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Nitrogen

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Active ingredient
Nitrogen 99 L/100 L
Other brand names
Dosage form
Liquid
Route
Respiratory (inhalation)
Prescription status
Rx (prescription)
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 1938
Label revision date
October 31, 2018
FDA Insert
Prescribing information, PDF file
Active ingredient
Nitrogen 99 L/100 L
Other brand names
Dosage form
Liquid
Route
Respiratory (inhalation)
Prescription status
Rx (prescription)
CSA schedule
Not a scheduled drug
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 1938
Label revision date
October 31, 2018
Manufacturer
PURITY CYLINDER GASES INC
Registration number
NDA205766
NDC root
10927-106
FDA Insert
Prescribing information, PDF file
Packaging Info (8 NDCs)
Packaging & NDC Codes (8)

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Drug Overview

Nitrogen Refrigerated Liquid NF is a specialized gas used primarily in various industrial applications. It is classified as UN 1977 and is known for its ability to maintain extremely low temperatures. This makes it useful in processes that require rapid cooling or freezing.

However, it's important to note that the administration of nitrogen should only be performed by a licensed practitioner who is experienced in its use. Due to its properties, nitrogen can cause cryogenic burns and may displace oxygen in the air, leading to suffocation risks. Therefore, safety precautions are essential when handling this substance.

Uses

You should know that the administration of Nitrogen can be risky and is not suitable for everyone. It is important that this treatment is only given by a licensed healthcare professional who has experience with Nitrogen. They will understand how to use it safely, including the correct dosages, methods, and duration of treatment, as well as any potential hazards or side effects.

Additionally, there are no reported teratogenic effects (which means it does not cause birth defects) or nonteratogenic effects associated with Nitrogen. However, always consult with your healthcare provider for personalized advice and information regarding your specific situation.

Dosage and Administration

When using this medication, you will be inhaling nitrogen, which is a gas that makes up a large part of the air we breathe. It is important to note that this treatment should only be administered by a licensed practitioner who is experienced in its use, as it can be hazardous if not handled properly.

You should always use and store the nitrogen outdoors or in a well-ventilated area to ensure safety. Additionally, make sure to keep the container in an upright position at all times to prevent any accidents. Following these guidelines will help ensure that you use the medication safely and effectively.

What to Avoid

Using Nitrogen can be risky, so it's crucial that you only use it under the guidance of a licensed practitioner who is experienced in its administration. Before handling Nitrogen, make sure you have read and understood all safety precautions. Always use and store Nitrogen outdoors or in a well-ventilated area to minimize hazards.

When working with Nitrogen, protect yourself by wearing cold insulating gloves, a face shield, and eye protection. Never attempt to change or force fit connections, and remember to close the valve after each use and when the container is empty. Always keep containers in an upright position to ensure safety.

Side Effects

Using nitrogen refrigerated liquid can lead to serious side effects. It may cause cryogenic burns or injuries, which occur when skin comes into contact with extremely cold substances. Additionally, nitrogen can displace oxygen in the air, potentially leading to rapid suffocation.

If you inhale nitrogen, it's important to move to fresh air and stay comfortable while breathing. If it comes into contact with your skin, gently thaw the affected area with lukewarm water—do not rub it—and seek immediate medical attention. Always ensure that nitrogen is administered by a licensed practitioner who is knowledgeable about its use and potential risks.

Warnings and Precautions

Using Nitrogen can be risky and should only be done by a trained professional who understands how to handle it safely. This gas is stored under refrigeration and can cause serious injuries, such as cryogenic burns (frostbite from extremely cold substances) or suffocation by displacing oxygen. Always read the safety precautions before handling Nitrogen, and ensure you use it outdoors or in a well-ventilated area. Wear protective gear, including cold insulating gloves and eye protection, and keep the containers upright.

If someone inhales Nitrogen, move them to fresh air and help them breathe comfortably. If Nitrogen comes into contact with skin, gently thaw the affected area with lukewarm water—do not rub it—and seek medical attention right away. Always close the valve after use and store the containers properly to prevent accidents.

