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Low Dose Aspiriun

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Active ingredient
Aspirin 81 mg
Other brand names
Drug classes
Nonsteroidal Anti-inflammatory Drug, Platelet Aggregation Inhibitor
Dosage form
Tablet, Chewable
Route
Oral
Prescription status
OTC (over the counter)
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 2025
Label revision date
November 20, 2025
Drug Information (PDF)
Prescribing information, PDF file
Active ingredient
Aspirin 81 mg
Other brand names
Drug classes
Nonsteroidal Anti-inflammatory Drug, Platelet Aggregation Inhibitor
Dosage form
Tablet, Chewable
Route
Oral
Prescription status
OTC (over the counter)
CSA schedule
Not a scheduled drug
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 2025
Label revision date
November 20, 2025
Manufacturer
AMERIFOODS TRADING COMPANY
Registration number
M013
NDC root
61504-105
Drug Information (PDF)
Prescribing information, PDF file
Packaging Info
Packaging & NDC Codes

If you are a healthcare professional or from the pharmaceutical industry please visit this version.

If you are a consumer or patient please visit this version.

Drug Overview

FIRST STREET® is a chewable medication that contains low-dose aspirin (81 mg), which is a type of nonsteroidal anti-inflammatory drug (NSAID). It is designed to provide temporary relief from minor aches and pains. The tablets come in a pleasant orange flavor and are available in a convenient pack of 108 tablets.

In addition to pain relief, this product may be part of an aspirin regimen, which some people use for heart health. However, it's important to consult with your doctor or healthcare provider before using it for this purpose or to discuss any other potential uses.

Uses

You can use this product for the temporary relief of minor aches and pains, such as headaches, muscle strains, or joint discomfort. If you're unsure about whether this product is right for you or if you have other specific needs, it's a good idea to ask your doctor for more information on additional uses.

Dosage and Administration

When taking this medication, it's important to drink a full glass of water with each dose to help with absorption. For adults and children aged 12 years and older, you should take 4 to 8 tablets every 4 hours. However, make sure not to exceed 48 tablets in a 24-hour period unless your doctor has instructed you otherwise.

If you have a child under 12 years old, it's essential to consult a doctor before giving them this medication to ensure it's safe and appropriate for their age. Always follow your healthcare provider's guidance for the best results.

What to Avoid

You should avoid using this medication if you have ever had an allergic reaction to any other pain reliever or fever reducer. Additionally, if you have recently undergone a tonsillectomy or oral surgery, do not use this medication for at least 7 days unless your doctor specifically instructs you to do so. It's important to follow these guidelines to ensure your safety and well-being.

Side Effects

Using this product may lead to some serious side effects. If you are a child or teenager recovering from chickenpox or flu-like symptoms, you should avoid it, as it could trigger Reye’s syndrome, a rare but serious condition. Be aware that aspirin can cause severe allergic reactions, which may include hives, facial swelling, asthma (wheezing), or even shock.

Additionally, this product contains a nonsteroidal anti-inflammatory drug (NSAID), which can increase the risk of severe stomach bleeding, especially if you are over 60, have a history of stomach ulcers, or are taking certain medications like blood thinners or other NSAIDs. If you experience symptoms such as feeling faint, vomiting blood, or having bloody or black stools, seek medical attention immediately. Always consult your doctor if you have a history of stomach problems, high blood pressure, or other health issues before using this product.

Warnings and Precautions

You should be aware of some important warnings and precautions when using this product. If you are a child or teenager recovering from chickenpox or flu-like symptoms, do not use this product, as it may lead to a serious condition called Reye’s syndrome. Additionally, be cautious of severe allergic reactions, which can include hives, facial swelling, asthma (wheezing), or shock. This product contains a nonsteroidal anti-inflammatory drug (NSAID), which can cause severe stomach bleeding, especially if you are over 60, have a history of stomach ulcers, or are taking certain medications like blood thinners or steroids.

Before using this product, consult your doctor if you have a history of stomach problems, high blood pressure, heart disease, liver cirrhosis, or kidney disease. It's also wise to check with a healthcare professional if you are taking medications for gout, diabetes, or arthritis. If you experience any signs of an allergic reaction or stomach bleeding—such as feeling faint, vomiting blood, or having bloody or black stools—stop using the product and seek medical help immediately. In case of an overdose, contact a Poison Control Center or seek medical assistance right away.

