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Cramergesic

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Active ingredients
  • Menthol 19 mg/1 g
  • Methyl Salicylate 137 mg/1 g
Other brand names
Dosage form
Ointment
Route
Topical
Prescription status
OTC (over the counter)
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 2022
Label revision date
October 13, 2025
Drug Information (PDF)
Prescribing information, PDF file
Active ingredients
  • Menthol 19 mg/1 g
  • Methyl Salicylate 137 mg/1 g
Other brand names
Dosage form
Ointment
Route
Topical
Prescription status
OTC (over the counter)
CSA schedule
Not a scheduled drug
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 2022
Label revision date
October 13, 2025
Manufacturer
The Hygenic Company, LLC
Registration number
M017
NDC root
82345-854
Drug Information (PDF)
Prescribing information, PDF file
Packaging Info
Packaging & NDC Codes

If you are a healthcare professional or from the pharmaceutical industry please visit this version.

If you are a consumer or patient please visit this version.

Drug Overview

Cramergesic is a medication designed to provide temporary relief from minor aches and pains in muscles and joints. It is commonly used for conditions such as strains, sprains, bruises, simple backache, and arthritis. When combined with stretching and calisthenics, Cramergesic can help enhance your warm-up process, particularly in cool, damp weather, making it a supportive option for managing discomfort during physical activity.

Uses

If you're dealing with minor aches and pains in your muscles and joints, such as those from strains, sprains, bruises, simple backaches, or arthritis, Cramergesic can provide temporary relief. It's particularly effective when combined with stretching and calisthenics, helping you warm up, especially in cool, damp weather. Just remember not to bandage too tightly while using it.

Rest assured, there are no concerns about teratogenic effects (which refer to substances that can cause birth defects) or nonteratogenic effects associated with this product.

Dosage and Administration

To use Cramergesic effectively, start by gently massaging it into the painful area of your body. If you are an adult or a child aged 6 years and older, you can apply it to the affected area up to 3 to 4 times a day. For children under 6 years old, it’s important to consult a doctor before use.

When applying Cramergesic, spread a thin layer, about 1/8 of an inch thick, over the area that hurts. Be careful not to wrap or bandage the area tightly after application, as this can cause discomfort. Following these steps will help ensure you get the most benefit from the medication.

What to Avoid

It's important to be aware of specific guidelines when using this medication. You should not administer it to children or teenagers who have chicken pox or the flu, as this could lead to serious health issues.

Currently, there are no listed contraindications, controlled substance classifications, or concerns regarding abuse, misuse, or dependence associated with this medication. Always follow these instructions to ensure safe use.

Side Effects

It's important to use this product only as directed and for external use only. If you accidentally ingest it, seek professional help or contact a Poison Control Center right away. Avoid applying it to wounds or damaged skin, and keep it away from your eyes. If your condition worsens, persists for more than 7 days, or clears up and then returns within a few days, stop using the product and consult your doctor.

Warnings and Precautions

This product is for external use only, so please do not ingest it. If you accidentally swallow it, seek professional help or contact a Poison Control Center right away. Avoid applying it to any wounds or damaged skin, and be careful to keep it away from your eyes.

If your condition worsens, if symptoms last longer than 7 days, or if they improve and then return within a few days, stop using the product and consult your doctor. It's also important to talk to your doctor before using this product on children or teenagers who have chicken pox or the flu. Always keep this and all medications out of the reach of children to prevent accidental poisoning.

Overdose

If you or someone else accidentally takes too much of a medication, it’s important to act quickly. Seek professional assistance or contact a Poison Control Center immediately to help prevent a potential overdose. Signs of an overdose can vary, but they may include unusual drowsiness, confusion, or difficulty breathing.

To protect children, always keep this and all medications out of their reach to prevent accidental poisoning. Remember, if you suspect an overdose, don’t hesitate to get help right away. Your prompt action can make a significant difference.