Overdose

Using Nitrogen can be risky and should only be done by a trained professional who understands how to use it safely. This is important because improper use can lead to serious health issues.

If you or someone else accidentally inhales Nitrogen, it’s crucial to move to fresh air right away and stay comfortable while breathing. If Nitrogen comes into contact with the skin, do not rub the area; instead, gently thaw any frost with lukewarm water and seek medical advice immediately. Be aware that Nitrogen can cause cryogenic burns (injuries from extreme cold) and may displace oxygen, leading to rapid suffocation. If you notice any signs of distress, such as difficulty breathing or skin injuries, seek help right away.

Pregnancy Use

Using Nitrogen during pregnancy may pose risks, and its administration should only be done by a licensed practitioner who is experienced in its use. Currently, there is no specific information available about the safety of Nitrogen for pregnant individuals, including any necessary dosage adjustments or special precautions.

If you are pregnant or planning to become pregnant, it is essential to discuss any potential use of Nitrogen with your healthcare provider to ensure your safety and the safety of your baby.

Lactation Use

If you are breastfeeding or planning to breastfeed, it's important to note that there is no specific information available about the use of Nitrogen in nursing mothers or its effects on lactation (the production of breast milk). This means that the potential impact on your milk supply or your baby's health is not clearly defined.

As always, it's best to consult with your healthcare provider for personalized advice regarding any medications you may be considering while breastfeeding. They can help you weigh the benefits and risks based on your individual situation.

Pediatric Use

Using Nitrogen in children should be approached with caution. It is important that this substance is administered only by a licensed healthcare professional who has experience with Nitrogen. This ensures that they are familiar with its effects, proper dosages, and any potential risks involved.

You should be aware that Nitrogen can be hazardous; it may cause cryogenic burns (injuries from extreme cold) and can displace oxygen, leading to suffocation. Always read and understand the safety precautions before handling Nitrogen. It should only be used outdoors or in well-ventilated areas, and protective gear like cold insulating gloves and eye protection is essential. Make sure to follow all safety guidelines, including keeping containers upright and closing valves after use.

Geriatric Use

When it comes to using this medication in older adults, there is no specific information available about dosage adjustments, safety concerns, or special precautions. This means that if you or a loved one is an older adult considering this medication, it’s important to consult with a healthcare provider. They can help determine the best approach based on individual health needs and any other medications being taken. Always prioritize open communication with your healthcare team to ensure safe and effective treatment.

Renal Impairment

If you have kidney problems, it's important to know that the information provided does not include specific guidelines for dosage adjustments, special monitoring, or safety considerations related to renal impairment (kidney issues). This means that there are no tailored recommendations for how your treatment may need to be adjusted based on your kidney function.

Always consult your healthcare provider for personalized advice and to ensure that your treatment plan is safe and effective for your specific situation. They can help monitor your kidney health and make any necessary changes to your medications.

Hepatic Impairment

If you have liver problems, it's important to know that the drug insert for Nitrogen does not provide specific information about dosage adjustments, special monitoring, or precautions for your condition. This means that there are no established guidelines for how this medication should be used in patients with liver impairment.

Before starting any new medication, including Nitrogen, you should discuss your liver health with your healthcare provider. They can help determine the best approach for your treatment and ensure your safety.

Drug Interactions

It's important to have open conversations with your healthcare provider about any medications or tests you may be taking. While there are no specific drug interactions or laboratory test interactions noted for this medication, your healthcare provider can help ensure that everything you are taking works well together and is safe for you. Always share your complete list of medications and any lab tests you undergo, as this helps in managing your health effectively.

Storage and Handling

To ensure your safety and the proper use of the product, always keep the container in an upright position. It’s important to use and store the product outdoors or in a well-ventilated area to avoid any harmful buildup of gases. When handling the container, make sure to wear cold insulating gloves, a face shield, and eye protection to protect yourself from potential hazards.

