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Hydrocortisone

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Active ingredient
Hydrocortisone 10 mg/1 g
Other brand names
Drug class
Corticosteroid
Dosage form
Cream
Route
Topical
Prescription status
OTC (over the counter)
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 2013
Label revision date
September 9, 2025
Drug Information (PDF)
Prescribing information, PDF file
Active ingredient
Hydrocortisone 10 mg/1 g
Other brand names
Drug class
Corticosteroid
Dosage form
Cream
Route
Topical
Prescription status
OTC (over the counter)
CSA schedule
Not a scheduled drug
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 2013
Label revision date
September 9, 2025
Manufacturer
Unifirst First Aid Corporation
Registration number
M017
NDC root
47682-933
Drug Information (PDF)
Prescribing information, PDF file
Packaging Info
Packaging & NDC Codes

If you are a healthcare professional or from the pharmaceutical industry please visit this version.

If you are a consumer or patient please visit this version.

Drug Overview

Medi-First Plus Hydrocortisone is a topical cream that contains 1% hydrocortisone, a medication commonly used to provide temporary relief from itching caused by minor skin irritations, inflammation, and rashes. This cream works by reducing inflammation and soothing the affected area, helping you feel more comfortable.

While it is effective for these purposes, it's important to use this product as directed and consult a doctor for any other uses.

Uses

You can use this product for the temporary relief of itching caused by minor skin irritations, inflammation, and rashes. It's important to note that if you have other uses in mind, you should consult with your doctor for advice and supervision.

Rest assured, there are no known teratogenic effects (which means it doesn't cause birth defects) associated with this product, making it a safer option for those concerned about such risks.

Dosage and Administration

If you are an adult or a child aged 2 years and older, you can apply the medication to the affected area up to 3 to 4 times a day. Make sure to follow this guideline to ensure the best results.

However, if your child is under 2 years old, it’s important not to use this medication without first consulting a doctor. Always prioritize safety and seek professional advice when it comes to younger children.

What to Avoid

It's important to use this medication safely. You should not use it for treating diaper rash; instead, consult your doctor for appropriate advice. Additionally, avoid contact with your eyes, as this can cause irritation. If you're considering using any other hydrocortisone product, make sure to talk to your doctor first to ensure it's safe for you.

Side Effects

When using this product, it's important to remember that it is for external use only. Avoid getting it in your eyes, and do not use it for diaper rash without consulting a doctor. If your condition worsens, if symptoms last longer than 7 days, or if symptoms improve and then return within a few days, stop using the product and talk to your doctor.

Keep this product out of reach of children. If it is swallowed, seek medical help or contact a Poison Control Center immediately.

Warnings and Precautions

This product is for external use only, so please avoid applying it to any areas that may come into contact with your eyes. If you are considering using any other hydrocortisone product, it's important to consult your doctor first to ensure it's safe for you.

You should stop using this product and contact your doctor if your condition worsens, if your symptoms last longer than 7 days, or if your symptoms improve and then return within a few days. If you accidentally swallow the product, seek emergency medical help or contact a Poison Control Center immediately.

Overdose

If you or someone else has swallowed too much of a medication, it’s important to seek medical help immediately. You can do this by contacting a Poison Control Center or going to the nearest emergency room. Acting quickly can make a significant difference in the outcome.

Signs of an overdose can vary, but they may include unusual drowsiness, confusion, or difficulty breathing. If you notice any of these symptoms, don’t hesitate to get help right away. Remember, it’s always better to be safe and seek assistance if you suspect an overdose.

Pregnancy Use

When it comes to using Hydrocortisone cream during pregnancy, there is currently no specific information available about its safety, dosage adjustments, or any special precautions you should take. This means that the effects of this medication on you and your developing baby are not well-studied or documented.

If you are pregnant or planning to become pregnant, it’s important to discuss any medications you are considering with your healthcare provider. They can help you weigh the potential benefits and risks based on your individual situation. Always prioritize open communication with your doctor to ensure the best care for you and your baby.

Lactation Use

If you are breastfeeding, it's important to talk to your doctor before using this product. Currently, there is no specific information available about whether hydrocortisone cream can pass into breast milk or what risks it may pose to your baby. Consulting with your healthcare provider will help ensure that you make the safest choice for both you and your infant.

