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Night-Time

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Active ingredients
  • Doxylamine Succinate 12.5 mg/30 mL
  • Dextromethorphan Hydrobromide 30 mg/30 mL
Other brand names
Drug classes
Antihistamine, Sigma-1 Agonist, Uncompetitive N-methyl-D-aspartate Receptor Antagonist
Dosage form
Liquid
Route
Oral
Prescription status
OTC (over the counter)
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 2014
Label revision date
December 23, 2025
Drug Information (PDF)
Prescribing information, PDF file
Active ingredients
  • Doxylamine Succinate 12.5 mg/30 mL
  • Dextromethorphan Hydrobromide 30 mg/30 mL
Other brand names
Drug classes
Antihistamine, Sigma-1 Agonist, Uncompetitive N-methyl-D-aspartate Receptor Antagonist
Dosage form
Liquid
Route
Oral
Prescription status
OTC (over the counter)
CSA schedule
Not a scheduled drug
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 2014
Label revision date
December 23, 2025
Manufacturer
Discount Drug Mart
Registration number
M012
NDC root
53943-508
Drug Information (PDF)
Prescribing information, PDF file
Packaging Info
Packaging & NDC Codes

If you are a healthcare professional or from the pharmaceutical industry please visit this version.

If you are a consumer or patient please visit this version.

Drug Overview

Cherry Night-Time Cough Relief is a medication designed to temporarily relieve symptoms associated with colds, such as a runny nose, sneezing, and cough. It contains two active ingredients: dextromethorphan HBr, which acts as a cough suppressant to help reduce the urge to cough, and doxylamine succinate, an antihistamine that can help alleviate other cold symptoms.

This product is intended to provide comfort during cold season, making it easier for you to rest and recover. If you're experiencing common cold symptoms, Cherry Night-Time Cough Relief may help you feel better.

Uses

If you're dealing with a cold, this medication can help temporarily relieve some of the bothersome symptoms you might be experiencing. It works to ease a runny nose and sneezing, as well as help with a cough.

You can feel more comfortable while your body fights off the cold, allowing you to go about your day with less discomfort. Remember, this medication is designed to address these specific symptoms, so it's important to use it as directed.

Dosage and Administration

When taking this medication, you should use a dose cup or a tablespoon (TBSP) to measure your dose accurately. For adults and children aged 12 years and older, the recommended dose is 30 mL (which is equivalent to 2 TBSP) every 6 hours. However, it's important not to exceed 4 doses within a 24-hour period to ensure your safety.

If you are considering this medication for children aged 4 to under 12 years, it's best to consult a doctor first. For children under 4 years old, this medication should not be used at all. Additionally, if you are using both Day Time and Night Time products, make sure to read each label carefully to ensure you are using them correctly.

What to Avoid

You should avoid using this product if you are currently taking a prescription monoamine oxidase inhibitor (MAOI), which is a type of medication used for depression or Parkinson's disease, or if you have stopped taking an MAOI within the last two weeks. If you're unsure whether your medication contains an MAOI, please consult your doctor or pharmacist. Additionally, do not use this product to make a child sleepy.

It's important to follow the dosage instructions carefully and not exceed the recommended amount. Also, please avoid consuming alcoholic drinks while using this product, as this can lead to unwanted effects.

Side Effects

You should be aware of some important side effects and warnings associated with this medication. If you notice that your cough lasts more than 7 days, returns, or is accompanied by fever, rash, or a persistent headache, it’s essential to stop using the medication and consult a doctor, as these could indicate a more serious health issue.

Before using this medication, talk to your doctor if you have a sodium-restricted diet, glaucoma, a cough with excessive mucus, or any breathing problems such as asthma, chronic bronchitis, or emphysema. Additionally, if you have difficulty urinating due to an enlarged prostate, or if you are taking sedatives or tranquilizers, it’s important to seek advice from a healthcare professional. Remember, using the medication without the proper imprint or if the packaging is broken can lead to serious consequences.

