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Dendracin Neurodendraxcin

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Active ingredients
  • Capsaicin 0.015 g/60 mL
  • Menthol 6 g/60 mL
  • Methyl Salicylate 18 g/60 mL
Other brand names
Dosage form
Lotion
Route
Topical
Prescription status
OTC (over the counter)
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 2011
Label revision date
November 10, 2025
Drug Information (PDF)
Prescribing information, PDF file
Active ingredients
  • Capsaicin 0.015 g/60 mL
  • Menthol 6 g/60 mL
  • Methyl Salicylate 18 g/60 mL
Other brand names
Dosage form
Lotion
Route
Topical
Prescription status
OTC (over the counter)
CSA schedule
Not a scheduled drug
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 2011
Label revision date
November 10, 2025
Manufacturer
Physicians Science & Nature Inc.
Registration number
M017
NDC root
27495-014
Drug Information (PDF)
Prescribing information, PDF file
Packaging Info (2 NDCs)
Packaging & NDC Codes (2)

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Drug Overview

DENDRACIN is a topical pain relief lotion designed to provide temporary relief from mild pain associated with muscular strain, arthritis, and simple back pain. It features a deep penetrating action and is dermatologically tested to ensure it is hypoallergenic, making it suitable for various skin types.

This product is available in two sizes: 60 ml (2 fl oz) and 120 ml (4 fl oz). While DENDRACIN can help alleviate discomfort, it is important to note that it does not cure any underlying diseases.

Uses

If you're experiencing mild pain from conditions like muscular strain, arthritis, or simple back pain, this medication can provide temporary relief. It's important to note that while it can help ease your discomfort, it does not cure any underlying diseases.

You can use this medication to manage your pain effectively, allowing you to carry on with your daily activities more comfortably. Always remember to consult with a healthcare professional if you have any questions or concerns about your pain management.

Dosage and Administration

When using this medication, it's important to follow the directions provided. Start by shaking the container well before each use. Before you apply it for the first time, take a moment to rub a small amount on your skin to check for any sensitivity or allergic reactions. If you don’t experience any adverse effects, you can gently rub the medication over the areas that are painful.

Make sure to let the area dry completely before coming into contact with your clothes or bedding, as this can help prevent any staining. After applying the medication, wash your hands thoroughly to avoid spreading it to other areas. Remember, you should not use this medication more than four times a day, and it’s not recommended if you are pregnant or nursing. If the medication accidentally gets into your eyes, rinse them with cold water immediately and contact a doctor for further advice.

What to Avoid

You should avoid using this product if you have cuts or infected skin, as it may worsen the condition. It is also not safe for children under 12 years old. Be cautious about using large amounts, particularly on raw or blistered skin, as this can lead to further irritation. Additionally, do not use this product if you are allergic to any of its ingredients, including PABA, aspirin products, or sulfa. Always prioritize your safety and consult a healthcare professional if you have any concerns.

Side Effects

You should be aware that this product is for external use only and should not come into contact with your eyes, mouth, mucous membranes, or genitals. It's important to avoid tightly bandaging the treated area, using it with a heating pad, or combining it with other topical pain products. Additionally, be cautious as it may stain furniture, clothing, or bedding.

If you experience severe, undiagnosed pain, or if your pain worsens or lasts more than seven days, you should stop using the product and consult a physician. You should also seek medical advice if you notice any itching or rash after use, or if your pain improves and then comes back a few days later.

Warnings and Precautions

This product is for external use only, so please avoid applying it to your eyes, mouth, mucous membranes, or genitals. Be careful not to let treated skin come into contact with infants or pets, and do not tightly bandage the area or use it with a heating pad or other topical pain products. Additionally, it may stain furniture, clothing, or bedding, so take precautions to protect these items.

You should not use this product on cuts or infected skin, on children under 12 years old, or in large amounts, especially on raw or blistered skin. If you are allergic to any ingredients, including PABA, aspirin products, or sulfa, please avoid using it. If you experience severe pain that is not diagnosed, if your pain worsens or lasts more than 7 days, if it goes away and then comes back, or if you develop itching or a rash, stop using the product and call your doctor.

If the product is swallowed, seek emergency medical help or contact a Poison Control Center immediately.

Overdose

It appears that there is no specific information available regarding overdosage for this medication. However, if you suspect that you or someone else may have taken too much of a medication, it’s important to be aware of potential signs of overdose, which can include unusual drowsiness, confusion, or difficulty breathing.

If you notice any of these symptoms, or if you are unsure whether an overdose has occurred, seek immediate medical help. You can contact your local emergency services or go to the nearest hospital. Always keep medications out of reach of children and follow the prescribed dosage to prevent any risk of overdose.