Pregnancy Use

When it comes to using Cramergesic (menthol, methyl salicylate ointment) during pregnancy, there is currently no specific information available about its safety, recommended dosage adjustments, or any special precautions you should take. This means that if you are pregnant or planning to become pregnant, it’s important to consult with your healthcare provider before using this product. They can help you weigh the potential risks and benefits based on your individual situation. Always prioritize your health and the health of your baby by seeking professional advice.

Lactation Use

If you are breastfeeding and considering using Cramergesic, it’s important to consult your doctor first. This is because there is a possibility that the medication could be passed into your breast milk, and the safety of Cramergesic for nursing mothers and their infants has not been fully established. Therefore, exercising caution is advised when using this product while breastfeeding. Your healthcare provider can help you weigh the benefits and risks to ensure the best outcome for you and your baby.

Pediatric Use

Before giving this medication to your child, especially if they have chicken pox or the flu, it's important to consult with a doctor. For children aged 6 years and older, you can apply the medication to the affected area up to 3 to 4 times a day. However, if your child is under 6 years old, you should also consult a doctor before use to ensure their safety. Always prioritize your child's health by seeking professional advice when it comes to medications.

Geriatric Use

When it comes to using this medication in older adults, there is no specific information available about dosage adjustments, safety concerns, or special precautions. This means that if you or a loved one is an older adult considering this medication, it’s important to consult with a healthcare provider. They can help determine the best approach based on individual health needs and any other medications being taken. Always prioritize open communication with your healthcare team to ensure safe and effective treatment.

Renal Impairment

If you have kidney problems, it's important to know that there are no specific guidelines, dosage adjustments, or monitoring requirements mentioned for your condition in the provided information. This means that the standard recommendations for medication use may apply to you without any special considerations. However, always consult your healthcare provider for personalized advice and to ensure your treatment is safe and effective based on your kidney health.

Hepatic Impairment

If you have liver problems, it's important to know that there are no specific guidelines or dosage adjustments mentioned for your condition in the available information. This means that the standard recommendations for the medication do not change based on liver impairment. However, it’s always a good idea to discuss your liver health with your healthcare provider, as they can offer personalized advice and monitor your condition effectively.

Make sure to keep your doctor informed about any liver issues you may have, as they can help ensure that your treatment is safe and appropriate for you.

Drug Interactions

It's important to have open conversations with your healthcare provider about any medications or tests you may be taking. While there are no specific drug interactions or laboratory test interactions noted for this medication, your healthcare provider can help ensure that everything you are taking works well together and is safe for you. Always share your complete list of medications and any health conditions you have to receive the best care possible.

Storage and Handling

To ensure the best performance and safety of your product, store it in a cool, dry place with the cap tightly closed. This helps protect the contents from moisture and temperature fluctuations, which can affect their effectiveness.

When handling the product, always make sure to keep the cap securely fastened when not in use to maintain its integrity. Following these simple storage and handling guidelines will help you use the product safely and effectively.

Additional Information

You should apply this medication topically to the affected area, using it no more than 3 to 4 times a day if you are an adult or a child aged 6 years and older. If the patient is under 6 years old, it's important to consult a doctor before use.

Be sure to stop using the product if you experience excessive skin irritation, and use it cautiously on sensitive skin. Store the medication in a cool, dry place with the cap tightly closed to maintain its effectiveness.

FAQ

What is Cramergesic used for?

Cramergesic is used for the temporary relief of minor aches and pains of muscles and joints associated with strains, sprains, bruises, simple backache, and arthritis.

How should I apply Cramergesic?

Gently massage Cramergesic into the painful area. For adults and children 6 years and older, apply to the affected area not more than 3-4 times daily.

Can I use Cramergesic on children?

Consult a doctor before administering Cramergesic to children under 6 years of age or to children with chicken pox or flu.

Are there any warnings for using Cramergesic?

Cramergesic is for external use only. Avoid contact with eyes, do not apply to wounds or damaged skin, and discontinue use if symptoms worsen or persist for more than 7 days.

Is Cramergesic safe to use during pregnancy?

There is no specific information regarding the safety of Cramergesic during pregnancy, so consult a doctor before use.

What should nursing mothers know about Cramergesic?