Before you begin, take the time to read and understand all safety precautions. After each use, remember to close the valve, especially when the container is empty, to prevent any accidental leaks or exposure. Following these guidelines will help you use the product safely and effectively.

Additional Information

When using Nitrogen, it's important to remember that it should only be administered by a licensed practitioner who is experienced in its use. This means you should not attempt to use it on your own. Make sure to read and understand all safety precautions before handling Nitrogen. Always use it outdoors or in a well-ventilated area, and wear protective gear such as cold insulating gloves, a face shield, and eye protection.

Additionally, ensure that you use a backflow preventive device in the piping, avoid changing or forcing connections, and close the valve after each use. Always keep containers upright and refer to the Safety Data Sheet (SDS) for detailed safety information before use.

FAQ

What is Nitrogen Refrigerated Liquid NF?

Nitrogen Refrigerated Liquid NF is a refrigerated gas classified as UN 1977, used under strict supervision by licensed practitioners.

What are the safety precautions for handling Nitrogen?

You must read and understand all safety precautions before handling Nitrogen. Always use it outdoors or in a well-ventilated area, wear cold insulating gloves, a face shield, and eye protection.

What should I do if Nitrogen is inhaled?

If inhaled, remove the person to fresh air and keep them comfortable for breathing.

What should I do if Nitrogen comes into contact with skin?

Thaw frosted parts with lukewarm water without rubbing the affected area, and seek immediate medical advice.

What are the potential hazards of using Nitrogen?

Nitrogen may cause cryogenic burns or injury and can displace oxygen, leading to rapid suffocation.

How should Nitrogen be stored?

Always keep Nitrogen containers in an upright position and store them outdoors or in a well-ventilated place.

Who should administer Nitrogen?

Nitrogen should only be administered by or under the supervision of a licensed practitioner experienced in its use.

Is there any information on the use of Nitrogen during pregnancy?

No specific information regarding the use of Nitrogen during pregnancy is provided.

Are there any known side effects of Nitrogen?

The main side effects include cryogenic burns and the risk of oxygen displacement, which can cause suffocation.

What is the active ingredient in Nitrogen Refrigerated Liquid NF?

The active ingredient in Nitrogen Refrigerated Liquid NF is Nitrogen, with a strength of 99 L in 100 L.

Packaging Info

The table below lists all NDC Code configurations of Nitrogen, the U.S. brand-name prescription product. Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Nitrogen.
Details

FDA Insert (PDF)

This is the full prescribing document for Nitrogen, submitted to the U.S. Food and Drug Administration (FDA). It contains official information for healthcare providers, including how to use the medication, possible side effects, and safety warnings.

View FDA-approved insert (PDF)

Description

Nitrogen Refrigerated Liquid NF is a cryogenic liquid with the chemical formula N₂. It is classified under UN 1977 and has a CAS number of 77227-37-9. This substance is utilized primarily in various industrial and scientific applications due to its properties as a refrigerant. As a liquid nitrogen, it exists at extremely low temperatures, making it essential for processes requiring rapid cooling or preservation.

Uses and Indications

This drug is indicated for use in specific medical situations where the administration of Nitrogen is deemed necessary. It is essential that this drug be administered only by or under the supervision of a licensed practitioner who possesses experience in the use and administration of Nitrogen. The practitioner must be knowledgeable about the indications, effects, dosages, methods, frequency, and duration of administration, as well as the associated hazards, contraindications, side effects, and necessary precautions.

Limitations of use include the potential hazards associated with Nitrogen administration, which may render it contraindicated in certain circumstances. There are no reported teratogenic or nonteratogenic effects associated with this drug.

Dosage and Administration

Administration of Nitrogen is intended for respiratory inhalation only. The active ingredient is nitrogen at a strength of 99 L in 100 L. Due to the potential hazards associated with nitrogen, its use is contraindicated unless administered by or under the supervision of a licensed practitioner experienced in its application.

It is imperative that nitrogen is utilized and stored exclusively outdoors or in a well-ventilated area to ensure safety. The container must always be maintained in an upright position to prevent any risk of leakage or accidents during handling.