Pregnancy Use

If you are pregnant or nursing, it is important to limit your use of this medication to no more than four times a day. Always consult with your healthcare provider before using any medication during pregnancy or while breastfeeding to ensure it is safe for you and your baby. Your health and the health of your child are the top priority, so please take these precautions seriously.

Lactation Use

If you are breastfeeding, it is important to know that this medication should not be used while you are nursing. Using it during this time could pose risks to your baby. Always consult with your healthcare provider for guidance on safe medications while breastfeeding to ensure the health and well-being of both you and your infant.

Pediatric Use

It is important to note that this medication should not be used in children under 12 years old. If you are a parent or caregiver, please ensure that your child meets this age requirement before considering this treatment. Always consult with a healthcare professional if you have any questions or concerns about the appropriate use of this medication for your child.

Geriatric Use

When it comes to using this medication in older adults, there is no specific information available about dosage adjustments, safety concerns, or special precautions. This means that if you or a loved one is an older adult, it’s important to consult with a healthcare provider before starting the medication. They can help determine the best approach based on individual health needs and any other medications being taken. Always prioritize open communication with your healthcare team to ensure safe and effective treatment.

Renal Impairment

If you have kidney problems, it's important to know that the information provided does not include specific guidelines for dosage adjustments, special monitoring, or safety considerations related to renal impairment (kidney issues). This means that there are no tailored recommendations for how your treatment may need to change based on your kidney function.

Always consult your healthcare provider for personalized advice and to ensure that your treatment plan is safe and effective for your specific situation. They can help monitor your kidney health and make any necessary adjustments to your medications.

Hepatic Impairment

If you have liver problems, it's important to know that there are no specific guidelines or dosage adjustments mentioned for your condition in the available information. This means that the standard recommendations apply, and there are no special monitoring requirements or precautions outlined for patients with liver impairment.

Always consult your healthcare provider for personalized advice and to ensure that any medications you take are safe for your liver health. They can provide guidance tailored to your specific situation.

Drug Interactions

It's important to have open conversations with your healthcare provider about any medications or tests you may be taking. While there are no specific drug interactions or laboratory test interactions noted for this medication, your healthcare provider can help ensure that everything you are taking works well together and is safe for you.

Always discuss your full list of medications, including over-the-counter drugs and supplements, as well as any upcoming lab tests. This way, you can avoid any potential issues and receive the best care possible.

Storage and Handling

To ensure the best performance of your product, store it in a cool, dry place where the temperature remains below 90°F (32°C). Keeping it within this temperature range helps maintain its effectiveness and safety.

When handling the product, always ensure that your hands are clean to avoid contamination. If applicable, follow any specific instructions for use to ensure safe and effective application. Remember to dispose of any components according to local regulations to ensure safety and environmental responsibility.

Additional Information

You should use this medication only on the skin (topically) and no more than four times a day. If you are pregnant or nursing, consult your healthcare provider before use. It's important to keep the product away from children and pets. If swallowed, seek medical help or contact a Poison Control Center immediately.

For safety, do not apply the medication to your eyes, mouth, mucous membranes, or genitals, and avoid tight bandaging or using it with a heating pad. Additionally, do not combine it with other topical pain products, as this could increase the risk of side effects. Be aware that the medication may stain furniture, clothing, or bedding.

FAQ

What is DENDRACIN?

DENDRACIN, also known as Neurodendraxcin®, is a professional formula topical pain relief lotion that is dermatologically tested and hypoallergenic.

What conditions does DENDRACIN help relieve?

DENDRACIN provides temporary relief of mild pain due to muscular strain, arthritis, and simple back pain. It does not cure any disease.

How should I use DENDRACIN?

You should gently rub DENDRACIN over painful areas, shake before each use, and dry the area before contact with clothes or bedding to avoid staining.

Are there any contraindications for using DENDRACIN?

Do not use DENDRACIN on cuts or infected skin, on children under 12 years old, or if you are allergic to any ingredients, PABA, aspirin products, or sulfa.

What should I do if I experience severe pain or a rash?

Stop using DENDRACIN and consult a physician if you have severe undiagnosed pain, if pain worsens or persists for more than 7 days, or if you develop itching or a rash.

Can I use DENDRACIN if I am pregnant or nursing?

No, you should not use DENDRACIN if you are pregnant or nursing.

What are the storage instructions for DENDRACIN?

Store DENDRACIN below 90°F (32°C).

What should I do if DENDRACIN gets into my eyes?

If DENDRACIN gets into your eyes, rinse with cold water and call a doctor.

How often can I use DENDRACIN?

You should not use DENDRACIN more than 4 times daily.

