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Nitrogen

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This product has been discontinued

Active ingredient
Nitrogen 99 L/100 L
Other brand names
Dosage form
Gas
Route
Respiratory (inhalation)
Prescription status
Rx (prescription)
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 2010
Label revision date
November 3, 2011
FDA Insert
Prescribing information, PDF file
Active ingredient
Nitrogen 99 L/100 L
Other brand names
Dosage form
Gas
Route
Respiratory (inhalation)
Prescription status
Rx (prescription)
CSA schedule
Not a scheduled drug
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 2010
Label revision date
November 3, 2011
Manufacturer
Specialty Gases of America LLC
NDC root
59754-002
FDA Insert
Prescribing information, PDF file
Packaging Info (3 NDCs)
Packaging & NDC Codes (3)

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If you are a consumer or patient please visit this version.

Drug Overview

Nitrogen Refrigerated Liquid NF is a non-flammable gas that is primarily used in various industrial and medical applications. It is important to note that the administration of nitrogen should only be performed by or under the supervision of a licensed practitioner who is experienced in its use.

This substance is known for its extremely cold properties, which can be hazardous if not handled properly. While it serves essential functions in different settings, safety precautions are crucial to prevent risks such as suffocation or frostbite.

Uses

You may be considering the use of nitrogen for certain medical purposes. It's important to know that the administration of nitrogen can be risky and should only be done by a licensed healthcare professional who has experience with this treatment. They will understand the appropriate uses, effects, dosages, and methods for administering nitrogen, as well as the potential hazards and precautions necessary to ensure safety.

While there are no specific teratogenic effects (which means effects that could harm a developing fetus) or nonteratogenic effects noted, it's crucial to consult with your healthcare provider to discuss any concerns or questions you may have regarding the use of nitrogen in your treatment plan.

Dosage and Administration

When using this medication, you will be inhaling nitrogen, which is a gas that makes up a large part of the air we breathe. It is important to note that this treatment should only be administered by a licensed healthcare professional who is experienced in using nitrogen. This is because inhaling nitrogen can be hazardous if not done correctly.

Before starting treatment, your healthcare provider will ensure that they are familiar with the specific reasons for using nitrogen, its effects, and the proper dosages and methods for administration. They will also guide you on how often and for how long you should receive this treatment to ensure your safety and effectiveness. Always follow their instructions closely to achieve the best results.

What to Avoid

It's important to be aware of certain precautions when using this product. First, the administration of nitrogen can be risky and should only be done by a licensed practitioner who has experience with it. You should never attempt to change or force fit any connections, as this can lead to dangerous situations.

Additionally, avoid getting the liquid in your eyes, on your skin, or on your clothing, as this can cause harm. Always handle the product carefully—do not drop it. After each use, and when the product is empty, make sure to close the valve to ensure safety.

Side Effects

Using nitrogen can pose serious risks, including the potential for rapid suffocation and severe frostbite due to its extremely cold temperature and pressurized state. If you experience any issues while using nitrogen, such as difficulty breathing, it's crucial to move to fresh air immediately. If you stop breathing, artificial respiration should be administered, and if you're having trouble breathing, oxygen may be necessary. Always seek medical attention if frostbite occurs or if you have any concerns about your health.

Warnings and Precautions

Using nitrogen can be risky and should only be done by a trained professional who understands how to handle it safely. This substance is extremely cold and can cause serious injuries, such as frostbite or suffocation. Always ensure you have good ventilation when using nitrogen, and avoid contact with your skin, eyes, or clothing. If you need to handle the container, use protective gear like gloves and a face shield, and make sure to follow safety guidelines closely.

If you accidentally inhale nitrogen or experience frostbite, it’s important to seek medical help right away. For inhalation, move to fresh air, and if breathing is difficult, provide oxygen or perform artificial respiration until help arrives. Always close the valve after use and store the nitrogen properly to prevent accidents.