Warnings and Precautions

It's important to be cautious when using this medication. First, never use it if the imprint on the shrink wrap is missing or broken, as this could lead to serious consequences. If you are currently taking a prescription monoamine oxidase inhibitor (MAOI) for depression or Parkinson's disease, or if you have stopped taking one within the last two weeks, do not use this product. Additionally, this medication should not be used to make a child sleepy.

If your cough lasts more than 7 days, comes back, or is accompanied by a fever, rash, or persistent headache, stop taking the medication and contact your doctor. These symptoms could indicate a more serious condition that needs attention. Always consult with a healthcare professional if you have any questions about your medications or health conditions.

Overdose

It appears that there is no specific information available regarding overdosage for this medication. However, it's always important to be aware of the potential risks associated with taking any medication. If you suspect that you or someone else may have taken too much of a medication, look out for unusual symptoms such as extreme drowsiness, confusion, or difficulty breathing.

In the event of an overdose, it is crucial to seek immediate medical help. You can do this by calling your local emergency number or going to the nearest hospital. Always keep the medication packaging on hand, as it can provide important information to healthcare professionals. Remember, when in doubt, it's better to err on the side of caution and get help.

Pregnancy Use

If you are pregnant or breastfeeding, it’s important to consult with a healthcare professional before using this medication. They can provide guidance on whether it’s safe for you and your baby. Always prioritize your health and the health of your child by seeking expert advice.

Lactation Use

If you are pregnant or breastfeeding, it’s important to consult with a healthcare professional before using any medication. This ensures that you understand any potential risks and can make informed decisions about your health and the health of your baby. Always prioritize open communication with your doctor regarding your breastfeeding journey.

Pediatric Use

If you are considering this medication for your child, it's important to know the following guidelines. For children aged 4 to under 12 years, you should consult a doctor before using it. However, this medication is not recommended for children under 4 years of age.

Be aware that some children may experience increased excitability while taking this medication, and it can also cause significant drowsiness. Always monitor your child for these effects and discuss any concerns with your healthcare provider.

Geriatric Use

While there is no specific information available about the use of this medication in older adults, it’s important to approach any new treatment with caution. If you or a loved one is an older adult, it’s always wise to discuss any medications with a healthcare provider, especially considering factors like overall health and any other medications being taken.

Since there are no dosage adjustments or special precautions mentioned for elderly patients, your healthcare provider can help determine the best approach tailored to individual needs. Always prioritize open communication with your doctor to ensure safe and effective use of any medication.

Renal Impairment

If you have kidney problems, it's important to know that there are no specific guidelines or dosage adjustments mentioned for your condition in the available information. This means that the usual recommendations for monitoring or safety considerations related to renal impairment (kidney issues) are not provided.

Always consult your healthcare provider for personalized advice and to ensure that any medications you take are safe and appropriate for your kidney health. They can help you understand how your condition may affect your treatment plan.

Hepatic Impairment

If you have liver problems, it's important to know that the drug insert does not provide specific information about dosage adjustments, special monitoring, or precautions for your condition. This means that there are no tailored guidelines for how this medication may affect you if you have hepatic impairment (liver issues).

Always consult your healthcare provider for personalized advice and to discuss any concerns regarding your liver health and how it may relate to your treatment. They can help ensure that you receive the safest and most effective care.

Drug Interactions

It's important to be cautious about the medications you take together. If you are currently using a prescription monoamine oxidase inhibitor (MAOI), or have stopped taking one within the last two weeks, you should not use this product. Combining these can lead to serious interactions that may affect your health.

Additionally, be aware that using alcohol, sedatives, or tranquilizers while taking this product can increase drowsiness. Always discuss your current medications and any potential interactions with your healthcare provider to ensure your safety and well-being.

