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Ninjacof
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- Active ingredients
- Chlophedianol Hydrochloride 12.5 mg/5 mL
- Pyrilamine Maleate 12.5 mg/5 mL
- Other brand names
- Dosage form
- Solution
- Route
- Oral
- Prescription status
- OTC (over the counter)
- Pregnancy
- See Pregnancy Use Section
- Lactation
- See Lactation Use Section
- Marketed in the U.S.
- Since 2014
- Label revision date
- December 29, 2025
- Drug Information (PDF)
- Prescribing information, PDF file
- Active ingredients
- Chlophedianol Hydrochloride 12.5 mg/5 mL
- Pyrilamine Maleate 12.5 mg/5 mL
- Other brand names
- Dosage form
- Solution
- Route
- Oral
- Prescription status
- OTC (over the counter)
- CSA schedule
- Not a scheduled drug
- Pregnancy
- See Pregnancy Use Section
- Lactation
- See Lactation Use Section
- Marketed in the U.S.
- Since 2014
- Label revision date
- December 29, 2025
- Manufacturer
- Centurion Labs, LLC
- Registration number
- M012
- NDC root
- 23359-032
- Drug Information (PDF)
- Prescribing information, PDF file
If you are a healthcare professional or from the pharmaceutical industry please visit this version.
If you are a consumer or patient please visit this version.
Drug Overview
Ninjacof is a medication that combines an antitussive (cough suppressant) and an antihistamine to help relieve symptoms associated with the common cold, hay fever (allergic rhinitis), and other upper respiratory allergies. It works by calming the cough control center in your body, which helps reduce coughing, as well as alleviating other symptoms such as a runny nose, sneezing, and itchy, watery eyes.
This alcohol-free, dye-free, and sugar-free liquid is flavored with cotton candy, making it more pleasant to take. Each teaspoonful contains chlophendianol HCl and pyrilamine maleate, which work together to provide temporary relief from discomfort caused by minor throat and bronchial irritation.
Uses
If you're dealing with symptoms from the common cold, hay fever (which is an allergic reaction affecting your nose), or other upper respiratory allergies, this medication can help. It temporarily relieves a variety of uncomfortable symptoms, including a cough caused by minor irritation in your throat and bronchial tubes.
You can also expect relief from a runny nose, sneezing, and itching in your nose and throat. Additionally, if you have itchy, watery eyes, this medication can help calm those symptoms as well.
Dosage and Administration
For adults and children aged 12 and older, you should take 2 teaspoonfuls (10 ml) every 6 to 8 hours. However, make sure not to exceed 6 teaspoonfuls in a 24-hour period unless your doctor advises otherwise.
If your child is between 6 and 12 years old, the recommended dose is 1 teaspoonful (5 ml) every 6 to 8 hours, with a maximum of 3 teaspoonfuls in 24 hours, unless directed by a doctor. For children under 6 years of age, it’s important to consult a doctor before giving any medication. Always follow your healthcare provider's instructions for the best results.
What to Avoid
It's important to be aware of certain situations when using this medication. You should stop using it and consult your doctor if you experience nervousness, dizziness, or sleeplessness. Additionally, if your symptoms do not improve within 7 days, or if they are accompanied by a fever, rash, or a persistent headache, it's crucial to seek medical advice. A persistent cough could indicate a more serious condition, so don't hesitate to reach out to your healthcare provider if new symptoms arise.
While there are no specific contraindications or concerns about abuse, misuse, or dependence associated with this medication, staying informed and vigilant about your health is always a good practice.
Side Effects
It's important to be aware of potential side effects when using this medication. You should not exceed the recommended dosage, and avoid using it if the safety seal is missing or broken. If you have a persistent cough, especially one related to smoking, asthma, or emphysema, or if your cough produces a lot of mucus, consult your doctor before using this product.
Additionally, speak with your doctor or pharmacist if you are taking sedatives or tranquilizers, have breathing issues like emphysema or chronic bronchitis, have glaucoma, or experience difficulty urinating due to an enlarged prostate. These conditions may affect how the medication works for you.
Warnings and Precautions
It's important to follow the recommended dosage and ensure the safety seal on the product is intact before use. Avoid this product if you are currently taking a monoamine oxidase inhibitor (MAOI), which is a type of medication for depression or certain other conditions, or if you have stopped taking it within the last two weeks. If you're unsure whether your medication contains an MAOI, please consult your doctor or pharmacist.