Overdose

Using nitrogen can be risky and should only be done under the guidance of a qualified healthcare professional who understands how to use it safely. This is important because nitrogen is extremely cold and can be dangerous if not handled properly. It can cause rapid suffocation and severe frostbite if it comes into contact with your skin.

If you suspect an overdose or experience any adverse effects, such as difficulty breathing or frostbite, it’s crucial to act quickly. Move to fresh air immediately. If you or someone else is not breathing, perform artificial respiration. If breathing is difficult, provide oxygen if available. Always seek medical help right away, especially in cases of frostbite, to ensure proper treatment.

Pregnancy Use

Using nitrogen during pregnancy can pose significant risks, so it's crucial to approach this with caution. The administration of nitrogen should only be done by a licensed practitioner who has experience with its use. This is important because nitrogen can be extremely cold and is stored under pressure, which can lead to rapid suffocation or severe frostbite if not handled properly.

If you are pregnant or planning to become pregnant, it’s essential to discuss any potential exposure to nitrogen with your healthcare provider. Always ensure that any product you use is properly labeled and never remove the label, as it contains important safety information. Your safety and the safety of your baby should always come first.

Lactation Use

Currently, there is no specific information available about the use of Nitrogen for nursing mothers or its effects on breastfeeding. This means that if you are breastfeeding or planning to breastfeed, there are no established guidelines or warnings related to this medication.

If you have concerns about how any medication might affect your milk production or your baby, it's always best to consult with your healthcare provider for personalized advice. They can help you weigh the benefits and risks based on your individual situation.

Pediatric Use

When considering the use of nitrogen for your child, it's important to know that its administration can be risky and is not recommended without proper supervision. Only a licensed healthcare professional who has experience with nitrogen should administer it. This expert will be familiar with the specific reasons for use, the correct dosages, and the potential side effects, as well as the necessary precautions to ensure your child's safety.

Always consult with your child's doctor before any treatment involving nitrogen to ensure it is appropriate for their specific situation. Your child's health and safety should always come first, so make sure to follow professional guidance closely.

Geriatric Use

While there is no specific information about how this medication should be used by older adults, it’s important to approach any new treatment with caution. Since older adults may have different health needs and may be taking multiple medications, it’s always a good idea to discuss any concerns with your healthcare provider. They can help determine the best approach for you, considering factors like your overall health and any other medications you may be using.

If you or a loved one is an older adult, make sure to monitor for any unusual side effects or changes in health after starting a new medication, and don’t hesitate to reach out to your doctor with any questions or concerns.

Renal Impairment

If you have kidney problems, it's important to know that there are no specific guidelines or dosage adjustments mentioned for your condition in the available information. This means that the usual recommendations for monitoring or safety considerations related to renal impairment (kidney issues) are not provided.

Always consult your healthcare provider for personalized advice and to ensure that any medications you take are safe and appropriate for your kidney health. They can help you understand how your condition may affect your treatment plan.

Hepatic Impairment

If you have liver problems, it's important to know that the drug insert for Nitrogen does not provide specific information about dosage adjustments, special monitoring, or precautions for your condition. This means that there are no established guidelines for how this medication should be used if you have hepatic impairment (liver problems).

Before starting any new medication, including Nitrogen, you should discuss your liver health with your healthcare provider. They can help determine the best approach for your treatment and ensure your safety.

Drug Interactions

It's important to be aware that using nitrogen alongside certain medications can be risky or even not recommended. This is why discussing all your current medications with your healthcare provider is crucial. They can help you understand any potential interactions and ensure your treatment is safe and effective.

Additionally, there are no specific interactions noted between drugs and laboratory tests in the information provided. However, always keep your healthcare provider informed about any tests you may undergo, as they can guide you on how to prepare and what to expect. Open communication is key to your health and safety.

Storage and Handling

To ensure safe storage and handling of the product, always keep the container in an upright position and store it in a well-ventilated area. Avoid changing or forcing any connections, and never drop the container. When moving it, use a suitable hand truck to prevent accidents. It's important to keep the cylinder temperature below 52°C (125°F) and to close the valve after each use and when the container is empty.