Pediatric Use

If your child is under 2 years old, it's important not to use this medication without first consulting a doctor. For children aged 2 years and older, you can apply the medication to the affected area, but make sure to do so no more than 3 to 4 times a day. Always follow these guidelines to ensure your child's safety and well-being.

Geriatric Use

When it comes to using this medication in older adults, there is no specific information available about dosage adjustments, safety concerns, or special precautions. This means that if you or a loved one is an older adult considering this medication, it’s important to consult with a healthcare provider. They can help determine the best approach based on individual health needs and any other medications being taken. Always prioritize open communication with your healthcare team to ensure safe and effective treatment.

Renal Impairment

If you have kidney problems, it's important to know that the drug insert does not provide specific information about dosage adjustments, special monitoring, or safety considerations for your condition. This means that there are no tailored guidelines for how this medication may affect you if your kidneys are not functioning properly.

Always consult your healthcare provider for personalized advice and to ensure that any medication you take is safe and appropriate for your kidney health. They can help monitor your condition and make any necessary adjustments to your treatment plan.

Hepatic Impairment

If you have liver problems, it's important to know that the drug insert does not provide specific information about dosage adjustments, special monitoring, or precautions for your condition. This means that there are no tailored guidelines for how this medication may affect you if you have hepatic impairment (liver issues).

Always consult your healthcare provider for personalized advice and to discuss any concerns regarding your liver health and how it may relate to your treatment. They can help ensure that you receive the safest and most effective care.

Drug Interactions

It's important to have open conversations with your healthcare provider about any medications or tests you may be taking. Currently, there are no specific drug interactions or laboratory test interactions noted for this medication. However, every individual’s health situation is unique, and your healthcare provider can help ensure that your treatment plan is safe and effective for you. Always feel free to ask questions and share all the medications and supplements you are using.

Storage and Handling

To ensure the best performance and safety of your product, store it at room temperature and avoid freezing. It's important to keep the product in its original packaging and only use packets that are unopened and undamaged. If you find any packets that are opened or torn, do not use them, as this could compromise the product's integrity.

By following these simple storage and handling guidelines, you can help maintain the quality and effectiveness of the product.

Additional Information

You should apply this topical medication to the affected area no more than 3 to 4 times daily if you are an adult or a child aged 2 years and older. If your child is under 2 years old, consult a doctor before use. Always keep this product out of reach of children, and if swallowed, seek medical help or contact a Poison Control Center immediately.

While using this medication, avoid getting it in your eyes. Do not start using any other hydrocortisone product without first consulting your doctor. If your condition worsens, symptoms last more than 7 days, or if symptoms improve and then return within a few days, stop using the product and talk to your doctor. If you experience a serious side effect, you can report it by calling 800-634-7680.

FAQ

What is Medi-First Plus Hydrocortisone used for?

Medi-First Plus Hydrocortisone is used for the temporary relief of itching associated with minor skin irritations, inflammation, and rashes.

How should I use Medi-First Plus Hydrocortisone?

Apply to the affected area not more than 3 to 4 times daily for adults and children 2 years of age and over. Do not use in children under 2 years of age without consulting a doctor.

Are there any contraindications for using this product?

Do not use Medi-First Plus Hydrocortisone for the treatment of diaper rash. Consult a doctor for other uses.

What should I do if I experience side effects?

Stop use and ask a doctor if your condition worsens, symptoms persist for more than 7 days, or if symptoms clear up and occur again within a few days.

Is it safe to use this product during pregnancy?

There is no specific information regarding the safety of using Medi-First Plus Hydrocortisone during pregnancy. Consult your doctor for advice.

What precautions should I take when using this product?

Avoid contact with the eyes and do not begin use of any other hydrocortisone product unless you've consulted a doctor.

What should I do if the product is swallowed?

If swallowed, get medical help or contact a Poison Control Center right away.

How should I store Medi-First Plus Hydrocortisone?

Store at room temperature and do not freeze. Ensure the packaging is not opened or torn before use.

Packaging Info

Below are the non-prescription pack sizes of Hydrocortisone. Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Hydrocortisone.
Details

Drug Information (PDF)

This file contains official product information for Hydrocortisone, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Description

No description information is available for the specified drug.