Overdose

If you suspect an overdose, it’s crucial to seek medical help immediately. You can contact a Poison Control Center at 1-800-222-1222 for guidance. Signs of an overdose can vary, but they may include unusual drowsiness, confusion, or difficulty breathing.

Always err on the side of caution—if you notice any concerning symptoms or if you’re unsure, don’t hesitate to get help right away. Your health and safety are the top priority.

Pregnancy Use

If you are pregnant or breastfeeding, it’s important to consult with a healthcare professional before using any medication. This is to ensure the safety of both you and your baby.

Particularly, you should avoid using aspirin during the last three months of your pregnancy unless your doctor specifically advises you to do so. Taking aspirin at this stage can lead to potential issues for your unborn child or complications during delivery. Always prioritize open communication with your healthcare provider regarding any medications you may consider.

Lactation Use

If you are pregnant or breastfeeding, it's important to consult with a healthcare professional before using any medication. This is particularly crucial if you are considering taking aspirin during the last three months of your pregnancy, as it can potentially lead to issues for your unborn child or complications during delivery. Always prioritize your health and the health of your baby by seeking guidance from your doctor.

Pediatric Use

If your child is recovering from chicken pox or has flu-like symptoms, it's important to avoid using this product, as it can increase the risk of a serious condition called Reye's syndrome (a rare but serious illness that can affect the brain and liver). If you notice any changes in your child's behavior along with nausea and vomiting, consult a doctor immediately, as these may be early signs of Reye's syndrome.

For dosing, adults and children aged 12 and older can take 4 to 8 tablets every 4 hours, but they should not exceed 48 tablets in a 24-hour period unless directed by a doctor. If your child is under 12 years old, please consult a doctor before giving them this medication.

Geriatric Use

As you age, certain health risks can increase, particularly when it comes to medications. If you are 60 years or older, be aware that the risk of severe stomach bleeding is higher. It’s important to talk to your doctor before using any medication if you have a history of stomach issues, high blood pressure, heart disease, liver cirrhosis (a liver condition), or kidney disease. Your doctor can help determine the safest options for you, ensuring that your health is prioritized.

Renal Impairment

If you have kidney problems, it's important to consult your doctor before using this medication. This is especially crucial if you also have high blood pressure, heart disease, or liver cirrhosis, as these conditions can affect how your body processes the medication. Your healthcare provider can help determine if this treatment is safe for you and whether any adjustments are needed based on your kidney function. Always prioritize open communication with your doctor regarding your health conditions.

Hepatic Impairment

If you have liver problems, such as liver cirrhosis (a severe scarring of the liver), it’s important to consult your doctor before using this medication. Your healthcare provider can help determine if it’s safe for you and may need to adjust your dosage or monitor your condition closely.

Always inform your doctor about any other health issues you may have, including high blood pressure or heart disease, as these can also affect your treatment plan. Taking these precautions can help ensure your safety and the effectiveness of your medication.

Drug Interactions

It's important to have open conversations with your healthcare provider about any medications or tests you may be taking. While there are no specific drug interactions or laboratory test interactions noted for this medication, your healthcare provider can help ensure that everything you are taking works well together and is safe for you. Always share your complete list of medications and any health conditions you have to receive the best care possible.

Storage and Handling

To ensure the best performance of your product, store it in a dry place at a temperature between 20°-25°C (68°-77°F). This helps maintain its effectiveness and safety. It's also important to keep the original carton, as it contains essential information and warnings that you may need to refer to later.

When handling the product, always do so with care to avoid any damage. Following these storage and handling guidelines will help you use the product safely and effectively.

Additional Information

You should take this medication orally. Before using it for your heart, it's important to talk to your doctor or another healthcare provider to ensure it's appropriate for you. They can provide guidance tailored to your specific health needs.

FAQ

What is FIRST STREET®?

FIRST STREET® is a low dose aspirin (81 mg) chewable pain reliever with an orange flavor, available in a pack of 108 tablets.

What is FIRST STREET® used for?

It is used for the temporary relief of minor aches and pains or as recommended by your doctor.

What should I do before using FIRST STREET®?

Talk to your doctor or healthcare provider before using this product, especially if you have heart conditions or other health issues.

What are the dosing instructions for adults?

Adults and children 12 years and over should take 4 to 8 tablets every 4 hours, not exceeding 48 tablets in 24 hours unless directed by a doctor.

Are there any contraindications for using FIRST STREET®?

