intrauterine growth restriction and intrauterine death. Taking medications that act on the renin-angiotensin system in the second and third trimesters of pregnancy may lead to oligohydramnios, reduced kidney function in the fetus, which can cause anuria and renal failure, fetal lung underdevelopment, skeletal deformities such as skull hypoplasia, low blood pressure, and even death. If oligohydramnios is detected, you should stop taking losartan potassium and hydrochlorothiazide unless your healthcare provider determines it is essential for your health. Thiazides can cross the placenta, and the levels in the umbilical vein can be similar to those in your bloodstream. Using thiazides during pregnancy may increase the risk of jaundice or low platelet counts in your baby. It's best to avoid using hydrochlorothiazide for other conditions during pregnancy. It is unclear if losartan is passed into human milk, but significant amounts of losartan and its active metabolite have been found in rat milk. Thiazides can appear in human milk. Due to the potential risks to your nursing infant, you should decide whether to continue breastfeeding or to stop taking the medication. Side Effects You may experience dizziness. You might develop an upper respiratory infection. Coughing could occur. You may feel back pain. Watch for signs of hypotension. There is a risk of acute angle-closure glaucoma. You may see an exacerbation of systemic lupus erythematosus. Warnings when pregnancy is detected, discontinue losartan potassium and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume or salt depletion prior to administration of losartan potassium and hydrochlorothiazide monitor renal function and potassium in susceptible patients observe for clinical signs of fluid or electrolyte imbalance acute angle-closure glaucoma exacerbation of systemic lupus erythematosus Pregnancy & Lactation losartan potassium and hydrochlorothiazide can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue losartan potassium and hydrochlorothiazide as soon as possible hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death use of drugs that act on the renin-angiotensin system in the second and third trimesters of pregnancy can result in oligohydramnios, reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death if oligohydramnios is observed, discontinue losartan potassium and hydrochlorothiazide, unless it is considered lifesaving for the mother thiazides can cross the placenta, and concentrations reached in the umbilical vein approach those in the maternal plasma use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia the use of hydrochlorothiazide for other indications in pregnancy should be avoided it is not known whether losartan is excreted in human milk, but significant levels of losartan and its active metabolite were shown to be present in rat milk thiazides appear in human milk because of the potential for adverse effects on the nursing infant, a decision should be made whether to discontinue nursing or discontinue the drug Side Effects dizziness upper respiratory infection cough back pain hypotension acute angle-closure glaucoma exacerbation of systemic lupus erythematosus
Losartan Potassium and Hydrochlorothiazide Rx tablet, film coated Teva Pharmaceuticals USA, Inc.	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	10 pregnancy and lactation warnings	8 side effects	Trend: rose 48% over 11 months.
Losartan Potassium and Hydrochlorothiazide® · First marketed 2010 · Label last revised November 1, 2023View full label details → Warnings If you find out you are pregnant, please stop taking losartan potassium and hydrochlorothiazide tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. Make sure to correct any volume or salt depletion before starting losartan potassium and hydrochlorothiazide tablets. Your healthcare provider should regularly check your renal function and potassium levels if you are at risk. Be aware of any clinical signs that may indicate fluid or electrolyte imbalance. Watch for symptoms of acute angle-closure glaucoma. This medication may worsen systemic lupus erythematosus. Pregnancy & Lactation Losartan potassium and hydrochlorothiazide tablets can cause harm to the fetus if you take them while pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please stop taking losartan potassium and hydrochlorothiazide tablets as soon as possible. High blood pressure during pregnancy raises your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for your baby of intrauterine growth restriction and intrauterine death. Taking medications that act on the renin-angiotensin system in the second and third trimesters of pregnancy may lead to oligohydramnios, reduced kidney function in the fetus, which can cause anuria and renal failure, fetal lung underdevelopment, skeletal deformities including skull hypoplasia, low blood pressure, and even death. If oligohydramnios is detected, you should stop taking losartan potassium and hydrochlorothiazide tablets unless your healthcare provider determines it is necessary to save your life. Thiazides can cross the placenta, and the levels in the umbilical vein can be similar to those in your bloodstream. Using thiazides during pregnancy is linked to a risk of jaundice or low platelet counts in your baby. It's best to avoid using hydrochlorothiazide for other conditions during pregnancy. Side Effects You may experience dizziness. You might develop an upper respiratory infection. Coughing could occur. You may feel back pain. Watch for signs of hypotension. There could be a risk of fluid or electrolyte imbalance. Be aware of the possibility of acute angle-closure glaucoma. This medication may worsen systemic lupus erythematosus. Warnings when pregnancy is detected, discontinue losartan potassium and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume or salt depletion prior to administration of losartan potassium and hydrochlorothiazide tablets monitor renal function and potassium in susceptible patients observe for clinical signs of fluid or electrolyte imbalance acute angle-closure glaucoma exacerbation of systemic lupus erythematosus Pregnancy & Lactation losartan potassium and hydrochlorothiazide tablets can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue losartan potassium and hydrochlorothiazide tablets as soon as possible hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death use of drugs that act on the renin-angiotensin system in the second and third trimesters of pregnancy can result in oligohydramnios, reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death if oligohydramnios is observed, discontinue losartan potassium and hydrochlorothiazide tablets, unless it is considered lifesaving for the mother thiazides can cross the placenta, and concentrations reached in the umbilical vein approach those in the maternal plasma use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia the use of hydrochlorothiazide for other indications in pregnancy should be avoided Side Effects dizziness upper respiratory infection cough back pain hypotension fluid or electrolyte imbalance acute angle-closure glaucoma exacerbation of systemic lupus erythematosus
Losartan Potassium and Hydrochlorothiazide Rx tablet, film coated Jubilant Cadista Pharmaceuticals Inc.	Popularity – score 0 out of 100 (least-viewed drug)	6 warnings	10 pregnancy and lactation warnings	8 side effects	Trend: rose 48% over 11 months.
Losartan Potassium and Hydrochlorothiazide® · First marketed 2012 · Label last revised December 5, 2025View full label details → Warnings If you find out you are pregnant, please stop taking losartan potassium and hydrochlorothiazide as soon as possible. Medications that affect the renin-angiotensin system can harm your developing fetus. Make sure to correct any volume or salt depletion before starting losartan potassium and hydrochlorothiazide. Your healthcare provider should monitor your renal function and potassium levels if you are at risk. Be aware of any clinical signs of fluid or electrolyte imbalance. Watch for symptoms of acute angle-closure glaucoma. This medication may worsen systemic lupus erythematosus. Pregnancy & Lactation Losartan potassium and hydrochlorothiazide can cause harm to the fetus if you take them while pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please stop taking losartan potassium and hydrochlorothiazide as soon as possible. Having high blood pressure during pregnancy raises your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for your baby of intrauterine growth restriction and intrauterine death. Taking medications that affect the renin-angiotensin system in the second and third trimesters of pregnancy may lead to oligohydramnios, reduced kidney function in the fetus, which can cause anuria and renal failure, fetal lung underdevelopment, skeletal deformities including skull underdevelopment, low blood pressure, and even death. If oligohydramnios is detected, you should stop taking losartan potassium and hydrochlorothiazide, unless your healthcare provider determines it is essential for your health. Thiazides can cross the placenta, and the levels in the umbilical vein can be similar to those in your bloodstream. Using thiazides during pregnancy may increase the risk of jaundice or low platelet counts in your baby. It's best to avoid using hydrochlorothiazide for other conditions during pregnancy. Side Effects You may experience dizziness. You might develop an upper respiratory infection. Coughing could occur. You may feel back pain. Hypotension is a possibility. Be aware of potential fluid or electrolyte imbalance. There is a risk of acute angle-closure glaucoma. You may see an exacerbation of systemic lupus erythematosus. Warnings when pregnancy is detected, discontinue losartan potassium and hydrochlorothiazide as soon as possible. drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume or salt depletion prior to administration of losartan potassium and hydrochlorothiazide monitor renal function and potassium in susceptible patients observe for clinical signs of fluid or electrolyte imbalance acute angle-closure glaucoma exacerbation of systemic lupus erythematosus Pregnancy & Lactation losartan potassium and hydrochlorothiazide can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue losartan potassium and hydrochlorothiazide as soon as possible hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death use of drugs that act on the renin-angiotensin system in the second and third trimesters of pregnancy can result in oligohydramnios, reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death if oligohydramnios is observed, discontinue losartan potassium and hydrochlorothiazide, unless it is considered lifesaving for the mother thiazides can cross the placenta, and concentrations reached in the umbilical vein approach those in the maternal plasma use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia the use of hydrochlorothiazide for other indications in pregnancy should be avoided Side Effects dizziness upper respiratory infection cough back pain hypotension fluid or electrolyte imbalance acute angle-closure glaucoma exacerbation of systemic lupus erythematosus
Losartan Potassium and Hydrochlorothiazide Rx tablet, film coated AvKARE	Popularity – score 0 out of 100 (least-viewed drug)	6 warnings	10 pregnancy and lactation warnings	8 side effects	Trend: rose 48% over 11 months.
Losartan Potassium and Hydrochlorothiazide® · First marketed 2022 · Label last revised August 28, 2025View full label details → Warnings If you find out you are pregnant, please stop taking losartan potassium and hydrochlorothiazide as soon as possible. Medications that affect the renin-angiotensin system can harm your developing fetus. Make sure to correct any volume or salt depletion before starting losartan potassium and hydrochlorothiazide. Your healthcare provider should monitor your renal function and potassium levels if you are at risk. Be aware of any clinical signs that may indicate fluid or electrolyte imbalance. Watch for symptoms of acute angle-closure glaucoma. This medication may worsen systemic lupus erythematosus. Pregnancy & Lactation Losartan potassium and hydrochlorothiazide can cause harm to the fetus if you take them while pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please stop taking losartan potassium and hydrochlorothiazide as soon as possible. Having high blood pressure during pregnancy raises your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for your baby of intrauterine growth restriction and intrauterine death. Taking medications that act on the renin-angiotensin system in the second and third trimesters of pregnancy may lead to oligohydramnios, reduced kidney function in the fetus, which can cause anuria and renal failure, fetal lung underdevelopment, skeletal deformities including skull hypoplasia, low blood pressure, and even death. If oligohydramnios is detected, you should stop taking losartan potassium and hydrochlorothiazide unless your healthcare provider determines it is necessary to save your life. Thiazides can cross the placenta, and the levels in the umbilical vein can be similar to those in your bloodstream. Using thiazides during pregnancy is linked to a risk of jaundice or low platelet counts in your baby. It's best to avoid using hydrochlorothiazide for other conditions during pregnancy. Side Effects You may experience dizziness. You might develop an upper respiratory infection. Coughing could occur. You may feel back pain. Watch for signs of hypotension. Be aware of potential fluid or electrolyte imbalances. Your healthcare provider should monitor you for acute angle-closure glaucoma. There may be an exacerbation of systemic lupus erythematosus. Warnings when pregnancy is detected, discontinue losartan potassium and hydrochlorothiazide as soon as possible. drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume or salt depletion prior to administration of losartan potassium and hydrochlorothiazide monitor renal function and potassium in susceptible patients observe for clinical signs of fluid or electrolyte imbalance acute angle-closure glaucoma exacerbation of systemic lupus erythematosus Pregnancy & Lactation losartan potassium and hydrochlorothiazide can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue losartan potassium and hydrochlorothiazide as soon as possible hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death use of drugs that act on the renin-angiotensin system in the second and third trimesters of pregnancy can result in oligohydramnios, reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death if oligohydramnios is observed, discontinue losartan potassium and hydrochlorothiazide, unless it is considered lifesaving for the mother thiazides can cross the placenta, and concentrations reached in the umbilical vein approach those in the maternal plasma use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia the use of hydrochlorothiazide for other indications in pregnancy should be avoided Side Effects dizziness upper respiratory infection cough back pain hypotension fluid or electrolyte imbalance acute angle-closure glaucoma exacerbation of systemic lupus erythematosus
Losartan Potassium and Hydrochlorothiazide Rx tablet Lupin Pharmaceuticals, Inc.	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	10 pregnancy and lactation warnings	8 side effects	Trend: rose 48% over 11 months.
Losartan Potassium and Hydrochlorothiazide® · First marketed 2010 · Label last revised November 11, 2025View full label details → Warnings If you find out you are pregnant, please stop taking losartan potassium and hydrochlorothiazide tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm your developing fetus, potentially leading to serious injury or death. Make sure to correct any volume or salt depletion before starting losartan and hydrochlorothiazide. Your healthcare provider should regularly check your renal function and potassium levels if you are at risk. Be aware of any clinical signs that may indicate fluid or electrolyte imbalance. Watch for symptoms of acute angle-closure glaucoma. This medication may worsen systemic lupus erythematosus. Pregnancy & Lactation Losartan and hydrochlorothiazide can cause harm to your fetus if you are pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of your pregnancy may reduce your baby's kidney function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please stop taking losartan and hydrochlorothiazide as soon as possible. High blood pressure during pregnancy raises your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for your baby of intrauterine growth restriction and intrauterine death. Taking medications that act on the renin-angiotensin system in the second and third trimesters of pregnancy can lead to low amniotic fluid, reduced kidney function in your baby, lung development issues, skeletal deformities, low blood pressure, and even death. If low amniotic fluid is detected, you should stop taking losartan and hydrochlorothiazide unless your healthcare provider believes it is essential for your health. Thiazides can cross the placenta, and the levels in the umbilical vein can be similar to those in your bloodstream. Using thiazides during pregnancy may increase the risk of jaundice or low platelet counts in your baby. It's best to avoid using hydrochlorothiazide for other conditions during your pregnancy. Side Effects You may experience dizziness. You might develop an upper respiratory infection. Coughing could occur. You may feel back pain. Hypotension is a possibility. There could be a fluid or electrolyte imbalance. Your healthcare provider should monitor for acute angle-closure glaucoma. Exacerbation of systemic lupus erythematosus may happen. Warnings when pregnancy is detected, discontinue losartan potassium and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume or salt depletion prior to administration of losartan and hydrochlorothiazide monitor renal function and potassium in susceptible patients observe for clinical signs of fluid or electrolyte imbalance acute angle-closure glaucoma exacerbation of systemic lupus erythematosus Pregnancy & Lactation losartan and hydrochlorothiazide can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue losartan and hydrochlorothiazide as soon as possible hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death use of drugs that act on the renin-angiotensin system in the second and third trimesters of pregnancy can result in oligohydramnios, reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death if oligohydramnios is observed, discontinue losartan and hydrochlorothiazide, unless it is considered lifesaving for the mother thiazides can cross the placenta, and concentrations reached in the umbilical vein approach those in the maternal plasma use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia the use of hydrochlorothiazide for other indications in pregnancy should be avoided Side Effects dizziness upper respiratory infection cough back pain hypotension fluid or electrolyte imbalance acute angle-closure glaucoma exacerbation of systemic lupus erythematosus
Losartan Potassium and Hydrochlorothiazide Rx tablet, film coated Unichem Pharmaceuticals (USA) , Inc.	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	0 pregnancy and lactation warnings	8 side effects	Trend: rose 48% over 11 months.
Losartan Potassium and Hydrochlorothiazide® · First marketed 2017 · Label last revised July 1, 2025View full label details → Warnings If you find out you are pregnant, please stop taking losartan potassium and hydrochlorothiazide tablets as soon as possible. Be aware that medications affecting the renin-angiotensin system can harm the developing fetus and may lead to serious complications. Make sure to correct any volume or salt depletion before starting losartan potassium and hydrochlorothiazide tablets. Your healthcare provider should regularly check your renal function and potassium levels if you are at risk. Keep an eye out for any signs of fluid or electrolyte imbalance. Be cautious of acute angle-closure glaucoma. This medication may worsen systemic lupus erythematosus. Pregnancy & Lactation Losartan potassium and hydrochlorothiazide tablets can cause harm to the fetus if you take them while pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please stop taking losartan potassium and hydrochlorothiazide tablets as soon as possible. High blood pressure during pregnancy raises your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for your baby, including issues like intrauterine growth restriction and intrauterine death. Taking medications that act on the renin-angiotensin system in the second and third trimesters of pregnancy may lead to oligohydramnios, reduced kidney function in the fetus, fetal lung development issues, skeletal deformities, low blood pressure, and even death. If oligohydramnios is detected, you should stop taking losartan potassium and hydrochlorothiazide tablets unless your healthcare provider determines it is necessary for your health. Thiazides can cross the placenta, and the levels in the umbilical vein can be similar to those in your bloodstream. Using thiazides during pregnancy may increase the risk of jaundice or low platelet counts in your baby. It's best to avoid using hydrochlorothiazide for other conditions during pregnancy. It is unclear if losartan passes into human breast milk, but significant amounts have been found in rat milk. Thiazides do appear in human milk. Due to the potential risks to your nursing infant, you should decide whether to continue breastfeeding or to stop taking the medication. Side Effects You may experience dizziness. You might develop an upper respiratory infection. Coughing could occur. You may feel back pain. Watch for signs of hypotension. There could be a fluid or electrolyte imbalance. Your healthcare provider should monitor you for acute angle-closure glaucoma. You may notice an exacerbation of systemic lupus erythematosus. Warnings when pregnancy is detected, discontinue losartan potassium and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume or salt depletion prior to administration of losartan potassium and hydrochlorothiazide tablets monitor renal function and potassium in susceptible patients observe for clinical signs of fluid or electrolyte imbalance acute angle-closure glaucoma exacerbation of systemic lupus erythematosus Pregnancy & Lactation No pregnancy & lactation warnings reported. Side Effects dizziness upper respiratory infection cough back pain hypotension fluid or electrolyte imbalance acute angle-closure glaucoma exacerbation of systemic lupus erythematosus
Losartan Potassium and Hydrochlorothiazide Rx tablet, film coated REMEDYREPACK INC.	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	0 pregnancy and lactation warnings	7 side effects	Trend: rose 48% over 11 months.
Losartan Potassium and Hydrochlorothiazide® · First marketed 2022 · Label last revised July 22, 2025View full label details → Warnings If you find out you are pregnant, please stop taking losartan potassium and hydrochlorothiazide tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. Make sure to correct any volume or salt depletion before starting losartan potassium and hydrochlorothiazide tablets. Your healthcare provider should regularly check your renal function and potassium levels if you are at risk. Be aware of any clinical signs that may indicate fluid or electrolyte imbalance. Watch for symptoms of acute angle-closure glaucoma. This medication may worsen systemic lupus erythematosus. Pregnancy & Lactation No pregnancy & lactation warnings reported. Side Effects You may experience dizziness. You could develop an upper respiratory infection. Coughing may occur. You might feel back pain. Be aware of the possibility of hypotension. Your healthcare provider should monitor you for acute angle-closure glaucoma. There may be an exacerbation of systemic lupus erythematosus. Warnings when pregnancy is detected, discontinue losartan potassium and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume or salt depletion prior to administration of losartan potassium and hydrochlorothiazide tablets monitor renal function and potassium in susceptible patients observe for clinical signs of fluid or electrolyte imbalance acute angle-closure glaucoma exacerbation of systemic lupus erythematosus Pregnancy & Lactation No pregnancy & lactation warnings reported. Side Effects dizziness upper respiratory infection cough back pain hypotension acute angle-closure glaucoma exacerbation of systemic lupus erythematosus
Lotensin Hct (benazepril hydrochloride and hydrochlorothiazide) Rx tablet Validus Pharmaceuticals LLC	Popularity – score 0 out of 100 (least-viewed drug)	20 warnings	1 pregnancy and lactation warnings	70 side effects	Trend: rose 50% over 11 months; bumpy overall.
Lotensin Hct® · First marketed 1992 · Label last revised September 30, 2025View full label details → Warnings If you find out you are pregnant, please stop taking Lotensin HCT as soon as possible. Angioedema, including swelling of the throat, can happen at any time while you are being treated with ACE inhibitors. If you are taking Lotensin HCT, please report any signs or symptoms of angioedema immediately, such as swelling of your face, eyes, lips, or tongue, or any difficulty in breathing. If you are a female of childbearing age, it's important to understand the risks of using Lotensin HCT during pregnancy. Please inform your physician about any pregnancies as soon as possible. Be aware that lightheadedness can occur, especially during the first few days of your therapy with Lotensin HCT. If you experience fainting, please stop taking Lotensin HCT and consult your physician. Inadequate fluid intake, excessive sweating, diarrhea, or vomiting can lead to a significant drop in your blood pressure. Do not use potassium supplements or salt substitutes containing potassium without first consulting your prescribing physician. Please report any signs of infection, such as a sore throat or fever, promptly, as these could indicate neutropenia. If you are taking hydrochlorothiazide, remember to protect your skin from the sun and have regular skin cancer screenings. Your healthcare provider will monitor your renal function periodically while you are treated with Lotensin HCT. If you experience a significant decrease in renal function while on Lotensin HCT, your healthcare provider may consider withholding or discontinuing your therapy. If you are taking both an ACE inhibitor and an mTOR inhibitor, you may be at a higher risk for angioedema. If you are taking neprilysin inhibitors alongside your medication, you may also be at increased risk for angioedema. Your healthcare provider will monitor your potassium levels periodically while you are on Lotensin HCT. If you are receiving benazepril and NSAID therapy, your renal function will be monitored periodically by your healthcare provider. If you develop jaundice or significant elevations in liver enzymes while on an ACE inhibitor, please discontinue the medication and seek appropriate medical follow-up. If you experience low urine output or low blood pressure, focus on supporting your blood pressure and renal function. The safety and effectiveness of this medication in children have not been established. Pregnancy & Lactation You should decide whether to continue nursing or to stop taking Lotensin HCT, considering how important the medication is for you. Side Effects You may experience a cough (1.0%). Dizziness may occur in 1.0% of cases. You might have a headache (0.6%). Fatigue could affect you (0.6%). Dizziness has been reported in 6.3% of patients. Fatigue has been noted in 5.2% of patients. Postural dizziness may occur in 3.5% of patients. Headaches have been reported in 3.1% of patients. Coughing has been noted in 2.1% of patients. Hypertonia may affect 1.5% of patients. You might experience vertigo (1.5%). Nausea could occur in 1.4% of patients. Impotence has been reported in 1.2% of patients. Somnolence may affect 1.2% of patients. You may notice palpitations. Flushing could occur. Vomiting may happen. Diarrhea might affect you. Dyspepsia could occur. You may experience anorexia. Constipation might be an issue. Insomnia could affect you. You might feel nervousness. Paresthesia may occur. You may notice a decrease in libido. Dry mouth could be a side effect. Taste perversion might happen. You may experience tinnitus. A rash could develop. Sweating may occur. You might notice urinary frequency. Arthralgia could affect you. Myalgia may occur. You might feel asthenia. Pain, including chest pain and abdominal pain, could occur. Syncope may happen. You might experience a peripheral vascular disorder. Tachycardia could occur. Infection may affect you. You might have back pain. Flu syndrome could occur. You may experience fever. Chills might affect you. Neck pain could occur. Photosensitivity may happen. You might notice pruritus. Gastroenteritis could affect you. Flatulence may occur. You might have a tooth disorder. Hypesthesia could be a side effect. You may experience abnormal vision. Abnormal dreams might occur. A retinal disorder could affect you. You might have an upper respiratory infection. Epistaxis may occur. Bronchitis could affect you. Rhinitis might happen. Sinusitis may occur. You might notice voice alteration. Conjunctivitis could affect you. Arthritis may occur. You might have a urinary tract infection. Alopecia could be a side effect. Acute renal failure may occur. Anaphylactoid reactions could happen. You might experience angioedema of the face, extremities, lips, tongue, glottis, and larynx. Intestinal angioedema may occur. Acute transient myopia could affect you. Acute angle-closure glaucoma may occur. You might experience exacerbation or activation of systemic lupus erythematosus. Warnings when pregnancy is detected, discontinue Lotensin HCT as soon as possible angioedema, including laryngeal edema, can occur at any time with treatment with ACE inhibitors a patient receiving Lotensin HCT should be told to report immediately any signs or symptoms suggesting angioedema (swelling of face, eyes, lips, or tongue, or difficulty in breathing) female patients of childbearing age should be told about the consequences of exposure to Lotensin HCT during pregnancy patients should be asked to report pregnancies to their physicians as soon as possible a patient receiving Lotensin HCT should be cautioned that lightheadedness can occur, especially during the first days of therapy if syncope occurs, Lotensin HCT should be discontinued until the physician has been consulted inadequate fluid intake, excessive perspiration, diarrhea, or vomiting can lead to an excessive fall in blood pressure a patient receiving Lotensin HCT should be told not to use potassium supplements or salt substitutes containing potassium without consulting the prescribing physician patients should be told to promptly report any indication of infection (e.g., sore throat, fever), which could be a sign of neutropenia instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening monitor renal function periodically in patients treated with Lotensin HCT consider withholding or discontinuing therapy in patients who develop a clinically significant decrease in renal function on Lotensin HCT patients receiving coadministration of ACE inhibitor and mTOR inhibitor may be at increased risk for angioedema patients taking concomitant neprilysin inhibitors may be at increased risk for angioedema monitor potassium periodically in patients receiving Lotensin HCT monitor renal function periodically in patients receiving benazepril and NSAID therapy patients receiving ACE inhibitors who develop jaundice or marked elevations of hepatic enzymes should discontinue the ACE inhibitor and receive appropriate medical follow-up if oliguria or hypotension occurs, direct attention toward support of blood pressure and renal perfusion safety and effectiveness in pediatric patients have not been established Pregnancy & Lactation a decision should be made whether to discontinue nursing or to discontinue Lotensin HCT, taking into account the importance of the drug to the mother Side Effects cough (1.0%) dizziness (1.0%) headache (0.6%) fatigue (0.6%) dizziness in 6.3% of patients fatigue in 5.2% of patients postural dizziness in 3.5% of patients headache in 3.1% of patients cough in 2.1% of patients hypertonia in 1.5% of patients vertigo in 1.5% of patients nausea in 1.4% of patients impotence in 1.2% of patients somnolence in 1.2% of patients palpitations flushing vomiting diarrhea dyspepsia anorexia constipation insomnia nervousness paresthesia libido decrease dry mouth taste perversion tinnitus rash sweating urinary frequency arthralgia myalgia asthenia pain (including chest pain and abdominal pain) syncope peripheral vascular disorder tachycardia infection back pain flu syndrome fever chills neck pain photosensitivity pruritus gastroenteritis flatulence tooth disorder hypesthesia abnormal vision abnormal dreams retinal disorder upper respiratory infection epistaxis bronchitis rhinitis sinusitis voice alteration conjunctivitis arthritis urinary tract infection alopecia acute renal failure anaphylactoid reactions angioedema of the face, extremities, lips, tongue, glottis, and larynx intestinal angioedema acute transient myopia acute angle-closure glaucoma exacerbation or activation of systemic lupus erythematosus
Metoprolol Tartrate and Hydrochlorothiazide Rx tablet Alembic Pharmaceuticals Inc.	Popularity – score 0 out of 100 (least-viewed drug)	11 warnings	9 pregnancy and lactation warnings	8 side effects	Trend: was flat over 11 months; peaks in May, Jul.
Metoprolol Tartrate and Hydrochlorothiazide® · First marketed 2015 · Label last revised January 4, 2024View full label details → Warnings Stopping suddenly may worsen your myocardial ischemia. This medication may make your congestive heart failure worse. You should avoid using beta-blockers. Be aware of bradycardia. Do not stop your therapy before major surgery. This medication may hide symptoms of hypoglycemia and change your glucose levels, so it's important to monitor them. Your healthcare provider should periodically check your serum electrolytes and creatinine levels. This medication can worsen symptoms of arterial insufficiency. Start your therapy with an alpha blocker first. Abruptly stopping in cases of thyrotoxicosis could trigger a thyroid storm. You may not respond to the usual doses of epinephrine for treating allergic reactions. Pregnancy & Lactation If you have untreated hypertension during pregnancy, it can lead to adverse outcomes for both you and your baby. There are inconsistent reports of intrauterine growth restriction, preterm birth, and perinatal mortality associated with the use of beta blockers, including metoprolol, during pregnancy. Rare cases of jaundice, thrombocytopenia, and electrolyte imbalances have been reported in infants exposed to thiazide medications during pregnancy. If you are receiving metoprolol during pregnancy, your newborn may be at risk for hypotension, hypoglycemia, bradycardia, and respiratory depression. Your healthcare provider should observe your newborn for symptoms of hypotension, bradycardia, hypoglycemia, and respiratory depression and manage them accordingly. Hypertension during pregnancy increases your risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications. Hypertension can also increase the risk for your baby of intrauterine growth restriction and intrauterine death. Keep an eye on your breastfed infant for signs of drowsiness or poor feeding. Doses of hydrochlorothiazide that lead to significant diuresis may affect your milk production. Side Effects Stopping suddenly may worsen your myocardial ischemia. This medication may make your congestive heart failure worse. If you have bronchospasm, it's best to avoid beta-blockers. You may experience bradycardia. This medication can mask symptoms of hypoglycemia and change your glucose levels, so be sure to monitor them. It may aggravate symptoms of arterial insufficiency. If you stop taking this medication abruptly while having thyrotoxicosis, it could trigger a thyroid storm. You might not respond to the usual doses of epinephrine used for treating allergic reactions. Warnings abrupt cessation may exacerbate myocardial ischemia may worsen congestive heart failure avoid beta-blockers bradycardia avoid discontinuing therapy prior to major surgery may mask symptoms of hypoglycemia and alter glucose levels; monitor monitor serum electrolytes and creatinine periodically can aggravate symptoms of arterial insufficiency first initiate therapy with an alpha blocker abrupt withdrawal in thyrotoxicosis might precipitate a thyroid storm patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction Pregnancy & Lactation untreated hypertension during pregnancy can lead to adverse outcomes for the mother and the fetus there are inconsistent reports of intrauterine growth restriction, preterm birth, and perinatal mortality with maternal use of beta blockers, including metoprolol, during pregnancy there have been rare reports of jaundice, thrombocytopenia, and electrolyte imbalances in infants exposed to thiazide medications during pregnancy neonates born to mothers who are receiving metoprolol during pregnancy may be at risk for hypotension, hypoglycemia, bradycardia, and respiratory depression observe neonates for symptoms of hypotension, bradycardia, hypoglycemia and respiratory depression and manage accordingly hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death monitor the breastfed infant for drowsiness or poor feeding doses of hydrochlorothiazide associated with clinically significant diuresis have been associated with impaired milk production Side Effects abrupt cessation may exacerbate myocardial ischemia may worsen congestive heart failure bronchospasm: avoid beta-blockers bradycardia may mask symptoms of hypoglycemia and alter glucose levels; monitor can aggravate symptoms of arterial insufficiency abrupt withdrawal in thyrotoxicosis might precipitate a thyroid storm patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction
Metoprolol Tartrate and Hydrochlorothiazide Rx tablet Alembic Pharmaceuticals Limited	Popularity – score 0 out of 100 (least-viewed drug)	35 warnings	3 pregnancy and lactation warnings	101 side effects	Trend: was flat over 11 months; peaks in May, Jul.
Metoprolol Tartrate and Hydrochlorothiazide® · First marketed 2013 · Label last revised January 17, 2023View full label details → Warnings You should use metoprolol cautiously if you have high blood pressure and congestive heart failure that is managed with digitalis and diuretics. At the first sign or symptom of potential cardiac failure, you should be fully digitalized and/or given a diuretic. If cardiac failure persists despite adequate digitalization and diuretic therapy, your healthcare provider may recommend stopping metoprolol. Do not stop taking metoprolol abruptly; please consult your physician before making any changes to your therapy. If you have bronchospastic diseases, you generally should not take beta blockers. Metoprolol may be used cautiously if you have bronchospastic disease and do not respond to or cannot tolerate other antihypertensive treatments. It’s advisable to start with smaller doses of metoprolol three times daily rather than larger doses two times daily. If you are on chronic beta-blocking therapy, it should not be routinely stopped before major surgery. Use metoprolol with caution if you are diabetic and require a beta-blocking agent. If you are suspected of developing thyrotoxicosis, your healthcare provider should manage your treatment carefully to avoid stopping beta blockade suddenly. Thiazides should be used cautiously if you have severe renal disease. Thiazides should also be used with caution if you have impaired liver function or progressive liver disease. If you have a history of allergy or bronchial asthma, you may be more likely to experience sensitivity reactions. There have been reports of exacerbation or activation of systemic lupus erythematosus. Hydrochlorothiazide can cause an unusual reaction, leading to acute transient myopia and acute angle-closure glaucoma. You should not stop taking metoprolol tartrate and hydrochlorothiazide tablets without consulting your physician. Avoid driving or operating machinery until you know how the therapy affects you, as it may impact your alertness. Contact your physician if you experience any difficulty in breathing. Inform your physician or dentist before any type of surgery that you are taking metoprolol tartrate and hydrochlorothiazide tablets. If you notice progressive renal impairment, your healthcare provider may consider withholding or discontinuing diuretic therapy. Hypokalemia may develop, especially if you are experiencing brisk diuresis or severe cirrhosis. You can avoid or treat hypokalemia by using potassium supplements or consuming foods high in potassium. Latent diabetes may become apparent during thiazide treatment. If you are treated with metoprolol and a catecholamine depletor, you should be closely monitored for signs of hypotension or marked bradycardia. While taking beta blockers, if you have a history of severe anaphylactic reactions, you may be more reactive to repeated challenges. If you are taking clonidine and metoprolol together, metoprolol should be stopped several days before you withdraw clonidine. Hypokalemia can make your heart more sensitive to the toxic effects of digitalis. Your insulin requirements may increase, decrease, or remain unchanged if you are diabetic. Thiazides may reduce your arterial responsiveness to norepinephrine, but not enough to affect the effectiveness of the pressor agent for therapeutic use. Thiazides may increase your responsiveness to tubocurarine. Thiazides can reduce lithium renal clearance, increasing the risk of lithium toxicity. There have been rare reports of hemolytic anemia occurring with the combined use of hydrochlorothiazide and methyldopa. Taking some nonsteroidal anti-inflammatory agents concurrently may reduce the diuretic, natriuretic, and antihypertensive effects of thiazide diuretics. Thiazides should be stopped before tests for parathyroid function are conducted. There is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been reported in adults. Pregnancy & Lactation If you find that using metoprolol tartrate and hydrochlorothiazide tablets is essential, you should stop nursing. You should use metoprolol tartrate and hydrochlorothiazide tablets during pregnancy only if the potential benefits outweigh the potential risks to your fetus. Thiazides can cross the placental barrier and may appear in cord blood, which carries a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Side Effects You may experience fatigue or lethargy in about 10 out of 100 patients. You might notice flu-like symptoms in about 10 out of 100 patients. Dizziness or vertigo can occur in about 10 out of 100 patients. Drowsiness or somnolence may affect about 10 out of 100 patients. Headaches are reported in about 10 out of 100 patients. Nightmares can happen in 1 out of 100 patients. Bradycardia may occur in about 6 out of 100 patients. You might have decreased exercise tolerance in about 1 out of 100 patients. Dyspnea can affect about 1 out of 100 patients. Diarrhea may occur in about 1 out of 100 patients. You might experience a digestive disorder in about 1 out of 100 patients. Dry mouth can happen in about 1 out of 100 patients. Nausea or vomiting may affect about 1 out of 100 patients. Constipation can occur in about 1 out of 100 patients. Hypokalemia is seen in fewer than 10 out of 100 patients. Edema may affect 1 out of 100 patients. Gout can occur in 1 out of 100 patients. You might experience anorexia in 1 out of 100 patients. Blurred vision can happen in 1 out of 100 patients. Tinnitus may affect 1 out of 100 patients. Earache can occur in 1 out of 100 patients. You might notice increased sweating in 1 out of 100 patients. Purpura can happen in 1 out of 100 patients. Impotence may affect 1 out of 100 patients. Muscle pain can occur in 1 out of 100 patients. Tiredness is reported in about 10 out of 100 patients. Depression may affect about 5 out of 100 patients. You might experience mental confusion. Short-term memory loss can occur. Headaches may happen. Nightmares can occur. Insomnia might affect you. Shortness of breath is reported in approximately 3 out of 100 patients. You may notice cold extremities. Arterial insufficiency, usually of the Raynaud type, can occur. Palpitations may affect you. Congestive heart failure is a possibility. Gangrene may occur very rarely in patients with pre-existing severe peripheral circulatory disorders. Wheezing (bronchospasm) is seen in fewer than 1 out of 100 patients. Rhinitis may affect you. Nausea can occur in 1 out of 100 patients or fewer. Gastric pain may happen in 1 out of 100 patients or fewer. Flatulence can occur in 1 out of 100 patients or fewer. Heartburn may affect you in 1 out of 100 patients or fewer. Vomiting can happen. Pruritus is seen in fewer than 1 out of 100 patients. You might develop a rash. Photosensitivity occurs very rarely. Worsening of psoriasis may happen very rarely. Peyronie’s disease is reported in fewer than 1 out of 100,000 patients. Alopecia can occur. Weight gain is very rare. Arthritis may happen very rarely. Retroperitoneal fibrosis is very rare. Reversible mental depression progressing to catatonia can occur. You might experience visual disturbances. Hallucinations may happen. An acute reversible syndrome characterized by disorientation for time and place can occur. Emotional lability may affect you. You might notice a slightly clouded sensorium. Decreased performance on neuropsychometric tests can happen. Intensification of AV block may occur. Agranulocytosis is a possibility. Nonthrombocytopenic purpura may happen. Thrombocytopenic purpura can occur. Fever combined with aching and a sore throat may affect you. Laryngospasm is a possibility. Respiratory distress can occur. Pancreatitis may happen. Jaundice (intrahepatic cholestatic) can occur. Sialadenitis may affect you. Vomiting can happen. Diarrhea may occur. Cramping can affect you. Nausea may happen. Gastric irritation is a possibility. Constipation can occur. Anorexia may affect you. Orthostatic hypotension is a possibility. Vertigo may happen. Dizziness can occur. Transient blurred vision may affect you. Headaches can happen. Paresthesia may occur. Xanthopsia is a possibility. You might experience weakness. Restlessness can occur. Muscle spasms may affect you. Aplastic anemia is a possibility. Leukopenia may happen. Thrombocytopenia can occur. Hyperglycemia is a possibility. Glycosuria may affect you. Hyperuricemia can occur. Necrotizing angiitis is very rare. Stevens-Johnson syndrome may happen. Respiratory distress, including pneumonitis and pulmonary edema, can occur. Purpura may affect you. Urticaria can happen. You might develop a rash. Photosensitivity is a possibility. Warnings metoprolol should be administered cautiously in hypertensive patients who have congestive heart failure controlled by digitalis and diuretics at the first sign or symptom of impending cardiac failure, patients should be fully digitalized and/or given a diuretic if cardiac failure continues, despite adequate digitalization and diuretic therapy, metoprolol should be withdrawn metoprolol should not be withdrawn abruptly, and patients should be cautioned against interruption of therapy without the physician’s advice patients with bronchospastic diseases should, in general, not receive beta blockers metoprolol may be used with caution in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment it would be prudent initially to administer metoprolol in smaller doses three times daily, instead of larger doses two times daily chronically administered beta-blocking therapy should not be routinely withdrawn prior to major surgery metoprolol should be used with caution in diabetic patients if a beta-blocking agent is required patients suspected of developing thyrotoxicosis should be managed carefully to avoid abrupt withdrawal of beta blockade thiazides should be used with caution in patients with severe renal disease thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease sensitivity reactions are more likely to occur in patients with a history of allergy or bronchial asthma the possibility of exacerbation or activation of systemic lupus erythematosus has been reported hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma patients should not discontinue metoprolol tartrate and hydrochlorothiazide tablets without consulting the physician patients should avoid operating automobiles and machinery or engaging in other tasks requiring alertness until the patient’s response to therapy has been determined patients should contact the physician if any difficulty in breathing occurs patients should inform the physician or dentist before any type of surgery that he or she is taking metoprolol tartrate and hydrochlorothiazide tablets if progressive renal impairment becomes evident, withholding or discontinuing diuretic therapy should be considered hypokalemia may develop, especially in cases of brisk diuresis or severe cirrhosis hypokalemia may be avoided or treated by the use of potassium supplements or foods with high potassium content latent diabetes may become manifest during thiazide administration patients treated with metoprolol plus a catecholamine depletor should therefore be closely observed for evidence of hypotension or marked bradycardia while taking beta blockers, patients with a history of severe anaphylactic reaction may be more reactive to repeated challenge if a patient is treated with clonidine and metoprolol concurrently, metoprolol should be stopped several days before clonidine is withdrawn hypokalemia can sensitize or exaggerate the response of the heart to the toxic effects of digitalis insulin requirements in diabetic patients may be increased, decreased, or unchanged thiazides may decrease arterial responsiveness to norepinephrine, but not enough to preclude effectiveness of the pressor agent for therapeutic use thiazides may increase the responsiveness to tubocurarine lithium renal clearance is reduced by thiazides, increasing the risk of lithium toxicity there have been rare reports of hemolytic anemia occurring with the concomitant use of hydrochlorothiazide and methyldopa concurrent administration of some nonsteroidal anti-inflammatory agents may reduce the diuretic, natriuretic and antihypertensive effects of thiazide diuretics thiazides should be discontinued before tests for parathyroid function are made there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults Pregnancy & Lactation if the use of metoprolol tartrate and hydrochlorothiazide tablets is deemed essential, the patient should stop nursing metoprolol tartrate and hydrochlorothiazide tablets should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus thiazides cross the placental barrier and appear in cord blood, and there is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults Side Effects fatigue or lethargy in about 10 in 100 patients flu syndrome in about 10 in 100 patients dizziness or vertigo in about 10 in 100 patients drowsiness or somnolence in about 10 in 100 patients headache in about 10 in 100 patients nightmare in 1 in 100 patients bradycardia in about 6 in 100 patients decreased exercise tolerance in about 1 of 100 patients dyspnea in about 1 of 100 patients diarrhea in about 1 in 100 patients digestive disorder in about 1 in 100 patients dry mouth in about 1 in 100 patients nausea or vomiting in about 1 in 100 patients constipation in about 1 in 100 patients hypokalemia in fewer than 10 in 100 patients edema in 1 in 100 patients gout in 1 in 100 patients anorexia in 1 in 100 patients blurred vision in 1 in 100 patients tinnitus in 1 in 100 patients earache in 1 in 100 patients sweating in 1 in 100 patients purpura in 1 in 100 patients impotence in 1 in 100 patients muscle pain in 1 in 100 patients tiredness in about 10 of 100 patients depression in about 5 of 100 patients mental confusion short-term memory loss headache nightmares insomnia shortness of breath in approximately 3 of 100 patients cold extremities arterial insufficiency, usually of the Raynaud type palpitations congestive heart failure gangrene in patients with pre-existing severe peripheral circulatory disorders very rarely wheezing (bronchospasm) in fewer than 1 of 100 patients rhinitis nausea in 1 of 100 patients or fewer gastric pain in 1 of 100 patients or fewer flatulence in 1 of 100 patients or fewer heartburn in 1 of 100 patients or fewer vomiting pruritus in fewer than 1 of 100 patients rash photosensitivity very rarely worsening of psoriasis very rarely Peyronie’s disease in fewer than 1 of 100,000 patients alopecia weight gain very rarely arthritis very rarely retroperitoneal fibrosis very rarely reversible mental depression progressing to catatonia visual disturbances hallucinations acute reversible syndrome characterized by disorientation for time and place emotional lability slightly clouded sensorium decreased performance on neuropsychometrics intensification of AV block agranulocytosis nonthrombocytopenic purpura thrombocytopenic purpura fever combined with aching and sore throat laryngospasm respiratory distress pancreatitis jaundice (intrahepatic cholestatic) sialadenitis vomiting diarrhea cramping nausea gastric irritation constipation anorexia orthostatic hypotension vertigo dizziness transient blurred vision headache paresthesia xanthopsia weakness restlessness muscle spasm aplastic anemia leukopenia thrombocytopenia hyperglycemia glycosuria hyperuricemia necrotizing angiitis Stevens-Johnson syndrome respiratory distress including pneumonitis and pulmonary edema purpura urticaria rash photosensitivity
Metoprolol Tartrate and Hydrochlorothiazide Rx tablet Ajanta Pharma USA Inc.	Popularity – score 0 out of 100 (least-viewed drug)	11 warnings	8 pregnancy and lactation warnings	8 side effects	Trend: was flat over 11 months; peaks in May, Jul.
Metoprolol Tartrate and Hydrochlorothiazide® · First marketed 2025 · Label last revised January 22, 2025View full label details → Warnings Stopping suddenly may worsen your myocardial ischemia. This medication may make your congestive heart failure worse. If you have bronchospasm, it's best to avoid beta-blockers. You may experience bradycardia. Please do not stop your therapy before major surgery. If you have diabetes, this medication may mask symptoms of hypoglycemia and affect your glucose levels; be sure to monitor them. Your healthcare provider should periodically check your serum electrolytes and creatinine. If you have peripheral vascular disease, this medication can aggravate symptoms of arterial insufficiency. If you have pheochromocytoma, your healthcare provider should first start therapy with an alpha blocker. Abrupt withdrawal during thyrotoxicosis could trigger a thyroid storm. You may not respond to the usual doses of epinephrine used for allergic reactions. Pregnancy & Lactation If you have untreated hypertension during pregnancy, it can lead to adverse outcomes for both you and your fetus. There are inconsistent reports of intrauterine growth restriction, preterm birth, and perinatal mortality associated with maternal use of beta blockers, including metoprolol, during pregnancy. Rare cases have been reported of jaundice, thrombocytopenia, and electrolyte imbalances in infants exposed to thiazide medications during pregnancy. Having hypertension during pregnancy increases your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. Hypertension can also increase the risk for your fetus, including intrauterine growth restriction and intrauterine death. Neonates born to mothers taking metoprolol during pregnancy may be at risk for hypotension, hypoglycemia, bradycardia, and respiratory depression. You should observe neonates for symptoms of hypotension, bradycardia, hypoglycemia, and respiratory depression, and manage them accordingly. A study showed that a 200/50 mg/kg/day combination of metoprolol tartrate and hydrochlorothiazide administered to rats from mid to late gestation through lactation resulted in increased post-implantation loss and decreased neonatal survival. Side Effects If you stop taking this medication suddenly, it may worsen your myocardial ischemia. This medication may make your congestive heart failure worse. If you have bronchospasm, it's best to avoid beta-blockers. You may experience bradycardia. If you have diabetes, this medication may mask symptoms of hypoglycemia and change your glucose levels, so be sure to monitor them. If you have peripheral vascular disease, this medication can aggravate symptoms of arterial insufficiency. If you suddenly withdraw from this medication while experiencing thyrotoxicosis, it could trigger a thyroid storm. You may not respond to the usual doses of epinephrine used to treat allergic reactions. Warnings abrupt cessation may exacerbate myocardial ischemia may worsen congestive heart failure bronchospasm: avoid beta-blockers bradycardia avoid discontinuing therapy prior to major surgery diabetes: may mask symptoms of hypoglycemia and alter glucose levels; monitor monitor serum electrolytes and creatinine periodically peripheral vascular disease: can aggravate symptoms of arterial insufficiency pheochromocytoma: first initiate therapy with an alpha blocker abrupt withdrawal in thyrotoxicosis might precipitate a thyroid storm patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction Pregnancy & Lactation untreated hypertension during pregnancy can lead to adverse outcomes for the mother and the fetus there are inconsistent reports of intrauterine growth restriction, preterm birth, and perinatal mortality with maternal use of beta blockers, including metoprolol, during pregnancy there have been rare reports of jaundice, thrombocytopenia, and electrolyte imbalances in infants exposed to thiazide medications during pregnancy hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death neonates born to mothers who are receiving metoprolol during pregnancy may be at risk for hypotension, hypoglycemia, bradycardia, and respiratory depression observe neonates for symptoms of hypotension, bradycardia, hypoglycemia and respiratory depression and manage accordingly a 200/50 mg/kg/day metoprolol tartrate/hydrochlorothiazide combination administered to rats from mid-late gestation through lactation produced increased post-implantation loss and decreased neonatal survival Side Effects abrupt cessation may exacerbate myocardial ischemia may worsen congestive heart failure bronchospasm: avoid beta-blockers bradycardia diabetes: may mask symptoms of hypoglycemia and alter glucose levels; monitor peripheral vascular disease: can aggravate symptoms of arterial insufficiency abrupt withdrawal in thyrotoxicosis might precipitate a thyroid storm patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction
Metoprolol Tartrate and Hydrochlorothiazide Rx tablet Mylan Pharmaceuticals Inc.	Popularity – score 0 out of 100 (least-viewed drug)	11 warnings	6 pregnancy and lactation warnings	8 side effects	Trend: was flat over 11 months; peaks in May, Jul.
Metoprolol Tartrate and Hydrochlorothiazide® · First marketed 2004 · Label last revised January 15, 2024View full label details → Warnings Stopping suddenly may worsen your myocardial ischemia. This medication may make your congestive heart failure worse. If you have bronchospasm, it's best to avoid beta-blockers. You may experience bradycardia. Please do not stop your therapy before major surgery. If you have diabetes, this medication may mask symptoms of hypoglycemia and affect your glucose levels; be sure to monitor them. Your healthcare provider should periodically check your serum electrolytes and creatinine. If you have peripheral vascular disease, this medication can aggravate symptoms of arterial insufficiency. For pheochromocytoma, your healthcare provider should first start therapy with an alpha blocker. Abrupt withdrawal during thyrotoxicosis could trigger a thyroid storm. You may not respond to the usual doses of epinephrine used for allergic reactions. Pregnancy & Lactation If you have untreated hypertension during pregnancy, it can lead to adverse outcomes for both you and your fetus. There are inconsistent reports of intrauterine growth restriction, preterm birth, and perinatal mortality associated with maternal use of beta blockers, including metoprolol, during pregnancy. Rare cases of jaundice, thrombocytopenia, and electrolyte imbalances have been reported in infants exposed to thiazide medications during pregnancy. Neonates born to mothers taking metoprolol during pregnancy may be at risk for hypotension, hypoglycemia, bradycardia, and respiratory depression. You should monitor your breastfed infant for signs of drowsiness or poor feeding. Doses of hydrochlorothiazide that lead to clinically significant diuresis may impair milk production. Side Effects Stopping suddenly may worsen your myocardial ischemia. This medication may make your congestive heart failure worse. If you have bronchospasm, it's best to avoid beta-blockers. You may experience bradycardia. If you have diabetes, this medication may mask symptoms of hypoglycemia and change your glucose levels, so be sure to monitor them. If you have peripheral vascular disease, this medication can aggravate symptoms of arterial insufficiency. Abruptly stopping this medication during thyrotoxicosis could trigger a thyroid storm. You may not respond to the usual doses of epinephrine used to treat allergic reactions. Warnings abrupt cessation may exacerbate myocardial ischemia may worsen congestive heart failure bronchospasm: avoid beta-blockers bradycardia avoid discontinuing therapy prior to major surgery diabetes: may mask symptoms of hypoglycemia and alter glucose levels; monitor monitor serum electrolytes and creatinine periodically peripheral vascular disease: can aggravate symptoms of arterial insufficiency pheochromocytoma: first initiate therapy with an alpha blocker abrupt withdrawal in thyrotoxicosis might precipitate a thyroid storm patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction Pregnancy & Lactation untreated hypertension during pregnancy can lead to adverse outcomes for the mother and the fetus there are inconsistent reports of intrauterine growth restriction, preterm birth, and perinatal mortality with maternal use of beta blockers, including metoprolol, during pregnancy there have been rare reports of jaundice, thrombocytopenia, and electrolyte imbalances in infants exposed to thiazide medications during pregnancy neonates born to mothers who are receiving metoprolol during pregnancy may be at risk for hypotension, hypoglycemia, bradycardia, and respiratory depression monitor the breastfed infant for drowsiness or poor feeding doses of hydrochlorothiazide associated with clinically significant diuresis have been associated with impaired milk production Side Effects abrupt cessation may exacerbate myocardial ischemia may worsen congestive heart failure bronchospasm: avoid beta-blockers bradycardia diabetes: may mask symptoms of hypoglycemia and alter glucose levels; monitor peripheral vascular disease: can aggravate symptoms of arterial insufficiency abrupt withdrawal in thyrotoxicosis might precipitate a thyroid storm patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction
Metoprolol Tartrate and Hydrochlorothiazide Rx tablet Sun Pharmaceutical Industries, Inc.	Popularity – score 0 out of 100 (least-viewed drug)	11 warnings	6 pregnancy and lactation warnings	8 side effects	Trend: was flat over 11 months; peaks in May, Jul.
