Nitrogen

Description

Nitrogen, compressed NF, is a non-flammable gas classified under UN1066. It is available by prescription only and has a Chemical Abstracts Service (CAS) number of 7727-37-9. The gas is supplied in cylinders by US Gas, located at 11618 S Mayfield Ave, Alsip, IL 60803, with a contact number of 708-389-1402.

Uses and Indications

This drug is indicated for use in specific medical situations where the administration of Nitrogen is deemed necessary. It is essential that this drug be administered only by or under the supervision of a licensed practitioner who possesses expertise in the use and administration of Nitrogen. The practitioner must be knowledgeable about the indications, effects, dosages, methods, frequency, and duration of administration, as well as the associated hazards, contraindications, side effects, and necessary precautions.

Limitations of use include the potential hazards associated with Nitrogen administration, which may render it contraindicated in certain circumstances. There are no specific teratogenic or nonteratogenic effects reported for this drug.

Dosage and Administration

Administration of Nitrogen is to be conducted only by or under the supervision of a licensed practitioner experienced in its use. It is essential that the practitioner is familiar with the indications, effects, dosages, methods, and frequency and duration of administration, as the use of Nitrogen may pose hazards or be contraindicated.

Nitrogen is administered via the respiratory route through inhalation. The active ingredient concentration is 900 mL of Nitrogen in a total volume of 1 L. Practitioners should ensure that the administration technique is appropriate and that the patient is monitored throughout the process to mitigate any potential risks associated with the inhalation of Nitrogen.

Contraindications

Administration of Nitrogen is contraindicated in individuals who are not under the supervision of a licensed practitioner experienced in its use. Due to the potential hazards associated with its administration, it is essential that only qualified healthcare professionals who are familiar with the indications, effects, dosages, methods, and precautions related to Nitrogen handle this substance.

Additionally, Nitrogen should not be used in enclosed spaces; it must be utilized and stored outdoors or in well-ventilated areas to mitigate risks of asphyxiation or other adverse effects. Users must also refrain from altering or forcing connections during handling, and in the event of skin contact, the affected area should not be rubbed. All safety precautions must be thoroughly read and understood prior to handling.

Warnings and Precautions

Administration of Nitrogen may pose significant hazards and is contraindicated in certain situations. It is imperative that this substance is used solely by or under the supervision of a licensed practitioner who possesses experience in the use and administration of Nitrogen. This practitioner must be well-versed in the indications, effects, dosages, methods, frequency, duration of administration, as well as the associated hazards, contraindications, side effects, and necessary precautions.

Warnings

Nitrogen is classified as a gas under pressure and may explode if subjected to heat. It has the potential to displace oxygen, leading to rapid suffocation. Therefore, it is crucial to read and understand all safety precautions before handling. Nitrogen should only be used and stored outdoors or in a well-ventilated area.

Additionally, Nitrogen is a refrigerated gas that can cause cryogenic burns or injuries. Similar to the previous warning, it may also displace oxygen and cause rapid suffocation. Proper protective equipment, including cold insulating gloves, a face shield, and eye protection, should be worn when handling this gas.

General Precautions

To ensure safe use, a backflow preventive device must be employed in the piping system. Nitrogen should only be utilized with equipment that is rated for cylinder pressure. It is essential to close the valve after each use and when the cylinder is empty. Containers should be protected from sunlight, particularly when ambient temperatures exceed 52 degrees Celsius (125 degrees Fahrenheit). Prior to use, the Safety Data Sheet (SDS) must be read and followed meticulously.

Connections should never be changed or forced to fit, and the container must always be maintained in an upright position.

Emergency Medical Help Instructions

In the event of inhalation, the affected individual should be removed to fresh air and kept comfortable for breathing. Immediate medical advice and attention should be sought.

Stop Taking and Call Your Doctor Instructions

If Nitrogen comes into contact with the skin, it is critical to thaw any frostbitten areas with lukewarm water without rubbing the affected area. Immediate medical advice and attention should be obtained.

Side Effects

Administration of Nitrogen may pose significant risks and is contraindicated in certain situations. It is essential that Nitrogen is used only by or under the supervision of a licensed practitioner who possesses experience in its use and administration. This practitioner should be well-versed in the indications, effects, dosages, methods, frequency and duration of administration, as well as the associated hazards, contraindications, side effects, and necessary precautions.

