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Naphazoline hcl
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- Active ingredient
- Naphazoline Hcl 12 mg/100 mL – 0.06 g/100 mL
- Reference brand
- Sato Clear
- Dosage forms
- Liquid
- Solution/ Drops
- Spray
- Routes
- Nasal
- Ophthalmic
- Topical
- Prescription status
- OTC (over the counter)
- Marketed in the U.S.
- Since 1989
- Label revision date
- February 8, 2026
- Pregnancy
- See Pregnancy Use Section
- Lactation
- See Lactation Use Section
- Active ingredient
- Naphazoline Hcl 12 mg/100 mL – 0.06 g/100 mL
- Reference brand
- Sato Clear
- Dosage forms
- Liquid
- Solution/ Drops
- Spray
- Routes
- Nasal
- Ophthalmic
- Topical
- Prescription status
- OTC (over the counter)
- CSA schedule
- Not a scheduled drug
- Marketed in the U.S.
- Since 1989
- Label revision date
- February 8, 2026
- Pregnancy
- See Pregnancy Use Section
- Lactation
- See Lactation Use Section
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Drug Overview
Seacall Nasal Spray, along with other products like Nafasolina and Dermfree Original Nasal, is designed to provide temporary relief from nasal congestion caused by conditions such as the common cold, hay fever, or sinusitis. These medications work by helping to clear nasal passages, making it easier for you to breathe when you're experiencing stuffiness or pressure in your sinuses.
Typically available in forms like sprays or drops, these nasal treatments are effective for alleviating symptoms associated with upper respiratory allergies and sinus congestion. While the specific mechanisms of action are not detailed, their primary purpose is to relieve discomfort and improve nasal airflow.
Uses
You can use this nasal spray or drops to temporarily relieve nasal congestion caused by the common cold, hay fever, or sinusitis. It helps clear your stuffy nose and alleviates sinus congestion and pressure, making it easier for you to breathe. This product is suitable for addressing symptoms related to upper respiratory allergies as well.
Dosage and Administration
You can use nasal sprays or drops to relieve nasal congestion. For adults and children aged 12 years and older, you can apply 1 or 2 drops in each nostril every 6 hours, or use 2 to 3 sprays in each nostril every 10 to 12 hours. However, do not exceed 2 doses in a 24-hour period for sprays. If you are using a spray for the first time, remember to remove the protective cap, prime the pump by pressing it several times, and shake well before use.
For children under 12 years, consult a doctor before use. Children aged 6 years and older can use the sprays with adult supervision, but those under 6 years should not use these products. Always ensure there is at least a 4-hour interval between uses if you are applying drops, and do not use any nasal product for more than 7 consecutive days. After using a spray, wipe the nozzle clean to keep it hygienic.
What to Avoid
You should avoid using nasal sprays or solutions if you have certain medical conditions, including heart disease, high blood pressure, thyroid disease, diabetes, or if you are taking a monoamine oxidase inhibitor (MAOI) for depression or other conditions. Additionally, do not use these products in children under 2 years old or under 6 years old, depending on the specific product. It's important not to exceed the recommended dosage or use these products for more than 3 days, as prolonged use may worsen nasal congestion. If you experience any allergic reactions or if the product changes in appearance, discontinue use immediately. Always consult a healthcare professional if you are pregnant or breastfeeding.
Side Effects
You may experience some temporary discomfort when using nasal sprays or drops, such as burning, stinging, sneezing, or increased nasal discharge. It's important to note that frequent or prolonged use can lead to worsening nasal congestion. If you have heart disease, high blood pressure, thyroid disease, diabetes, or difficulty urinating due to an enlarged prostate, consult a doctor before using these products.
Additionally, do not use these products for more than three days, and avoid sharing the container with others to prevent spreading infection. If symptoms persist, or if you are pregnant or breastfeeding, seek advice from a healthcare professional. Children under 12 years of age should not use these products without medical guidance, as they may cause sedation if swallowed.
Warnings and Precautions
This nasal product is for adults only and should not be used by children under 12 years of age. If you are allergic to any of the ingredients, do not use it.
