Medications Containing Sodium Benzoate: Comprehensive Overview & Safety Insights

Most recent label update in this list Dec 6, 2025checked dailysee data sync status

Drugs that contain sodium benzoate. Here you'll find every formulation of sodium benzoate, including dose forms, key warnings, common side effects, and pregnancy/lactation guidance. Each drug has a patient overview plus an in‑depth drug insert. The list is refreshed weekly and ordered by current user interest. Always consult a healthcare professional before taking or switching medications.

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Drug safety and usage table for patients and healthcare providers. The numeric badges in each row show how many warnings, pregnancy/lactation notes, and side‑effects are listed inside the expandable details panel.
		Warnings	Pregnancy lactation	Side effects	Trend
Sodium Phenylacetate and Sodium Benzoate Rx injection, solution, concentrateinjection	Popularity – score 100 out of 100 (most-viewed drug)	10 warnings	9 pregnancy and lactation warnings	14 side effects	Trend: was flat over 11 months; peak from Sep to Nov; low in Jan.
11 brands · First marketed 2005 · Label last revised December 6, 2025View full label-group details → Warnings Your plasma potassium levels should be carefully monitored, and appropriate treatment should be given when necessary. Please use caution if Sodium Phenylacetate and Sodium Benzoate Injection is administered to you, especially if you have congestive heart failure, severe renal insufficiency, or conditions that involve sodium retention with edema. The infusion site must be closely monitored for possible tissue infiltration during drug administration. You should be monitored for symptoms of acute neurotoxicity. Your plasma ammonia levels should be monitored during treatment. Prolonged exposure to elevated plasma ammonia levels can quickly lead to injury to your brain or even death. If Sodium Phenylacetate and Sodium Benzoate Injection extravasates into the perivenous tissues during a high flow bolus infusion, it may cause skin necrosis, particularly in infants. Repeat loading doses should not be given due to the prolonged plasma levels achieved by phenylacetate. Sodium Phenylacetate and Sodium Benzoate Injection may cause side effects typically associated with salicylate overdose, such as hyperventilation and metabolic acidosis. Your healthcare provider should monitor your blood chemistry profiles and perform frequent blood pH and pCO2 measurements. Pregnancy & Lactation Currently, there is no information available about the presence of sodium phenylacetate and sodium benzoate in human or animal milk, their effects on breastfed infants, or their impact on milk production. You should exercise caution when sodium phenylacetate and sodium benzoate injection is given to a nursing woman. It's important to weigh the developmental and health benefits of breastfeeding against your clinical need for sodium phenylacetate and sodium benzoate injection, as well as any potential adverse effects on your breastfed infant. Sodium phenylacetate and sodium benzoate injection should only be administered to you during pregnancy if it is clearly necessary. The available data on the combined use of sodium phenylacetate and sodium benzoate in pregnant women is not sufficient to determine any drug-associated risks of major birth defects, miscarriage, or adverse maternal or fetal outcomes. Animal reproduction studies have not been performed with sodium phenylacetate and sodium benzoate injection. The estimated background risk of major birth defects and miscarriage for your population is currently unknown. Every pregnancy carries a background risk of birth defects, loss, or other adverse outcomes. In the general U.S. population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is between 2 to 4% and 15 to 20%, respectively. Side Effects You may experience vomiting. There have been reports of hyperglycemia. Hypokalemia can occur. Convulsions may happen. Mental impairment has been noted. Your healthcare provider may observe decreased potassium levels. Skin necrosis due to the extravasation of Sodium Phenylacetate and Sodium Benzoate Injection can occur. Neurotoxicity related to phenylacetate has been reported in cancer patients. You may experience symptoms of acute neurotoxicity. Hyperventilation can happen. Metabolic acidosis may occur. Injury to the brain or death due to prolonged exposure to elevated plasma ammonia levels has been reported. Conditions associated with fluid overload may occur. Extravasation of sodium phenylacetate and sodium benzoate injection into the perivenous tissues during high flow bolus infusion may lead to skin necrosis. Warnings Plasma potassium levels should be carefully monitored and appropriate treatment given when necessary. Caution should be used if Sodium Phenylacetate and Sodium Benzoate Injection is administered to patients with congestive heart failure, severe renal insufficiency, or with conditions in which there is sodium retention with edema. The infusion site must be monitored closely for possible tissue infiltration during drug administration. Monitor patients for symptoms of acute neurotoxicity. Monitor plasma ammonia levels during treatment. Prolonged exposure to elevated plasma ammonia levels can rapidly result in injury to the brain or death. Extravasation of Sodium Phenylacetate and Sodium Benzoate Injection into the perivenous tissues during high flow bolus infusion may lead to skin necrosis, especially in infants. Repeat loading doses should not be administered due to prolonged plasma levels achieved by