Serious adverse reactions associated with Nitrogen include the potential for rapid suffocation due to oxygen displacement. This risk is particularly pertinent in environments where Nitrogen is used, as it can lead to life-threatening situations if not properly managed. Additionally, contact with refrigerated liquid nitrogen can result in cryogenic burns or injury, necessitating immediate medical attention.

In the event of inhalation, it is critical to remove the affected individual to fresh air and ensure they are comfortable for breathing. Medical advice or attention should be sought promptly. If skin contact occurs, it is advised to thaw any frosted areas with lukewarm water without rubbing the affected skin, and immediate medical advice or attention should be obtained.

Overall, the administration of Nitrogen carries inherent risks that require careful consideration and management to prevent serious adverse outcomes.

Drug Interactions

Administration of Nitrogen may pose significant risks and is contraindicated in certain situations. It is essential that Nitrogen is used exclusively by or under the supervision of a licensed practitioner who possesses experience in its use and administration. This practitioner should be well-versed in the indications, effects, dosages, methods, frequency, duration of administration, as well as the associated hazards, contraindications, side effects, and necessary precautions.

Currently, there are no specific drug or laboratory test interactions identified in the available data. Therefore, no additional monitoring or dosage adjustments are required in relation to other medications or laboratory tests.

Packaging & NDC

The table below lists all NDC Code configurations of Nitrogen, the U.S. brand-name prescription product. Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Pediatric Use

The administration of Nitrogen in pediatric patients may pose hazards or be contraindicated. It is essential that Nitrogen is used only by or under the supervision of a licensed practitioner who has experience in its use and administration. Currently, there are no specific dosing recommendations or age limits established for pediatric patients. Caution is advised when considering the use of this agent in children, infants, or adolescents.

Geriatric Use

There is no specific information regarding the use of Nitrogen in geriatric patients, including recommended age considerations, dosage adjustments, safety concerns, or special precautions. Therefore, healthcare providers should exercise caution when prescribing this medication to elderly patients, as the absence of data necessitates careful monitoring and individualized assessment of treatment risks and benefits in this population.

Pregnancy

Administration of Nitrogen during pregnancy may pose potential risks to both the pregnant patient and the developing fetus. The use of Nitrogen is contraindicated or may be hazardous, and it is recommended that it be administered only by or under the supervision of a licensed practitioner experienced in its use.

Healthcare professionals should exercise caution when considering the use of Nitrogen in pregnant patients, as the implications for fetal outcomes are not fully understood. Given the potential hazards associated with its administration, it is essential to weigh the benefits against the risks before proceeding with treatment in this population.

Lactation

There is no specific information available regarding the use of this medication in nursing mothers or any considerations related to lactation. Healthcare professionals should exercise caution and consider the potential risks and benefits when prescribing this medication to lactating mothers. The effects on breastfed infants have not been established, and further data may be necessary to inform clinical decisions.

Renal Impairment

Patients with renal impairment have not been specifically addressed in the available data regarding dosage adjustments, special monitoring, or safety considerations. Therefore, healthcare professionals should exercise caution when prescribing this medication to patients with reduced kidney function, as the lack of information necessitates careful clinical judgment and monitoring.

Hepatic Impairment

Patients with hepatic impairment have not been specifically studied in clinical trials for this medication. Consequently, there is no available information regarding dosage adjustments, special monitoring requirements, or precautions for individuals with compromised liver function. It is recommended that healthcare providers exercise caution when prescribing this medication to patients with hepatic impairment, given the lack of data on its safety and efficacy in this population. Regular monitoring of liver function may be warranted based on clinical judgment.

Overdosage

Administration of Nitrogen may pose significant hazards and is contraindicated in certain situations. It is imperative that Nitrogen is used solely by or under the supervision of a licensed practitioner who possesses experience in its use and administration. This practitioner should be well-versed in the indications, effects, dosages, methods, frequency, duration of administration, as well as the associated hazards, contraindications, side effects, and necessary precautions.

