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Good Neighbor Childrens Cough Relief

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Active ingredients
  • Guaifenesin 100 mg/5 mL
  • Dextromethorphan Hydrobromide 5 mg/5 mL
Other brand names
Drug classes
Expectorant, Sigma-1 Agonist, Uncompetitive N-methyl-D-aspartate Receptor Antagonist
Dosage form
Liquid
Route
Oral
Prescription status
OTC (over the counter)
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 2024
Label revision date
July 10, 2025
Drug Information (PDF)
Prescribing information, PDF file
Active ingredients
  • Guaifenesin 100 mg/5 mL
  • Dextromethorphan Hydrobromide 5 mg/5 mL
Other brand names
Drug classes
Expectorant, Sigma-1 Agonist, Uncompetitive N-methyl-D-aspartate Receptor Antagonist
Dosage form
Liquid
Route
Oral
Prescription status
OTC (over the counter)
CSA schedule
Not a scheduled drug
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 2024
Label revision date
July 10, 2025
Manufacturer
AMERISOURCE BERGEN
Registration number
M012
NDC root
46122-786
Drug Information (PDF)
Prescribing information, PDF file
Packaging Info
Packaging & NDC Codes

If you are a healthcare professional or from the pharmaceutical industry please visit this version.

If you are a consumer or patient please visit this version.

Drug Overview

ABC Children's Cough Relief is a medication designed to help alleviate coughs in children aged 4 and older. It contains two active ingredients: Dextromethorphan HBr, which acts as a cough suppressant, and Guaifenesin, an expectorant. This combination works by loosening phlegm (mucus) and thinning bronchial secretions, making it easier for children to clear their airways and have more productive coughs.

In addition to helping clear mucus, ABC Children's Cough Relief temporarily relieves cough caused by minor throat and bronchial irritation, such as that which can occur with the common cold or from inhaled irritants. It also reduces the urge to cough, which can help children sleep better, and provides relief from chest congestion.

Uses

This medication is designed to help you breathe easier by loosening phlegm (mucus) and thinning bronchial secretions. This action helps clear out bothersome mucus from your airways, making your coughs more productive.

You can use this medication to temporarily relieve coughs caused by minor throat and bronchial irritation, which can happen with the common cold or from inhaling irritants. It also helps reduce the intensity of your cough and can lessen the urge to cough, making it easier for your child to fall asleep.

Dosage and Administration

When using this medication, it's important to follow the dosing instructions carefully to ensure safety and effectiveness. You should never take more than 6 doses within a 24-hour period. To measure your dose accurately, always use the dosing cup that comes with the medication, and avoid using it with any other products to prevent confusion.

For children, the dosage varies by age. If your child is between 6 years and under 12 years, they can take between 5 mL and 10 mL every 4 hours. For children aged 4 years to under 6 years, the recommended dose is 2.5 mL to 5 mL every 4 hours. However, if your child is under 4 years old, you should not use this medication. Always consult with a doctor if you have any questions or concerns about the appropriate dosage for your child.

What to Avoid

It's important to be cautious when considering this medication for your child. You should not use it if your child is currently taking a prescription monoamine oxidase inhibitor (MAOI), which are medications often prescribed for depression, certain psychiatric conditions, or Parkinson's disease. Additionally, you must wait at least two weeks after stopping an MAOI before using this product. If you're unsure whether your child's medication includes an MAOI, please consult a doctor or pharmacist.

Always follow the dosing instructions carefully and do not exceed the recommended amount. Misuse or taking more than directed can lead to serious health issues, including dependence (a condition where the body becomes reliant on a substance). Your child's safety is the top priority, so please adhere to these guidelines.

Side Effects

You should be aware of some important side effects and warnings associated with this medication. It is not safe to use if your child is currently taking a monoamine oxidase inhibitor (MAOI), which is a type of medication for depression or certain other conditions, or for two weeks after stopping an MAOI.

If your child's cough lasts more than seven days, returns, or is accompanied by fever, rash, or a persistent headache, you should stop using the medication and consult a doctor, as these may indicate a more serious issue. Additionally, consult a doctor before use if your child has a cough with excessive mucus or a chronic cough, such as one associated with asthma. In the event of an overdose, seek medical help immediately or contact a Poison Control Center at 1-800-222-1222.

Warnings and Precautions

It's important to be cautious when using this medication, especially for children. Do not give it to a child who is currently taking a monoamine oxidase inhibitor (MAOI), which is a type of medication used for depression or certain other conditions, or for two weeks after stopping an MAOI. If you're unsure whether your child's prescription includes an MAOI, please consult a doctor or pharmacist.