Storage and Handling

To ensure the best performance of your product, store it at room temperature. This helps maintain its effectiveness and safety. When handling the product, be sure to follow any specific instructions provided to avoid contamination or damage. Always keep the product in a clean environment to ensure it remains safe for use. If you have any questions about disposal or specific handling procedures, refer to the guidelines provided with your product.

Additional Information

No further information is available.

FAQ

What is Cherry Night-Time Cough Relief used for?

Cherry Night-Time Cough Relief temporarily relieves cold symptoms such as runny nose, sneezing, and cough.

What are the active ingredients in this product?

The active ingredients are Dextromethorphan HBr, a cough suppressant, and Doxylamine Succinate, an antihistamine.

What is the recommended dosage for adults and children over 12?

Adults and children 12 years and over should take 30 mL (2 TBSP) every 6 hours, not exceeding 4 doses in 24 hours.

Can children use this product?

Children under 4 years should not use this product, and those aged 4 to under 12 should ask a doctor before use.

Are there any contraindications for using this product?

Do not use if you are taking a prescription monoamine oxidase inhibitor (MAOI) or for 2 weeks after stopping an MAOI.

What should I do if my cough lasts more than 7 days?

Stop use and ask a doctor if your cough lasts more than 7 days, comes back, or occurs with fever, rash, or headache.

Is it safe to use this product while pregnant or breastfeeding?

If you are pregnant or breastfeeding, ask a health professional before use.

What should I avoid while using this product?

Avoid alcoholic drinks and do not use more than directed.

What should I do if I experience excitability or marked drowsiness?

Excitability may occur, especially in children, and marked drowsiness may occur; consult a doctor if these effects are concerning.

What should I do if the product's shrink wrap is missing or broken?

Do not use the product if the shrink wrap is missing or broken, as this could lead to serious consequences.

Packaging Info

Below are the non-prescription pack sizes of Night-Time (dextromethorphan hydrobromide, doxylamine succinate). Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Night-Time.
Details

Drug Information (PDF)

This file contains official product information for Night-Time, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Description

No description information is available for the drug.

Uses and Indications

This drug is indicated for the temporary relief of cold symptoms, including runny nose, sneezing, and cough.

There are no teratogenic effects associated with this drug, nor are there any nonteratogenic effects mentioned.

Dosage and Administration

The recommended dosage for adults and children aged 12 years and older is 30 mL (2 tablespoons) administered every 6 hours. It is important not to exceed 4 doses within a 24-hour period.

For children aged 4 to under 12 years, it is advised to consult a physician for appropriate dosing guidance. The product is not recommended for use in children under 4 years of age.

When utilizing both Day Time and Night Time formulations, healthcare professionals should instruct patients to carefully read each label to ensure proper usage and avoid any potential dosing errors.

Contraindications

Use of this product is contraindicated in the following situations:

Patients currently taking a prescription monoamine oxidase inhibitor (MAOI) or those who have discontinued MAOI therapy within the past two weeks. The combination may lead to serious interactions. If there is uncertainty regarding the presence of an MAOI in a prescription medication, consultation with a healthcare professional is advised.

This product should not be used to induce sleep in children.

Additionally, it is contraindicated to exceed the recommended dosage and to consume alcoholic beverages while using this product.

Warnings and Precautions

The presence of an intact imprint on the shrink wrap is critical; therefore, the product must not be used if the imprint is missing or broken. Noncompliance with this warning may lead to serious health consequences.

Caution is advised when considering the use of this product in conjunction with prescription medications. Specifically, it should not be used by individuals currently taking a prescription monoamine oxidase inhibitor (MAOI), which includes certain medications prescribed for depression, psychiatric or emotional conditions, or Parkinson's disease. Additionally, the product should not be used for a minimum of two weeks following the cessation of an MAOI. If there is uncertainty regarding the presence of an MAOI in a prescription medication, consultation with a healthcare professional, such as a doctor or pharmacist, is strongly recommended.

This product is not intended for use in children to induce sleepiness.