Before using, consult your doctor if you have heart disease, high blood pressure, thyroid disease, diabetes, or difficulty urinating due to an enlarged prostate. Do not exceed the recommended dosage, and do not use for more than 3 days. Frequent or prolonged use may worsen nasal congestion. Temporary discomfort such as burning, stinging, sneezing, or increased nasal discharge may occur.
Stop using the product and call your doctor if symptoms persist. In case of accidental ingestion or overdose, seek medical help or contact a Poison Control Center immediately. If you are pregnant or breastfeeding, consult a healthcare professional before use.
Overdose
If you accidentally use more of a nasal spray or drops than recommended, it's important to seek medical help immediately or contact a Poison Control Center. Signs of an overdose can vary, but you should be aware of any unusual symptoms that may arise after using the product.
To avoid potential issues, always follow the recommended dosage instructions. For products like Dermfree Original Nasal Spray, it's advised not to use them continuously for more than three days without a break, as this can lead to worsened nasal congestion. If you experience any adverse effects or have concerns about your usage, don't hesitate to reach out to a healthcare professional.
Pregnancy Use
If you are pregnant or breastfeeding, it is important to consult a healthcare professional before using nasal sprays or drops, including products like Seacall Nasal Spray, Nafasolina, and others. While some labels do not provide specific safety information or contraindications regarding their use during pregnancy, seeking advice from a healthcare provider ensures that you make informed decisions about your health and the health of your baby.
Always prioritize your safety and well-being by discussing any medications with your doctor, especially during pregnancy and breastfeeding.
Lactation Use
When considering the use of nasal sprays or drops while breastfeeding, it's important to be cautious. The safety of these products for nursing mothers has not been fully established, and there is a potential for the ingredients to pass into breast milk, which means their effects on your infant are unknown. Therefore, it is advisable to consult a healthcare professional before using any of these products if you are pregnant or breastfeeding.
Always prioritize your health and your baby's well-being by seeking guidance from a healthcare provider regarding any medications or treatments during lactation.
Pediatric Use
You should be cautious when using nasal sprays and solutions for children. Many products are not recommended for young children. For example, do not use Seacall Nasal Spray in children, and avoid Nafasolina in those under 12 years unless directed by a doctor, as it may cause sedation if swallowed.
For nasal sprays like Skapemed Original, Serynth Fast Relief, and Natuheal Original, they should not be used in children under 2 years, and you should consult a doctor for children aged 2 to under 6 years. For children 6 years and older, these products can be used with adult supervision, allowing 2 or 3 sprays in each nostril every 10 to 12 hours, but do not exceed 2 doses in 24 hours. Additionally, Dermfree Original Nasal should not be used in children under 6 years, and a doctor's advice is needed for those aged 6 to under 12 years. Always keep these products out of reach of children and seek medical help if ingested.
Geriatric Use
If you are an older adult or a caregiver, it's important to be cautious when using nasal sprays. Some products, like Seacall Nasal Spray, are specifically for adults and should not be used if you have conditions such as high blood pressure, heart disease, hyperthyroidism (an overactive thyroid), or allergies. Always consult your doctor before using these sprays if you have any of these health issues.
For other nasal sprays like Nafasolina, Skapemed Original Nasal, Natuheal Original Nasal, Serynth Fast Relief Nasal, and Dermfree Original Nasal, there is no specific information regarding their use in older adults, including any necessary dosage adjustments or safety concerns. However, Dermfree Original Nasal does recommend consulting a doctor if you have heart disease, high blood pressure, thyroid disease, diabetes, or difficulty urinating due to an enlarged prostate. Always follow the recommended dosage and consult your healthcare provider for personalized advice.
Renal Impairment
When using nasal sprays or drops, it's important to note that the available information does not specify any dosage adjustments, monitoring, or safety considerations for individuals with kidney problems. This includes products like Seacall Nasal Spray, Nafasolina, Dermfree Original Nasal, Skapemed Original Nasal, Natuheal Original Nasal, Serynth Fast Relief Nasal, Nazal, and Sato Clear. If you have kidney issues, it's advisable to consult your healthcare provider for personalized guidance before using these products.