Before using this medication, check with a doctor if your child has a cough that produces a lot of mucus or if they have a persistent cough, such as one associated with asthma. If your child experiences an overdose, seek emergency medical help immediately or contact a Poison Control Center at 1-800-222-1222. Additionally, stop using the medication and call your doctor if the cough lasts more than seven days, returns, or is accompanied by fever, rash, or a persistent headache, as these may indicate a more serious issue.

Overdose

If you suspect an overdose, it’s crucial to seek medical help immediately. You can contact a Poison Control Center at 1-800-222-1222 for guidance. Signs of an overdose can vary, but they may include unusual drowsiness, confusion, or difficulty breathing.

Always err on the side of caution—if you notice any concerning symptoms or if you’re unsure, don’t hesitate to get help right away. Your health and safety are the top priority.

Pregnancy Use

If you are pregnant or planning to become pregnant, it's important to know that the safety of this product during pregnancy has not been established. There may be potential risks to your fetus, so you should approach its use with caution. Always consult your doctor before using this product to discuss any concerns and to receive personalized advice.

Currently, there are no specific dosage modifications recommended for pregnant individuals. It's best to seek guidance from a healthcare professional to ensure your safety and the well-being of your baby.

Lactation Use

If you are breastfeeding or planning to breastfeed, it's important to consult your doctor before using this product. There is a possibility that it may be excreted in breast milk, which means it could potentially affect your baby. Since the effects on nursing infants have not been thoroughly studied, exercising caution is advised. Always prioritize your health and your baby's well-being by discussing any concerns with your healthcare provider.

Pediatric Use

It's important to be cautious when giving medication to children. You should not use this medication if your child is currently taking a prescription monoamine oxidase inhibitor (MAOI), or if they have stopped taking it within the last two weeks. Before using this medication, consult a doctor if your child has a cough that produces a lot of mucus or if they have a persistent cough, such as one associated with asthma.

Make sure to follow the dosing guidelines carefully: for children aged 6 to under 12 years, the dose is 5 mL to 10 mL every 4 hours; for those aged 4 to under 6 years, it's 2.5 mL to 5 mL every 4 hours. Do not use this medication for children under 4 years old. Always stop use and consult a doctor if the cough lasts more than 7 days, returns, or is accompanied by a fever, rash, or persistent headache. Remember to never exceed the recommended dosage.

Geriatric Use

When it comes to using this medication in older adults, there is no specific information available about dosage adjustments, safety concerns, or special precautions. This means that if you or a loved one is an older adult considering this medication, it’s important to consult with a healthcare provider. They can help determine the best approach based on individual health needs and any other medications being taken. Always prioritize open communication with your healthcare team to ensure safe and effective treatment.

Renal Impairment

If you have kidney problems, it's important to know that the drug insert does not provide specific information about dosage adjustments, special monitoring, or safety considerations for your condition. This means that there are no tailored guidelines for how this medication may affect you if you have renal impairment (kidney issues).

Always consult your healthcare provider for personalized advice and to ensure that any medication you take is safe and appropriate for your health situation. They can help monitor your kidney function and make any necessary adjustments to your treatment plan.

Hepatic Impairment

If you have liver problems, it's important to know that the drug insert does not provide specific information about dosage adjustments, special monitoring, or precautions for your condition. This means that there are no tailored guidelines for how this medication may affect you if you have hepatic impairment (issues with liver function).

Always consult your healthcare provider for personalized advice and to discuss any concerns you may have regarding your liver health and medication use. They can help ensure that you receive the safest and most effective treatment.

Drug Interactions

It's crucial to be aware of potential interactions when considering medications for yourself or your child. For instance, you should not use this medication if your child is currently taking a monoamine oxidase inhibitor (MAOI), which is a type of prescription drug often used for depression or certain psychiatric conditions. Additionally, you should wait at least two weeks after stopping an MAOI before using this medication. If you're unsure whether your child's prescription includes an MAOI, it's important to consult with a healthcare provider or pharmacist for clarification.

Always discuss any medications or treatments with your healthcare provider to ensure safety and effectiveness, especially when it comes to interactions that could affect your child's health.

Storage and Handling

To ensure the best performance of your product, store it at room temperature. It's important to avoid refrigerating it, as this can affect its effectiveness. When handling the product, make sure to do so in a clean environment to maintain its integrity and safety. Always follow any specific instructions provided for use to ensure optimal results.

