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Game on

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Active ingredients
  • Menthol, Unspecified Form 91 mg/1 g
  • Methyl Salicylate 290 mg/1 g
Other brand names
Dosage form
Spray
Route
Topical
Prescription status
OTC (over the counter)
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 2025
Label revision date
August 20, 2025
Drug Information (PDF)
Prescribing information, PDF file
Active ingredients
  • Menthol, Unspecified Form 91 mg/1 g
  • Methyl Salicylate 290 mg/1 g
Other brand names
Dosage form
Spray
Route
Topical
Prescription status
OTC (over the counter)
CSA schedule
Not a scheduled drug
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 2025
Label revision date
August 20, 2025
Manufacturer
Natural Essentials, Inc.
Registration number
M017
NDC root
66902-378
Drug Information (PDF)
Prescribing information, PDF file
Packaging Info
Packaging & NDC Codes

If you are a healthcare professional or from the pharmaceutical industry please visit this version.

If you are a consumer or patient please visit this version.

Drug Overview

GAME ON XTREME is a warm-up spray designed to help relieve minor pain in muscles and joints. It can be particularly useful for conditions associated with arthritis, simple backaches, strains, bruises, and sprains. By applying this spray, you may find relief from discomfort, allowing you to stay active and engaged in your daily activities.

Dosage and Administration

Before using the medication, make sure to shake the bottle well. If you are an adult or a child aged 12 years or older, you can spray the product on the affected area up to 1 to 3 times each day.

If the user is a child under 12 years old, it’s important to consult a doctor before use to ensure safety and proper guidance. Always follow these instructions carefully to get the best results from your treatment.

Side Effects

When using this product, it's important to apply it only to unbroken skin and avoid contact with your eyes or mucous membranes. You should not use it on wounds or irritated skin, and be careful not to bandage tightly or use it with a heating pad. Always follow the directions provided and store it at temperatures below 120°F.

If your condition worsens, symptoms last more than seven days, or if they clear up and return shortly after, stop using the product and consult a doctor. Additionally, if you are pregnant or breastfeeding, please speak with a healthcare professional before use. Keep this product out of reach of children and pets, and seek immediate medical help if it is swallowed.

Overdose

If you or someone else has swallowed too much of a medication, it’s important to seek medical help immediately. You can do this by contacting a Poison Control Center or going to the nearest emergency room. Acting quickly can make a significant difference in the outcome.

Signs of an overdose can vary, but they may include unusual drowsiness, confusion, or difficulty breathing. If you notice any of these symptoms, don’t hesitate to get help right away. Remember, it’s always better to be safe and get checked by a medical professional.

Pregnancy Use

If you are pregnant or breastfeeding, it’s important to consult with a healthcare professional before using this medication. They can provide guidance on whether it’s safe for you and your baby. Always prioritize your health and the health of your child by seeking expert advice.

Lactation Use

If you are pregnant or breastfeeding, it’s important to consult with a healthcare professional before using any medication. This ensures that you understand any potential risks and can make informed decisions about your health and the health of your baby. Always prioritize open communication with your doctor regarding your breastfeeding journey.

Geriatric Use

When it comes to using this medication in older adults, there is no specific information available about dosage adjustments, safety concerns, or special precautions. This means that if you or a loved one is an older adult considering this medication, it’s important to consult with a healthcare provider. They can help determine the best approach based on individual health needs and any other medications being taken. Always prioritize open communication with your healthcare team to ensure safe and effective treatment.

Hepatic Impairment

If you have liver problems, it's important to know that the drug insert does not provide specific information about dosage adjustments, special monitoring, or precautions for your condition. This means that there are no tailored guidelines for how this medication should be used if you have hepatic impairment (liver issues).

Before starting any new medication, including this one, you should discuss your liver health with your healthcare provider. They can help determine the best approach for your treatment and ensure your safety.

Drug Interactions

It's great to know that there are no reported interactions between this medication and other drugs or laboratory tests. However, it's still very important to discuss all medications you are taking, including over-the-counter drugs and supplements, with your healthcare provider. This ensures that your treatment is safe and effective.

Always keep your healthcare provider informed about any changes in your health or new medications you may start. Open communication helps prevent any potential issues and supports your overall well-being.