Metoprolol Tartrate and Hydrochlorothiazide® · First marketed 2022 · Label last revised January 2, 2024View full label details → Warnings Stopping suddenly may worsen your myocardial ischemia. This medication may make your congestive heart failure worse. It's best to avoid beta-blockers. Be aware of bradycardia. Do not stop your therapy before major surgery. This medication may hide symptoms of hypoglycemia and change your glucose levels, so be sure to monitor them. Your healthcare provider should check your serum electrolytes and creatinine levels periodically. This medication can worsen symptoms of arterial insufficiency. Start your therapy with an alpha blocker first. Abruptly stopping in cases of thyrotoxicosis could trigger a thyroid storm. You may not respond to the usual doses of epinephrine for treating allergic reactions. Pregnancy & Lactation If you have untreated hypertension during pregnancy, it can lead to adverse outcomes for both you and your fetus. There are inconsistent reports of intrauterine growth restriction, preterm birth, and perinatal mortality associated with the use of beta blockers, including metoprolol, during pregnancy. Rare cases of jaundice, thrombocytopenia, and electrolyte imbalances have been reported in infants exposed to thiazide medications during pregnancy. Metoprolol can cross the placenta. If you are receiving metoprolol during pregnancy, your neonate may be at risk for hypotension, hypoglycemia, bradycardia, and respiratory depression. Your healthcare provider should observe neonates for symptoms of hypotension, bradycardia, hypoglycemia, and respiratory depression and manage them accordingly. Side Effects Stopping suddenly may worsen your myocardial ischemia. This medication may make your congestive heart failure worse. If you have bronchospasm, it's best to avoid beta-blockers. You may experience bradycardia. If you have diabetes, this medication may mask symptoms of hypoglycemia and change your glucose levels, so be sure to monitor them. If you have peripheral vascular disease, this medication can aggravate symptoms of arterial insufficiency. Abruptly stopping this medication during thyrotoxicosis could trigger a thyroid storm. You may not respond to the usual doses of epinephrine used for treating allergic reactions. Warnings abrupt cessation may exacerbate myocardial ischemia may worsen congestive heart failure avoid beta-blockers bradycardia avoid discontinuing therapy prior to major surgery may mask symptoms of hypoglycemia and alter glucose levels; monitor monitor serum electrolytes and creatinine periodically can aggravate symptoms of arterial insufficiency first initiate therapy with an alpha blocker abrupt withdrawal in thyrotoxicosis might precipitate a thyroid storm patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction Pregnancy & Lactation untreated hypertension during pregnancy can lead to adverse outcomes for the mother and the fetus there are inconsistent reports of intrauterine growth restriction, preterm birth, and perinatal mortality with maternal use of beta blockers, including metoprolol, during pregnancy there have been rare reports of jaundice, thrombocytopenia, and electrolyte imbalances in infants exposed to thiazide medications during pregnancy metoprolol crosses the placenta neonates born to mothers who are receiving metoprolol during pregnancy may be at risk for hypotension, hypoglycemia, bradycardia, and respiratory depression observe neonates for symptoms of hypotension, bradycardia, hypoglycemia and respiratory depression and manage accordingly Side Effects abrupt cessation may exacerbate myocardial ischemia may worsen congestive heart failure bronchospasm: avoid beta-blockers bradycardia diabetes: may mask symptoms of hypoglycemia and alter glucose levels; monitor peripheral vascular disease: can aggravate symptoms of arterial insufficiency abrupt withdrawal in thyrotoxicosis might precipitate a thyroid storm patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction
Micardis Hct (telmisartan and hydrochlorothiazide) Rx tablet Boehringer Ingelheim Pharmaceuticals, Inc.	Popularity – score 0 out of 100 (least-viewed drug)	9 warnings	9 pregnancy and lactation warnings	9 side effects	Trend: was flat over the year; peaks in Mar, Aug; lows in Jul, Nov.
Micardis Hct® · First marketed 2000 · Label last revised December 31, 2024View full label details → Warnings If you find out you are pregnant, please stop taking MICARDIS HCT as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. It's important to avoid exposing the fetus or newborn to this medication. Make sure to correct any volume or salt depletion before starting therapy. Be aware of signs and symptoms of low blood pressure. Your healthcare provider should monitor your renal function and potassium levels if you are at risk. Keep an eye out for any clinical signs of fluid or electrolyte imbalance. Watch for any signs of a hypersensitivity reaction. Be aware that acute myopia and secondary angle-closure glaucoma can occur. Pregnancy & Lactation MICARDIS HCT can harm your fetus if you take it while pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce your baby's kidney function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please stop taking MICARDIS HCT as soon as possible. Taking medications that act on the RAS in the second and third trimesters of pregnancy may lead to low amniotic fluid, decreased kidney function in your baby, which can cause kidney failure, underdeveloped lungs, skeletal deformities including skull issues, low blood pressure, and even death. If you are taking MICARDIS HCT during pregnancy, your healthcare provider should perform regular ultrasound examinations to check the environment around your baby. If low amniotic fluid is detected, your healthcare provider may recommend stopping MICARDIS HCT, unless it is essential for your health. Infants who were exposed to MICARDIS HCT in the womb should be closely monitored for low blood pressure, reduced urine output, and high potassium levels. Thiazides can cross the placenta, and using thiazides during pregnancy may increase the risk of jaundice, low platelet counts, and other adverse reactions that can also occur in adults. It's best to avoid using hydrochlorothiazide for other conditions (like heart disease) during pregnancy. Side Effects You may experience an upper respiratory tract infection. Dizziness can occur. Sinusitis is another possible side effect. You might have diarrhea. Fatigue may affect you. Some people report influenza-like symptoms. Nausea is also a possibility. Be aware of a hypersensitivity reaction. Your healthcare provider should monitor for acute myopia and secondary angle-closure glaucoma. Warnings when pregnancy is detected, discontinue MICARDIS HCT as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus avoid fetal or neonatal exposure correct volume or salt depletion before initiating therapy observe for signs and symptoms of hypotension monitor renal function and potassium in susceptible patients observe for clinical signs of fluid or electrolyte imbalance hypersensitivity reaction acute myopia and secondary angle-closure glaucoma Pregnancy & Lactation MICARDIS HCT can cause fetal harm when administered to a pregnant woman Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death When pregnancy is detected, discontinue MICARDIS HCT as soon as possible Use of drugs that act on the RAS in the second and third trimesters of pregnancy can result in oligohydramnios, reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death In patients taking MICARDIS HCT during pregnancy, perform serial ultrasound examinations to assess the intra-amniotic environment If oligohydramnios is observed, discontinue MICARDIS HCT, unless it is considered lifesaving for the mother Closely observe infants with histories of in utero exposure to MICARDIS HCT for hypotension, oliguria, and hyperkalemia Thiazides cross the placenta, and use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice, thrombocytopenia, and possible other adverse reactions that have occurred in adults The use of hydrochlorothiazide for other indications (e.g., heart disease) in pregnancy should be avoided Side Effects upper respiratory tract infection dizziness sinusitis diarrhea fatigue influenza-like symptoms nausea hypersensitivity Reaction Acute Myopia and Secondary Angle-Closure Glaucoma
Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide Rx tablet, film coated Endo USA, Inc.	Popularity – score 0 out of 100 (least-viewed drug)	9 warnings	12 pregnancy and lactation warnings	17 side effects	Trend: was flat over 11 months.
Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide® · First marketed 2016 · Label last revised August 30, 2024View full label details → Warnings If you find out you are pregnant, please stop taking olmesartan medoxomil, amlodipine, and hydrochlorothiazide tablets as soon as possible. Be aware that medications affecting the renin-angiotensin system can harm the developing fetus and may lead to serious complications. Make sure to correct any volume or salt depletion before starting treatment. Your healthcare provider should monitor your renal function and potassium levels if you are at risk. You may experience increased angina or myocardial infarction when starting or increasing the dosage of calcium channel blockers. Keep an eye out for any signs of fluid or electrolyte imbalance. There is a possibility of exacerbation or activation of systemic lupus erythematosus. Be cautious of acute angle-closure glaucoma. Sprue-like enteropathy has been reported. If no other cause is identified, consider discussing the discontinuation of olmesartan medoxomil, amlodipine, and hydrochlorothiazide tablets with your healthcare provider. Pregnancy & Lactation If you are pregnant, be aware that Olmesartan medoxomil, amlodipine, and hydrochlorothiazide tablets can cause harm to the fetus. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase the risk of complications for both you and your baby. As soon as you find out you are pregnant, please discontinue Olmesartan medoxomil, amlodipine, and hydrochlorothiazide tablets. You may want to consider alternative treatments for high blood pressure during your pregnancy. Having high blood pressure while pregnant can increase your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for your baby, including issues like intrauterine growth restriction and intrauterine death. If you are pregnant and using medications that affect the renin-angiotensin system during the second and third trimesters, be aware that this can lead to reduced kidney function in your baby, potentially resulting in serious conditions such as anuria, renal failure, lung development issues, skeletal deformities, low blood pressure, and even death. Thiazides can cross the placenta, and the levels in the umbilical vein can be similar to those in your bloodstream. Using thiazides during pregnancy may carry a risk of jaundice or low platelet counts in your baby. Since these medications do not prevent or change the course of preeclampsia, they should not be used to treat high blood pressure in pregnant women. It's best to avoid using HCTZ for other conditions during pregnancy. If you are nursing, please be advised that breastfeeding is not recommended while you are being treated with Olmesartan medoxomil, amlodipine, and hydrochlorothiazide tablets. Side Effects You may experience dizziness. You might notice peripheral edema. Headaches can occur. Fatigue is another possible side effect. You could develop nasopharyngitis. Muscle spasms may happen. Nausea is a potential effect. An upper respiratory tract infection could occur. Diarrhea may be experienced. You might have a urinary tract infection. Joint swelling can occur. Hypotension is a possible side effect. If you are taking calcium channel blockers, increased angina or myocardial infarction may occur when starting or increasing the dosage. Be aware of potential fluid or electrolyte imbalances. There may be an exacerbation or activation of systemic lupus erythematosus. Acute angle-closure glaucoma is a possible risk. Sprue-like enteropathy has been reported. Warnings when pregnancy is detected, discontinue olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume or salt depletion prior to administration monitor renal function and potassium in susceptible patients increased angina or myocardial infarction with calcium channel blockers may occur upon dosage initiation or increase observe for signs of fluid or electrolyte imbalance exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma sprue-like enteropathy has been reported. consider discontinuation of olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets in cases where no other etiology is found Pregnancy & Lactation Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets can cause fetal harm when administered to a pregnant woman Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death When pregnancy is detected, discontinue Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets as soon as possible Consider alternative antihypertensive therapy during pregnancy Hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications Hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death Oligohydramnios in pregnant women who use drugs affecting the renin-angiotensin system in the second and third trimesters of pregnancy can result in reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death Thiazides can cross the placenta, and concentrations reached in the umbilical vein approach those in the maternal plasma Use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia Since they do not prevent or alter the course of preeclampsia, these drugs should not be used to treat hypertension in pregnant women The use of HCTZ for other indications in pregnancy should be avoided Advise a nursing woman that breastfeeding is not recommended during treatment with Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets Side Effects dizziness peripheral edema headache fatigue nasopharyngitis muscle spasms nausea upper respiratory tract infection diarrhea urinary tract infection joint swelling hypotension increased angina or myocardial infarction with calcium channel blockers may occur upon dosage initiation or increase fluid or electrolyte imbalance exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma sprue-like enteropathy has been reported
Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide Rx tablet, film coated REMEDYREPACK INC.	Popularity – score 0 out of 100 (least-viewed drug)	9 warnings	10 pregnancy and lactation warnings	17 side effects	Trend: was flat over 11 months.
Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide® · First marketed 2024 · Label last revised January 7, 2026View full label details → Warnings If you find out you are pregnant, please stop taking olmesartan medoxomil, amlodipine, and hydrochlorothiazide tablets as soon as possible. Be aware that medications affecting the renin-angiotensin system can harm the developing fetus and may lead to serious complications. Make sure to correct any volume or salt depletion before starting treatment. Your healthcare provider should monitor your renal function and potassium levels if you are at risk. You may experience increased angina or myocardial infarction when starting or increasing the dosage of calcium channel blockers. Keep an eye out for any signs of fluid or electrolyte imbalance. There is a possibility of exacerbation or activation of systemic lupus erythematosus. Be cautious of acute angle-closure glaucoma. Sprue-like enteropathy has been reported. If no other cause is identified, consider discussing the discontinuation of olmesartan medoxomil, amlodipine, and hydrochlorothiazide tablets with your healthcare provider. Pregnancy & Lactation Olmesartan medoxomil, amlodipine, and hydrochlorothiazide tablets can cause harm to your fetus if you are pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce your fetus's renal function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please stop taking Olmesartan medoxomil, amlodipine, and hydrochlorothiazide tablets as soon as possible. You should consider alternative treatments for high blood pressure during your pregnancy. Having high blood pressure while pregnant increases your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for your fetus, including intrauterine growth restriction and intrauterine death. If you are pregnant and using medications that affect the renin-angiotensin system during the second and third trimesters, it can lead to oligohydramnios, which may result in reduced renal function for your fetus, potentially causing anuria, renal failure, lung development issues, skeletal deformations, low blood pressure, and even death. Thiazides can cross the placenta, and the levels in the umbilical vein can be similar to those in your plasma. Using thiazides during pregnancy may increase the risk of jaundice or low platelet counts in your baby. These medications should not be used to manage high blood pressure in pregnant women. Side Effects You may experience dizziness. You might notice peripheral edema. Headaches can occur. Fatigue is a possible side effect. You could develop nasopharyngitis. Muscle spasms may happen. Nausea is something to watch for. An upper respiratory tract infection could arise. Diarrhea may occur. You might experience a urinary tract infection. Joint swelling is a potential side effect. Hypotension can happen. If you are taking calcium channel blockers, be aware that increased angina or myocardial infarction may occur upon dosage initiation or increase. You should be mindful of fluid or electrolyte imbalances. There is a possibility of exacerbation or activation of systemic lupus erythematosus. Acute angle-closure glaucoma is a serious condition to be aware of. Sprue-like enteropathy may develop. Warnings when pregnancy is detected, discontinue olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume or salt depletion prior to administration monitor renal function and potassium in susceptible patients increased angina or myocardial infarction with calcium channel blockers may occur upon dosage initiation or increase observe for signs of fluid or electrolyte imbalance exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma sprue-like enteropathy has been reported. consider discontinuation of olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets in cases where no other etiology is found Pregnancy & Lactation Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets can cause fetal harm when administered to a pregnant woman Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death When pregnancy is detected, discontinue Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets as soon as possible Consider alternative antihypertensive therapy during pregnancy Hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications Hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death Oligohydramnios in pregnant women who use drugs affecting the renin-angiotensin system in the second and third trimesters of pregnancy can result in reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death Thiazides can cross the placenta, and concentrations reached in the umbilical vein approach those in the maternal plasma Use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia These drugs should not be used to treat hypertension in pregnant women Side Effects dizziness peripheral edema headache fatigue nasopharyngitis muscle spasms nausea upper respiratory tract infection diarrhea urinary tract infection joint swelling hypotension increased angina or myocardial infarction with calcium channel blockers upon dosage initiation or increase fluid or electrolyte imbalance exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma sprue-like enteropathy
Olmesartan Medoxomil Amlodipine and Hydrochlorothiazide Rx tablet, film coated Macleods Pharmaceuticals Limited	Popularity – score 0 out of 100 (least-viewed drug)	9 warnings	10 pregnancy and lactation warnings	17 side effects	Trend: rose 29% over the year; lows in Mar, May, Sep; bumpy overall.
Olmesartan Medoxomil Amlodipine and Hydrochlorothiazide® · First marketed 2025 · Label last revised August 4, 2025View full label details → Warnings If you find out you are pregnant, please stop taking olmesartan medoxomil, amlodipine, and hydrochlorothiazide tablets as soon as possible. Be aware that medications affecting the renin-angiotensin system can harm the developing fetus and may lead to serious complications. Make sure to correct any volume or salt depletion before starting treatment. Your healthcare provider should monitor your renal function and potassium levels if you are at risk. You may experience increased angina or myocardial infarction when starting or increasing the dosage of calcium channel blockers. Keep an eye out for any signs of fluid or electrolyte imbalance. There is a possibility of exacerbation or activation of systemic lupus erythematosus. Be cautious of acute angle-closure glaucoma. Sprue-like enteropathy has been reported. If no other cause is identified, consider discussing the discontinuation of olmesartan medoxomil, amlodipine, and hydrochlorothiazide tablets with your healthcare provider. Pregnancy & Lactation Olmesartan medoxomil, amlodipine, and hydrochlorothiazide tablets can cause harm to your fetus if you are pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of your pregnancy may reduce your fetus's kidney function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please stop taking olmesartan medoxomil, amlodipine, and hydrochlorothiazide tablets as soon as possible. You should consider alternative antihypertensive treatments during your pregnancy. Having high blood pressure during pregnancy raises your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for your fetus, including intrauterine growth restriction and intrauterine death. If you are pregnant and use medications that affect the renin-angiotensin system during the second and third trimesters, oligohydramnios may occur, which can lead to reduced kidney function in your fetus, resulting in anuria, renal failure, underdeveloped lungs, skeletal deformities (including skull hypoplasia), low blood pressure, and even death. Thiazides can cross the placenta, and the levels in the umbilical vein can be similar to those in your bloodstream. Using thiazides during pregnancy may increase the risk of jaundice or low platelet counts in your fetus or newborn. It is not recommended to breastfeed while you are being treated with olmesartan medoxomil, amlodipine, and hydrochlorothiazide tablets. Side Effects You may experience dizziness. You might notice peripheral edema. Headaches can occur. Fatigue is a possible side effect. You could develop nasopharyngitis. Muscle spasms may happen. Nausea is something to watch for. An upper respiratory tract infection could occur. Diarrhea may be a side effect. You might experience a urinary tract infection. Joint swelling can happen. Hypotension is a potential concern. If you are taking calcium channel blockers, be aware of increased angina or myocardial infarction when starting or increasing the dosage. Fluid or electrolyte imbalance may occur. There is a risk of exacerbation or activation of systemic lupus erythematosus. Acute angle-closure glaucoma is a serious condition to be aware of. Sprue-like enteropathy may develop. Warnings when pregnancy is detected, discontinue olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume or salt depletion prior to administration monitor renal function and potassium in susceptible patients increased angina or myocardial infarction with calcium channel blockers may occur upon dosage initiation or increase observe for signs of fluid or electrolyte imbalance exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma sprue-like enteropathy has been reported. consider discontinuation of olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets in cases where no other etiology is found Pregnancy & Lactation olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets as soon as possible consider alternative antihypertensive therapy during pregnancy hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death oligohydramnios in pregnant women who use drugs affecting the renin-angiotensin system in the second and third trimesters of pregnancy can result in reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death thiazides can cross the placenta, and concentrations reached in the umbilical vein approach those in the maternal plasma use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia breastfeeding is not recommended during treatment with olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets Side Effects dizziness peripheral edema headache fatigue nasopharyngitis muscle spasms nausea upper respiratory tract infection diarrhea urinary tract infection joint swelling hypotension increased angina or myocardial infarction with calcium channel blockers upon dosage initiation or increase fluid or electrolyte imbalance exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma sprue-like enteropathy
Olmesartan Medoxomil and Amlodipine Besylate and Hydrochlorothiazide Rx tablet, film coated Slate Run Pharmaceuticals, LLC	Popularity – score 0 out of 100 (least-viewed drug)	9 warnings	11 pregnancy and lactation warnings	16 side effects	Trend: was flat over 11 months.
Olmesartan Medoxomil and Amlodipine Besylate and Hydrochlorothiazide® · First marketed 2025 · Label last revised June 30, 2025View full label details → Warnings If you find out you are pregnant, please stop taking olmesartan medoxomil, amlodipine, and hydrochlorothiazide tablets as soon as possible. Be aware that medications affecting the renin-angiotensin system can harm the developing fetus and may lead to serious complications. Make sure to correct any volume or salt depletion before starting treatment. Your healthcare provider should monitor your renal function and potassium levels if you are at risk. You may experience increased angina or myocardial infarction when starting or increasing the dosage of calcium channel blockers. Keep an eye out for any signs of fluid or electrolyte imbalance. There is a possibility of exacerbation or activation of systemic lupus erythematosus. Be cautious of acute angle-closure glaucoma. Sprue-like enteropathy has been reported. If no other cause is identified, consider discussing the discontinuation of olmesartan medoxomil, amlodipine, and hydrochlorothiazide tablets with your healthcare provider. Pregnancy & Lactation Olmesartan medoxomil, amlodipine, and hydrochlorothiazide tablets can cause harm to your fetus if you are pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of your pregnancy may reduce your fetus's renal function and increase the risk of morbidity and mortality for both you and your baby. If you find out you are pregnant, please discontinue olmesartan medoxomil, amlodipine, and hydrochlorothiazide tablets as soon as possible. You should consider alternative antihypertensive therapy during your pregnancy. Hypertension during pregnancy raises your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can increase the risk for your fetus of intrauterine growth restriction and intrauterine death. Oligohydramnios in pregnant women using medications that affect the renin-angiotensin system during the second and third trimesters can lead to reduced fetal renal function, resulting in anuria, renal failure, fetal lung hypoplasia, skeletal deformations (including skull hypoplasia), hypotension, and even death. Thiazides can cross the placenta, and the concentrations in the umbilical vein can be similar to those in your plasma. Using thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia. You should avoid using HCTZ for other indications during your pregnancy. Your healthcare provider should closely observe infants with a history of in utero exposure to olmesartan for signs of hypotension, oliguria, and hyperkalemia. Side Effects You may experience dizziness. You might notice peripheral edema. Headaches can occur. Fatigue is a possible side effect. You could develop nasopharyngitis. Muscle spasms may happen. Nausea is something to watch for. An upper respiratory tract infection could occur. Diarrhea may be a side effect. You might experience a urinary tract infection. Joint swelling can happen. Hypotension is a potential side effect. If you are taking calcium channel blockers, increased angina or myocardial infarction may occur when starting or increasing the dosage. There may be an exacerbation or activation of systemic lupus erythematosus. Acute angle-closure glaucoma is a risk. Sprue-like enteropathy has been reported. Warnings when pregnancy is detected, discontinue olmesartan medoxomil, amlodipine, and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume or salt depletion prior to administration monitor renal function and potassium in susceptible patients increased angina or myocardial infarction with calcium channel blockers may occur upon dosage initiation or increase observe for signs of fluid or electrolyte imbalance exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma sprue-like enteropathy has been reported. consider discontinuation of olmesartan medoxomil, amlodipine, and hydrochlorothiazide tablets in cases where no other etiology is found Pregnancy & Lactation olmesartan medoxomil, amlodipine, and hydrochlorothiazide tablets can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue olmesartan medoxomil, amlodipine, and hydrochlorothiazide tablets as soon as possible consider alternative antihypertensive therapy during pregnancy hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death oligohydramnios in pregnant women who use drugs affecting the renin-angiotensin system in the second and third trimesters of pregnancy can result in reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death thiazides can cross the placenta, and concentrations reached in the umbilical vein approach those in the maternal plasma use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia the use of HCTZ for other indications in pregnancy should be avoided closely observe infants with histories of in utero exposure to olmesartan for hypotension, oliguria, and hyperkalemia Side Effects dizziness peripheral edema headache fatigue nasopharyngitis muscle spasms nausea upper respiratory tract infection diarrhea urinary tract infection joint swelling hypotension increased angina or myocardial infarction with calcium channel blockers may occur upon dosage initiation or increase exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma sprue-like enteropathy has been reported
Olmesartan Medoxomil and Hydrochlorothiazide Rx tablet, film coated Macleods Pharmaceuticals Limited	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	10 pregnancy and lactation warnings	7 side effects	Trend: was flat over 11 months; peaks in Jun, Aug, Sep, Oct, Nov, Dec.
Olmesartan Medoxomil and Hydrochlorothiazide® · First marketed 2023 · Label last revised May 22, 2025View full label details → Warnings Please stop taking olmesartan medoxomil and hydrochlorothiazide tablets as soon as you find out you are pregnant. Medications that directly affect the renin-angiotensin system can harm your developing fetus, potentially leading to serious injury or death. Make sure to correct any volume depletion before starting this medication. Your healthcare provider should regularly check your renal function and potassium levels if you are at risk. Be aware of any signs of fluid or electrolyte imbalance. This medication may lead to acute angle-closure glaucoma. If no other cause is identified, you may want to discuss with your healthcare provider the possibility of stopping olmesartan medoxomil and hydrochlorothiazide tablets. Pregnancy & Lactation Olmesartan medoxomil and hydrochlorothiazide tablets can cause harm to your fetus if you are pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce your baby's kidney function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please stop taking olmesartan medoxomil and hydrochlorothiazide tablets as soon as possible. Consider alternative antihypertensive treatments during your pregnancy. Having high blood pressure during pregnancy raises your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for your baby of intrauterine growth restriction and intrauterine death. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can lead to oligohydramnios, which may result in reduced kidney function for your baby, potentially causing anuria, renal failure, underdeveloped lungs, skeletal deformities, including skull hypoplasia, low blood pressure, and even death. Thiazides can cross the placenta, and the levels in the umbilical vein can be similar to those in your bloodstream. Taking thiazides during pregnancy may increase the risk of jaundice or low platelet counts in your baby. It is not recommended to breastfeed while you are being treated with olmesartan medoxomil and hydrochlorothiazide tablets. Side Effects You may experience nausea. You might have hyperuricemia. Dizziness can occur. An upper respiratory infection may develop. You could experience hypotension. There is a risk of acute angle-closure glaucoma. Sprue-like enteropathy is a possible side effect. Warnings discontinue olmesartan medoxomil and hydrochlorothiazide tablets as soon as possible when pregnancy is detected drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume-depletion prior to administration monitor renal function and potassium in susceptible patients observe for signs of fluid or electrolyte imbalance acute angle-closure glaucoma consider discontinuation of olmesartan medoxomil and hydrochlorothiazide tablets in cases where no other etiology is found Pregnancy & Lactation olmesartan medoxomil and hydrochlorothiazide tablets can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity, and death when pregnancy is detected, discontinue olmesartan medoxomil and hydrochlorothiazide tablets as soon as possible use alternative antihypertensive therapy during pregnancy hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death oligohydramnios in pregnant women who use drugs affecting the renin-angiotensin system in the second and third trimesters of pregnancy can result in reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death thiazides can cross the placenta, and concentrations reached in the umbilical vein approach those in the maternal plasma use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia breastfeeding is not recommended during treatment with olmesartan medoxomil and hydrochlorothiazide tablets Side Effects nausea hyperuricemia dizziness upper respiratory infection hypotension acute angle-closure glaucoma sprue-like enteropathy
Olmesartan Medoxomil and Hydrochlorothiazide Rx tablet, film coated REMEDYREPACK INC.	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	11 pregnancy and lactation warnings	7 side effects	Trend: rose 22% over the year.
Olmesartan Medoxomil and Hydrochlorothiazide® · First marketed 2025 · Label last revised November 10, 2025View full label details → Warnings Please stop taking olmesartan medoxomil and hydrochlorothiazide tablets as soon as you find out you are pregnant. Medications that directly affect the renin-angiotensin system can harm your developing fetus. Make sure to correct any volume depletion before starting treatment. Your healthcare provider should regularly check your renal function and potassium levels if you are at risk. Be alert for any signs of fluid or electrolyte imbalance. Watch for symptoms of acute angle-closure glaucoma. If no other cause is identified, you may want to discuss stopping olmesartan medoxomil and hydrochlorothiazide tablets with your healthcare provider. Pregnancy & Lactation Olmesartan medoxomil and hydrochlorothiazide tablets can cause harm to your fetus if you are pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce your baby's kidney function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please stop taking olmesartan medoxomil and hydrochlorothiazide tablets as soon as possible. Consider alternative antihypertensive treatments during your pregnancy. Having high blood pressure during pregnancy raises your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for your baby of intrauterine growth restriction and intrauterine death. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can lead to oligohydramnios, which may result in reduced kidney function for your baby, potentially causing anuria, renal failure, underdeveloped lungs, skeletal deformities, including skull hypoplasia, low blood pressure, and even death. Thiazides can cross the placenta, and the levels in the umbilical vein can be similar to those in your bloodstream. Using thiazides during pregnancy may increase the risk of jaundice or low platelet counts in your baby. It is best to avoid using HCTZ for other conditions during your pregnancy. Breastfeeding is not recommended while you are being treated with olmesartan medoxomil and hydrochlorothiazide tablets. Side Effects You may experience nausea. You might have hyperuricemia. Dizziness can occur. An upper respiratory infection may develop. You could experience hypotension. Your healthcare provider should monitor you for acute angle-closure glaucoma. Sprue-like enteropathy is a possible side effect. Warnings discontinue olmesartan medoxomil and hydrochlorothiazide tablets as soon as possible when pregnancy is detected drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume-depletion prior to administration monitor renal function and potassium in susceptible patients observe for signs of fluid or electrolyte imbalance acute angle-closure glaucoma consider discontinuation of olmesartan medoxomil and hydrochlorothiazide tablets in cases where no other etiology is found Pregnancy & Lactation olmesartan medoxomil and hydrochlorothiazide tablets can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity, and death when pregnancy is detected, discontinue olmesartan medoxomil and hydrochlorothiazide tablets as soon as possible use alternative antihypertensive therapy during pregnancy hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death oligohydramnios in pregnant women who use drugs affecting the renin-angiotensin system in the second and third trimesters of pregnancy can result in reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death thiazides can cross the placenta, and concentrations reached in the umbilical vein approach those in the maternal plasma use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia the use of HCTZ for other indications in pregnancy should be avoided breastfeeding is not recommended during treatment with olmesartan medoxomil and hydrochlorothiazide tablets Side Effects nausea hyperuricemia dizziness upper respiratory infection hypotension acute angle-closure glaucoma sprue-like enteropathy
Olmesartan Medoxomil and Hydrochlorothiazide Rx tablet, film coated NorthStar RxLLC	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	6 pregnancy and lactation warnings	7 side effects	Trend: was flat over 11 months; peaks in Jun, Aug, Sep, Oct, Nov, Dec.
Olmesartan Medoxomil and Hydrochlorothiazide® · First marketed 2024 · Label last revised April 10, 2025View full label details → Warnings Please stop taking olmesartan medoxomil and hydrochlorothiazide tablets as soon as you find out you are pregnant. Medications that directly affect the renin-angiotensin system can harm your developing fetus, potentially leading to serious injury or death. Make sure to correct any volume depletion before starting this medication. Your healthcare provider should regularly check your renal function and potassium levels if you are at risk. Be aware of any signs of fluid or electrolyte imbalance. This medication may lead to acute angle-closure glaucoma. If no other cause is identified, you may want to discuss with your healthcare provider the possibility of stopping olmesartan medoxomil and hydrochlorothiazide tablets. Pregnancy & Lactation Using drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal renal function and increase the risk of morbidity and death for both the fetus and neonate. As soon as you confirm your pregnancy, please discontinue olmesartan medoxomil and hydrochlorothiazide tablets. If there is no suitable alternative to therapy with drugs affecting the renin-angiotensin system for your specific situation, it's important to discuss the potential risks to your fetus with your healthcare provider. If oligohydramnios is detected, you should stop taking olmesartan medoxomil and hydrochlorothiazide tablets, unless your healthcare provider determines that it is lifesaving for you. Your healthcare provider should closely monitor infants who were exposed to olmesartan medoxomil and hydrochlorothiazide tablets in utero for signs of hypotension, oliguria, and hyperkalemia. You and your healthcare provider should decide whether to continue nursing or to stop taking olmesartan medoxomil and hydrochlorothiazide tablets, considering how important the medication is for your health. Side Effects You may experience nausea. You might have hyperuricemia. Dizziness can occur. An upper respiratory infection may develop. You could experience hypotension. Your healthcare provider should monitor you for acute angle-closure glaucoma. Sprue-like enteropathy is a possible side effect. Warnings discontinue olmesartan medoxomil and hydrochlorothiazide tablets as soon as possible when pregnancy is detected drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume-depletion prior to administration monitor renal function and potassium in susceptible patients observe for signs of fluid or electrolyte imbalance acute angle-closure glaucoma consider discontinuation of olmesartan medoxomil and hydrochlorothiazide tablets in cases where no other etiology is found Pregnancy & Lactation use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity, and death when pregnancy is detected, discontinue olmesartan medoxomil and hydrochlorothiazide tablets as soon as possible in the unusual case that there is no appropriate alternative to therapy with drugs affecting the renin-angiotensin system for a particular patient, apprise the mother of the potential risk to the fetus if oligohydramnios is observed, discontinue olmesartan medoxomil and hydrochlorothiazide tablets, unless it is considered lifesaving for the mother closely observe infants with histories of in utero exposure to olmesartan medoxomil and hydrochlorothiazide tablets for hypotension, oliguria, and hyperkalemia a decision should be made whether to discontinue nursing or discontinue olmesartan medoxomil and hydrochlorothiazide tablets, taking into account the importance of the drug to the mother Side Effects nausea hyperuricemia dizziness upper respiratory infection hypotension acute angle-closure glaucoma sprue-like enteropathy
Olmesartan Medoxomil and Hydrochlorothiazide Rx tablet, film coated Aurobindo Pharma Limited	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	10 pregnancy and lactation warnings	8 side effects	Trend: was flat over 11 months; peaks in Jun, Aug, Sep, Oct, Nov, Dec.
Olmesartan Medoxomil and Hydrochlorothiazide® · First marketed 2017 · Label last revised June 3, 2025View full label details → Warnings If you find out you are pregnant, please stop taking olmesartan medoxomil and hydrochlorothiazide as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. Make sure to correct any volume depletion before starting treatment. Your healthcare provider should regularly check your renal function and potassium levels if you are at risk. Be alert for any signs of fluid or electrolyte imbalance. Watch for symptoms of acute angle-closure glaucoma. Sprue-like enteropathy has been reported. If no other cause is identified, consider discussing the discontinuation of olmesartan medoxomil and hydrochlorothiazide with your healthcare provider. Pregnancy & Lactation Olmesartan medoxomil and hydrochlorothiazide can cause harm to your fetus if you are pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of your pregnancy can reduce your fetus's renal function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please discontinue olmesartan medoxomil and hydrochlorothiazide as soon as possible. Consider alternative antihypertensive therapies during your pregnancy. Having hypertension during pregnancy raises your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. Hypertension can also increase the risk for your fetus, including intrauterine growth restriction and intrauterine death. If you are pregnant and using medications that affect the renin-angiotensin system during the second and third trimesters, oligohydramnios may occur, which can lead to reduced fetal renal function, anuria, renal failure, fetal lung hypoplasia, skeletal deformations (including skull hypoplasia), hypotension, and even death. Thiazides can cross the placenta, and the concentrations in the umbilical vein can be similar to those in your plasma. Using thiazides during pregnancy may carry a risk of fetal or neonatal jaundice or thrombocytopenia. It is not recommended to breastfeed while being treated with olmesartan medoxomil and hydrochlorothiazide. Side Effects You may experience nausea. You might have hyperuricemia. Dizziness can occur. An upper respiratory infection may develop. You could experience hypotension. There may be a fluid or electrolyte imbalance. Your healthcare provider should monitor you for acute angle-closure glaucoma. Sprue-like enteropathy is a possible side effect. Warnings when pregnancy is detected, discontinue olmesartan medoxomil and hydrochlorothiazide as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume-depletion prior to administration monitor renal function and potassium in susceptible patients observe for signs of fluid or electrolyte imbalance acute angle-closure glaucoma sprue-like enteropathy has been reported. consider discontinuation of olmesartan medoxomil and hydrochlorothiazide in cases where no other etiology is found Pregnancy & Lactation olmesartan medoxomil and hydrochlorothiazide can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue olmesartan medoxomil and hydrochlorothiazide as soon as possible use alternative antihypertensive therapy during pregnancy hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death oligohydramnios in pregnant women who use drugs affecting the renin-angiotensin system in the second and third trimesters of pregnancy can result in reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death thiazides can cross the placenta, and concentrations reached in the umbilical vein approach those in the maternal plasma use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia breastfeeding is not recommended during treatment with olmesartan medoxomil and hydrochlorothiazide Side Effects nausea hyperuricemia dizziness upper respiratory infection hypotension fluid or electrolyte imbalance acute angle-closure glaucoma sprue-like enteropathy
Olmesartan Medoxomil and Hydrochlorothiazide Rx tablet, film coated Ascend Laboratories, LLC	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	6 pregnancy and lactation warnings	7 side effects	Trend: was flat over 11 months; peaks in Jun, Aug, Sep, Oct, Nov, Dec.
Olmesartan Medoxomil and Hydrochlorothiazide® · First marketed 2025 · Label last revised April 21, 2025View full label details → Warnings If you find out you are pregnant, please stop taking olmesartan medoxomil and hydrochlorothiazide tablets as soon as possible. Be aware that medications affecting the renin-angiotensin system can harm the developing fetus and may lead to serious complications. Make sure to correct any volume depletion before starting treatment. Your healthcare provider should regularly check your renal function and potassium levels if you are at risk. Keep an eye out for any signs of fluid or electrolyte imbalance. Be cautious of acute angle-closure glaucoma. There have been reports of sprue-like enteropathy. If no other cause is identified, consider discussing the discontinuation of olmesartan medoxomil and hydrochlorothiazide tablets with your healthcare provider. Pregnancy & Lactation Using drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal renal function and increase the risk of morbidity and death for both the fetus and neonate. Once you confirm your pregnancy, please discontinue olmesartan medoxomil and hydrochlorothiazide tablets as soon as possible. If there is no suitable alternative to therapy with drugs affecting the renin-angiotensin system for your specific situation, discuss the potential risks to your fetus with your healthcare provider. If oligohydramnios is observed, your healthcare provider may recommend discontinuing olmesartan medoxomil and hydrochlorothiazide tablets, unless it is deemed lifesaving for you. Your healthcare provider should closely monitor infants with a history of in utero exposure to olmesartan medoxomil and hydrochlorothiazide tablets for signs of hypotension, oliguria, and hyperkalemia. You and your healthcare provider should decide whether to continue nursing or to discontinue olmesartan medoxomil and hydrochlorothiazide tablets, considering the importance of the medication for you. Side Effects You may experience nausea. You might have hyperuricemia. Dizziness can occur. An upper respiratory infection may develop. You could experience hypotension. Your healthcare provider should monitor you for acute angle-closure glaucoma. Sprue-like enteropathy is a possible side effect. Warnings when pregnancy is detected, discontinue olmesartan medoxomil and hydrochlorothiazide tablet as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume-depletion prior to administration monitor renal function and potassium in susceptible patients observe for signs of fluid or electrolyte imbalance acute angle-closure glaucoma sprue-like enteropathy has been reported. consider discontinuation of olmesartan medoxomil and hydrochlorothiazide tablet in cases where no other etiology is found Pregnancy & Lactation use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity, and death when pregnancy is detected, discontinue olmesartan medoxomil and hydrochlorothiazide tablet as soon as possible in the unusual case that there is no appropriate alternative to therapy with drugs affecting the renin-angiotensin system for a particular patient, apprise the mother of the potential risk to the fetus if oligohydramnios is observed, discontinue olmesartan medoxomil and hydrochlorothiazide tablet, unless it is considered lifesaving for the mother closely observe infants with histories of in utero exposure to olmesartan medoxomil and hydrochlorothiazide tablet for hypotension, oliguria, and hyperkalemia a decision should be made whether to discontinue nursing or discontinue olmesartan medoxomil and hydrochlorothiazide tablet, taking into account the importance of the drug to the mother Side Effects nausea hyperuricemia dizziness upper respiratory infection hypotension acute angle-closure glaucoma sprue-like enteropathy
Olmesartan Medoxomil and Hydrochlorothiazide Rx tablet Alembic Pharmaceuticals Limited	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	6 pregnancy and lactation warnings	7 side effects	Trend: was flat over 11 months; peaks in Jun, Aug, Sep, Oct, Nov, Dec.
Olmesartan Medoxomil and Hydrochlorothiazide® · First marketed 2017 · Label last revised January 19, 2023View full label details → Warnings If you find out you are pregnant, please stop taking olmesartan medoxomil and hydrochlorothiazide as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. Make sure to correct any volume depletion before starting treatment. Your healthcare provider should monitor your renal function and potassium levels if you are at risk. Be alert for any signs of fluid or electrolyte imbalance. Watch for symptoms of acute angle-closure glaucoma. Sprue-like enteropathy has been reported. If no other cause is identified, consider discussing the discontinuation of olmesartan medoxomil and hydrochlorothiazide tablets with your healthcare provider. Pregnancy & Lactation Using drugs that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase the risk of complications for both the fetus and newborn. As soon as you confirm your pregnancy, please discontinue olmesartan medoxomil and hydrochlorothiazide tablets. If there is no suitable alternative to therapy with drugs affecting the renin-angiotensin system for your specific situation, make sure to discuss the potential risks to your fetus with your healthcare provider. If you notice oligohydramnios, please stop taking olmesartan medoxomil and hydrochlorothiazide tablets, unless your healthcare provider determines it is essential for your health. Your healthcare provider should closely monitor infants who were exposed to olmesartan medoxomil and hydrochlorothiazide tablets in utero for signs of low blood pressure, reduced urine output, and high potassium levels. You and your healthcare provider should decide whether to continue nursing or to stop taking olmesartan medoxomil and hydrochlorothiazide tablets, considering how important the medication is for your health. Side Effects You may experience nausea. You might have elevated uric acid levels (hyperuricemia). Dizziness can occur. An upper respiratory infection may develop. You could experience low blood pressure (hypotension). There is a risk of acute angle-closure glaucoma. You may experience symptoms similar to sprue-like enteropathy. Warnings when pregnancy is detected, discontinue olmesartan medoxomil and hydrochlorothiazide as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume-depletion prior to administration monitor renal function and potassium in susceptible patients observe for signs of fluid or electrolyte imbalance acute angle-closure glaucoma sprue-like enteropathy has been reported. consider discontinuation of olmesartan medoxomil and hydrochlorothiazide tablets in cases where no other etiology is found Pregnancy & Lactation use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity, and death when pregnancy is detected, discontinue olmesartan medoxomil and hydrochlorothiazide tablets as soon as possible in the unusual case that there is no appropriate alternative to therapy with drugs affecting the renin-angiotensin system for a particular patient, apprise the mother of the potential risk to the fetus if oligohydramnios is observed, discontinue olmesartan medoxomil and hydrochlorothiazide tablets, unless it is considered lifesaving for the mother closely observe infants with histories of in utero exposure to olmesartan medoxomil and hydrochlorothiazide tablets for hypotension, oliguria, and hyperkalemia a decision should be made whether to discontinue nursing or discontinue olmesartan medoxomil and hydrochlorothiazide tablets, taking into account the importance of the drug to the mother Side Effects nausea hyperuricemia dizziness upper respiratory infection hypotension acute angle-closure glaucoma sprue-like enteropathy
Olmesartan Medoxomil and Hydrochlorothiazide Rx tablet Lifestar Pharma LLC	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	12 pregnancy and lactation warnings	8 side effects	Trend: was flat over 11 months; peaks in Jun, Aug, Sep, Oct, Nov, Dec.
Olmesartan Medoxomil and Hydrochlorothiazide® · First marketed 2020 · Label last revised December 9, 2025View full label details → Warnings If you find out you are pregnant, please stop taking olmesartan medoxomil and hydrochlorothiazide tablets as soon as possible. Be aware that medications affecting the renin-angiotensin system can harm the developing fetus and may lead to serious complications. Make sure to correct any volume depletion before starting treatment. Your healthcare provider should regularly check your renal function and potassium levels if you are at risk. Keep an eye out for any signs of fluid or electrolyte imbalance. Be cautious of acute angle-closure glaucoma. There have been reports of sprue-like enteropathy. If no other cause is identified, consider discussing the discontinuation of olmesartan medoxomil and hydrochlorothiazide tablets with your healthcare provider. Pregnancy & Lactation Olmesartan medoxomil and hydrochlorothiazide tablets can cause harm to the fetus if you take them while pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please stop taking olmesartan medoxomil and hydrochlorothiazide tablets as soon as possible. Consider alternative antihypertensive treatments during your pregnancy. Having high blood pressure during pregnancy raises your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for your baby of intrauterine growth restriction and intrauterine death. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can lead to oligohydramnios, which may result in reduced kidney function in the fetus, potentially causing anuria, renal failure, underdeveloped lungs, skeletal deformities, including skull hypoplasia, low blood pressure, and even death. Thiazides can cross the placenta, and the levels in the umbilical vein can be similar to those in your bloodstream. Taking thiazides during pregnancy may increase the risk of jaundice or low platelet counts in your baby. Since these medications do not prevent or change the course of preeclampsia, they should not be used to manage high blood pressure in pregnant women. It's best to avoid using HCTZ for other conditions during pregnancy. Your healthcare provider should closely monitor infants who were exposed to olmesartan medoxomil and hydrochlorothiazide tablets in utero for signs of low blood pressure, reduced urine output, and high potassium levels. Side Effects You may experience nausea. You might have hyperuricemia. Dizziness can occur. An upper respiratory infection may develop. You could experience hypotension. There may be a fluid or electrolyte imbalance. Your healthcare provider should monitor you for acute angle-closure glaucoma. Sprue-like enteropathy is a possible side effect. Warnings when pregnancy is detected, discontinue olmesartan medoxomil and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume-depletion prior to administration monitor renal function and potassium in susceptible patients observe for signs of fluid or electrolyte imbalance acute angle-closure glaucoma sprue-like enteropathy has been reported. consider discontinuation of olmesartan medoxomil and hydrochlorothiazide tablets in cases where no other etiology is found Pregnancy & Lactation olmesartan medoxomil and hydrochlorothiazide tablets can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue olmesartan medoxomil and hydrochlorothiazide tablets as soon as possible use alternative antihypertensive therapy during pregnancy hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death oligohydramnios in pregnant women who use drugs affecting the renin-angiotensin system in the second and third trimesters of pregnancy can result in reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death thiazides can cross the placenta, and concentrations reached in the umbilical vein approach those in the maternal plasma use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia since they do not prevent or alter the course of preeclampsia, these drugs should not be used to treat hypertension in pregnant women the use of HCTZ for other indications in pregnancy should be avoided closely observe infants with histories of in utero exposure to olmesartan medoxomil and hydrochlorothiazide tablets for hypotension, oliguria, and hyperkalemia Side Effects nausea hyperuricemia dizziness upper respiratory infection hypotension fluid or electrolyte imbalance acute angle-closure glaucoma sprue-like enteropathy
Olmesartan Medoxomil and Hydrochlorothiazide Rx tablet Solco Healthcare US, LLC	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	0 pregnancy and lactation warnings	7 side effects	Trend: was flat over 11 months; peaks in Jun, Aug, Sep, Oct, Nov, Dec.
Olmesartan Medoxomil and Hydrochlorothiazide® · First marketed 2017 · Label last revised April 19, 2021View full label details → Warnings If you find out you are pregnant, please stop taking olmesartan medoxomil and hydrochlorothiazide tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. Make sure to correct any volume depletion before starting treatment. Your healthcare provider should regularly check your renal function and potassium levels if you are at risk. Be alert for any signs of fluid or electrolyte imbalance. Be aware that acute angle-closure glaucoma may occur. Sprue-like enteropathy has been reported. If no other cause is identified, consider discussing the discontinuation of olmesartan medoxomil and hydrochlorothiazide tablets with your healthcare provider. Pregnancy & Lactation Using drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal renal function and increase the risk of morbidity and death for both the fetus and neonate. Once you confirm your pregnancy, please discontinue olmesartan medoxomil and hydrochlorothiazide tablets as soon as possible. If there is no suitable alternative to therapy with drugs affecting the renin-angiotensin system for your specific situation, make sure to discuss the potential risks to your fetus with your healthcare provider. If oligohydramnios is observed, you should stop taking olmesartan medoxomil and hydrochlorothiazide tablets, unless your healthcare provider considers it lifesaving for you. Your healthcare provider should closely monitor infants with a history of in utero exposure to olmesartan medoxomil and hydrochlorothiazide tablets for signs of hypotension, oliguria, and hyperkalemia. It is not known whether olmesartan is excreted in human milk, but it is secreted at low concentrations in the milk of lactating rats. Due to the potential for adverse effects on your nursing infant, you should decide whether to continue nursing or to stop taking olmesartan medoxomil and hydrochlorothiazide tablets, considering the importance of the medication for your health. Side Effects You may experience nausea. You might have hyperuricemia. Dizziness can occur. An upper respiratory infection may develop. You could experience hypotension. Your healthcare provider should monitor you for acute angle-closure glaucoma. Sprue-like enteropathy is a possible side effect. Warnings when pregnancy is detected, discontinue olmesartan medoxomil and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume-depletion prior to administration monitor renal function and potassium in susceptible patients observe for signs of fluid or electrolyte imbalance acute angle-closure glaucoma sprue-like enteropathy has been reported. consider discontinuation of olmesartan medoxomil and hydrochlorothiazide tablets in cases where no other etiology is found Pregnancy & Lactation No pregnancy & lactation warnings reported. Side Effects nausea hyperuricemia dizziness upper respiratory infection hypotension acute angle-closure glaucoma sprue-like enteropathy
Olmesartan Medoxomil and Hydrochlorothiazide Rx tablet Alembic Pharmaceuticals Inc.	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	10 pregnancy and lactation warnings	7 side effects	Trend: was flat over 11 months; peaks in Jun, Aug, Sep, Oct, Nov, Dec.
