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Hydrocortisone

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Active ingredient
Hydrocortisone 10 mg/1 g
Other brand names
Drug class
Corticosteroid
Dosage form
Cream
Route
Topical
Prescription status
OTC (over the counter)
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 2013
Label revision date
September 8, 2025
Drug Information (PDF)
Prescribing information, PDF file
Active ingredient
Hydrocortisone 10 mg/1 g
Other brand names
Drug class
Corticosteroid
Dosage form
Cream
Route
Topical
Prescription status
OTC (over the counter)
CSA schedule
Not a scheduled drug
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 2013
Label revision date
September 8, 2025
Manufacturer
Unifirst First Aid Corporation
Registration number
M017
NDC root
47682-211
Drug Information (PDF)
Prescribing information, PDF file
Packaging Info (3 NDCs)
Packaging & NDC Codes (3)

If you are a healthcare professional or from the pharmaceutical industry please visit this version.

If you are a consumer or patient please visit this version.

Drug Overview

Medi-First 1% Hydrocortisone Cream is a topical medication designed to provide temporary relief from itching caused by minor skin irritations, inflammation, and rashes. You can use it for various conditions, including eczema, insect bites, and reactions to plants like poison ivy, poison oak, and poison sumac. It may also help with irritation from soaps, detergents, cosmetics, jewelry, seborrheic dermatitis, psoriasis, and scrapes.

This cream works by reducing inflammation and soothing the skin, making it easier for you to manage discomfort from these common skin issues. However, it's important to use this product as directed and consult a doctor for any other uses.

Uses

This product is designed to provide temporary relief from itching caused by various minor skin irritations, inflammation, and rashes. You can use it for conditions such as eczema, insect bites, and reactions to plants like poison ivy, poison oak, and poison sumac. It can also help soothe irritation from soaps, detergents, cosmetics, jewelry, seborrheic dermatitis, psoriasis, and scrapes.

For any other uses, it's important to consult with your doctor to ensure it's appropriate for your situation.

Dosage and Administration

If you are an adult or a child aged 2 years and older, you can apply this medication to the affected area 3 to 4 times a day. For children under 12 years old experiencing external anal itching, it's important to consult a doctor before use. If your child is under 2 years old, do not use this product without first speaking to a doctor.

For adults dealing with external anal itching, it's best to start by gently cleansing the affected area with mild soap and warm water. Make sure to rinse thoroughly and then dry the area by patting or blotting it with toilet tissue or a soft cloth before applying the medication. This preparation helps ensure the product works effectively.

What to Avoid

It's important to use this medication safely. You should not use it for treating diaper rash, and you should avoid using it alongside any other Hydrocortisone product unless you have first consulted with your doctor. Additionally, if you have vaginal discharge, please consult your doctor before using this medication. Following these guidelines will help ensure your safety and the effectiveness of your treatment.

Side Effects

You should be aware that this product is for external use only and is not intended for treating diaper rash. If you experience any vaginal discharge, it's important to consult a doctor before using it.

If your condition worsens, lasts more than 7 days, or clears and then comes back within a few days, you should stop using the product and seek medical advice. Additionally, if you notice any bleeding or if the product is swallowed, contact a doctor or a Poison Control Center immediately. Always consult a doctor before using this product with any other Hydrocortisone product.

Warnings and Precautions

This product is for external use only, so please avoid using it on areas like diaper rash or in combination with other Hydrocortisone products unless you have spoken to your doctor. If you notice any vaginal discharge, it's important to consult your doctor before using this product.

You should stop using this product and contact your doctor if your condition worsens, lasts more than 7 days, or if it clears up and then comes back within a few days. Additionally, if you experience any bleeding, seek medical advice. If the product is swallowed, get emergency medical help or contact a Poison Control Center immediately. Remember to keep this product out of reach of children.

Overdose

If you or someone else has swallowed a medication and you suspect an overdose, it’s important to act quickly. Contact a medical professional or call a Poison Control Center immediately for assistance. They can provide guidance on what to do next.

Signs of an overdose can vary, but they may include unusual symptoms that are not typical for the medication. If you notice any concerning changes in behavior or health, don’t hesitate to seek immediate medical help. Your safety is the top priority, so getting prompt assistance is crucial.

Pregnancy Use

When it comes to using this medication during pregnancy, there is currently no specific information available about its safety, recommended dosage adjustments, or any special precautions you should take. This means that if you are pregnant or planning to become pregnant, it’s important to discuss your options with your healthcare provider. They can help you weigh the potential risks and benefits based on your individual situation. Always prioritize open communication with your doctor to ensure the best care for you and your baby.

