ADD CONDITION
Panacur
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- Active ingredient
- Fenbendazole 222 mg/1 g
- Other brand names
- Defendazole (by Norbrook Laboratories Limited)
- Fenbendazole (by Amgis Lifescience Limited)
- Fenbendazole (by Letco Medical, Llc)
- Fenbenpro Purity and Precision Fenbendazole (by Hubihol, Uab)
- Fenbenpro Purity and Precision Fenbendazole (by Hubihol, Uab)
- Panacur (by Merck Sharp & Dohme Corp.)
- Panacur (by Merck Sharp & Dohme Corp.)
- Panacur (by Merck Sharp & Dohme Corp.)
- Panacur C Canine (by Merck Sharp & Dohme Corp.)
- Safe-Guard (by Merck Sharp & Dohme Corp.)
- Safe-Guard (by Merck Sharp & Dohme Corp.)
- Safe-Guard (by Merck Sharp & Dohme Corp.)
- Safe-Guard (by Merck Sharp & Dohme Corp.)
- Safe-Guard (by Merck Sharp & Dohme Corp.)
- Safe-Guard Aquasol (by Merck Sharp & Dohme Corp.)
- View full label-group details →
- Dosage form
- Granule
- Route
- Oral
- Prescription status
- Animal
- Pregnancy
- See Pregnancy Use Section
- Lactation
- See Lactation Use Section
- Marketed in the U.S.
- Since 1979
- Label revision date
- November 4, 2024
- Veterinary Document
- Prescribing information, PDF file
- Active ingredient
- Fenbendazole 222 mg/1 g
- Other brand names
- Defendazole (by Norbrook Laboratories Limited)
- Fenbendazole (by Amgis Lifescience Limited)
- Fenbendazole (by Letco Medical, Llc)
- Fenbenpro Purity and Precision Fenbendazole (by Hubihol, Uab)
- Fenbenpro Purity and Precision Fenbendazole (by Hubihol, Uab)
- Panacur (by Merck Sharp & Dohme Corp.)
- Panacur (by Merck Sharp & Dohme Corp.)
- Panacur (by Merck Sharp & Dohme Corp.)
- Panacur C Canine (by Merck Sharp & Dohme Corp.)
- Safe-Guard (by Merck Sharp & Dohme Corp.)
- Safe-Guard (by Merck Sharp & Dohme Corp.)
- Safe-Guard (by Merck Sharp & Dohme Corp.)
- Safe-Guard (by Merck Sharp & Dohme Corp.)
- Safe-Guard (by Merck Sharp & Dohme Corp.)
- Safe-Guard Aquasol (by Merck Sharp & Dohme Corp.)
- View full label-group details →
- Dosage form
- Granule
- Route
- Oral
- Prescription status
- Animal
- CSA schedule
- Not a scheduled drug
- Pregnancy
- See Pregnancy Use Section
- Lactation
- See Lactation Use Section
- Marketed in the U.S.
- Since 1979
- Label revision date
- November 4, 2024
- Manufacturer
- Merck Sharp & Dohme Corp.
- Registration number
- NADA121473
- NDC root
- 57926-474
- Veterinary Document
- Prescribing information, PDF file
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Drug Overview
Panacur® (fenbendazole) is a medication that contains the active ingredient fenbendazole, which is an anthelmintic (a type of drug used to treat parasitic worm infections). It is specifically formulated in granule form with a concentration of 22.2% fenbendazole, which helps in controlling various internal parasites.
This medication is primarily used for the treatment of internal parasites in certain wild animals, particularly members of the cat family (Felidae) such as lions, tigers, and cheetahs, as well as bears (Ursidae) like black bears and polar bears. Panacur® is effective against several types of worms, including ascarids, hookworms, and tapeworms, helping to maintain the health of these animals by managing parasitic infections.
Uses
This medication is designed to help control certain types of intestinal parasites in specific wild animal species, including big cats like lions, tigers, and leopards, as well as bears such as black bears and grizzly bears.
It effectively targets ascarids (a type of roundworm), including Toxocara cati and Toxascaris leonina, as well as hookworms like Ancylostoma spp. and Ancylostoma caninum. Additionally, it helps manage tapeworms, specifically Taenia hydatigena, T. krabbei, and T. taeniaeformis. If you are caring for these animals, this treatment can be an important part of their health management.
Dosage and Administration
When using Panacur Granules for Felidae (cats) and Ursidae (bears), you will need to give a daily dose of 10 mg for every kilogram of body weight for three consecutive days. To make this easier, you can calculate the amount needed based on your pet's weight. For example, if your pet weighs 22 kg (or 50 lbs), you would use 1 gram of the Panacur Granules, which contains 22.2% of the active ingredient.