Olmesartan Medoxomil and Hydrochlorothiazide® · First marketed 2017 · Label last revised June 25, 2025View full label details → Warnings If you find out you are pregnant, please stop taking olmesartan medoxomil and hydrochlorothiazide as soon as possible. Be aware that medications affecting the renin-angiotensin system can harm the developing fetus and may lead to serious complications. Make sure to correct any volume depletion before starting treatment. Your healthcare provider should regularly check your renal function and potassium levels if you are at risk. Keep an eye out for any signs of fluid or electrolyte imbalance. Be cautious of acute angle-closure glaucoma. Sprue-like enteropathy has been reported. If no other cause is identified, consider discussing the discontinuation of olmesartan medoxomil and hydrochlorothiazide tablets with your healthcare provider. Pregnancy & Lactation This medication can cause harm to the fetus if you are pregnant. Using drugs that affect the renin-angiotensin system during the second and third trimesters of your pregnancy may reduce your baby's kidney function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please stop taking Olmesartan medoxomil and hydrochlorothiazide tablets as soon as possible. Consider alternative antihypertensive treatments during your pregnancy. Having high blood pressure during pregnancy raises your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for your baby, including issues like intrauterine growth restriction and intrauterine death. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can lead to oligohydramnios, which may result in reduced kidney function for your baby, potentially causing anuria, renal failure, underdeveloped lungs, skeletal deformities, low blood pressure, and even death. Taking thiazides during pregnancy is linked to a risk of jaundice or low platelet counts in your baby. Thiazides should not be used to manage high blood pressure in pregnant women. It is not recommended to breastfeed while you are being treated with olmesartan medoxomil and hydrochlorothiazide tablets. Side Effects You may experience nausea. You might have hyperuricemia. Dizziness can occur. An upper respiratory infection may develop. You could experience hypotension. Your healthcare provider should monitor you for acute angle-closure glaucoma. Sprue-like enteropathy is a possible side effect. Warnings when pregnancy is detected, discontinue olmesartan medoxomil and hydrochlorothiazide as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume-depletion prior to administration monitor renal function and potassium in susceptible patients observe for signs of fluid or electrolyte imbalance acute angle-closure glaucoma sprue-like enteropathy has been reported. consider discontinuation of olmesartan medoxomil and hydrochlorothiazide tablets in cases where no other etiology is found Pregnancy & Lactation can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue Olmesartan medoxomil and hydrochlorothiazide tablets as soon as possible use alternative antihypertensive therapy during pregnancy hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death oligohydramnios in pregnant women who use drugs affecting the renin-angiotensin system in the second and third trimesters of pregnancy can result in reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia thiazides should not be used to treat hypertension in pregnant women breastfeeding is not recommended during treatment with olmesartan medoxomil and hydrochlorothiazide tablets Side Effects nausea hyperuricemia dizziness upper respiratory infection hypotension acute angle-closure glaucoma sprue-like enteropathy
Olmesartan Medoxomil and Hydrochlorothiazide Rx tablet, film coated Camber Pharmaceuticals, Inc.	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	10 pregnancy and lactation warnings	8 side effects	Trend: was flat over 11 months; peaks in Jun, Aug, Sep, Oct, Nov, Dec.
Olmesartan Medoxomil and Hydrochlorothiazide® · First marketed 2025 · Label last revised August 26, 2025View full label details → Warnings If you find out you are pregnant, please stop taking olmesartan medoxomil and hydrochlorothiazide tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. Make sure to correct any volume depletion before starting treatment. Your healthcare provider should monitor your renal function and potassium levels if you are at risk. Be aware of any signs of fluid or electrolyte imbalance. Watch for symptoms of acute angle-closure glaucoma. Sprue-like enteropathy has been reported. If no other cause is identified, consider discussing the discontinuation of olmesartan medoxomil and hydrochlorothiazide with your healthcare provider. Pregnancy & Lactation Olmesartan medoxomil and hydrochlorothiazide tablets can cause harm to your fetus if you are pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce your fetus's renal function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please stop taking olmesartan medoxomil and hydrochlorothiazide tablets as soon as possible. Having high blood pressure during pregnancy raises your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for your fetus of intrauterine growth restriction and intrauterine death. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can lead to oligohydramnios, which may result in reduced renal function in your fetus, potentially causing anuria, renal failure, lung development issues, skeletal deformities, low blood pressure, and even death. Thiazides can cross the placenta, and the levels in the umbilical vein can be similar to those in your bloodstream. Taking thiazides during pregnancy may increase the risk of jaundice or low platelet counts in your baby. It's best to avoid using hydrochlorothiazide for other conditions while you are pregnant. Breastfeeding is not recommended while you are being treated with olmesartan medoxomil and hydrochlorothiazide. Side Effects You may experience nausea. You might have hyperuricemia. Dizziness can occur. An upper respiratory infection may develop. You could experience hypotension. There may be a fluid or electrolyte imbalance. Your healthcare provider should monitor you for acute angle-closure glaucoma. Sprue-like enteropathy is a possible side effect. Warnings when pregnancy is detected, discontinue olmesartan medoxomil and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume-depletion prior to administration monitor renal function and potassium in susceptible patients observe for signs of fluid or electrolyte imbalance acute angle-closure glaucoma sprue-like enteropathy has been reported. consider discontinuation of olmesartan medoxomil and hydrochlorothiazide in cases where no other etiology is found Pregnancy & Lactation olmesartan medoxomil and hydrochlorothiazide tablets can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue olmesartan medoxomil and hydrochlorothiazide tablets as soon as possible hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death oligohydramnios in pregnant women who use drugs affecting the renin-angiotensin system in the second and third trimesters of pregnancy can result in reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death thiazides can cross the placenta, and concentrations reached in the umbilical vein approach those in the maternal plasma use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia the use of hydrochlorothiazide for other indications in pregnancy should be avoided breastfeeding is not recommended during treatment with olmesartan medoxomil and hydrochlorothiazide Side Effects nausea hyperuricemia dizziness upper respiratory infection hypotension fluid or electrolyte imbalance acute angle-closure glaucoma sprue-like enteropathy
Olmesartan Medoxomil and Hydrochlorothiazide Rx tablet REMEDYREPACK INC.	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	10 pregnancy and lactation warnings	7 side effects	Trend: was flat over 11 months; peaks in Jun, Aug, Sep, Oct, Nov, Dec.
Olmesartan Medoxomil and Hydrochlorothiazide® · First marketed 2019 · Label last revised August 26, 2025View full label details → Warnings If you find out you are pregnant, please stop taking olmesartan medoxomil and hydrochlorothiazide as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. Make sure to correct any volume depletion before starting treatment. Your healthcare provider should regularly check your renal function and potassium levels if you are at risk. Be aware of any signs of fluid or electrolyte imbalance. Watch for symptoms of acute angle-closure glaucoma. Sprue-like enteropathy has been reported. If no other cause is identified, consider discussing the discontinuation of olmesartan medoxomil and hydrochlorothiazide tablets with your healthcare provider. Pregnancy & Lactation This medication can cause harm to the fetus if you are pregnant. Using drugs that affect the renin-angiotensin system during the second and third trimesters of your pregnancy may reduce fetal kidney function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please stop taking Olmesartan medoxomil and hydrochlorothiazide tablets as soon as possible. Consider alternative antihypertensive treatments during your pregnancy. Having high blood pressure during pregnancy raises your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for your baby, including issues like intrauterine growth restriction and intrauterine death. Using medications that affect the renin-angiotensin system in the second and third trimesters of pregnancy can lead to oligohydramnios, which may result in reduced kidney function in the fetus, potentially causing anuria, renal failure, underdeveloped lungs, skeletal deformities (including skull hypoplasia), low blood pressure, and even death. Taking thiazides during pregnancy is linked to a risk of jaundice or low platelet counts in your baby. Thiazides should not be used to manage high blood pressure in pregnant women. It is not recommended to breastfeed while you are being treated with olmesartan medoxomil and hydrochlorothiazide tablets. Side Effects You may experience nausea. You might have hyperuricemia. Dizziness can occur. An upper respiratory infection may develop. You could experience hypotension. Your healthcare provider should monitor you for acute angle-closure glaucoma. Sprue-like enteropathy is a possible side effect. Warnings when pregnancy is detected, discontinue olmesartan medoxomil and hydrochlorothiazide as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume-depletion prior to administration monitor renal function and potassium in susceptible patients observe for signs of fluid or electrolyte imbalance acute angle-closure glaucoma sprue-like enteropathy has been reported. consider discontinuation of olmesartan medoxomil and hydrochlorothiazide tablets in cases where no other etiology is found Pregnancy & Lactation can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue Olmesartan medoxomil and hydrochlorothiazide tablets as soon as possible use alternative antihypertensive therapy during pregnancy hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death oligohydramnios in pregnant women who use drugs affecting the renin-angiotensin system in the second and third trimesters of pregnancy can result in reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia thiazides should not be used to treat hypertension in pregnant women breastfeeding is not recommended during treatment with olmesartan medoxomil and hydrochlorothiazide tablets Side Effects nausea hyperuricemia dizziness upper respiratory infection hypotension acute angle-closure glaucoma sprue-like enteropathy
Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide Rx tablet, film coated Camber Pharmaceuticals, Inc.	Popularity – score 0 out of 100 (least-viewed drug)	9 warnings	11 pregnancy and lactation warnings	17 side effects	Trend: was flat over 11 months.
Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide® · First marketed 2025 · Label last revised January 5, 2026View full label details → Warnings If you find out you are pregnant, please stop taking olmesartan medoxomil, amlodipine, and hydrochlorothiazide tablets as soon as possible. Be aware that medications affecting the renin-angiotensin system can harm the developing fetus and may lead to serious complications. Make sure to correct any volume or salt depletion before starting treatment. Your healthcare provider should monitor your renal function and potassium levels if you are at risk. You may experience increased angina or myocardial infarction when starting or increasing the dosage of calcium channel blockers. Keep an eye out for any signs of fluid or electrolyte imbalance. There is a possibility of exacerbation or activation of systemic lupus erythematosus. Be cautious of acute angle-closure glaucoma. Sprue-like enteropathy has been reported. If no other cause is identified, consider discussing the discontinuation of olmesartan medoxomil, amlodipine, and hydrochlorothiazide with your healthcare provider. Pregnancy & Lactation Olmesartan medoxomil, amlodipine, and hydrochlorothiazide can cause harm to your fetus if you are pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce your baby's kidney function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please stop taking olmesartan medoxomil, amlodipine, and hydrochlorothiazide as soon as possible. You should consider alternative treatments for high blood pressure during your pregnancy. Having high blood pressure while pregnant increases your risk for conditions like pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for your baby, including issues like growth restriction and stillbirth. Using medications that affect the renin-angiotensin system during the second and third trimesters can lead to oligohydramnios, which may result in reduced kidney function for your baby, potentially causing serious issues like renal failure, underdeveloped lungs, skeletal deformities, low blood pressure, and even death. Thiazides can cross the placenta, and the levels in your baby's umbilical vein can be similar to those in your bloodstream. Taking thiazides during pregnancy may increase the risk of jaundice or low platelet counts in your baby. These medications should not be used to manage high blood pressure in pregnant women. It is not recommended to breastfeed while being treated with olmesartan medoxomil, amlodipine, and hydrochlorothiazide. Side Effects You may experience dizziness. You might notice peripheral edema. Headaches can occur. Fatigue is a possible side effect. You could develop nasopharyngitis. Muscle spasms may happen. Nausea is something to watch for. An upper respiratory tract infection could occur. Diarrhea might be a concern. You may experience a urinary tract infection. Joint swelling can happen. Hypotension is a potential side effect. If you are taking calcium channel blockers, be aware of increased angina or myocardial infarction when starting or increasing the dosage. Watch for signs of fluid or electrolyte imbalance. There may be an exacerbation or activation of systemic lupus erythematosus. Acute angle-closure glaucoma is a serious condition to be aware of. Sprue-like enteropathy may occur. Warnings when pregnancy is detected, discontinue olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume or salt depletion prior to administration monitor renal function and potassium in susceptible patients increased angina or myocardial infarction with calcium channel blockers may occur upon dosage initiation or increase observe for signs of fluid or electrolyte imbalance exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma sprue-like enteropathy has been reported. consider discontinuation of olmesartan medoxomil, amlodipine and hydrochlorothiazide in cases where no other etiology is found Pregnancy & Lactation olmesartan medoxomil, amlodipine and hydrochlorothiazide can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue olmesartan medoxomil, amlodipine and hydrochlorothiazide as soon as possible consider alternative antihypertensive therapy during pregnancy hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death oligohydramnios in pregnant women who use drugs affecting the renin-angiotensin system in the second and third trimesters of pregnancy can result in reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death thiazides can cross the placenta, and concentrations reached in the umbilical vein approach those in the maternal plasma use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia these drugs should not be used to treat hypertension in pregnant women breastfeeding is not recommended during treatment with olmesartan medoxomil, amlodipine and hydrochlorothiazide Side Effects dizziness peripheral edema headache fatigue nasopharyngitis muscle spasms nausea upper respiratory tract infection diarrhea urinary tract infection joint swelling hypotension increased angina or myocardial infarction with calcium channel blockers upon dosage initiation or increase signs of fluid or electrolyte imbalance exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma sprue-like enteropathy
Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide Rx tablet, film coated Teva Pharmaceuticals USA, Inc.	Popularity – score 0 out of 100 (least-viewed drug)	9 warnings	11 pregnancy and lactation warnings	17 side effects	Trend: was flat over 11 months.
Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide® · First marketed 2016 · Label last revised January 1, 2021View full label details → Warnings If you find out you are pregnant, please stop taking olmesartan medoxomil, amlodipine, and hydrochlorothiazide tablets as soon as possible. Be aware that medications affecting the renin-angiotensin system can harm the developing fetus and may lead to serious complications. Make sure to correct any volume or salt depletion before starting treatment. Your healthcare provider should monitor your renal function and potassium levels if you are at risk. You may experience increased angina or myocardial infarction when starting or increasing the dosage of calcium channel blockers. Keep an eye out for any signs of fluid or electrolyte imbalance. There is a possibility of exacerbation or activation of systemic lupus erythematosus. Be cautious of acute angle-closure glaucoma. Sprue-like enteropathy has been reported. If no other cause is identified, consider discussing the discontinuation of olmesartan medoxomil, amlodipine, and hydrochlorothiazide tablets with your healthcare provider. Pregnancy & Lactation Olmesartan medoxomil, amlodipine, and hydrochlorothiazide tablets can cause harm to the fetus if you take them while pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please stop taking olmesartan medoxomil, amlodipine, and hydrochlorothiazide tablets as soon as possible. You should consider alternative antihypertensive treatments during your pregnancy. Having high blood pressure during pregnancy raises your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for your baby of intrauterine growth restriction and intrauterine death. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can lead to oligohydramnios, which may result in reduced kidney function in the fetus, potentially causing anuria, renal failure, underdeveloped lungs, skeletal deformities (including skull hypoplasia), low blood pressure, and even death. Thiazides can cross the placenta, and the levels in the umbilical vein can be similar to those in your bloodstream. Taking thiazides during pregnancy is associated with a risk of jaundice or low platelet counts in your baby. You should avoid using HCTZ for other conditions during your pregnancy. Infants who were exposed to olmesartan in utero should be closely monitored for low blood pressure, reduced urine output, and high potassium levels. Side Effects You may experience dizziness. You might notice peripheral edema. Headaches can occur. Fatigue is a possible side effect. You could develop nasopharyngitis. Muscle spasms may happen. Nausea is something to watch for. An upper respiratory tract infection could occur. Diarrhea may be a side effect. You might experience a urinary tract infection. Joint swelling can happen. Hypotension is a potential concern. If you are taking calcium channel blockers, increased angina or myocardial infarction may occur when starting or increasing the dosage. Be aware of possible fluid or electrolyte imbalances. There may be an exacerbation or activation of systemic lupus erythematosus. Acute angle-closure glaucoma is a serious condition to monitor. Sprue-like enteropathy may occur. Warnings when pregnancy is detected, discontinue olmesartan medoxomil, amlodipine, and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume or salt depletion prior to administration monitor renal function and potassium in susceptible patients increased angina or myocardial infarction with calcium channel blockers may occur upon dosage initiation or increase observe for signs of fluid or electrolyte imbalance exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma sprue-like enteropathy has been reported. consider discontinuation of olmesartan medoxomil, amlodipine, and hydrochlorothiazide tablets in cases where no other etiology is found Pregnancy & Lactation olmesartan medoxomil, amlodipine, and hydrochlorothiazide tablets can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue olmesartan medoxomil, amlodipine, and hydrochlorothiazide tablets as soon as possible consider alternative antihypertensive therapy during pregnancy hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death oligohydramnios in pregnant women who use drugs affecting the renin-angiotensin system in the second and third trimesters of pregnancy can result in reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death thiazides can cross the placenta, and concentrations reached in the umbilical vein approach those in the maternal plasma use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia the use of HCTZ for other indications in pregnancy should be avoided closely observe infants with histories of in utero exposure to olmesartan for hypotension, oliguria, and hyperkalemia Side Effects dizziness peripheral edema headache fatigue nasopharyngitis muscle spasms nausea upper respiratory tract infection diarrhea urinary tract infection joint swelling hypotension increased angina or myocardial infarction with calcium channel blockers may occur upon dosage initiation or increase fluid or electrolyte imbalance exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma sprue-like enteropathy
Olmesartan Medoxomil-Hydrochlorothiazide Rx tablet, film coated Novadoz Pharmaceuticals LLC	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	10 pregnancy and lactation warnings	8 side effects	Trend: was flat over 11 months.
Olmesartan Medoxomil-Hydrochlorothiazide® · First marketed 2025 · Label last revised September 26, 2025View full label details → Warnings If you find out you are pregnant, please stop taking olmesartan medoxomil and hydrochlorothiazide as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. Make sure to correct any volume depletion before starting treatment. Your healthcare provider should regularly check your renal function and potassium levels if you are at risk. Be alert for any signs of fluid or electrolyte imbalance. Be aware that acute angle-closure glaucoma may occur. Sprue-like enteropathy has been reported. If no other cause is identified, consider discussing the discontinuation of olmesartan medoxomil and hydrochlorothiazide with your healthcare provider. Pregnancy & Lactation Olmesartan medoxomil and hydrochlorothiazide can cause harm to your fetus if you are pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of your pregnancy may reduce your fetus's renal function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please discontinue olmesartan medoxomil and hydrochlorothiazide as soon as possible. Consider alternative antihypertensive therapies during your pregnancy. Having hypertension during pregnancy raises your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. Hypertension can also increase the risk for your fetus, including intrauterine growth restriction and intrauterine death. If you are pregnant and using medications that affect the renin-angiotensin system during the second and third trimesters, oligohydramnios may occur, which can lead to reduced fetal renal function, anuria, renal failure, fetal lung hypoplasia, skeletal deformations such as skull hypoplasia, hypotension, and even death. Thiazides can cross the placenta, and the concentrations in the umbilical vein can be similar to those in your plasma. Using thiazides during pregnancy may be associated with a risk of fetal or neonatal jaundice or thrombocytopenia. It is advisable to avoid using hydrochlorothiazide for other indications during your pregnancy. Side Effects You may experience nausea. You might have hyperuricemia. Dizziness can occur. An upper respiratory infection may develop. You could experience hypotension. There may be a fluid or electrolyte imbalance. Your healthcare provider should monitor you for acute angle-closure glaucoma. Sprue-like enteropathy is a possible side effect. Warnings when pregnancy is detected, discontinue olmesartan medoxomil and hydrochlorothiazide as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume-depletion prior to administration monitor renal function and potassium in susceptible patients observe for signs of fluid or electrolyte imbalance acute angle-closure glaucoma sprue-like enteropathy has been reported. consider discontinuation of olmesartan medoxomil and hydrochlorothiazide in cases where no other etiology is found Pregnancy & Lactation olmesartan medoxomil and hydrochlorothiazide can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue olmesartan medoxomil and hydrochlorothiazide as soon as possible use alternative antihypertensive therapy during pregnancy hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death oligohydramnios in pregnant women who use drugs affecting the renin-angiotensin system in the second and third trimesters of pregnancy can result in reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death thiazides can cross the placenta, and concentrations reached in the umbilical vein approach those in the maternal plasma use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia the use of hydrochlorothiazide for other indications in pregnancy should be avoided Side Effects nausea hyperuricemia dizziness upper respiratory infection hypotension fluid or electrolyte imbalance acute angle-closure glaucoma sprue-like enteropathy
Quinapril and Hydrochlorothiazide Rx tablet Chartwell RX, LLC	Popularity – score 0 out of 100 (least-viewed drug)	27 warnings	0 pregnancy and lactation warnings	105 side effects	Trend: fell 50% over the year; peaks in Feb, Dec.
Quinapril and Hydrochlorothiazide® · First marketed 2004 · Label last revised December 11, 2023View full label details → Warnings If you find out you are pregnant, please stop taking quinapril and hydrochlorothiazide tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. Angioedema affecting the face, extremities, lips, tongue, glottis, and larynx has been reported in patients treated with ACE inhibitors. If you experience laryngeal stridor or angioedema of the face, tongue, or glottis, you should stop taking quinapril and hydrochlorothiazide tablets immediately. If you are taking mTOR inhibitors or a neprilysin inhibitor, you may have an increased risk of angioedema. Intestinal angioedema has been reported in patients treated with ACE inhibitors. If you have a history of angioedema not related to ACE inhibitor therapy, you may be at a higher risk of angioedema while taking an ACE inhibitor. If you develop jaundice or significant increases in liver enzymes while on ACE inhibitors, you should discontinue the ACE inhibitor and seek appropriate medical follow-up. Quinapril and hydrochlorothiazide tablets can cause low blood pressure symptoms. Make sure to correct any volume and/or salt depletion before starting therapy with quinapril and hydrochlorothiazide tablets. Use quinapril and hydrochlorothiazide tablets cautiously if you are also taking other antihypertensive medications. If you are at risk of excessive low blood pressure, start therapy with quinapril and hydrochlorothiazide tablets under close medical supervision. If you experience excessive low blood pressure, you should lie down and receive treatment with an intravenous infusion of normal saline. Use quinapril and hydrochlorothiazide tablets with caution if you have severe renal disease. Your evaluation as a hypertensive patient should include an assessment of your renal function. Consider periodic monitoring of white blood cell counts if you have collagen vascular disease and/or renal disease. If you are taking quinapril and hydrochlorothiazide tablets, please report any signs or symptoms of angioedema immediately. If you are a female patient of childbearing age, be aware of the potential consequences of taking quinapril and hydrochlorothiazide tablets during pregnancy. You may experience lightheadedness while taking quinapril and hydrochlorothiazide tablets, especially during the first few days of therapy. Inadequate fluid intake, excessive sweating, diarrhea, or vomiting can lead to a significant drop in blood pressure, so be mindful of these factors. Do not use potassium supplements or salt substitutes containing potassium without consulting your prescribing physician while taking quinapril and hydrochlorothiazide tablets. Please report any signs of infection promptly, as they could indicate neutropenia. If you are taking hydrochlorothiazide, protect your skin from the sun and have regular skin cancer screenings. Since quinapril and hydrochlorothiazide are present in human milk, exercise caution when these tablets are given to a nursing woman. A decision should be made about whether to continue nursing or to stop taking quinapril and hydrochlorothiazide tablets, considering the importance of the medication to you. Clinical studies of quinapril HCl/hydrochlorothiazide did not include enough participants aged 65 and over to determine if they respond differently than younger individuals. The safety and effectiveness of quinapril and hydrochlorothiazide tablets in children have not been established. Pregnancy & Lactation If you are a female of childbearing age, it's important to understand the potential consequences of exposure to quinapril and hydrochlorothiazide tablets during pregnancy. If you are planning to become pregnant, please discuss your treatment options with your healthcare provider. Be sure to report any pregnancies to your physician as soon as possible. Side Effects You may experience a cough (1.0%). You might have a headache (0.7%). You could experience a headache (6.7%). You may feel dizziness (4.8%). You might notice coughing (3.2%). You could feel fatigue (2.9%). You may experience myalgia (2.4%). You might develop a viral infection (1.9%). You could have rhinitis (2.0%). You may experience nausea and/or vomiting (1.8%). You might feel abdominal pain (1.7%). You could have back pain (1.5%). You may experience diarrhea (1.4%). You might develop an upper respiratory infection (1.3%). You could have insomnia (1.2%). You may feel somnolence (1.2%). You might develop bronchitis (1.2%). You could experience dyspepsia (1.2%). You may feel asthenia (1.1%). You might have pharyngitis (1.1%). You could experience vasodilatation (1.0%). You may feel vertigo (1.0%). You might experience chest pain (1.0%). You could experience shock. You may be at risk for accidental injury. You might develop a neoplasm. You could experience cellulitis. You may have ascites. You might experience generalized edema. You could develop a hernia. You may have an anaphylactoid reaction. You might experience bradycardia. You could develop cor pulmonale. You may experience vasculitis. You might be at risk for deep vein thrombosis. You could develop gastrointestinal carcinoma. You may experience cholestatic jaundice. You might have hepatitis. You could develop esophagitis. You may experience vomiting. You might have diarrhea. You could experience cramping. You may feel nausea. You might experience gastric irritation. You could have constipation. You may experience anorexia. You might feel lightheaded. You could experience transient blurred vision. You may have paresthesia. You might experience xanthopsia. You could feel weakness. You may experience restlessness. You might have muscle spasms. You could develop aplastic anemia. You may experience agranulocytosis. You might have leukopenia. You could develop thrombocytopenia. You may experience hemolytic anemia. You might have renal failure. You could experience renal dysfunction. You may develop interstitial nephritis. You might experience hyperglycemia. You could have glycosuria. You may experience hyperuricemia. You might develop necrotizing angiitis. You could experience Stevens-Johnson syndrome. You may have respiratory distress. You might develop purpura. You could experience urticaria. You may have a rash. You might experience photosensitivity. You could develop acute myopia. You may be at risk for acute angle closure glaucoma. You might experience anemia. You could have weight loss. You may develop myopathy. You might experience myositis. You could develop arthritis. You may experience paralysis. You might have hemiplegia. You could develop a speech disorder. You may have an abnormal gait. You might experience meningism. You could have amnesia. You may develop pneumonia. You might have asthma. You could experience respiratory infiltration. You may have a lung disorder. You might develop urticaria. You could have a macropapular rash. You may experience petechiases. You might have kidney function abnormalities. You could experience albuminuria. You may have pyuria. You might experience hematuria. You could develop nephrosis. You may experience depression. You might have constipation. You could experience syncope. You may develop amblyopia. You might experience hypotension. You could have impaired renal function. You may experience acute renal failure. You might develop intestinal angioedema. You could experience hypotension (1.2%). Warnings when pregnancy is detected, discontinue quinapril and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus angioedema of the face, extremities, lips, tongue, glottis, and larynx has been reported in patients treated with ACE inhibitors if laryngeal stridor or angioedema of the face, tongue, or glottis occurs, treatment with quinapril and hydrochlorothiazide tablets should be discontinued immediately patients taking concomitant mTOR inhibitor therapy or a neprilysin inhibitor may be at increased risk for angioedema intestinal angioedema has been reported in patients treated with ACE inhibitors patients with a history of angioedema unrelated to ACE inhibitor therapy may be at increased risk of angioedema while receiving an ACE inhibitor patients receiving ACE inhibitors who develop jaundice or marked elevations of hepatic enzymes should discontinue the ACE inhibitor and receive appropriate medical follow-up quinapril and hydrochlorothiazide tablets can cause symptomatic hypotension volume and/or salt depletion should be corrected before initiating therapy with quinapril and hydrochlorothiazide tablets quinapril and hydrochlorothiazide tablets should be used cautiously in patients receiving concomitant therapy with other antihypertensives in patients at risk of excessive hypotension, therapy with quinapril and hydrochlorothiazide tablets should be started under close medical supervision if excessive hypotension occurs, the patient should be placed in a supine position and treated with intravenous infusion of normal saline quinapril and hydrochlorothiazide tablets should be used with caution in patients with severe renal disease evaluation of the hypertensive patients should also include assessment of the renal function periodic monitoring of white blood cell counts in patients with collagen vascular disease and/or renal disease should be considered tell patients receiving quinapril and hydrochlorothiazide tablets to immediately report any signs or symptoms suggesting angioedema tell female patients of childbearing age about the consequences of exposure to quinapril and hydrochlorothiazide tablets during pregnancy tell patients receiving quinapril and hydrochlorothiazide tablets that lightheadedness can occur, especially during the first days of therapy tell patients that inadequate fluid intake, excessive perspiration, diarrhea, or vomiting can lead to an excessive fall in blood pressure tell patients receiving quinapril and hydrochlorothiazide tablets not to use potassium supplements or salt substitutes containing potassium without consulting the prescribing physician tell patients to promptly report any indication of infection which could be a sign of neutropenia instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening because quinapril and hydrochlorothiazide are secreted in human milk, caution should be exercised when quinapril and hydrochlorothiazide tablets are administered to a nursing woman a decision should be made whether to discontinue nursing or to discontinue quinapril and hydrochlorothiazide tablets, taking into account the importance of the drug to the mother clinical studies of quinapril HCl/hydrochlorothiazide did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects safety and effectiveness of quinapril and hydrochlorothiazide tablets in children have not been established Pregnancy & Lactation No pregnancy & lactation warnings reported. Side Effects cough (1.0%) headache (0.7%) headache (6.7%) dizziness (4.8%) coughing (3.2%) fatigue (2.9%) myalgia (2.4%) viral infection (1.9%) rhinitis (2.0%) nausea and/or vomiting (1.8%) abdominal pain (1.7%) back pain (1.5%) diarrhea (1.4%) upper respiratory infection (1.3%) insomnia (1.2%) somnolence (1.2%) bronchitis (1.2%) dyspepsia (1.2%) asthenia (1.1%) pharyngitis (1.1%) vasodilatation (1.0%) vertigo (1.0%) chest pain (1.0%) shock accidental injury neoplasm cellulitis ascites generalized edema hernia anaphylactoid reaction bradycardia cor pulmonale vasculitis deep vein thrombosis gastrointestinal carcinoma cholestatic jaundice hepatitis esophagitis vomiting diarrhea cramping nausea gastric irritation constipation anorexia lightheadedness transient blurred vision paresthesia xanthopsia weakness restlessness muscle spasm aplastic anemia agranulocytosis leukopenia thrombocytopenia hemolytic anemia renal failure renal dysfunction interstitial nephritis hyperglycemia glycosuria hyperuricemia necrotizing angiitis Stevens-Johnson syndrome respiratory distress purpura urticaria rash photosensitivity acute myopia acute angle closure glaucoma anemia weight loss myopathy myositis arthritis paralysis hemiplegia speech disorder abnormal gait meningism amnesia pneumonia asthma respiratory infiltration lung disorder urticaria macropapular rash petechiases kidney function abnormal albuminuria pyuria hematuria nephrosis depression constipation syncope amblyopia hypotension impaired renal function acute renal failure intestinal angioedema hypotension (1.2%)
Quinapril and Hydrochlorothiazide 10/12.5, Quinapril and Hydrochlorothiazide 20/12.5, Quinapril and Hydrochlorothiazide… Rx tablet Cipla USA Inc.	Popularity – score 0 out of 100 (least-viewed drug)	35 warnings	0 pregnancy and lactation warnings	59 side effects	Trend: was flat over 11 months.
Quinapril and Hydrochlorothiazide 10/12.5, Quinapril and Hydrochlorothiazide 20/12.5, Quinapril and Hydrochlorothiazide 20/25® · First marketed 2016 · Label last revised January 7, 2022View full label details → Warnings If you find out you are pregnant, please stop taking quinapril and hydrochlorothiazide tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. Angioedema affecting the face, extremities, lips, tongue, glottis, and larynx has been reported in patients treated with ACE inhibitors. If you experience laryngeal stridor or angioedema of the face, tongue, or glottis, stop taking quinapril and hydrochlorothiazide tablets immediately. If you are taking mTOR inhibitors or neprilysin inhibitors, be aware that you may have an increased risk of angioedema. Intestinal angioedema has been reported in patients treated with ACE inhibitors. If you have a history of angioedema unrelated to ACE inhibitor therapy, you may be at a higher risk of angioedema while taking an ACE inhibitor. Patients undergoing desensitization treatment with Hymenoptera venom while on ACE inhibitors have experienced life-threatening anaphylactoid reactions. Patients who are dialyzed with high-flux membranes and treated with an ACE inhibitor have reported anaphylactoid reactions. If you are taking ACE inhibitors and develop jaundice or significant increases in liver enzymes, please stop the ACE inhibitor and seek appropriate medical follow-up. Quinapril and hydrochlorothiazide tablets can cause low blood pressure symptoms. Make sure to correct any volume and/or salt depletion before starting therapy with quinapril and hydrochlorothiazide tablets. Use quinapril and hydrochlorothiazide tablets cautiously if you are also taking other antihypertensive medications. If you are at risk for excessive low blood pressure, start therapy with quinapril and hydrochlorothiazide tablets under close medical supervision. If you experience excessive low blood pressure, lie down and receive treatment with an intravenous infusion of normal saline. Use quinapril and hydrochlorothiazide tablets with caution if you have severe kidney disease. When quinapril inhibits the renin-angiotensin-aldosterone system, changes in kidney function may occur in susceptible individuals. Your kidney function should be monitored during the first few weeks of therapy with quinapril and hydrochlorothiazide tablets. You may need a dosage reduction of quinapril and hydrochlorothiazide tablets if you have pre-existing kidney impairment. Consider periodic monitoring of white blood cell counts if you have collagen vascular disease and/or kidney disease. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase risks for the fetus and newborn. If there is no suitable alternative to medications affecting the renin-angiotensin system for your treatment, discuss the potential risks to your fetus with your healthcare provider. Be aware that oligohydramnios may not be detected until after the fetus has sustained irreversible injury. Use quinapril and hydrochlorothiazide tablets cautiously if you have impaired liver function or progressive liver disease. Thiazide diuretics can worsen or activate systemic lupus erythematosus. Hydrochlorothiazide may cause an unusual reaction that leads to acute angle-closure glaucoma and increased intraocular pressure. If you are taking quinapril and hydrochlorothiazide tablets, please report any signs or symptoms of angioedema to your healthcare provider right away. If you are a female of childbearing age, be informed about the risks of taking quinapril and hydrochlorothiazide tablets during pregnancy. If you are taking quinapril and hydrochlorothiazide tablets, be aware that lightheadedness can occur, especially during the first few days of treatment. Inadequate fluid intake, excessive sweating, diarrhea, or vomiting can lead to a significant drop in blood pressure, so please stay hydrated. If you are taking quinapril and hydrochlorothiazide tablets, avoid using potassium supplements or salt substitutes containing potassium without consulting your prescribing physician. Please report any signs of infection to your healthcare provider, as this could indicate neutropenia. If you are taking hydrochlorothiazide, protect your skin from the sun and schedule regular skin cancer screenings. Therapy with quinapril and hydrochlorothiazide tablets should be paused for a few days before any tests of parathyroid function. If you are taking mTOR inhibitors or neprilysin inhibitors, be aware that you may have an increased risk of angioedema. Pregnancy & Lactation If you find out you are pregnant, please stop taking quinapril and hydrochlorothiazide tablets as soon as possible. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase the risk of complications for both the fetus and newborn. Oligohydramnios, or low amniotic fluid, can lead to issues such as underdeveloped lungs and skeletal deformities in the fetus. Potential adverse effects for newborns may include skull hypoplasia, lack of urine production, low blood pressure, kidney failure, and even death. If there are no suitable alternatives to medications affecting the renin-angiotensin system for your treatment, please discuss the potential risks to your fetus with your healthcare provider. Your healthcare provider may perform serial ultrasound examinations to monitor the intra-amniotic environment. If oligohydramnios is detected, you should stop taking quinapril and hydrochlorothiazide tablets, unless your healthcare provider determines it is essential for your health. Infants who were exposed to quinapril and hydrochlorothiazide tablets in utero should be closely monitored for low blood pressure, reduced urine output, and high potassium levels. Since quinapril and hydrochlorothiazide can pass into breast milk, please use caution if you are a nursing mother taking these medications. You and your healthcare provider should decide whether to continue nursing or to stop taking quinapril and hydrochlorothiazide tablets, considering how important the medication is for your health. Side Effects You may experience a cough (1.0%). You might have a headache (0.7%). Shock is a potential risk. Be aware of the possibility of accidental injury. Neoplasm could occur. Cellulitis is a potential side effect. Ascites may develop. You could experience generalized edema. Hernia is a possible concern. An anaphylactoid reaction may happen. Bradycardia could occur. Cor pulmonale is a potential risk. Vasculitis may develop. Deep vein thrombosis is a possibility. Gastrointestinal carcinoma could occur. Cholestatic jaundice may happen. Hepatitis is a potential side effect. Esophagitis could occur. You might experience vomiting. Diarrhea is a possible side effect. Acute myopia may develop. Acute angle closure glaucoma is a risk, with or without acute myopia and choroidal effusions. Anemia could occur. Weight loss may happen. Myopathy is a potential concern. Myositis could develop. Arthritis is a possible side effect. Paralysis may occur. Hemiplegia is a potential risk. You might experience a speech disorder. Abnormal gait could develop. Meningism is a possibility. Amnesia may occur. Pneumonia is a potential risk. Asthma could develop. Respiratory infiltration may happen. Lung disorder is a possible concern. Urticaria may occur. You might experience a macropapular rash. Petechiases could develop. Abnormal vision is a potential side effect. You may have abnormal kidney function. Albuminuria could occur. Pyuria is a possibility. Hematuria may develop. Nephrosis is a potential concern. Depression could occur. You might experience back pain. Constipation is a possible side effect. Syncope may happen. Amblyopia could develop. Angioedema of the face, extremities, lips, tongue, glottis, and larynx is a potential risk. Intestinal angioedema may occur. Hypotension is a possible concern. Impaired renal function could develop. Neutropenia is a potential risk. Agranulocytosis may occur. Exacerbation or activation of systemic lupus erythematosus is a possibility. Warnings when pregnancy is detected, discontinue quinapril and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus angioedema of the face, extremities, lips, tongue, glottis, and larynx has been reported in patients treated with ACE inhibitors if laryngeal stridor or angioedema of the face, tongue, or glottis occurs, treatment with quinapril and hydrochlorothiazide tablets should be discontinued immediately patients taking concomitant mTOR inhibitor therapy or a neprilysin inhibitor may be at increased risk for angioedema intestinal angioedema has been reported in patients treated with ACE inhibitors patients with a history of angioedema unrelated to ACE inhibitor therapy may be at increased risk of angioedema while receiving an ACE inhibitor patients undergoing desensitizing treatment with Hymenoptera venom while receiving ACE inhibitors sustained life-threatening anaphylactoid reactions patients dialyzed with high-flux membranes and treated concomitantly with an ACE inhibitor have reported anaphylactoid reactions patients receiving ACE inhibitors who develop jaundice or marked elevations of hepatic enzymes should discontinue the ACE inhibitor and receive appropriate medical follow-up quinapril and hydrochlorothiazide tablets can cause symptomatic hypotension volume and/or salt depletion should be corrected before initiating therapy with quinapril and hydrochlorothiazide tablets quinapril and hydrochlorothiazide tablets should be used cautiously in patients receiving concomitant therapy with other antihypertensives in patients at risk of excessive hypotension, therapy with quinapril and hydrochlorothiazide tablets should be started under close medical supervision if excessive hypotension occurs, the patient should be placed in a supine position and treated with intravenous infusion of normal saline quinapril and hydrochlorothiazide tablets should be used with caution in patients with severe renal disease when the renin-angiotensin-aldosterone system is inhibited by quinapril, changes in renal function may be anticipated in susceptible individuals renal function should be monitored during the first few weeks of therapy in patients treated with quinapril and hydrochlorothiazide tablets dosage reduction of quinapril and hydrochlorothiazide tablets may be required in patients with pre-existing renal impairment periodic monitoring of white blood cell counts in patients with collagen vascular disease and/or renal disease should be considered use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death in the unusual case that there is no appropriate alternative to therapy with drugs affecting the renin-angiotensin system for a particular patient, apprise the mother of the potential risk to the fetus patients and physicians should be aware that oligohydramnios may not appear until after the fetus has sustained irreversible injury quinapril and hydrochlorothiazide tablets should be used with caution in patients with impaired hepatic function or progressive liver disease thiazide diuretics have been reported to cause exacerbation or activation of systemic lupus erythematosus hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute angle-closure glaucoma and elevated intraocular pressure tell patients receiving quinapril and hydrochlorothiazide tablets to immediately report any signs or symptoms suggesting angioedema tell female patients of childbearing age about the consequences of exposure to quinapril and hydrochlorothiazide tablets during pregnancy tell patients receiving quinapril and hydrochlorothiazide tablets that lightheadedness can occur, especially during the first days of therapy tell patients that inadequate fluid intake, excessive perspiration, diarrhea, or vomiting can lead to an excessive fall in blood pressure tell patients receiving quinapril and hydrochlorothiazide tablets not to use potassium supplements or salt substitutes containing potassium without consulting the prescribing physician tell patients to promptly report any indication of infection which could be a sign of neutropenia instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening therapy with quinapril and hydrochlorothiazide tablets should be interrupted for a few days before carrying out tests of parathyroid function patients taking concomitant mTOR inhibitor therapy or a neprilysin inhibitor may be at increased risk for angioedema Pregnancy & Lactation No pregnancy & lactation warnings reported. Side Effects cough (1.0%) headache (0.7%) shock accidental injury neoplasm cellulitis ascites generalized edema hernia anaphylactoid reaction bradycardia cor pulmonale vasculitis deep vein thrombosis gastrointestinal carcinoma cholestatic jaundice hepatitis esophagitis vomiting diarrhea acute myopia acute angle closure glaucoma anemia weight loss myopathy myositis arthritis paralysis hemiplegia speech disorder abnormal gait meningism amnesia pneumonia asthma respiratory infiltration lung disorder urticaria macropapular rash petechiases abnormal vision kidney function abnormal albuminuria pyuria hematuria nephrosis depression back pain constipation syncope amblyopia angioedema of the face, extremities, lips, tongue, glottis, and larynx intestinal angioedema hypotension impaired renal function neutropenia agranulocytosis exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma with or without acute myopia and choroidal effusions
Quinapril Hcl and Hydrochlorothiazide Rx tablet Lupin Pharmaceuticals, Inc.	Popularity – score 0 out of 100 (least-viewed drug)	41 warnings	0 pregnancy and lactation warnings	107 side effects	Trend: was flat over 11 months.
Quinapril Hcl and Hydrochlorothiazide® · First marketed 2011 · Label last revised January 30, 2024View full label details → Warnings If you detect that you are pregnant, please discontinue Quinapril and Hydrochlorothiazide Tablets as soon as possible. Medications that act directly on the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. Angioedema affecting the face, extremities, lips, tongue, glottis, and larynx has been reported in patients treated with ACE inhibitors. If you experience laryngeal stridor or angioedema of the face, tongue, or glottis, stop taking Quinapril and Hydrochlorothiazide Tablets immediately. If you are taking mTOR inhibitors or neprilysin inhibitors, be aware that you may be at a higher risk for angioedema. Intestinal angioedema has been reported in patients treated with ACE inhibitors. If you have a history of angioedema unrelated to ACE inhibitor therapy, you may be at increased risk of angioedema while receiving an ACE inhibitor. Two patients undergoing desensitization treatment with Hymenoptera venom while on ACE inhibitors experienced life-threatening anaphylactoid reactions. Anaphylactoid reactions have been reported in patients who were dialyzed with high-flux membranes and treated with an ACE inhibitor at the same time. If you are receiving ACE inhibitors and develop jaundice or significant elevations in hepatic enzymes, you should stop the ACE inhibitor and seek appropriate medical follow-up. Quinapril and Hydrochlorothiazide Tablets can cause symptomatic hypotension. Make sure to correct any volume and/or salt depletion before starting therapy with Quinapril and Hydrochlorothiazide Tablets. Use Quinapril and Hydrochlorothiazide Tablets cautiously if you are also taking other antihypertensive medications. If you are at risk of excessive hypotension, your therapy with Quinapril and Hydrochlorothiazide Tablets should begin under close medical supervision. If you experience excessive hypotension, you should lie down and receive treatment with an intravenous infusion of normal saline. Use Quinapril and Hydrochlorothiazide Tablets with caution if you have severe renal disease. When Quinapril inhibits the renin-angiotensin-aldosterone system, changes in renal function may occur in susceptible individuals. Your renal function should be monitored during the first few weeks of therapy. You may need a dosage reduction of Quinapril and Hydrochlorothiazide Tablets if you have pre-existing renal impairment. Consider periodic monitoring of white blood cell counts if you have collagen vascular disease and/or renal disease. Using drugs that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal renal function and increase the risk of fetal and neonatal morbidity and death. If there is no suitable alternative to therapy with drugs affecting the renin-angiotensin system for you, please discuss the potential risks to your fetus with your healthcare provider. Be aware that oligohydramnios may not be evident until after the fetus has sustained irreversible injury. Use Quinapril and Hydrochlorothiazide Tablets with caution if you have impaired hepatic function or progressive liver disease. Thiazide diuretics have been known to exacerbate or activate systemic lupus erythematosus. Hydrochlorothiazide can cause an idiosyncratic reaction, leading to acute angle closure glaucoma and elevated intraocular pressure. If you are taking Quinapril and Hydrochlorothiazide Tablets, please report any signs or symptoms of angioedema to your healthcare provider immediately. If you are a female patient of childbearing age, be informed about the consequences of exposure to Quinapril and Hydrochlorothiazide Tablets during pregnancy. If you are taking Quinapril and Hydrochlorothiazide Tablets, be aware that lightheadedness can occur, especially during the first few days of therapy. Inadequate fluid intake, excessive sweating, diarrhea, or vomiting can lead to a significant drop in blood pressure, so please stay hydrated. If you are taking Quinapril and Hydrochlorothiazide Tablets, avoid using potassium supplements or salt substitutes containing potassium without consulting your prescribing physician. Promptly report any signs of infection, as they could indicate neutropenia. If you are taking hydrochlorothiazide, protect your skin from the sun and consider regular skin cancer screenings. You should interrupt therapy with Quinapril and Hydrochlorothiazide Tablets for a few days before undergoing tests of parathyroid function. Your healthcare provider should monitor serum potassium levels if you are taking Quinapril and Hydrochlorothiazide Tablets alongside other medications that raise potassium levels. Caution is advised when coadministering Quinapril and Hydrochlorothiazide Tablets with lithium, and frequent monitoring of serum lithium levels is recommended. Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren can increase the risks of hypotension, hyperkalemia, and changes in renal function. Do not take aliskiren with Quinapril and Hydrochlorothiazide Tablets if you have diabetes. Exercise caution when administering Quinapril and Hydrochlorothiazide Tablets to a nursing woman. A decision should be made whether to stop nursing or to discontinue Quinapril and Hydrochlorothiazide Tablets, considering the importance of the medication to the mother. If you experience oliguria or hypotension, focus on supporting your blood pressure and renal perfusion. Pregnancy & Lactation If you detect that you are pregnant, please discontinue Quinapril and Hydrochlorothiazide Tablets as soon as possible. Using drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal renal function and increase the risk of morbidity and mortality for both the fetus and newborn. It's important to manage maternal hypertension during pregnancy effectively to optimize outcomes for both you and your baby. In the rare case that there is no suitable alternative to therapy with drugs affecting the renin-angiotensin system for your situation, please discuss the potential risks to your fetus with your healthcare provider. Your healthcare provider may perform serial ultrasound examinations to assess the intra-amniotic environment. If oligohydramnios is observed, you should discontinue Quinapril and Hydrochlorothiazide Tablets, unless your healthcare provider considers it life-saving for you. Your healthcare provider should closely observe infants with a history of in utero exposure to Quinapril and Hydrochlorothiazide Tablets for signs of hypotension, oliguria, and hyperkalemia. Since quinapril and hydrochlorothiazide are secreted in human milk, please exercise caution when taking Quinapril and Hydrochlorothiazide Tablets while nursing. You and your healthcare provider should decide whether to discontinue nursing or to stop taking Quinapril and Hydrochlorothiazide Tablets, considering the importance of the medication for your health. Side Effects You may experience a cough (1.0%). You might have a headache (0.7%). You could experience a headache (6.7%). Dizziness (4.8%) may occur. Coughing (3.2%) is a possible side effect. You may feel fatigued (2.9%). Myalgia (2.4%) could be a concern. A viral infection (1.9%) may develop. You might experience rhinitis (2.0%). Nausea and/or vomiting (1.8%) may happen. You could have abdominal pain (1.7%). Back pain (1.5%) is a possibility. Diarrhea (1.4%) may occur. You might develop an upper respiratory infection (1.3%). Insomnia (1.2%) could affect you. Somnolence (1.2%) may be experienced. Bronchitis (1.2%) is a potential side effect. Dyspepsia (1.2%) may occur. You might feel asthenia (1.1%). Pharyngitis (1.1%) could develop. Vasodilatation (1.0%) may happen. You might experience vertigo (1.0%). Chest pain (1.0%) is a possibility. Shock is a serious concern. Accidental injury may occur. Neoplasm is a potential risk. Cellulitis may develop. Ascites is a possibility. Generalized edema may occur. You could experience a hernia. An anaphylactoid reaction is a serious concern. Bradycardia may happen. Cor pulmonale is a potential risk. Vasculitis may develop. Deep vein thrombosis is a serious concern. Gastrointestinal carcinoma is a potential risk. Cholestatic jaundice may occur. Hepatitis is a serious concern. Esophagitis may develop. Vomiting is a possibility. Diarrhea may occur. You might experience cramping. Nausea could happen. Gastric irritation may occur. Constipation is a possibility. You might experience anorexia. Vertigo may occur. Lightheadedness is a possibility. Transient blurred vision may happen. Paresthesia could develop. Xanthopsia is a potential side effect. You might feel weakness. Restlessness may occur. Muscle spasms could happen. Aplastic anemia is a serious concern. Agranulocytosis is a potential risk. Leukopenia may develop. Thrombocytopenia is a serious concern. Hemolytic anemia is a potential risk. Renal failure is a serious concern. Renal dysfunction may occur. Interstitial nephritis is a potential risk. Hyperglycemia may develop. Glycosuria is a possibility. Hyperuricemia may occur. Necrotizing angiitis is a serious concern. Stevens-Johnson syndrome is a serious risk. Respiratory distress may occur. Purpura is a potential side effect. Urticaria may develop. A rash could occur. Photosensitivity is a possibility. Acute myopia may happen. Acute angle closure glaucoma is a serious concern. Anemia may develop. Weight loss is a possibility. Myopathy could occur. Myositis is a potential risk. Arthritis may develop. Paralysis is a serious concern. Hemiplegia is a potential risk. You might experience a speech disorder. An abnormal gait may occur. Meningism is a potential risk. Amnesia may develop. Pneumonia is a serious concern. Asthma may occur. Respiratory infiltration is a potential risk. A lung disorder may develop. You might have abnormal kidney function. Albuminuria is a possibility. Pyuria may occur. Hematuria is a potential risk. Nephrosis may develop. Agranulocytosis is a serious concern. Thrombocytopenia is a serious risk. Arthralgia may occur. Angioedema is a serious concern. Intestinal angioedema may develop. Hypotension is a serious risk. Impaired renal function may occur. Hypotension is a serious concern. Acute renal failure is a serious risk. Fetal toxicity is a serious concern. Acute angle-closure glaucoma is a serious risk. Acute myopia may happen. Choroidal effusions are a potential risk. Warnings when pregnancy is detected, discontinue Quinapril and Hydrochlorothiazide Tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus angioedema of the face, extremities, lips, tongue, glottis, and larynx has been reported in patients treated with ACE inhibitors if laryngeal stridor or angioedema of the face, tongue, or glottis occurs, treatment with Quinapril and Hydrochlorothiazide Tablets should be discontinued immediately patients taking concomitant mTOR inhibitor therapy or a neprilysin inhibitor may be at increased risk for angioedema intestinal angioedema has been reported in patients treated with ACE inhibitors patients with a history of angioedema unrelated to ACE inhibitor therapy may be at increased risk of angioedema while receiving an ACE inhibitor two patients undergoing desensitizing treatment with Hymenoptera venom while receiving ACE inhibitors sustained life-threatening anaphylactoid reactions anaphylactoid reactions have been reported in patients dialyzed with high-flux membranes and treated concomitantly with an ACE inhibitor patients receiving ACE inhibitors who develop jaundice or marked elevations of hepatic enzymes should discontinue the ACE inhibitor and receive appropriate medical follow-up quinapril and hydrochlorothiazide tablets can cause symptomatic hypotension volume and/or salt depletion should be corrected before initiating therapy with Quinapril and Hydrochlorothiazide Tablets quinapril and hydrochlorothiazide tablets should be used cautiously in patients receiving concomitant therapy with other antihypertensives in patients at risk of excessive hypotension, therapy with Quinapril and Hydrochlorothiazide Tablets should be started under close medical supervision if excessive hypotension occurs, the patient should be placed in a supine position and treated with intravenous infusion of normal saline quinapril and hydrochlorothiazide tablets should be used with caution in patients with severe renal disease when the renin-angiotensin-aldosterone system is inhibited by quinapril, changes in renal function may be anticipated in susceptible individuals renal function should be monitored during the first few weeks of therapy dosage reduction of Quinapril and Hydrochlorothiazide Tablets may be required in patients with pre-existing renal impairment periodic monitoring of white blood cell counts in patients with collagen vascular disease and/or renal disease should be considered use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death in the unusual case that there is no appropriate alternative to therapy with drugs affecting the renin-angiotensin system for a particular patient, apprise the mother of the potential risk to the fetus patients and physicians should be aware that oligohydramnios may not appear until after the fetus has sustained irreversible injury quinapril and hydrochlorothiazide tablets should be used with caution in patients with impaired hepatic function or progressive liver disease thiazide diuretics have been reported to cause exacerbation or activation of systemic lupus erythematosus hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute angle closure glaucoma and elevated intraocular pressure tell patients receiving Quinapril and Hydrochlorothiazide Tablets to immediately report any signs or symptoms suggesting angioedema tell female patients of childbearing age about the consequences of exposure to Quinapril and Hydrochlorothiazide Tablets during pregnancy tell patients receiving Quinapril and Hydrochlorothiazide Tablets that lightheadedness can occur, especially during the first days of therapy tell patients that inadequate fluid intake, excessive perspiration, diarrhea, or vomiting can lead to an excessive fall in blood pressure tell patients receiving Quinapril and Hydrochlorothiazide Tablets not to use potassium supplements or salt substitutes containing potassium without consulting the prescribing physician tell patients to promptly report any indication of infection which could be a sign of neutropenia instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening therapy with Quinapril and Hydrochlorothiazide Tablets should be interrupted for a few days before carrying out tests of parathyroid function monitor serum potassium in patients coadministered Quinapril and Hydrochlorothiazide Tablets with other drugs that raise serum potassium levels quinapril and hydrochlorothiazide tablets and lithium should be coadministered with caution, and frequent monitoring of serum lithium levels is recommended dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function do not co-administer aliskiren with Quinapril and Hydrochlorothiazide Tablets in patients with diabetes caution should be exercised when Quinapril and Hydrochlorothiazide Tablets are administered to a nursing woman a decision should be made whether to discontinue nursing or to discontinue Quinapril and Hydrochlorothiazide Tablets, taking into account the importance of the drug to the mother in patients with oliguria or hypotension, direct attention toward support of blood pressure and renal perfusion Pregnancy & Lactation No pregnancy & lactation warnings reported. Side Effects cough (1.0%) headache (0.7%) headache (6.7%) dizziness (4.8%) coughing (3.2%) fatigue (2.9%) myalgia (2.4%) viral infection (1.9%) rhinitis (2.0%) nausea and/or vomiting (1.8%) abdominal pain (1.7%) back pain (1.5%) diarrhea (1.4%) upper respiratory infection (1.3%) insomnia (1.2%) somnolence (1.2%) bronchitis (1.2%) dyspepsia (1.2%) asthenia (1.1%) pharyngitis (1.1%) vasodilatation (1.0%) vertigo (1.0%) chest pain (1.0%) shock accidental injury neoplasm cellulitis ascites generalized edema hernia anaphylactoid reaction bradycardia cor pulmonale vasculitis deep vein thrombosis gastrointestinal carcinoma cholestatic jaundice hepatitis esophagitis vomiting diarrhea cramping nausea gastric irritation constipation anorexia vertigo lightheadedness transient blurred vision paresthesia xanthopsia weakness restlessness muscle spasm aplastic anemia agranulocytosis leukopenia thrombocytopenia hemolytic anemia renal failure renal dysfunction interstitial nephritis hyperglycemia glycosuria hyperuricemia necrotizing angiitis Stevens-Johnson syndrome respiratory distress purpura urticaria rash photosensitivity acute myopia acute angle closure glaucoma anemia weight loss myopathy myositis arthritis paralysis hemiplegia speech disorder abnormal gait meningism amnesia pneumonia asthma respiratory infiltration lung disorder kidney function abnormal albuminuria pyuria hematuria nephrosis agranulocytosis thrombocytopenia arthralgia angioedema intestinal angioedema hypotension impaired renal function hypotension acute renal failure fetal toxicity acute angle-closure glaucoma acute myopia choroidal effusions
Quinapril Hydrochloride/Hydrochlorothiazide Rx tablet, film coated Aurobindo Pharma Limited	Popularity – score 0 out of 100 (least-viewed drug)	24 warnings	2 pregnancy and lactation warnings	84 side effects	Trend: was flat over 11 months.