When withdrawing liquid, make sure to wear a face shield and gloves to protect yourself. Be cautious to avoid getting any liquid in your eyes, on your skin, or on your clothing. Additionally, always use a backflow preventative device in the piping and follow the guidelines provided in the Material Safety Data Sheet (MSDS) for safe handling practices.

Additional Information

You will use this medication through inhalation, which means you will breathe it in to receive the treatment. There are no additional details available regarding laboratory tests, abuse potential, or patient counseling information.

FAQ

What is Nitrogen Refrigerated Liquid NF?

Nitrogen Refrigerated Liquid NF is a non-flammable gas, classified as UN1977.

Who should administer Nitrogen?

Nitrogen should only be administered by or under the supervision of a licensed practitioner experienced in its use and administration.

What are the hazards associated with Nitrogen?

Nitrogen can cause rapid suffocation and severe frostbite due to its extremely cold liquid and gas under pressure.

What precautions should I take when using Nitrogen?

Store and use Nitrogen with adequate ventilation, avoid contact with eyes, skin, or clothing, and wear a face shield and gloves during liquid withdrawal.

What should I do in case of inhalation or frostbite?

If inhaled, remove the person to fresh air and call a physician. For frostbite, obtain medical treatment immediately.

What is the route of administration for Nitrogen?

Nitrogen is administered via respiratory inhalation.

What is the strength of Nitrogen in this product?

The strength of Nitrogen in this product is 99 L in 100 L.

What should I avoid when using Nitrogen?

Do not change or force fit connections, drop the container, or allow the cylinder temperature to exceed 52°C (125°F).

Is there any information on teratogenic effects?

No specific teratogenic effects are mentioned for Nitrogen.

Are there any specific instructions for container handling?

Always keep the container in an upright position and use a suitable hand truck for movement.

Packaging Info

The table below lists all NDC Code configurations of Nitrogen, the U.S. brand-name prescription product. Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Nitrogen.
Details

FDA Insert (PDF)

This is the full prescribing document for Nitrogen, submitted to the U.S. Food and Drug Administration (FDA). It contains official information for healthcare providers, including how to use the medication, possible side effects, and safety warnings.

View FDA-approved insert (PDF)

Description

Refrigerated Liquid Nitrogen is a non-flammable gas classified under UN1977, with a CAS number of 7727-37-9. It is essential to maintain the container in an upright position and to avoid altering or forcing connections. This product is available by prescription only and should be administered solely by or under the supervision of a licensed practitioner experienced in nitrogen use.

The administration of nitrogen may pose hazards or contraindications; therefore, practitioners must be knowledgeable about its indications, effects, dosages, methods, frequency, duration of administration, as well as the associated hazards, contraindications, side effects, and necessary precautions.

This substance is extremely cold and exists under pressure, which can lead to rapid suffocation and severe frostbite. It is crucial to store and use it in well-ventilated areas, avoiding contact with eyes, skin, or clothing. When withdrawing liquid nitrogen, appropriate personal protective equipment, including a face shield and gloves, should be worn. Containers should not be dropped, and a suitable hand truck should be utilized for movement. The cylinder temperature must not exceed 52°C (125°F), and the valve should be closed after each use and when empty. A backflow preventative device should be employed in the piping, and usage must comply with the Material Safety Data Sheet (MSDS).

In case of inhalation, the individual should be moved to fresh air, and if not breathing, artificial respiration should be administered. If breathing difficulties arise, oxygen should be provided, and a physician should be contacted. Immediate medical treatment is necessary for frostbite. The product label must not be removed.

Uses and Indications

This drug is indicated for the administration of nitrogen under specific conditions. It is intended for use only by or under the supervision of a licensed practitioner who possesses experience in the use and administration of nitrogen. The practitioner must be knowledgeable about the indications, effects, dosages, methods, frequency, and duration of administration, as well as the associated hazards, contraindications, side effects, and necessary precautions.