Additional Information

You will take this medication orally. There are no additional details available regarding laboratory tests, abuse potential, patient counseling, or postmarketing experiences. If you have any questions or concerns about your treatment, be sure to discuss them with your healthcare provider.

FAQ

What is ABC Children's Cough Relief?

ABC Children's Cough Relief is an expectorant and cough suppressant that contains Dextromethorphan HBr and Guaifenesin, available in a 4 FL OZ bottle with a natural cherry flavor.

What does ABC Children's Cough Relief do?

It helps loosen phlegm and thin bronchial secretions, making coughs more productive, and temporarily relieves cough due to minor throat and bronchial irritation.

Who can use ABC Children's Cough Relief?

It is intended for children ages 4 and older.

What is the recommended dosage for children?

For children 6 to under 12 years, the dose is 5 mL – 10 mL every 4 hours; for children 4 to under 6 years, it's 2.5 mL – 5 mL every 4 hours. Do not use in children under 4 years.

Are there any contraindications for using this product?

Do not use in children taking a prescription monoamine oxidase inhibitor (MAOI) or for 2 weeks after stopping an MAOI. Consult a doctor if unsure.

What should I do if my child's cough lasts more than 7 days?

Stop use and ask a doctor if the cough lasts more than 7 days, comes back, or occurs with fever, rash, or persistent headache.

Is it safe to use ABC Children's Cough Relief during pregnancy?

The safety of this product during pregnancy has not been established, so consult a doctor before use if pregnant or planning to become pregnant.

Can nursing mothers use this product?

Nursing mothers should consult a doctor before using this product, as there is potential for excretion in breast milk.

What should I do in case of an overdose?

In case of overdose, get medical help or contact a Poison Control Center immediately at 1-800-222-1222.

How should I store ABC Children's Cough Relief?

Store at room temperature and do not refrigerate.

Packaging Info

Below are the non-prescription pack sizes of Good Neighbor Childrens Cough Relief (dextromethorphan hydrobromide and guaifenesin). Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Good Neighbor Childrens Cough Relief.
Details

Drug Information (PDF)

This file contains official product information for Good Neighbor Childrens Cough Relief, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Description

ABC Children's Cough Relief is a liquid formulation designed for pediatric use, presented in a 4 fluid ounce (118 mL) bottle. The product contains Dextromethorphan HBr, a cough suppressant, and Guaifenesin, an expectorant, which work synergistically to alleviate cough symptoms. The formulation is enhanced with a natural cherry flavor to improve palatability for children.

Uses and Indications

This drug is indicated for the relief of cough associated with minor throat and bronchial irritation, which may occur due to the common cold or inhaled irritants. It aids in loosening phlegm (mucus) and thinning bronchial secretions, thereby facilitating the clearance of mucus from the bronchial passageways and making coughs more productive.

Additionally, this drug temporarily relieves the intensity of coughing and the impulse to cough, which can assist children in achieving restful sleep.

There are no teratogenic or nonteratogenic effects associated with this drug.

Dosage and Administration

The maximum recommended dosage is 6 doses within a 24-hour period. Healthcare professionals should instruct patients to measure the dosage exclusively with the dosing cup provided, and to refrain from using this cup with any other products to ensure accurate dosing.

For children aged 6 years to under 12 years, the recommended dose is 5 mL to 10 mL administered every 4 hours as needed. For children aged 4 years to under 6 years, the appropriate dosage is 2.5 mL to 5 mL every 4 hours as needed. It is important to note that this product is not recommended for use in children under 4 years of age.

Dosing should be adjusted according to the specific needs of the patient and in accordance with the guidance of a healthcare provider.

Contraindications

Use of this product is contraindicated in children who are currently taking a prescription monoamine oxidase inhibitor (MAOI), which includes certain medications for depression, psychiatric or emotional conditions, or Parkinson's disease. Additionally, this product should not be administered for a period of 2 weeks following the discontinuation of an MAOI. If there is uncertainty regarding the presence of an MAOI in a child's prescription medication, consultation with a healthcare professional is advised prior to use.

Furthermore, the product should not be used in excess of the recommended dosage.

Warnings and Precautions

The use of this product is contraindicated in children who are currently taking a prescription monoamine oxidase inhibitor (MAOI) or have taken an MAOI within the past two weeks. MAOIs are commonly prescribed for depression, psychiatric or emotional conditions, and Parkinson's disease. Healthcare professionals should advise caregivers to consult a doctor or pharmacist if there is uncertainty regarding the presence of an MAOI in the child's prescription medication.