Packaging Info

Below are the non-prescription pack sizes of Dendracin Neurodendraxcin (methyl salicylate, menthol and capsaicin). Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Dendracin Neurodendraxcin.
Details

Drug Information (PDF)

This file contains official product information for Dendracin Neurodendraxcin, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Description

No description information is available for the drug.

Uses and Indications

This drug is indicated for the temporary relief of mild pain associated with muscular strain, arthritis, and simple back pain. It is important to note that this medication does not cure any underlying disease.

There are no teratogenic effects associated with this drug, and no nonteratogenic effects have been reported.

Dosage and Administration

Healthcare professionals should instruct patients to use the product only as directed. Prior to the first application, it is recommended to rub a small amount on the skin to check for sensitivity. The product should be shaken well before each use to ensure proper consistency.

For application, patients should gently rub the product over the painful areas. It is important to allow the area to dry completely before coming into contact with clothing or bedding to prevent staining. After application, patients should wash their hands thoroughly to avoid unintentional transfer of the product.

Patients should not exceed four applications per day. Additionally, the product is contraindicated for use in individuals who are pregnant or nursing. In the event of accidental contact with the eyes, patients should rinse the eyes with cold water immediately and seek medical attention.

Contraindications

Use of this product is contraindicated in the following situations:

  • Application on cuts or infected skin due to the risk of exacerbating the condition.

  • Use in children under 12 years of age, as safety and efficacy have not been established in this population.

  • Application in large amounts, particularly over raw or blistered skin, which may increase the risk of adverse effects.

  • Use in individuals with known allergies to any ingredients in the formulation, including PABA, aspirin products, or sulfa, due to the potential for severe allergic reactions.

Warnings and Precautions

For external use only, this product is contraindicated for application in the eyes, mouth, mucous membranes, or genital areas. It is imperative to prevent treated skin from coming into contact with infants or pets. The application should not involve tight bandaging, nor should it be used in conjunction with heating pads or other topical pain products. Users should be aware that the product may cause staining on furniture, clothing, or bedding.

General precautions must be observed to ensure safe usage. The product should not be applied to cuts or infected skin, nor should it be used on children under 12 years of age. Caution is advised against using large amounts, particularly over raw or blistered skin. Individuals with known allergies to any ingredients, including PABA, aspirin products, or sulfa, should refrain from using this product.

Healthcare professionals should instruct patients to discontinue use and seek medical advice under certain conditions. These include experiencing severe undiagnosed pain, if pain worsens or persists beyond 7 days, if pain resolves and then recurs within a few days, or if any itching or rash develops.

In the event of accidental ingestion, immediate medical assistance should be sought, or contact with a Poison Control Center is recommended.

Side Effects

Patients using this product may experience various adverse reactions. It is important to note that this product is for external use only and should not be applied to the eyes, mouth, mucous membranes, or genital areas. Additionally, treated skin should not come into contact with infants or pets, and the area should not be tightly bandaged or used in conjunction with a heating pad or other topical pain products. Users should be aware that the product may cause staining on furniture, clothing, or bedding.

In the event of severe undiagnosed pain, or if pain worsens or persists for more than 7 days, patients are advised to stop use and consult a physician. Furthermore, if pain resolves and then recurs within a few days, or if any itching or rash occurs, medical advice should be sought.

Drug Interactions

There are currently no documented drug interactions associated with this medication. Additionally, there is no information available regarding interactions with laboratory tests. As such, no specific recommendations for dosage adjustments or monitoring are warranted at this time.

Packaging & NDC

Below are the non-prescription pack sizes of Dendracin Neurodendraxcin (methyl salicylate, menthol and capsaicin). Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Dendracin Neurodendraxcin.
Details

Pediatric Use

Pediatric patients under 12 years of age should not be administered this medication. Safety and efficacy have not been established in this population, and therefore, its use is contraindicated in children less than 12 years old.

Geriatric Use

There is no specific information available regarding the use of this medication in geriatric patients, including dosage adjustments, safety concerns, or special precautions. Healthcare providers should exercise caution when prescribing this medication to elderly patients, as individual responses may vary. Monitoring for potential adverse effects and therapeutic efficacy is recommended in this population.

Pregnancy

Pregnant patients should not use this medication more than four times daily. The safety of this medication during pregnancy has not been established, and its use is not recommended in pregnant or nursing women. Healthcare professionals should weigh the potential benefits against the risks when considering treatment options for women of childbearing potential.

Lactation

Lactating mothers are advised against the use of this medication while nursing. There is no available data on the excretion of this drug in human breast milk or its effects on breastfed infants. Therefore, caution is warranted, and alternative treatments should be considered for lactating mothers.