Uses and Indications

This drug is indicated for the temporary relief of itching associated with minor skin irritations, inflammation, and rashes.

Other uses of this product should be undertaken only under the advice and supervision of a healthcare professional.

There are no teratogenic or nonteratogenic effects associated with this drug.

Dosage and Administration

For adults and children aged 2 years and older, the recommended application is to the affected area not more than 3 to 4 times daily. It is important to ensure that the application is limited to the specified frequency to avoid potential adverse effects.

For children under 2 years of age, the product should not be used without consulting a healthcare professional. It is essential to seek medical advice before administering this treatment to this age group.

Contraindications

The product is contraindicated for the treatment of diaper rash; consultation with a healthcare professional is advised in such cases.

Contact with the eyes should be avoided to prevent irritation or injury. Additionally, the initiation of any other hydrocortisone product should only occur after consulting a healthcare provider to ensure safety and appropriateness of treatment.

Warnings and Precautions

For external use only. Healthcare professionals should advise patients to avoid contact with the eyes during application. It is imperative that patients do not initiate the use of any other hydrocortisone product without prior consultation with a healthcare provider to prevent potential adverse effects or interactions.

Patients should be instructed to discontinue use and seek medical advice if any of the following occur: the condition worsens, symptoms persist beyond 7 days, or if symptoms resolve and then reappear within a few days. These actions are crucial to ensure appropriate management of the patient's condition.

In the event of accidental ingestion, immediate medical assistance should be sought, or the patient should contact a Poison Control Center without delay. Prompt action is essential to mitigate any potential health risks associated with ingestion.

Side Effects

Patients using this product should be aware that it is intended for external use only. It is contraindicated for the treatment of diaper rash, and individuals should consult a doctor before use in such cases.

During the use of this product, patients are advised to avoid contact with the eyes. Additionally, it is recommended that patients do not initiate the use of any other hydrocortisone product without prior consultation with a healthcare professional.

Patients should discontinue use and seek medical advice if their condition worsens, if symptoms persist for more than 7 days, or if symptoms resolve and then recur within a few days.

This product should be kept out of reach of children. In the event of accidental ingestion, patients should seek medical assistance or contact a Poison Control Center immediately.

Drug Interactions

There are currently no documented drug interactions associated with the use of this medication. Additionally, there is no information available regarding interactions with laboratory tests. As such, no specific recommendations for dosage adjustments or monitoring are warranted at this time.

Packaging & NDC

Below are the non-prescription pack sizes of Hydrocortisone. Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Hydrocortisone.
Details

Pediatric Use

Pediatric patients under 2 years of age should not use this medication; consultation with a healthcare professional is advised. For children aged 2 years and older, the recommended application is to the affected area no more than 3 to 4 times daily.

Geriatric Use

There is no specific information available regarding the use of this medication in geriatric patients, including dosage adjustments, safety concerns, or special precautions. Healthcare providers should exercise caution when prescribing this medication to elderly patients, as individual responses may vary. It is advisable to monitor these patients closely for any adverse effects or changes in efficacy, given the lack of targeted data for this population.

Pregnancy

There is no specific information available regarding the use of Hydrocortisone cream during pregnancy, including safety concerns, dosage modifications, or special precautions. Healthcare professionals should consider the lack of data when prescribing this medication to pregnant patients. Given the absence of established risk categories or known fetal impacts, the potential benefits and risks should be carefully weighed in the context of individual patient circumstances. Women of childbearing potential should be counseled accordingly.

Lactation

Lactating mothers are advised to consult a doctor prior to using this product. Currently, there is no specific information available regarding the potential for excretion of hydrocortisone cream in breast milk or any associated risks to breastfed infants.

Renal Impairment

Patients with renal impairment have not been specifically addressed in the drug insert regarding dosage adjustments, special monitoring, or safety considerations. Therefore, healthcare professionals should exercise caution when prescribing this medication to individuals with reduced kidney function, as the absence of detailed guidance necessitates careful clinical judgment. Regular monitoring of renal function may be prudent in these patients to ensure safety and efficacy.