Lactation Use

When it comes to breastfeeding, it's important to be aware that there are no specific guidelines or statements regarding nursing mothers or lactation (the process of producing milk). This means that if you are breastfeeding, you may not find detailed information about how certain medications or treatments could affect you or your baby.

If you have concerns about breastfeeding while taking any medication, it's always best to consult with your healthcare provider for personalized advice and to ensure the safety of both you and your infant.

Pediatric Use

When using this medication for children aged 2 years and older, you should apply it to the affected area 3 to 4 times a day. However, if your child is under 12 years old and experiencing external anal itching, it's important to consult a doctor before use. For children under 2 years of age, you should not use this medication without first speaking to a doctor. Always prioritize your child's safety and seek professional advice when needed.

Geriatric Use

While there is no specific information available about the use of this medication in older adults, it’s important to approach any new treatment with caution. As you age, your body may process medications differently, which can affect how well they work and the potential for side effects.

If you or a loved one is considering this medication, it’s wise to discuss it with a healthcare provider. They can help determine if any special precautions or adjustments are needed based on individual health conditions and overall well-being. Always prioritize open communication with your healthcare team to ensure safe and effective treatment.

Renal Impairment

If you have kidney problems, it's important to know that the drug insert does not provide specific information about dosage adjustments, special monitoring, or safety considerations for your condition. This means that there are no tailored guidelines for how this medication may affect you if you have renal impairment (kidney issues).

Always consult your healthcare provider for personalized advice and to ensure that any medication you take is safe and appropriate for your health situation. They can help monitor your kidney function and make any necessary adjustments to your treatment plan.

Hepatic Impairment

If you have liver problems, it's important to know that the drug insert does not provide specific information about dosage adjustments, special monitoring, or precautions for your condition. This means that there are no tailored guidelines for how this medication may affect you if you have hepatic impairment (liver issues).

Before starting any new medication, including this one, you should discuss your liver health with your healthcare provider. They can help determine the best approach for your treatment and ensure your safety.

Drug Interactions

It's important to have open conversations with your healthcare provider about any medications or tests you may be taking. While there are no specific drug interactions or laboratory test interactions noted for this medication, your healthcare provider can help ensure that everything you are taking works well together and is safe for you. Always share your complete list of medications and any health conditions you have to receive the best care possible.

Storage and Handling

To ensure the best quality and safety of your product, store it at room temperature and avoid freezing. It's important to keep the product in its original packaging, as it is tamper evident. This means that if you notice any opened or torn packets, you should not use them. Always check the packaging before use to ensure it is intact. Following these guidelines will help you maintain the product's effectiveness and safety.

Additional Information

For adults and children aged 2 years and older, apply the product to the affected area 3 to 4 times daily. If you are treating a child under 12 years for external anal itching, it's best to consult a doctor first. For children under 2 years, do not use the product without consulting a doctor. Adults should cleanse the affected area with mild soap and warm water, rinsing thoroughly, or use a suitable cleansing pad before gently drying the area with toilet tissue or a soft cloth before applying the product.

FAQ

What is Medi-First 1% Hydrocortisone Cream used for?

Medi-First 1% Hydrocortisone Cream provides temporary relief of itching associated with minor skin irritations, inflammation, and rashes due to conditions like eczema, insect bites, and poison ivy.

How should I apply Medi-First 1% Hydrocortisone Cream?

For adults and children aged 2 years and older, apply the cream to the affected area 3 to 4 times daily. For children under 2 years, consult a doctor before use.

Are there any contraindications for using this cream?

Do not use Medi-First 1% Hydrocortisone Cream for diaper rash, with any other hydrocortisone product without consulting a doctor, or if you have vaginal discharge.

What should I do if my condition worsens?

Stop using the cream and consult a doctor if your condition worsens, lasts more than 7 days, or if bleeding occurs.

Is this cream safe to use during pregnancy or while nursing?

The provided information does not specify safety concerns or precautions regarding the use of this cream during pregnancy or lactation. Consult a doctor for advice.

What should I do if I accidentally swallow the cream?

If swallowed, seek medical help or contact a Poison Control Center immediately.

How should I store Medi-First 1% Hydrocortisone Cream?

Store the cream at room temperature and do not freeze. Ensure the packaging is intact before use.

Packaging Info

Below are the non-prescription pack sizes of Hydrocortisone. Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Hydrocortisone.
Details

Drug Information (PDF)

This file contains official product information for Hydrocortisone, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Description

No description information is available for the specified drug.