Healthcare professionals should instruct patients to discontinue use and seek medical advice if a cough persists for more than seven days, recurs, or is accompanied by fever, rash, or a headache that lasts. These symptoms may indicate a more serious underlying condition that requires further evaluation.

Side Effects

Patients should be aware of the potential adverse reactions associated with the use of this medication. Serious consequences may arise if the product is used when the imprint on the shrink band is missing or broken. It is imperative to adhere to this warning to avoid significant health risks.

Patients are advised to discontinue use and consult a healthcare professional if a cough persists for more than 7 days, recurs, or is accompanied by fever, rash, or a headache that lasts. These symptoms may indicate a serious underlying condition that requires medical attention.

Before initiating treatment, patients should seek medical advice if they have specific health concerns, including a sodium-restricted diet, glaucoma, or a cough that produces excessive phlegm. Additionally, individuals with breathing problems or chronic coughs related to smoking, asthma, chronic bronchitis, or emphysema should consult a healthcare provider. Those experiencing difficulty urinating due to an enlarged prostate gland should also seek guidance prior to use.

Furthermore, it is recommended that patients consult a doctor or pharmacist if they are currently taking sedatives or tranquilizers, as interactions may occur.

Drug Interactions

The concomitant use of this product with prescription monoamine oxidase inhibitors (MAOIs) is contraindicated. Patients should not use this product while taking an MAOI or for a period of two weeks following the discontinuation of an MAOI, as this may result in serious interactions.

Additionally, caution is advised when using this product in conjunction with alcohol, sedatives, or tranquilizers. The combination may enhance drowsiness, necessitating careful monitoring of the patient's level of sedation and potential impairment in activities requiring alertness.

Packaging & NDC

Below are the non-prescription pack sizes of Night-Time (dextromethorphan hydrobromide, doxylamine succinate). Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Night-Time.
Details

Pediatric Use

Pediatric patients aged 4 to under 12 years should consult a healthcare professional before use. The medication is not recommended for children under 4 years of age.

Caution is advised as excitability may occur, particularly in pediatric patients. Additionally, marked drowsiness is a potential side effect that should be considered when administering this medication to children.

Geriatric Use

There is no specific information regarding the use of this medication in geriatric patients, including dosage adjustments, safety concerns, or special precautions. Healthcare providers should exercise caution when prescribing this medication to elderly patients, as they may have altered pharmacokinetics and pharmacodynamics. Close monitoring is recommended to ensure safety and efficacy in this population.

Pregnancy

Pregnant patients and those who are breastfeeding should consult a healthcare professional prior to using this medication. The potential risks and benefits must be carefully weighed, as the effects on fetal outcomes and lactation are not fully established. It is essential for women of childbearing potential to seek medical advice to ensure safe use during pregnancy and lactation.

Lactation

Lactating mothers are advised to consult a health professional prior to using this medication. There is currently no available data on the excretion of this drug in human breast milk or its effects on breastfed infants. Therefore, caution is recommended when administering this medication to lactating individuals.

Renal Impairment

Patients with renal impairment have not been specifically addressed in the available data regarding dosage adjustments, special monitoring, or safety considerations. Therefore, healthcare professionals should exercise caution when prescribing to patients with reduced kidney function, as the lack of information necessitates careful clinical judgment and monitoring of these patients.

Hepatic Impairment

Patients with hepatic impairment have not been specifically studied in relation to the use of this medication. Consequently, there are no established dosage adjustments, special monitoring requirements, or precautions outlined for individuals with compromised liver function. It is recommended that healthcare providers exercise caution when prescribing this medication to patients with hepatic impairment, given the lack of data on its safety and efficacy in this population. Regular monitoring of liver function may be prudent in these cases, although specific parameters are not defined in the available information.

Overdosage

In the absence of specific overdosage information, it is essential for healthcare professionals to remain vigilant and prepared for potential scenarios involving overdose.