Do not use if you have had an allergic reaction to any pain reliever/fever reducer or for at least 7 days after tonsillectomy or oral surgery unless directed by a doctor.

What are the warnings associated with FIRST STREET®?

Warnings include the risk of Reye's syndrome in children recovering from chicken pox or flu-like symptoms, severe allergic reactions, and the potential for stomach bleeding.

What should I do if I experience signs of stomach bleeding?

Stop use and seek medical help if you feel faint, vomit blood, have bloody or black stools, or have stomach pain that does not improve.

Can I use FIRST STREET® if I am pregnant or breastfeeding?

Consult a health professional before use, especially during the last 3 months of pregnancy, as it may cause complications.

How should I store FIRST STREET®?

Store between 20°-25°C (68°-77°F) in a dry place and retain the carton for complete product information and warnings.

Packaging Info

Below are the non-prescription pack sizes of Low Dose Aspiriun (aspirin). Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Low Dose Aspiriun.
Details

Drug Information (PDF)

This file contains official product information for Low Dose Aspiriun, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Description

No description information is available for the drug.

Uses and Indications

This drug is indicated for the temporary relief of minor aches and pains, or as recommended by a healthcare professional. Healthcare providers may consider additional uses for this product based on individual patient needs.

There are no teratogenic or nonteratogenic effects associated with this drug.

Dosage and Administration

Patients are advised to take a full glass of water with each dose to ensure proper administration and absorption of the medication.

For adults and children aged 12 years and older, the recommended dosage is 4 to 8 tablets every 4 hours. The total daily dosage should not exceed 48 tablets within a 24-hour period unless otherwise directed by a healthcare professional.

For children under 12 years of age, it is essential to consult a doctor before administering this medication to determine the appropriate dosage and ensure safety.

Contraindications

Use is contraindicated in patients with a history of allergic reactions to any other pain reliever or fever reducer. Additionally, the product should not be used for at least 7 days following a tonsillectomy or oral surgery, unless specifically directed by a healthcare professional.

Warnings and Precautions

Children and teenagers who have or are recovering from chickenpox or flu-like symptoms should not use this product. If any changes in behavior accompanied by nausea and vomiting occur while using this product, it is imperative to consult a physician, as these symptoms may indicate the onset of Reye’s syndrome, a rare but serious condition.

Aspirin, a component of this product, has the potential to cause severe allergic reactions. Symptoms may include hives, facial swelling, asthma (wheezing), and shock. Additionally, this product contains a nonsteroidal anti-inflammatory drug (NSAID), which may lead to severe stomach bleeding. The risk of such adverse effects is heightened in individuals who meet any of the following criteria:

  • Are aged 60 years or older

  • Have a history of stomach ulcers or bleeding problems

  • Are concurrently taking blood-thinning (anticoagulant) or steroid medications

  • Are using other medications that contain prescription or nonprescription NSAIDs (such as aspirin, ibuprofen, or naproxen)

  • Consume three or more alcoholic beverages daily while using this product

  • Exceed the recommended dosage or duration of use.

Healthcare professionals should advise patients to seek medical guidance prior to using this product if any of the following conditions apply:

  • A history of stomach bleeding

  • Previous stomach issues, such as heartburn

  • High blood pressure, heart disease, liver cirrhosis, or kidney disease

  • Use of diuretics

  • A diagnosis of asthma.

Furthermore, patients should consult a doctor or pharmacist before using this product if they are taking prescription medications for gout, diabetes, or arthritis.

In the event of an overdose, immediate medical assistance should be sought, or the Poison Control Center should be contacted at 1-800-222-1222.

Patients are advised to discontinue use and contact a healthcare provider if any of the following occur:

  • Signs of an allergic reaction, which require immediate medical attention

  • Symptoms indicative of stomach bleeding, such as feeling faint, vomiting blood, having bloody or black stools, or experiencing persistent stomach pain

  • Worsening pain that lasts more than 10 days

  • Fever that worsens or persists beyond three days

  • Presence of redness or swelling

  • Onset of new symptoms

  • Ringing in the ears or loss of hearing.

Side Effects

Patients using this product may experience a range of adverse reactions, some of which can be serious.

Reye's syndrome is a rare but serious illness that may occur in children and teenagers who have or are recovering from chickenpox or flu-like symptoms. It is crucial for these individuals to avoid using this product. If patients exhibit changes in behavior accompanied by nausea and vomiting while using this product, they should consult a doctor immediately, as these symptoms could indicate the onset of Reye's syndrome.