Hepatic Impairment
You may be wondering about the safety of using certain nasal sprays and solutions if you have liver issues. The products listed, including Seacall Nasal Spray, Nafasolina, Dermfree Original Nasal, Skapemed Original Nasal, Natuheal Original Nasal, Serynth Fast Relief Nasal, and Nazal, do not provide specific information regarding liver impairment. This means there are no dosage adjustments, special monitoring, or precautions mentioned for individuals with liver problems.
If you have liver concerns, it's always best to consult with your healthcare provider before using any new medication to ensure it is safe for you.
Drug Interactions
When using nasal sprays or drops like Seacall, Nafasolina, Skapemed Original Nasal, Natuheal Original Nasal, Serynth Fast Relief Nasal, and Dermfree Original Nasal, it's important to note that there are no specific drug interactions or laboratory test interactions reported for these products. This means that, based on current information, they are not known to interfere with other medications or tests.
However, it's always a good idea to discuss any medications or treatments you are using with your healthcare provider. They can provide personalized advice and ensure that your overall treatment plan is safe and effective, especially if you are taking other medications or have underlying health conditions.
Storage and Handling
To ensure the best quality and effectiveness of your nasal spray or drops, store them in a cool, dry place away from light, ideally at temperatures between 20°C to 25°C (68°F to 77°F). Make sure to keep the product sealed and out of reach of children. After opening, it's important to discard the product as directed, and always retain the original box for reference on labeling and instructions.
Before use, check that the tamper-resistant seal on the bottle cap is intact. If the seal is broken, do not use the product. Remember to keep the container tightly closed when not in use to maintain its effectiveness.
FAQ
What is the primary use of these nasal sprays?
These nasal sprays temporarily relieve nasal congestion due to a cold, hay fever, or other upper respiratory allergies, as well as sinus congestion and pressure.
What is the recommended dosage for adults and children 6 years and older?
For adults and children 6 years and older, the recommended dosage is 2 or 3 sprays in each nostril, not more often than every 10 to 12 hours, and do not exceed 2 doses in 24 hours.
Can children under 12 years use these products?
No, these products should not be used in children under 12 years unless directed by a doctor.
What should I do if symptoms persist?
If symptoms persist, you should stop using the product and ask a doctor for advice.
What are some possible side effects of these nasal sprays?
You may experience temporary discomfort such as burning, stinging, sneezing, or increased nasal discharge.
How long can I use these nasal sprays?
You should not use these products for more than 3 days, as frequent or prolonged use may cause nasal congestion to recur or worsen.
What precautions should I take before using these nasal sprays?
Ask a doctor before use if you have heart disease, high blood pressure, thyroid disease, diabetes, or trouble urinating due to an enlarged prostate gland.
What should I do if I accidentally swallow the nasal spray?
If swallowed, get medical help or contact a Poison Control Center right away.
Is it safe to use these nasal sprays during pregnancy or breastfeeding?
If you are pregnant or breastfeeding, you should ask a health professional before using these products.
What should I avoid while using these nasal sprays?
Avoid contact with the eyes, do not exceed the recommended dosage, and do not share the container with others to prevent spreading infection.
Uses and Indications
This drug is indicated for the temporary relief of nasal congestion due to the common cold, hay fever, or other upper respiratory allergies. It also provides temporary relief of sinus congestion and pressure.
Limitations of Use No teratogenic or nonteratogenic effects are mentioned for this drug.
Dosage and Administration
Adults and children 12 years of age and older are recommended to use 1 or 2 drops or 2 to 3 sprays in each nostril, not more often than every 6 hours for drops or every 10 to 12 hours for sprays. The maximum frequency for nasal spray administration is not to exceed 2 doses in a 24-hour period. For nasal spray formulations, it is advised to shake well before use and to prime the metered pump by firmly depressing it several times before the first use.
For children under 12 years of age, administration should only occur under the direction of a healthcare professional. Specifically, children aged 6 to under 12 years should consult a doctor before use, and nasal sprays are not recommended for children under 6 years.
When administering the nasal spray, the healthcare professional should instruct the patient to hold the bottle with the thumb at the base and the nozzle between the first and second fingers. The nozzle should be inserted into the nostril without tilting the head, and the pump should be fully depressed with a firm, even stroke while the patient sniffs deeply. After use, the nozzle should be wiped clean.