Nursing mothers should consult a doctor before using Cramergesic, as there is a potential for excretion in breast milk.

How should I store Cramergesic?

Store Cramergesic in a cool, dry place with the cap closed tightly.

What should I do in case of accidental ingestion of Cramergesic?

In case of accidental ingestion, seek professional assistance or contact a Poison Control Center immediately.

Packaging Info

Below are the non-prescription pack sizes of Cramergesic (menthol, methyl salicylate). Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Cramergesic.
Details

Drug Information (PDF)

This file contains official product information for Cramergesic, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Description

No description information is available for the specified drug.

Uses and Indications

This drug is indicated for the temporary relief of minor aches and pains of muscles and joints associated with strains, sprains, bruises, simple backache, and arthritis. It is recommended that Cramergesic be used in conjunction with stretching and calisthenics to assist in the warm-up process, particularly in cool, damp weather. It is advised not to bandage tightly when using this product.

There are no teratogenic or nonteratogenic effects associated with this drug.

Dosage and Administration

For adults and children aged 6 years and older, Cramergesic should be applied to the affected area not more than 3 to 4 times daily. A thin layer, approximately 1/8 inch, should be spread evenly over the painful area. It is important to gently massage the product into the skin to enhance absorption.

For children under 6 years of age, it is advised to consult a healthcare professional before use. When applying Cramergesic, do not bandage the area tightly to ensure proper ventilation and avoid skin irritation.

Contraindications

Administration is contraindicated in children and teenagers with chicken pox or influenza due to the potential for serious complications. No other contraindications have been identified.

Warnings and Precautions

This product is intended for external use only and should be utilized strictly as directed. In the event of accidental ingestion, it is imperative to seek professional assistance or contact a Poison Control Center immediately.

Application of this product is contraindicated on wounds or damaged skin. Care should be taken to avoid contact with the eyes, as this may lead to irritation or injury.

Healthcare professionals should advise patients to discontinue use and consult a doctor if the condition worsens, if symptoms persist for more than 7 days, or if symptoms resolve and then recur within a few days.

Prior to administration in children, including teenagers with chicken pox or flu, consultation with a healthcare provider is recommended to ensure safety and appropriateness of use.

It is essential to keep this and all medications out of the reach of children to prevent the risk of accidental poisoning.

Side Effects

Patients should be aware that the product is intended for external use only and must be used strictly as directed. In the event of accidental ingestion, it is imperative to seek professional assistance or contact a Poison Control Center immediately.

The product should not be applied to wounds or damaged skin, and contact with the eyes should be avoided. If the condition worsens, if symptoms persist for more than 7 days, or if symptoms clear up and then recur within a few days, patients are advised to discontinue use and consult a healthcare professional.

Drug Interactions

There are currently no documented drug interactions associated with this medication. Additionally, there is no information available regarding interactions with laboratory tests. As such, no specific recommendations for dosage adjustments or monitoring are warranted at this time.

Packaging & NDC

Below are the non-prescription pack sizes of Cramergesic (menthol, methyl salicylate). Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Cramergesic.
Details

Pediatric Use

Pediatric patients, including teenagers, should be advised to consult a healthcare professional before administering this medication, particularly in cases of chicken pox or flu. For those aged 6 years and older, the recommended application is to the affected area no more than 3 to 4 times daily. In children under 6 years of age, it is essential to seek medical advice prior to use.

Geriatric Use

Elderly patients may not have specific information regarding the use of this medication, including dosage adjustments, safety concerns, or special precautions. Therefore, healthcare providers should exercise caution when prescribing this medication to geriatric patients. It is advisable to monitor these patients closely for any adverse effects or changes in efficacy, given the lack of targeted data for this population.

Pregnancy

There is no specific information available regarding the use of Cramergesic (menthol, methyl salicylate ointment) during pregnancy. As such, the safety of this medication in pregnant patients has not been established, and there are no known dosage modifications or special precautions recommended for use during pregnancy. Healthcare professionals should consider the lack of data when prescribing this medication to women of childbearing potential and weigh the potential benefits against any unknown risks to fetal outcomes.