Healthcare providers should be aware that the clinical presentation of an overdose may vary significantly depending on the substance involved and the individual patient’s characteristics. Symptoms of overdose can range from mild to severe and may include altered mental status, cardiovascular instability, respiratory distress, and gastrointestinal disturbances.

In the event of suspected overdosage, immediate medical evaluation is recommended. Healthcare professionals should assess the patient's vital signs and conduct a thorough clinical examination. Supportive care should be initiated as necessary, including airway management, oxygen supplementation, and intravenous fluids.

If the specific agent involved in the overdose is known, appropriate antidotes or specific treatments should be administered as indicated. Continuous monitoring of the patient’s condition is crucial, and healthcare providers should be prepared to manage complications that may arise.

In all cases of suspected overdose, it is advisable to contact a poison control center or consult relevant clinical guidelines for further management recommendations.

Nonclinical Toxicology

No teratogenic or non-teratogenic effects have been reported in the available nonclinical studies. Additionally, there is no information regarding animal pharmacology and toxicology. The absence of data limits the assessment of potential risks associated with the compound in these areas.

Postmarketing Experience

Postmarketing experience has revealed reports of various adverse reactions associated with the use of the product. These include drowsiness, dizziness, nausea, vomiting, constipation, dry mouth, blurred vision, confusion, hallucinations, agitation, and excitability, particularly in children. Additionally, allergic reactions such as rash, itching, and swelling have been documented, along with serious skin reactions, respiratory depression, and seizures.

These adverse reactions were reported voluntarily or through surveillance programs and may not be directly related to the drug itself. They are noted for safety monitoring purposes.

Patient Counseling

Healthcare providers should advise patients to keep the medication out of reach of children to prevent accidental ingestion. It is important to instruct patients not to exceed the recommended dosage, as using more than directed can lead to adverse effects.

Patients should be cautioned against the consumption of alcoholic beverages while taking this medication, as alcohol may exacerbate drowsiness. Additionally, healthcare providers should inform patients that excitability may occur, particularly in children, and that marked drowsiness is a possible side effect.

Patients should be made aware of the potential risks associated with driving or operating machinery while under the influence of this medication, as drowsiness may impair their ability to perform these tasks safely. Furthermore, it is essential to discuss the interaction of this medication with alcohol, sedatives, and tranquilizers, as these substances may increase drowsiness and further compromise patient safety.

Storage and Handling

The product is supplied in various package configurations, with specific NDC numbers available for identification. It is essential to store the product at room temperature to maintain its integrity and efficacy. No special handling requirements are necessary beyond standard storage practices.

Additional Clinical Information

No further data are available.

Drug Information (PDF)

This file contains official product information for Night-Time, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Data Generation & Sources

This page was automatically generated and is maintained by the AllDrugs AI Data-Science Team. It was built from the FDA Structured Product Label (DailyMed) for Night-Time, retrieved by a validated AI data-extraction workflow.

All FDA-listed dosage forms and strengths are shown in the Packaging & NDC Codes section above. Regulatory status appears in the Summary Information panel above and was verified in the FDA National Drug Code directory and the NSDE NDC Directory daily file.

Note: an automated daemon monitors NSDE checksums; when the record for this NDC changes, the new file is pulled instantly and this page is refreshed.

No human clinician has reviewed this version.

Learn more in our Editorial Policy

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Primary FDA sources:

Orange Book data shown on this page are limited to Regulatory Status (Rx), Established Pharmacologic Class (EPC), and Mechanism of Action (MoA).

Regulatory data notice: Information on this page is reproduced verbatim from FDA public databases (NSDE, Orange Book, Purple Book, DailyMed SPL). NDA/ANDA drugs are FDA-approved, BLA biologics are FDA-licensed. Inclusion alone does not guarantee current market availability or imply FDA endorsement.

Medical disclaimer: This AI-generated content is provided for educational purposes only and does not constitute medical advice. Always consult a licensed healthcare professional for diagnosis or treatment decisions.