Quinapril Hydrochloride/Hydrochlorothiazide® · First marketed 2007 · Label last revised April 28, 2024View full label details → Warnings If you find out you are pregnant, please stop taking quinapril and hydrochlorothiazide as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. Angioedema affecting the face, extremities, lips, tongue, glottis, and larynx has been reported in patients treated with ACE inhibitors. If you experience laryngeal stridor or angioedema of the face, tongue, or glottis, discontinue treatment with quinapril and hydrochlorothiazide immediately. If you are taking mTOR inhibitors or neprilysin inhibitors, you may have an increased risk of angioedema. Intestinal angioedema has been reported in patients treated with ACE inhibitors. If you have a history of angioedema unrelated to ACE inhibitor therapy, you may be at a higher risk of angioedema while taking an ACE inhibitor. If you develop jaundice or significant elevations in liver enzymes while on ACE inhibitors, please stop the medication and seek appropriate medical follow-up. Quinapril and hydrochlorothiazide can cause symptomatic hypotension. Make sure to correct any volume and/or salt depletion before starting therapy with quinapril and hydrochlorothiazide. Use quinapril and hydrochlorothiazide cautiously if you are also taking other antihypertensive medications. If you are at risk for excessive hypotension, start therapy with quinapril and hydrochlorothiazide under close medical supervision. Use quinapril and hydrochlorothiazide with caution if you have severe renal disease. When quinapril inhibits the renin-angiotensin-aldosterone system, expect potential changes in renal function if you are susceptible. Your evaluation as a hypertensive patient should include an assessment of your renal function. If you are receiving quinapril and hydrochlorothiazide, please report any signs or symptoms of angioedema immediately. If you are a female of childbearing age, be aware of the risks associated with exposure to quinapril and hydrochlorothiazide during pregnancy. You may experience lightheadedness, especially during the first few days of therapy with quinapril and hydrochlorothiazide. Inadequate fluid intake, excessive sweating, diarrhea, or vomiting can lead to a significant drop in blood pressure, so please be mindful. Do not use potassium supplements or salt substitutes containing potassium without consulting your prescribing physician while on quinapril and hydrochlorothiazide. Promptly report any signs of infection, as this could indicate neutropenia. If you are taking hydrochlorothiazide, protect your skin from the sun and have regular skin cancer screenings. Exercise caution if quinapril and hydrochlorothiazide is administered to a nursing woman. A decision should be made about whether to continue nursing or to stop taking quinapril and hydrochlorothiazide, considering the importance of the medication to the mother. Pregnancy & Lactation You should be cautious when taking quinapril and hydrochlorothiazide if you are nursing. You and your healthcare provider should decide whether to continue nursing or to stop taking quinapril and hydrochlorothiazide, considering how important the medication is for you. Side Effects You may experience a cough (1%). You might have a headache (0.7%). You could experience a headache (6.7%). Dizziness (4.8%) may occur. Coughing (3.2%) is a possible side effect. You may feel fatigued (2.9%). Myalgia (2.4%) could be a concern. A viral infection (1.9%) may develop. You might experience rhinitis (2%). Nausea and/or vomiting (1.8%) may happen. You could have abdominal pain (1.7%). Back pain (1.5%) is a possibility. Diarrhea (1.4%) may occur. You might experience an upper respiratory infection (1.3%). Insomnia (1.2%) could affect you. Somnolence (1.2%) may be experienced. Bronchitis (1.2%) is a potential side effect. Dyspepsia (1.2%) may occur. You might feel asthenia (1.1%). Pharyngitis (1.1%) could be a concern. Vasodilatation (1%) may happen. You might experience vertigo (1%). Chest pain (1%) is a possibility. Shock is a serious condition to be aware of. Accidental injury is a risk. Neoplasm is a potential concern. Cellulitis may occur. Ascites is a possibility. Generalized edema may develop. A hernia is a potential risk. An anaphylactoid reaction is a serious concern. Bradycardia may occur. Cor pulmonale is a potential risk. Vasculitis may develop. Deep vein thrombosis is a serious condition to monitor. Gastrointestinal carcinoma is a potential concern. Cholestatic jaundice may occur. Hepatitis is a serious condition to be aware of. Esophagitis may develop. Vomiting is a possible side effect. Diarrhea may occur. You might experience cramping. Nausea is a potential side effect. Gastric irritation may happen. Constipation is a possibility. Anorexia may occur. You might experience vertigo. Lightheadedness is a potential side effect. Transient blurred vision may occur. You might feel weakness. Restlessness is a possibility. Muscle spasm may occur. Aplasia anemia is a serious condition to monitor. Agranulocytosis is a serious concern. Leukopenia may develop. Thrombocytopenia is a potential risk. Hemolytic anemia is a serious condition to be aware of. Renal failure is a serious concern. Renal dysfunction may occur. Interstitial nephritis is a potential risk. Hyperglycemia may develop. Glycosuria is a possibility. Hyperuricemia may occur. Necrotizing angiitis is a serious condition to monitor. Stevens-Johnson syndrome is a serious concern. Respiratory distress may occur. Purpura is a potential risk. Urticaria may develop. A rash is a possible side effect. Photosensitivity may occur. You might feel weakness. Orthostatic hypotension is a potential concern. Pancreatitis is a serious condition to monitor. Jaundice (intrahepatic cholestatic) may occur. Sialadenitis is a potential risk. Acute myopia may develop. Acute angle closure glaucoma is a serious condition to be aware of. Hypotension may occur. Impaired renal function is a potential concern. Acute renal failure is a serious condition to monitor. Impotence may occur. Agranulocytosis is a serious concern. Thrombocytopenia is a potential risk. You might experience arthralgia. Warnings when pregnancy is detected, discontinue quinapril and hydrochlorothiazide as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus angioedema of the face, extremities, lips, tongue, glottis, and larynx has been reported in patients treated with ACE inhibitors if laryngeal stridor or angioedema of the face, tongue, or glottis occurs, treatment with quinapril and hydrochlorothiazide should be discontinued immediately patients taking concomitant mTOR inhibitor therapy or a neprilysin inhibitor may be at increased risk for angioedema intestinal angioedema has been reported in patients treated with ACE inhibitors patients with a history of angioedema unrelated to ACE inhibitor therapy may be at increased risk of angioedema while receiving an ACE inhibitor patients receiving ACE inhibitors who develop jaundice or marked elevations of hepatic enzymes should discontinue the ACE inhibitor and receive appropriate medical follow-up quinapril and hydrochlorothiazide can cause symptomatic hypotension volume and/or salt depletion should be corrected before initiating therapy with quinapril and hydrochlorothiazide quinapril and hydrochlorothiazide should be used cautiously in patients receiving concomitant therapy with other antihypertensives in patients at risk of excessive hypotension, therapy with quinapril and hydrochlorothiazide should be started under close medical supervision quinapril and hydrochlorothiazide should be used with caution in patients with severe renal disease when the renin-angiotensin-aldosterone system is inhibited by quinapril, changes in renal function may be anticipated in susceptible individuals evaluation of the hypertensive patients should also include assessment of the renal function tell patients receiving quinapril and hydrochlorothiazide to immediately report any signs or symptoms suggesting angioedema tell female patients of childbearing age about the consequences of exposure to quinapril and hydrochlorothiazide during pregnancy tell patients receiving quinapril and hydrochlorothiazide that lightheadedness can occur, especially during the first days of therapy tell patients that inadequate fluid intake, excessive perspiration, diarrhea, or vomiting can lead to an excessive fall in blood pressure tell patients receiving quinapril and hydrochlorothiazide not to use potassium supplements or salt substitutes containing potassium without consulting the prescribing physician tell patients to promptly report any indication of infection which could be a sign of neutropenia instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening caution should be exercised when quinapril and hydrochlorothiazide is administered to a nursing woman a decision should be made whether to discontinue nursing or to discontinue quinapril and hydrochlorothiazide, taking into account the importance of the drug to the mother Pregnancy & Lactation caution should be exercised when quinapril and hydrochlorothiazide is administered to a nursing woman a decision should be made whether to discontinue nursing or to discontinue quinapril and hydrochlorothiazide, taking into account the importance of the drug to the mother Side Effects cough (1%) headache (0.7%) headache (6.7%) dizziness (4.8%) coughing (3.2%) fatigue (2.9%) myalgia (2.4%) viral infection (1.9%) rhinitis (2%) nausea and/or vomiting (1.8%) abdominal pain (1.7%) back pain (1.5%) diarrhea (1.4%) upper respiratory infection (1.3%) insomnia (1.2%) somnolence (1.2%) bronchitis (1.2%) dyspepsia (1.2%) asthenia (1.1%) pharyngitis (1.1%) vasodilatation (1%) vertigo (1%) chest pain (1%) shock accidental injury neoplasm cellulitis ascites generalized edema hernia anaphylactoid reaction bradycardia cor pulmonale vasculitis deep vein thrombosis gastrointestinal carcinoma cholestatic jaundice hepatitis esophagitis vomiting diarrhea cramping nausea gastric irritation constipation anorexia vertigo lightheadedness transient blurred vision weakness restlessness muscle spasm aplasia anemia agranulocytosis leukopenia thrombocytopenia hemolytic anemia renal failure renal dysfunction interstitial nephritis hyperglycemia glycosuria hyperuricemia necrotizing angiitis stevens-johnson syndrome respiratory distress purpura urticaria rash photosensitivity weakness orthostatic hypotension pancreatitis jaundice (intrahepatic cholestatic) sialadenitis acute myopia acute angle closure glaucoma hypotension impaired renal function acute renal failure impotence agranulocytosis thrombocytopenia arthralgia
Spironolactone and Hydrochlorothiazide Rx tablet Mylan Pharmaceuticals Inc.	Popularity – score 0 out of 100 (least-viewed drug)	22 warnings	7 pregnancy and lactation warnings	81 side effects	Trend: fell 23% over the year; peaks in Feb, May, Jul, Aug.
Spironolactone and Hydrochlorothiazide® · First marketed 1979 · Label last revised April 15, 2023View full label details → Warnings You should not normally take potassium supplements while on spironolactone and hydrochlorothiazide therapy. Excessive potassium intake may lead to hyperkalemia if you are receiving spironolactone and hydrochlorothiazide. Do not take spironolactone and hydrochlorothiazide at the same time as other potassium-sparing diuretics. Be extremely cautious if you are taking spironolactone and hydrochlorothiazide tablets along with ACE inhibitors or indomethacin. Use spironolactone and hydrochlorothiazide carefully if you have impaired hepatic function. Thiazides should be used with caution if you have severe renal disease. Thiazides may cause azotemia if you have renal disease. Cumulative effects of the drug may occur if you have impaired renal function. Sensitivity reactions to thiazides can happen whether or not you have a history of allergy or bronchial asthma. Gynecomastia may develop with the use of spironolactone. Some patients have reported experiencing somnolence and dizziness. Exercise caution when driving or operating machinery until you know how the initial treatment affects you. If you are taking spironolactone and hydrochlorothiazide, avoid potassium supplements and foods high in potassium, including salt substitutes. If you are taking hydrochlorothiazide, protect your skin from the sun and have regular skin cancer screenings. Your healthcare provider should periodically check your serum electrolytes to detect any possible electrolyte imbalances, especially if you are elderly or have significant renal or hepatic impairments. Lithium should generally not be taken with diuretics. Taking an NSAID can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing, and thiazide diuretics. If you are using spironolactone and hydrochlorothiazide tablets along with NSAIDs, your healthcare provider should closely monitor you to ensure the diuretic is effective. If you are pregnant, the use of spironolactone and hydrochlorothiazide requires careful consideration of the benefits versus potential risks to the fetus. It is not recommended to use spironolactone and hydrochlorothiazide while breastfeeding. If you must use spironolactone and hydrochlorothiazide while breastfeeding, keep the doses as low as possible. Safety and effectiveness in children have not been established. Pregnancy & Lactation Canrenone, a major active metabolite of spironolactone, can appear in human breast milk. Since spironolactone has been found to cause tumors in rats, you should consider whether to continue the medication, keeping in mind its importance to you. If you decide that the drug is essential, you may need to explore alternative methods of feeding your infant. It is not recommended to use spironolactone and hydrochlorothiazide while breastfeeding. If you do take these medications during this time, please keep the doses as low as possible. If you are pregnant, the use of spironolactone and hydrochlorothiazide requires careful consideration of the expected benefits versus potential risks to your fetus. Potential risks include fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Due to its antiandrogenic activity and the role of testosterone in male development, spironolactone may potentially affect sex differentiation in male embryos. Spironolactone has known endocrine effects in animals, including progestational and antiandrogenic effects. These antiandrogenic effects can lead to estrogen-like side effects in humans, such as gynecomastia. Currently, there are no adequate and well-controlled studies involving spironolactone and hydrochlorothiazide in pregnant women. Side Effects You may experience weakness. Hypotension, including orthostatic hypotension, may occur and can be worsened by alcohol, barbiturates, narcotics, or antihypertensive drugs. There is a risk of pancreatitis. You might develop jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea can occur. You may experience vomiting. Sialoadenitis is a possible side effect. Cramping may happen. You could experience constipation. Gastric irritation is a potential issue. Nausea may occur. You might experience anorexia. Acute myopia can develop. There is a risk of acute angle-closure glaucoma. Aplastic anemia is a possible side effect. You may experience agranulocytosis. Leukopenia can occur. Hemolytic anemia is a potential risk. Thrombocytopenia may happen. Anaphylactic reactions are possible. You might experience necrotizing angitis, which includes vasculitis and cutaneous vasculitis. Respiratory distress, including pneumonitis and pulmonary edema, may occur. Photosensitivity can happen. You may experience fever. Urticaria is a possible side effect. A rash may develop. Purpura can occur. Electrolyte imbalance is a potential risk. You might experience hyperglycemia. Glycosuria can occur. Hyperuricemia is a possible side effect. Muscle spasms may happen. You could experience vertigo. Paresthesias may occur. Dizziness can happen. You might experience headaches. Restlessness is a potential side effect. There is a risk of renal failure. Renal dysfunction may occur. Interstitial nephritis is a possible risk. Erythema multiforme can develop. You may experience pruritus. Transient blurred vision is a potential side effect. Xanthopsia may occur. Gastric bleeding is a possible risk. Ulceration can happen. Gastritis may occur. Diarrhea and cramping can happen. Nausea may occur. You might experience vomiting. Gynecomastia is a potential side effect. You may have difficulty achieving or maintaining an erection. Irregular menses or amenorrhea can occur. Postmenopausal bleeding is a possible risk. You might experience breast pain. Leukopenia, including agranulocytosis, can occur. Thrombocytopenia may happen. You may experience fever. Urticaria is a possible side effect. Maculopapular or erythematous cutaneous eruptions may occur. Anaphylactic reactions are possible. Vasculitis can happen. You might experience hyperkalemia. Electrolyte disturbances may occur. Leg cramps can happen. You may feel lethargic. Mental confusion is a potential side effect. Ataxia may occur. Dizziness can happen. You might experience headaches. Drowsiness is a possible side effect. Renal dysfunction, including renal failure, may occur. Stevens-Johnson Syndrome (SJS) is a potential risk. Toxic epidermal necrolysis (TEN) may occur. Drug rash with eosinophilia and systemic symptoms (DRESS) is a possible side effect. Alopecia may happen. You might experience pruritus. There is an increased risk of non-melanoma skin cancer. Acute angle-closure glaucoma and elevated intraocular pressure may occur, with or without a noticeable acute myopic shift and/or choroidal effusions. Somnolence is a possible side effect. Dizziness can happen. Warnings potassium supplementation should not ordinarily be given in association with spironolactone and hydrochlorothiazide therapy excessive potassium intake may cause hyperkalemia in patients receiving spironolactone and hydrochlorothiazide spironolactone and hydrochlorothiazide should not be administered concurrently with other potassium-sparing diuretics extreme caution should be exercised when spironolactone and hydrochlorothiazide tablets are given concomitantly with ACE inhibitors or indomethacin spironolactone and hydrochlorothiazide should be used with caution in patients with impaired hepatic function thiazides should be used with caution in severe renal disease thiazides may precipitate azotemia in patients with renal disease cumulative effects of the drug may develop in patients with impaired renal function sensitivity reactions to thiazides may occur in patients with or without a history of allergy or bronchial asthma gynecomastia may develop in association with the use of spironolactone somnolence and dizziness have been reported to occur in some patients caution is advised when driving or operating machinery until the response to initial treatment has been determined patients who receive spironolactone and hydrochlorothiazide should be advised to avoid potassium supplements and foods containing high levels of potassium including salt substitutes instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening periodic determination of serum electrolytes to detect possible electrolyte imbalance should be done at appropriate intervals, particularly in the elderly and those with significant renal or hepatic impairments lithium generally should not be given with diuretics the administration of an NSAID can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing, and thiazide diuretics when spironolactone and hydrochlorothiazide tablets and NSAIDs are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained the use of spironolactone and hydrochlorothiazide in pregnant women requires that the anticipated benefit be weighed against the possible hazards to the fetus the use of spironolactone and hydrochlorothiazide during breast feeding is not recommended if spironolactone and hydrochlorothiazide tablets are used during breast feeding, doses should be kept as low as possible safety and effectiveness in pediatric patients have not been established Pregnancy & Lactation Canrenone, a major (and active) metabolite of spironolactone, appears in human breast milk. Because spironolactone has been found to be tumorigenic in rats, a decision should be made whether to discontinue the drug, taking into account the importance of the drug to the mother. If use of the drug is deemed essential, an alternative method of infant feeding should be instituted. The use of spironolactone and hydrochlorothiazide during breast feeding is not recommended. If spironolactone and hydrochlorothiazide tablets are used during breast feeding, doses should be kept as low as possible. The use of spironolactone and hydrochlorothiazide in pregnant women requires that the anticipated benefit be weighed against possible hazards to the fetus. The hazards include fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults. Because of its antiandrogenic activity and the requirement of testosterone for male morphogenesis, spironolactone may have the potential for adversely affecting sex differentiation of the male during embryogenesis. Spironolactone has known endocrine effects in animals including progestational and antiandrogenic effects. The antiandrogenic effects can result in apparent estrogenic side effects in humans, such as gynecomastia. There are no adequate and well-controlled studies with spironolactone and hydrochlorothiazide in pregnant women. Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics, or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialoadenitis cramping constipation gastric irritation nausea anorexia acute myopia acute angle-closure glaucoma aplasticanemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesias dizziness headache restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme pruritus transient blurred vision xanthopsia gastric bleeding ulceration gastritis diarrhea and cramping nausea vomiting gynecomastia inability to achieve or maintain erection irregular menses or amenorrhea postmenopausal bleeding breast pain leukopenia (including agranulocytosis) thrombocytopenia fever urticaria maculopapular or erythematous cutaneous eruptions anaphylactic reactions vasculitis hyperkalemia electrolyte disturbances leg cramps lethargy mental confusion ataxia dizziness headache drowsiness renal dysfunction (including renal failure) Stevens-Johnson Syndrome (SJS) toxic epidermal necrolysis (TEN) drug rash with eosinophilia and systemic symptoms (DRESS) alopecia pruritus increased risk of non-melanoma skin cancer acute angle-closure glaucoma and elevated intraocular pressure with or without a noticeable acute myopic shift and/or choroidal effusions somnolence dizziness
Spironolactone and Hydrochlorothiazide Rx tablet, film coated Prasco Laboratories	Popularity – score 0 out of 100 (least-viewed drug)	28 warnings	7 pregnancy and lactation warnings	87 side effects	Trend: fell 23% over the year; peaks in Feb, May, Jul, Aug.
Spironolactone and Hydrochlorothiazide® · First marketed 2021 · Label last revised January 22, 2025View full label details → Warnings You should not normally take potassium supplements while on spironolactone and hydrochlorothiazide tablet therapy. Excessive potassium intake may lead to hyperkalemia if you are receiving spironolactone and hydrochlorothiazide tablets. Do not take spironolactone and hydrochlorothiazide tablets at the same time as other potassium-sparing diuretics. Be extremely cautious if you are taking spironolactone and hydrochlorothiazide tablets along with ACE inhibitors or indomethacin. Use spironolactone and hydrochlorothiazide tablets carefully if you have impaired hepatic function. Thiazides should be used with caution if you have severe renal disease. Thiazides may cause azotemia if you have renal disease. If you have impaired renal function, cumulative effects of the drug may develop. Sensitivity reactions to thiazides can occur whether or not you have a history of allergy or bronchial asthma. Gynecomastia may develop while using spironolactone. Exercise caution when driving or operating machinery until you know how you respond to the initial treatment. You should avoid potassium supplements and foods high in potassium, including salt substitutes. If you are taking hydrochlorothiazide, protect your skin from the sun and have regular skin cancer screenings. Your healthcare provider should periodically check your serum electrolytes to detect possible imbalances, especially if you are elderly or have significant renal or hepatic impairments. Taking spironolactone and hydrochlorothiazide tablets with drugs that raise serum potassium may lead to severe hyperkalemia. Be aware that alcohol, barbiturates, or narcotics may increase the risk of orthostatic hypotension. You may need a dosage adjustment of your antidiabetic medication. Corticosteroids or ACTH may lead to intensified electrolyte depletion, particularly hypokalemia. Your healthcare provider should exercise caution when managing you under regional or general anesthesia while you are treated with spironolactone and hydrochlorothiazide tablets. You may experience increased responsiveness to muscle relaxants. Lithium should generally not be taken with diuretics due to the high risk of lithium toxicity. Taking an NSAID can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing, and thiazide diuretics. Acetylsalicylic acid may reduce the effectiveness of spironolactone. Your healthcare provider should monitor your serum digoxin levels and adjust your dose accordingly due to the increased risk of digoxin toxicity. Hyperkalemic metabolic acidosis has been reported in patients taking spironolactone with cholestyramine. It is not recommended to use spironolactone concurrently in prostate cancer patients treated with abiraterone. If you are pregnant, the use of spironolactone and hydrochlorothiazide tablets requires weighing the anticipated benefits against possible risks to the fetus. It is not recommended to use spironolactone and hydrochlorothiazide tablets while breastfeeding. Pregnancy & Lactation Spironolactone may potentially affect sex differentiation in males during embryonic development. If you are pregnant, your healthcare provider will need to weigh the expected benefits of using spironolactone and hydrochlorothiazide tablets against any possible risks to your fetus. Possible risks include fetal or neonatal jaundice, thrombocytopenia, and other adverse reactions that have been observed in adults. Currently, there are no adequate and well-controlled studies on the use of spironolactone and hydrochlorothiazide tablets in pregnant women. If your healthcare provider determines that using this medication is essential, consider discussing alternative infant feeding methods. It is not recommended to use spironolactone and hydrochlorothiazide tablets while breastfeeding. If you must use spironolactone and hydrochlorothiazide tablets while breastfeeding, keep the doses as low as possible. Side Effects You may experience weakness. Hypotension, including orthostatic hypotension, may occur and can be worsened by alcohol, barbiturates, narcotics, or antihypertensive drugs. Pancreatitis is a possible side effect. You might notice jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea can happen. You may experience vomiting. Sialoadenitis is a potential side effect. Cramping may occur. You might experience constipation. Gastric irritation can happen. Nausea is a possible side effect. You may experience anorexia. Acute myopia can occur. Be aware of the risk of acute angle-closure glaucoma. Aplastic anemia is a potential side effect. Agranulocytosis may occur. You might experience leukopenia. Hemolytic anemia is a possible side effect. Thrombocytopenia can happen. Anaphylactic reactions are a serious possibility. Necrotizing angitis, including vasculitis and cutaneous vasculitis, may occur. Respiratory distress, including pneumonitis and pulmonary edema, can happen. You may experience photosensitivity. Fever is a possible side effect. Urticaria may occur. You might notice a rash. Purpura can happen. Electrolyte imbalance is a potential side effect. Hyperglycemia may occur. Glycosuria is a possible side effect. Hyperuricemia can happen. Muscle spasms may occur. You might experience vertigo. Paresthesias can happen. Dizziness is a possible side effect. You may experience headaches. Restlessness can occur. Renal failure is a serious potential side effect. Renal dysfunction may happen. Interstitial nephritis is a possible side effect. Erythema multiforme can occur. You might experience pruritus. Transient blurred vision may happen. Xanthopsia is a possible side effect. Gastric bleeding can occur. Ulceration may happen. Gastritis is a potential side effect. Diarrhea and cramping can occur. Nausea may happen. You might experience vomiting. Gynecomastia is a possible side effect. You may have difficulty achieving or maintaining an erection. Irregular menses or amenorrhea can occur. Postmenopausal bleeding is a potential side effect. You might experience breast pain. Leukopenia, including agranulocytosis, may occur. Thrombocytopenia can happen. Fever is a possible side effect. Urticaria may occur. You might notice maculopapular or erythematous cutaneous eruptions. Anaphylactic reactions are a serious possibility. Vasculitis may occur. Hyperkalemia is a potential side effect. Electrolyte disturbances can happen. Leg cramps may occur. You might experience lethargy. Mental confusion is a possible side effect. Ataxia can happen. Dizziness is a possible side effect. You may experience drowsiness. Renal dysfunction, including renal failure, is a serious potential side effect. Stevens-Johnson Syndrome (SJS) may occur. Toxic epidermal necrolysis (TEN) is a serious possibility. Drug rash with eosinophilia and systemic symptoms (DRESS) may occur. Alopecia is a potential side effect. You might experience pruritus. Acute angle-closure glaucoma is a risk. Elevated intraocular pressure may occur. Be aware of the acute onset of decreased visual acuity or ocular pain. Hyperkalemia is a potential side effect. Hypokalemia may occur. Hyponatremia is a possible side effect. Hypomagnesemia can happen. Gynecomastia is a potential side effect. Somnolence may occur. Dizziness is a possible side effect. Warnings potassium supplementation should not ordinarily be given in association with spironolactone and hydrochlorothiazide tablet therapy excessive potassium intake may cause hyperkalemia in patients receiving spironolactone and hydrochlorothiazide tablets spironolactone and hydrochlorothiazide tablets should not be administered concurrently with other potassium-sparing diuretics extreme caution should be exercised when spironolactone and hydrochlorothiazide tablets are given concomitantly with ACE inhibitors or indomethacin spironolactone and hydrochlorothiazide tablets should be used with caution in patients with impaired hepatic function thiazides should be used with caution in severe renal disease thiazides may precipitate azotemia in patients with renal disease cumulative effects of the drug may develop in patients with impaired renal function sensitivity reactions to thiazides may occur in patients with or without a history of allergy or bronchial asthma gynecomastia may develop in association with the use of spironolactone caution is advised when driving or operating machinery until the response to initial treatment has been determined patients should be advised to avoid potassium supplements and foods containing high levels of potassium including salt substitutes patients taking hydrochlorothiazide should protect skin from the sun and undergo regular skin cancer screening periodic determination of serum electrolytes to detect possible electrolyte imbalance should be done at appropriate intervals, particularly in the elderly and those with significant renal or hepatic impairments concomitant administration of spironolactone and hydrochlorothiazide tablets with drugs that raise serum potassium may lead to severe hyperkalemia potentiation of orthostatic hypotension may occur with alcohol, barbiturates, or narcotics dosage adjustment of the antidiabetic drug may be required intensified electrolyte depletion, particularly hypokalemia, may occur with corticosteroids or ACTH caution should be exercised in the management of patients subjected to regional or general anesthesia while treated with spironolactone and hydrochlorothiazide tablets possible increased responsiveness to muscle relaxants may result lithium generally should not be given with diuretics due to the high risk of lithium toxicity administration of an NSAID can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing, and thiazide diuretics acetylsalicylic acid may reduce the efficacy of spironolactone monitor serum digoxin levels and adjust dose accordingly due to increased risk of digoxin toxicity hyperkalemic metabolic acidosis has been reported in patients given spironolactone concurrently with cholestyramine concomitant use of spironolactone is not recommended in abiraterone-treated prostate cancer patients the use of spironolactone and hydrochlorothiazide tablets in pregnant women requires that the anticipated benefit be weighed against the possible hazards to the fetus the use of spironolactone and hydrochlorothiazide tablets during breast feeding is not recommended Pregnancy & Lactation spironolactone may have the potential for adversely affecting sex differentiation of the male during embryogenesis the use of spironolactone and hydrochlorothiazide tablets in pregnant women requires that the anticipated benefit be weighed against the possible hazards to the fetus the hazards include fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults there are no adequate and well-controlled studies with spironolactone and hydrochlorothiazide tablets in pregnant women if use of the drug is deemed essential, an alternative method of infant feeding should be instituted the use of spironolactone and hydrochlorothiazide tablets during breast feeding is not recommended if spironolactone and hydrochlorothiazide tablets are used during breast feeding, doses should be kept as low as possible Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics, or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialoadenitis cramping constipation gastric irritation nausea anorexia acute myopia acute angle-closure glaucoma aplasticanemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesias dizziness headache restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme pruritus transient blurred vision xanthopsia gastric bleeding ulceration gastritis diarrhea and cramping nausea vomiting gynecomastia inability to achieve or maintain erection irregular menses or amenorrhea postmenopausal bleeding breast pain leukopenia (including agranulocytosis) thrombocytopenia fever urticaria maculopapular or erythematous cutaneous eruptions anaphylactic reactions vasculitis hyperkalemia electrolyte disturbances leg cramps lethargy mental confusion ataxia dizziness headache drowsiness renal dysfunction (including renal failure) Stevens-Johnson Syndrome (SJS) toxic epidermal necrolysis (TEN) drug rash with eosinophilia and systemic symptoms (DRESS) alopecia pruritus acute angle-closure glaucoma elevated intraocular pressure acute onset of decreased visual acuity or ocular pain hyperkalemia hypokalemia hyponatremia hypomagnesemia gynecomastia somnolence dizziness
Spironolactone and Hydrochlorothiazide Rx tablet Sun Pharmaceutical Industries, Inc.	Popularity – score 0 out of 100 (least-viewed drug)	33 warnings	6 pregnancy and lactation warnings	78 side effects	Trend: fell 23% over the year; peaks in Feb, May, Jul, Aug.
Spironolactone and Hydrochlorothiazide® · First marketed 1987 · Label last revised December 9, 2025View full label details → Warnings You should not normally take potassium supplements while using spironolactone and hydrochlorothiazide tablets. Excessive potassium intake may lead to hyperkalemia if you are receiving spironolactone and hydrochlorothiazide tablets. Do not take spironolactone and hydrochlorothiazide tablets at the same time as other potassium-sparing diuretics. Be very cautious if you are taking spironolactone and hydrochlorothiazide tablets along with ACE inhibitors or indomethacin. Use spironolactone and hydrochlorothiazide tablets carefully if you have impaired liver function. Thiazides should be used with caution if you have severe kidney disease. Thiazides may cause azotemia if you have kidney disease. If you have impaired kidney function, the cumulative effects of the drug may develop. You may experience sensitivity reactions to thiazides, even if you do not have a history of allergies or asthma. Gynecomastia may occur with the use of spironolactone. Some patients have reported feeling drowsy or dizzy. Be cautious when driving or operating machinery until you know how you respond to the initial treatment. You should avoid potassium supplements and foods high in potassium, including salt substitutes. If you are taking hydrochlorothiazide, protect your skin from the sun and have regular skin cancer screenings. Your healthcare provider should periodically check your serum electrolytes to detect any possible imbalances, especially if you are elderly or have significant kidney or liver issues. Taking spironolactone and hydrochlorothiazide tablets with ACE inhibitors, angiotensin II receptor antagonists, aldosterone blockers, potassium supplements, heparin, low molecular weight heparin, and other drugs that can cause hyperkalemia may lead to severe hyperkalemia. Be aware that alcohol, barbiturates, or narcotics may increase the risk of orthostatic hypotension. You may need to adjust the dosage of your antidiabetic medication. Corticosteroids or ACTH may lead to intensified electrolyte depletion, particularly hypokalemia. Your healthcare provider should exercise caution when managing patients undergoing regional or general anesthesia while being treated with spironolactone and hydrochlorothiazide tablets. You may experience increased responsiveness to skeletal muscle relaxants. Lithium should generally not be taken with diuretics due to the high risk of lithium toxicity. Taking an NSAID can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing, and thiazide diuretics. Your healthcare provider should closely observe you to determine if the desired effect of the diuretic is achieved when NSAIDs are used together. Spironolactone has been shown to increase the half-life of digoxin, which may raise serum digoxin levels and lead to digitalis toxicity. Your healthcare provider should monitor your serum digoxin levels and adjust your dose as needed. Hyperkalemic metabolic acidosis has been reported in patients taking spironolactone with cholestyramine. It is not recommended to use spironolactone in patients treated with abiraterone for prostate cancer. Avoid using spironolactone and hydrochlorothiazide tablets together with mitotane. If you are pregnant, the use of spironolactone and hydrochlorothiazide requires careful consideration of the benefits versus potential risks to the fetus. It is not recommended to use spironolactone and hydrochlorothiazide tablets while breastfeeding. If you must use spironolactone and hydrochlorothiazide tablets while breastfeeding, keep the doses as low as possible. The safety and effectiveness of this medication in children have not been established. Pregnancy & Lactation Canrenone can be found in human breast milk, so you should decide whether to continue the medication, considering how important it is for your health. If you find that using this medication is essential, you should consider an alternative method for feeding your infant. It's not recommended to use spironolactone and hydrochlorothiazide tablets while breastfeeding. If you must use spironolactone and hydrochlorothiazide tablets during breastfeeding, try to keep the doses as low as possible. Using diuretics routinely in a healthy woman is not appropriate and can pose unnecessary risks to both you and your baby. Diuretics do not prevent the development of toxemia during pregnancy, and there is no strong evidence that they are effective in treating it. Side Effects You may experience weakness. Hypotension, including orthostatic hypotension, may occur and can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. There is a risk of pancreatitis. You might develop jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea can occur. You may experience vomiting. Sialoadenitis is a possible side effect. Cramping may happen. You might experience constipation. Gastric irritation can occur. Nausea is a potential side effect. You may experience anorexia. Acute myopia may develop. There is a risk of acute angle-closure glaucoma. Aplastic anemia is a possible side effect. You may experience agranulocytosis. Leukopenia can occur. There is a risk of hemolytic anemia. Thrombocytopenia may develop. Anaphylactic reactions are a serious possibility. You might experience necrotizing angitis, which includes vasculitis and cutaneous vasculitis. Respiratory distress, including pneumonitis and pulmonary edema, may occur. Photosensitivity is a potential side effect. You may experience fever. Urticaria can occur. A rash may develop. Purpura is a possible side effect. Electrolyte imbalance may occur. You might experience hyperglycemia. Glycosuria can happen. There is a risk of hyperuricemia. Muscle spasms may occur. You might experience vertigo. Paresthesias can happen. Dizziness is a potential side effect. You may experience headaches. Restlessness can occur. There is a risk of renal failure. Renal dysfunction may develop. Interstitial nephritis is a possible side effect. Erythema multiforme may occur. You might experience pruritus. Transient blurred vision can happen. Xanthopsia is a potential side effect. Gastric bleeding may occur. Ulceration is a possible side effect. Gastritis can happen. Diarrhea and cramping may occur. You might experience nausea. Vomiting is a potential side effect. Gynecomastia may develop. You might have difficulty achieving or maintaining an erection. Irregular menses or amenorrhea can occur. Postmenopausal bleeding is a possible side effect. You may experience breast pain. Leukopenia, including agranulocytosis, can occur. Thrombocytopenia may develop. You might experience fever. Urticaria is a potential side effect. Maculopapular or erythematous cutaneous eruptions may occur. Anaphylactic reactions are a serious possibility. Vasculitis can happen. You may experience hyperkalemia. Electrolyte disturbances are a potential side effect. Leg cramps may occur. You might feel lethargic. Mental confusion can happen. Ataxia is a possible side effect. Dizziness may occur. You might experience headaches. Drowsiness is a potential side effect. Renal dysfunction, including renal failure, may develop. Stevens-Johnson Syndrome (SJS) is a serious risk. Toxic epidermal necrolysis (TEN) may occur. Drug rash with eosinophilia and systemic symptoms (DRESS) is a possible side effect. Alopecia may develop. You might experience pruritus. There is an increased risk of non-melanoma skin cancer. Warnings potassium supplementation should not ordinarily be given in association with spironolactone and hydrochlorothiazide tablets therapy excessive potassium intake may cause hyperkalemia in patients receiving spironolactone and hydrochlorothiazide tablets spironolactone and hydrochlorothiazide tablets should not be administered concurrently with other potassium-sparing diuretics extreme caution should be exercised when spironolactone and hydrochlorothiazide tablets are given concomitantly with ACE inhibitors or indomethacin spironolactone and hydrochlorothiazide tablets should be used with caution in patients with impaired hepatic function thiazides should be used with caution in severe renal disease thiazides may precipitate azotemia in patients with renal disease cumulative effects of the drug may develop in patients with impaired renal function sensitivity reactions to thiazides may occur in patients with or without a history of allergy or bronchial asthma gynecomastia may develop in association with the use of spironolactone somnolence and dizziness have been reported to occur in some patients caution is advised when driving or operating machinery until the response to initial treatment has been determined patients should be advised to avoid potassium supplements and foods containing high levels of potassium including salt substitutes patients taking hydrochlorothiazide should protect skin from the sun and undergo regular skin cancer screening periodic determination of serum electrolytes to detect possible electrolyte imbalance should be done at appropriate intervals, particularly in the elderly and those with significant renal or hepatic impairments concomitant administration of spironolactone and hydrochlorothiazide tablets with ACE inhibitors, angiotensin II receptor antagonists, aldosterone blockers, potassium supplements, heparin, low molecular weight heparin, and other drugs known to cause hyperkalemia may lead to severe hyperkalemia potentiation of orthostatic hypotension may occur with alcohol, barbiturates, or narcotics dosage adjustment of the antidiabetic drug may be required intensified electrolyte depletion, particularly hypokalemia, may occur with corticosteroids or ACTH caution should be exercised in the management of patients subjected to regional or general anesthesia while they are being treated with spironolactone and hydrochlorothiazide tablets possible increased responsiveness to skeletal muscle relaxants may result lithium generally should not be given with diuretics due to the high risk of lithium toxicity administration of an NSAID can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing, and thiazide diuretics patients should be observed closely to determine if the desired effect of the diuretic is obtained when NSAIDs are used concomitantly spironolactone has been shown to increase the half-life of digoxin, which may result in increased serum digoxin levels and subsequent digitalis toxicity monitor serum digoxin levels and adjust dose accordingly hyperkalemic metabolic acidosis has been reported in patients given spironolactone concurrently with cholestyramine concomitant use of spironolactone is not recommended in abiraterone-treated prostate cancer patients avoid concomitant use of spironolactone and hydrochlorothiazide tablets and mitotane the use of spironolactone and hydrochlorothiazide in pregnant women requires that the anticipated benefit be weighed against the possible hazards to the fetus the use of spironolactone and hydrochlorothiazide tablets during breast feeding is not recommended if spironolactone and hydrochlorothiazide tablets are used during breast feeding, doses should be kept as low as possible safety and effectiveness in pediatric patients have not been established Pregnancy & Lactation canrenone appears in human breast milk; a decision should be made whether to discontinue the drug, taking into account the importance of the drug to the mother if use of the drug is deemed essential, an alternative method of infant feeding should be instituted the use of spironolactone and hydrochlorothiazide tablets during breast feeding is not recommended if spironolactone and hydrochlorothiazide tablets are used during breast feeding, doses should be kept as low as possible the routine use of diuretics in an otherwise healthy woman is inappropriate and exposes mother and fetus to unnecessary hazard diuretics do not prevent development of toxemia of pregnancy, and there is no satisfactory evidence that they are useful in the treatment of developing toxemia Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics, or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialoadenitis cramping constipation gastric irritation nausea anorexia acute myopia acute angle-closure glaucoma aplastic anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesias dizziness headache restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme pruritus transient blurred vision xanthopsia gastric bleeding ulceration gastritis diarrhea and cramping nausea vomiting gynecomastia inability to achieve or maintain erection irregular menses or amenorrhea postmenopausal bleeding breast pain leukopenia (including agranulocytosis) thrombocytopenia fever urticaria maculopapular or erythematous cutaneous eruptions anaphylactic reactions vasculitis hyperkalemia electrolyte disturbances leg cramps lethargy mental confusion ataxia dizziness headache drowsiness renal dysfunction (including renal failure) Stevens-Johnson Syndrome (SJS) toxic epidermal necrolysis (TEN) drug rash with eosinophilia and systemic symptoms (DRESS) alopecia pruritus increased risk of non-melanoma skin cancer
Spironolactone and Hydrochlorothiazide Rx tablet Mylan Institutional Inc.	Popularity – score 0 out of 100 (least-viewed drug)	29 warnings	7 pregnancy and lactation warnings	81 side effects	Trend: fell 23% over the year; peaks in Feb, May, Jul, Aug.
Spironolactone and Hydrochlorothiazide® · First marketed 2017 · Label last revised July 22, 2025View full label details → Warnings You should not ordinarily take potassium supplements while on spironolactone and hydrochlorothiazide therapy. Excessive potassium intake may lead to hyperkalemia if you are receiving spironolactone and hydrochlorothiazide. Do not take spironolactone and hydrochlorothiazide at the same time as other potassium-sparing diuretics. Exercise extreme caution if you are taking spironolactone and hydrochlorothiazide along with ACE inhibitors or indomethacin. Use spironolactone and hydrochlorothiazide carefully if you have impaired hepatic function. Thiazides should be used cautiously in cases of severe renal disease. Thiazides may cause azotemia if you have renal disease. If you have impaired renal function, cumulative effects of the drug may develop. Sensitivity reactions to thiazides can occur, even if you do not have a history of allergy or bronchial asthma. Gynecomastia may develop while using spironolactone. Some patients have reported experiencing somnolence and dizziness. Be cautious when driving or operating machinery until you know how you respond to the initial treatment. You should avoid potassium supplements and foods high in potassium, including salt substitutes. If you are taking hydrochlorothiazide, protect your skin from the sun and have regular skin cancer screenings. Your healthcare provider should periodically check your serum electrolytes to detect possible imbalances, especially if you are elderly or have significant renal or hepatic impairments. Taking spironolactone and hydrochlorothiazide with drugs that can cause hyperkalemia may lead to severe hyperkalemia. Be aware that alcohol, barbiturates, or narcotics may increase the risk of orthostatic hypotension. Your antidiabetic drug dosage may need adjustment. Intensified electrolyte depletion, particularly hypokalemia, may occur if you are taking corticosteroids or ACTH. Caution is advised in managing patients undergoing regional or general anesthesia while being treated with spironolactone and hydrochlorothiazide. You may experience increased responsiveness to muscle relaxants. Lithium should generally not be taken with diuretics due to a high risk of lithium toxicity. Taking an NSAID can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing, and thiazide diuretics. Acetylsalicylic acid may reduce the effectiveness of spironolactone. Your healthcare provider should monitor your serum digoxin levels and adjust your dose accordingly due to an increased risk of digoxin toxicity. Hyperkalemic metabolic acidosis has been reported in patients taking spironolactone alongside cholestyramine. It is not recommended to use spironolactone in patients with prostate cancer who are being treated with abiraterone. If you are pregnant, the use of spironolactone and hydrochlorothiazide requires weighing the anticipated benefits against possible risks to the fetus. It is not recommended to use spironolactone and hydrochlorothiazide while breastfeeding. Pregnancy & Lactation Since spironolactone has been found to cause tumors in rats, you should consider whether to continue the medication, keeping in mind its importance to your health. It's not recommended to use spironolactone and hydrochlorothiazide while breastfeeding. If you do use spironolactone and hydrochlorothiazide tablets while breastfeeding, please keep the doses as low as possible. If you are pregnant, the use of spironolactone and hydrochlorothiazide requires weighing the expected benefits against the potential risks to your fetus. Potential risks include fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have been observed in adults. Be aware that spironolactone may adversely affect male sex differentiation during embryonic development. If you are pregnant, the use of spironolactone and hydrochlorothiazide requires weighing the anticipated benefits against possible hazards to your fetus. Side Effects You may experience weakness. Hypotension, including orthostatic hypotension, may occur and can be worsened by alcohol, barbiturates, narcotics, or antihypertensive medications. There is a risk of pancreatitis. You might develop jaundice, specifically intrahepatic cholestatic jaundice. Diarrhea can occur. You may experience vomiting. Sialoadenitis is a possible side effect. Cramping may happen. You might experience constipation. Gastric irritation can occur. Nausea is a potential side effect. You may experience anorexia. Acute myopia can develop. There is a risk of acute angle-closure glaucoma. Aplastic anemia is a possible side effect. You may experience agranulocytosis. Leukopenia can occur. Hemolytic anemia is a potential risk. Thrombocytopenia may happen. Anaphylactic reactions are possible. You might experience necrotizing angitis, which includes vasculitis and cutaneous vasculitis. Respiratory distress, including pneumonitis and pulmonary edema, may occur. Photosensitivity can happen. You may experience fever. Urticaria is a possible side effect. A rash may develop. Purpura can occur. Electrolyte imbalance is a potential risk. You might experience hyperglycemia. Glycosuria can occur. Hyperuricemia is a possible side effect. Muscle spasms may happen. You might experience vertigo. Paresthesias can occur. Dizziness is a potential side effect. You may experience headaches. Restlessness can happen. There is a risk of renal failure. Renal dysfunction may occur. Interstitial nephritis is a possible side effect. Erythema multiforme can develop. You might experience pruritus. Transient blurred vision may occur. Xanthopsia is a potential side effect. Gastric bleeding can happen. Ulceration may occur. Gastritis is a possible risk. Diarrhea and cramping can occur. Nausea may happen. You might experience vomiting. Gynecomastia is a potential side effect. You may have difficulty achieving or maintaining an erection. Irregular menses or amenorrhea can occur. Postmenopausal bleeding is a possible side effect. You might experience breast pain. Leukopenia, including agranulocytosis, can occur. Thrombocytopenia may happen. You may experience fever. Urticaria is a possible side effect. Maculopapular or erythematous cutaneous eruptions can occur. Anaphylactic reactions are possible. Vasculitis may happen. You might experience hyperkalemia. Electrolyte disturbances can occur. Leg cramps may happen. You might feel lethargic. Mental confusion is a potential side effect. Ataxia can occur. Dizziness is a possible side effect. You may experience headaches. Drowsiness can happen. Renal dysfunction, including renal failure, is a potential risk. Stevens-Johnson Syndrome (SJS) may occur. Toxic epidermal necrolysis (TEN) is a possible side effect. Drug rash with eosinophilia and systemic symptoms (DRESS) can occur. Alopecia may happen. You might experience pruritus. There is an increased risk of non-melanoma skin cancer. Acute angle-closure glaucoma and elevated intraocular pressure may occur, with or without a noticeable acute myopic shift and/or choroidal effusions. Somnolence is a potential side effect. Dizziness may happen. Warnings potassium supplementation should not ordinarily be given in association with spironolactone and hydrochlorothiazide therapy excessive potassium intake may cause hyperkalemia in patients receiving spironolactone and hydrochlorothiazide spironolactone and hydrochlorothiazide should not be administered concurrently with other potassium-sparing diuretics extreme caution should be exercised when spironolactone and hydrochlorothiazide tablets are given concomitantly with ACE inhibitors or indomethacin spironolactone and hydrochlorothiazide should be used with caution in patients with impaired hepatic function thiazides should be used with caution in severe renal disease thiazides may precipitate azotemia in patients with renal disease cumulative effects of the drug may develop in patients with impaired renal function sensitivity reactions to thiazides may occur in patients with or without a history of allergy or bronchial asthma gynecomastia may develop in association with the use of spironolactone somnolence and dizziness have been reported to occur in some patients caution is advised when driving or operating machinery until the response to initial treatment has been determined patients should be advised to avoid potassium supplements and foods containing high levels of potassium including salt substitutes patients taking hydrochlorothiazide should protect skin from the sun and undergo regular skin cancer screening periodic determination of serum electrolytes to detect possible electrolyte imbalance should be done at appropriate intervals, particularly in the elderly and those with significant renal or hepatic impairments concomitant administration of spironolactone and hydrochlorothiazide with drugs known to cause hyperkalemia may lead to severe hyperkalemia potentiation of orthostatic hypotension may occur with alcohol, barbiturates, or narcotics dosage adjustment of the antidiabetic drug may be required intensified electrolyte depletion, particularly hypokalemia, may occur with corticosteroids or ACTH caution should be exercised in the management of patients subjected to regional or general anesthesia while treated with spironolactone and hydrochlorothiazide possible increased responsiveness to muscle relaxants may result lithium generally should not be given with diuretics due to a high risk of lithium toxicity administration of an NSAID can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing, and thiazide diuretics acetylsalicylic acid may reduce the efficacy of spironolactone monitor serum digoxin levels and adjust dose accordingly due to increased risk of digoxin toxicity hyperkalemic metabolic acidosis has been reported in patients given spironolactone concurrently with cholestyramine concomitant use of spironolactone is not recommended in abiraterone-treated prostate cancer patients the use of spironolactone and hydrochlorothiazide in pregnant women requires that the anticipated benefit be weighed against the possible hazards to the fetus the use of spironolactone and hydrochlorothiazide during breast feeding is not recommended Pregnancy & Lactation spironolactone has been found to be tumorigenic in rats, a decision should be made whether to discontinue the drug, taking into account the importance of the drug to the mother the use of spironolactone and hydrochlorothiazide during breast feeding is not recommended if spironolactone and hydrochlorothiazide tablets are used during breast feeding, doses should be kept as low as possible the use of spironolactone and hydrochlorothiazide in pregnant women requires that the anticipated benefit be weighed against the possible hazards to the fetus the hazards include fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults spironolactone may have the potential for adversely affecting sex differentiation of the male during embryogenesis the use of spironolactone and hydrochlorothiazide in pregnant women requires that the anticipated benefit be weighed against possible hazards to the fetus Side Effects weakness hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics, or antihypertensive drugs) pancreatitis jaundice (intrahepatic cholestatic jaundice) diarrhea vomiting sialoadenitis cramping constipation gastric irritation nausea anorexia acute myopia acute angle-closure glaucoma aplasticanemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia anaphylactic reactions necrotizing angitis (vasculitis and cutaneous vasculitis) respiratory distress including pneumonitis and pulmonary edema photosensitivity fever urticaria rash purpura electrolyte imbalance hyperglycemia glycosuria hyperuricemia muscle spasm vertigo paresthesias dizziness headache restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme pruritus transient blurred vision xanthopsia gastric bleeding ulceration gastritis diarrhea and cramping nausea vomiting gynecomastia inability to achieve or maintain erection irregular menses or amenorrhea postmenopausal bleeding breast pain leukopenia (including agranulocytosis) thrombocytopenia fever urticaria maculopapular or erythematous cutaneous eruptions anaphylactic reactions vasculitis hyperkalemia electrolyte disturbances leg cramps lethargy mental confusion ataxia dizziness headache drowsiness renal dysfunction (including renal failure) Stevens-Johnson Syndrome (SJS) toxic epidermal necrolysis (TEN) drug rash with eosinophilia and systemic symptoms (DRESS) alopecia pruritus increased risk of non-melanoma skin cancer acute angle-closure glaucoma and elevated intraocular pressure with or without a noticeable acute myopic shift and/or choroidal effusions somnolence dizziness
Telmisartan and Hydrochlorothiazide Rx tablet Lifestar Pharma LLC	Popularity – score 0 out of 100 (least-viewed drug)	9 warnings	11 pregnancy and lactation warnings	9 side effects	Trend: rose 88% over the year.