It is important to ensure that no more than 4 doses are administered in a single day, with an interval of at least 4 hours between each use for those using drops. Continuous use of nasal sprays should not exceed 7 days.
Contraindications
Do not use in children under 2 years of age or in children under 6 years of age, as it may cause sedation if swallowed. Use is contraindicated in patients with atrophic rhinitis, nasal dryness, heart disease, high blood pressure, thyroid disease, diabetes, or difficulty in urination due to prostate enlargement unless directed by a doctor. Additionally, do not use if currently taking a prescription monoamine oxidase inhibitor (MAOI) or within 2 weeks of stopping such medication.
Use is also contraindicated if there is an allergy to any of the ingredients or if the product's character changes, such as color or cloudiness. The product should not be used without nasal congestion. Frequent or prolonged use may lead to a recurrence or worsening of nasal congestion.
Warnings and Precautions
For Adults Only This product is intended for adult use only. The use of this container by more than one person may spread infection.
Warnings
Do not use if allergic to any of the ingredients.
Ask a doctor before use if the individual has:
Heart disease
High blood pressure
Thyroid disease
Diabetes
Trouble urinating due to enlarged prostate gland
Do not use in children under 12 years of age, as it may cause sedation if swallowed.
For external use only.
General Precautions
Do not exceed the recommended dosage.
Do not use this product for more than 3 days. Frequent or prolonged use may cause nasal congestion to recur or worsen.
Temporary discomfort such as burning, stinging, sneezing, or increased nasal discharge may occur.
Avoid contact with the eyes; in case of contact, rinse eyes thoroughly with water.
If pregnant or breastfeeding, consult a healthcare professional before use.
Stop Taking and Call Your Doctor
Stop use and ask a doctor if symptoms persist or worsen.
If experiencing hypertension, coronary heart disease, hyperthyroidism, or allergic reactions, discontinue use and consult a doctor.
Get Emergency Medical Help
In case of accidental ingestion or overdose, get medical help or contact a Poison Control Center immediately.
If swallowed, seek medical assistance right away.
Monitoring Requirements
No specific laboratory tests are mentioned; however, individuals with pre-existing conditions should be monitored closely while using this product.
Side Effects
Patients using nasal sprays may experience a range of adverse reactions, which can vary in severity and frequency. The following summarizes the potential adverse reactions based on available data from multiple product labels.
Serious Adverse Reactions
Allergic Reactions: Patients should not use these products if they are allergic to any of the ingredients.
Cardiovascular Concerns: Patients with heart disease, high blood pressure, or thyroid disease should consult a doctor before use.
Urinary Issues: Those with difficulty urinating due to an enlarged prostate gland should seek medical advice prior to use.
Common Adverse Reactions
Temporary Discomfort: Patients may experience burning, stinging, sneezing, or increased nasal discharge during use.
Nasal Congestion: Frequent or prolonged use may lead to a recurrence or worsening of nasal congestion.
Warnings and Precautions
Use Limitations: These products should not be used for more than three consecutive days to avoid rebound congestion.
Age Restrictions: Some products are not recommended for use in children under 12 years of age due to potential sedation if swallowed.
Infection Risk: The use of these containers by more than one person may spread infection.
Recommendations for Use
Patients are advised to stop using the product and consult a doctor if symptoms persist or worsen.
Pregnant or breastfeeding individuals should seek professional advice before using these products.
Additional Notes
In the event of accidental overdose, patients should seek immediate medical assistance or contact a Poison Control Center.
This summary highlights the importance of adhering to usage guidelines and consulting healthcare professionals when necessary to mitigate risks associated with nasal spray use.
Drug Interactions
All reviewed nasal spray and solution products, including Seacall Nasal Spray, Nafasolina, Skapemed Original Nasal, Natuheal Original Nasal, Serynth Fast Relief Nasal, and Dermfree Original Nasal, have not provided any information regarding drug interactions.
No interactions with other drugs or laboratory tests have been documented for these products. Therefore, healthcare professionals should be aware that there is currently no available data on potential drug interactions associated with these nasal formulations.
Pediatric Use
Pediatric patients should be carefully evaluated before using nasal spray products, as age restrictions and specific cautions apply.