Lactation

Nursing mothers should consult a doctor before using Cramergesic. There is a potential for excretion of Cramergesic in breast milk, and the safety of this product during lactation has not been established. Caution is advised when using Cramergesic while breastfeeding.

Renal Impairment

There is no information available regarding renal impairment, dosage adjustments, special monitoring, or safety considerations for patients with reduced kidney function. Healthcare professionals should exercise caution and consider individual patient factors when treating patients with renal impairment, as specific guidelines or recommendations are not provided.

Hepatic Impairment

There is no information available regarding the use of this medication in patients with hepatic impairment. Consequently, there are no dosage adjustments, special monitoring requirements, or precautions specified for individuals with compromised liver function. Healthcare professionals should exercise caution and consider the lack of data when prescribing this medication to patients with liver problems.

Overdosage

In the event of accidental ingestion, it is imperative to seek professional assistance or contact a Poison Control Center immediately to mitigate the risk of potential overdose. Prompt action is essential to ensure the safety and well-being of the individual involved.

To prevent accidental poisoning, it is crucial to keep this medication, along with all other drugs, out of the reach of children. Proper storage and handling can significantly reduce the risk of unintentional exposure and subsequent overdose.

Nonclinical Toxicology

No teratogenic or non-teratogenic effects have been reported in the available nonclinical studies. Additionally, there is no information regarding animal pharmacology and toxicology. The absence of data limits the assessment of potential risks associated with the use of the compound in question. Further studies may be necessary to elucidate these aspects of nonclinical toxicology.

Postmarketing Experience

No postmarketing experience details are available in the insert.

Patient Counseling

Healthcare providers should advise patients to keep this medication and all other drugs out of the reach of children to prevent accidental poisoning. It is crucial to emphasize the importance of safeguarding medications, as children may inadvertently ingest them.

Additionally, healthcare providers should recommend that patients consult a doctor before administering this medication to children, including teenagers, who are experiencing chicken pox or flu. This precaution is essential to ensure the safety and appropriateness of treatment in these specific circumstances.

Storage and Handling

The product is supplied in a configuration that ensures optimal preservation of its integrity. It is essential to store the product in a cool, dry place, ensuring that the cap is closed tightly to prevent contamination and maintain efficacy. Proper storage conditions are critical for the product's stability and longevity.

Additional Clinical Information

The product is administered topically, with a recommended application frequency of 3 to 4 times daily for adults and children aged 6 years and older. For children under 6 years of age, consultation with a doctor is advised prior to use. Clinicians should counsel patients to discontinue use if excessive skin irritation occurs and to exercise caution when applying to sensitive skin. Proper storage is essential; the product should be kept in a cool, dry place with the cap tightly closed.

Drug Information (PDF)

This file contains official product information for Cramergesic, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Data Generation & Sources

This page was automatically generated and is maintained by the AllDrugs AI Data-Science Team. It was built from the FDA Structured Product Label (DailyMed) for Cramergesic, retrieved by a validated AI data-extraction workflow.

All FDA-listed dosage forms and strengths are shown in the Packaging & NDC Codes section above. Regulatory status appears in the Summary Information panel above and was verified in the FDA National Drug Code directory and the NSDE NDC Directory daily file.

Note: an automated daemon monitors NSDE checksums; when the record for this NDC changes, the new file is pulled instantly and this page is refreshed.

No human clinician has reviewed this version.

Learn more in our Editorial Policy

Last AI update:

Primary FDA sources:

Orange Book data shown on this page are limited to Regulatory Status (Rx), Established Pharmacologic Class (EPC), and Mechanism of Action (MoA).

Regulatory data notice: Information on this page is reproduced verbatim from FDA public databases (NSDE, Orange Book, Purple Book, DailyMed SPL). NDA/ANDA drugs are FDA-approved, BLA biologics are FDA-licensed. Inclusion alone does not guarantee current market availability or imply FDA endorsement.

Medical disclaimer: This AI-generated content is provided for educational purposes only and does not constitute medical advice. Always consult a licensed healthcare professional for diagnosis or treatment decisions.