Telmisartan and Hydrochlorothiazide® · First marketed 2025 · Label last revised August 20, 2025View full label details → Warnings If you find out you are pregnant, please stop taking telmisartan and hydrochlorothiazide as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. It's important to avoid exposing the fetus or newborn to these medications. Make sure to correct any volume or salt depletion before starting therapy. Be aware of signs and symptoms of low blood pressure. Your healthcare provider should monitor your renal function and potassium levels if you are at risk. Keep an eye out for any clinical signs of fluid or electrolyte imbalance. Watch for any signs of a hypersensitivity reaction. Be aware that acute myopia and secondary angle-closure glaucoma can occur. Pregnancy & Lactation Telmisartan and hydrochlorothiazide can cause harm to the fetus if you are pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please stop taking telmisartan and hydrochlorothiazide as soon as possible. High blood pressure during pregnancy raises your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for your baby of intrauterine growth restriction and intrauterine death. Using medications that affect the RAS in the second and third trimesters of pregnancy may lead to low amniotic fluid, reduced kidney function in the fetus, which can cause anuria and renal failure, underdeveloped lungs, skeletal deformities including skull hypoplasia, low blood pressure, and even death. If low amniotic fluid is detected, you should stop taking telmisartan and hydrochlorothiazide unless your healthcare provider determines it is essential for your health. Thiazides can cross the placenta, and using them during pregnancy may be linked to risks of jaundice, low platelet counts, and other potential adverse reactions in the fetus or newborn. It is advisable to avoid using hydrochlorothiazide for other conditions during pregnancy. There is currently no information about whether telmisartan and hydrochlorothiazide are present in human milk, their effects on a breastfed infant, or their impact on milk production. If you are nursing, it is recommended that you do not breastfeed while being treated with telmisartan and hydrochlorothiazide. Side Effects You may experience an upper respiratory tract infection. Dizziness can occur. Sinusitis is another possible side effect. You might have diarrhea. Fatigue may affect you. Some people report influenza-like symptoms. Nausea may occur (6.1). Be aware of the possibility of a hypersensitivity reaction (5.5). Your healthcare provider should monitor for acute myopia and secondary angle-closure glaucoma (5.6). Warnings when pregnancy is detected, discontinue telmisartan and hydrochlorothiazide as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus avoid fetal or neonatal exposure correct volume or salt depletion before initiating therapy observe for signs and symptoms of hypotension monitor renal function and potassium in susceptible patients observe for clinical signs of fluid or electrolyte imbalance hypersensitivity reaction acute myopia and secondary angle-closure glaucoma Pregnancy & Lactation telmisartan and hydrochlorothiazide can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue telmisartan and hydrochlorothiazide as soon as possible hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death use of drugs that act on the RAS in the second and third trimesters of pregnancy can result in oligohydramnios, reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death if oligohydramnios is observed, discontinue telmisartan and hydrochlorothiazide, unless it is considered lifesaving for the mother thiazides cross the placenta, and use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice, thrombocytopenia, and possible other adverse reactions the use of hydrochlorothiazide for other indications in pregnancy should be avoided there is no information regarding the presence of telmisartan and hydrochlorothiazide in human milk, the effects on the breastfed infant or the effects on milk production advise a nursing woman not to breastfeed during treatment with telmisartan and hydrochlorothiazide Side Effects upper respiratory tract infection dizziness sinusitis diarrhea fatigue influenza-like symptoms nausea (6.1) hypersensitivity Reaction (5.5) Acute Myopia and Secondary Angle-Closure Glaucoma (5.6)
Telmisartan and Hydrochlorothiazide Rx tablet Glenmark Pharmaceuticals Inc. , USA	Popularity – score 0 out of 100 (least-viewed drug)	9 warnings	11 pregnancy and lactation warnings	9 side effects	Trend: rose 88% over the year.
Telmisartan and Hydrochlorothiazide® · First marketed 2019 · Label last revised January 7, 2026View full label details → Warnings If you find out you are pregnant, please stop taking telmisartan and hydrochlorothiazide as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. It's important to avoid exposing the fetus or newborn to these medications. Make sure to correct any volume or salt depletion before starting therapy. Be aware of any signs and symptoms of low blood pressure. Your healthcare provider should monitor your renal function and potassium levels if you are at risk. Keep an eye out for any clinical signs of fluid or electrolyte imbalance. Watch for any signs of a hypersensitivity reaction. Be aware that acute myopia and secondary angle-closure glaucoma may occur. Pregnancy & Lactation Telmisartan and hydrochlorothiazide tablets can cause harm to the fetus if you are pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please stop taking telmisartan and hydrochlorothiazide tablets as soon as possible. Having high blood pressure during pregnancy raises your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for your baby, including issues like intrauterine growth restriction and intrauterine death. Using medications that affect the renin-angiotensin system in the second and third trimesters of pregnancy may lead to conditions such as oligohydramnios, reduced kidney function in the fetus, fetal lung underdevelopment, skeletal deformities, low blood pressure, and even death. If there is no suitable alternative to using medications that affect the renin-angiotensin system for your treatment, your healthcare provider should inform you about the potential risks to your baby. If oligohydramnios is detected, you should stop taking telmisartan and hydrochlorothiazide tablets, unless your healthcare provider believes it is essential for your health. Thiazides can cross the placenta, and using them during pregnancy may pose risks such as fetal or neonatal jaundice, low platelet counts, and other possible adverse reactions. It is best to avoid using hydrochlorothiazide for other conditions during pregnancy. If you are nursing, please avoid breastfeeding while you are being treated with telmisartan and hydrochlorothiazide tablets. Side Effects You may experience an upper respiratory tract infection. Dizziness can occur. Sinusitis is another possible side effect. You might have diarrhea. Fatigue may affect you. Influenza-like symptoms could arise. Nausea is something to watch for. A hypersensitivity reaction may happen. You could develop acute myopia and secondary angle-closure glaucoma. Warnings when pregnancy is detected, discontinue telmisartan and hydrochlorothiazide as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus avoid fetal or neonatal exposure correct volume or salt depletion before initiating therapy observe for signs and symptoms of hypotension monitor renal function and potassium in susceptible patients observe for clinical signs of fluid or electrolyte imbalance hypersensitivity reaction acute myopia and secondary angle-closure glaucoma Pregnancy & Lactation telmisartan and hydrochlorothiazide tablets can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue telmisartan and hydrochlorothiazide tablets as soon as possible hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death use of drugs that act on the RAS in the second and third trimesters of pregnancy can result in oligohydramnios, reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death in the unusual case that there is no appropriate alternative to therapy with drugs affecting the renin-angiotensin system for a particular patient, apprise the mother of the potential risk to the fetus if oligohydramnios is observed, discontinue telmisartan and hydrochlorothiazide tablets, unless it is considered lifesaving for the mother thiazides cross the placenta, and use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice, thrombocytopenia, and possible other adverse reactions the use of hydrochlorothiazide for other indications in pregnancy should be avoided advise a nursing woman not to breastfeed during treatment with telmisartan and hydrochlorothiazide tablets Side Effects upper respiratory tract infection dizziness sinusitis diarrhea fatigue influenza-like symptoms nausea hypersensitivity reaction acute myopia and secondary angle-closure glaucoma
Telmisartan and Hydrochlorothiazide Rx tablet Solco Healthcare LLC	Popularity – score 0 out of 100 (least-viewed drug)	9 warnings	0 pregnancy and lactation warnings	9 side effects	Trend: rose 88% over the year.
Telmisartan and Hydrochlorothiazide® · First marketed 2018 · Label last revised June 30, 2025View full label details → Warnings If you find out you are pregnant, please stop taking telmisartan and hydrochlorothiazide as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. It's important to avoid exposing the fetus or newborn to these medications. Make sure to correct any volume or salt depletion before starting therapy. Be aware of any signs and symptoms of low blood pressure. Your healthcare provider should monitor your renal function and potassium levels if you are at risk. Keep an eye out for any clinical signs of fluid or electrolyte imbalance. Watch for any signs of a hypersensitivity reaction. Be aware that acute myopia and secondary angle-closure glaucoma can occur. Pregnancy & Lactation No pregnancy & lactation warnings reported. Side Effects You may experience an upper respiratory tract infection. Dizziness can occur. Sinusitis is another possible side effect. You might have diarrhea. Fatigue may affect you. Some people report influenza-like symptoms. Nausea is also a possibility. Be aware of a hypersensitivity reaction. Your healthcare provider should monitor for acute myopia and secondary angle-closure glaucoma. Warnings when pregnancy is detected, discontinue telmisartan and hydrochlorothiazide as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus avoid fetal or neonatal exposure correct volume or salt depletion before initiating therapy observe for signs and symptoms of hypotension monitor renal function and potassium in susceptible patients observe for clinical signs of fluid or electrolyte imbalance hypersensitivity reaction acute myopia and secondary angle-closure glaucoma Pregnancy & Lactation No pregnancy & lactation warnings reported. Side Effects upper respiratory tract infection dizziness sinusitis diarrhea fatigue influenza-like symptoms nausea hypersensitivity Reaction Acute Myopia and Secondary Angle-Closure Glaucoma
Telmisartan and Hydrochlorothiazide Rx tablet Alembic Pharmaceuticals Limited	Popularity – score 0 out of 100 (least-viewed drug)	18 warnings	1 pregnancy and lactation warnings	134 side effects	Trend: rose 88% over the year.
Telmisartan and Hydrochlorothiazide® · First marketed 2014 · Label last revised January 23, 2023View full label details → Warnings If you find out you are pregnant, please stop taking telmisartan and hydrochlorothiazide as soon as possible. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase risks for both the fetus and newborn. In rare cases where there are no suitable alternatives to medications affecting the renin-angiotensin system, make sure to discuss the potential risks to your fetus with your healthcare provider. Your healthcare provider may perform serial ultrasound examinations to evaluate the intra-amniotic environment. If oligohydramnios is detected, you should discontinue telmisartan and hydrochlorothiazide unless it is deemed lifesaving for you. Infants with a history of exposure to telmisartan and hydrochlorothiazide in utero should be closely monitored for low blood pressure, reduced urine output, and high potassium levels. If you have activated renin-angiotensin systems, such as being intravascular volume- or sodium-depleted, starting antihypertensive therapy should be approached with caution. These conditions should be addressed before you take telmisartan and hydrochlorothiazide tablets. Use thiazide diuretics carefully if you have impaired liver function or progressive liver disease. Hypersensitivity reactions to hydrochlorothiazide can occur, even in those without a history of allergies or asthma, but are more common in individuals with such a history. Thiazide diuretics may worsen or trigger systemic lupus erythematosus. Generally, lithium should not be taken with thiazides. Hydrochlorothiazide can lead to an unusual reaction that causes sudden short-sightedness and acute angle-closure glaucoma. The best course of action is to stop taking hydrochlorothiazide as quickly as possible. You should avoid using potassium supplements or salt substitutes containing potassium without first consulting your prescribing physician. Lightheadedness may occur, especially during the initial days of treatment, and you should inform your prescribing physician if this happens. If you experience fainting, please stop taking telmisartan and hydrochlorothiazide tablets until you have consulted with your physician. Not drinking enough fluids, excessive sweating, diarrhea, or vomiting can lead to a significant drop in blood pressure, which may cause lightheadedness and fainting. Pregnancy & Lactation You should decide whether to continue nursing or stop taking the medication, considering how important the medication is for you. Side Effects You may experience fatigue. You might have influenza-like symptoms. Dizziness can occur. Diarrhea may happen. Nausea is a possible side effect. You could develop sinusitis. Upper respiratory tract infection is a potential concern. Impotence may be experienced. Increased sweating can occur. Flushing might happen. Allergic reactions are possible. You may have a fever. Leg pain could occur. Malaise is a potential side effect. Chest pain may happen. You might experience palpitations. Dependent edema can occur. Angina pectoris may be experienced. Leg edema is a possibility. An abnormal ECG may be detected. Hypertension could occur. Peripheral edema might happen. Insomnia is a potential side effect. Somnolence may occur. You might experience migraines. Vertigo can happen. Paresthesia may be experienced. Involuntary muscle contractions could occur. Hypoaesthesia is a possibility. Flatulence may happen. Constipation can occur. Gastritis might be experienced. You may have a dry mouth. Hemorrhoids could occur. Gastroenteritis is a potential concern. Enteritis may happen. Gastroesophageal reflux could occur. Toothache might be experienced. Non-specific gastrointestinal disorders may happen. Gout is a possibility. You might experience hypercholesterolemia. Diabetes mellitus could occur. Arthritis may be experienced. You might have arthralgia. Leg cramps can happen. Myalgia is a potential side effect. Anxiety may occur. Depression could be experienced. Nervousness might happen. Infection is a possibility. Fungal infection may occur. An abscess could develop. Otitis media might happen. Asthma is a potential concern. Rhinitis may occur. You might experience dyspnea. Epistaxis can happen. Weakness may be experienced. Pancreatitis is a possibility. Jaundice (intrahepatic cholestatic jaundice) may occur. Sialadenitis could happen. Cramping might be experienced. Gastric irritation is a potential side effect. Aplastic anemia may occur. Agranulocytosis could happen. Leukopenia is a possibility. Hemolytic anemia may occur. Thrombocytopenia could happen. Purpura might be experienced. Photosensitivity is a potential concern. Urticaria may occur. Necrotizing angiitis (vasculitis and cutaneous vasculitis) could happen. You may experience fever. Respiratory distress, including pneumonitis and pulmonary edema, is a possibility. Anaphylactic reactions may occur. Hyperglycemia could happen. Glycosuria might be experienced. Hyperuricemia is a potential concern. Muscle spasms may occur. Restlessness could happen. Renal failure is a possibility. Renal dysfunction may occur. Interstitial nephritis could happen. Erythema multiforme, including Stevens-Johnson syndrome, may occur. Exfoliative dermatitis, including toxic epidermal necrolysis, could happen. You might experience transient blurred vision. Xanthopsia may occur. Headaches can happen. Dizziness might be experienced. Asthenia is a potential side effect. Coughing may occur. Nausea is a possibility. Fatigue could happen. Weakness may be experienced. Edema might occur. Face edema is a possibility. Lower limb edema may happen. Angioneurotic edema could occur. Urticaria might be experienced. Hypersensitivity is a potential concern. Increased sweating may occur. Erythema could happen. Chest pain might be experienced. Atrial fibrillation is a possibility. Congestive heart failure may occur. Myocardial infarction could happen. You might experience increased blood pressure. Hypertension may be aggravated. Hypotension (including postural hypotension) could occur. Hyperkalemia is a potential concern. Syncope may happen. Dyspepsia could occur. Diarrhea might be experienced. Pain is a possibility. You may develop a urinary tract infection. Erectile dysfunction could happen. Back pain may occur. Abdominal pain is a potential side effect. Muscle cramps (including leg cramps) might happen. Myalgia could occur. Bradycardia is a possibility. Eosinophilia may happen. Thrombocytopenia could occur. Uric acid levels may increase. Abnormal hepatic function/liver disorder is a potential concern. Renal impairment, including acute renal failure, may occur. Anemia could happen. Increased CPK might be experienced. Anaphylactic reaction is a possibility. Tendon pain (including tendonitis, tenosynovitis) may occur. You might experience a drug eruption (toxic skin eruption mostly reported as toxicoderma, rash, and urticaria). Hypoglycemia (in diabetic patients) could happen. Angioedema (with fatal outcome) is a potential concern. Rhabdomyolysis may occur. Warnings when pregnancy is detected, discontinue telmisartan and hydrochlorothiazide as soon as possible use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death in the unusual case that there is no appropriate alternative to therapy with drugs affecting the renin-angiotensin system for a particular patient, apprise the mother of the potential risk to the fetus perform serial ultrasound examinations to assess the intra-amniotic environment if oligohydramnios is observed, discontinue telmisartan and hydrochlorothiazide, unless it is considered lifesaving for the mother closely observe infants with histories of in utero exposure to telmisartan and hydrochlorothiazide for hypotension, oliguria, and hyperkalemia initiation of antihypertensive therapy in patients whose renin-angiotensin system are activated such as patients who are intravascular volume- or sodium-depleted should only be approached cautiously these conditions should be corrected prior to administration of telmisartan and hydrochlorothiazide tablets thiazide diuretics should be used with caution in patients with impaired hepatic function or progressive liver disease hypersensitivity reactions to hydrochlorothiazide may occur in patients with or without a history of allergy or bronchial asthma, but are more likely in patients with such a history thiazide diuretics have been reported to cause exacerbation or activation of systemic lupus erythematosus lithium generally should not be given with thiazides hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma the primary treatment is to discontinue hydrochlorothiazide as rapidly as possible patients should be told not to use potassium supplements or salt substitutes that contain potassium without consulting the prescribing physician lightheadedness can occur, especially during the first days of therapy, and should be reported to the prescribing physician if syncope occurs, telmisartan and hydrochlorothiazide tablets should be discontinued until the physician has been consulted inadequate fluid intake, excessive perspiration, diarrhea, or vomiting can lead to an excessive fall in blood pressure, with the same consequences of lightheadedness and possible syncope Pregnancy & Lactation a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother Side Effects fatigue influenza-like symptoms dizziness diarrhea nausea sinusitis upper respiratory tract infection impotence increased sweating flushing allergy fever leg pain malaise chest pain palpitation dependent edema angina pectoris leg edema abnormal ECG hypertension peripheral edema insomnia somnolence migraine vertigo paresthesia involuntary muscle contractions hypoaesthesia flatulence constipation gastritis dry mouth hemorrhoids gastroenteritis enteritis gastroesophageal reflux toothache non-specific gastrointestinal disorders gout hypercholesterolemia diabetes mellitus arthritis arthralgia leg cramps myalgia anxiety depression nervousness infection fungal infection abscess otitis media asthma rhinitis dyspnea epistaxis weakness pancreatitis jaundice (intrahepatic cholestatic jaundice) sialadenitis cramping gastric irritation aplastic anemia agranulocytosis leukopenia hemolytic anemia thrombocytopenia purpura photosensitivity urticaria necrotizing angiitis (vasculitis and cutaneous vasculitis) fever respiratory distress including pneumonitis and pulmonary edema anaphylactic reactions hyperglycemia glycosuria hyperuricemia muscle spasm restlessness renal failure renal dysfunction interstitial nephritis erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis transient blurred vision xanthopsia headache dizziness asthenia coughing nausea fatigue weakness edema face edema lower limb edema angioneurotic edema urticaria hypersensitivity sweating increased erythema chest pain atrial fibrillation congestive heart failure myocardial infarction blood pressure increased hypertension aggravated hypotension (including postural hypotension) hyperkalemia syncope dyspepsia diarrhea pain urinary tract infection erectile dysfunction back pain abdominal pain muscle cramps (including leg cramps) myalgia bradycardia eosinophilia thrombocytopenia uric acid increased abnormal hepatic function/liver disorder renal impairment including acute renal failure anemia increased CPK anaphylactic reaction tendon pain (including tendonitis, tenosynovitis) drug eruption (toxic skin eruption mostly reported as toxicoderma, rash, and urticaria) hypoglycemia (in diabetic patients) angioedema (with fatal outcome) rhabdomyolysis
Telmisartan and Hydrochlorothiazide Rx tablet Aurobindo Pharma Limited	Popularity – score 0 out of 100 (least-viewed drug)	9 warnings	12 pregnancy and lactation warnings	9 side effects	Trend: rose 88% over the year.
Telmisartan and Hydrochlorothiazide® · First marketed 2016 · Label last revised June 20, 2024View full label details → Warnings If you find out you are pregnant, please stop taking telmisartan and hydrochlorothiazide as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. It's important to avoid exposing the fetus or newborn to these medications. Make sure to correct any volume or salt depletion before starting therapy. Be aware of signs and symptoms of low blood pressure. Your healthcare provider should monitor your renal function and potassium levels if you are at risk. Keep an eye out for any clinical signs of fluid or electrolyte imbalance. Watch for any signs of a hypersensitivity reaction. Be alert for symptoms of acute myopia and secondary angle-closure glaucoma. Pregnancy & Lactation Telmisartan and hydrochlorothiazide can cause harm to the fetus if you are pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please stop taking telmisartan and hydrochlorothiazide as soon as possible. High blood pressure during pregnancy raises your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for your baby of intrauterine growth restriction and intrauterine death. Taking medications that affect the RAS in the second and third trimesters of pregnancy may lead to low amniotic fluid, reduced kidney function in the fetus, fetal lung development issues, skeletal deformities, low blood pressure, and even death. If low amniotic fluid is detected, you should stop taking telmisartan and hydrochlorothiazide unless your healthcare provider believes it is essential for your health. Your healthcare provider should closely monitor infants who were exposed to telmisartan and hydrochlorothiazide in utero for signs of low blood pressure, reduced urine output, and high potassium levels. Thiazides can cross the placenta, and using thiazides during pregnancy may increase the risk of jaundice, low platelet counts, and other adverse reactions that can also occur in adults. It is best to avoid using hydrochlorothiazide for other conditions during pregnancy. If you are nursing, please do not breastfeed while you are being treated with telmisartan and hydrochlorothiazide. There is not enough information to understand how hydrochlorothiazide affects breastfed infants or its impact on milk production. Side Effects You may experience an upper respiratory tract infection. Dizziness can occur. Sinusitis is another possible side effect. You might have diarrhea. Fatigue may affect you. Influenza-like symptoms could arise. Nausea is something to watch for. A hypersensitivity reaction may happen. Be aware of the risk of acute myopia and secondary angle-closure glaucoma. Warnings when pregnancy is detected, discontinue telmisartan and hydrochlorothiazide as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus avoid fetal or neonatal exposure correct volume or salt depletion before initiating therapy observe for signs and symptoms of hypotension monitor renal function and potassium in susceptible patients observe for clinical signs of fluid or electrolyte imbalance hypersensitivity reaction acute myopia and secondary angle-closure glaucoma Pregnancy & Lactation telmisartan and hydrochlorothiazide can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue telmisartan and hydrochlorothiazide as soon as possible hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death use of drugs that act on the RAS in the second and third trimesters of pregnancy can result in oligohydramnios, reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death if oligohydramnios is observed, discontinue telmisartan and hydrochlorothiazide, unless it is considered lifesaving for the mother closely observe infants with histories of in utero exposure to telmisartan and hydrochlorothiazide for hypotension, oliguria, and hyperkalemia thiazides cross the placenta, and use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice, thrombocytopenia, and possible other adverse reactions that have occurred in adults the use of hydrochlorothiazide for other indications in pregnancy should be avoided advise a nursing woman not to breastfeed during treatment with telmisartan and hydrochlorothiazide there is insufficient information to determine the effects of hydrochlorothiazide on the breastfed infant or the effects of hydrochlorothiazide on milk production Side Effects upper respiratory tract infection dizziness sinusitis diarrhea fatigue influenza-like symptoms nausea hypersensitivity Reaction Acute Myopia and Secondary Angle-Closure Glaucoma
Telmisartan and Hydrochlorothiazide Rx tablet Lupin Pharmaceuticals, Inc.	Popularity – score 0 out of 100 (least-viewed drug)	9 warnings	11 pregnancy and lactation warnings	9 side effects	Trend: rose 88% over the year.
Telmisartan and Hydrochlorothiazide® · First marketed 2014 · Label last revised January 9, 2026View full label details → Warnings If you find out you are pregnant, please stop taking telmisartan and hydrochlorothiazide tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. It's important to avoid exposing the fetus or newborn to these medications. Make sure to correct any volume or salt depletion before starting therapy. Be aware of signs and symptoms of low blood pressure. Your healthcare provider should monitor your renal function and potassium levels if you are at risk. Keep an eye out for any clinical signs of fluid or electrolyte imbalance. Watch for any signs of a hypersensitivity reaction. Be alert for symptoms of acute myopia and secondary angle-closure glaucoma. Pregnancy & Lactation Telmisartan and hydrochlorothiazide tablets can cause harm to the fetus if you are pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please stop taking telmisartan and hydrochlorothiazide tablets as soon as possible. Having high blood pressure during pregnancy raises your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for your baby, including issues like intrauterine growth restriction and intrauterine death. Using medications that affect the RAS in the second and third trimesters of pregnancy may lead to low amniotic fluid, reduced kidney function in the fetus, lung development issues, skeletal deformities, low blood pressure, and even death. If low amniotic fluid is detected, you should stop taking telmisartan and hydrochlorothiazide tablets unless your healthcare provider determines it is necessary for your health. Thiazides can cross the placenta, and using them during pregnancy may be linked to risks such as fetal or neonatal jaundice, low platelet counts, and other adverse reactions that have been seen in adults. It is best to avoid using hydrochlorothiazide for other conditions during pregnancy. There is no information available about whether telmisartan and hydrochlorothiazide tablets or telmisartan are present in human milk, or their effects on a breastfed infant or milk production. If you are nursing, it is advisable not to breastfeed while being treated with telmisartan and hydrochlorothiazide tablets. Side Effects You may experience an upper respiratory tract infection. Dizziness can occur. Sinusitis is another possible side effect. You might have diarrhea. Fatigue may affect you. Some people report influenza-like symptoms. Nausea is also a possibility. Be aware of a hypersensitivity reaction. Your healthcare provider should monitor you for acute myopia and secondary angle-closure glaucoma. Warnings when pregnancy is detected, discontinue telmisartan and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus avoid fetal or neonatal exposure correct volume or salt depletion before initiating therapy observe for signs and symptoms of hypotension monitor renal function and potassium in susceptible patients observe for clinical signs of fluid or electrolyte imbalance hypersensitivity reaction acute myopia and secondary angle-closure glaucoma Pregnancy & Lactation telmisartan and hydrochlorothiazide tablets can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue telmisartan and hydrochlorothiazide tablets as soon as possible hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death use of drugs that act on the RAS in the second and third trimesters of pregnancy can result in oligohydramnios, reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death if oligohydramnios is observed, discontinue telmisartan and hydrochlorothiazide tablets, unless it is considered lifesaving for the mother thiazides cross the placenta, and use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice, thrombocytopenia, and possible other adverse reactions that have occurred in adults the use of hydrochlorothiazide for other indications in pregnancy should be avoided there is no information regarding the presence of telmisartan and hydrochlorothiazide tablets or telmisartan in human milk, the effects on the breastfed infant or the effects on milk production advise a nursing woman not to breastfeed during treatment with telmisartan and hydrochlorothiazide tablets Side Effects upper respiratory tract infection dizziness sinusitis diarrhea fatigue influenza-like symptoms nausea hypersensitivity Reaction Acute Myopia and Secondary Angle-Closure Glaucoma
Telmisartan and Hydrochlorothiazide Rx tablet Alembic Pharmaceuticals Inc.	Popularity – score 0 out of 100 (least-viewed drug)	9 warnings	11 pregnancy and lactation warnings	7 side effects	Trend: rose 88% over the year.
Telmisartan and Hydrochlorothiazide® · First marketed 2016 · Label last revised September 15, 2023View full label details → Warnings If you find out you are pregnant, please stop taking telmisartan and hydrochlorothiazide as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. It's important to avoid exposing the fetus or newborn to these medications. Make sure to correct any volume or salt depletion before starting therapy. Be aware of signs and symptoms of low blood pressure. Your healthcare provider should monitor your renal function and potassium levels if you are at risk. Keep an eye out for any clinical signs of fluid or electrolyte imbalance. Watch for any signs of a hypersensitivity reaction. Be aware that acute myopia and secondary angle-closure glaucoma can occur. Pregnancy & Lactation Telmisartan and hydrochlorothiazide tablets can cause harm to the fetus if you take them while pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please stop taking telmisartan and hydrochlorothiazide tablets as soon as possible. High blood pressure during pregnancy raises your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for your baby, including issues like intrauterine growth restriction and intrauterine death. Taking medications that affect the RAS in the second and third trimesters of pregnancy may lead to low amniotic fluid, reduced kidney function in the fetus, lung development issues, skeletal deformities, low blood pressure, and even death. If you are taking telmisartan and hydrochlorothiazide tablets during pregnancy, your healthcare provider should perform regular ultrasound examinations to monitor the environment around the fetus. If low amniotic fluid is detected, your healthcare provider may recommend stopping telmisartan and hydrochlorothiazide tablets, unless they are deemed essential for your health. Infants who were exposed to telmisartan and hydrochlorothiazide tablets in utero should be closely monitored for low blood pressure, reduced urine output, and high potassium levels. Thiazides can cross the placenta, and using them during pregnancy may increase the risk of fetal or neonatal jaundice, low platelet counts, and other potential adverse reactions. It's best to avoid using hydrochlorothiazide for other conditions during pregnancy. Side Effects You may experience an upper respiratory tract infection. Dizziness can occur. You might develop sinusitis. Diarrhea is a possible side effect. Fatigue may affect you. You could have influenza-like symptoms. Nausea is another potential side effect. Warnings when pregnancy is detected, discontinue telmisartan and hydrochlorothiazide as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus avoid fetal or neonatal exposure correct volume or salt depletion before initiating therapy observe for signs and symptoms of hypotension monitor renal function and potassium in susceptible patients observe for clinical signs of fluid or electrolyte imbalance hypersensitivity reaction acute myopia and secondary angle-closure glaucoma Pregnancy & Lactation telmisartan and hydrochlorothiazide tablets can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected, discontinue telmisartan and hydrochlorothiazide tablets as soon as possible hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death use of drugs that act on the RAS in the second and third trimesters of pregnancy can result in oligohydramnios, reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death in patients taking telmisartan and hydrochlorothiazide tablets during pregnancy, perform serial ultrasound examinations to assess the intra-amniotic environment if oligohydramnios is observed, discontinue telmisartan and hydrochlorothiazide tablets, unless it is considered lifesaving for the mother closely observe infants with histories of in utero exposure to telmisartan and hydrochlorothiazide tablets for hypotension, oliguria, and hyperkalemia thiazides cross the placenta, and use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice, thrombocytopenia, and possible other adverse reactions the use of hydrochlorothiazide for other indications in pregnancy should be avoided Side Effects upper respiratory tract infection dizziness sinusitis diarrhea fatigue influenza-like symptoms nausea
Triamterene and Hydrochlorothiazide Rx tablet Zydus Lifesciences Limited	Popularity – score 0 out of 100 (least-viewed drug)	19 warnings	4 pregnancy and lactation warnings	56 side effects	Trend: was flat over 11 months.
Triamterene and Hydrochlorothiazide® · First marketed 2018 · Label last revised August 31, 2023View full label details → Warnings You may experience an abnormal elevation of serum potassium levels with all potassium-conserving diuretic combinations. Hyperkalemia is more likely to occur if you have renal impairment, diabetes, or if you are elderly or severely ill. Your healthcare provider must monitor your serum potassium levels at frequent intervals, especially when you first start taking triamterene and hydrochlorothiazide. If you are receiving triamterene and hydrochlorothiazide, your healthcare provider should carefully monitor you for fluid or electrolyte imbalances. Your healthcare provider should perform serum electrolyte determinations at appropriate intervals to detect any possible electrolyte imbalance. Serum and urine electrolyte determinations are especially important and should be frequently performed if you are vomiting or receiving parenteral fluids. Warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting. You should use triamterene and hydrochlorothiazide with caution if you have impaired hepatic function or progressive liver disease. Use triamterene and hydrochlorothiazide with caution if you have a history of renal lithiasis. Triamterene is a weak folic acid antagonist and may contribute to the appearance of megaloblastosis if your folic acid stores are decreased. Hyperuricemia may occur, or acute gout may be triggered in certain patients receiving thiazide therapy. Sensitivity reactions to thiazides may occur, even if you do not have a history of allergy or bronchial asthma. There have been reports of possible exacerbation or activation of systemic lupus erythematosus by thiazides. Caution is advised when you are administered non-steroidal anti-inflammatory agents with triamterene and hydrochlorothiazide. You should use potassium-sparing agents very cautiously, if at all, in conjunction with angiotensin-converting enzyme inhibitors due to a greatly increased risk of hyperkalemia. The safe use of triamterene and hydrochlorothiazide during pregnancy has not been established, as there are no adequate and well-controlled studies in pregnant women. If you are pregnant, the use of thiazides and triamterene requires weighing the anticipated benefits against possible hazards to the fetus. If the combination drug product is deemed essential, you should stop nursing. Safety and effectiveness in pediatric patients have not been established. Pregnancy & Lactation The safe use of triamterene and hydrochlorothiazide during pregnancy has not been established, as there are no adequate and well-controlled studies involving pregnant women. You should use triamterene and hydrochlorothiazide during pregnancy only if the potential benefits outweigh the risks to your fetus. This medication should be used during pregnancy only if it is clearly necessary. If your healthcare provider determines that the combination drug is essential, you should stop nursing. Side Effects jaundice (intrahepatic cholestatic jaundice) pancreatitis nausea changes in appetite altered taste vomiting diarrhea constipation loss of appetite gastric irritation cramping drowsiness and fatigue insomnia headache dizziness dry mouth depression anxiety vertigo restlessness tingling sensations rapid heartbeat shortness of breath and chest pain orthostatic hypotension (this may be worsened by alcohol, barbiturates, or narcotics) acute renal failure acute interstitial nephritis renal stones made of triamterene along with other materials urine discoloration leukopenia agranulocytosis thrombocytopenia aplastic anemia hemolytic anemia megaloblastosis xanthopsia temporary blurred vision anaphylaxis photosensitivity rash hives purpura necrotizing angiitis (vasculitis, cutaneous vasculitis) fever respiratory distress including pneumonitis muscle cramps and weakness decreased sexual performance sialadenitis high potassium levels low potassium levels low sodium levels low magnesium levels low chloride levels high blood sugar levels sugar in urine diabetes mellitus elevated liver enzymes Warnings abnormal elevation of serum potassium levels can occur with all potassium-conserving diuretic combinations hyperkalemia is more likely to occur in patients with renal impairment, diabetes, or elderly or severely ill patients serum potassium levels must be monitored at frequent intervals especially in patients first receiving triamterene and hydrochlorothiazide patients receiving triamterene and hydrochlorothiazide should be carefully monitored for fluid or electrolyte imbalances determination of serum electrolytes to detect possible electrolyte imbalance should be performed at appropriate intervals serum and urine electrolyte determinations are especially important and should be frequently performed when the patient is vomiting or receiving parenteral fluids warning signs or symptoms of fluid and electrolyte imbalance include: dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia and gastrointestinal disturbances such as nausea and vomiting triamterene and hydrochlorothiazide should be used with caution in patients with impaired hepatic function or progressive liver disease triamterene and hydrochlorothiazide should be used with caution in patients with histories of renal lithiasis triamterene is a weak folic acid antagonist and may contribute to the appearance of megaloblastosis in instances where folic acid stores are decreased hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazide therapy sensitivity reactions to thiazides may occur in patients with or without a history of allergy or bronchial asthma possible exacerbation or activation of systemic lupus erythematosus by thiazides has been reported caution is therefore advised when administering non-steroidal anti-inflammatory agents with triamterene and hydrochlorothiazide potassium-sparing agents should be used very cautiously, if at all, in conjunction with angiotensin-converting enzyme inhibitors due to a greatly increased risk of hyperkalemia the safe use of triamterene and hydrochlorothiazide in pregnancy has not been established since there are no adequate and well controlled studies with triamterene and hydrochlorothiazide in pregnant women the use of thiazides and triamterene in pregnant women requires that the anticipated benefits be weighed against possible hazards to the fetus if use of the combination drug product is deemed essential, the patient should stop nursing safety and effectiveness in pediatric patients have not been established Pregnancy & Lactation the safe use of triamterene and hydrochlorothiazide in pregnancy has not been established since there are no adequate and well controlled studies with triamterene and hydrochlorothiazide in pregnant women triamterene and hydrochlorothiazide should be used during pregnancy only if the potential benefit justifies the risk to the fetus this drug should be used during pregnancy only if clearly needed if use of the combination drug product is deemed essential, the patient should stop nursing Side Effects jaundice (intrahepatic cholestatic jaundice) pancreatitis nausea appetite disturbance taste alteration vomiting diarrhea constipation anorexia gastric irritation cramping drowsiness and fatigue insomnia headache dizziness dry mouth depression anxiety vertigo restlessness paresthesias tachycardia shortness of breath and chest pain orthostatic hypotension (may be aggravated by alcohol, barbiturates or narcotics) acute renal failure acute interstitial nephritis renal stones composed of triamterene in association with other calculus materials urine discoloration leukopenia agranulocytosis thrombocytopenia aplastic anemia hemolytic anemia megaloblastosis xanthopsia transient blurred vision anaphylaxis photosensitivity rash urticaria purpura necrotizing angiitis (vasculitis, cutaneous vasculitis) fever respiratory distress including pneumonitis muscle cramps and weakness decreased sexual performance sialadenitis hyperkalemia hypokalemia hyponatremia hypomagnesemia hypochloremia hyperglycemia glycosuria diabetes mellitus elevated liver enzymes
Triamterene and Hydrochlorothiazide Rx capsule Chartwell RX, LLC	Popularity – score 0 out of 100 (least-viewed drug)	16 warnings	8 pregnancy and lactation warnings	56 side effects	Trend: was flat over 11 months.
Triamterene and Hydrochlorothiazide® · First marketed 2011 · Label last revised December 10, 2025View full label details → Warnings You should exercise caution when taking triamterene and hydrochlorothiazide capsules if you have diabetes. If you have impaired hepatic function, thiazides should be used carefully. Be cautious with triamterene and hydrochlorothiazide capsules if you have a history of renal stones. If you develop hypokalemia, consider taking potassium supplements or increasing your intake of potassium-rich foods. Your healthcare provider may need to monitor your serum potassium levels closely, especially if you are taking digitalis or have a history of cardiac arrhythmias. If serious hypokalemia occurs, you should discontinue triamterene and hydrochlorothiazide capsules. Serum electrolyte levels should be checked, especially if you are experiencing excessive vomiting or receiving fluids through an IV. Watch for warning signs of possible fluid and electrolyte imbalance, such as dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pain or cramps, muscular fatigue, low blood pressure, reduced urine output, rapid heartbeat, and gastrointestinal symptoms. Be careful when taking nonsteroidal anti-inflammatory agents with triamterene and hydrochlorothiazide capsules. You generally should not take lithium with diuretics, as they can reduce its clearance and increase the risk of lithium toxicity. If you are undergoing surgery, be cautious, as thiazides can enhance the paralyzing effect of nondepolarizing muscle relaxants. The safety of triamterene and hydrochlorothiazide capsules during pregnancy has not been established. You should use triamterene and hydrochlorothiazide capsules during pregnancy only if the potential benefits outweigh the risks to your fetus. When considering thiazides and triamterene during pregnancy, weigh the anticipated benefits against possible risks to the fetus. If the combination drug is essential, you should stop nursing. The safety and effectiveness of this medication in children have not been established. Pregnancy & Lactation The safe use of triamterene and hydrochlorothiazide capsules during pregnancy has not been established, as there are no adequate and well-controlled studies involving pregnant women. You should use triamterene and hydrochlorothiazide capsules during pregnancy only if the potential benefits outweigh the risks to your fetus. This medication should only be used during pregnancy if it is clearly necessary. When considering the use of thiazides and triamterene in pregnant women, it's important to weigh the anticipated benefits against any possible risks to the fetus. The effects of thiazides and triamterene in combination have not been studied in nursing mothers. Triamterene may appear in animal milk, and this could also happen in humans. Thiazides are excreted in human breast milk. If the use of this combination drug is deemed essential, you should stop nursing. Side Effects You may experience anaphylaxis. You might develop a rash. Urticaria could occur. There may be reactions similar to subacute cutaneous lupus erythematosus. You could experience photosensitivity. Arrhythmia is a possible side effect. Postural hypotension may happen. You could develop diabetes mellitus. Hyperkalemia might occur. Hypokalemia is a potential side effect. You may experience hyponatremia. Acidosis could occur. Hypercalcemia is a possibility. You might experience hyperglycemia. Glycosuria could happen. Hyperuricemia may occur. Hypochloremia is a potential side effect. You might experience jaundice and/or liver enzyme abnormalities. Pancreatitis could occur. Nausea and vomiting may happen. You might experience diarrhea. Constipation is a possible side effect. You may have abdominal pain. Acute renal failure is a rare possibility (one case of irreversible renal failure has been reported). Interstitial nephritis could occur. You might develop renal stones primarily composed of triamterene. Elevated BUN and serum creatinine may occur. Abnormal urinary sediment could be present. You might experience leukopenia. Thrombocytopenia and purpura are potential side effects. Megaloblastic anemia could occur. You may experience muscle cramps. Weakness is a possible side effect. You might feel fatigued. Dizziness could occur. You may experience headaches. Dry mouth is a potential side effect. Impotence might occur. Sialadenitis could happen. You may experience paresthesias. Vertigo is a possibility. Xanthopsia might occur. Transient blurred vision could happen. Allergic pneumonitis is a potential side effect. You might experience pulmonary edema. Respiratory distress could occur. Necrotizing vasculitis is a possibility. Exacerbation of lupus may happen. Aplastic anemia could occur. Agranulocytosis is a potential side effect. Hemolytic anemia might occur. Thrombocytopenia and pancreatitis may rarely occur in newborns whose mothers received thiazides during pregnancy. Erythema multiforme, including Stevens-Johnson syndrome, could happen. Exfoliative dermatitis, including toxic epidermal necrolysis, is a possibility. You may have an increased risk of non-melanoma skin cancer. There is an increased risk for squamous cell carcinoma (SCC) in white patients taking large cumulative doses. Warnings caution should be exercised when administering triamterene and hydrochlorothiazide capsules to patients with diabetes thiazides should be used with caution in patients with impaired hepatic function triamterene and hydrochlorothiazide capsules should be used with caution in patients with a history of renal stones corrective measures should be taken such as potassium supplementation or increased intake of potassium-rich foods if hypokalemia develops institute measures cautiously with frequent determinations of serum potassium levels, especially in patients receiving digitalis or with a history of cardiac arrhythmias discontinue triamterene and hydrochlorothiazide capsules if serious hypokalemia is demonstrated serum determinations of electrolytes should be performed and are particularly important if the patient is vomiting excessively or receiving fluids parenterally possible fluid and electrolyte imbalance may be indicated by warning signs such as: dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pain or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal symptoms caution is advised in administering nonsteroidal anti-inflammatory agents with triamterene and hydrochlorothiazide capsules lithium generally should not be given with diuretics because they reduce its renal clearance and increase the risk of lithium toxicity caution should be observed in patients undergoing surgery due to thiazides increasing the paralyzing effect of nondepolarizing muscle relaxants the safe use of triamterene and hydrochlorothiazide capsules in pregnancy has not been established triamterene and hydrochlorothiazide capsules should be used during pregnancy only if the potential benefit justifies the risk to the fetus the use of thiazides and triamterene in pregnant women requires that the anticipated benefit be weighed against possible hazards to the fetus if use of the combination drug product is deemed essential, the patient should stop nursing safety and effectiveness in pediatric patients have not been established Pregnancy & Lactation the safe use of triamterene and hydrochlorothiazide capsules in pregnancy has not been established since there are no adequate and well-controlled studies with triamterene and hydrochlorothiazide capsules in pregnant women triamterene and hydrochlorothiazide capsules should be used during pregnancy only if the potential benefit justifies the risk to the fetus this drug should be used during pregnancy only if clearly needed the use of thiazides and triamterene in pregnant women requires that the anticipated benefit be weighed against possible hazards to the fetus thiazides and triamterene in combination have not been studied in nursing mothers triamterene appears in animal milk; this may occur in humans thiazides are excreted in human breast milk if use of the combination drug product is deemed essential, the patient should stop nursing Side Effects anaphylaxis rash urticaria subacute cutaneous lupus erythematosus-like reactions photosensitivity arrhythmia postural hypotension diabetes mellitus hyperkalemia hypokalemia hyponatremia acidosis hypercalcemia hyperglycemia glycosuria hyperuricemia hypochloremia jaundice and/or liver enzyme abnormalities pancreatitis nausea and vomiting diarrhea constipation abdominal pain acute renal failure (one case of irreversible renal failure has been reported) interstitial nephritis renal stones composed primarily of triamterene elevated BUN and serum creatinine abnormal urinary sediment leukopenia thrombocytopenia and purpura megaloblastic anemia muscle cramps weakness fatigue dizziness headache dry mouth impotence sialadenitis paresthesias vertigo xanthopsia transient blurred vision allergic pneumonitis pulmonary edema respiratory distress necrotizing vasculitis exacerbation of lupus aplastic anemia agranulocytosis hemolytic anemia thrombocytopenia and pancreatitis–rarely, in newborns whose mothers have received thiazides during pregnancy erythema multiforme, including Stevens-Johnson syndrome exfoliative dermatitis, including toxic epidermal necrolysis increased risk of non-melanoma skin cancer increased risk for squamous cell carcinoma (SCC) in white patients taking large cumulative doses
Triamterene and Hydrochlorothiazide Rx tablet REMEDYREPACK INC.	Popularity – score 0 out of 100 (least-viewed drug)	31 warnings	6 pregnancy and lactation warnings	57 side effects	Trend: was flat over 11 months.