Storage and Handling

When using this product, it's important to handle it with care to avoid any potential staining. Be cautious when spraying near fabrics and unprotected surfaces, as the product may leave marks. To ensure safety and effectiveness, always store the product in a cool, dry place, away from direct sunlight and extreme temperatures. Proper storage helps maintain its quality and performance.

If you have any leftover product, dispose of it according to local regulations to ensure safe and responsible handling.

Additional Information

No further information is available.

FAQ

What is GAME ON XTREME?

GAME ON XTREME is a warm-up spray designed to relieve minor pain in muscles and joints.

What conditions can GAME ON XTREME help relieve?

It can relieve minor pain associated with arthritis, simple backache, strains, bruises, and sprains.

How should I use GAME ON XTREME?

Shake well and spray the product on the affected area 1 to 3 times daily for adults and children 12 years and older. For children under 12, consult a doctor.

Are there any contraindications for using GAME ON XTREME?

No specific contraindications are mentioned, but do not apply it to wounds or damaged skin.

What precautions should I take when using GAME ON XTREME?

Keep it out of your eyes, do not bandage tightly, and do not use with a heating pad. Use only as directed.

What should I do if I experience worsening symptoms?

Stop using the product and consult a doctor if your condition worsens or if symptoms persist for more than 7 days.

Is GAME ON XTREME safe to use during pregnancy or breastfeeding?

If you are pregnant or breastfeeding, consult a health professional before use.

What should I do if GAME ON XTREME is swallowed?

Get medical help or contact a Poison Control Center immediately if swallowed.

Can GAME ON XTREME cause any staining?

Yes, it may cause staining, so use it with caution near fabric and unprotected surfaces.

Packaging Info

Below are the non-prescription pack sizes of Game on (menthol, methyl salicylate). Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Game on.
Details

Drug Information (PDF)

This file contains official product information for Game on, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Description

GAME ON XTREME is a warm-up spray designed for athletic use. The product is packaged in a net weight of 3.4 ounces (96 grams) and is filled and packaged in the USA.

Dosage and Administration

The product should be shaken well before use. For adults and children aged 12 years and older, the recommended administration is to spray the product on the affected area no more than 1 to 3 times daily. For children under 12 years of age, it is advised to consult a physician prior to use.

Contraindications

The product is contraindicated in the following situations:

Application to wounds or damaged, broken, or irritated skin is prohibited due to the potential for exacerbating the condition. Contact with eyes or mucous membranes must be avoided to prevent irritation or injury. Bandaging should not be tight, as this may restrict circulation. The use of heating pads in conjunction with the product is contraindicated, as it may lead to increased absorption and potential adverse effects. The product should only be used as directed to ensure safety and efficacy. Puncturing or incinerating the product is not permitted, and it should be stored at temperatures not exceeding 120°F to maintain stability and prevent degradation.

Side Effects

Patients should be aware that this product is for external use only. It is contraindicated for application to wounds or damaged, broken, or irritated skin. Care should be taken to avoid contact with the eyes and mucous membranes.

When using this product, patients are advised to keep it out of the eyes, avoid tight bandaging, and refrain from using it in conjunction with a heating pad. It is essential to use the product only as directed, and patients should not puncture or incinerate the container. Additionally, storage should be at temperatures not exceeding 120°F.

Patients are instructed to stop use and consult a doctor if their condition worsens, if symptoms persist for more than 7 days, or if symptoms clear up and then recur within a few days. The product should not be needed for longer than a week.

For pregnant or breastfeeding individuals, it is recommended to seek advice from a health professional prior to use. Furthermore, the product should be kept out of reach of children and pets. In the event of accidental ingestion, medical assistance should be sought immediately or contact with a Poison Control Center should be made.

Drug Interactions

No drug interactions have been identified in the available data. Additionally, there are no reported interactions between drugs and laboratory tests. Therefore, no dosage adjustments or monitoring recommendations are necessary based on drug interactions.

Packaging & NDC

Below are the non-prescription pack sizes of Game on (menthol, methyl salicylate). Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Game on.
Details

Geriatric Use

There is no specific information regarding the use of this medication in geriatric patients, including dosage adjustments, safety concerns, or special precautions. Healthcare providers should exercise caution when prescribing this medication to elderly patients, as individual responses may vary. Monitoring for potential adverse effects and therapeutic efficacy is recommended in this population.

Pregnancy

Pregnant patients and those who are breastfeeding should consult a healthcare professional prior to using this medication. It is important to assess the potential risks and benefits, as well as any available data regarding fetal outcomes and lactation. Healthcare providers should consider individual circumstances and the specific needs of the patient when making recommendations.