To ensure accurate dosing, weigh your pet first, then determine the total amount of granules required. Remember, it's important to administer this medication daily for three days in a row to achieve the best results. Always consult with your veterinarian if you have any questions or concerns about the dosing process.
What to Avoid
There are no specific contraindications for this medication, meaning it is generally safe for most people to use. However, it's important to be aware that there are no details provided regarding its classification as a controlled substance, risks of abuse or misuse, or concerns about dependence (which refers to a condition where your body becomes reliant on a substance).
Since there are no explicit "do not take" or "do not use" instructions listed, it’s always best to consult with your healthcare provider before starting any new medication. They can provide personalized advice based on your health history and current medications.
Side Effects
In clinical studies involving 240 dogs, three experienced vomiting, which may be related to the medication. It's important to ensure that the medicated food is completely consumed for the treatment to be effective. While another medication in the same class has been linked to liver damage in dogs, this specific effect has not been observed with fenbendazole during its clinical use. There are no known contraindications for this medication.
Warnings and Precautions
It's important to remember that this medication is only to be used under the guidance of a licensed veterinarian, as federal law restricts its use. Additionally, you should avoid using this drug 14 days before or during the hunting season to ensure safety and effectiveness.
For the medication to work properly, make sure that your pet fully consumes the medicated food. Always check that the dispensing containers are clearly labeled with the drug identification and directions for use to avoid any confusion. While there are no specific lab tests required or emergency instructions provided, it's crucial to follow your veterinarian's advice closely for the best care of your pet.
Overdose
If you suspect an overdose of Panacur, it's important to be aware of potential signs and what steps to take. Some animals, like pumas and jaguars, have shown signs of inappetence (loss of appetite) after receiving doses ten times higher than recommended for longer than advised. Additionally, loose stools have been reported in various animals, including pumas and black bears, after similar overdoses.
If you notice any unusual behavior or symptoms in your pet, such as a lack of appetite or diarrhea, it’s crucial to contact your veterinarian immediately. They can provide guidance on the best course of action. Remember, while some studies have shown that even high doses of Panacur may not cause severe toxicity, it’s always better to err on the side of caution and seek professional help if you suspect an overdose.
Pregnancy Use
You may be wondering about the safety of using Panacur during pregnancy. Research has shown that Panacur has been given to pregnant and non-pregnant female animals, as well as male animals, at doses up to ten times higher than recommended and for twice the suggested treatment duration without any negative effects on reproduction. This suggests that Panacur is generally considered safe in these circumstances.
However, it's important to note that in a couple of cases involving a puma and a jaguar, administering ten times the recommended dose for an extended period did lead to some signs of inappetence (loss of appetite). While these findings are specific to animal studies, they highlight the importance of using medications as directed and consulting with your healthcare provider if you are pregnant or planning to become pregnant. Always prioritize your health and the health of your baby by discussing any medications with your doctor.
Lactation Use
If you are breastfeeding or planning to breastfeed, it's important to know that the drug insert for Panacur (fenbendazole) does not provide specific information or guidelines regarding its use during nursing. This means that there are no established recommendations or known effects on breast milk or nursing infants.
As always, it's best to consult with your healthcare provider before taking any medication while breastfeeding to ensure the safety of both you and your baby. They can help you weigh the benefits and risks based on your individual situation.
Pediatric Use
When considering the use of Panacur Granules 22.2% for your child, it's important to note that there is currently no information available on how this medication interacts with other nutritional or drug substances in cats (Felidae) and bears (Ursidae). This means you should be cautious and consult with a healthcare professional before combining it with other treatments.
Additionally, studies have shown that Panacur Granules 22.2% is safe for weaned puppies, even when given at doses five times higher than the recommended daily amount and for twice the usual treatment duration. However, always follow your healthcare provider's guidance regarding the appropriate dosage and duration for your child.
Geriatric Use
When it comes to using this medication in older adults, there is no specific information available about dosage adjustments, safety concerns, or special precautions. This means that if you or a loved one is an older adult considering this medication, it’s important to consult with a healthcare provider. They can help determine the best approach based on individual health needs and any other medications being taken. Always prioritize open communication with your healthcare team to ensure safe and effective treatment.
Renal Impairment
If you have kidney issues, it's important to know that there are currently no data supporting the use of Panacur Granules 22.2% alongside other nutritional or drug substances in cats (Felidae) and bears (Ursidae). This means you should avoid mixing it with other treatments unless advised by your veterinarian.