Triamterene and Hydrochlorothiazide® · First marketed 2018 · Label last revised September 4, 2025View full label details → Warnings Hyperkalemia, which is an abnormal elevation of serum potassium levels (greater than or equal to 5.5 mEq/liter), can occur with all potassium-conserving diuretic combinations, including triamterene and hydrochlorothiazide. You are more likely to experience hyperkalemia if you have renal impairment, diabetes (even without evidence of renal impairment), or if you are elderly or severely ill. Your healthcare provider must monitor serum potassium levels at frequent intervals, especially when you first start taking triamterene and hydrochlorothiazide, when dosages are changed, or if you have any illness that may affect renal function. If you suspect hyperkalemia (warning signs include paresthesias, muscular weakness, fatigue, flaccid paralysis of the extremities, bradycardia, and shock), an electrocardiogram (ECG) should be obtained. If hyperkalemia is confirmed, you should discontinue triamterene and hydrochlorothiazide immediately, and a thiazide alone should be substituted. If you have mild renal functional impairment, you should not take this drug without frequent and ongoing monitoring of your serum electrolytes. Cumulative drug effects may be observed if you have impaired renal function. You should avoid triamterene and hydrochlorothiazide if you have diabetes. If you must use it, your serum electrolytes need to be monitored frequently. Use triamterene and hydrochlorothiazide cautiously, if at all, with angiotensin-converting enzyme (ACE) inhibitors. Potassium-conserving therapy should also be avoided if you are severely ill and at risk for respiratory or metabolic acidosis. Frequent evaluations of acid/base balance and serum electrolytes are necessary if you are using triamterene and hydrochlorothiazide. Hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma. Symptoms include an acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of starting the drug. If left untreated, acute angle-closure glaucoma can lead to permanent vision loss. The primary treatment is to discontinue hydrochlorothiazide as quickly as possible. Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. If you are receiving triamterene and hydrochlorothiazide, your healthcare provider should carefully monitor you for fluid or electrolyte imbalances. Your healthcare provider should perform serum electrolyte tests at appropriate intervals to detect any possible imbalances. Warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting. Use triamterene and hydrochlorothiazide with caution if you have impaired hepatic function or progressive liver disease. Use triamterene and hydrochlorothiazide with caution if you have a history of renal lithiasis. Triamterene is a weak folic acid antagonist and may contribute to the appearance of megaloblastosis if your folic acid stores are decreased. Hyperuricemia may occur, or acute gout may be triggered in certain patients receiving thiazide therapy. Sensitivity reactions to thiazides may occur in patients with or without a history of allergy or bronchial asthma. There have been reports of possible exacerbation or activation of systemic lupus erythematosus by thiazides. The safe use of triamterene and hydrochlorothiazide tablets during pregnancy has not been established, as there are no adequate and well-controlled studies in pregnant women. If you are pregnant, the use of thiazides and triamterene requires weighing the anticipated benefits against possible hazards to the fetus. Thiazides and triamterene can cross the placental barrier and appear in cord blood. If the combination drug is deemed essential, you should stop nursing. Safety and effectiveness in pediatric patients have not been established. Pregnancy & Lactation The safe use of triamterene and hydrochlorothiazide tablets during pregnancy has not been established, as there are no adequate and well-controlled studies involving pregnant women. You should use triamterene and hydrochlorothiazide tablets during pregnancy only if the potential benefits outweigh the risks to your fetus. This medication should only be used during pregnancy if it is clearly necessary. When considering the use of thiazides and triamterene in pregnant women, it's important to weigh the anticipated benefits against any possible risks to the fetus. These risks may include fetal or neonatal jaundice, pancreatitis, thrombocytopenia, and potentially other adverse reactions that have been observed in adults. If the combination drug is deemed essential, you should stop nursing. Side Effects jaundice (intrahepatic cholestatic jaundice) pancreatitis nausea changes in appetite altered taste vomiting diarrhea constipation loss of appetite gastric irritation cramping drowsiness and fatigue insomnia headache dizziness dry mouth depression anxiety vertigo restlessness tingling sensations rapid heartbeat shortness of breath and chest pain orthostatic hypotension (this may be worsened by alcohol, barbiturates, or narcotics) acute renal failure acute interstitial nephritis renal stones made of triamterene along with other materials urine discoloration leukopenia agranulocytosis thrombocytopenia aplastic anemia hemolytic anemia and megaloblastosis xanthopsia temporary blurred vision anaphylaxis photosensitivity rash hives purpura necrotizing angiitis (vasculitis, cutaneous vasculitis) fever respiratory distress including pneumonitis muscle cramps and weakness decreased sexual performance sialadenitis high potassium levels low potassium levels low sodium levels low magnesium levels low chloride levels high blood sugar sugar in urine diabetes mellitus elevated liver enzymes acute transient myopia acute angle-closure glaucoma Warnings hyperkalemia: abnormal elevation of serum potassium levels (greater than or equal to 5.5 mEq/liter) can occur with all potassium-conserving diuretic combinations, including triamterene and hydrochlorothiazide hyperkalemia is more likely to occur in patients with renal impairment, diabetes (even without evidence of renal impairment), or elderly or severely ill patients serum potassium levels must be monitored at frequent intervals especially in patients first receiving triamterene and hydrochlorothiazide, when dosages are changed or with any illness that may influence renal function if hyperkalemia is suspected, (warning signs include paresthesias, muscular weakness, fatigue, flaccid paralysis of the extremities, bradycardia and shock), an electrocardiogram (ECG) should be obtained if hyperkalemia is present, triamterene and hydrochlorothiazide should be discontinued immediately and a thiazide alone should be substituted patients with mild renal functional impairment should not receive this drug without frequent and continuing monitoring of serum electrolytes cumulative drug effects may be observed in patients with impaired renal function triamterene and hydrochlorothiazide should be avoided in diabetic patients if it is employed, serum electrolytes must be frequently monitored triamterene and hydrochlorothiazide should be used cautiously, if at all, with angiotensin-converting enzyme (ACE) inhibitors potassium-conserving therapy should also be avoided in severely ill patients in whom respiratory or metabolic acidosis may occur frequent evaluations of acid/base balance and serum electrolytes are necessary if triamterene and hydrochlorothiazide is employed hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma symptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiation untreated acute angle-closure glaucoma can lead to permanent vision loss the primary treatment is to discontinue hydrochlorothiazide as rapidly as possible risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy patients receiving triamterene and hydrochlorothiazide should be carefully monitored for fluid or electrolyte imbalances determination of serum electrolytes to detect possible electrolyte imbalance should be performed at appropriate intervals warning signs or symptoms of fluid and electrolyte imbalance include: dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting triamterene and hydrochlorothiazide should be used with caution in patients with impaired hepatic function or progressive liver disease triamterene and hydrochlorothiazide should be used with caution in patients with histories of renal lithiasis triamterene is a weak folic acid antagonist and may contribute to the appearance of megaloblastosis in instances where folic acid stores are decreased hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazide therapy sensitivity reactions to thiazides may occur in patients with or without a history of allergy or bronchial asthma possible exacerbation or activation of systemic lupus erythematosus by thiazides has been reported the safe use of triamterene and hydrochlorothiazide tablets in pregnancy has not been established since there are no adequate and well-controlled studies with triamterene and hydrochlorothiazide tablets in pregnant women the use of thiazides and triamterene in pregnant women requires that the anticipated benefits be weighed against possible hazards to the fetus thiazides and triamterene have been shown to cross the placental barrier and appear in cord blood if use of the combination drug product is deemed essential, the patient should stop nursing safety and effectiveness in pediatric patients have not been established Pregnancy & Lactation the safe use of triamterene and hydrochlorothiazide tablets in pregnancy has not been established since there are no adequate and well-controlled studies with triamterene and hydrochlorothiazide tablets in pregnant women triamterene and hydrochlorothiazide tablets should be used during pregnancy only if the potential benefit justifies the risk to the fetus this drug should be used during pregnancy only if clearly needed the use of thiazides and triamterene in pregnant women requires that the anticipated benefits be weighed against possible hazards to the fetus these hazards include fetal or neonatal jaundice, pancreatitis, thrombocytopenia, and possibly other adverse reactions that have occurred in the adult if use of the combination drug product is deemed essential, the patient should stop nursing Side Effects jaundice (intrahepatic cholestatic jaundice) pancreatitis nausea appetite disturbance taste alteration vomiting diarrhea constipation anorexia gastric irritation cramping drowsiness and fatigue insomnia headache dizziness dry mouth depression anxiety vertigo restlessness paresthesias tachycardia shortness of breath and chest pain orthostatic hypotension (may be aggravated by alcohol, barbiturates or narcotics) acute renal failure acute interstitial nephritis renal stones composed of triamterene in association with other calculus materials urine discoloration leukopenia agranulocytosis thrombocytopenia aplastic anemia hemolytic anemia and megaloblastosis xanthopsia transient blurred vision anaphylaxis photosensitivity rash urticaria purpura necrotizing angiitis (vasculitis, cutaneous vasculitis) fever respiratory distress including pneumonitis muscle cramps and weakness decreased sexual performance sialadenitis hyperkalemia hypokalemia hyponatremia hypomagnesemia hypochloremia hyperglycemia glycosuria diabetes mellitus elevated liver enzymes acute transient myopia acute angle-closure glaucoma
Triamterene and Hydrochlorothiazide Rx tablet BluePoint Laboratories	Popularity – score 0 out of 100 (least-viewed drug)	26 warnings	5 pregnancy and lactation warnings	72 side effects	Trend: was flat over 11 months.
Triamterene and Hydrochlorothiazide® · First marketed 2017 · Label last revised September 30, 2025View full label details → Warnings You may experience an abnormal elevation of serum potassium levels with all potassium-conserving diuretic combinations. Hyperkalemia is more likely to occur if you have renal impairment, diabetes, or if you are elderly or severely ill. Your healthcare provider must monitor serum potassium levels at frequent intervals, especially when you first start taking triamterene and hydrochlorothiazide. If you suspect hyperkalemia, an electrocardiogram (ECG) should be obtained. If hyperkalemia is confirmed, you should stop taking triamterene and hydrochlorothiazide immediately. If you have mild renal functional impairment, you should not receive this drug without frequent and ongoing monitoring of your serum electrolytes. You should avoid triamterene and hydrochlorothiazide if you have diabetes. If you do use this medication, your serum electrolytes must be monitored frequently. Use triamterene and hydrochlorothiazide cautiously, if at all, with angiotensin-converting enzyme (ACE) inhibitors. Potassium-conserving therapy should also be avoided if you are severely ill and at risk for respiratory or metabolic acidosis. Frequent evaluations of your acid/base balance and serum electrolytes are necessary if you are taking triamterene and hydrochlorothiazide. Hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma. Untreated acute angle-closure glaucoma can lead to permanent vision loss. You should use triamterene and hydrochlorothiazide with caution if you have impaired hepatic function or progressive liver disease. Minor alterations in fluid and electrolyte balance may precipitate hepatic coma. Use triamterene and hydrochlorothiazide with caution if you have a history of renal lithiasis. Triamterene is a weak folic acid antagonist and may contribute to the appearance of megaloblastosis if your folic acid stores are decreased. Hyperuricemia may occur, or acute gout may be triggered in certain patients receiving thiazide therapy. Sensitivity reactions to thiazides may occur in patients with or without a history of allergy or bronchial asthma. There have been reports of possible exacerbation or activation of systemic lupus erythematosus by thiazides. The safe use of triamterene and hydrochlorothiazide during pregnancy has not been established. You should weigh the anticipated benefits of thiazides and triamterene against possible hazards to the fetus if you are pregnant. Thiazides and triamterene can cross the placental barrier and appear in cord blood. If the use of this combination drug is deemed essential, you should stop nursing. Safety and effectiveness in pediatric patients have not been established. If you are taking hydrochlorothiazide, be sure to protect your skin from the sun and undergo regular skin cancer screenings. Pregnancy & Lactation If you find that using this combination drug is essential, you should stop nursing. The safe use of triamterene and hydrochlorothiazide during pregnancy has not been established, as there are no adequate and well-controlled studies involving pregnant women. You should use triamterene and hydrochlorothiazide during pregnancy only if the potential benefits outweigh the risks to your fetus. This drug should be used during pregnancy only if it is clearly necessary. If you are pregnant, the use of thiazides and triamterene requires careful consideration of the anticipated benefits against possible risks to your fetus. Side Effects jaundice (intrahepatic cholestatic jaundice) pancreatitis nausea changes in appetite altered taste vomiting diarrhea constipation anorexia gastric irritation cramping drowsiness and fatigue insomnia headache dizziness dry mouth depression anxiety vertigo restlessness tingling sensations rapid heartbeat shortness of breath and chest pain orthostatic hypotension (this may be worsened by alcohol, barbiturates, or narcotics) acute renal failure acute interstitial nephritis renal stones made of triamterene along with other materials urine discoloration leukopenia agranulocytosis thrombocytopenia aplastic anemia hemolytic anemia megaloblastosis xanthopsia temporary blurred vision anaphylaxis photosensitivity rash hives purpura necrotizing angiitis (vasculitis, cutaneous vasculitis) fever respiratory distress including pneumonitis muscle cramps and weakness decreased sexual performance sialadenitis high potassium levels (hyperkalemia) low potassium levels (hypokalemia) low sodium levels (hyponatremia) low magnesium levels (hypomagnesemia) low chloride levels (hypochloremia) high blood sugar (hyperglycemia) sugar in urine (glycosuria) diabetes mellitus elevated liver enzymes acute transient myopia acute angle-closure glaucoma dry mouth thirst weakness lethargy drowsiness restlessness muscle pains or cramps muscle fatigue low blood pressure (hypotension) reduced urine output (oliguria) rapid heartbeat (tachycardia) gastrointestinal disturbances such as nausea and vomiting high uric acid levels (hyperuricemia) acute gout Warnings abnormal elevation of serum potassium levels can occur with all potassium-conserving diuretic combinations hyperkalemia is more likely to occur in patients with renal impairment, diabetes, or elderly or severely ill patients serum potassium levels must be monitored at frequent intervals especially in patients first receiving triamterene and hydrochlorothiazide if hyperkalemia is suspected, an electrocardiogram (ECG) should be obtained if hyperkalemia is present, triamterene and hydrochlorothiazide should be discontinued immediately patients with mild renal functional impairment should not receive this drug without frequent and continuing monitoring of serum electrolytes triamterene and hydrochlorothiazide should be avoided in diabetic patients if it is employed, serum electrolytes must be frequently monitored triamterene and hydrochlorothiazide should be used cautiously, if at all, with angiotensin-converting enzyme (ACE) inhibitors potassium-conserving therapy should also be avoided in severely ill patients in whom respiratory or metabolic acidosis may occur frequent evaluations of acid/base balance and serum electrolytes are necessary if triamterene and hydrochlorothiazide is employed hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma untreated acute angle-closure glaucoma can lead to permanent vision loss triamterene and hydrochlorothiazide should be used with caution in patients with impaired hepatic function or progressive liver disease minor alterations of fluid and electrolyte balance may precipitate hepatic coma triamterene and hydrochlorothiazide should be used with caution in patients with histories of renal lithiasis triamterene is a weak folic acid antagonist and may contribute to the appearance of megaloblastosis in instances where folic acid stores are decreased hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazide therapy sensitivity reactions to thiazides may occur in patients with or without a history of allergy or bronchial asthma possible exacerbation or activation of systemic lupus erythematosus by thiazides has been reported the safe use of triamterene and hydrochlorothiazide in pregnancy has not been established the anticipated benefits of thiazides and triamterene in pregnant women should be weighed against possible hazards to the fetus thiazides and triamterene have been shown to cross the placental barrier and appear in cord blood if use of the combination drug product is deemed essential, the patient should stop nursing safety and effectiveness in pediatric patients have not been established instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening Pregnancy & Lactation if use of the combination drug product is deemed essential, the patient should stop nursing the safe use of triamterene and hydrochlorothiazide in pregnancy has not been established since there are no adequate and well controlled studies with triamterene and hydrochlorothiazide in pregnant women triamterene and hydrochlorothiazide should be used during pregnancy only if the potential benefit justifies the risk to the fetus this drug should be used during pregnancy only if clearly needed the use of thiazides and triamterene in pregnant women requires that the anticipated benefits be weighed against possible hazards to the fetus Side Effects jaundice (intrahepatic cholestatic jaundice) pancreatitis nausea appetite disturbance taste alteration vomiting diarrhea constipation anorexia gastric irritation cramping drowsiness and fatigue insomnia headache dizziness dry mouth depression anxiety vertigo restlessness paresthesias tachycardia shortness of breath and chest pain orthostatic hypotension (may be aggravated by alcohol, barbiturates or narcotics) acute renal failure acute interstitial nephritis renal stones composed of triamterene in association with other calculus materials urine discoloration leukopenia agranulocytosis thrombocytopenia aplastic anemia hemolytic anemia megaloblastosis xanthopsia transient blurred vision anaphylaxis photosensitivity rash urticaria purpura necrotizing angiitis (vasculitis, cutaneous vasculitis) fever respiratory distress including pneumonitis muscle cramps and weakness decreased sexual performance sialadenitis hyperkalemia hypokalemia hyponatremia hypomagnesemia hypochloremia hyperglycemia glycosuria diabetes mellitus elevated liver enzymes acute transient myopia acute angle-closure glaucoma dryness of mouth thirst weakness lethargy drowsiness restlessness muscle pains or cramps muscular fatigue hypotension oliguria tachycardia gastrointestinal disturbances such as nausea and vomiting hyperuricemia acute gout
Triamterene and Hydrochlorothiazide Rx tablet REMEDYREPACK INC.	Popularity – score 0 out of 100 (least-viewed drug)	21 warnings	3 pregnancy and lactation warnings	58 side effects	Trend: was flat over 11 months.
Triamterene and Hydrochlorothiazide® · First marketed 2025 · Label last revised June 2, 2025View full label details → Warnings You may experience an abnormal elevation of serum potassium levels with all potassium-conserving diuretic combinations. Hyperkalemia is more likely to occur if you have renal impairment, diabetes, or if you are elderly or severely ill. Your healthcare provider must monitor serum potassium levels at frequent intervals, especially when you first start taking triamterene and hydrochlorothiazide. If you suspect hyperkalemia, an electrocardiogram (ECG) should be obtained. If hyperkalemia is confirmed, you should stop taking triamterene and hydrochlorothiazide immediately. If you have mild renal functional impairment, you should not take this drug without frequent and ongoing monitoring of your serum electrolytes. You should avoid triamterene and hydrochlorothiazide if you have diabetes. If you do use this medication, your serum electrolytes must be monitored frequently. Potassium-sparing therapy should also be avoided if you are severely ill and at risk for respiratory or metabolic acidosis. Frequent evaluations of your acid/base balance and serum electrolytes are necessary if you are taking triamterene and hydrochlorothiazide. Hydrochlorothiazide can cause an idiosyncratic reaction, leading to acute transient myopia and acute angle-closure glaucoma. Untreated acute angle-closure glaucoma can result in permanent vision loss. You should use triamterene and hydrochlorothiazide with caution if you have impaired hepatic function or progressive liver disease. Use triamterene and hydrochlorothiazide with caution if you have a history of renal lithiasis. Triamterene is a weak folic acid antagonist and may contribute to the appearance of megaloblastosis if your folic acid stores are low. Hyperuricemia may occur, or acute gout may be triggered in certain patients receiving thiazide therapy. Sensitivity reactions to thiazides may occur, even if you do not have a history of allergy or bronchial asthma. If you are pregnant, the use of thiazides and triamterene requires careful consideration of the benefits versus potential risks to your fetus. If the combination drug is deemed essential, you should stop nursing. Safety and effectiveness in children have not been established. If you are taking hydrochlorothiazide, be sure to protect your skin from the sun and undergo regular skin cancer screenings. Pregnancy & Lactation Triamterene may be present in animal milk, and this could also happen in humans. Thiazides can be found in human breast milk. If your healthcare provider determines that using the combination drug is necessary, you should stop nursing. Side Effects jaundice (intrahepatic cholestatic jaundice) pancreatitis nausea changes in appetite altered taste vomiting diarrhea constipation loss of appetite gastric irritation cramping drowsiness and fatigue insomnia headache dizziness dry mouth depression anxiety vertigo restlessness tingling sensations rapid heartbeat shortness of breath and chest pain orthostatic hypotension (this may be worsened by alcohol, barbiturates, or narcotics) acute renal failure acute interstitial nephritis renal stones made of triamterene along with other materials urine discoloration leukopenia agranulocytosis thrombocytopenia aplastic anemia hemolytic anemia megaloblastosis xanthopsia temporary blurred vision anaphylaxis photosensitivity rash hives purpura necrotizing angiitis (vasculitis, cutaneous vasculitis) fever respiratory distress including pneumonitis muscle cramps and weakness decreased sexual performance sialadenitis high potassium levels (hyperkalemia) low potassium levels (hypokalemia) low sodium levels (hyponatremia) low magnesium levels (hypomagnesemia) low chloride levels (hypochloremia) high blood sugar (hyperglycemia) sugar in urine (glycosuria) diabetes mellitus elevated liver enzymes acute transient myopia acute angle-closure glaucoma Warnings abnormal elevation of serum potassium levels can occur with all potassium-conserving diuretic combinations hyperkalemia is more likely to occur in patients with renal impairment, diabetes, or elderly or severely ill patients serum potassium levels must be monitored at frequent intervals especially in patients first receiving triamterene and hydrochlorothiazide if hyperkalemia is suspected, an electrocardiogram (ECG) should be obtained if hyperkalemia is present, triamterene and hydrochlorothiazide should be discontinued immediately patients with mild renal functional impairment should not receive this drug without frequent and continuing monitoring of serum electrolytes triamterene and hydrochlorothiazide should be avoided in diabetic patients if it is employed, serum electrolytes must be frequently monitored potassium-sparing therapy should also be avoided in severely ill patients in whom respiratory or metabolic acidosis may occur frequent evaluations of acid/base balance and serum electrolytes are necessary if triamterene and hydrochlorothiazide is employed hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma untreated acute angle-closure glaucoma can lead to permanent vision loss triamterene and hydrochlorothiazide should be used with caution in patients with impaired hepatic function or progressive liver disease triamterene and hydrochlorothiazide should be used with caution in patients with histories of renal lithiasis triamterene is a weak folic acid antagonist and may contribute to the appearance of megaloblastosis in instances where folic acid stores are decreased hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazide therapy sensitivity reactions to thiazides may occur in patients with or without a history of allergy or bronchial asthma the use of thiazides and triamterene in pregnant women requires that the anticipated benefits be weighed against possible hazards to the fetus if use of the combination drug product is deemed essential, the patient should stop nursing safety and effectiveness in pediatric patients have not been established instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening Pregnancy & Lactation triamterene appears in animal milk and this may occur in humans thiazides are excreted in human breast milk if use of the combination drug product is deemed essential, the patient should stop nursing Side Effects jaundice (intrahepatic cholestatic jaundice) pancreatitis nausea appetite disturbance taste alteration vomiting diarrhea constipation anorexia gastric irritation cramping drowsiness and fatigue insomnia headache dizziness dry mouth depression anxiety vertigo restlessness paresthesias tachycardia shortness of breath and chest pain orthostatic hypotension (may be aggravated by alcohol, barbiturates or narcotics) acute renal failure acute interstitial nephritis renal stones composed of triamterene in association with other calculus materials urine discoloration leukopenia agranulocytosis thrombocytopenia aplastic anemia hemolytic anemia megaloblastosis xanthopsia transient blurred vision anaphylaxis photosensitivity rash urticaria purpura necrotizing angiitis (vasculitis, cutaneous vasculitis) fever respiratory distress including pneumonitis muscle cramps and weakness decreased sexual performance sialadenitis hyperkalemia hypokalemia hyponatremia hypomagnesemia hypochloremia hyperglycemia glycosuria diabetes mellitus elevated liver enzymes acute transient myopia acute angle-closure glaucoma
Triamterene and Hydrochlorothiazide Rx capsule REMEDYREPACK INC.	Popularity – score 0 out of 100 (least-viewed drug)	20 warnings	6 pregnancy and lactation warnings	54 side effects	Trend: was flat over 11 months.
Triamterene and Hydrochlorothiazide® · First marketed 2025 · Label last revised October 1, 2025View full label details → Warnings You may experience an abnormal elevation of serum potassium levels with all potassium-sparing diuretic combinations. Hyperkalemia is more likely to occur if you have renal impairment or diabetes. Your healthcare provider should monitor your serum potassium levels at frequent intervals, especially when you first start taking triamterene and hydrochlorothiazide capsules. Exercise caution when taking triamterene and hydrochlorothiazide capsules if you have diabetes. Thiazides should be used carefully if you have impaired hepatic function. Thiazides can trigger hepatic coma in individuals with severe liver disease. Administer triamterene and hydrochlorothiazide capsules cautiously, and be alert for early signs of impending coma, such as confusion, drowsiness, and tremor. If you notice an increase in mental confusion, you should stop taking triamterene and hydrochlorothiazide capsules for a few days. If serious hypokalemia is confirmed by repeat serum potassium tests, you should discontinue triamterene and hydrochlorothiazide capsules. For less serious hypokalemia, your healthcare provider will evaluate other coexisting conditions and treat them accordingly. Be aware that diuretics may worsen electrolyte imbalance, which should be considered during your therapy with triamterene and hydrochlorothiazide. Your healthcare provider should perform serum determinations of electrolytes, especially if you are vomiting excessively or receiving fluids parenterally. Watch for warning signs of possible fluid and electrolyte imbalance, such as dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pain or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal symptoms. Use triamterene and hydrochlorothiazide capsules with caution if you have a history of renal stones. If you are taking hydrochlorothiazide, be sure to protect your skin from the sun and undergo regular skin cancer screenings. The safe use of triamterene and hydrochlorothiazide capsules during pregnancy has not been established. You should use triamterene and hydrochlorothiazide capsules during pregnancy only if the potential benefit justifies the risk to your fetus. When considering the use of thiazides and triamterene in pregnant women, weigh the anticipated benefit against possible hazards to the fetus. If the use of this combination drug is deemed essential, you should stop nursing. The safety and effectiveness of triamterene and hydrochlorothiazide capsules in pediatric patients have not been established. Pregnancy & Lactation The safe use of triamterene and hydrochlorothiazide capsules during pregnancy has not been established, as there are no adequate and well-controlled studies involving pregnant women. You should use triamterene and hydrochlorothiazide capsules during pregnancy only if the potential benefits outweigh the risks to your fetus. This medication should be used during pregnancy only if it is clearly necessary. When considering the use of thiazides and triamterene in pregnant women, it's important to weigh the anticipated benefits against possible risks to the fetus. These risks may include fetal or neonatal jaundice, pancreatitis, thrombocytopenia, and other adverse reactions that have been observed in adults. If the use of this combination drug is deemed essential, you should stop nursing. Side Effects You may experience anaphylaxis. You might develop a rash. Urticaria could occur. There may be subacute cutaneous lupus erythematosus-like reactions. Photosensitivity is a possible side effect. You could experience arrhythmia. Postural hypotension may happen. You might develop diabetes mellitus. Hyperkalemia is a potential concern. Hypokalemia could occur. You may experience hyponatremia. Acidosis is a possible side effect. Hypercalcemia may occur. You might experience hyperglycemia. Glycosuria could happen. Hyperuricemia is a potential concern. Hypochloremia may occur. You might experience jaundice and/or liver enzyme abnormalities. Pancreatitis is a possible side effect. Nausea and vomiting may occur. You could experience diarrhea. Constipation is a potential concern. You might have abdominal pain. Acute renal failure has been reported in one case, with irreversible renal failure. Interstitial nephritis could occur. You may develop renal stones composed primarily of triamterene. Elevated BUN and serum creatinine are possible. Abnormal urinary sediment may occur. You might experience leukopenia. Thrombocytopenia and purpura could happen. Megaloblastic anemia is a potential concern. You may experience muscle cramps. Weakness could occur. Fatigue is a possible side effect. You might feel dizziness. Headaches may occur. You could experience dry mouth. Impotence is a potential concern. Sialadenitis may occur. Paresthesias could happen. You might experience vertigo. Xanthopsia is a possible side effect. Transient blurred vision may occur. You could experience allergic pneumonitis. Pulmonary edema is a potential concern. Respiratory distress may occur. Necrotizing vasculitis could happen. Exacerbation of lupus is a possible side effect. Aplastic anemia may occur. Agranulocytosis is a potential concern. Hemolytic anemia could happen. Thrombocytopenia and pancreatitis may rarely occur in newborns whose mothers received thiazides during pregnancy. Erythema multiforme, including Stevens-Johnson syndrome, is a possible side effect. Exfoliative dermatitis, including toxic epidermal necrolysis, may occur. Warnings abnormal elevation of serum potassium levels can occur with all potassium-sparing diuretic combinations hyperkalemia is more likely to occur in patients with renal impairment and diabetes serum potassium levels must be monitored at frequent intervals especially in patients first receiving triamterene and hydrochlorothiazide capsules caution should be exercised when administering triamterene and hydrochlorothiazide capsules to patients with diabetes thiazides should be used with caution in patients with impaired hepatic function thiazides can precipitate hepatic coma in patients with severe liver disease administer triamterene and hydrochlorothiazide capsules cautiously and be alert for early signs of impending coma such as confusion, drowsiness, and tremor if mental confusion increases, discontinue triamterene and hydrochlorothiazide capsules for a few days if serious hypokalemia is demonstrated by repeat serum potassium determinations, triamterene and hydrochlorothiazide capsules should be discontinued less serious hypokalemia should be evaluated with regard to other coexisting conditions and treated accordingly electrolyte imbalance may also be aggravated by diuretics and should be considered during therapy with triamterene and hydrochlorothiazide serum determinations of electrolytes should be performed and are particularly important if the patient is vomiting excessively or receiving fluids parenterally possible fluid and electrolyte imbalance may be indicated by warning signs such as dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pain or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal symptoms triamterene and hydrochlorothiazide capsules should be used with caution in patients with a history of renal stones instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening the safe use of triamterene and hydrochlorothiazide capsules in pregnancy has not been established triamterene and hydrochlorothiazide capsules should be used during pregnancy only if the potential benefit justifies the risk to the fetus the use of thiazides and triamterene in pregnant women requires that the anticipated benefit be weighed against possible hazards to the fetus if use of the combination drug product is deemed essential, the patient should stop nursing safety and effectiveness in pediatric patients have not been established Pregnancy & Lactation the safe use of triamterene and hydrochlorothiazide capsules in pregnancy has not been established since there are no adequate and well-controlled studies with triamterene and hydrochlorothiazide in pregnant women triamterene and hydrochlorothiazide capsules should be used during pregnancy only if the potential benefit justifies the risk to the fetus this drug should be used during pregnancy only if clearly needed the use of thiazides and triamterene in pregnant women requires that the anticipated benefit be weighed against possible hazards to the fetus these hazards include fetal or neonatal jaundice, pancreatitis, thrombocytopenia, and possible other adverse reactions which have occurred in the adult if use of the combination drug product is deemed essential, the patient should stop nursing Side Effects anaphylaxis rash urticaria subacute cutaneous lupus erythematosus-like reactions photosensitivity arrhythmia postural hypotension diabetes mellitus hyperkalemia hypokalemia hyponatremia acidosis hypercalcemia hyperglycemia glycosuria hyperuricemia hypochloremia jaundice and/or liver enzyme abnormalities pancreatitis nausea and vomiting diarrhea constipation abdominal pain acute renal failure (one case of irreversible renal failure has been reported) interstitial nephritis renal stones composed primarily of triamterene elevated BUN and serum creatinine abnormal urinary sediment leukopenia thrombocytopenia and purpura megaloblastic anemia muscle cramps weakness fatigue dizziness headache dry mouth impotence sialadenitis paresthesias vertigo xanthopsia transient blurred vision allergic pneumonitis pulmonary edema respiratory distress necrotizing vasculitis exacerbation of lupus aplastic anemia agranulocytosis hemolytic anemia thrombocytopenia and pancreatitis–rarely, in newborns whose mothers have received thiazides during pregnancy erythema multiforme, including Stevens-Johnson syndrome exfoliative dermatitis, including toxic epidermal necrolysis
Triamterene and Hydrochlorothiazide Rx capsule Viona Pharmaceuticals Inc	Popularity – score 0 out of 100 (least-viewed drug)	24 warnings	6 pregnancy and lactation warnings	54 side effects	Trend: was flat over 11 months.
Triamterene and Hydrochlorothiazide® · First marketed 2020 · Label last revised October 31, 2023View full label details → Warnings You may experience an abnormal elevation of serum potassium levels with all potassium-sparing diuretic combinations, including triamterene and hydrochlorothiazide capsules. Hyperkalemia is more likely to occur in individuals with renal impairment, diabetes, the elderly, or those who are severely ill. Your healthcare provider must monitor serum potassium levels at frequent intervals, especially when you first start taking triamterene and hydrochlorothiazide capsules, when your dosages change, or if you have any illness that may affect your renal function. Exercise caution when taking triamterene and hydrochlorothiazide capsules if you have diabetes, as thiazides may cause hyperglycemia, glycosuria, and alter your insulin requirements. Diabetes mellitus may become apparent during thiazide administration. Use thiazides with caution if you have impaired hepatic function. They can precipitate hepatic coma in individuals with severe liver disease. Administer triamterene and hydrochlorothiazide capsules cautiously and be alert for early signs of impending coma, such as confusion, drowsiness, and tremor. If you notice an increase in mental confusion, discontinue triamterene and hydrochlorothiazide capsules for a few days. Pay attention to other factors that may trigger hepatic coma, such as blood in the gastrointestinal tract or pre-existing potassium depletion. If serious hypokalemia is confirmed by repeat serum potassium tests, you should discontinue triamterene and hydrochlorothiazide capsules and start potassium chloride supplementation. Less serious hypokalemia should be evaluated in light of other coexisting conditions and treated accordingly. Serum determinations of electrolytes should be performed, especially if you are vomiting excessively or receiving fluids parenterally. Possible fluid and electrolyte imbalance may be indicated by warning signs such as dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pain or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal symptoms. Use triamterene and hydrochlorothiazide capsules with caution if you have a history of renal stones. Potassium-sparing agents should be used cautiously with angiotensin-converting enzyme inhibitors due to an increased risk of hyperkalemia. Concurrent use with chlorpropamide may increase the risk of severe hyponatremia. Exercise caution when administering nonsteroidal anti-inflammatory agents with triamterene and hydrochlorothiazide capsules. Lithium generally should not be taken with diuretics, as they reduce its renal clearance and increase the risk of lithium toxicity. Caution should be observed if you are undergoing surgery. If you are pregnant, the use of thiazides and triamterene requires weighing the anticipated benefits against possible hazards to the fetus. These hazards may include fetal or neonatal jaundice, pancreatitis, thrombocytopenia, and other adverse reactions that have occurred in adults. If the use of the combination drug product is deemed essential, you should stop nursing. Safety and effectiveness in pediatric patients have not been established. Pregnancy & Lactation The safe use of triamterene and hydrochlorothiazide capsules during pregnancy has not been established, as there are no adequate and well-controlled studies involving pregnant women. You should use triamterene and hydrochlorothiazide capsules during pregnancy only if the potential benefits outweigh the risks to your fetus. This medication should only be used during pregnancy if it is clearly necessary. When considering the use of thiazides and triamterene in pregnant women, it is important to weigh the anticipated benefits against possible risks to the fetus. These risks may include fetal or neonatal jaundice, pancreatitis, thrombocytopenia, and other adverse reactions that have been observed in adults. If the use of this combination drug is considered essential, you should stop nursing. Side Effects You may experience anaphylaxis. You might notice a rash. Urticaria could occur. There may be subacute cutaneous lupus erythematosus-like reactions. Photosensitivity is a possible side effect. You could experience arrhythmia. Postural hypotension may happen. You might develop diabetes mellitus. Hyperkalemia is a potential concern. Hypokalemia could occur. You may experience hyponatremia. Acidosis is a possible side effect. Hypercalcemia may occur. You might experience hyperglycemia. Glycosuria could happen. Hyperuricemia is a potential concern. Hypochloremia may occur. You might experience jaundice and/or liver enzyme abnormalities. Pancreatitis is a possible side effect. Nausea and vomiting may occur. You could experience diarrhea. Constipation is a potential concern. You might have abdominal pain. Acute renal failure has been reported in one case, including irreversible renal failure. Interstitial nephritis may occur. You could develop renal stones composed primarily of triamterene. Elevated BUN and serum creatinine may be observed. Abnormal urinary sediment could occur. You might experience leukopenia. Thrombocytopenia and purpura may happen. Megaloblastic anemia is a potential concern. You might experience muscle cramps. Weakness could occur. Fatigue is a possible side effect. You may feel dizziness. Headaches could occur. You might experience dry mouth. Impotence is a potential concern. Sialadenitis may occur. Paresthesias could happen. You might experience vertigo. Xanthopsia is a possible side effect. Transient blurred vision may occur. You could experience allergic pneumonitis. Pulmonary edema is a potential concern. You might experience respiratory distress. Necrotizing vasculitis may occur. Exacerbation of lupus is a possible side effect. Aplastic anemia could happen. Agranulocytosis is a potential concern. Hemolytic anemia may occur. Thrombocytopenia and pancreatitis have rarely been reported in newborns whose mothers received thiazides during pregnancy. Erythema multiforme, including Stevens-Johnson syndrome, is a possible side effect. Exfoliative dermatitis, including toxic epidermal necrolysis, may occur. Warnings abnormal elevation of serum potassium levels can occur with all potassium-sparing diuretic combinations, including triamterene and hydrochlorothiazide capsules hyperkalemia is more likely to occur in patients with renal impairment and diabetes and in the elderly or severely ill serum potassium levels must be monitored at frequent intervals especially in patients first receiving triamterene and hydrochlorothiazide capsules, when dosages are changed, or with any illness that may influence renal function caution should be exercised when administering triamterene and hydrochlorothiazide capsules to patients with diabetes, since thiazides may cause hyperglycemia, glycosuria, and alter insulin requirements in diabetes diabetes mellitus may become manifest during thiazide administration thiazides should be used with caution in patients with impaired hepatic function they can precipitate hepatic coma in patients with severe liver disease administer triamterene and hydrochlorothiazide capsules cautiously and be alert for early signs of impending coma such as confusion, drowsiness, and tremor if mental confusion increases, discontinue triamterene and hydrochlorothiazide capsules for a few days attention must be given to other factors that may precipitate hepatic coma, such as blood in the gastrointestinal tract or pre-existing potassium depletion if serious hypokalemia is demonstrated by repeat serum potassium determinations, triamterene and hydrochlorothiazide capsules should be discontinued and potassium chloride supplementation initiated less serious hypokalemia should be evaluated with regard to other coexisting conditions and treated accordingly serum determinations of electrolytes should be performed and are particularly important if the patient is vomiting excessively or receiving fluids parenterally possible fluid and electrolyte imbalance may be indicated by warning signs such as: dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pain or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal symptoms triamterene and hydrochlorothiazide capsules should be used with caution in patients with a history of renal stones potassium-sparing agents should be used with caution in conjunction with angiotensin-converting enzyme inhibitors due to an increased risk of hyperkalemia concurrent use with chlorpropamide may increase the risk of severe hyponatremia caution is advised in administering nonsteroidal anti-inflammatory agents with triamterene and hydrochlorothiazide capsules lithium generally should not be given with diuretics because they reduce its renal clearance and increase the risk of lithium toxicity caution should be observed in patients undergoing surgery the use of thiazides and triamterene in pregnant women requires that the anticipated benefit be weighed against possible hazards to the fetus these hazards include fetal or neonatal jaundice, pancreatitis, thrombocytopenia, and possible other adverse reactions which have occurred in the adult if use of the combination drug product is deemed essential, the patient should stop nursing safety and effectiveness in pediatric patients have not been established Pregnancy & Lactation the safe use of triamterene and hydrochlorothiazide capsules in pregnancy has not been established since there are no adequate and well-controlled studies with triamterene and hydrochlorothiazide in pregnant women triamterene and hydrochlorothiazide capsules should be used during pregnancy only if the potential benefit justifies the risk to the fetus this drug should be used during pregnancy only if clearly needed the use of thiazides and triamterene in pregnant women requires that the anticipated benefit be weighed against possible hazards to the fetus these hazards include fetal or neonatal jaundice, pancreatitis, thrombocytopenia, and possible other adverse reactions which have occurred in the adult if use of the combination drug product is deemed essential, the patient should stop nursing Side Effects anaphylaxis rash urticaria subacute cutaneous lupus erythematosus-like reactions photosensitivity arrhythmia postural hypotension diabetes mellitus hyperkalemia hypokalemia hyponatremia acidosis hypercalcemia hyperglycemia glycosuria hyperuricemia hypochloremia jaundice and/or liver enzyme abnormalities pancreatitis nausea and vomiting diarrhea constipation abdominal pain acute renal failure (one case of irreversible renal failure has been reported) interstitial nephritis renal stones composed primarily of triamterene elevated BUN and serum creatinine abnormal urinary sediment leukopenia thrombocytopenia and purpura megaloblastic anemia muscle cramps weakness fatigue dizziness headache dry mouth impotence sialadenitis paresthesias vertigo xanthopsia transient blurred vision allergic pneumonitis pulmonary edema respiratory distress necrotizing vasculitis exacerbation of lupus aplastic anemia agranulocytosis hemolytic anemia thrombocytopenia and pancreatitis–rarely, in newborns whose mothers have received thiazides during pregnancy erythema multiforme, including Stevens-Johnson syndrome exfoliative dermatitis, including toxic epidermal necrolysis
Triamterene and Hydrochlorothiazide Rx tablet Advagen Pharma Ltd	Popularity – score 0 out of 100 (least-viewed drug)	27 warnings	3 pregnancy and lactation warnings	57 side effects	Trend: was flat over 11 months.
Triamterene and Hydrochlorothiazide® · First marketed 2022 · Label last revised January 7, 2026View full label details → Warnings You may experience an abnormal elevation of serum potassium levels with all potassium-conserving diuretic combinations, including triamterene and hydrochlorothiazide. Hyperkalemia is more likely to occur if you have renal impairment, diabetes, or if you are elderly or severely ill. Your healthcare provider must monitor serum potassium levels at frequent intervals, especially when you first start taking triamterene and hydrochlorothiazide, when your dosages change, or if you have any illness that may affect renal function. If you suspect hyperkalemia, an electrocardiogram (ECG) should be obtained. If hyperkalemia is confirmed, you should stop taking triamterene and hydrochlorothiazide immediately, and a thiazide alone should be substituted. If you have mild renal functional impairment, you should not take this drug without frequent and ongoing monitoring of your serum electrolytes. Cumulative drug effects may occur if you have impaired renal function. You should avoid triamterene and hydrochlorothiazide if you have diabetes. If you do take it, your serum electrolytes must be monitored frequently. Potassium-sparing therapy should also be avoided if you are severely ill and at risk for respiratory or metabolic acidosis. Frequent evaluations of acid/base balance and serum electrolytes are necessary if you are using triamterene and hydrochlorothiazide. Hydrochlorothiazide can cause an idiosyncratic reaction, leading to acute transient myopia and acute angle-closure glaucoma. Symptoms may include a sudden decrease in visual acuity or ocular pain, typically occurring within hours to weeks after starting the drug. If left untreated, acute angle-closure glaucoma can result in permanent vision loss. You should use triamterene and hydrochlorothiazide with caution if you have impaired hepatic function or progressive liver disease. Use triamterene and hydrochlorothiazide with caution if you have a history of renal lithiasis. Triamterene is a weak folic acid antagonist and may contribute to the appearance of megaloblastosis if your folic acid stores are low. Hyperuricemia may occur, or acute gout may be triggered in certain patients receiving thiazide therapy. Sensitivity reactions to thiazides may happen, even if you do not have a history of allergy or bronchial asthma. There have been reports of possible exacerbation or activation of systemic lupus erythematosus by thiazides. The safe use of triamterene and hydrochlorothiazide during pregnancy has not been established, as there are no adequate and well-controlled studies in pregnant women. You should use triamterene and hydrochlorothiazide during pregnancy only if the potential benefit outweighs the risk to the fetus. When considering the use of thiazides and triamterene in pregnant women, the anticipated benefits must be weighed against possible risks to the fetus. The combination of thiazides and triamterene has not been studied in nursing mothers. If the use of this combination drug is deemed essential, you should stop nursing. Safety and effectiveness in pediatric patients have not been established. If you are taking hydrochlorothiazide, be sure to protect your skin from the sun and undergo regular skin cancer screenings. Pregnancy & Lactation Triamterene may be present in animal milk, and this could also happen in humans. Thiazides can be found in human breast milk. If your healthcare provider determines that using the combination drug product is necessary, you should stop nursing. Side Effects jaundice (intrahepatic cholestatic jaundice) pancreatitis nausea changes in appetite altered taste vomiting diarrhea constipation anorexia gastric irritation cramping drowsiness and fatigue insomnia headache dizziness dry mouth depression anxiety vertigo restlessness tingling sensations rapid heartbeat shortness of breath and chest pain orthostatic hypotension (this may be worsened by alcohol, barbiturates, or narcotics) acute renal failure acute interstitial nephritis renal stones made of triamterene along with other materials urine discoloration leukopenia agranulocytosis thrombocytopenia aplastic anemia hemolytic anemia and megaloblastosis xanthopsia temporary blurred vision anaphylaxis photosensitivity rash hives purpura necrotizing angiitis (vasculitis, cutaneous vasculitis) fever respiratory distress including pneumonitis muscle cramps and weakness decreased sexual performance sialadenitis high potassium levels (hyperkalemia) low potassium levels (hypokalemia) low sodium levels (hyponatremia) low magnesium levels (hypomagnesemia) low chloride levels (hypochloremia) high blood sugar (hyperglycemia) sugar in urine (glycosuria) diabetes mellitus elevated liver enzymes acute transient myopia acute angle-closure glaucoma Warnings abnormal elevation of serum potassium levels can occur with all potassium-conserving diuretic combinations, including triamterene and hydrochlorothiazide hyperkalemia is more likely to occur in patients with renal impairment, diabetes, or elderly or severely ill patients serum potassium levels must be monitored at frequent intervals especially in patients first receiving triamterene and hydrochlorothiazide, when dosages are changed or with any illness that may influence renal function if hyperkalemia is suspected, an electrocardiogram (ECG) should be obtained if hyperkalemia is present, triamterene and hydrochlorothiazide should be discontinued immediately and a thiazide alone should be substituted patients with mild renal functional impairment should not receive this drug without frequent and continuing monitoring of serum electrolytes cumulative drug effects may be observed in patients with impaired renal function triamterene and hydrochlorothiazide should be avoided in diabetic patients if it is employed, serum electrolytes must be frequently monitored potassium-sparing therapy should also be avoided in severely ill patients in whom respiratory or metabolic acidosis may occur frequent evaluations of acid/base balance and serum electrolytes are necessary if triamterene and hydrochlorothiazide is employed hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma symptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiation untreated acute angle-closure glaucoma can lead to permanent vision loss triamterene and hydrochlorothiazide should be used with caution in patients with impaired hepatic function or progressive liver disease triamterene and hydrochlorothiazide should be used with caution in patients with histories of renal lithiasis triamterene is a weak folic acid antagonist and may contribute to the appearance of megaloblastosis in instances where folic acid stores are decreased hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazide therapy sensitivity reactions to thiazides may occur in patients with or without a history of allergy or bronchial asthma possible exacerbation or activation of systemic lupus erythematosus by thiazides has been reported the safe use of triamterene and hydrochlorothiazide in pregnancy has not been established since there are no adequate and well controlled studies with triamterene and hydrochlorothiazide in pregnant women triamterene and hydrochlorothiazide should be used during pregnancy only if the potential benefit justifies the risk to the fetus the use of thiazides and triamterene in pregnant women requires that the anticipated benefits be weighed against possible hazards to the fetus thiazides and triamterene in combination have not been studied in nursing mothers if use of the combination drug product is deemed essential, the patient should stop nursing safety and effectiveness in pediatric patients have not been established instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening Pregnancy & Lactation triamterene appears in animal milk and this may occur in humans thiazides are excreted in human breast milk if use of the combination drug product is deemed essential, the patient should stop nursing Side Effects jaundice (intrahepatic cholestatic jaundice) pancreatitis nausea appetite disturbance taste alteration vomiting diarrhea constipation anorexia gastric irritation cramping drowsiness and fatigue insomnia headache dizziness dry mouth depression anxiety vertigo restlessness paresthesias tachycardia shortness of breath and chest pain orthostatic hypotension (may be aggravated by alcohol, barbiturates or narcotics) acute renal failure acute interstitial nephritis renal stones composed of triamterene in association with other calculus materials urine discoloration leukopenia agranulocytosis thrombocytopenia aplastic anemia hemolytic anemia and megaloblastosis xanthopsia transient blurred vision anaphylaxis photosensitivity rash urticaria purpura necrotizing angiitis (vasculitis, cutaneous vasculitis) fever respiratory distress including pneumonitis muscle cramps and weakness decreased sexual performance sialadenitis hyperkalemia hypokalemia hyponatremia hypomagnesemia hypochloremia hyperglycemia glycosuria diabetes mellitus elevated liver enzymes acute transient myopia acute angle-closure glaucoma
Triamterene and Hydrochlorothiazide Rx tablet Actavis Pharma, Inc.	Popularity – score 0 out of 100 (least-viewed drug)	30 warnings	6 pregnancy and lactation warnings	57 side effects	Trend: was flat over 11 months.