Before using this product, talk to your doctor if you have a chronic cough, especially if it's related to smoking, asthma, or emphysema, or if you have a cough with excessive mucus. Additionally, consult a healthcare professional if you are taking sedatives, have breathing issues, glaucoma, or difficulty urinating due to an enlarged prostate. If you experience an overdose, seek emergency medical help or contact a Poison Control Center right away.
You should stop using this product and contact your doctor if you experience nervousness, dizziness, or sleeplessness, if your symptoms do not improve within seven days, or if they are accompanied by a fever, rash, or persistent headache. A new or worsening cough may indicate a more serious condition, so it's essential to seek medical advice in such cases.
Overdose
It appears that there is no specific information available regarding overdosage for this medication. However, it's always important to be aware of the potential risks associated with taking any medication. If you suspect that you or someone else may have taken too much of a medication, look out for unusual symptoms such as extreme drowsiness, confusion, or difficulty breathing.
In the event of an overdose, it is crucial to seek immediate medical help. You can do this by calling your local emergency number or going to the nearest hospital. Always keep the medication packaging on hand, as it can provide important information to healthcare professionals. Remember, when in doubt, it's better to err on the side of caution and get help.
Pregnancy Use
If you are pregnant or breastfeeding, it’s important to consult with a healthcare professional before using this medication. They can provide guidance on whether it’s safe for you and your baby. Always prioritize your health and the health of your child by seeking expert advice.
Lactation Use
If you are pregnant or breastfeeding, it’s important to consult with a healthcare professional before using any medication. This ensures that you understand any potential risks and can make informed decisions about your health and the health of your baby. Always prioritize open communication with your doctor regarding your breastfeeding journey.
Pediatric Use
If your child is 12 years old or older, they can take 2 teaspoonfuls (10 ml) every 6 to 8 hours, but make sure they do not exceed 6 teaspoonfuls in a 24-hour period unless directed by a doctor. For children aged 6 to under 12 years, the dosage is 1 teaspoonful (5 ml) every 6 to 8 hours, with a maximum of 3 teaspoonfuls in 24 hours, or as advised by a healthcare professional. If your child is under 6 years old, it’s important to consult a doctor before giving this medication.
While using this product, be aware that it may cause excitability in some children, and marked drowsiness can also occur. Always keep the medication out of reach of children, and in case of an overdose, seek medical help or contact a Poison Control Center immediately.
Geriatric Use
While there is no specific information available about the use of this medication in older adults, it’s important to approach any new treatment with caution. If you or a loved one is an older adult, it’s wise to discuss any potential risks or benefits with your healthcare provider. They can help determine the best approach based on individual health needs and any other medications being taken.
Always keep in mind that older adults may have different responses to medications, so regular check-ins with your doctor can ensure safety and effectiveness.
Renal Impairment
If you have kidney problems, it's important to know that there are no specific guidelines or dosage adjustments mentioned for your condition. This means that the information available does not provide special monitoring or safety considerations tailored for patients with renal impairment (kidney issues).
Always consult your healthcare provider for personalized advice and to ensure that any medications you take are safe and appropriate for your kidney health. They can help you understand how your condition may affect your treatment.
Hepatic Impairment
If you have liver problems, it's important to know that there are no specific guidelines or dosage adjustments mentioned for your condition in the available information. This means that the standard recommendations for the medication do not change based on liver impairment. However, it’s always a good idea to discuss your liver health with your healthcare provider, as they can offer personalized advice and monitor your condition effectively.
Make sure to keep them informed about any liver issues you may have, as they can help ensure that your treatment is safe and appropriate for you.
Drug Interactions
It's important to have open conversations with your healthcare provider about any medications or tests you may be taking. While there are no specific drug interactions or laboratory test interactions noted for this medication, your healthcare provider can help ensure that everything you are taking works well together and is safe for you. Always share your complete list of medications and any recent lab tests to avoid any potential issues. Your health and safety should always come first.
Storage and Handling
To ensure the best quality and safety of your product, store it at a temperature between 20° and 25°C (68° and 77°F). It’s acceptable for the temperature to occasionally range from 15° to 30°C (59° to 86°F). Always keep the product out of reach of children to prevent accidental ingestion or misuse. Once you open the product, be sure to discard it, as it should not be reused. Following these guidelines will help you use the product safely and effectively.