Efficacy and Dosing
Children 6 years and older: For products indicated for this age group, the recommended dosage is 2 or 3 sprays in each nostril, not more often than every 10 to 12 hours, with a maximum of 2 doses in 24 hours. Adult supervision is required.
Children 2 to under 6 years: Consultation with a doctor is advised before use.
Children under 2 years: Use is contraindicated for several products.
Safety
Children under 12 years: Certain products should not be administered unless directed by a doctor, as they may cause sedation if swallowed.
Specific Health Conditions: Products should not be used in children with heart disease, high blood pressure, thyroid disease, or diabetes unless directed by a healthcare provider.
Accidental Ingestion: All products should be kept out of reach of children. In case of accidental ingestion, medical help or contact with a poison control center is recommended.
Contraindications
Children under 6 years: Some products are not recommended for this age group without prior medical advice.
Geriatric Use
Elderly patients may be at increased risk for adverse effects when using nasal sprays, particularly those with underlying health conditions. For Seacall Nasal Spray, it is advised that elderly patients consult a healthcare provider prior to use if they have hypertension, coronary heart disease, hyperthyroidism, or allergies.
No specific information regarding dosage adjustments, safety concerns, or special precautions for geriatric patients is available for Nafasolina, Skapemed Original Nasal, Natuheal Original Nasal, Serynth Fast Relief Nasal, and Dermfree Original Nasal. Therefore, healthcare providers should exercise caution when prescribing these products to elderly patients, considering their overall health status and potential for increased sensitivity to medications.
For Dermfree Original Nasal, it is recommended that elderly patients seek medical advice if they have heart disease, high blood pressure, thyroid disease, diabetes, or urinary issues related to an enlarged prostate. The standard dosing for adults and children aged 12 years and older is 2 or 3 sprays in each nostril, not exceeding 2 doses in 24 hours, with adult supervision advised for children.
Overall, careful monitoring and consideration of individual patient factors are essential when treating geriatric patients with nasal sprays.
Pregnancy
Pregnant patients should exercise caution when considering the use of nasal products, as specific information regarding the safety and efficacy of these formulations during pregnancy is limited.
For Seacall Nasal Spray and Skapemed Original Nasal, there are no explicit contraindications or safety concerns mentioned in their respective inserts regarding use during pregnancy. However, the absence of data does not imply safety, and healthcare professionals should be consulted.
Nafasolina, Natuheal Original Nasal, Serynth Fast Relief Nasal, Dermfree Original Nasal, and Nazal all recommend that pregnant or breastfeeding patients consult a healthcare professional prior to use. This precaution underscores the importance of individualized assessment and guidance from a healthcare provider to ensure the safety of both the patient and the fetus.
In summary, while some products do not provide specific warnings, the general recommendation is for pregnant patients to seek professional advice before using nasal formulations.
Lactation
The safety of various nasal spray products during lactation has not been fully established. Caution is advised when administering these products to lactating mothers, as there is a potential for excretion in breast milk, although the specific effects on breastfed infants remain unknown.
Healthcare professionals recommend that nursing mothers consult with a healthcare provider before using any nasal spray or solution, particularly if they are pregnant or breastfeeding. This guidance applies to products such as Seacall Nasal Spray, Nafasolina, and others, which lack specific lactation data.
In summary, while some products indicate a need for consultation prior to use during breastfeeding, the overall lack of detailed information necessitates careful consideration and professional guidance to ensure the safety of both the mother and the infant.
Renal Impairment
Patients with renal impairment may not have specific dosing adjustments, monitoring requirements, or safety considerations outlined for the following nasal spray and solution products: Seacall Nasal Spray, Nafasolina, Dermfree Original Nasal, Skapemed Original Nasal, Natuheal Original Nasal, Serynth Fast Relief Nasal, and Nazal.
The available product inserts do not provide information regarding the impact of reduced kidney function on the pharmacokinetics or pharmacodynamics of these medications. Consequently, healthcare professionals should exercise caution when prescribing these products to patients with renal impairment, as the lack of data necessitates careful consideration of potential risks and benefits.
It is advisable for clinicians to monitor patients closely for any adverse effects or changes in therapeutic response when these products are administered to individuals with compromised renal function.