Aspirin, an active ingredient in this product, may cause severe allergic reactions in some patients. Symptoms of such reactions can include hives, facial swelling, asthma (wheezing), and shock. Patients experiencing any signs of an allergic reaction should seek medical attention promptly.

This product contains a nonsteroidal anti-inflammatory drug (NSAID), which carries a risk of severe stomach bleeding. The likelihood of this adverse reaction is increased in patients who are 60 years of age or older, have a history of stomach ulcers or bleeding problems, are taking anticoagulants or steroid medications, consume three or more alcoholic drinks daily while using this product, or exceed the recommended dosage or duration of use.

Patients should discontinue use and consult a doctor if they experience any signs of stomach bleeding, which may include feeling faint, vomiting blood, having bloody or black stools, or experiencing persistent stomach pain. Additionally, if pain worsens or lasts more than 10 days, if fever intensifies or lasts more than three days, if redness or swelling occurs, if new symptoms arise, or if there is ringing in the ears or loss of hearing, medical advice should be sought.

Before using this product, patients should consult a doctor if they have a history of stomach problems, such as heartburn, or if they have high blood pressure, heart disease, liver cirrhosis, or kidney disease. It is also advisable to seek medical guidance if they are taking diuretics or have asthma.

Furthermore, patients should ask a doctor or pharmacist before use if they are currently taking prescription medications for gout, diabetes, or arthritis, as these may interact with the product.

Drug Interactions

There are currently no documented drug interactions associated with this medication. Additionally, there are no known interactions with laboratory tests. As such, no specific recommendations for dosage adjustments or monitoring are warranted at this time.

Packaging & NDC

Below are the non-prescription pack sizes of Low Dose Aspiriun (aspirin). Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Low Dose Aspiriun.
Details

Pediatric Use

Pediatric patients, particularly children and teenagers, should not use this product if they have or are recovering from chicken pox or flu-like symptoms due to the risk of Reye's syndrome. Healthcare professionals are advised to consult a doctor if any changes in behavior accompanied by nausea and vomiting occur, as these may be early signs of Reye’s syndrome.

For dosing, adults and children aged 12 years and older may take 4 to 8 tablets every 4 hours, with a maximum of 48 tablets in 24 hours unless otherwise directed by a physician. For children under 12 years, it is essential to consult a doctor before use to ensure safety and appropriate dosing.

Geriatric Use

Elderly patients, particularly those aged 60 and older, may have an increased risk of severe stomach bleeding. It is essential for healthcare providers to assess this risk when prescribing treatment to geriatric patients.

Before initiating therapy, healthcare providers should inquire about the patient's medical history, especially regarding any previous stomach issues, high blood pressure, heart disease, liver cirrhosis, or kidney disease. If any of these conditions are present, a thorough evaluation and consultation with a physician are recommended prior to use.

Close monitoring of elderly patients is advised to ensure safety and to mitigate potential adverse effects associated with treatment. Adjustments to dosage may be necessary based on individual patient assessments and clinical findings.

Pregnancy

Pregnant patients and those who are breastfeeding should consult a healthcare professional prior to use. The use of aspirin during the last trimester of pregnancy is particularly cautioned against, as it may lead to adverse effects on the unborn child or complications during delivery. Therefore, it is essential that pregnant patients only use aspirin in this period if explicitly directed by a physician.

Lactation

Lactating mothers are advised to consult a health professional prior to using this medication. It is particularly important to avoid the use of aspirin during the last three months of pregnancy unless explicitly directed by a physician, as it may pose risks to the unborn child or lead to complications during delivery. There is no specific data available regarding the excretion of this medication in breast milk or its effects on breastfed infants. Therefore, caution is recommended when considering its use in lactating individuals.

Renal Impairment

Patients with renal impairment should consult a healthcare professional prior to use, particularly if they have conditions such as high blood pressure, heart disease, liver cirrhosis, or kidney disease. It is essential to assess renal function and consider potential dosing adjustments or monitoring requirements based on the severity of renal impairment.

Hepatic Impairment

Patients with hepatic impairment should consult a healthcare professional prior to use, particularly if they have conditions such as liver cirrhosis. It is essential for these patients to receive appropriate evaluation and monitoring of their liver function to ensure safe use of the medication. Adjustments to dosage or specific monitoring parameters may be necessary based on the severity of hepatic impairment. Therefore, healthcare providers should assess the individual patient's liver function and overall health status before initiating treatment.