Contraindications

Administration of Nitrogen is contraindicated in situations where safety precautions have not been fully understood or implemented. The use of Nitrogen should be restricted to licensed practitioners experienced in its administration.

Handling of Nitrogen is prohibited until all safety precautions have been thoroughly reviewed. It is essential to use and store Nitrogen exclusively outdoors or in well-ventilated areas to mitigate risks associated with its use.

Personal protective equipment, including cold insulating gloves, face shields, and eye protection, must be worn during handling. Additionally, connections should not be changed or forced, and the valve must be closed after each use and when the container is empty. Containers should always be maintained in an upright position to ensure safety.

Warnings and Precautions

Administration of Nitrogen may pose significant hazards and is contraindicated in certain situations. It is imperative that this substance is used solely by or under the supervision of a licensed practitioner who possesses expertise in the use and administration of Nitrogen. This includes familiarity with its indications, effects, dosages, methods, frequency and duration of administration, as well as an understanding of the associated hazards, contraindications, side effects, and necessary precautions.

The product contains refrigerated gas, which can lead to cryogenic burns or injuries. Additionally, it has the potential to displace oxygen, resulting in rapid suffocation. Therefore, it is crucial that all safety precautions are thoroughly read and understood prior to handling. Nitrogen should only be used and stored outdoors or in a well-ventilated area. Appropriate personal protective equipment, including cold insulating gloves, a face shield, and eye protection, must be worn during handling. A backflow preventive device should be utilized in the piping system. It is essential to avoid changing or forcing connections and to close the valve after each use and when the container is empty. Containers should always be maintained in an upright position.

Healthcare professionals are advised to read and follow the Safety Data Sheet (SDS) before use to ensure comprehensive understanding of the safety measures associated with Nitrogen.

In the event of an emergency, specific actions should be taken. If Nitrogen is inhaled, the individual should be removed to fresh air and kept comfortable for breathing. If the gas comes into contact with the skin, any frosted areas should be thawed using lukewarm water, and the affected area should not be rubbed. Immediate medical advice or attention should be sought in both scenarios.

No specific laboratory tests are recommended for monitoring the use of Nitrogen.

Side Effects

The administration of Nitrogen Refrigerated Liquid NF may lead to serious adverse reactions, including cryogenic burns or injury, which can occur upon direct contact with the skin. Additionally, there is a risk of oxygen displacement, which may result in rapid suffocation.

In the event of inhalation, it is crucial to remove the affected individual to fresh air and ensure they are comfortable for breathing. If the substance comes into contact with the skin, it is recommended to thaw any frosted areas with lukewarm water without rubbing the affected skin. Immediate medical advice and attention should be sought in such cases.

Due to the potential hazards associated with Nitrogen, its administration may be contraindicated in certain situations. It is intended for use only by or under the supervision of a licensed practitioner who possesses experience in the use and administration of Nitrogen. This practitioner should be well-versed in the indications, effects, dosages, methods, frequency, duration of administration, as well as the associated hazards, contraindications, side effects, and necessary precautions.

Drug Interactions

There are currently no specific drug interactions identified for the medication. Additionally, no interactions with laboratory tests have been reported. Therefore, no dosage adjustments or monitoring recommendations are necessary at this time.

Packaging & NDC

The table below lists all NDC Code configurations of Nitrogen, the U.S. brand-name prescription product. Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Nitrogen.
Details

Pediatric Use

Administration of Nitrogen in pediatric patients may pose significant hazards and is contraindicated unless performed by or under the supervision of a licensed practitioner experienced in its use. This practitioner must be knowledgeable about the indications, effects, dosages, methods, frequency, duration of administration, as well as the associated hazards, contraindications, side effects, and necessary precautions.

Due to the nature of Nitrogen as a refrigerated gas, there is a risk of cryogenic burns or injury. Additionally, Nitrogen may displace oxygen, leading to rapid suffocation. Therefore, it is critical that all safety precautions are thoroughly read and understood prior to handling. Nitrogen should only be used and stored outdoors or in well-ventilated areas. Appropriate personal protective equipment, including cold insulating gloves, face shields, and eye protection, must be worn during administration.