Additionally, for Panacur to work effectively, you must ensure that the medicated food is completely consumed. This is crucial for the medication to have the desired effect on your pet's health. Always consult with your veterinarian for personalized advice and monitoring based on your specific situation.
Hepatic Impairment
If you have liver problems, it's important to know that there are currently no specific studies on using Panacur Granules 22.2% alongside other nutritional or drug substances in cats and bears. However, based on practical experience, no incompatibilities have been observed when using Panacur.
While another similar medication has been linked to liver damage in dogs, there have been no reports of such effects with fenbendazole, the active ingredient in Panacur. Always consult your healthcare provider for personalized advice and monitoring if you have liver concerns.
Drug Interactions
It's important to talk to your healthcare provider about any medications or supplements you are taking, especially when considering Panacur Granules 22.2%. While there are no known incompatibilities with other drugs based on clinical experience, the specific effects of combining Panacur with other nutritional or drug substances in certain animal groups, like cats and bears, have not been studied.
In trials with dogs, Panacur has been safely given alongside various medications, including antibiotics and steroids, without any reported issues. However, since individual responses can vary, discussing your full list of medications with your healthcare provider ensures safe and effective treatment.
Storage and Handling
To ensure the safety and effectiveness of your product, store it at a controlled room temperature between 68-77°F (20-25°C). This helps maintain its quality. It's also important to keep this product, as well as all medications, out of the reach of children to prevent accidental ingestion or misuse.
When handling the product, always do so with clean hands and in a clean environment to avoid contamination. Following these guidelines will help you use the product safely and effectively.
Additional Information
You should take Panacur orally, and it's important to ensure that any medicated food is completely consumed for the medication to work effectively. When receiving this medication, make sure that the dispensing container is clearly labeled with the drug identification and directions for use to avoid any confusion.
FAQ
What is Panacur®?
Panacur® (fenbendazole) Granules 22.2% contains the active ingredient fenbendazole, which is an anthelmintic used to control internal parasites.
What species can be treated with Panacur®?
Panacur® is used for Felidae (e.g., lions, tigers, cheetahs) and Ursidae (e.g., black bears, polar bears, grizzly bears) to control various internal parasites.
What parasites does Panacur® target?
Panacur® is effective against ascarids, hookworms, and tapeworms in specified species of Felidae and Ursidae.
What is the recommended dosage for Panacur®?
The recommended dose is 10 mg/kg body weight daily for 3 consecutive days.
How should Panacur® be administered?
Panacur® should be mixed with a small portion of food or applied as a top dressing to ensure the animal fully consumes the medicated food.
Are there any known contraindications for Panacur®?
There are no known contraindications for Panacur®.
What are the potential side effects of Panacur®?
In clinical studies, some dogs experienced vomiting, which may have been related to the drug.
Can Panacur® be used in pregnant animals?
Yes, Panacur® has been administered to pregnant and non-pregnant females without adverse effects on reproduction.
What precautions should be taken when using Panacur®?
Ensure that the medicated food is fully consumed for Panacur® to be effective, and follow the dosing instructions carefully.
How should Panacur® be stored?
Store Panacur® at a controlled room temperature of 68-77°F (20-25°C) and keep it out of reach of children.
Packaging Info
The table below lists each NDC Code for Panacur (fenbendazole) veterinary formulations. Columns show Packaging, Formulation Type, and Active Ingredient Strength.
Details | ||||
|---|---|---|---|---|
| Granule | 222 mg/1 g | ||
Product details Regulatory status — Marketed All current FDA data sets list this NDC as actively marketed. FDA record dates for this NDC:
Active ingredients
| ||||
Drug Information (PDF)
This PDF provides official product information for Panacur, which is intended for animal use only.
Description
Panacur® (fenbendazole) Granules 22.2% is an anthelmintic formulation containing the active ingredient fenbendazole, which is chemically designated as methyl 5-(phenylthio)-2-benzimidazole carbamate. The product has a concentration of 222 mg of fenbendazole per gram. The CAS Registry Number for fenbendazole is 43210-67-9.
Uses and Indications
This drug is indicated for the control of gastrointestinal parasites in specific species of Felidae and Ursidae. It is effective against ascarids, including Toxocara cati, Toxascaris leonina, and Baylisascaris transfuga. Additionally, it provides control of hookworms, specifically Ancylostoma spp. and Ancylostoma caninum. The drug also targets tapeworms, including Taenia hydatigena, T. krabbei, and T. taeniaeformis.
This formulation is intended for use in lions, tigers, cheetahs, pumas, panthers, leopards, jaguars, black bears, polar bears, and grizzly bears. It is essential to follow the recommended usage instructions for optimal efficacy in the specified species.