Uses and Indications

This drug is indicated for the temporary relief of itching associated with minor skin irritations, inflammation, and rashes due to various conditions, including but not limited to eczema, insect bites, poison ivy, poison oak, poison sumac, soaps, detergents, cosmetics, seborrheic dermatitis, psoriasis, and scrapes.

Other uses of this product should only be undertaken under the advice and supervision of a healthcare professional.

Dosage and Administration

For adults and children aged 2 years and older, the product should be applied to the affected area 3 to 4 times daily. Prior to application, adults experiencing external anal itching are advised to cleanse the affected area with mild soap and warm water, ensuring thorough rinsing. Alternatively, the area may be cleansed by patting or blotting with an appropriate cleansing pad. After cleansing, the area should be gently dried by patting or blotting with toilet tissue or a soft cloth before applying the product.

For children under 12 years of age, particularly for external anal itching, it is recommended to consult a doctor prior to use. The product is not indicated for use in children under 2 years of age; consultation with a doctor is necessary in such cases.

Contraindications

The product is contraindicated in the following situations:

The treatment of diaper rash is not recommended. Additionally, concurrent use with any other Hydrocortisone product is contraindicated unless a healthcare professional has been consulted. Use is also contraindicated in patients presenting with vaginal discharge; consultation with a healthcare provider is advised in such cases.

Warnings and Precautions

For external use only. This product is not intended for the treatment of diaper rash. It is imperative that healthcare professionals advise patients against using this product in conjunction with any other Hydrocortisone product unless a consultation with a doctor has occurred. Additionally, if a patient presents with vaginal discharge, they should be instructed to seek medical advice prior to use.

Patients should be advised to discontinue use and consult a doctor if their condition worsens, persists for more than 7 days, or if symptoms resolve only to recur within a few days. Furthermore, if the patient begins using any other Hydrocortisone product without prior consultation with a healthcare provider, they should stop use and seek medical advice. The presence of any bleeding also necessitates immediate consultation with a healthcare professional.

In cases of accidental ingestion, it is critical to seek emergency medical assistance or contact a Poison Control Center without delay.

To ensure safety, this product must be kept out of reach of children.

Side Effects

Patients using this product should be aware of several important warnings and precautions. This medication is intended for external use only and should not be used for the treatment of diaper rash. Additionally, it should not be used in conjunction with any other hydrocortisone product unless a healthcare professional has been consulted.

Patients are advised to discontinue use and seek medical advice if their condition worsens, persists for more than 7 days, or if symptoms clear and then recur within a few days. The use of any other hydrocortisone product during treatment should also prompt consultation with a healthcare provider. Furthermore, if any bleeding occurs, patients should stop use and contact a doctor immediately.

In the event of accidental ingestion, it is crucial to seek medical assistance or contact a Poison Control Center without delay.

Drug Interactions

There are currently no documented drug interactions associated with this medication. Additionally, there is no information available regarding interactions with laboratory tests. As such, no specific recommendations for dosage adjustments or monitoring are warranted at this time.

Packaging & NDC

Below are the non-prescription pack sizes of Hydrocortisone. Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Hydrocortisone.
Details

Pediatric Use

Pediatric patients aged 2 years and older may apply the medication to the affected area 3 to 4 times daily. For children under 12 years of age experiencing external anal itching, it is advised to consult a doctor prior to use. The medication is contraindicated in children under 2 years of age; consultation with a doctor is required for this age group.

Geriatric Use

Elderly patients may not have specific information regarding the use of this medication, including dosage adjustments, safety concerns, or special precautions. Therefore, healthcare providers should exercise caution when prescribing this medication to geriatric patients. It is advisable to monitor these patients closely for any potential adverse effects or changes in efficacy, given the lack of targeted data for this population.

Pregnancy

There is no specific information available regarding the use of this medication during pregnancy, including safety concerns, dosage modifications, or special precautions. Healthcare professionals should consider the lack of data when prescribing this medication to pregnant patients and weigh the potential risks and benefits. Women of childbearing potential should be counseled on the absence of established safety data and the importance of discussing any plans for pregnancy with their healthcare provider.

Lactation

There are no specific statements regarding the use of this medication in nursing mothers or its effects during lactation. Additionally, there are no known data on excretion in breast milk or effects on breastfed infants. Healthcare professionals should consider the absence of information when advising lactating mothers about the use of this medication.