Warnings

Nitrogen is classified as a gas under pressure, which presents a risk of explosion if subjected to heat. Additionally, it has the potential to displace oxygen in the environment, leading to rapid suffocation. Furthermore, the presence of refrigerated gas can result in cryogenic burns or injuries.

First Aid Measures

In the event of inhalation, it is crucial to remove the affected individual to an area with fresh air and ensure they are comfortable while breathing. Medical advice or attention should be sought immediately.

If Nitrogen comes into contact with the skin, it is essential to thaw any frosted areas using lukewarm water. Rubbing the affected area should be avoided, and immediate medical advice or attention must be obtained to address potential injuries.

Healthcare professionals must remain vigilant regarding the risks associated with Nitrogen overdosage and be prepared to implement appropriate management procedures.

Nonclinical Toxicology

No teratogenic or non-teratogenic effects have been reported in the available nonclinical studies. Additionally, there is no information regarding animal pharmacology and toxicology. The absence of data limits the assessment of potential risks associated with the compound in these areas.

Postmarketing Experience

No specific postmarketing experience details have been reported. As such, there are no additional adverse events or rare case reports to summarize at this time.

Patient Counseling

Healthcare providers should advise patients that the administration of Nitrogen may pose hazards or be contraindicated. It is essential that Nitrogen is used only by or under the supervision of a licensed practitioner who is experienced in its use and administration. Patients should be informed that the practitioner must be familiar with the indications, effects, dosages, methods, frequency and duration of administration, as well as the associated hazards, contraindications, side effects, and necessary precautions.

Providers must emphasize the warning that Nitrogen contains gas under pressure, which may explode if heated. Patients should be made aware that it can displace oxygen and cause rapid suffocation. It is crucial that patients do not handle Nitrogen until all safety precautions have been read and understood. They should be instructed to use and store Nitrogen only outdoors or in a well-ventilated area.

Patients should be informed about the importance of using a backflow preventive device in the piping and that Nitrogen should only be used with equipment rated for cylinder pressure. They should be advised to close the valve after each use and when the cylinder is empty, and to protect the cylinder from sunlight when the ambient temperature exceeds 52 degrees Celsius (125 degrees Fahrenheit). It is recommended that patients read and follow the Safety Data Sheet (SDS) before use.

In the event of inhalation, patients should be instructed to remove themselves to fresh air and keep comfortable for breathing. They should seek medical advice or attention if necessary. Additionally, patients should be warned that Nitrogen contains refrigerated gas, which may cause cryogenic burns or injury, and can also displace oxygen, leading to rapid suffocation.

Patients must be reminded not to handle Nitrogen until all safety precautions have been read and understood, and to use and store it only outdoors or in a well-ventilated area. They should wear cold insulating gloves, a face shield, and eye protection when handling Nitrogen.

Providers should also inform patients not to change or force fit connections, to always keep the container in an upright position, and to close the valve after each use and when empty. Again, reading and following the Safety Data Sheet (SDS) before use is strongly advised.

In case of skin contact, patients should be instructed to thaw frosted parts with lukewarm water without rubbing the affected area and to seek immediate medical advice or attention.

Storage and Handling

The product is supplied in containers that must be used and stored exclusively outdoors or in a well-ventilated area. It is essential to protect the product from sunlight when the ambient temperature exceeds 52 degrees Celsius (125 degrees Fahrenheit). After each use and when the container is empty, the valve should be closed to ensure safety.

Containers must always be maintained in an upright position to prevent leaks or spills. When handling the product, personnel are required to wear cold insulating gloves, a face shield, and eye protection to minimize risk. Additionally, a backflow preventive device should be utilized in the piping to ensure safe operation.

Prior to handling, it is crucial to read and understand all safety precautions outlined in the Safety Data Sheet (SDS).

Additional Clinical Information

The route of administration for the medication is via respiratory inhalation. There are no additional details available regarding laboratory tests, abuse information, patient counseling, or postmarketing experience.

FDA Insert (PDF)

This document is the official FDA-approved prescribing information for Nitrogen as submitted by United States Cylinder Gas Corporation. It includes detailed information about indications, dosage, contraindications, warnings, and clinical pharmacology.

View full prescribing information (PDF)