Additional Information
You should take this medication orally. If you are pregnant or breastfeeding, it's important to consult with a healthcare professional before using it. Additionally, avoid alcoholic drinks, as combining alcohol with this medication can increase drowsiness. Be cautious when driving or operating machinery, as the medication may affect your alertness.
FAQ
What is Ninjacof used for?
Ninjacof is an antitussive and antihistamine that temporarily relieves symptoms due to the common cold, hay fever, or other upper respiratory allergies, including cough, runny nose, sneezing, and itchy eyes.
What are the active ingredients in Ninjacof?
Each teaspoonful (5 mL) of Ninjacof contains 12.5 mg of Chlophendianol HCl and 12.5 mg of Pyrilamine Maleate.
What is the recommended dosage for adults and children over 12?
Adults and children 12 years and over should take 2 teaspoonfuls (10 mL) every 6 to 8 hours, not exceeding 6 teaspoonfuls in 24 hours.
What is the recommended dosage for children aged 6 to under 12?
Children aged 6 to under 12 should take 1 teaspoonful (5 mL) every 6 to 8 hours, not exceeding 3 teaspoonfuls in 24 hours.
What should I do if I experience nervousness or dizziness while taking Ninjacof?
If you experience nervousness, dizziness, or sleeplessness, stop using Ninjacof and consult a doctor.
Is Ninjacof safe to use during pregnancy or breastfeeding?
If you are pregnant or breastfeeding, ask a health professional before using Ninjacof.
What should I do in case of an overdose?
In case of overdose, seek medical help or contact a Poison Control Center immediately.
Are there any contraindications for using Ninjacof?
There are no specific contraindications listed for Ninjacof.
What precautions should I take while using Ninjacof?
Avoid alcoholic drinks, as alcohol may increase drowsiness. Be cautious when driving or operating machinery.
How should Ninjacof be stored?
Store Ninjacof at 20° - 25°C (68° - 77°F) and keep it out of reach of children.
Packaging Info
Below are the non-prescription pack sizes of Ninjacof (chlophedianol hcl and pyrilamine maleate). Columns show Packaging, Formulation Type, and Active Ingredient Strength.
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Product details Regulatory status — Marketed All current FDA data sets list this NDC as actively marketed. FDA record dates for this NDC:
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Inactive ingredients
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Product details Regulatory status — Marketed All current FDA data sets list this NDC as actively marketed. FDA record dates for this NDC:
Active ingredients
Inactive ingredients
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| Solution |
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Product details Regulatory status — Marketed All current FDA data sets list this NDC as actively marketed. FDA record dates for this NDC:
Active ingredients
Inactive ingredients
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Drug Information (PDF)
This file contains official product information for Ninjacof, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.
Description
Each teaspoonful (5 mL) contains 12.5 mg of Chlophendianol HCl and 12.5 mg of Pyrilamine Maleate. The formulation is alcohol-free, dye-free, and sugar-free, with a cotton candy flavor. The total volume of the product is 16 fl oz (473 mL).
Uses and Indications
This drug is indicated for the temporary relief of symptoms associated with the common cold, hay fever (allergic rhinitis), or other upper respiratory allergies. Specifically, it alleviates the following symptoms:
Cough due to minor throat and bronchial irritation
Coughing by calming the cough control center
Runny nose
Sneezing
Itching of the nose and throat
Itchy, watery eyes
There are no teratogenic or nonteratogenic effects associated with this drug.
Dosage and Administration
For adults and children aged 12 years and older, the recommended dosage is 2 teaspoonfuls (10 ml) every 6 to 8 hours, with a maximum of 6 teaspoonfuls in a 24-hour period, unless otherwise directed by a physician.
For children aged 6 to under 12 years, the dosage is 1 teaspoonful (5 ml) every 6 to 8 hours, not to exceed 3 teaspoonfuls in a 24-hour period, or as directed by a healthcare provider.
For children under 6 years of age, it is advised to consult a physician for appropriate dosing recommendations.
Administration should be performed using the provided measuring device to ensure accurate dosing.
Contraindications
There are no specific contraindications listed for this product. However, it is advised to discontinue use and consult a healthcare professional if any of the following occur: nervousness, dizziness, or sleeplessness; symptoms do not improve within 7 days or are accompanied by fever, rash, or persistent headache; or if new symptoms arise. These conditions may indicate a need for further evaluation or alternative treatment.