Limitations of use include the potential hazards associated with nitrogen administration, which may be contraindicated in certain situations. There are no specific teratogenic or nonteratogenic effects reported for this drug.

Dosage and Administration

Administration of nitrogen is to be conducted exclusively via the respiratory route through inhalation. The active ingredient is nitrogen, with a strength of 99 L in 100 L.

Due to the potential hazards associated with nitrogen administration, it is imperative that this procedure is performed only by or under the supervision of a licensed practitioner who possesses experience in the use and administration of nitrogen.

Healthcare professionals must ensure they are thoroughly familiar with the indications, effects, dosages, methods, frequency, and duration of administration prior to proceeding with treatment.

Contraindications

Administration of nitrogen is contraindicated except when performed by or under the supervision of a licensed practitioner experienced in its use and administration, due to potential hazards associated with its use.

Additionally, the following precautions must be observed: connections should not be altered or forced; liquid nitrogen must not come into contact with eyes, skin, or clothing; the product should not be dropped; and the valve must be closed after each use and when empty to ensure safety and proper functioning.

Warnings and Precautions

Administration of nitrogen may pose significant hazards and is contraindicated in certain situations. It is imperative that nitrogen is used solely by or under the supervision of a licensed practitioner who possesses experience in its administration. This practitioner must be well-versed in the indications, effects, dosages, methods, frequency, duration of administration, as well as the associated hazards, contraindications, side effects, and necessary precautions.

Nitrogen is stored and utilized in extremely cold liquid and gas forms under pressure, which can lead to rapid suffocation and severe frostbite if not handled properly. Adequate ventilation is essential during storage and use. Direct contact with the liquid should be avoided; it must not come into contact with the eyes, skin, or clothing. When withdrawing liquid nitrogen, appropriate personal protective equipment, including a face shield and gloves, should be worn. Containers should not be dropped, and a suitable hand truck should be employed for movement. It is critical to ensure that the cylinder temperature does not exceed 52°C (125°F). After each use and when the cylinder is empty, the valve should be closed, and a backflow preventative device should be utilized in the piping. All handling and usage should comply with the guidelines outlined in the Material Safety Data Sheet (MSDS).

In the event of an emergency, immediate first aid measures should be taken. If nitrogen is inhaled, the individual should be removed to fresh air. If the person is not breathing, artificial respiration should be administered. If breathing is difficult, oxygen should be provided, and a physician should be contacted without delay. In cases of frostbite, it is crucial to seek medical treatment immediately.

No specific laboratory tests are recommended for monitoring during the use of nitrogen. However, healthcare professionals should remain vigilant and prepared to respond to any adverse effects or emergencies that may arise during its administration.

Side Effects

Administration of nitrogen may be hazardous or contraindicated. The extremely cold liquid and gas under pressure can cause rapid suffocation and severe frostbite.

In clinical settings, if nitrogen is inhaled, it is crucial to remove the patient to fresh air immediately. If the patient is not breathing, artificial respiration should be administered. In cases where breathing is difficult, oxygen should be provided, and a physician must be contacted without delay. In the event of frostbite, obtaining medical treatment immediately is essential to mitigate potential complications.

Drug Interactions

Administration of nitrogen may pose significant risks and is contraindicated in certain situations. Healthcare professionals should exercise caution when considering the use of nitrogen in conjunction with other therapies, as its administration may lead to adverse effects.

No specific drug or laboratory test interactions have been identified in the available data. Therefore, routine monitoring for interactions with other medications or laboratory tests is not deemed necessary at this time.

Packaging & NDC

The table below lists all NDC Code configurations of Nitrogen, the U.S. brand-name prescription product. Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Nitrogen.
Details

Pediatric Use

Administration of nitrogen in pediatric patients may be hazardous or contraindicated. It is essential that nitrogen is used only by or under the supervision of a licensed practitioner who has experience in its use and administration. This practitioner must be familiar with the indications, effects, dosages, methods, frequency, duration of administration, as well as the associated hazards, contraindications, side effects, and necessary precautions. Careful consideration and adherence to these guidelines are critical to ensure the safety and efficacy of nitrogen use in children.