Overdosage

In the event of an overdose, it is imperative to seek immediate medical assistance or contact a Poison Control Center without delay. The national Poison Control Center can be reached at 1-800-222-1222.

Healthcare professionals should be aware that timely intervention is crucial in managing overdose situations. Symptoms of overdose may vary depending on the substance involved, and it is essential to monitor the patient closely for any signs of adverse reactions.

Management of an overdose typically involves supportive care and symptomatic treatment. Healthcare providers should ensure that the patient is stabilized and may need to implement specific protocols based on the substance taken. Continuous assessment and monitoring of vital signs are recommended to guide further treatment decisions.

In summary, prompt action and appropriate medical intervention are vital in the management of overdose cases to mitigate potential complications and ensure patient safety.

Nonclinical Toxicology

It is especially important not to use aspirin during the last three months of pregnancy unless specifically directed by a healthcare professional, as it may lead to complications for the unborn child or during delivery. No specific non-teratogenic effects have been identified in the available data. Additionally, there are no details regarding nonclinical toxicology or animal pharmacology and toxicology provided in the current information.

Postmarketing Experience

No postmarketing experience details are provided in the insert.

Patient Counseling

Healthcare providers should advise patients to keep this medication out of reach of children to prevent accidental ingestion. In the event of an overdose, patients should be instructed to seek medical help immediately or contact a Poison Control Center at 1-800-222-1222.

Patients should be cautioned against using this medication if they have a history of allergic reactions to any other pain reliever or fever reducer. It is important to inform patients that they should not use this medication for at least 7 days following a tonsillectomy or oral surgery unless specifically directed by a healthcare professional.

Patients must be informed to stop using the medication and consult a doctor if they experience any signs of an allergic reaction or if they notice symptoms indicative of stomach bleeding, such as feeling faint, vomiting blood, having bloody or black stools, or experiencing persistent stomach pain. Additionally, they should be advised to seek medical attention if their pain worsens or lasts longer than 10 days, if their fever worsens or persists beyond 3 days, or if they observe any redness or swelling. New symptoms, ringing in the ears, or loss of hearing should also prompt a consultation with a healthcare provider, as these may indicate a serious condition.

Patients should be encouraged to consult a doctor before using this medication if they have a history of stomach problems, such as heartburn, or if the stomach bleeding warning applies to them. It is also essential to discuss any existing conditions such as high blood pressure, heart disease, liver cirrhosis, or kidney disease, as well as the use of diuretics, asthma medications, or prescription drugs for gout, diabetes, or arthritis, as these may influence the safety and efficacy of the medication.

Storage and Handling

The product is supplied in a carton that contains essential information and warnings. It should be stored in a dry place at a temperature range of 20°-25°C (68°-77°F) to ensure optimal stability and efficacy. It is recommended to retain the carton for reference to complete product information.

Additional Clinical Information

The product is administered orally. Clinicians should advise patients to consult with their doctor or healthcare provider prior to using this product, particularly in relation to heart health. No further information is available regarding laboratory tests, abuse potential, or postmarketing experiences.

Drug Information (PDF)

This file contains official product information for Low Dose Aspiriun, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Data Generation & Sources

This page was automatically generated and is maintained by the AllDrugs AI Data-Science Team. It was built from the FDA Structured Product Label (DailyMed) for Low Dose Aspiriun, retrieved by a validated AI data-extraction workflow.

All FDA-listed dosage forms and strengths are shown in the Packaging & NDC Codes section above. Regulatory status appears in the Summary Information panel above and was verified in the FDA National Drug Code directory and the NSDE NDC Directory daily file.

Note: an automated daemon monitors NSDE checksums; when the record for this NDC changes, the new file is pulled instantly and this page is refreshed.

No human clinician has reviewed this version.

Learn more in our Editorial Policy

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Primary FDA sources:

Orange Book data shown on this page are limited to Regulatory Status (Rx), Established Pharmacologic Class (EPC), and Mechanism of Action (MoA).

Regulatory data notice: Information on this page is reproduced verbatim from FDA public databases (NSDE, Orange Book, Purple Book, DailyMed SPL). NDA/ANDA drugs are FDA-approved, BLA biologics are FDA-licensed. Inclusion alone does not guarantee current market availability or imply FDA endorsement.

Medical disclaimer: This AI-generated content is provided for educational purposes only and does not constitute medical advice. Always consult a licensed healthcare professional for diagnosis or treatment decisions.