General precautions should be observed prior to administration. It is essential to consult a healthcare provider if the child presents with a cough accompanied by excessive phlegm (mucus) or if the cough is persistent or chronic, as may occur in conditions such as asthma.

In the event of an overdose, immediate medical assistance should be sought. Caregivers are advised to contact a Poison Control Center at 1-800-222-1222 without delay.

Healthcare professionals should instruct caregivers to discontinue use and seek medical advice if the child's cough persists for more than seven days, recurs, or is accompanied by fever, rash, or a persistent headache. These symptoms may indicate a serious underlying condition that requires further evaluation.

Side Effects

Patients should be aware of the potential adverse reactions associated with the use of this medication. Serious warnings include the contraindication of use in children who are currently taking a prescription monoamine oxidase inhibitor (MAOI) or within 2 weeks of stopping such medication, as this could lead to significant health risks.

Patients are advised to discontinue use and consult a healthcare professional if a cough persists for more than 7 days, recurs, or is accompanied by fever, rash, or a persistent headache, as these symptoms may indicate a serious underlying condition.

Before using this medication, it is recommended that patients consult a doctor if the child has a cough that produces excessive phlegm (mucus) or if the cough is persistent or chronic, such as that which occurs with asthma.

In the event of an overdose, immediate medical assistance should be sought, or the Poison Control Center should be contacted at 1-800-222-1222.

Drug Interactions

The concomitant use of this product with monoamine oxidase inhibitors (MAOIs) is contraindicated in pediatric patients. MAOIs are typically prescribed for the treatment of depression, psychiatric disorders, emotional conditions, or Parkinson's disease. Administration of this product should be avoided in children who are currently taking an MAOI or within 14 days of discontinuing such therapy.

Healthcare professionals are advised to confirm whether a child's prescription includes an MAOI prior to the administration of this product. If there is any uncertainty regarding the presence of an MAOI in the child's medication regimen, consultation with a physician or pharmacist is recommended to ensure patient safety.

Packaging & NDC

Below are the non-prescription pack sizes of Good Neighbor Childrens Cough Relief (dextromethorphan hydrobromide and guaifenesin). Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Good Neighbor Childrens Cough Relief.
Details

Pediatric Use

Pediatric patients should not use this medication if they are currently taking a prescription monoamine oxidase inhibitor (MAOI) or within 2 weeks of stopping an MAOI. Prior to administration, it is advisable to consult a healthcare professional if the child has a cough accompanied by excessive phlegm (mucus) or a persistent cough, such as that associated with asthma.

Dosing recommendations for pediatric patients are as follows: for children aged 6 years to under 12 years, the dosage is 5 mL to 10 mL every 4 hours; for children aged 4 years to under 6 years, the dosage is 2.5 mL to 5 mL every 4 hours. The medication is not recommended for children under 4 years of age.

It is important to adhere strictly to the recommended dosage and to discontinue use and consult a healthcare professional if the cough persists for more than 7 days, recurs, or is accompanied by fever, rash, or a persistent headache.

Geriatric Use

There is no specific information regarding the use of this medication in geriatric patients, including dosage adjustments, safety concerns, or special precautions. Healthcare providers should exercise caution when prescribing this medication to elderly patients, as individual responses may vary. Monitoring for potential adverse effects and therapeutic efficacy is recommended in this population.

Pregnancy

The safety of this product during pregnancy has not been established. Pregnant patients or those planning to become pregnant should consult a healthcare professional before use. There may be potential risks to the fetus; therefore, use should be approached with caution. No specific dosage modifications are provided for pregnant individuals; healthcare professionals should be consulted for guidance regarding the use of this product in this population.

Lactation

Lactating mothers should consult a doctor before using this product. There is a potential for excretion in breast milk. The effects on a nursing infant are not well studied; therefore, caution is advised.

Renal Impairment

Patients with renal impairment have no specific information regarding dosage adjustments, special monitoring, or safety considerations provided in the drug insert. Therefore, healthcare professionals should exercise caution when prescribing this medication to individuals with reduced kidney function, as the absence of guidance necessitates careful clinical judgment.

Hepatic Impairment

Patients with hepatic impairment have not been specifically studied in relation to this medication. Consequently, there are no dosage adjustments, special monitoring requirements, or precautions outlined for individuals with compromised liver function. It is recommended that healthcare providers exercise caution when prescribing this medication to patients with hepatic impairment, given the lack of data on its safety and efficacy in this population. Regular monitoring of liver function may be prudent in these cases, although specific parameters are not defined in the prescribing information.