Geriatric Use

There is no specific information regarding the use of this medication in geriatric patients, including age considerations, dosage adjustments, safety concerns, or special precautions. Healthcare providers should exercise caution when prescribing this medication to elderly patients, as the absence of data necessitates careful monitoring and individualized assessment of treatment risks and benefits in this population.

Pregnancy

Administration of nitrogen during pregnancy may pose significant risks and is generally considered hazardous or contraindicated. Pregnant patients should only receive nitrogen under the supervision of a licensed practitioner who is experienced in its use and administration.

The use of nitrogen involves exposure to extremely cold liquid and gas under pressure, which can lead to rapid suffocation and severe frostbite. Due to these potential hazards, healthcare professionals are advised to exercise caution and ensure that appropriate safety measures are in place when considering the use of nitrogen in pregnant patients.

It is essential that the product label remains intact and is not removed, as it contains critical safety information.

Lactation

There are no specific statements or information regarding nursing mothers or lactation in the provided drug insert for Nitrogen. Therefore, the effects on breastfed infants and the excretion of Nitrogen in breast milk remain undetermined. Healthcare professionals should consider this lack of data when advising lactating mothers on the use of this medication.

Renal Impairment

Patients with renal impairment have not been specifically addressed in the available prescribing information. There are no dosage adjustments, special monitoring requirements, or safety considerations outlined for individuals with reduced kidney function. Healthcare professionals should exercise caution and consider the lack of data when prescribing to this patient population.

Hepatic Impairment

Patients with hepatic impairment have not been specifically studied in relation to the use of Nitrogen. Consequently, there is no available information regarding dosage adjustments, special monitoring requirements, or precautions for this population. It is recommended that healthcare providers exercise caution when prescribing Nitrogen to patients with compromised liver function, given the lack of data on its safety and efficacy in this group. Regular monitoring of liver function may be prudent in these cases, although specific parameters are not outlined in the prescribing information.

Overdosage

Administration of nitrogen can pose significant risks and may be contraindicated in certain situations. It is imperative that nitrogen is used solely by or under the supervision of a licensed practitioner who possesses expertise in its administration. This practitioner should be well-versed in the indications, effects, dosages, methods, frequency, duration of administration, as well as the associated hazards, contraindications, side effects, and necessary precautions.

Nitrogen is characterized as an extremely cold liquid and gas under pressure, which can lead to rapid suffocation and severe frostbite if mishandled. In the event of inhalation, the individual should be promptly removed to an area with fresh air. If the individual is not breathing, artificial respiration should be administered immediately. Should breathing difficulties arise, supplemental oxygen must be provided. It is crucial to contact a physician for further evaluation and management. In cases of frostbite, immediate medical treatment is essential to mitigate potential tissue damage.

Nonclinical Toxicology

No information is available regarding teratogenic or non-teratogenic effects. Additionally, there is no data provided concerning nonclinical toxicology, animal pharmacology, or toxicology.

Postmarketing Experience

Postmarketing experience has revealed that this drug has not been found by the FDA to be safe and effective, and its labeling has not received FDA approval.

Warnings associated with the drug indicate that the administration of nitrogen may be hazardous or contraindicated. Additionally, it is noted that the substance is extremely cold, exists as a liquid and gas under pressure, and can lead to rapid suffocation and severe frostbite.

In cases of inhalation, it is advised to remove the individual to fresh air. If the individual is not breathing, artificial respiration should be administered. If breathing difficulties arise, oxygen should be provided, and a physician should be contacted. In instances of frostbite, immediate medical treatment is essential.

Patient Counseling

Healthcare providers should advise patients to always keep the container in an upright position to ensure safe handling and usage. It is important to instruct patients not to change or force fit connections, as this may lead to hazardous situations.