Hepatic Impairment
Patients with hepatic impairment have not been specifically addressed in the product inserts for the following medications: Seacall Nasal Spray, Nafasolina, Dermfree Original Nasal Spray, Skapemed Original Nasal Liquid, Natuheal Original Nasal Spray, Serynth Fast Relief Nasal Spray, Nazal Liquid, and Sato Clear Solution/Drops.
There is no information provided regarding dosage adjustments, special monitoring, or precautions for this patient population. Therefore, healthcare professionals should exercise caution and consider individual patient factors when prescribing these medications to patients with liver problems.
Overdosage
In the event of an overdose, it is crucial to seek immediate medical assistance or contact a Poison Control Center. While specific symptoms of overdose are not detailed for most products, it is advised to adhere strictly to the recommended dosages to prevent adverse effects.
For products such as Nazal, in case of accidental overdose, prompt medical help is essential. Continuous use of nasal sprays, such as Dermfree Original Nasal, should not exceed the recommended duration, as prolonged use may lead to worsening nasal congestion. It is recommended to take a break after three consecutive days of use.
Healthcare professionals should monitor patients for any signs of adverse reactions or worsening symptoms, particularly in cases of misuse or excessive dosage.
Nonclinical Toxicology
Teratogenic Effects
No information is available regarding teratogenic effects for any of the products evaluated.
Non-Teratogenic Effects
No information is available regarding non-teratogenic effects for any of the products evaluated.
Nonclinical Toxicology Section
No information is provided in the nonclinical toxicology sections for any of the products evaluated.
Animal Pharmacology and Toxicology
No information is available regarding animal pharmacology and toxicology for any of the products evaluated.
Storage and Handling
Seacall Nasal Spray is supplied as a spray and should be shielded from light, sealed, and stored in a cool place, not exceeding 20°C.
Nafasolina is available in solution/drops form and must be stored at temperatures between 20°C to 25°C (68°F to 77°F). It should be protected from light, kept out of reach of children, and discarded after opening.
Dermfree Original Nasal is provided as a spray and should not exceed 25°C. The box should be retained for future reference on full labeling.
Skapemed Original Nasal is supplied as a liquid and should also not exceed 25°C. The box should be retained for future reference on full labeling.
Natuheal Original Nasal is available as a spray and should be stored at temperatures between 20°C to 25°C (68°F to 77°F).
Serynth Fast Relief Nasal is supplied as a spray and should not exceed 25°C.
Nazal is provided as a liquid, and the container is filled to the proper level for optimal spray action.
Sato Clear is available in solution/drops form and should only be used if the imprinted tamper-resistant seal on the bottle cap is intact. The container must be kept tightly closed.
Product Labels
The table below lists all over-the-counter labels containing naphazoline hcl. Use it to compare dosage forms, strengths, and uses across products.
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Jiangxi Yudexi Pharmaceutical Co. , LTD | Spray | Nasal | 0.05 g/100 mL | 2025 | |
Indications
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Jiangxi Yudexi Pharmaceutical Co. , LTD | Spray | Nasal | 0.05 g/100 mL | 2026 | |
Indications
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Jiangxi Yudexi Pharmaceutical Co. , LTD | Spray | Nasal | 0.05 g/100 mL | 2026 | |
Indications
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Doral Pharmamedics Inc DBA AG Marin Pharmaceuticals | Solution/ Drops | Nasal | 50 mg/100 mL | 2025 | |
Indications
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Jiangxi Yudexi Pharmaceutical Co. , LTD | Spray | Nasal | 0.05 g/100 mL | 2026 | |
Indications
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Sato Pharmaceutical Co. , Ltd. | Liquid | Nasal | 50 mg/100 mL | 1990 | |
Indications
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Sato Pharmaceutical Co. , Ltd. | Solution/ Drops | Ophthalmic | 12 mg/100 mL | 1989 | |
Indications
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Guangdong Quadrant Ecological Technology Co. , Ltd. | Spray | Topical | 0.06 g/100 mL | 2024 | |
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Jiangxi Yudexi Pharmaceutical Co. , LTD | Spray | Nasal | 0.05 g/100 mL | 2026 | |
Indications
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Jiangxi Yudexi Pharmaceutical Co. , LTD | Liquid | Nasal | 0.05 g/100 mL | 2026 | |
Indications
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