Warnings and Precautions
Healthcare professionals should be aware of the following warnings and precautions associated with the use of this product to ensure patient safety and effective treatment.
Warnings
It is imperative that the recommended dosage is not exceeded. The product must not be used if the printed safety seal is missing or broken, as this may indicate tampering or contamination. Caution is advised for patients currently taking prescription monoamine oxidase inhibitors (MAOIs), which are used for the treatment of depression, psychiatric conditions, or Parkinson's disease. The product should not be taken while on MAOIs or for at least two weeks after discontinuation. If there is uncertainty regarding the presence of an MAOI in a prescription medication, patients should consult a healthcare provider or pharmacist prior to use.
Precautions
Patients should be advised to consult a doctor before using this product if they have a cough that is chronic or persistent, particularly if it is associated with smoking, asthma, or emphysema. Additionally, those experiencing a cough with excessive phlegm (mucus) should seek medical advice.
It is also recommended that patients consult a doctor or pharmacist before use if they are currently taking sedatives or tranquilizers, have a history of breathing problems such as emphysema or chronic bronchitis, have glaucoma, or experience difficulty urinating due to prostate gland enlargement.
Emergency Situations
In the event of an overdose, immediate medical assistance should be sought, or contact with a Poison Control Center is advised.
Discontinuation of Use
Patients should discontinue use and consult a healthcare professional if they experience nervousness, dizziness, or sleeplessness. Additionally, if symptoms do not improve within seven days or are accompanied by fever, rash, or persistent headache, medical advice should be sought. A persistent cough may indicate a serious underlying condition, and new symptoms warrant immediate medical evaluation.
Side Effects
Patients should be aware of the potential adverse reactions associated with the use of this medication. It is crucial not to exceed the recommended dosage, as doing so may lead to serious complications. Additionally, the product should not be used if the printed safety seal is missing or broken, as this may indicate compromised integrity.
Before using this medication, patients are advised to consult a healthcare professional if they have a cough that is chronic, such as that associated with smoking, asthma, or emphysema, or if they experience a cough accompanied by excessive phlegm (mucus).
Furthermore, individuals should seek guidance from a doctor or pharmacist if they are currently taking sedatives or tranquilizers, have a breathing problem such as emphysema or chronic bronchitis, have glaucoma, or experience difficulty in urination due to an enlarged prostate gland. These considerations are important to ensure the safe and effective use of the medication.
Drug Interactions
There are currently no documented drug interactions associated with the use of this medication. Additionally, there is no information available regarding interactions with laboratory tests. As such, no specific recommendations for dosage adjustments or monitoring are warranted at this time.
Packaging & NDC
Below are the non-prescription pack sizes of Ninjacof (chlophedianol hcl and pyrilamine maleate). Columns show Packaging, Formulation Type, and Active Ingredient Strength.
Details | ||||
|---|---|---|---|---|
| Solution |
| ||
Product details Regulatory status — Marketed All current FDA data sets list this NDC as actively marketed. FDA record dates for this NDC:
Active ingredients
Inactive ingredients
| ||||
| Solution |
| ||
Product details Regulatory status — Marketed All current FDA data sets list this NDC as actively marketed. FDA record dates for this NDC:
Active ingredients
Inactive ingredients
| ||||
| Solution |
| ||
Product details Regulatory status — Marketed All current FDA data sets list this NDC as actively marketed. FDA record dates for this NDC:
Active ingredients
Inactive ingredients
| ||||
Pediatric Use
Pediatric patients aged 12 years and older may be administered 2 teaspoonfuls (10 ml) every 6 to 8 hours, with a maximum of 6 teaspoonfuls in a 24-hour period, or as directed by a healthcare professional. For children aged 6 to under 12 years, the recommended dosage is 1 teaspoonful (5 ml) every 6 to 8 hours, not to exceed 3 teaspoonfuls in 24 hours, or as directed by a healthcare professional.
For children under 6 years of age, consultation with a healthcare professional is advised prior to use.
When using this product, healthcare professionals should be aware that excitability may occur, particularly in pediatric patients, and marked drowsiness may also be observed. It is essential to keep this product out of reach of children. In the event of an overdose, immediate medical assistance or contact with a Poison Control Center is necessary.