Dosage and Administration
The recommended dosage for Felidae and Ursidae is 10 mg/kg of body weight, administered daily for a duration of 3 consecutive days. To achieve the daily dose of 10 mg/kg (equivalent to 4.54 mg/lb), healthcare professionals should weigh the animal and calculate the appropriate amount of Panacur Granules 22.2%. Specifically, 1 gram of the granules should be administered for every 22 kg (or 50 lbs) of body weight.
It is essential to ensure accurate dosing by weighing the animal prior to administration. The granules should be mixed with a small amount of food to facilitate ingestion, ensuring that the entire dose is consumed. Monitoring the animal's response to treatment during the administration period is advised.
Contraindications
There are no known contraindications for the use of this product.
Warnings and Precautions
CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. It is imperative that healthcare professionals adhere to this regulation to ensure the safe and effective use of the medication.
Healthcare providers should advise clients that the drug should not be used within 14 days prior to or during the hunting season. This precaution is essential to prevent any potential adverse effects that may arise during this period.
In terms of general precautions, it is critical that the medicated food is fully consumed by the animal for Panacur to achieve its intended therapeutic effect. Additionally, all dispensing containers must be clearly labeled with the drug identification and comprehensive directions for use to ensure proper administration and compliance.
Currently, there are no specific laboratory tests recommended for monitoring the use of this medication. However, healthcare professionals should remain vigilant and monitor the overall health and response of the patient to the treatment.
Side Effects
In US clinical studies involving 240 dogs, three participants experienced vomiting, which may have been related to the administration of the drug. This adverse reaction, while noted, was not widespread among the subjects.
It is important to ensure that the medicated food is fully consumed for Panacur® to achieve its intended effectiveness.
While there are no known contraindications associated with the use of this medication, it is noteworthy that another benzimidazole has been reported to cause hepatotoxicity in canines. However, this specific adverse effect has not been documented during the clinical use of fenbendazole.
Drug Interactions
Panacur Granules 22.2% has not been studied in conjunction with other nutritional and drug substances in Felidae and Ursidae, and currently, there are no data available to support such use. However, clinical experience has not indicated any incompatibilities when Panacur is used under actual conditions.
In canine clinical trials, Panacur Granules 22.2% has been administered alongside a diverse range of medications, including antibiotics, steroids, anesthetics, tranquilizers, vitamins, and minerals. At this time, no known incompatibilities with these drugs have been reported. Therefore, no specific dosage adjustments or enhanced monitoring protocols are necessary when Panacur is co-administered with these substances.
Packaging & NDC
The table below lists each NDC Code for Panacur (fenbendazole) veterinary formulations. Columns show Packaging, Formulation Type, and Active Ingredient Strength.
Details | ||||
|---|---|---|---|---|
| Granule | 222 mg/1 g | ||
Product details Regulatory status — Marketed All current FDA data sets list this NDC as actively marketed. FDA record dates for this NDC:
Active ingredients
| ||||
Pediatric Use
Pediatric patients have not been studied extensively with Panacur Granules 22.2% in conjunction with other nutritional and drug substances in Felidae and Ursidae. Therefore, there are currently no data available to support such use.
In studies involving weaned pups, Panacur Granules 22.2% demonstrated a favorable safety profile, as it did not cause toxicity when administered at doses up to 5 times the recommended daily dose and for 2 times the duration of treatment.
Geriatric Use
There is no specific information regarding the use of this medication in geriatric patients, including dosage adjustments, safety concerns, or special precautions. Healthcare providers should exercise caution when prescribing this medication to elderly patients, as they may have altered pharmacokinetics and pharmacodynamics. Close monitoring is recommended to ensure safety and efficacy in this population.
Pregnancy
Panacur has been evaluated in both pregnant and non-pregnant females, as well as male animals, including Felidae and Ursidae, at doses up to ten times the recommended amount for twice the recommended treatment duration. These studies did not demonstrate any adverse effects on reproduction. However, it is important to note that in one instance involving a puma and one involving a jaguar, administration of ten times the recommended dose for twice the recommended duration resulted in evidence of inappetence when Panacur Granules were given.
Given the available data, healthcare professionals should exercise caution when considering the use of Panacur in pregnant patients. While no significant reproductive toxicity has been observed in animal studies, the potential for adverse effects, such as inappetence, should be taken into account. Further studies may be warranted to fully understand the implications of Panacur use during pregnancy.
Lactation
There are no specific statements or information regarding nursing mothers or lactation considerations in the provided drug insert for Panacur (fenbendazole). Therefore, the effects on breastfed infants and the excretion of fenbendazole in breast milk remain undetermined. Healthcare professionals should exercise caution and consider the potential risks versus benefits when prescribing this medication to lactating mothers.