phenylacetate. Sodium Phenylacetate and Sodium Benzoate Injection may cause side effects typically associated with salicylate overdose, such as hyperventilation and metabolic acidosis. Monitor patient blood chemistry profiles and perform frequent blood pH and pCO2 measurements. Pregnancy & Lactation There are no data on the presence of sodium phenylacetate and sodium benzoate in either human or animal milk, the effects on the breastfed infant, or the effects on milk production. Caution should be exercised when sodium phenylacetate and sodium benzoate injection is administered to a nursing woman. The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for sodium phenylacetate and sodium benzoate injection and any potential adverse effects on the breastfed infant. Sodium phenylacetate and sodium benzoate injection should be given to a pregnant woman only if clearly needed. Available data on the combination use of sodium phenylacetate and sodium benzoate in pregnant women are insufficient to identify a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes. Animal reproduction studies have not been conducted with sodium phenylacetate and sodium benzoate injection. The estimated background risk of major birth defects and miscarriage for the indicated population is unknown. All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2 to 4% and 15 to 20%, respectively. Side Effects Vomiting may occur. Hyperglycemia has been reported. Hypokalemia can occur. Convulsions may happen. Mental impairment has been noted. Decreased potassium levels may be observed. Skin necrosis due to extravasation of Sodium Phenylacetate and Sodium Benzoate Injection can occur. Neurotoxicity related to phenylacetate has been reported in cancer patients. Acute neurotoxicity symptoms may occur. Hyperventilation can happen. Metabolic acidosis may occur. Injury to the brain or death due to prolonged exposure to elevated plasma ammonia levels has been reported. Conditions associated with fluid overload may occur. Extravasation of sodium phenylacetate and sodium benzoate injection into the perivenous tissues during high flow bolus infusion may lead to skin necrosis.
Beta Vulgaris, Boldo, Chelidonium Majus, Petroselinum Sativum, Taraxacum Officinale, Arsenicum Album, Bisphenol a, Coba… HOM liquid	Popularity – score 20 out of 100	4 warnings	1 pregnancy and lactation warnings	0 side effects	Trend: was flat over 11 months.
2 brands · First marketed 2019 · Label last revised May 13, 2022View full label-group details → Warnings Please keep this out of reach of children. If you suspect an overdose, seek medical help or contact a Poison Control Center immediately. If you are pregnant or breastfeeding, please consult a healthcare professional before use. Do not use this product if the seal is broken or missing. Pregnancy & Lactation If you are pregnant or breastfeeding, please consult a healthcare professional before using this product. Side Effects No side effects reported. Warnings Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. If pregnant or breastfeeding, ask a health professional before use. Do not use if seal is broken or missing. Pregnancy & Lactation If pregnant or breast-feeding, ask a health professional before use. Side Effects No side effects reported.
Boldo, Carduus Marianus, Chelidonium Majus, Petroselinum Sativum, Taraxacum Officinale, Arsenicum Album, Bisphenol a, C… HOM liquid	Popularity – score 20 out of 100	4 warnings	1 pregnancy and lactation warnings	0 side effects	Trend: was flat over 11 months.
2 brands · First marketed 2022 · Label last revised May 23, 2025View full label-group details → Warnings If you are pregnant or breastfeeding, please consult a healthcare professional before use. Please keep this out of reach of children. If you suspect an overdose, contact your physician or the Poison Control Center immediately. Do not use if the seal is broken or missing. Pregnancy & Lactation If you are pregnant or breastfeeding, please consult a healthcare professional before using this product. Side Effects No side effects reported. Warnings If pregnant or breastfeeding, ask a health professional before use. Keep out of reach of children. In case of overdose, contact a physician or Poison Control Center right away. Do not use if seal is broken or missing. Pregnancy & Lactation If pregnant or breast-feeding, ask a health professional before use. Side Effects No side effects reported.

Data Generation & Sources

This page was automatically generated and is maintained by the AllDrugs AI Data-Science Team. It was built from the FDA Structured Product Label (DailyMed) for products containing Sodium Benzoate (UNII: OJ245FE5EU), retrieved February 17, 2026 by a validated AI data-extraction workflow. Complete dosage-form information for each product is available on its individual label page. Regulatory status, pharmacologic class (EPC), and mechanism of action (MoA) were cross-checked against the FDA Orange Book. No human clinician has reviewed this version.

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Last AI update: February 17, 2026

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Regulatory data notice: Information on this page is reproduced verbatim from FDA public databases (NSDE, Orange Book, Purple Book, DailyMed SPL). NDA/ANDA drugs are FDA-approved, BLA biologics are FDA-licensed. Inclusion alone does not guarantee current market availability or imply FDA endorsement.

Medical disclaimer: This AI-generated content is provided for educational purposes only and does not constitute medical advice. Always consult a licensed healthcare professional for diagnosis or treatment decisions.