Triamterene and Hydrochlorothiazide® · First marketed 1993 · Label last revised May 1, 2024View full label details → Warnings Be aware that hyperkalemia, which is an abnormal elevation of serum potassium levels (greater than or equal to 5.5 mEq/liter), can occur with all potassium-conserving diuretic combinations, including triamterene and hydrochlorothiazide. You are at a higher risk for hyperkalemia if you have renal impairment, diabetes (even without evidence of renal impairment), or if you are elderly or severely ill. Your healthcare provider will need to monitor your serum potassium levels frequently, especially when you first start taking triamterene and hydrochlorothiazide, when your dosages change, or if you have any illness that may affect your renal function. If you suspect hyperkalemia (warning signs include paresthesias, muscular weakness, fatigue, flaccid paralysis of the extremities, bradycardia, and shock), an electrocardiogram (ECG) should be obtained promptly. If hyperkalemia is confirmed, you should stop taking triamterene and hydrochlorothiazide immediately, and a thiazide alone should be used instead. If you have mild renal functional impairment, you should not take this drug without frequent and ongoing monitoring of your serum electrolytes. Cumulative drug effects may occur if you have impaired renal function. You should avoid using triamterene and hydrochlorothiazide if you have diabetes. If you must use it, your serum electrolytes will need to be monitored frequently. Use triamterene and hydrochlorothiazide cautiously, if at all, with angiotensin-converting enzyme (ACE) inhibitors. Potassium-conserving therapy should also be avoided if you are severely ill and at risk for respiratory or metabolic acidosis. If you are prescribed triamterene and hydrochlorothiazide, your healthcare provider will need to frequently evaluate your acid/base balance and serum electrolytes. Hydrochlorothiazide can cause an idiosyncratic reaction, leading to acute transient myopia and acute angle-closure glaucoma. Symptoms may include a sudden decrease in visual acuity or ocular pain, typically occurring within hours to weeks after starting the medication. If left untreated, acute angle-closure glaucoma can result in permanent vision loss. The primary treatment is to discontinue hydrochlorothiazide as quickly as possible. Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. If you are taking triamterene and hydrochlorothiazide, your healthcare provider should carefully monitor you for fluid or electrolyte imbalances. Your healthcare provider will need to determine your serum electrolytes at appropriate intervals to check for possible imbalances. Warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting. Use triamterene and hydrochlorothiazide with caution if you have impaired hepatic function or progressive liver disease. Use triamterene and hydrochlorothiazide with caution if you have a history of renal lithiasis. Triamterene is a weak folic acid antagonist and may contribute to the appearance of megaloblastosis if your folic acid stores are low. Hyperuricemia may occur, or acute gout may be triggered in certain patients receiving thiazide therapy. Sensitivity reactions to thiazides may occur in patients with or without a history of allergy or bronchial asthma. There have been reports of possible exacerbation or activation of systemic lupus erythematosus by thiazides. The safe use of triamterene and hydrochlorothiazide tablets during pregnancy has not been established, as there are no adequate and well-controlled studies in pregnant women. If you are pregnant, the use of thiazides and triamterene requires weighing the anticipated benefits against possible risks to the fetus. If the combination drug is deemed essential, you should stop nursing. Safety and effectiveness in pediatric patients have not been established. Pregnancy & Lactation The safe use of triamterene and hydrochlorothiazide tablets during pregnancy has not been established, as there are no adequate and well-controlled studies involving pregnant women. You should use triamterene and hydrochlorothiazide tablets during pregnancy only if the potential benefits outweigh the risks to your fetus. This medication should only be used during pregnancy if it is clearly necessary. When considering the use of thiazides and triamterene in pregnant women, it's important to weigh the anticipated benefits against possible risks to the fetus. These risks may include fetal or neonatal jaundice, pancreatitis, thrombocytopenia, and potentially other adverse reactions that have been observed in adults. If the use of this combination drug is deemed essential, you should stop nursing. Side Effects jaundice (intrahepatic cholestatic jaundice) pancreatitis nausea changes in appetite altered taste vomiting diarrhea constipation loss of appetite gastric irritation cramping drowsiness and fatigue insomnia headache dizziness dry mouth depression anxiety vertigo restlessness tingling sensations rapid heartbeat shortness of breath and chest pain orthostatic hypotension (this may be worsened by alcohol, barbiturates, or narcotics) acute renal failure acute interstitial nephritis renal stones made of triamterene along with other materials discoloration of urine leukopenia agranulocytosis thrombocytopenia aplastic anemia hemolytic anemia and megaloblastosis xanthopsia temporary blurred vision anaphylaxis sensitivity to light rash hives purpura necrotizing angiitis (vasculitis, cutaneous vasculitis) fever respiratory distress including pneumonitis muscle cramps and weakness decreased sexual performance sialadenitis high potassium levels low potassium levels low sodium levels low magnesium levels low chloride levels high blood sugar levels sugar in urine diabetes mellitus elevated liver enzymes acute transient myopia acute angle-closure glaucoma Warnings hyperkalemia: abnormal elevation of serum potassium levels (greater than or equal to 5.5 mEq/liter) can occur with all potassium-conserving diuretic combinations, including triamterene and hydrochlorothiazide hyperkalemia is more likely to occur in patients with renal impairment, diabetes (even without evidence of renal impairment), or elderly or severely ill patients serum potassium levels must be monitored at frequent intervals especially in patients first receiving triamterene and hydrochlorothiazide, when dosages are changed or with any illness that may influence renal function if hyperkalemia is suspected, (warning signs include paresthesias, muscular weakness, fatigue, flaccid paralysis of the extremities, bradycardia and shock), an electrocardiogram (ECG) should be obtained if hyperkalemia is present, triamterene and hydrochlorothiazide should be discontinued immediately and a thiazide alone should be substituted patients with mild renal functional impairment should not receive this drug without frequent and continuing monitoring of serum electrolytes cumulative drug effects may be observed in patients with impaired renal function triamterene and hydrochlorothiazide should be avoided in diabetic patients if it is employed, serum electrolytes must be frequently monitored triamterene and hydrochlorothiazide should be used cautiously, if at all, with angiotensin-converting enzyme (ACE) inhibitors potassium-conserving therapy should also be avoided in severely ill patients in whom respiratory or metabolic acidosis may occur if triamterene and hydrochlorothiazide is employed, frequent evaluations of acid/base balance and serum electrolytes are necessary hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma symptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiation untreated acute angle-closure glaucoma can lead to permanent vision loss the primary treatment is to discontinue hydrochlorothiazide as rapidly as possible risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy patients receiving triamterene and hydrochlorothiazide should be carefully monitored for fluid or electrolyte imbalances determination of serum electrolytes to detect possible electrolyte imbalance should be performed at appropriate intervals warning signs or symptoms of fluid and electrolyte imbalance include: dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting triamterene and hydrochlorothiazide should be used with caution in patients with impaired hepatic function or progressive liver disease triamterene and hydrochlorothiazide should be used with caution in patients with histories of renal lithiasis triamterene is a weak folic acid antagonist and may contribute to the appearance of megaloblastosis in instances where folic acid stores are decreased hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazide therapy sensitivity reactions to thiazides may occur in patients with or without a history of allergy or bronchial asthma possible exacerbation or activation of systemic lupus erythematosus by thiazides has been reported the safe use of triamterene and hydrochlorothiazide tablets in pregnancy has not been established since there are no adequate and well-controlled studies with triamterene and hydrochlorothiazide tablets in pregnant women the use of thiazides and triamterene in pregnant women requires that the anticipated benefits be weighed against possible hazards to the fetus if use of the combination drug product is deemed essential, the patient should stop nursing safety and effectiveness in pediatric patients have not been established Pregnancy & Lactation the safe use of triamterene and hydrochlorothiazide tablets in pregnancy has not been established since there are no adequate and well-controlled studies with triamterene and hydrochlorothiazide tablets in pregnant women triamterene and hydrochlorothiazide tablets should be used during pregnancy only if the potential benefit justifies the risk to the fetus this drug should be used during pregnancy only if clearly needed the use of thiazides and triamterene in pregnant women requires that the anticipated benefits be weighed against possible hazards to the fetus these hazards include fetal or neonatal jaundice, pancreatitis, thrombocytopenia, and possibly other adverse reactions that have occurred in the adult if use of the combination drug product is deemed essential, the patient should stop nursing Side Effects jaundice (intrahepatic cholestatic jaundice) pancreatitis nausea appetite disturbance taste alteration vomiting diarrhea constipation anorexia gastric irritation cramping drowsiness and fatigue insomnia headache dizziness dry mouth depression anxiety vertigo restlessness paresthesias tachycardia shortness of breath and chest pain orthostatic hypotension (may be aggravated by alcohol, barbiturates or narcotics) acute renal failure acute interstitial nephritis renal stones composed of triamterene in association with other calculus materials urine discoloration leukopenia agranulocytosis thrombocytopenia aplastic anemia hemolytic anemia and megaloblastosis xanthopsia transient blurred vision anaphylaxis photosensitivity rash urticaria purpura necrotizing angiitis (vasculitis, cutaneous vasculitis) fever respiratory distress including pneumonitis muscle cramps and weakness decreased sexual performance sialadenitis hyperkalemia hypokalemia hyponatremia hypomagnesemia hypochloremia hyperglycemia glycosuria diabetes mellitus elevated liver enzymes acute transient myopia acute angle-closure glaucoma
Triamterene and Hydrochlorothiazide Rx tablet BluePoint Laboratories	Popularity – score 0 out of 100 (least-viewed drug)	38 warnings	6 pregnancy and lactation warnings	57 side effects	Trend: was flat over 11 months.
Triamterene and Hydrochlorothiazide® · First marketed 2019 · Label last revised March 29, 2024View full label details → Warnings Hyperkalemia, which is an abnormal elevation of serum potassium levels (greater than or equal to 5.5 mEq/liter), can occur with all potassium-conserving diuretic combinations, including triamterene and hydrochlorothiazide. You are more likely to experience hyperkalemia if you have renal impairment, diabetes (even without evidence of renal impairment), or if you are elderly or severely ill. Your healthcare provider must monitor serum potassium levels at frequent intervals, especially when you first start taking triamterene and hydrochlorothiazide, when dosages are changed, or if you have any illness that may affect renal function. If you suspect hyperkalemia (warning signs include paresthesias, muscular weakness, fatigue, flaccid paralysis of the extremities, bradycardia, and shock), your healthcare provider should obtain an electrocardiogram (ECG). If hyperkalemia is confirmed, you should stop taking triamterene and hydrochlorothiazide immediately, and a thiazide alone should be substituted. If you have mild renal functional impairment, you should not take this drug without frequent and ongoing monitoring of your serum electrolytes. Cumulative drug effects may occur if you have impaired renal function. You should avoid triamterene and hydrochlorothiazide if you have diabetes. If you do take it, your serum electrolytes must be monitored frequently. Use triamterene and hydrochlorothiazide cautiously, if at all, with angiotensin-converting enzyme (ACE) inhibitors. Potassium-conserving therapy should also be avoided if you are severely ill and at risk for respiratory or metabolic acidosis. If you are prescribed triamterene and hydrochlorothiazide, your healthcare provider will need to frequently evaluate your acid/base balance and serum electrolytes. Hydrochlorothiazide can cause an idiosyncratic reaction, leading to acute transient myopia and acute angle-closure glaucoma. Symptoms may include a sudden decrease in visual acuity or ocular pain, typically occurring within hours to weeks after starting the drug. If left untreated, acute angle-closure glaucoma can result in permanent vision loss. The primary treatment is to discontinue hydrochlorothiazide as quickly as possible. If your intraocular pressure remains uncontrolled, prompt medical or surgical treatments may be necessary. Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. If you are taking triamterene and hydrochlorothiazide, your healthcare provider should carefully monitor you for fluid or electrolyte imbalances. Your healthcare provider should perform serum electrolyte tests at appropriate intervals to detect any possible imbalances. Serum and urine electrolyte tests are especially important and should be done frequently if you are vomiting or receiving parenteral fluids. Warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting. Use triamterene and hydrochlorothiazide with caution if you have impaired hepatic function or progressive liver disease. Use triamterene and hydrochlorothiazide with caution if you have a history of renal lithiasis. Triamterene is a weak folic acid antagonist and may contribute to the appearance of megaloblastosis if your folic acid stores are low. Hyperuricemia may occur, or acute gout may be triggered in some patients receiving thiazide therapy. Your insulin requirements may increase, decrease, or remain unchanged if you have diabetes. Latent diabetes mellitus may become apparent during thiazide administration. Sensitivity reactions to thiazides can occur in patients with or without a history of allergy or bronchial asthma. There have been reports of possible exacerbation or activation of systemic lupus erythematosus by thiazides. The safe use of triamterene and hydrochlorothiazide tablets during pregnancy has not been established, as there are no adequate and well-controlled studies in pregnant women. You should use triamterene and hydrochlorothiazide tablets during pregnancy only if the potential benefits justify the risks to the fetus. When considering the use of thiazides and triamterene in pregnant women, weigh the anticipated benefits against possible hazards to the fetus. These hazards may include fetal or neonatal jaundice, pancreatitis, thrombocytopenia, and possibly other adverse reactions that have occurred in adults. The combination of thiazides and triamterene has not been studied in nursing mothers. If the use of this combination drug is deemed essential, you should stop nursing. Safety and effectiveness in pediatric patients have not been established. If you are taking hydrochlorothiazide, be sure to protect your skin from the sun and undergo regular skin cancer screenings. Pregnancy & Lactation The safe use of triamterene and hydrochlorothiazide tablets during pregnancy has not been established, as there are no adequate and well-controlled studies involving pregnant women. You should use triamterene and hydrochlorothiazide tablets during pregnancy only if the potential benefits outweigh the risks to your fetus. This medication should only be used during pregnancy if it is clearly necessary. If you are pregnant, the use of thiazides and triamterene requires careful consideration of the anticipated benefits against possible risks to your fetus. These risks may include fetal or neonatal jaundice, pancreatitis, thrombocytopenia, and potentially other adverse reactions that have been observed in adults. If it is determined that you must use this combination drug, you should stop nursing. Side Effects jaundice (intrahepatic cholestatic jaundice) pancreatitis nausea changes in appetite altered taste vomiting diarrhea constipation loss of appetite gastric irritation cramping drowsiness and fatigue insomnia headache dizziness dry mouth depression anxiety vertigo restlessness tingling sensations rapid heartbeat shortness of breath and chest pain orthostatic hypotension (this may be worsened by alcohol, barbiturates, or narcotics) acute renal failure acute interstitial nephritis renal stones made of triamterene along with other materials urine discoloration low white blood cell count (leukopenia) severe reduction in white blood cells (agranulocytosis) low platelet count (thrombocytopenia) aplastic anemia hemolytic anemia and megaloblastosis yellow vision (xanthopsia) temporary blurred vision anaphylaxis sensitivity to light (photosensitivity) rash hives (urticaria) purple spots on the skin (purpura) necrotizing angiitis (vasculitis, cutaneous vasculitis) fever respiratory distress including pneumonitis muscle cramps and weakness decreased sexual performance inflammation of the salivary glands (sialadenitis) high potassium levels (hyperkalemia) low potassium levels (hypokalemia) low sodium levels (hyponatremia) low magnesium levels (hypomagnesemia) low chloride levels (hypochloremia) high blood sugar (hyperglycemia) sugar in urine (glycosuria) diabetes mellitus elevated liver enzymes acute transient myopia acute angle-closure glaucoma Warnings hyperkalemia: abnormal elevation of serum potassium levels (greater than or equal to 5.5 mEq/liter) can occur with all potassium-conserving diuretic combinations, including triamterene and hydrochlorothiazide hyperkalemia is more likely to occur in patients with renal impairment, diabetes (even without evidence of renal impairment), or elderly or severely ill patients serum potassium levels must be monitored at frequent intervals especially in patients first receiving triamterene and hydrochlorothiazide, when dosages are changed or with any illness that may influence renal function if hyperkalemia is suspected, (warning signs include paresthesias, muscular weakness, fatigue, flaccid paralysis of the extremities, bradycardia and shock), an electrocardiogram (ECG) should be obtained if hyperkalemia is present, triamterene and hydrochlorothiazide should be discontinued immediately and a thiazide alone should be substituted patients with mild renal functional impairment should not receive this drug without frequent and continuing monitoring of serum electrolytes cumulative drug effects may be observed in patients with impaired renal function triamterene and hydrochlorothiazide should be avoided in diabetic patients if it is employed, serum electrolytes must be frequently monitored triamterene and hydrochlorothiazide should be used cautiously, if at all, with angiotensin-converting enzyme (ACE) inhibitors potassium-conserving therapy should also be avoided in severely ill patients in whom respiratory or metabolic acidosis may occur if triamterene and hydrochlorothiazide is employed, frequent evaluations of acid/base balance and serum electrolytes are necessary hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma symptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiation untreated acute angle-closure glaucoma can lead to permanent vision loss the primary treatment is to discontinue hydrochlorothiazide as rapidly as possible prompt medical or surgical treatments may need to be considered if the intraocular pressure remains uncontrolled risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy patients receiving triamterene and hydrochlorothiazide should be carefully monitored for fluid or electrolyte imbalances determination of serum electrolytes to detect possible electrolyte imbalance should be performed at appropriate intervals serum and urine electrolyte determinations are especially important and should be frequently performed when the patient is vomiting or receiving parenteral fluids warning signs or symptoms of fluid and electrolyte imbalance include: dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting triamterene and hydrochlorothiazide should be used with caution in patients with impaired hepatic function or progressive liver disease triamterene and hydrochlorothiazide should be used with caution in patients with histories of renal lithiasis triamterene is a weak folic acid antagonist and may contribute to the appearance of megaloblastosis in instances where folic acid stores are decreased hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazide therapy insulin requirements in diabetic patients may be increased, decreased or unchanged diabetes mellitus which has been latent may become manifest during thiazide administration sensitivity reactions to thiazides may occur in patients with or without a history of allergy or bronchial asthma possible exacerbation or activation of systemic lupus erythematosus by thiazides has been reported the safe use of triamterene and hydrochlorothiazide tablets in pregnancy has not been established since there are no adequate and well-controlled studies with triamterene and hydrochlorothiazide tablets in pregnant women triamterene and hydrochlorothiazide tablets should be used during pregnancy only if the potential benefit justifies the risk to the fetus the use of thiazides and triamterene in pregnant women requires that the anticipated benefits be weighed against possible hazards to the fetus these hazards include fetal or neonatal jaundice, pancreatitis, thrombocytopenia, and possibly other adverse reactions that have occurred in the adult thiazides and triamterene in combination have not been studied in nursing mothers if use of the combination drug product is deemed essential, the patient should stop nursing safety and effectiveness in pediatric patients have not been established instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening Pregnancy & Lactation the safe use of triamterene and hydrochlorothiazide tablets in pregnancy has not been established since there are no adequate and well-controlled studies with triamterene and hydrochlorothiazide tablets in pregnant women triamterene and hydrochlorothiazide tablets should be used during pregnancy only if the potential benefit justifies the risk to the fetus this drug should be used during pregnancy only if clearly needed the use of thiazides and triamterene in pregnant women requires that the anticipated benefits be weighed against possible hazards to the fetus these hazards include fetal or neonatal jaundice, pancreatitis, thrombocytopenia, and possibly other adverse reactions that have occurred in the adult if use of the combination drug product is deemed essential, the patient should stop nursing Side Effects jaundice (intrahepatic cholestatic jaundice) pancreatitis nausea appetite disturbance taste alteration vomiting diarrhea constipation anorexia gastric irritation cramping drowsiness and fatigue insomnia headache dizziness dry mouth depression anxiety vertigo restlessness paresthesias tachycardia shortness of breath and chest pain orthostatic hypotension (may be aggravated by alcohol, barbiturates or narcotics) acute renal failure acute interstitial nephritis renal stones composed of triamterene in association with other calculus materials urine discoloration leukopenia agranulocytosis thrombocytopenia aplastic anemia hemolytic anemia and megaloblastosis xanthopsia transient blurred vision anaphylaxis photosensitivity rash urticaria purpura necrotizing angiitis (vasculitis, cutaneous vasculitis) fever respiratory distress including pneumonitis muscle cramps and weakness decreased sexual performance sialadenitis hyperkalemia hypokalemia hyponatremia hypomagnesemia hypochloremia hyperglycemia glycosuria diabetes mellitus elevated liver enzymes acute transient myopia acute angle-closure glaucoma
Triamterene and Hydrochlorothiazide Rx tablet Apotex Corp.	Popularity – score 0 out of 100 (least-viewed drug)	30 warnings	5 pregnancy and lactation warnings	73 side effects	Trend: was flat over 11 months.
Triamterene and Hydrochlorothiazide® · First marketed 2009 · Label last revised July 10, 2025View full label details → Warnings You may experience an abnormal elevation of serum potassium levels with all potassium-conserving diuretic combinations. Hyperkalemia is more likely to occur if you have renal impairment, diabetes, or if you are elderly or severely ill. Your healthcare provider must monitor serum potassium levels at frequent intervals, especially when you first start taking triamterene and hydrochlorothiazide. If you suspect hyperkalemia, an electrocardiogram (ECG) should be obtained. If hyperkalemia is confirmed, you should discontinue triamterene and hydrochlorothiazide immediately. If you have mild renal functional impairment, you should not receive this drug without frequent and ongoing monitoring of serum electrolytes. You should avoid triamterene and hydrochlorothiazide if you have diabetes. If you do use this medication, your serum electrolytes must be monitored frequently. Use triamterene and hydrochlorothiazide cautiously, if at all, with angiotensin-converting enzyme (ACE) inhibitors. Potassium-conserving therapy should also be avoided if you are severely ill and at risk for respiratory or metabolic acidosis. Frequent evaluations of acid/base balance and serum electrolytes are necessary if you are taking triamterene and hydrochlorothiazide. Hydrochlorothiazide can cause an idiosyncratic reaction, leading to acute transient myopia and acute angle-closure glaucoma. If left untreated, acute angle-closure glaucoma can result in permanent vision loss. The primary treatment is to discontinue hydrochlorothiazide as quickly as possible. If you are taking triamterene and hydrochlorothiazide, your healthcare provider should carefully monitor you for fluid or electrolyte imbalances. Your healthcare provider should perform serum electrolyte tests at appropriate intervals to detect any possible imbalances. Warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting. Use triamterene and hydrochlorothiazide with caution if you have impaired hepatic function or progressive liver disease. Use triamterene and hydrochlorothiazide with caution if you have a history of renal lithiasis. Triamterene is a weak folic acid antagonist and may contribute to the appearance of megaloblastosis if your folic acid stores are decreased. Hyperuricemia may occur, or acute gout may be triggered in certain patients receiving thiazide therapy. Thiazides may decrease serum PBI levels without signs of thyroid disturbance. Your insulin requirements may increase, decrease, or remain unchanged if you have diabetes. Sensitivity reactions to thiazides may occur, even if you do not have a history of allergy or bronchial asthma. There have been reports of possible exacerbation or activation of systemic lupus erythematosus by thiazides. The safe use of triamterene and hydrochlorothiazide during pregnancy has not been established, as there are no adequate and well-controlled studies in pregnant women. If you are pregnant, the use of thiazides and triamterene requires weighing the anticipated benefits against possible risks to the fetus. If the combination drug is deemed essential, you should stop nursing. Safety and effectiveness in pediatric patients have not been established. If you are taking hydrochlorothiazide, be sure to protect your skin from the sun and undergo regular skin cancer screenings. Pregnancy & Lactation If you find that using this combination drug is essential, you should stop nursing. The safe use of triamterene and hydrochlorothiazide during pregnancy has not been established, as there are no adequate and well-controlled studies involving pregnant women. You should use triamterene and hydrochlorothiazide during pregnancy only if the potential benefits outweigh the risks to your fetus. This drug should be used during pregnancy only if it is clearly necessary. If you are pregnant, the use of thiazides and triamterene requires careful consideration of the anticipated benefits against possible risks to your fetus. Side Effects jaundice (intrahepatic cholestatic jaundice) pancreatitis nausea changes in appetite altered taste vomiting diarrhea constipation anorexia gastric irritation cramping drowsiness and fatigue insomnia headache dizziness dry mouth depression anxiety vertigo restlessness tingling sensations rapid heartbeat shortness of breath and chest pain orthostatic hypotension (this may be worsened by alcohol, barbiturates, or narcotics) acute renal failure acute interstitial nephritis renal stones made of triamterene along with other materials urine discoloration low white blood cell count (leukopenia) severe reduction in white blood cells (agranulocytosis) low platelet count (thrombocytopenia) aplastic anemia hemolytic anemia megaloblastosis yellow vision (xanthopsia) temporary blurred vision anaphylaxis sensitivity to light (photosensitivity) rash hives (urticaria) purpura inflammation of blood vessels (necrotizing angiitis, cutaneous vasculitis) fever respiratory distress including pneumonitis muscle cramps and weakness decreased sexual performance inflammation of the salivary glands (sialadenitis) high potassium levels (hyperkalemia) low potassium levels (hypokalemia) low sodium levels (hyponatremia) low magnesium levels (hypomagnesemia) low chloride levels (hypochloremia) high blood sugar (hyperglycemia) sugar in urine (glycosuria) diabetes mellitus elevated liver enzymes acute transient myopia acute angle-closure glaucoma dry mouth thirst weakness lethargy drowsiness restlessness muscle pains or cramps muscle fatigue low blood pressure (hypotension) reduced urine output (oliguria) rapid heartbeat (tachycardia) gastrointestinal disturbances such as nausea and vomiting hepatic coma high uric acid levels (hyperuricemia) acute gout Warnings abnormal elevation of serum potassium levels can occur with all potassium-conserving diuretic combinations hyperkalemia is more likely to occur in patients with renal impairment, diabetes, or elderly or severely ill patients serum potassium levels must be monitored at frequent intervals especially in patients first receiving triamterene and hydrochlorothiazide if hyperkalemia is suspected, an electrocardiogram (ECG) should be obtained if hyperkalemia is present, triamterene and hydrochlorothiazide should be discontinued immediately patients with mild renal functional impairment should not receive this drug without frequent and continuing monitoring of serum electrolytes triamterene and hydrochlorothiazide should be avoided in diabetic patients if it is employed, serum electrolytes must be frequently monitored triamterene and hydrochlorothiazide should be used cautiously, if at all, with angiotensin-converting enzyme (ACE) inhibitors potassium-conserving therapy should also be avoided in severely ill patients in whom respiratory or metabolic acidosis may occur frequent evaluations of acid/base balance and serum electrolytes are necessary if triamterene and hydrochlorothiazide is employed hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma untreated acute angle-closure glaucoma can lead to permanent vision loss the primary treatment is to discontinue hydrochlorothiazide as rapidly as possible patients receiving triamterene and hydrochlorothiazide should be carefully monitored for fluid or electrolyte imbalances determination of serum electrolytes to detect possible electrolyte imbalance should be performed at appropriate intervals warning signs or symptoms of fluid and electrolyte imbalance include: dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia and gastrointestinal disturbances such as nausea and vomiting triamterene and hydrochlorothiazide should be used with caution in patients with impaired hepatic function or progressive liver disease triamterene and hydrochlorothiazide should be used with caution in patients with histories of renal lithiasis triamterene is a weak folic acid antagonist and may contribute to the appearance of megaloblastosis in instances where folic acid stores are decreased hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazide therapy the thiazides may decrease serum PBI levels without signs of thyroid disturbance insulin requirements in diabetic patients may be increased, decreased or unchanged sensitivity reactions to thiazides may occur in patients with or without a history of allergy or bronchial asthma possible exacerbation or activation of systemic lupus erythematosus by thiazides has been reported the safe use of triamterene and hydrochlorothiazide in pregnancy has not been established since there are no adequate and well controlled studies with triamterene and hydrochlorothiazide in pregnant women the use of thiazides and triamterene in pregnant women requires that the anticipated benefits be weighed against possible hazards to the fetus if use of the combination drug product is deemed essential, the patient should stop nursing safety and effectiveness in pediatric patients have not been established instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening Pregnancy & Lactation if use of the combination drug product is deemed essential, the patient should stop nursing the safe use of triamterene and hydrochlorothiazide in pregnancy has not been established since there are no adequate and well controlled studies with triamterene and hydrochlorothiazide in pregnant women triamterene and hydrochlorothiazide should be used during pregnancy only if the potential benefit justifies the risk to the fetus this drug should be used during pregnancy only if clearly needed the use of thiazides and triamterene in pregnant women requires that the anticipated benefits be weighed against possible hazards to the fetus Side Effects jaundice (intrahepatic cholestatic jaundice) pancreatitis nausea appetite disturbance taste alteration vomiting diarrhea constipation anorexia gastric irritation cramping drowsiness and fatigue insomnia headache dizziness dry mouth depression anxiety vertigo restlessness paresthesias tachycardia shortness of breath and chest pain orthostatic hypotension (may be aggravated by alcohol, barbiturates or narcotics) acute renal failure acute interstitial nephritis renal stones composed of triamterene in association with other calculus materials urine discoloration leukopenia agranulocytosis thrombocytopenia aplastic anemia hemolytic anemia megaloblastosis xanthopsia transient blurred vision anaphylaxis photosensitivity rash urticaria purpura necrotizing angiitis (vasculitis, cutaneous vasculitis) fever respiratory distress including pneumonitis muscle cramps and weakness decreased sexual performance sialadenitis hyperkalemia hypokalemia hyponatremia hypomagnesemia hypochloremia hyperglycemia glycosuria diabetes mellitus elevated liver enzymes acute transient myopia acute angle-closure glaucoma dryness of mouth thirst weakness lethargy drowsiness restlessness muscle pains or cramps muscular fatigue hypotension oliguria tachycardia gastrointestinal disturbances such as nausea and vomiting hepatic coma hyperuricemia acute gout
Triamterene and Hydrochlorothiazide Rx capsule Macleods Pharmaceuticals Limited	Popularity – score 0 out of 100 (least-viewed drug)	21 warnings	0 pregnancy and lactation warnings	58 side effects	Trend: was flat over 11 months.
Triamterene and Hydrochlorothiazide® · First marketed 2025 · Label last revised March 4, 2025View full label details → Warnings You may experience an abnormal elevation of serum potassium levels with any potassium-sparing diuretic combinations. If you have renal impairment or diabetes, you are at a higher risk for hyperkalemia. Your healthcare provider will need to monitor your serum potassium levels frequently, especially when you first start taking triamterene and hydrochlorothiazide. If you suspect hyperkalemia, an electrocardiogram (ECG) should be obtained. If hyperkalemia is confirmed, you should stop taking triamterene and hydrochlorothiazide capsules immediately. If you have mild renal functional impairment, you should not take this drug without regular monitoring of your serum electrolytes. Your healthcare provider must frequently monitor your serum electrolytes if you are using triamterene and hydrochlorothiazide capsules and have diabetes. Potassium-sparing therapy should be avoided if you are severely ill and at risk for respiratory or metabolic acidosis. Hydrochlorothiazide can cause an unusual reaction, leading to acute transient myopia and acute angle-closure glaucoma. If left untreated, acute angle-closure glaucoma can result in permanent vision loss. If you are taking hydrochlorothiazide, be sure to protect your skin from the sun and have regular skin cancer screenings. Use thiazides with caution if you have impaired hepatic function. If you show serious hypokalemia, you should stop taking triamterene and hydrochlorothiazide capsules and start potassium chloride supplementation. Be aware that electrolyte imbalances may worsen with diuretics, so this should be considered during your therapy with triamterene and hydrochlorothiazide capsules. Use triamterene and hydrochlorothiazide capsules cautiously if you have a history of renal stones. Exercise caution when taking nonsteroidal anti-inflammatory agents with triamterene and hydrochlorothiazide. You generally should not take lithium with diuretics, as they can reduce its renal clearance and increase the risk of lithium toxicity. The safe use of triamterene and hydrochlorothiazide capsules during pregnancy has not been established. If you are pregnant, the use of thiazides and triamterene should be carefully considered, weighing the anticipated benefits against potential risks to the fetus. If the combination drug is deemed essential, you should stop nursing. Safety and effectiveness in children have not been established. Pregnancy & Lactation The safe use of triamterene and hydrochlorothiazide capsules during pregnancy has not been established, as there are no adequate and well-controlled studies involving pregnant women. You should use triamterene and hydrochlorothiazide capsules during pregnancy only if the potential benefits outweigh the risks to your fetus. This medication should only be used during pregnancy if it is clearly necessary. When considering the use of thiazides and triamterene in pregnant women, it's important to weigh the anticipated benefits against any possible risks to the fetus. The effects of thiazides and triamterene in combination have not been studied in nursing mothers. Triamterene may appear in animal milk, and this could also happen in humans. Thiazides are excreted in human breast milk. If the use of this combination drug is deemed essential, you should stop nursing. Side Effects anaphylaxis rash urticaria reactions similar to subacute cutaneous lupus erythematosus photosensitivity arrhythmia postural hypotension diabetes mellitus hyperkalemia hypokalemia hyponatremia acidosis hypercalcemia hyperglycemia glycosuria hyperuricemia hypochloremia jaundice and/or liver enzyme abnormalities pancreatitis nausea and vomiting diarrhea constipation abdominal pain acute renal failure (one case of irreversible renal failure has been reported) interstitial nephritis renal stones primarily composed of triamterene elevated BUN serum creatinine abnormal urinary sediment leukopenia thrombocytopenia and purpura megaloblastic anemia muscle cramps weakness fatigue dizziness headache dry mouth impotence sialadenitis paresthesias vertigo xanthopsia transient blurred vision allergic pneumonitis pulmonary edema respiratory distress necrotizing vasculitis exacerbation of lupus aplastic anemia agranulocytosis hemolytic anemia thrombocytopenia and pancreatitis—rarely, in newborns whose mothers have received thiazides during pregnancy erythema multiforme, including Stevens-Johnson syndrome exfoliative dermatitis, including toxic epidermal necrolysis increased risk of non-melanoma skin cancer acute transient myopia acute angle-closure glaucoma Warnings abnormal elevation of serum potassium levels can occur with all potassium-sparing diuretic combinations hyperkalemia is more likely to occur in patients with renal impairment and diabetes serum potassium levels must be monitored at frequent intervals especially in patients first receiving triamterene and hydrochlorothiazide if hyperkalemia is suspected, an electrocardiogram (ECG) should be obtained if hyperkalemia is present, triamterene and hydrochlorothiazide capsules should be discontinued immediately patients with mild renal functional impairment should not receive this drug without frequent and continuing monitoring of serum electrolytes serum electrolytes must be frequently monitored if triamterene and hydrochlorothiazide capsules are used in diabetic patients potassium-sparing therapy should also be avoided in severely ill patients in whom respiratory or metabolic acidosis may occur hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma untreated acute angle-closure glaucoma can lead to permanent vision loss instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening thiazides should be used with caution in patients with impaired hepatic function if serious hypokalemia is demonstrated, triamterene and hydrochlorothiazide capsules should be discontinued and potassium chloride supplementation initiated electrolyte imbalance may also be aggravated by diuretics and should be considered during therapy with triamterene and hydrochlorothiazide capsules triamterene and hydrochlorothiazide capsules should be used with caution in patients with a history of renal stones caution is advised in administering nonsteroidal anti-inflammatory agents with triamterene and hydrochlorothiazide lithium generally should not be given with diuretics because they reduce its renal clearance and increase the risk of lithium toxicity the safe use of triamterene and hydrochlorothiazide capsules in pregnancy has not been established the use of thiazides and triamterene in pregnant women requires that the anticipated benefit be weighed against possible hazards to the fetus if use of the combination drug product is deemed essential, the patient should stop nursing safety and effectiveness in pediatric patients have not been established Pregnancy & Lactation No pregnancy & lactation warnings reported. Side Effects anaphylaxis rash urticaria subacute cutaneous lupus erythematosus-like reactions photosensitivity arrhythmia postural hypotension diabetes mellitus hyperkalemia hypokalemia hyponatremia acidosis hypercalcemia hyperglycemia glycosuria hyperuricemia hypochloremia jaundice and/or liver enzyme abnormalities pancreatitis nausea and vomiting diarrhea constipation abdominal pain acute renal failure (one case of irreversible renal failure has been reported) interstitial nephritis renal stones composed primarily of triamterene elevated BUN serum creatinine abnormal urinary sediment leukopenia thrombocytopenia and purpura megaloblastic anemia muscle cramps weakness fatigue dizziness headache dry mouth impotence sialadenitis paresthesias vertigo xanthopsia transient blurred vision allergic pneumonitis pulmonary edema respiratory distress necrotizing vasculitis exacerbation of lupus aplastic anemia agranulocytosis hemolytic anemia thrombocytopenia and pancreatitis–rarely, in newborns whose mothers have received thiazides during pregnancy erythema multiforme, including Stevens-Johnson syndrome exfoliative dermatitis, including toxic epidermal necrolysis increased risk of non-melanoma skin cancer acute transient myopia acute angle-closure glaucoma
Triamterene and Hydrochlorothiazide Rx capsule Zydus Lifesciences Limited	Popularity – score 0 out of 100 (least-viewed drug)	21 warnings	6 pregnancy and lactation warnings	54 side effects	Trend: was flat over 11 months.
Triamterene and Hydrochlorothiazide® · First marketed 2020 · Label last revised October 31, 2023View full label details → Warnings You may experience an abnormal elevation of serum potassium levels with all potassium-sparing diuretic combinations, including triamterene and hydrochlorothiazide capsules. Hyperkalemia is more likely to occur in individuals with renal impairment, diabetes, the elderly, or those who are severely ill. Your healthcare provider should monitor serum potassium levels at frequent intervals, especially when you first start taking triamterene and hydrochlorothiazide capsules, when your dosages change, or if you have any illness that may affect renal function. Exercise caution when taking triamterene and hydrochlorothiazide capsules if you have diabetes, as thiazides may cause hyperglycemia, glycosuria, and alter your insulin requirements. Diabetes mellitus may develop during thiazide administration. Use thiazides with caution if you have impaired hepatic function. Thiazides can precipitate hepatic coma in individuals with severe liver disease. Administer triamterene and hydrochlorothiazide capsules cautiously and be alert for early signs of impending coma, such as confusion, drowsiness, and tremor. If you notice an increase in mental confusion, discontinue triamterene and hydrochlorothiazide capsules for a few days. Pay attention to other factors that may lead to hepatic coma, such as blood in the gastrointestinal tract or pre-existing potassium depletion. If serious hypokalemia is confirmed by repeat serum potassium tests, you should discontinue triamterene and hydrochlorothiazide capsules and start potassium chloride supplementation. Less serious hypokalemia should be evaluated in light of other coexisting conditions and treated accordingly. Your healthcare provider should perform serum determinations of electrolytes, which are particularly important if you are vomiting excessively or receiving fluids parenterally. Possible fluid and electrolyte imbalance may be indicated by warning signs such as dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pain or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal symptoms. Use triamterene and hydrochlorothiazide capsules with caution if you have a history of renal stones. If you are taking hydrochlorothiazide, protect your skin from the sun and undergo regular skin cancer screenings. The safe use of triamterene and hydrochlorothiazide capsules during pregnancy has not been established, as there are no adequate and well-controlled studies in pregnant women. You should use triamterene and hydrochlorothiazide capsules during pregnancy only if the potential benefit justifies the risk to the fetus. When considering the use of thiazides and triamterene in pregnant women, weigh the anticipated benefit against possible hazards to the fetus. If the use of this combination drug is deemed essential, you should stop nursing. Safety and effectiveness in pediatric patients have not been established. Pregnancy & Lactation The safe use of triamterene and hydrochlorothiazide capsules during pregnancy has not been established, as there are no adequate and well-controlled studies involving pregnant women. You should use triamterene and hydrochlorothiazide capsules during pregnancy only if the potential benefits outweigh the risks to your fetus. This medication should only be used during pregnancy if it is clearly necessary. When considering the use of thiazides and triamterene in pregnant women, it's important to weigh the anticipated benefits against possible risks to the fetus. These risks may include fetal or neonatal jaundice, pancreatitis, thrombocytopenia, and other adverse reactions that have been observed in adults. If the combination drug is deemed essential, you should stop nursing. Side Effects anaphylaxis rash urticaria reactions similar to subacute cutaneous lupus erythematosus photosensitivity arrhythmia postural hypotension diabetes mellitus hyperkalemia hypokalemia hyponatremia acidosis hypercalcemia hyperglycemia glycosuria hyperuricemia hypochloremia jaundice and/or liver enzyme abnormalities pancreatitis nausea and vomiting diarrhea constipation abdominal pain acute renal failure (one case of irreversible renal failure has been reported) interstitial nephritis renal stones primarily made of triamterene elevated BUN and serum creatinine abnormal urinary sediment leukopenia thrombocytopenia and purpura megaloblastic anemia muscle cramps weakness fatigue dizziness headache dry mouth impotence sialadenitis paresthesias vertigo xanthopsia transient blurred vision allergic pneumonitis pulmonary edema respiratory distress necrotizing vasculitis exacerbation of lupus aplastic anemia agranulocytosis hemolytic anemia thrombocytopenia and pancreatitis—rarely, in newborns whose mothers have received thiazides during pregnancy erythema multiforme, including Stevens-Johnson syndrome exfoliative dermatitis, including toxic epidermal necrolysis Warnings abnormal elevation of serum potassium levels can occur with all potassium-sparing diuretic combinations, including triamterene and hydrochlorothiazide capsules hyperkalemia is more likely to occur in patients with renal impairment and diabetes and in the elderly or severely ill serum potassium levels must be monitored at frequent intervals especially in patients first receiving triamterene and hydrochlorothiazide capsules, when dosages are changed, or with any illness that may influence renal function caution should be exercised when administering triamterene and hydrochlorothiazide capsules to patients with diabetes, since thiazides may cause hyperglycemia, glycosuria, and alter insulin requirements in diabetes diabetes mellitus may become manifest during thiazide administration thiazides should be used with caution in patients with impaired hepatic function thiazides can precipitate hepatic coma in patients with severe liver disease administer triamterene and hydrochlorothiazide capsules cautiously and be alert for early signs of impending coma such as confusion, drowsiness, and tremor if mental confusion increases, discontinue triamterene and hydrochlorothiazide capsules for a few days attention must be given to other factors that may precipitate hepatic coma, such as blood in the gastrointestinal tract or pre-existing potassium depletion if serious hypokalemia is demonstrated by repeat serum potassium determinations, triamterene and hydrochlorothiazide capsules should be discontinued and potassium chloride supplementation initiated less serious hypokalemia should be evaluated with regard to other coexisting conditions and treated accordingly serum determinations of electrolytes should be performed and are particularly important if the patient is vomiting excessively or receiving fluids parenterally possible fluid and electrolyte imbalance may be indicated by warning signs such as: dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pain or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal symptoms triamterene and hydrochlorothiazide capsules should be used with caution in patients with a history of renal stones instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening the safe use of triamterene and hydrochlorothiazide capsules in pregnancy has not been established since there are no adequate and well-controlled studies with triamterene and hydrochlorothiazide in pregnant women triamterene and hydrochlorothiazide capsules should be used during pregnancy only if the potential benefit justifies the risk to the fetus the use of thiazides and triamterene in pregnant women requires that the anticipated benefit be weighed against possible hazards to the fetus if use of the combination drug product is deemed essential, the patient should stop nursing safety and effectiveness in pediatric patients have not been established Pregnancy & Lactation the safe use of triamterene and hydrochlorothiazide capsules in pregnancy has not been established since there are no adequate and well-controlled studies with triamterene and hydrochlorothiazide in pregnant women triamterene and hydrochlorothiazide capsules should be used during pregnancy only if the potential benefit justifies the risk to the fetus this drug should be used during pregnancy only if clearly needed the use of thiazides and triamterene in pregnant women requires that the anticipated benefit be weighed against possible hazards to the fetus these hazards include fetal or neonatal jaundice, pancreatitis, thrombocytopenia, and possible other adverse reactions which have occurred in the adult if use of the combination drug product is deemed essential, the patient should stop nursing Side Effects anaphylaxis rash urticaria subacute cutaneous lupus erythematosus-like reactions photosensitivity arrhythmia postural hypotension diabetes mellitus hyperkalemia hypokalemia hyponatremia acidosis hypercalcemia hyperglycemia glycosuria hyperuricemia hypochloremia jaundice and/or liver enzyme abnormalities pancreatitis nausea and vomiting diarrhea constipation abdominal pain acute renal failure (one case of irreversible renal failure has been reported) interstitial nephritis renal stones composed primarily of triamterene elevated BUN and serum creatinine abnormal urinary sediment leukopenia thrombocytopenia and purpura megaloblastic anemia muscle cramps weakness fatigue dizziness headache dry mouth impotence sialadenitis paresthesias vertigo xanthopsia transient blurred vision allergic pneumonitis pulmonary edema respiratory distress necrotizing vasculitis exacerbation of lupus aplastic anemia agranulocytosis hemolytic anemia thrombocytopenia and pancreatitis–rarely, in newborns whose mothers have received thiazides during pregnancy erythema multiforme, including Stevens-Johnson syndrome exfoliative dermatitis, including toxic epidermal necrolysis
Triamterene and Hydrochlorothiazide Rx capsule Zydus Pharmaceuticals (USA) Inc.	Popularity – score 0 out of 100 (least-viewed drug)	23 warnings	6 pregnancy and lactation warnings	55 side effects	Trend: was flat over 11 months.
Triamterene and Hydrochlorothiazide® · First marketed 2019 · Label last revised February 23, 2019View full label details → Warnings You may experience an abnormal elevation of serum potassium levels with all potassium-sparing diuretic combinations, including triamterene and hydrochlorothiazide capsules. Hyperkalemia is more likely to occur in you if you have renal impairment, diabetes (even without evidence of renal impairment), or if you are elderly or severely ill. Your healthcare provider must monitor your serum potassium levels at frequent intervals, especially when you first start taking triamterene and hydrochlorothiazide capsules, when your dosages change, or if you have any illness that may affect your renal function. Exercise caution when taking triamterene and hydrochlorothiazide capsules if you have diabetes, as thiazides may cause hyperglycemia, glycosuria, and alter your insulin requirements. Diabetes mellitus may become apparent during your thiazide treatment. Use thiazides with caution if you have impaired hepatic function. They can precipitate hepatic coma if you have severe liver disease. Administer triamterene and hydrochlorothiazide capsules cautiously and be alert for early signs of impending coma, such as confusion, drowsiness, and tremor. If you notice an increase in mental confusion, discontinue triamterene and hydrochlorothiazide capsules for a few days. Pay attention to other factors that may lead to hepatic coma, such as blood in your gastrointestinal tract or preexisting potassium depletion. If serious hypokalemia (serum potassium less than 3 mEq/L) is confirmed by repeat serum potassium tests, you should discontinue triamterene and hydrochlorothiazide capsules and start potassium chloride supplementation. Less serious hypokalemia should be evaluated in light of other coexisting conditions and treated accordingly. Your healthcare provider should perform serum determinations of electrolytes, which are particularly important if you are vomiting excessively or receiving fluids parenterally. Possible fluid and electrolyte imbalance may be indicated by warning signs such as dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pain or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal symptoms. Use triamterene and hydrochlorothiazide capsules with caution if you have a history of renal stones. Caution is advised when taking nonsteroidal anti-inflammatory agents with triamterene and hydrochlorothiazide capsules. Lithium generally should not be taken with diuretics because they reduce its renal clearance and increase the risk of lithium toxicity. Thiazides have also been shown to increase the paralyzing effect of nondepolarizing muscle relaxants such as tubocurarine; therefore, caution should be observed if you are undergoing surgery. The safe use of triamterene and hydrochlorothiazide capsules during pregnancy has not been established, as there are no adequate and well-controlled studies in pregnant women. This drug should be used during pregnancy only if clearly needed. When considering the use of thiazides and triamterene in pregnant women, the anticipated benefit must be weighed against possible hazards to the fetus. If the use of the combination drug product is deemed essential, you should stop nursing. Safety and effectiveness in pediatric patients have not been established. Pregnancy & Lactation The safe use of triamterene and hydrochlorothiazide capsules during pregnancy has not been established, as there are no adequate and well-controlled studies involving pregnant women. You should use triamterene and hydrochlorothiazide capsules during pregnancy only if the potential benefits outweigh the risks to your fetus. This medication should only be used during pregnancy if it is clearly necessary. When considering the use of thiazides and triamterene in pregnant women, it's important to weigh the anticipated benefits against possible risks to the fetus. These risks may include fetal or neonatal jaundice, pancreatitis, thrombocytopenia, and other adverse reactions that have been observed in adults. If the use of this combination medication is deemed essential, you should stop nursing. Side Effects anaphylaxis rash urticaria reactions similar to subacute cutaneous lupus erythematosus photosensitivity arrhythmia postural hypotension diabetes mellitus hyperkalemia hypokalemia hyponatremia acidosis hypercalcemia hyperglycemia glycosuria hyperuricemia hypochloremia jaundice and/or liver enzyme abnormalities pancreatitis nausea and vomiting diarrhea constipation abdominal pain acute renal failure (one case of irreversible renal failure has been reported) interstitial nephritis renal stones primarily made of triamterene elevated BUN serum creatinine abnormal urinary sediment leukopenia thrombocytopenia and purpura megaloblastic anemia muscle cramps weakness fatigue dizziness headache dry mouth impotence sialadenitis paresthesias vertigo xanthopsia transient blurred vision allergic pneumonitis pulmonary edema respiratory distress necrotizing vasculitis exacerbation of lupus aplastic anemia agranulocytosis hemolytic anemia thrombocytopenia and pancreatitis—rarely, in newborns whose mothers have received thiazides during pregnancy erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis Warnings abnormal elevation of serum potassium levels can occur with all potassium-sparing diuretic combinations, including triamterene and hydrochlorothiazide capsules hyperkalemia is more likely to occur in patients with renal impairment and diabetes (even without evidence of renal impairment), and in the elderly or severely ill serum potassium levels must be monitored at frequent intervals especially in patients first receiving triamterene and hydrochlorothiazide capsules, when dosages are changed or with any illness that may influence renal function caution should be exercised when administering triamterene and hydrochlorothiazide capsules to patients with diabetes, since thiazides may cause hyperglycemia, glycosuria, and alter insulin requirements in diabetes diabetes mellitus may become manifest during thiazide administration thiazides should be used with caution in patients with impaired hepatic function they can precipitate hepatic coma in patients with severe liver disease administer triamterene and hydrochlorothiazide capsules cautiously and be alert for such early signs of impending coma as confusion, drowsiness, and tremor if mental confusion increases discontinue triamterene and hydrochlorothiazide capsules for a few days attention must be given to other factors that may precipitate hepatic coma, such as blood in the gastrointestinal tract or preexisting potassium depletion if serious hypokalemia (serum potassium less than 3 mEq/L) is demonstrated by repeat serum potassium determinations, triamterene and hydrochlorothiazide capsules should be discontinued and potassium chloride supplementation initiated less serious hypokalemia should be evaluated with regard to other coexisting conditions and treated accordingly serum determinations of electrolytes should be performed, and are particularly important if the patient is vomiting excessively or receiving fluids parenterally possible fluid and electrolyte imbalance may be indicated by such warning signs as: dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pain or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal symptoms triamterene and hydrochlorothiazide capsules should be used with caution in patients with a history of renal stones caution is advised in administering nonsteroidal anti-inflammatory agents with triamterene and hydrochlorothiazide capsules lithium generally should not be given with diuretics because they reduce its renal clearance and increase the risk of lithium toxicity thiazides have also been shown to increase the paralyzing effect of nondepolarizing muscle relaxants such as tubocurarine; consequently caution should be observed in patients undergoing surgery the safe use of triamterene and hydrochlorothiazide capsules in pregnancy has not been established since there are no adequate and well-controlled studies with triamterene and hydrochlorothiazide in pregnant women this drug should be used during pregnancy only if clearly needed the use of thiazides and triamterene in pregnant women requires that the anticipated benefit be weighed against possible hazards to the fetus if use of the combination drug product is deemed essential, the patient should stop nursing safety and effectiveness in pediatric patients have not been established Pregnancy & Lactation the safe use of triamterene and hydrochlorothiazide capsules in pregnancy has not been established since there are no adequate and well-controlled studies with triamterene and hydrochlorothiazide in pregnant women triamterene and hydrochlorothiazide capsules should be used during pregnancy only if the potential benefit justifies the risk to the fetus this drug should be used during pregnancy only if clearly needed the use of thiazides and triamterene in pregnant women requires that the anticipated benefit be weighed against possible hazards to the fetus these hazards include fetal or neonatal jaundice, pancreatitis, thrombocytopenia, and possible other adverse reactions which have occurred in the adult if use of the combination drug product is deemed essential, the patient should stop nursing Side Effects anaphylaxis rash urticaria subacute cutaneous lupus erythematosus-like reactions photosensitivity arrhythmia postural hypotension diabetes mellitus hyperkalemia hypokalemia hyponatremia acidosis hypercalcemia hyperglycemia glycosuria hyperuricemia hypochloremia jaundice and/or liver enzyme abnormalities pancreatitis nausea and vomiting diarrhea constipation abdominal pain acute renal failure (one case of irreversible renal failure has been reported) interstitial nephritis renal stones composed primarily of triamterene elevated BUN serum creatinine abnormal urinary sediment leukopenia thrombocytopenia and purpura megaloblastic anemia muscle cramps weakness fatigue dizziness headache dry mouth impotence sialadenitis paresthesias vertigo xanthopsia transient blurred vision allergic pneumonitis pulmonary edema respiratory distress necrotizing vasculitis exacerbation of lupus aplastic anemia agranulocytosis hemolytic anemia thrombocytopenia and pancreatitis–rarely, in newborns whose mothers have received thiazides during pregnancy erythema multiforme including Stevens-Johnson syndrome exfoliative dermatitis including toxic epidermal necrolysis
Triamterene and Hydrochlorothiazide Rx capsule Sandoz Inc	Popularity – score 0 out of 100 (least-viewed drug)	28 warnings	5 pregnancy and lactation warnings	54 side effects	Trend: was flat over 11 months.