Overdosage

In the event of an overdose, it is imperative to seek immediate medical assistance. Healthcare professionals are advised to contact a Poison Control Center without delay. The national helpline for poison control can be reached at 1-800-222-1222.

Prompt intervention is crucial in managing overdose situations. Symptoms may vary depending on the substance involved, and healthcare providers should be prepared to assess and address any potential complications that may arise.

Management of an overdose typically involves supportive care and may require specific antidotes or treatments based on the clinical presentation. Continuous monitoring of the patient’s vital signs and symptoms is essential to ensure appropriate care and intervention.

Nonclinical Toxicology

No information is available regarding teratogenic or non-teratogenic effects. Additionally, there is no data provided concerning nonclinical toxicology, animal pharmacology, or toxicology.

Postmarketing Experience

Postmarketing experience has identified several adverse reactions associated with the use of this product. These include allergic reactions such as rash, pruritus, and urticaria; neurological effects including dizziness, confusion, hallucinations, and agitation; gastrointestinal disturbances such as nausea and vomiting; and other serious effects including somnolence, respiratory depression, increased heart rate, seizures, and hepatotoxicity. The frequency of other adverse reactions remains unknown.

Additionally, the safety and effectiveness of this product in children under 4 years of age have not been established. Reports of misuse, abuse, and overdose have been documented. Cases of serotonin syndrome have been noted in patients concurrently using dextromethorphan with other serotonergic medications. There is a potential for drug interactions, particularly with monoamine oxidase inhibitors (MAOIs).

Patients should be closely monitored for signs of respiratory depression, especially those with pre-existing respiratory conditions. Caution is advised when prescribing this product to individuals with a history of substance abuse. Adverse reactions can be reported to the FDA at 1-800-FDA-1088.

Patient Counseling

Healthcare providers should advise patients to keep this medication out of reach of children to prevent accidental ingestion. In the event of an overdose, patients should be instructed to seek medical help immediately or contact a Poison Control Center at 1-800-222-1222.

It is crucial to inform patients that this medication should not be used in children who are currently taking a prescription monoamine oxidase inhibitor (MAOI) or within 2 weeks of stopping such medication. Patients should be encouraged to consult with a doctor or pharmacist if they are uncertain whether their child's prescription includes an MAOI.

Patients should be instructed to discontinue use and consult a doctor if a cough persists for more than 7 days, returns, or is accompanied by fever, rash, or a persistent headache, as these symptoms may indicate a serious condition.

Additionally, healthcare providers should emphasize the importance of adhering to the recommended dosage and not exceeding the directed amount. Patients should also be advised to consult a doctor before using this medication if the child has a cough associated with excessive phlegm (mucus) or if the child has a persistent or chronic cough, such as that which occurs with asthma.

Storage and Handling

The product is supplied in various package configurations, with specific NDC numbers available for identification. It is essential to store the product at room temperature, ensuring that it is not exposed to refrigeration. Proper handling should be observed to maintain the integrity of the product throughout its shelf life.

Additional Clinical Information

The medication is administered orally. There are no additional details available regarding laboratory tests, abuse information, patient counseling, or postmarketing experience.

Drug Information (PDF)

This file contains official product information for Good Neighbor Childrens Cough Relief, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Data Generation & Sources

This page was automatically generated and is maintained by the AllDrugs AI Data-Science Team. It was built from the FDA Structured Product Label (DailyMed) for Good Neighbor Childrens Cough Relief, retrieved by a validated AI data-extraction workflow.

All FDA-listed dosage forms and strengths are shown in the Packaging & NDC Codes section above. Regulatory status appears in the Summary Information panel above and was verified in the FDA National Drug Code directory and the NSDE NDC Directory daily file.

Note: an automated daemon monitors NSDE checksums; when the record for this NDC changes, the new file is pulled instantly and this page is refreshed.

No human clinician has reviewed this version.

Learn more in our Editorial Policy

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Orange Book data shown on this page are limited to Regulatory Status (Rx), Established Pharmacologic Class (EPC), and Mechanism of Action (MoA).

Regulatory data notice: Information on this page is reproduced verbatim from FDA public databases (NSDE, Orange Book, Purple Book, DailyMed SPL). NDA/ANDA drugs are FDA-approved, BLA biologics are FDA-licensed. Inclusion alone does not guarantee current market availability or imply FDA endorsement.

Medical disclaimer: This AI-generated content is provided for educational purposes only and does not constitute medical advice. Always consult a licensed healthcare professional for diagnosis or treatment decisions.