Renal Impairment
Patients with renal impairment should be aware that there are currently no data available to support the use of Panacur Granules 22.2% in conjunction with other nutritional and drug substances in Felidae and Ursidae. It is essential that medicated food is fully consumed for Panacur to be effective. Therefore, careful monitoring of dietary intake is recommended in patients with reduced kidney function to ensure therapeutic efficacy.
Hepatic Impairment
Patients with hepatic impairment should be monitored closely when considering the use of Panacur Granules 22.2%. Currently, there are no data available to support the use of this medication in conjunction with other nutritional and drug substances in Felidae and Ursidae. However, clinical experience has not revealed any incompatibilities with Panacur under actual conditions of use.
It is important to note that while another benzimidazole has been associated with hepatotoxicity in canines, such effects have not been reported during the clinical use of fenbendazole. Therefore, while no specific dosage adjustments are recommended for patients with compromised liver function, careful monitoring of liver function is advised to ensure patient safety.
Overdosage
In cases of overdosage with Panacur, the following observations and management considerations are pertinent.
Observations in Animal Studies Panacur has been administered to both pregnant and non-pregnant females, as well as male animals, including species from the Felidae and Ursidae families, at doses up to ten times the recommended level for twice the recommended treatment duration. Notably, these instances did not result in any adverse effects on reproduction.
However, specific cases have demonstrated potential symptoms of overdosage. In one puma and one jaguar, administration of ten times the recommended dose for twice the recommended duration resulted in periods of inappetence. Additionally, loose stools were reported in studies involving pumas, black bears, and ruminants, indicating gastrointestinal disturbances may occur at elevated doses.
Management Recommendations In the event of suspected overdosage, it is advisable to monitor the affected animal closely for signs of inappetence and gastrointestinal upset. While Panacur Granules 22.2% did not exhibit toxicity when administered to weaned pups at doses equal to five times the recommended daily dose for twice the duration of treatment, veterinary professionals should remain vigilant and consider supportive care as necessary.
Overall, while significant adverse effects have not been consistently observed at high doses, careful observation and management of symptoms are recommended to ensure the well-being of the animal.
Nonclinical Toxicology
Panacur has been evaluated in nonclinical studies involving both pregnant and non-pregnant females, as well as male animals, including species from the Felidae and Ursidae families. Administration of Panacur at ten times the recommended dose for twice the recommended treatment duration did not demonstrate any adverse effects on reproduction.
However, in individual cases involving a puma and a jaguar, administration of ten times the recommended dose for twice the recommended duration resulted in observable signs of inappetence.
Postmarketing Experience
Loose stools have been reported in pumas, black bears, and ruminants during studies conducted in a variety of captive animals. In addition, periods of inappetence were observed in one puma and one jaguar following the initial consumption of fenbendazole at ten times the recommended treatment level. While another benzimidazole has been associated with hepatotoxicity in canines, this effect has not been documented in the clinical use of fenbendazole. In US clinical studies, vomiting was reported in 3 out of 240 dogs, which may be related to the drug.
Patient Counseling
Healthcare providers should inform patients that federal law restricts the use of this drug to administration by or on the order of a licensed veterinarian. It is essential to emphasize the importance of administering the appropriate dose of Panacur. Patients should be advised that the granules may be best ingested by applying them as a top dressing or by mixing them with a small portion of food before offering the main meal.
Patients must be made aware that the medicated food must be fully consumed for Panacur to be effective. Additionally, healthcare providers should ensure that dispensing containers are labeled with the drug identification and clear directions for use.
It is crucial to remind patients to keep this and all medications out of the reach of children. Furthermore, patients should be instructed to store the medication at a controlled room temperature of 68-77°F (20-25°C) to maintain its efficacy.
Storage and Handling
The product is supplied in various package configurations, with specific NDC numbers available upon request. It should be stored at a controlled room temperature of 68-77°F (20-25°C) to maintain its efficacy. Additionally, it is imperative to keep this medication, along with all other medications, out of the reach of children to ensure safety.
Additional Clinical Information
The route of administration for the medication is oral. Clinicians should advise patients that the medicated food must be fully consumed for the medication to be effective. Additionally, dispensing containers should be clearly labeled with drug identification and directions for use. No further information is available regarding laboratory tests, abuse potential, or postmarketing experience.
Drug Information (PDF)
This document includes the full labeling information for Panacur, as submitted by Merck Sharp & Dohme Corp. for veterinary use. It may include dosage by species, withdrawal periods, and administration instructions.