Lactation

Lactating mothers are advised to consult a health professional prior to using this medication. There is currently no available data regarding the excretion of this medication in human breast milk or its effects on breastfed infants. Therefore, caution is recommended when administering this medication to lactating individuals.

Hepatic Impairment

Patients with hepatic impairment have not been specifically studied in relation to this medication. Consequently, there are no established dosage adjustments, special monitoring requirements, or precautions outlined for individuals with compromised liver function. It is recommended that healthcare providers exercise caution when prescribing this medication to patients with hepatic impairment, given the lack of data on its safety and efficacy in this population. Regular monitoring of liver function may be prudent in these cases, although specific parameters are not defined in the prescribing information.

Overdosage

In the event of an overdosage, immediate medical assistance is crucial. If the substance is ingested, healthcare professionals should advise patients or caregivers to seek medical help or contact a Poison Control Center without delay.

Prompt intervention is essential to mitigate potential adverse effects associated with overdosage. Symptoms may vary depending on the specific substance involved, and healthcare providers should be prepared to assess and manage these symptoms accordingly.

Management procedures may include supportive care and symptomatic treatment, tailored to the individual patient's needs. Continuous monitoring and evaluation are recommended to ensure patient safety and effective resolution of any complications arising from the overdosage.

Nonclinical Toxicology

There are no teratogenic effects associated with the compound. Additionally, no non-teratogenic effects have been identified. The nonclinical toxicology data does not provide any further information regarding animal pharmacology and toxicology.

Postmarketing Experience

No postmarketing experience details are available in the insert.

Patient Counseling

Healthcare providers should advise patients to keep this product out of reach of children and pets to prevent accidental ingestion. Instruct patients that if the product is swallowed, they should seek medical help or contact a Poison Control Center immediately.

Patients should be informed not to apply the product to wounds or any damaged, broken, or irritated skin. It is also important to caution patients against allowing the product to come into contact with their eyes or mucous membranes.

Healthcare providers should encourage patients to stop using the product and consult a doctor if their condition worsens, if symptoms persist for more than 7 days, if symptoms clear up and then recur within a few days, or if the product is needed for longer than a week.

When using this product, patients should be reminded to keep it out of their eyes and to avoid bandaging the area tightly. They should not use the product in conjunction with a heating pad and must use it only as directed. Additionally, patients should be advised not to puncture or incinerate the product and to store it at temperatures not exceeding 120°F.

Storage and Handling

The product is supplied in configurations that may vary, and it is important to handle it with care due to its potential to cause staining. Caution is advised when spraying near fabric and unprotected surfaces to prevent any unwanted marks.

For optimal storage, the product should be kept in a cool, dry place, away from direct sunlight and extreme temperatures. It is recommended to store the product in its original container to maintain its integrity and effectiveness. Special handling precautions should be taken to avoid contact with sensitive materials and surfaces.

Additional Clinical Information

No further data are available.

Drug Information (PDF)

This file contains official product information for Game on, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Data Generation & Sources

This page was automatically generated and is maintained by the AllDrugs AI Data-Science Team. It was built from the FDA Structured Product Label (DailyMed) for Game on, retrieved by a validated AI data-extraction workflow.

All FDA-listed dosage forms and strengths are shown in the Packaging & NDC Codes section above. Regulatory status appears in the Summary Information panel above and was verified in the FDA National Drug Code directory and the NSDE NDC Directory daily file.

Note: an automated daemon monitors NSDE checksums; when the record for this NDC changes, the new file is pulled instantly and this page is refreshed.

No human clinician has reviewed this version.

Learn more in our Editorial Policy

Last AI update:

Primary FDA sources:

Orange Book data shown on this page are limited to Regulatory Status (Rx), Established Pharmacologic Class (EPC), and Mechanism of Action (MoA).

Regulatory data notice: Information on this page is reproduced verbatim from FDA public databases (NSDE, Orange Book, Purple Book, DailyMed SPL). NDA/ANDA drugs are FDA-approved, BLA biologics are FDA-licensed. Inclusion alone does not guarantee current market availability or imply FDA endorsement.

Medical disclaimer: This AI-generated content is provided for educational purposes only and does not constitute medical advice. Always consult a licensed healthcare professional for diagnosis or treatment decisions.