It is imperative to utilize a backflow preventive device in the piping and to avoid altering or forcing connections. The valve should be closed after each use and when the container is empty, and containers must always be kept in an upright position. Prior to use, the Safety Data Sheet (SDS) must be read and followed to ensure safe handling and administration practices.

Geriatric Use

Elderly patients may not have specific information regarding the use of this medication, including dosage adjustments, safety concerns, or special precautions. Therefore, healthcare providers should exercise caution when prescribing this medication to geriatric patients. It is advisable to monitor these patients closely for any adverse effects or changes in therapeutic response, given the lack of targeted data for this population.

Pregnancy

The administration of Nitrogen during pregnancy may pose potential risks, and its use is contraindicated or hazardous. There is no specific information available regarding the safety of Nitrogen in pregnant patients, including any associated fetal impacts or necessary dosage modifications. Therefore, it is crucial that Nitrogen is used only by or under the supervision of a licensed practitioner who has experience in its administration. Healthcare professionals should exercise caution and consider the lack of data when evaluating the use of Nitrogen in women of childbearing potential.

Lactation

There is no specific information regarding the use of Nitrogen in nursing mothers or lactation considerations provided in the drug insert. Therefore, healthcare professionals should exercise caution when prescribing this medication to lactating mothers, as the effects on breastfed infants are not established. It is advisable to weigh the potential benefits against any unknown risks when considering the use of this drug in breastfeeding patients.

Renal Impairment

Patients with renal impairment have not been specifically addressed in the prescribing information regarding dosage adjustments, special monitoring, or safety considerations. Therefore, healthcare professionals should exercise caution when prescribing this medication to patients with reduced kidney function, as the absence of detailed guidance necessitates careful clinical judgment and monitoring of these patients.

Hepatic Impairment

Patients with hepatic impairment have not been specifically studied in relation to the use of Nitrogen. Consequently, there is no available information regarding dosage adjustments, special monitoring requirements, or precautions for this population. It is recommended that healthcare providers exercise caution when prescribing Nitrogen to patients with compromised liver function, given the lack of data on its safety and efficacy in this group. Regular monitoring of liver function may be prudent in these cases, although specific parameters are not outlined in the prescribing information.

Overdosage

Administration of Nitrogen may pose significant risks and is contraindicated in certain situations. It is imperative that Nitrogen is used solely by or under the supervision of a licensed practitioner who possesses expertise in its use and administration. This includes a thorough understanding of the indications, effects, dosages, methods, frequency, duration of administration, as well as the associated hazards, contraindications, side effects, and necessary precautions.

Warnings and Risks Nitrogen is classified as a refrigerated gas, which presents specific hazards. It may cause cryogenic burns or injuries upon contact with skin. Additionally, Nitrogen can displace oxygen in the environment, leading to rapid suffocation.

Management of Overdosage In the event of inhalation, it is crucial to remove the affected individual to an area with fresh air and ensure they are comfortable while breathing. Should there be contact with the skin, it is essential to thaw any frosted areas using lukewarm water; rubbing the affected area is strictly prohibited. Immediate medical advice and attention should be sought to address any potential injuries or complications arising from overdosage.

Nonclinical Toxicology

No teratogenic or non-teratogenic effects have been reported in the available nonclinical studies. Additionally, there is no information regarding animal pharmacology and toxicology. The absence of data in these areas limits the understanding of the compound's potential effects in nonclinical settings.

Postmarketing Experience

No postmarketing experience details are available in the provided text.

Patient Counseling

Healthcare providers should advise patients to always keep the container in an upright position to ensure safe handling and storage. It is crucial to inform patients that the administration of Nitrogen may be hazardous or contraindicated and should only be performed by or under the supervision of a licensed practitioner who is experienced in its use. This practitioner should be familiar with the indications, effects, dosages, methods, frequency, duration of administration, as well as the associated hazards, contraindications, side effects, and necessary precautions.