Geriatric Use
There is no specific information available regarding the use of this medication in geriatric patients, including dosage adjustments, safety concerns, or special precautions. Healthcare providers should exercise caution when prescribing this medication to elderly patients, as individual responses may vary. It is advisable to monitor these patients closely for any adverse effects or changes in efficacy.
Pregnancy
Pregnant patients and those who are breastfeeding should consult a healthcare professional prior to using this medication. It is important to assess the potential risks and benefits, as well as any available data regarding fetal outcomes and maternal health. Healthcare providers should consider the individual circumstances of each patient when making recommendations.
Lactation
Lactating mothers are advised to consult a health professional prior to using this medication. There is currently no available data regarding the excretion of this medication in human breast milk or its effects on breastfed infants. Therefore, caution is recommended when administering this medication to lactating individuals.
Renal Impairment
Patients with renal impairment have not been specifically addressed in the available data regarding dosage adjustments, special monitoring, or safety considerations. Therefore, healthcare professionals should exercise caution when prescribing this medication to patients with reduced kidney function, as the lack of information necessitates careful clinical judgment and monitoring.
Hepatic Impairment
Patients with hepatic impairment have not been specifically studied in relation to the use of this medication. Consequently, there are no established dosage adjustments, special monitoring requirements, or precautions outlined for individuals with compromised liver function. It is recommended that healthcare providers exercise caution when prescribing this medication to patients with hepatic impairment, given the lack of data on its safety and efficacy in this population. Regular monitoring of liver function may be prudent in these cases, although specific parameters are not defined in the available information.
Overdosage
There is currently no specific information available regarding overdosage for this medication. Healthcare professionals are advised to monitor patients closely for any signs of adverse effects or symptoms that may arise from excessive dosing.
In the event of suspected overdosage, it is recommended that healthcare providers initiate supportive care and symptomatic treatment as necessary. Patients should be evaluated for potential complications, and appropriate interventions should be implemented based on the clinical presentation.
For further guidance, healthcare professionals should refer to established protocols and consult relevant toxicology resources.
Nonclinical Toxicology
The use of this product during pregnancy or lactation should be approached with caution. It is advisable for individuals who are pregnant or breastfeeding to consult a health professional prior to use. No specific non-teratogenic effects have been identified in the available data. Additionally, there are no specified findings related to nonclinical toxicology or animal pharmacology and toxicology.
Postmarketing Experience
Serious adverse events have been reported voluntarily or through surveillance programs. For inquiries regarding serious adverse events or to obtain additional product information, individuals are encouraged to contact 1-866-959-4880.
Patient Counseling
Healthcare providers should advise patients to keep this product out of reach of children to prevent accidental ingestion. In the event of an overdose, patients should be instructed to seek medical help or contact a Poison Control Center immediately.
Patients should be informed to stop using the product and consult a doctor if they experience nervousness, dizziness, or sleeplessness. Additionally, if symptoms do not improve within 7 days or are accompanied by a fever, rash, or persistent headache, they should seek medical advice, as a persistent cough may indicate a serious condition. Patients should also be made aware that the emergence of new symptoms warrants a consultation with a healthcare professional.
While using this product, patients should be cautioned that excitability may occur, particularly in children. Marked drowsiness is a potential side effect, and patients should be advised to avoid alcoholic beverages, as alcohol, sedatives, and tranquilizers may enhance the drowsiness effect. Furthermore, patients should exercise caution when driving a motor vehicle or operating machinery due to the risk of drowsiness.
Storage and Handling
The product is supplied in accordance with the following specifications: it should be stored at a temperature range of 20° to 25°C (68° to 77°F), with permissible excursions between 15° and 30°C (59° to 86°F) as defined by USP Controlled Room Temperature guidelines.
It is essential to keep the product out of reach of children to ensure safety. Additionally, once opened, the product must be discarded to maintain integrity and safety.
Additional Clinical Information
The medication is administered orally. Clinicians should advise patients to consult a health professional prior to use if they are pregnant or breastfeeding. Patients are also cautioned to avoid alcoholic beverages, as the combination of alcohol, sedatives, and tranquilizers may enhance drowsiness. Additionally, patients should exercise caution when driving or operating machinery due to potential drowsiness effects.
Drug Information (PDF)
This file contains official product information for Ninjacof, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.