Triamterene and Hydrochlorothiazide® · First marketed 1997 · Label last revised December 29, 2025View full label details → Warnings You may experience an abnormal elevation of serum potassium levels (≥5.5 mEq/liter) with all potassium-sparing diuretic combinations, including triamterene and hydrochlorothiazide. Hyperkalemia is more likely to occur in you if you have renal impairment, diabetes (even without evidence of renal impairment), or if you are elderly or severely ill. Your healthcare provider must monitor your serum potassium levels at frequent intervals, especially when you first start taking triamterene and hydrochlorothiazide, when your dosages change, or if you have any illness that may affect your renal function. If you suspect hyperkalemia (warning signs include paresthesias, muscular weakness, fatigue, flaccid paralysis of the extremities, bradycardia, and shock), your healthcare provider should obtain an electrocardiogram (ECG). If hyperkalemia is confirmed, you should stop taking triamterene and hydrochlorothiazide immediately, and a thiazide alone should be substituted. If you have mild renal functional impairment, you should not take this drug without frequent and ongoing monitoring of your serum electrolytes. Cumulative drug effects may occur if you have impaired renal function. Your serum electrolytes must be frequently monitored if you are using triamterene and hydrochlorothiazide and have diabetes. You should avoid potassium-sparing therapy if you are severely ill and at risk for respiratory or metabolic acidosis. Frequent evaluations of your acid/base balance and serum electrolytes are necessary if you are taking triamterene and hydrochlorothiazide. Hydrochlorothiazide can cause an idiosyncratic reaction, leading to acute transient myopia and acute angle-closure glaucoma. Symptoms may include a sudden decrease in visual acuity or ocular pain, typically occurring within hours to weeks after starting the drug. If left untreated, acute angle-closure glaucoma can result in permanent vision loss. You should exercise caution when taking triamterene and hydrochlorothiazide if you have diabetes, as thiazides may cause hyperglycemia, glycosuria, and alter your insulin requirements. Thiazides should be used cautiously if you have impaired hepatic function. Administer triamterene and hydrochlorothiazide carefully, and be alert for early signs of impending coma, such as confusion, drowsiness, and tremor. If you notice an increase in mental confusion, you should discontinue triamterene and hydrochlorothiazide for a few days. If serious hypokalemia (serum potassium < 3.0 mEq/L) is confirmed by repeat serum potassium tests, you should stop taking triamterene and hydrochlorothiazide and start potassium chloride supplementation. Less serious hypokalemia should be evaluated in relation to other existing conditions and treated accordingly. Serum determinations of electrolytes should be performed, especially if you are experiencing excessive vomiting or receiving fluids parenterally. Possible fluid and electrolyte imbalance may be indicated by warning signs such as dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pain or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal symptoms. You should use triamterene and hydrochlorothiazide with caution if you have a history of renal stones. Caution is advised when taking nonsteroidal anti-inflammatory agents with triamterene and hydrochlorothiazide. The safe use of triamterene and hydrochlorothiazide during pregnancy has not been established, as there are no adequate and well-controlled studies in pregnant women. Thiazides and triamterene can cross the placental barrier and appear in cord blood. If thiazides and triamterene are deemed essential during pregnancy, the anticipated benefits must be weighed against possible risks to the fetus. If the combination drug product is necessary, you should stop nursing. Safety and effectiveness in children have not been established. Pregnancy & Lactation If you find that using this combination drug product is essential, you should stop nursing. The safe use of triamterene and hydrochlorothiazide during pregnancy has not been established, as there are no adequate and well-controlled studies involving pregnant women. You should use triamterene and hydrochlorothiazide during pregnancy only if the potential benefits outweigh the risks to your fetus. This drug should be used during pregnancy only if it is clearly necessary. When considering the use of thiazides and triamterene in pregnant women, you need to weigh the anticipated benefits against any possible hazards to the fetus. Side Effects You may experience anaphylaxis. You might develop a rash. Urticaria could occur. There may be subacute cutaneous lupus erythematosus-like reactions. Photosensitivity is a possibility. You could experience arrhythmia. Postural hypotension may happen. You might develop diabetes mellitus. Hyperkalemia could occur. You may experience hypokalemia. Hyponatremia is a possibility. Acidosis might occur. You could experience hypercalcemia. Hyperglycemia may happen. Glycosuria could occur. You might experience hyperuricemia. Hypochloremia is a possibility. Jaundice and/or liver enzyme abnormalities may occur. You could develop pancreatitis. Nausea and vomiting might happen. Diarrhea could occur. You may experience constipation. Abdominal pain is a possibility. Acute renal failure may occur (one case of irreversible renal failure has been reported). You might experience interstitial nephritis. Renal stones composed primarily of triamterene could develop. You may have elevated BUN and serum creatinine. Abnormal urinary sediment might occur. You could experience leukopenia. Thrombocytopenia and purpura may happen. You might develop megaloblastic anemia. Muscle cramps could occur. You may experience weakness. Fatigue is a possibility. Dizziness might happen. You could experience headaches. Dry mouth may occur. Impotence is a possibility. You might develop sialadenitis. Paresthesias could occur. You may experience vertigo. Xanthopsia is a possibility. Transient blurred vision might happen. You could experience allergic pneumonitis. Pulmonary edema may occur. Respiratory distress is a possibility. You might develop necrotizing vasculitis. Exacerbation of lupus could occur. You may experience aplastic anemia. Agranulocytosis is a possibility. Hemolytic anemia may occur. Thrombocytopenia and pancreatitis – rarely, in newborns whose mothers have received thiazides during pregnancy. You might develop erythema multiforme, including Stevens-Johnson syndrome. Exfoliative dermatitis, including toxic epidermal necrolysis, could occur. Warnings abnormal elevation of serum potassium levels (≥5.5 mEq/liter) can occur with all potassium-sparing diuretic combinations, including triamterene and hydrochlorothiazide hyperkalemia is more likely to occur in patients with renal impairment and diabetes (even without evidence of renal impairment) and in the elderly or severely ill serum potassium levels must be monitored at frequent intervals especially in patients first receiving triamterene and hydrochlorothiazide, when dosages are changed, or with any illness that may influence renal function if hyperkalemia is suspected (warning signs include paresthesias, muscular weakness, fatigue, flaccid paralysis of the extremities, bradycardia, and shock), an electrocardiogram (ECG) should be obtained if hyperkalemia is present, triamterene and hydrochlorothiazide should be discontinued immediately and a thiazide alone should be substituted patients with mild renal functional impairment should not receive this drug without frequent and continuing monitoring of serum electrolytes cumulative drug effects may be observed in patients with impaired renal function serum electrolytes must be frequently monitored if triamterene and hydrochlorothiazide is used in diabetic patients potassium-sparing therapy should also be avoided in severely ill patients in whom respiratory or metabolic acidosis may occur frequent evaluations of acid/base balance and serum electrolytes are necessary if triamterene and hydrochlorothiazide is employed hydrochlorothiazide can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma symptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiation untreated acute angle-closure glaucoma can lead to permanent vision loss caution should be exercised when administering triamterene and hydrochlorothiazide to patients with diabetes, since thiazides may cause hyperglycemia, glycosuria, and alter insulin requirements in diabetes thiazides should be used with caution in patients with impaired hepatic function administer triamterene and hydrochlorothiazide cautiously and be alert for early signs of impending coma such as confusion, drowsiness, and tremor if mental confusion increases, discontinue triamterene and hydrochlorothiazide for a few days if serious hypokalemia (serum potassium < 3.0 mEq/L) is demonstrated by repeat serum potassium determinations, triamterene and hydrochlorothiazide should be discontinued and potassium chloride supplementation initiated less serious hypokalemia should be evaluated with regard to other coexisting conditions and treated accordingly serum determinations of electrolytes should be performed and are particularly important if the patient is vomiting excessively or receiving fluids parenterally possible fluid and electrolyte imbalance may be indicated by warning signs such as: dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pain or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal symptoms triamterene and hydrochlorothiazide should be used with caution in patients with a history of renal stones caution is advised in administering nonsteroidal anti-inflammatory agents with triamterene and hydrochlorothiazide the safe use of triamterene and hydrochlorothiazide in pregnancy has not been established since there are no adequate and well-controlled studies with triamterene and hydrochlorothiazide in pregnant women thiazides and triamterene have been shown to cross the placental barrier and appear in cord blood the use of thiazides and triamterene in pregnant women requires that the anticipated benefit be weighed against possible hazards to the fetus if use of the combination drug product is deemed essential, the patient should stop nursing safety and effectiveness in pediatric patients have not been established Pregnancy & Lactation if use of the combination drug product is deemed essential, the patient should stop nursing the safe use of triamterene and hydrochlorothiazide in pregnancy has not been established since there are no adequate and well-controlled studies with triamterene and hydrochlorothiazide in pregnant women triamterene and hydrochlorothiazide should be used during pregnancy only if the potential benefit justifies the risk to the fetus this drug should be used during pregnancy only if clearly needed the use of thiazides and triamterene in pregnant women requires that the anticipated benefit be weighed against possible hazards to the fetus Side Effects anaphylaxis rash urticaria subacute cutaneous lupus erythematosus-like reactions photosensitivity arrhythmia postural hypotension diabetes mellitus hyperkalemia hypokalemia hyponatremia acidosis hypercalcemia hyperglycemia glycosuria hyperuricemia hypochloremia jaundice and/or liver enzyme abnormalities pancreatitis nausea and vomiting diarrhea constipation abdominal pain acute renal failure (one case of irreversible renal failure has been reported) interstitial nephritis renal stones composed primarily of triamterene elevated BUN and serum creatinine abnormal urinary sediment leukopenia thrombocytopenia and purpura megaloblastic anemia muscle cramps weakness fatigue dizziness headache dry mouth impotence sialadenitis paresthesias vertigo xanthopsia transient blurred vision allergic pneumonitis pulmonary edema respiratory distress necrotizing vasculitis exacerbation of lupus aplastic anemia agranulocytosis hemolytic anemia thrombocytopenia and pancreatitis – rarely, in newborns whose mothers have received thiazides during pregnancy erythema multiforme, including Stevens-Johnson syndrome exfoliative dermatitis, including toxic epidermal necrolysis
Triamterene and Hydrochlorothiazide Rx tablet Zydus Pharmaceuticals (USA) Inc.	Popularity – score 0 out of 100 (least-viewed drug)	19 warnings	4 pregnancy and lactation warnings	56 side effects	Trend: was flat over 11 months.
Triamterene and Hydrochlorothiazide® · First marketed 2018 · Label last revised August 26, 2023View full label details → Warnings You may experience an abnormal elevation of serum potassium levels when using any potassium-conserving diuretic combinations. Hyperkalemia is more likely to occur if you have renal impairment, diabetes, or if you are elderly or severely ill. Your healthcare provider will need to monitor your serum potassium levels at frequent intervals, especially when you first start taking triamterene and hydrochlorothiazide. If you are taking triamterene and hydrochlorothiazide, your healthcare provider should carefully monitor you for any fluid or electrolyte imbalances. Your healthcare provider should perform serum electrolyte tests at appropriate intervals to check for possible electrolyte imbalances. Serum and urine electrolyte tests are especially important and should be done frequently if you are vomiting or receiving parenteral fluids. Be aware of warning signs or symptoms of fluid and electrolyte imbalance, which include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, low blood pressure, reduced urine output, rapid heartbeat, and gastrointestinal disturbances like nausea and vomiting. Use triamterene and hydrochlorothiazide with caution if you have impaired hepatic function or progressive liver disease. If you have a history of renal lithiasis, you should also use triamterene and hydrochlorothiazide with caution. Triamterene is a weak folic acid antagonist and may contribute to the appearance of megaloblastosis if your folic acid stores are low. Hyperuricemia may occur, or acute gout may be triggered in some patients receiving thiazide therapy. Sensitivity reactions to thiazides can happen, even if you do not have a history of allergy or bronchial asthma. There have been reports of possible exacerbation or activation of systemic lupus erythematosus due to thiazides. Therefore, exercise caution when taking non-steroidal anti-inflammatory agents with triamterene and hydrochlorothiazide. If you are taking angiotensin-converting enzyme inhibitors, be very cautious about using potassium-sparing agents, as this greatly increases the risk of hyperkalemia. The safe use of triamterene and hydrochlorothiazide during pregnancy has not been established, as there are no adequate and well-controlled studies in pregnant women. If you are pregnant, the use of thiazides and triamterene requires weighing the anticipated benefits against possible risks to the fetus. If the combination drug is deemed essential, you should stop nursing. Safety and effectiveness in pediatric patients have not been established. Pregnancy & Lactation The safe use of triamterene and hydrochlorothiazide during pregnancy has not been established, as there are no adequate and well-controlled studies involving pregnant women. You should use triamterene and hydrochlorothiazide during pregnancy only if the potential benefits outweigh the risks to your fetus. This medication should only be used during pregnancy if it is clearly necessary. If your healthcare provider determines that the combination drug is essential, you should stop nursing. Side Effects jaundice (intrahepatic cholestatic jaundice) pancreatitis nausea changes in appetite altered taste vomiting diarrhea constipation loss of appetite gastric irritation cramping drowsiness and fatigue insomnia headache dizziness dry mouth depression anxiety vertigo restlessness tingling sensations rapid heartbeat shortness of breath and chest pain orthostatic hypotension (this may be worsened by alcohol, barbiturates, or narcotics) acute renal failure acute interstitial nephritis renal stones made of triamterene along with other materials urine discoloration leukopenia agranulocytosis thrombocytopenia aplastic anemia hemolytic anemia megaloblastosis xanthopsia temporary blurred vision anaphylaxis photosensitivity rash hives purpura necrotizing angiitis (vasculitis, cutaneous vasculitis) fever respiratory distress including pneumonitis muscle cramps and weakness decreased sexual performance sialadenitis high potassium levels low potassium levels low sodium levels low magnesium levels low chloride levels high blood sugar sugar in urine diabetes mellitus elevated liver enzymes Warnings abnormal elevation of serum potassium levels can occur with all potassium-conserving diuretic combinations hyperkalemia is more likely to occur in patients with renal impairment, diabetes, or elderly or severely ill patients serum potassium levels must be monitored at frequent intervals especially in patients first receiving triamterene and hydrochlorothiazide patients receiving triamterene and hydrochlorothiazide should be carefully monitored for fluid or electrolyte imbalances determination of serum electrolytes to detect possible electrolyte imbalance should be performed at appropriate intervals serum and urine electrolyte determinations are especially important and should be frequently performed when the patient is vomiting or receiving parenteral fluids warning signs or symptoms of fluid and electrolyte imbalance include: dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia and gastrointestinal disturbances such as nausea and vomiting triamterene and hydrochlorothiazide should be used with caution in patients with impaired hepatic function or progressive liver disease triamterene and hydrochlorothiazide should be used with caution in patients with histories of renal lithiasis triamterene is a weak folic acid antagonist and may contribute to the appearance of megaloblastosis in instances where folic acid stores are decreased hyperuricemia may occur or acute gout may be precipitated in certain patients receiving thiazide therapy sensitivity reactions to thiazides may occur in patients with or without a history of allergy or bronchial asthma possible exacerbation or activation of systemic lupus erythematosus by thiazides has been reported caution is therefore advised when administering non-steroidal anti-inflammatory agents with triamterene and hydrochlorothiazide potassium-sparing agents should be used very cautiously, if at all, in conjunction with angiotensin-converting enzyme inhibitors due to a greatly increased risk of hyperkalemia the safe use of triamterene and hydrochlorothiazide in pregnancy has not been established since there are no adequate and well controlled studies with triamterene and hydrochlorothiazide in pregnant women the use of thiazides and triamterene in pregnant women requires that the anticipated benefits be weighed against possible hazards to the fetus if use of the combination drug product is deemed essential, the patient should stop nursing safety and effectiveness in pediatric patients have not been established Pregnancy & Lactation the safe use of triamterene and hydrochlorothiazide in pregnancy has not been established since there are no adequate and well controlled studies with triamterene and hydrochlorothiazide in pregnant women triamterene and hydrochlorothiazide should be used during pregnancy only if the potential benefit justifies the risk to the fetus this drug should be used during pregnancy only if clearly needed if use of the combination drug product is deemed essential, the patient should stop nursing Side Effects jaundice (intrahepatic cholestatic jaundice) pancreatitis nausea appetite disturbance taste alteration vomiting diarrhea constipation anorexia gastric irritation cramping drowsiness and fatigue insomnia headache dizziness dry mouth depression anxiety vertigo restlessness paresthesias tachycardia shortness of breath and chest pain orthostatic hypotension (may be aggravated by alcohol, barbiturates or narcotics) acute renal failure acute interstitial nephritis renal stones composed of triamterene in association with other calculus materials urine discoloration leukopenia agranulocytosis thrombocytopenia aplastic anemia hemolytic anemia megaloblastosis xanthopsia transient blurred vision anaphylaxis photosensitivity rash urticaria purpura necrotizing angiitis (vasculitis, cutaneous vasculitis) fever respiratory distress including pneumonitis muscle cramps and weakness decreased sexual performance sialadenitis hyperkalemia hypokalemia hyponatremia hypomagnesemia hypochloremia hyperglycemia glycosuria diabetes mellitus elevated liver enzymes
Valsartan and Hydrochlorothiazide Rx tablet, film coated Alembic Pharmaceuticals Limited	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	11 pregnancy and lactation warnings	8 side effects	Trend: fell 23% over the year; peaks in May, Jul.
Valsartan and Hydrochlorothiazide® · First marketed 2016 · Label last revised January 27, 2023View full label details → Warnings If you find out you are pregnant, please stop taking valsartan and hydrochlorothiazide tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus and may even lead to serious complications. Make sure to correct any volume depletion before starting treatment. Keep an eye out for any signs of fluid or electrolyte imbalance. Your healthcare provider should regularly monitor your renal function and potassium levels if you are at risk. Be aware that this medication may worsen or trigger systemic lupus erythematosus. Watch for symptoms of acute angle-closure glaucoma. Pregnancy & Lactation Using drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal renal function and increase the risk of morbidity and death for both the fetus and neonate. Oligohydramnios that results from this can be linked to fetal lung hypoplasia and skeletal deformations. If you find out you are pregnant, please discontinue valsartan and hydrochlorothiazide as soon as possible. These adverse outcomes are typically associated with the use of these drugs during the second and third trimesters of pregnancy. In the rare case that there is no suitable alternative to therapy with drugs affecting the renin-angiotensin system for you, please discuss the potential risks to your fetus with your healthcare provider. If oligohydramnios is observed, valsartan and hydrochlorothiazide should be discontinued unless they are deemed lifesaving for you. Thiazides can cross the placenta, and the concentrations in the umbilical vein can be similar to those in your maternal plasma. Using thiazides during pregnancy carries a risk of fetal or neonatal jaundice or thrombocytopenia. These drugs should not be used to treat hypertension in pregnant women. The use of hydrochlorothiazide for other indications during pregnancy should be avoided. You should decide whether to continue nursing or to discontinue the drug, considering how important the medication is for your health. Side Effects You may experience a headache. You might feel dizzy. There is a chance of nasopharyngitis (2.4% vs. 1.9%). You could experience hypotension. Be aware of potential fluid or electrolyte imbalances. If you have certain conditions, you may face renal function and potassium issues. There is a possibility of exacerbation or activation of systemic lupus erythematosus. You should be cautious of acute angle-closure glaucoma. Warnings when pregnancy is detected, discontinue valsartan and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and even death to the developing fetus correct volume-depletion prior to initiation observe for signs of fluid or electrolyte imbalance monitor renal function and potassium in susceptible patients exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma Pregnancy & Lactation use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations when pregnancy is detected, discontinue valsartan and hydrochlorothiazide as soon as possible these adverse outcomes are usually associated with use of these drugs in the second and third trimester of pregnancy in the unusual case that there is no appropriate alternative to therapy with drugs affecting the renin-angiotensin system for a particular patient, apprise the mother of the potential risk to the fetus if oligohydramnios is observed, discontinue valsartan and hydrochlorothiazide, unless it is considered lifesaving for the mother thiazides can cross the placenta, and concentrations reached in the umbilical vein approach those in the maternal plasma use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia these drugs should not be used to treat hypertension in pregnant women the use of hydrochlorothiazide for other indications in pregnancy should be avoided a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother Side Effects headache dizziness nasopharyngitis (2.4% vs. 1.9%) hypotension fluid or electrolyte imbalance renal function and potassium issues in susceptible patients exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma
Valsartan and Hydrochlorothiazide Rx tablet, film coated Mylan Pharmaceuticals Inc.	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	12 pregnancy and lactation warnings	7 side effects	Trend: fell 23% over the year; peaks in May, Jul.
Valsartan and Hydrochlorothiazide® · First marketed 2012 · Label last revised April 27, 2023View full label details → Warnings If you find out you are pregnant, please stop taking valsartan and hydrochlorothiazide tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm your developing fetus, potentially leading to serious injury or death. Make sure to correct any volume depletion before starting treatment. Keep an eye out for any signs of fluid or electrolyte imbalance. Your healthcare provider should monitor your renal function and potassium levels if you are at risk. Be aware that this medication may worsen or trigger systemic lupus erythematosus. Watch for symptoms of acute angle-closure glaucoma. Pregnancy & Lactation Valsartan and hydrochlorothiazide tablets can cause harm to the fetus if you take them while pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please stop taking valsartan and hydrochlorothiazide tablets as soon as possible. High blood pressure during pregnancy raises your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for your baby of intrauterine growth restriction and intrauterine death. Oligohydramnios in pregnant women using medications that affect the renin-angiotensin system during the second and third trimesters can lead to reduced kidney function in the fetus, resulting in anuria, renal failure, underdeveloped lungs, skeletal deformities (including skull hypoplasia), low blood pressure, and even death. Using thiazides during pregnancy is linked to a risk of jaundice or low platelet counts in the fetus or newborn. These medications should not be used to manage high blood pressure in pregnant women. It's best to avoid using hydrochlorothiazide for other conditions during pregnancy. Valsartan can be found in rat milk. Hydrochlorothiazide is present in human breast milk. Breastfeeding is not recommended while you are being treated with valsartan and hydrochlorothiazide tablets. Side Effects You may experience a headache. Dizziness can occur. There is a chance of nasopharyngitis (2.4% vs. 1.9%). Hypotension may be a concern. You could face a fluid or electrolyte imbalance. Be aware that there may be an exacerbation or activation of systemic lupus erythematosus. Acute angle-closure glaucoma is a potential risk. Warnings when pregnancy is detected, discontinue valsartan and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume depletion prior to initiation observe for signs of fluid or electrolyte imbalance monitor renal function and potassium in susceptible patients exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma Pregnancy & Lactation valsartan and hydrochlorothiazide tablets can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected discontinue valsartan and hydrochlorothiazide tablets as soon as possible hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death oligohydramnios in pregnant women who use drugs affecting the renin-angiotensin system in the second and third trimesters of pregnancy can result in reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension and death use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia these drugs should not be used to treat hypertension in pregnant women the use of hydrochlorothiazide for other indications in pregnancy should be avoided valsartan is present in rat milk hydrochlorothiazide is present in human breast milk breastfeeding is not recommended during treatment with valsartan and hydrochlorothiazide tablets Side Effects headache dizziness nasopharyngitis (2.4% vs. 1.9%) hypotension fluid or electrolyte imbalance exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma
Valsartan and Hydrochlorothiazide Rx tablettablet, film coated Macleods Pharmaceuticals Limited	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	11 pregnancy and lactation warnings	7 side effects	Trend: fell 23% over the year; peaks in May, Jul.
Valsartan and Hydrochlorothiazide® · First marketed 2013 · Label last revised November 2, 2022View full label details → Warnings If you find out you are pregnant, please stop taking valsartan and hydrochlorothiazide tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm your developing fetus, potentially leading to serious injury or death. Make sure to correct any volume depletion before starting treatment. Keep an eye out for any signs of fluid or electrolyte imbalance. Your healthcare provider should monitor your renal function and potassium levels if you are at risk. Be aware that this medication may worsen or trigger systemic lupus erythematosus. Watch for symptoms of acute angle-closure glaucoma. Pregnancy & Lactation Taking valsartan and hydrochlorothiazide tablets can harm your fetus if you are pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of your pregnancy can reduce your baby's kidney function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please stop taking valsartan and hydrochlorothiazide tablets as soon as possible. High blood pressure during pregnancy raises your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for your baby, including intrauterine growth restriction and intrauterine death. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can lead to oligohydramnios, which may result in reduced kidney function for your baby, leading to anuria, renal failure, underdeveloped lungs, skeletal deformities, low blood pressure, and even death. Thiazides can cross the placenta, and the levels in the umbilical vein can be similar to those in your bloodstream. Using thiazides during pregnancy may increase the risk of jaundice or low platelet counts in your baby. These medications should not be used to manage high blood pressure in pregnant women. It is best to avoid using hydrochlorothiazide for other conditions during pregnancy. If you are nursing, please be advised that breastfeeding is not recommended while you are being treated with valsartan and hydrochlorothiazide tablets. Side Effects You may experience a headache. Dizziness can occur. There is a chance of nasopharyngitis (2.4% vs. 1.9%). You might notice hypotension. Be aware of potential fluid or electrolyte imbalances. This medication may cause an exacerbation or activation of systemic lupus erythematosus. Acute angle-closure glaucoma is a possible side effect. Warnings when pregnancy is detected, discontinue valsartan and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume depletion prior to initiation observe for signs of fluid or electrolyte imbalance monitor renal function and potassium in susceptible patients exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma Pregnancy & Lactation valsartan and hydrochlorothiazide tablet can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected discontinue valsartan and hydrochlorothiazide tablet as soon as possible hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death oligohydramnios in pregnant women who use drugs affecting the renin-angiotensin system in the second and third trimesters of pregnancy can result in reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension and death thiazides can cross the placenta, and concentrations reached in the umbilical vein approach those in the maternal plasma use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia these drugs should not be used to treat hypertension in pregnant women the use of hydrochlorothiazide for other indications in pregnancy should be avoided advise a nursing woman that breastfeeding is not recommended during treatment with valsartan and hydrochlorothiazide tablet Side Effects headache dizziness nasopharyngitis (2.4% vs. 1.9%) hypotension fluid or electrolyte imbalance exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma
Valsartan and Hydrochlorothiazide Rx tablet, film coated Alembic Pharmaceuticals Inc.	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	11 pregnancy and lactation warnings	8 side effects	Trend: fell 23% over the year; peaks in May, Jul.
Valsartan and Hydrochlorothiazide® · First marketed 2016 · Label last revised June 10, 2024View full label details → Warnings If you find out you are pregnant, please stop taking valsartan and hydrochlorothiazide tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm your developing fetus, potentially leading to serious injury or death. Make sure to correct any volume depletion before starting treatment. Keep an eye out for any signs of fluid or electrolyte imbalance. Your healthcare provider should monitor your renal function and potassium levels if you are at risk. Be aware that this medication may worsen or trigger systemic lupus erythematosus. Watch for symptoms of acute angle-closure glaucoma. Pregnancy & Lactation Valsartan and hydrochlorothiazide can cause harm to the fetus if you are pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal kidney function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please discontinue valsartan and hydrochlorothiazide as soon as possible. High blood pressure during pregnancy raises your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for your baby, including intrauterine growth restriction and intrauterine death. Oligohydramnios in pregnant women using medications that affect the renin-angiotensin system during the second and third trimesters can lead to reduced kidney function in the fetus, resulting in anuria, renal failure, underdeveloped lungs, skeletal deformities such as skull hypoplasia, low blood pressure, and even death. Thiazides can cross the placenta, and the levels in the umbilical vein can be similar to those in your bloodstream. Using thiazides during pregnancy may increase the risk of jaundice or low platelet counts in your baby. These medications should not be used to treat high blood pressure in pregnant women. The use of hydrochlorothiazide for other conditions during pregnancy should be avoided. If you are nursing, please be advised that breastfeeding is not recommended while you are being treated with valsartan and hydrochlorothiazide. Side Effects You may experience a headache. You might feel dizzy. There is a chance of nasopharyngitis (2.4% vs. 1.9%). You could experience hypotension. Be aware of potential fluid or electrolyte imbalances. If you are a susceptible patient, there may be renal function and potassium issues. This medication could exacerbate or activate systemic lupus erythematosus. You should be cautious of acute angle-closure glaucoma. Warnings when pregnancy is detected, discontinue valsartan and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume-depletion prior to initiation observe for signs of fluid or electrolyte imbalance monitor renal function and potassium in susceptible patients exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma Pregnancy & Lactation valsartan and hydrochlorothiazide can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected discontinue valsartan and hydrochlorothiazide as soon as possible hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death oligohydramnios in pregnant women who use drugs affecting the renin-angiotensin system in the second and third trimesters of pregnancy can result in reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension and death thiazides can cross the placenta, and concentrations reached in the umbilical vein approach those in the maternal plasma use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia these drugs should not be used to treat hypertension in pregnant women the use of hydrochlorothiazide for other indications in pregnancy should be avoided advise a nursing woman that breastfeeding is not recommended during treatment with valsartan and hydrochlorothiazide Side Effects headache dizziness nasopharyngitis (2.4% vs. 1.9%) hypotension fluid or electrolyte imbalance renal function and potassium issues in susceptible patients exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma
Valsartan and Hydrochlorothiazide Rx tablet, film coated Zydus Lifesciences Limited	Popularity – score 0 out of 100 (least-viewed drug)	0 warnings	0 pregnancy and lactation warnings	0 side effects	Trend: fell 23% over the year; peaks in May, Jul.
Valsartan and Hydrochlorothiazide® · First marketed 2020 · Label last revised November 5, 2022View full label details → Warnings No warnings reported. Pregnancy & Lactation No pregnancy & lactation warnings reported. Side Effects No side effects reported. Warnings No warnings reported. Pregnancy & Lactation No pregnancy & lactation warnings reported. Side Effects No side effects reported.
Valsartan and Hydrochlorothiazide Rx tablet, film coated Aurobindo Pharma Limited	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	9 pregnancy and lactation warnings	7 side effects	Trend: fell 23% over the year; peaks in May, Jul.
Valsartan and Hydrochlorothiazide® · First marketed 2013 · Label last revised June 15, 2024View full label details → Warnings If you find out you are pregnant, please stop taking valsartan and hydrochlorothiazide as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. Make sure to correct any volume depletion before starting treatment. Keep an eye out for any signs of fluid or electrolyte imbalance. Your healthcare provider should monitor your renal function and potassium levels if you are at risk. Be aware that this medication may worsen or trigger systemic lupus erythematosus. Watch for symptoms of acute angle-closure glaucoma. Pregnancy & Lactation Valsartan and hydrochlorothiazide can cause harm to your fetus if you are pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce your baby's kidney function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please stop taking valsartan and hydrochlorothiazide as soon as possible. High blood pressure during pregnancy raises your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for your baby of intrauterine growth restriction and intrauterine death. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can lead to oligohydramnios, which may result in reduced kidney function for your baby, leading to anuria, renal failure, underdeveloped lungs, skeletal deformities, low blood pressure, and even death. Taking thiazides during pregnancy is linked to a risk of jaundice or low platelet counts in your baby. These medications should not be used to manage high blood pressure in pregnant women. It is not recommended to breastfeed while being treated with valsartan and hydrochlorothiazide. Side Effects You may experience a headache. Dizziness can occur. There is a chance of nasopharyngitis (2.4% vs. 1.9%). You might notice hypotension. Be aware of potential fluid or electrolyte imbalances. This medication could lead to an exacerbation or activation of systemic lupus erythematosus. Acute angle-closure glaucoma is a possible side effect. Warnings when pregnancy is detected, discontinue valsartan and hydrochlorothiazide as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume depletion prior to initiation observe for signs of fluid or electrolyte imbalance monitor renal function and potassium in susceptible patients exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma Pregnancy & Lactation valsartan and hydrochlorothiazide can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected discontinue valsartan and hydrochlorothiazide as soon as possible hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death oligohydramnios in pregnant women who use drugs affecting the renin-angiotensin system in the second and third trimesters of pregnancy can result in reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension and death use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia these drugs should not be used to treat hypertension in pregnant women breastfeeding is not recommended during treatment with valsartan and hydrochlorothiazide Side Effects headache dizziness nasopharyngitis (2.4% vs. 1.9%) hypotension fluid or electrolyte imbalance exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma
Valsartan and Hydrochlorothiazide Rx tablet, film coated Amneal Pharmaceuticals LLC	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	0 pregnancy and lactation warnings	7 side effects	Trend: fell 23% over the year; peaks in May, Jul.
Valsartan and Hydrochlorothiazide® · First marketed 2023 · Label last revised February 2, 2019View full label details → Warnings If you find out you are pregnant, please stop taking valsartan and hydrochlorothiazide tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. Make sure to correct any volume depletion before starting treatment. Keep an eye out for any signs of fluid or electrolyte imbalance. Your healthcare provider should monitor your renal function and potassium levels if you are at risk. Be aware that this medication may worsen or trigger systemic lupus erythematosus. Watch for symptoms of acute angle-closure glaucoma. Pregnancy & Lactation Using drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy can reduce fetal renal function and increase the risk of morbidity and death for both the fetus and neonate. If you find out you are pregnant, please discontinue valsartan and hydrochlorothiazide as soon as possible. In the rare case that there is no suitable alternative to therapy with drugs affecting the renin-angiotensin system for you, your healthcare provider should inform you about the potential risks to your fetus. If oligohydramnios is observed, valsartan and hydrochlorothiazide should be discontinued, unless your healthcare provider considers it lifesaving for you. Thiazides can cross the placenta, and the concentrations in the umbilical vein can be similar to those in your maternal plasma. Using thiazides during pregnancy may be associated with a risk of fetal or neonatal jaundice or thrombocytopenia. It is advisable to avoid using hydrochlorothiazide for other indications during pregnancy. It is currently unknown whether valsartan is excreted in human milk. Hydrochlorothiazide is excreted in human breast milk. You should decide whether to continue nursing or discontinue the drug, considering how important the medication is for your health. Side Effects You may experience a headache. Dizziness can occur. There is a chance of nasopharyngitis (2.4% vs. 1.9%). You might notice hypotension. Be aware of potential fluid or electrolyte imbalances. This medication may cause an exacerbation or activation of systemic lupus erythematosus. Acute angle-closure glaucoma is a possible side effect. Warnings when pregnancy is detected, discontinue valsartan and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume depletion prior to initiation observe for signs of fluid or electrolyte imbalance monitor renal function and potassium in susceptible patients exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma Pregnancy & Lactation No pregnancy & lactation warnings reported. Side Effects headache dizziness nasopharyngitis (2.4% vs. 1.9%) hypotension fluid or electrolyte imbalance exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma
Valsartan and Hydrochlorothiazide Rx tablet, film coated Amneal Pharmaceuticals of New York LLC	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	9 pregnancy and lactation warnings	9 side effects	Trend: fell 23% over the year; peaks in May, Jul.
Valsartan and Hydrochlorothiazide® · First marketed 2023 · Label last revised May 8, 2023View full label details → Warnings If you find out you are pregnant, please stop taking valsartan and hydrochlorothiazide tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm your developing fetus, potentially leading to serious injury or death. Make sure to correct any volume depletion before starting treatment. Keep an eye out for any signs of fluid or electrolyte imbalance. Your healthcare provider should monitor your renal function and potassium levels if you are at risk. Be aware that this medication may worsen or trigger systemic lupus erythematosus. Watch for symptoms of acute angle-closure glaucoma. Pregnancy & Lactation Valsartan and hydrochlorothiazide can cause harm to your fetus if you are pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of your pregnancy can reduce your fetus's renal function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please discontinue valsartan and hydrochlorothiazide as soon as possible. Oligohydramnios in pregnant women using medications that impact the renin-angiotensin system during the second and third trimesters can lead to reduced fetal renal function, resulting in anuria, renal failure, fetal lung hypoplasia, skeletal deformations (including skull hypoplasia), hypotension, and even death. Thiazides can cross the placenta, and the concentrations in the umbilical vein can be similar to those in your plasma. Using thiazides during pregnancy may increase the risk of fetal or neonatal jaundice or thrombocytopenia. These medications should not be used to treat hypertension in pregnant women. The use of hydrochlorothiazide for other conditions (like heart disease) during pregnancy should be avoided. You and your healthcare provider should be aware that oligohydramnios may not be noticeable until after the fetus has experienced irreversible injury. Side Effects You may experience a headache. You might feel dizzy. There is a chance of nasopharyngitis (2.4% vs. 1.9%). You could experience hypotension. Be aware of potential fluid or electrolyte imbalance. Your renal function may be impaired. You might have a potassium imbalance. There is a possibility of exacerbation or activation of systemic lupus erythematosus. You should be cautious of acute angle-closure glaucoma. Warnings when pregnancy is detected, discontinue valsartan and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume depletion prior to initiation observe for signs of fluid or electrolyte imbalance monitor renal function and potassium in susceptible patients exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma Pregnancy & Lactation valsartan and hydrochlorothiazide can cause fetal harm when administered to a pregnant woman use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected discontinue valsartan and hydrochlorothiazide as soon as possible oligohydramnios in pregnant women who use drugs affecting the renin-angiotensin system in the second and third trimesters of pregnancy can result in reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension and death thiazides can cross the placenta, and concentrations reached in the umbilical vein approach those in the maternal plasma use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia these drugs should not be used to treat hypertension in pregnant women the use of hydrochlorothiazide for other indications (e.g., heart disease) in pregnancy should be avoided patients and physicians should be aware that oligohydramnios may not appear until after the fetus has sustained irreversible injury Side Effects headache dizziness nasopharyngitis (2.4% vs. 1.9%) hypotension fluid or electrolyte imbalance renal function impairment potassium imbalance exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma
Valsartan and Hydrochlorothiazide Rx tablet, film coated Lupin Pharmaceuticals, Inc.	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	11 pregnancy and lactation warnings	6 side effects	Trend: fell 23% over the year; peaks in May, Jul.
Valsartan and Hydrochlorothiazide® · First marketed 2013 · Label last revised November 30, 2023View full label details → Warnings If you find out you are pregnant, please stop taking valsartan and hydrochlorothiazide tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. Make sure to correct any volume depletion before starting treatment. Keep an eye out for any signs of fluid or electrolyte imbalance. Your healthcare provider should monitor your renal function and potassium levels if you are at risk. Be aware that this medication may worsen or trigger systemic lupus erythematosus. Watch for symptoms of acute angle-closure glaucoma. Pregnancy & Lactation Valsartan and hydrochlorothiazide can cause harm to the fetus if you are pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of your pregnancy can reduce fetal kidney function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please discontinue valsartan and hydrochlorothiazide as soon as possible. High blood pressure during pregnancy raises your risk for pre-eclampsia, gestational diabetes, premature delivery, and complications during delivery. High blood pressure can also increase the risk for your baby of intrauterine growth restriction and intrauterine death. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can lead to oligohydramnios, which may result in reduced kidney function in the fetus, leading to anuria, renal failure, underdeveloped lungs, skeletal deformities, including skull hypoplasia, low blood pressure, and even death. Thiazides can cross the placenta, and the levels in the umbilical vein can be similar to those in your bloodstream. Taking thiazides during pregnancy is associated with a risk of jaundice or low platelet counts in your baby. These medications should not be used to treat high blood pressure in pregnant women. It is best to avoid using hydrochlorothiazide for other conditions during pregnancy. If you are nursing, please be advised that breastfeeding is not recommended while you are being treated with valsartan and hydrochlorothiazide. Side Effects You may experience a headache. Dizziness can occur. There is a chance of nasopharyngitis (2.4% vs. 1.9%). Be aware of potential fluid or electrolyte imbalance. This medication may cause exacerbation or activation of systemic lupus erythematosus. Acute angle-closure glaucoma is a possible side effect. Warnings when pregnancy is detected, discontinue valsartan and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume depletion prior to initiation observe for signs of fluid or electrolyte imbalance monitor renal function and potassium in susceptible patients exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma Pregnancy & Lactation valsartan and hydrochlorothiazide can cause fetal harm when administered to a pregnant woman use of drugs that act on the reninangiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death when pregnancy is detected discontinue valsartan and hydrochlorothiazide as soon as possible hypertension in pregnancy increases the maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death oligohydramnios in pregnant women who use drugs affecting the renin-angiotensin system in the second and third trimesters of pregnancy can result in reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension and death thiazides can cross the placenta, and concentrations reached in the umbilical vein approach those in the maternal plasma use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia these drugs should not be used to treat hypertension in pregnant women the use of hydrochlorothiazide for other indications in pregnancy should be avoided advise a nursing woman that breastfeeding is not recommended during treatment with valsartan and hydrochlorothiazide Side Effects headache dizziness nasopharyngitis (2.4% vs. 1.9%) fluid or electrolyte imbalance exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma
Valsartan and Hydrochlorothiazide Rx tablet, film coated Solco Healthcare US, LLC	Popularity – score 0 out of 100 (least-viewed drug)	7 warnings	0 pregnancy and lactation warnings	7 side effects	Trend: fell 23% over the year; peaks in May, Jul.
Valsartan and Hydrochlorothiazide® · First marketed 2015 · Label last revised June 14, 2023View full label details → Warnings If you find out you are pregnant, please stop taking valsartan and hydrochlorothiazide tablets as soon as possible. Medications that directly affect the renin-angiotensin system can harm the developing fetus, potentially leading to serious injury or death. Make sure to correct any volume depletion before starting treatment. Keep an eye out for any signs of fluid or electrolyte imbalance. Your healthcare provider should monitor your renal function and potassium levels if you are at risk. Be aware that this medication may worsen or trigger systemic lupus erythematosus. Watch for symptoms of acute angle-closure glaucoma. Pregnancy & Lactation Valsartan and hydrochlorothiazide tablets can cause harm to your fetus if you are pregnant. Using medications that affect the renin-angiotensin system during the second and third trimesters of pregnancy can reduce your baby's kidney function and increase the risk of complications for both you and your baby. If you find out you are pregnant, please stop taking valsartan and hydrochlorothiazide tablets as soon as possible. Thiazides can cross the placenta, and the levels in the umbilical vein can be similar to those in your bloodstream. Taking thiazides during pregnancy may increase the risk of jaundice or low platelet counts in your baby. These medications should not be used to treat high blood pressure in pregnant women. It's best to avoid using hydrochlorothiazide for other conditions while you are pregnant. There is limited information about whether valsartan and hydrochlorothiazide tablets pass into breast milk, their effects on a breastfeeding infant, or their impact on milk production. If you are nursing, it is advised that you do not breastfeed while being treated with valsartan and hydrochlorothiazide tablets. Side Effects You may experience a headache. Dizziness can occur. There is a chance of nasopharyngitis (2.4% vs. 1.9%). You might notice hypotension. Be aware of potential fluid or electrolyte imbalances. This medication may exacerbate or activate systemic lupus erythematosus. Acute angle-closure glaucoma is a possible side effect. Warnings when pregnancy is detected, discontinue valsartan and hydrochlorothiazide tablets as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus correct volume depletion prior to initiation observe for signs of fluid or electrolyte imbalance monitor renal function and potassium in susceptible patients exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma Pregnancy & Lactation No pregnancy & lactation warnings reported. Side Effects headache dizziness nasopharyngitis (2.4% vs. 1.9%) hypotension fluid or electrolyte imbalance exacerbation or activation of systemic lupus erythematosus acute angle-closure glaucoma
Vaseretic (enalapril maleate and hydrochlorothiazide) Rx tablet Bausch Health US, LLC	Popularity – score 0 out of 100 (least-viewed drug)	25 warnings	2 pregnancy and lactation warnings	102 side effects	Trend: fell 19% over 11 months; peak from May to Jul.
Vaseretic® · First marketed 1986 · Label last revised August 31, 2020View full label details → Warnings If you detect that you are pregnant, please discontinue VASERETIC as soon as possible. Be aware that drugs acting directly on the renin-angiotensin system can cause injury and death to a developing fetus. While excessive hypotension is rarely seen in uncomplicated hypertensive patients, it can occur with enalapril use in individuals who are severely salt/volume depleted, such as those treated vigorously with diuretics or patients on dialysis. Syncope has been reported in 1.3 percent of patients taking VASERETIC. In patients with severe congestive heart failure, excessive hypotension has been observed and may be linked to oliguria and/or progressive azotemia, and in rare cases, acute renal failure and/or death. If you have severe congestive heart failure, therapy should be started under very close medical supervision. You should be closely monitored for the first two weeks of treatment and whenever your dose of enalapril and/or diuretic is increased. Angioedema affecting the face, extremities, lips, tongue, glottis, and/or larynx has been reported in patients treated with angiotensin converting enzyme inhibitors, including enalapril. If you experience angioedema, VASERETIC should be promptly discontinued, and appropriate therapy and monitoring should be provided until complete and sustained resolution of signs and symptoms occurs. If you are receiving both an ACE inhibitor and an mTOR inhibitor, you may be at increased risk for angioedema. Intestinal angioedema has been reported in patients treated with ACE inhibitors. If you have a history of angioedema unrelated to ACE inhibitor therapy, you may be at increased risk of angioedema while receiving an ACE inhibitor. Periodic monitoring of your white blood cell counts should be considered if you have collagen vascular disease and renal disease due to the risk of agranulocytosis and neutropenia. If you develop jaundice or marked elevations of hepatic enzymes while taking an ACE inhibitor, you should discontinue the ACE inhibitor and seek appropriate medical follow-up. Thiazides should be used with caution if you have severe renal disease. Thiazides should also be used with caution if you have impaired hepatic function or progressive liver disease. Sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma. There is a possibility of exacerbation or activation of systemic lupus erythematosus. You should be cautious and report any lightheadedness, especially during the first few days of therapy. If you experience actual syncope, please discontinue the drug until you have consulted with your prescribing physician. Do not use salt substitutes containing potassium without consulting your physician. Promptly report any signs of infection, as they may indicate neutropenia. If you are a female of childbearing age, please be informed about the consequences of exposure to VASERETIC during pregnancy. You should report any pregnancies to your physician as soon as possible. If you are taking hydrochlorothiazide, protect your skin from the sun and undergo regular skin cancer screening. Pregnancy & Lactation Enalapril, enalaprilat, and hydrochlorothiazide can be found in human breast milk. You should decide whether to continue nursing or to stop taking VASERETIC, considering how important the medication is for your health. Side Effects You may experience dizziness (8.6 percent). You might have a headache (5.5 percent). Fatigue (3.9 percent) could occur. Coughing (3.5 percent) is another possible side effect. You may notice muscle cramps (2.7 percent). Nausea (2.5 percent) can happen. You might feel asthenia (2.4 percent). Orthostatic effects (2.3 percent) may be present. You could experience impotence (2.2 percent). Diarrhea (2.1 percent) is a potential side effect. Syncope may occur. You might feel chest pain. Abdominal pain could happen. Orthostatic hypotension may be experienced. You might notice palpitations. Tachycardia could occur. Vomiting is another possible side effect. Dyspepsia may happen. You might experience constipation. Flatulence could occur. You may notice a dry mouth. Insomnia is a potential side effect. You might feel nervousness. Paresthesia may occur. Somnolence could happen. You might experience vertigo. Pruritus may be present. You could develop a rash. Dyspnea might occur. Gout may happen. You might feel back pain. Arthralgia could occur. Diaphoresis may be experienced. You might notice a decreased libido. Tinnitus could happen. You may develop a urinary tract infection. Hypotension might occur. Angioedema may happen. Pulmonary embolism is a serious potential side effect. Myocardial infarction could occur. A cerebrovascular accident may happen. You might experience pulmonary edema. Atrial tachycardia could occur. Bradycardia may be experienced. Atrial fibrillation might happen. You could feel angina pectoris. Raynaud's phenomenon may occur. Ileus could happen. Pancreatitis is a potential side effect. Hepatic failure may occur. Hepatitis could happen. Melena might be experienced. You may notice anorexia. Glossitis could occur. Stomatitis may happen. You might experience a dry mouth. Depression could occur. You might feel confusion. Ataxia may be experienced. Peripheral neuropathy could happen. Dream abnormalities might occur. Renal failure is a serious potential side effect. Oliguria may happen. Renal dysfunction could occur. You might feel flank pain. Gynecomastia may occur. Pulmonary infiltrates could happen. Eosinophilic pneumonitis may be experienced. Bronchospasm could occur. Pneumonia might happen. Bronchitis may occur. You might experience rhinorrhea. A sore throat could happen. Hoarseness may be present. Asthma might occur. You could develop an upper respiratory infection. Exfoliative dermatitis may happen. Toxic epidermal necrolysis is a serious potential side effect. Stevens-Johnson syndrome could occur. Herpes zoster may happen. Erythema multiforme might occur. Urticaria could happen. Pemphigus may be experienced. Alopecia might occur. Flushing could happen. Photosensitivity may occur. You might experience blurred vision. Taste alteration could happen. Anosmia may occur. Conjunctivitis might happen. You may notice dry eyes. Tearing could occur. Anaphylactoid reactions are a serious potential side effect. Neutropenia may happen. Thrombocytopenia could occur. Bone marrow depression might be experienced. Hemolytic anemia may occur. You might feel muscle spasms. Restlessness could happen. Erythema multiforme may occur. Acute myopia might happen. Secondary angle-closure glaucoma is a serious potential side effect. Warnings when pregnancy is detected, discontinue VASERETIC as soon as possible drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus excessive hypotension was rarely seen in uncomplicated hypertensive patients but is a possible consequence of enalapril use in severely salt/volume depleted persons such as those treated vigorously with diuretics or patients on dialysis syncope has been reported in 1.3 percent of patients receiving VASERETIC in patients with severe congestive heart failure, excessive hypotension has been observed and may be associated with oliguria and/or progressive azotemia, and rarely with acute renal failure and/or death therapy should be started under very close medical supervision in patients with severe congestive heart failure patients should be followed closely for the first two weeks of treatment and whenever the dose of enalapril and/or diuretic is increased angioedema of the face, extremities, lips, tongue, glottis and/or larynx has been reported in patients treated with angiotensin converting enzyme inhibitors, including enalapril VASERETIC should be promptly discontinued and appropriate therapy and monitoring should be provided until complete and sustained resolution of signs and symptoms has occurred in cases of angioedema patients receiving coadministration of ACE inhibitor and mTOR inhibitor may be at increased risk for angioedema intestinal angioedema has been reported in patients treated with ACE inhibitors patients with a history of angioedema unrelated to ACE inhibitor therapy may be at increased risk of angioedema while receiving an ACE inhibitor periodic monitoring of white blood cell counts in patients with collagen vascular disease and renal disease should be considered due to the risk of agranulocytosis and neutropenia patients receiving ACE inhibitors who develop jaundice or marked elevations of hepatic enzymes should discontinue the ACE inhibitor and receive appropriate medical follow-up thiazides should be used with caution in severe renal disease thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma the possibility of exacerbation or activation of systemic lupus erythematosus has been reported patients should be cautioned to report lightheadedness especially during the first few days of therapy if actual syncope occurs, the patients should be told to discontinue the drug until they have consulted with the prescribing physician patients should be told not to use salt substitutes containing potassium without consulting their physician patients should be told to report promptly any indication of infection which may be a sign of neutropenia female patients of childbearing age should be told about the consequences of exposure to VASERETIC during pregnancy patients should be asked to report pregnancies to their physicians as soon as possible patients taking hydrochlorothiazide should protect skin from the sun and undergo regular skin cancer screening Pregnancy & Lactation enalapril, enalaprilat, and hydrochlorothiazide have been detected in human breast milk a decision should be made whether to discontinue nursing or to discontinue VASERETIC, taking into account the importance of the drug to the mother Side Effects dizziness (8.6 percent) headache (5.5 percent) fatigue (3.9 percent) cough (3.5 percent) muscle cramps (2.7 percent) nausea (2.5 percent) asthenia (2.4 percent) orthostatic effects (2.3 percent) impotence (2.2 percent) diarrhea (2.1 percent) syncope chest pain abdominal pain orthostatic hypotension palpitation tachycardia vomiting dyspepsia constipation flatulence dry mouth insomnia nervousness paresthesia somnolence vertigo pruritus rash dyspnea gout back pain arthralgia diaphoresis decreased libido tinnitus urinary tract infection hypotension angioedema pulmonary embolism myocardial infarction cerebrovascular accident pulmonary edema atrial tachycardia bradycardia atrial fibrillation angina pectoris Raynaud's phenomenon ileus pancreatitis hepatic failure hepatitis melena anorexia glossitis stomatitis dry mouth depression confusion ataxia peripheral neuropathy dream abnormality renal failure oliguria renal dysfunction flank pain gynecomastia pulmonary infiltrates eosinophilic pneumonitis bronchospasm pneumonia bronchitis rhinorrhea sore throat hoarseness asthma upper respiratory infection exfoliative dermatitis toxic epidermal necrolysis Stevens-Johnson syndrome herpes zoster erythema multiforme urticaria pemphigus alopecia flushing photosensitivity blurred vision taste alteration anosmia conjunctivitis dry eyes tearing anaphylactoid reactions neutropenia thrombocytopenia bone marrow depression hemolytic anemia muscle spasm restlessness erythema multiforme acute myopia secondary angle-closure glaucoma

Data Generation & Sources

This page was automatically generated and is maintained by the AllDrugs AI Data-Science Team. It was built from the FDA Structured Product Label (DailyMed) for products of class thiazide diuretic, retrieved January 14, 2026 by a validated AI data-extraction workflow. Complete dosage-form information for each product is available on its individual label page. Regulatory status, pharmacologic class (EPC), and mechanism of action (MoA) were cross-checked against the FDA Orange Book. No human clinician has reviewed this version.

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Last AI update: January 14, 2026

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Regulatory data notice: Information on this page is reproduced verbatim from FDA public databases (NSDE, Orange Book, Purple Book, DailyMed SPL). NDA/ANDA drugs are FDA-approved, BLA biologics are FDA-licensed. Inclusion alone does not guarantee current market availability or imply FDA endorsement.

Medical disclaimer: This AI-generated content is provided for educational purposes only and does not constitute medical advice. Always consult a licensed healthcare professional for diagnosis or treatment decisions.