Providers must emphasize the warning that the product contains refrigerated gas, which may cause cryogenic burns or injury. Additionally, it may displace oxygen and lead to rapid suffocation. Patients should be instructed not to handle the container until all safety precautions have been read and understood.

It is important to counsel patients to use and store the product only outdoors or in a well-ventilated area. They should wear appropriate protective gear, including cold insulating gloves, a face shield, and eye protection, to minimize the risk of injury. Providers should also recommend the use of a backflow preventive device in the piping to ensure safety during administration.

Patients must be cautioned against changing or forcing connections, as this could lead to dangerous situations. They should be reminded to close the valve after each use and when the container is empty. Furthermore, healthcare providers should stress the importance of reading and following the Safety Data Sheet (SDS) before use.

In the event of inhalation, patients should be instructed to remove the affected person to fresh air and keep them comfortable for breathing. If Nitrogen comes into contact with the skin, patients should thaw any frosted areas with lukewarm water without rubbing the affected area and seek immediate medical advice or attention.

Storage and Handling

The product is supplied in containers that must always be kept in an upright position. It is essential to use and store the product exclusively outdoors or in a well-ventilated area to ensure safety.

When handling the product, personnel are required to wear appropriate protective equipment, including cold insulating gloves, a face shield, and eye protection. It is crucial to close the valve after each use and when the container is empty to prevent any accidental release.

Before handling the product, all safety precautions must be thoroughly read and understood to ensure safe usage and compliance with handling guidelines.

Additional Clinical Information

The route of administration for Nitrogen is via respiratory inhalation. It is crucial that this substance is administered only by or under the supervision of a licensed practitioner who is knowledgeable about its indications, effects, dosages, methods, frequency, duration, hazards, contraindications, side effects, and necessary precautions.

Clinicians should counsel patients on the potential hazards associated with Nitrogen. It is essential to read and understand all safety precautions before handling. Nitrogen should be used and stored outdoors or in well-ventilated areas, with appropriate personal protective equipment such as cold insulating gloves, face shields, and eye protection. A backflow preventive device should be utilized in the piping, and connections must not be altered or forced. Valves should be closed after each use and when empty, and containers must always be kept in an upright position. Patients are advised to read and follow the Safety Data Sheet (SDS) prior to use.

FDA Insert (PDF)

This document is the official FDA-approved prescribing information for Nitrogen as submitted by PURITY CYLINDER GASES INC. It includes detailed information about indications, dosage, contraindications, warnings, and clinical pharmacology.

View full prescribing information (PDF)

Data Generation & Sources

This page was automatically generated and is maintained by the AllDrugs AI Data-Science Team. It was built from the FDA Structured Product Label (DailyMed) for Nitrogen, retrieved by a validated AI data-extraction workflow.

All FDA-approved dosage forms and strengths are listed in the Packaging & NDC Codes section above. Regulatory status, pharmacologic class (EPC), and mechanism of action (MoA) were cross-checked against the FDA Orange Book (NDA205766) and the NSDE NDC Directory daily file.

Note: an automated daemon monitors NSDE checksums; when the record for this NDC changes, the new file is pulled instantly and this page is refreshed.

No human clinician has reviewed this version.

Learn more in our Editorial Policy

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Primary FDA sources:

Orange Book data shown on this page are limited to Regulatory Status (Rx), Established Pharmacologic Class (EPC), and Mechanism of Action (MoA).

Regulatory data notice: Information on this page is reproduced verbatim from FDA public databases (NSDE, Orange Book, Purple Book, DailyMed SPL). NDA/ANDA drugs are FDA-approved, BLA biologics are FDA-licensed. Inclusion alone does not guarantee current market availability or imply FDA endorsement.

Medical disclaimer: This AI-generated content is provided for educational purposes only and does not constitute medical advice. Always consult a licensed healthcare professional for diagnosis or treatment decisions.