Renal Impairment

Patients with renal impairment have not been specifically addressed in the available prescribing information. There are no dosage adjustments, special monitoring requirements, or safety considerations outlined for individuals with reduced kidney function. Healthcare professionals should exercise caution and consider the lack of data when prescribing to this patient population.

Hepatic Impairment

There is no information available regarding the use of this medication in patients with hepatic impairment. Consequently, there are no dosage adjustments, special monitoring requirements, or precautions specified for individuals with compromised liver function. Healthcare professionals should exercise clinical judgment when considering the use of this medication in patients with liver problems, as the absence of specific guidance necessitates careful evaluation of the patient's overall health status and liver function.

Overdosage

In the absence of specific overdosage information, it is essential for healthcare professionals to remain vigilant regarding the potential for overdose with this medication. In cases where an overdose is suspected, immediate medical attention should be sought.

Healthcare providers are advised to monitor patients closely for any signs or symptoms that may indicate an overdose. These may include, but are not limited to, increased severity of known side effects, unusual behavioral changes, or any other atypical clinical manifestations.

Management of an overdose should be guided by the clinical presentation of the patient. Supportive care is paramount, and symptomatic treatment should be initiated as necessary. It is recommended that healthcare professionals consult local poison control centers or relevant toxicology resources for specific guidance on the management of overdose cases.

In summary, while specific overdosage information is not available, healthcare professionals should exercise caution, monitor for symptoms, and provide appropriate supportive care in the event of an overdose.

Nonclinical Toxicology

There is currently no available information regarding teratogenic or non-teratogenic effects associated with the substance. Additionally, no data has been provided concerning nonclinical toxicology, animal pharmacology, or toxicology.

Postmarketing Experience

Postmarketing experience has identified the following adverse reactions reported voluntarily or through surveillance programs: skin irritation, allergic reactions, and contact dermatitis. These events have been documented in the context of routine pharmacovigilance activities.

Patient Counseling

Healthcare providers should advise patients to keep the product out of reach of children and pets to prevent accidental ingestion. Instruct patients that if the product is swallowed, they should seek medical assistance or contact a Poison Control Center immediately.

Patients should be informed not to use the product on cuts or infected skin, on children under 12 years of age, or in large amounts, particularly over raw or blistered skin. Additionally, they should avoid use if they have known allergies to any of the ingredients, including PABA, aspirin products, or sulfa.

It is important to counsel patients on proper storage, recommending that they keep the product below 90°F (32°C). Patients should be advised to discontinue use and consult a physician if they experience severe undiagnosed pain, if their pain worsens or persists for more than 7 days, if pain resolves and then recurs within a few days, or if they develop itching or a rash.

Storage and Handling

The product is supplied in various package configurations, with specific NDC numbers available for identification. It is essential to store the product in a controlled environment, maintaining a temperature below 90°F (32°C) to ensure its stability and efficacy. Proper storage conditions are critical to preserving the integrity of the product throughout its shelf life.

Additional Clinical Information

The product is administered topically and should not be used more than four times daily. It is contraindicated for use in pregnant or nursing individuals. Clinicians should advise patients to keep the product away from children and pets, and to seek medical assistance or contact a Poison Control Center immediately if ingested.

Patients are cautioned that the product is for external use only and must not be applied to the eyes, mouth, mucous membranes, or genitals. Treated skin should not come into contact with infants or pets, and the area should not be tightly bandaged or used in conjunction with heating pads or other topical pain products. Additionally, the product may cause staining on furniture, clothing, or bedding.

Drug Information (PDF)

This file contains official product information for Dendracin Neurodendraxcin, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Data Generation & Sources

This page was automatically generated and is maintained by the AllDrugs AI Data-Science Team. It was built from the FDA Structured Product Label (DailyMed) for Dendracin Neurodendraxcin, retrieved by a validated AI data-extraction workflow.

All FDA-listed dosage forms and strengths are shown in the Packaging & NDC Codes section above. Regulatory status appears in the Summary Information panel above and was verified in the FDA National Drug Code directory and the NSDE NDC Directory daily file.

Note: an automated daemon monitors NSDE checksums; when the record for this NDC changes, the new file is pulled instantly and this page is refreshed.

No human clinician has reviewed this version.

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Orange Book data shown on this page are limited to Regulatory Status (Rx), Established Pharmacologic Class (EPC), and Mechanism of Action (MoA).

Regulatory data notice: Information on this page is reproduced verbatim from FDA public databases (NSDE, Orange Book, Purple Book, DailyMed SPL). NDA/ANDA drugs are FDA-approved, BLA biologics are FDA-licensed. Inclusion alone does not guarantee current market availability or imply FDA endorsement.

Medical disclaimer: This AI-generated content is provided for educational purposes only and does not constitute medical advice. Always consult a licensed healthcare professional for diagnosis or treatment decisions.