Renal Impairment

Patients with renal impairment have not been specifically addressed in the drug insert text regarding dosage adjustments, special monitoring, or safety considerations. Therefore, healthcare professionals should exercise caution when prescribing this medication to individuals with reduced kidney function, as the lack of data necessitates careful clinical judgment. Regular monitoring of renal function may be advisable in these patients, although specific recommendations are not provided.

Hepatic Impairment

Patients with hepatic impairment have not been specifically studied in relation to this medication. Consequently, there are no dosage adjustments, special monitoring requirements, or precautions outlined for individuals with compromised liver function. It is recommended that healthcare providers exercise caution when prescribing this medication to patients with hepatic impairment, given the lack of data on its safety and efficacy in this population. Regular monitoring of liver function may be prudent in these cases, although specific parameters are not defined in the prescribing information.

Overdosage

In the event of an overdosage, immediate medical intervention is crucial. If the substance is ingested, it is imperative to seek medical assistance or contact a Poison Control Center without delay.

Healthcare professionals should be aware that prompt action can significantly influence the outcome of an overdosage situation. Symptoms may vary depending on the specific substance involved, and monitoring for any adverse effects is essential.

Management of overdosage should include supportive care and symptomatic treatment as necessary. Continuous assessment of the patient's condition is recommended to address any complications that may arise.

Nonclinical Toxicology

No teratogenic or non-teratogenic effects have been reported in the available nonclinical studies. Additionally, there is no information regarding animal pharmacology and toxicology. The absence of data limits the assessment of potential risks associated with the use of the compound in these contexts.

Postmarketing Experience

No postmarketing experience details are available in the provided data.

Patient Counseling

Healthcare providers should advise patients to keep this medication out of reach of children to prevent accidental ingestion. Instruct patients that if the medication is swallowed, they should seek medical help or contact a Poison Control Center immediately.

Patients should be informed that this product is not intended for the treatment of diaper rash. It is important to emphasize that they should not use this medication in conjunction with any other Hydrocortisone product unless they have consulted with a healthcare professional.

Patients should also be cautioned against using the medication if they have vaginal discharge and should seek medical advice in such cases. They should be instructed to stop using the product and consult a doctor if their condition worsens, persists for more than 7 days, or if symptoms clear and then recur within a few days.

Additionally, patients should be advised to discontinue use and contact a healthcare provider if they begin using any other Hydrocortisone product without prior consultation. They should also seek medical attention if any bleeding occurs during the use of this medication.

Storage and Handling

The product is supplied in tamper-evident packaging. It is essential to inspect the integrity of the packets before use; any opened or torn packets should not be utilized.

For optimal preservation, the product must be stored at room temperature. It is crucial to avoid freezing, as this may compromise the quality and efficacy of the product.

Additional Clinical Information

For patients aged 2 years and older, the product should be applied to the affected area 3 to 4 times daily. For children under 12 years of age experiencing external anal itching, it is advised to consult a doctor. The product is not recommended for use in children under 2 years of age without consulting a doctor. For adults dealing with external anal itching, it is recommended to cleanse the affected area with mild soap and warm water, rinsing thoroughly or patting with an appropriate cleansing pad before gently drying with toilet tissue or a soft cloth prior to application.

No additional information is available regarding laboratory tests, abuse potential, patient counseling, or postmarketing experience.

Drug Information (PDF)

This file contains official product information for Hydrocortisone, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Data Generation & Sources

This page was automatically generated and is maintained by the AllDrugs AI Data-Science Team. It was built from the FDA Structured Product Label (DailyMed) for Hydrocortisone, retrieved by a validated AI data-extraction workflow.

All FDA-listed dosage forms and strengths are shown in the Packaging & NDC Codes section above. Regulatory status appears in the Summary Information panel above and was verified in the FDA National Drug Code directory and the NSDE NDC Directory daily file.

Note: an automated daemon monitors NSDE checksums; when the record for this NDC changes, the new file is pulled instantly and this page is refreshed.

No human clinician has reviewed this version.

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Primary FDA sources:

Orange Book data shown on this page are limited to Regulatory Status (Rx), Established Pharmacologic Class (EPC), and Mechanism of Action (MoA).

Regulatory data notice: Information on this page is reproduced verbatim from FDA public databases (NSDE, Orange Book, Purple Book, DailyMed SPL). NDA/ANDA drugs are FDA-approved, BLA biologics are FDA-licensed. Inclusion alone does not guarantee current market availability or imply FDA endorsement.

Medical disclaimer: This AI-generated content is provided for educational purposes only and does not constitute medical advice. Always consult a licensed healthcare professional for diagnosis or treatment decisions.