Providers must communicate the significant warnings associated with the administration of nitrogen. They should emphasize that nitrogen administration may be hazardous or contraindicated and is intended for use only by or under the supervision of a licensed practitioner who is experienced in its use. This practitioner should be familiar with the indications, effects, dosages, methods, frequency, duration of administration, as well as the hazards, contraindications, side effects, and necessary precautions.

Patients should be made aware that nitrogen is extremely cold and exists as a liquid and gas under pressure, which can cause rapid suffocation and severe frostbite. It is crucial to store and use nitrogen with adequate ventilation and to avoid contact with eyes, skin, or clothing. When withdrawing liquid nitrogen, patients should wear a face shield and gloves to protect against potential exposure. They should also be instructed not to drop the container and to use a suitable hand truck for movement. Additionally, the cylinder temperature should not exceed 52°C (125°F), and the valve should be closed after each use and when empty. A backflow preventative device should be used in the piping, and all handling should be in accordance with the Material Safety Data Sheet (MSDS).

In the event of an emergency, healthcare providers should inform patients of the first aid measures to take if nitrogen is inhaled. Patients should be instructed to remove themselves to fresh air immediately. If the patient is not breathing, artificial respiration should be administered, and if breathing is difficult, oxygen should be provided. It is essential to call a physician in such cases. In the event of frostbite, patients should seek medical treatment immediately.

Storage and Handling

The product is supplied in a container that must always be kept in an upright position. It is essential to avoid changing or forcing any connections. Adequate ventilation is required during storage and use to ensure safety. Care should be taken to prevent any liquid from coming into contact with eyes, skin, or clothing. When withdrawing liquid, personnel must wear a face shield and gloves to protect against exposure.

To maintain the integrity of the container, it should not be dropped, and a suitable hand truck should be utilized for movement. The temperature of the cylinder must not exceed 52°C (125°F). After each use and when the container is empty, the valve should be closed to prevent any leaks. Additionally, a backflow preventative device should be installed in the piping to ensure safe operation. All handling and usage should be conducted in accordance with the Material Safety Data Sheet (MSDS) to ensure compliance with safety protocols.

Additional Clinical Information

The route of administration for the medication is via respiratory inhalation. There are no additional details available regarding laboratory tests, abuse information, patient counseling, or postmarketing experience.

FDA Insert (PDF)

This document is the official FDA-approved prescribing information for Nitrogen as submitted by Specialty Gases of America LLC. It includes detailed information about indications, dosage, contraindications, warnings, and clinical pharmacology.

View full prescribing information (PDF)

Data Generation & Sources

This page was automatically generated and is maintained by the AllDrugs AI Data-Science Team. It was built from the FDA Structured Product Label (DailyMed) for Nitrogen, retrieved by a validated AI data-extraction workflow.

All FDA-approved dosage forms and strengths are listed in the Packaging & NDC Codes section above. Regulatory status, pharmacologic class (EPC), and mechanism of action (MoA) were cross-checked against the FDA Orange Book () and the NSDE NDC Directory daily file.

Note: an automated daemon monitors NSDE checksums; when the record for this NDC changes, the new file is pulled instantly and this page is refreshed.

No human clinician has reviewed this version.

Learn more in our Editorial Policy

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Primary FDA sources:

Orange Book data shown on this page are limited to Regulatory Status (Rx), Established Pharmacologic Class (EPC), and Mechanism of Action (MoA).

Regulatory data notice: Information on this page is reproduced verbatim from FDA public databases (NSDE, Orange Book, Purple Book, DailyMed SPL). NDA/ANDA drugs are FDA-approved, BLA biologics are FDA-licensed. Inclusion alone does not guarantee current market availability or imply FDA endorsement.

Medical disclaimer: This AI-generated content is provided for educational purposes only and does not constitute medical advice. Always consult a licensed healthcare professional for diagnosis or treatment decisions.