Hepatic Impairment

Patients with hepatic impairment have not been specifically studied in relation to this drug. Consequently, there are no dosage adjustments, special monitoring requirements, or precautions outlined for individuals with compromised liver function. It is recommended that healthcare providers exercise caution when prescribing this medication to patients with hepatic impairment, given the lack of data on its safety and efficacy in this population. Regular monitoring of liver function may be prudent in these cases, although specific parameters are not defined in the prescribing information.

Overdosage

In the event of an overdosage, immediate medical intervention is crucial. If the substance is ingested, it is imperative to seek medical assistance or contact a Poison Control Center without delay.

Healthcare professionals should be aware that prompt action can significantly influence the outcome of an overdosage situation. Symptoms of overdosage may vary depending on the specific substance involved; therefore, a thorough assessment and monitoring of the patient are essential.

Management procedures may include supportive care and symptomatic treatment, tailored to the individual patient's needs. Continuous evaluation and appropriate interventions should be implemented based on the clinical presentation and severity of symptoms.

Nonclinical Toxicology

No teratogenic or non-teratogenic effects have been reported in the available nonclinical studies. Additionally, there is no information regarding animal pharmacology and toxicology. The absence of data in these areas limits the understanding of the compound's potential effects in nonclinical settings.

Postmarketing Experience

Serious adverse reactions to this product may be reported voluntarily by healthcare professionals and consumers. Reports can be submitted to the designated contact number, 800-634-7680.

Patient Counseling

Healthcare providers should advise patients to keep this product out of reach of children. In the event of accidental ingestion, patients should seek medical assistance or contact a Poison Control Center immediately.

Patients should be informed that this product is not intended for the treatment of diaper rash and that they should consult a doctor for appropriate alternatives.

It is important for patients to stop using the product and consult a doctor if their condition worsens, if symptoms persist for more than 7 days, or if symptoms resolve and then recur within a few days.

While using this product, patients should be cautioned to avoid contact with the eyes. Additionally, they should not initiate the use of any other hydrocortisone product without first consulting a healthcare professional.

Storage and Handling

The product is supplied in tamper-evident packaging. It is essential to avoid using any packets that are opened or torn.

For optimal storage conditions, the product should be kept at room temperature and must not be frozen.

Additional Clinical Information

The product is administered topically, with a recommended application frequency of 3 to 4 times daily for adults and children aged 2 years and older. For children under 2 years of age, consultation with a doctor is advised before use.

Clinicians should counsel patients to keep the product out of reach of children and to seek medical assistance or contact a Poison Control Center immediately if ingested. Patients are also advised to avoid contact with the eyes during use and to refrain from starting any other hydrocortisone products without prior consultation with a healthcare provider. If the condition worsens, symptoms persist beyond 7 days, or if symptoms resolve and then recur within a few days, patients should discontinue use and consult a doctor. Additionally, serious adverse reactions can be reported to 800-634-7680.

Drug Information (PDF)

This file contains official product information for Hydrocortisone, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Data Generation & Sources

This page was automatically generated and is maintained by the AllDrugs AI Data-Science Team. It was built from the FDA Structured Product Label (DailyMed) for Hydrocortisone, retrieved by a validated AI data-extraction workflow.

All FDA-listed dosage forms and strengths are shown in the Packaging & NDC Codes section above. Regulatory status appears in the Summary Information panel above and was verified in the FDA National Drug Code directory and the NSDE NDC Directory daily file.

Note: an automated daemon monitors NSDE checksums; when the record for this NDC changes, the new file is pulled instantly and this page is refreshed.

No human clinician has reviewed this version.

Learn more in our Editorial Policy

Last AI update:

Primary FDA sources:

Orange Book data shown on this page are limited to Regulatory Status (Rx), Established Pharmacologic Class (EPC), and Mechanism of Action (MoA).

Regulatory data notice: Information on this page is reproduced verbatim from FDA public databases (NSDE, Orange Book, Purple Book, DailyMed SPL). NDA/ANDA drugs are FDA-approved, BLA biologics are FDA-licensed. Inclusion alone does not guarantee current market availability or imply FDA endorsement.

Medical disclaimer: This AI-generated content is provided for educational purposes only and does not constitute medical advice. Always consult a licensed healthcare professional for diagnosis or treatment decisions.