ADD CONDITION
Nitrous oxide
Last content change checked dailysee data sync status
- Active ingredient
- Nitrous Oxide 500–995 mL
- Reference brand
- Nitrous Oxide
- Dosage forms
- Gas
- Liquid
- Routes
- Rectal
- Respiratory (inhalation)
- Prescription status
- Rx (prescription)
- Marketed in the U.S.
- Since 1938
- Label revision date
- February 12, 2026
- Pregnancy
- See Pregnancy Use Section
- Lactation
- See Lactation Use Section
- Active ingredient
- Nitrous Oxide 500–995 mL
- Reference brand
- Nitrous Oxide
- Dosage forms
- Gas
- Liquid
- Routes
- Rectal
- Respiratory (inhalation)
- Prescription status
- Rx (prescription)
- CSA schedule
- Not a scheduled drug
- Marketed in the U.S.
- Since 1938
- Label revision date
- February 12, 2026
- Pregnancy
- See Pregnancy Use Section
- Lactation
- See Lactation Use Section
If you are a healthcare professional or from the pharmaceutical industry please visit this version.
If you are a consumer or patient please visit this version.
Drug Overview
Nitrous Oxide is a non-flammable gas that is classified as an oxidizer and is used primarily in medical settings. It is administered under the supervision of a licensed practitioner who is experienced in its use. Nitrous Oxide can produce anesthetic effects, which means it can help relieve pain and anxiety during medical procedures. However, it is important to note that its administration may be hazardous or contraindicated in certain situations.
This gas is stored under pressure and can be dangerous if not handled properly, as it may explode if heated and can displace oxygen, leading to rapid suffocation. Safety precautions must be followed, including using appropriate equipment and ensuring adequate ventilation. If inhaled, it is crucial to move the person to fresh air and seek medical attention if they feel unwell.
Uses
Nitrous Oxide is a medical gas used primarily as an anesthetic and analgesic agent. It is administered under the supervision of a licensed practitioner who is experienced in its use and familiar with the necessary indications, effects, dosages, and methods of administration. Due to potential hazards, it is crucial that only qualified professionals handle this gas.
It's important to note that Nitrous Oxide can expose you to chemicals known to the state of California to cause birth defects or other reproductive harm. Therefore, if you are pregnant or planning to become pregnant, you should discuss the risks with your healthcare provider before using this gas.
Dosage and Administration
You should only use Nitrous Oxide under the supervision of a licensed practitioner who is experienced in its administration. This gas is administered through inhalation (breathing it in) and is typically provided in a strength of 990 mL in 1 L.
When using Nitrous Oxide, ensure that you are in a well-ventilated area. Open the valve slowly and use equipment that is specifically rated for cylinder pressure. It's important to close the valve after each use and when the cylinder is empty. Additionally, a backflow preventive device should be used in the piping to ensure safety.
What to Avoid
Administration of Nitrous Oxide may be hazardous or contraindicated, and it should only be used under the supervision of a licensed practitioner experienced in its use. You should avoid handling the gas until all safety precautions have been read and understood. Do not breathe the gas, and ensure it does not come into contact with your eyes, skin, or clothing. Always use and store it outdoors or in a well-ventilated area, and do not open the valve until connected to properly cleaned equipment. Additionally, be cautious of spills and avoid walking or rolling equipment over them.
Side Effects
You should be aware that using nitrous oxide can lead to several side effects and serious risks. Common reactions include drowsiness, dizziness, nausea, vomiting, and headaches. More severe effects can include hypoxia (lack of oxygen), respiratory depression, and cardiovascular issues like low blood pressure or slow heart rate. There is also a risk of frostbite if the gas comes into contact with skin, and prolonged exposure may lead to vitamin B12 deficiency.
Nitrous oxide can displace oxygen, which may cause rapid suffocation, and it is classified as an oxidizer, meaning it can intensify fires. Inhalation without sufficient oxygen can be fatal or cause brain damage. If you experience any adverse effects, it is crucial to seek medical attention immediately. Always use nitrous oxide under the supervision of a qualified practitioner.
Warnings and Precautions
Using Nitrous Oxide can be hazardous and should only be done under the supervision of a licensed practitioner familiar with its administration and effects. It is important to avoid breathing the gas, as it can cause drowsiness, dizziness, and may displace oxygen, leading to rapid suffocation. Additionally, it can cause frostbite if it comes into contact with skin.
Always handle Nitrous Oxide with care:
Store and use it outdoors or in well-ventilated areas, away from combustible materials and grease.
Use protective gloves, clothing, and eye protection.
Open the valve slowly and close it after each use.
Protect the cylinder from sunlight and ensure it does not exceed 125°F (52°C).
In case of an emergency:
If inhaled, move to fresh air and seek medical attention if feeling unwell.
For frostbite, thaw affected areas with lukewarm water without rubbing.
Call a POISON CENTER or doctor if you experience any adverse effects.
This product may expose you to chemicals known to cause birth defects or reproductive harm. Always read and follow the Safety Data Sheet (SDS) before use.
Overdose
Breathing pure nitrous oxide can be extremely dangerous and may lead to death by rapid suffocation. If you or someone else is exposed to nitrous oxide and experiences difficulty breathing, confusion, or loss of consciousness, it is crucial to seek immediate medical help. Always ensure that nitrous oxide is used in a safe and controlled environment to prevent any potential risks.
Pregnancy Use
The administration of Nitrous Oxide during pregnancy may pose risks and is generally considered hazardous or contraindicated. It is important to note that Nitrous Oxide has been linked to potential birth defects and other reproductive harm, as recognized by the State of California. Therefore, if you are pregnant, it is crucial to avoid using this gas unless the potential benefits outweigh the risks, and this should only be done under the supervision of a licensed practitioner experienced in its administration.
Safety and efficacy of Nitrous Oxide during pregnancy have not been established, and caution is advised. Always consult with your healthcare provider for personalized advice and to discuss any concerns regarding its use.
Lactation Use
You may be wondering about the use of Nitrous Oxide while breastfeeding. Currently, there are no specific warnings or recommendations regarding its use in nursing mothers, and no information is provided about the potential for Nitrous Oxide to be excreted in breast milk (meaning it could pass into your milk). However, caution is advised, as the safety of Nitrous Oxide during lactation has not been established, and the effects on nursing infants are unknown.
It's important to note that Nitrous Oxide is associated with warnings from the State of California regarding potential birth defects or reproductive harm. If you have concerns, it's best to consult with your healthcare provider for personalized advice.
Pediatric Use
The use of Nitrous Oxide in children has not been specifically detailed, and there are no recommended ages, dosing differences, or special precautions provided. However, it is important to note that the administration of Nitrous Oxide may be hazardous or contraindicated for pediatric patients. Therefore, it should only be used by or under the supervision of a licensed practitioner who is experienced in its use and familiar with the potential risks and side effects, especially in children. Always consult with a healthcare professional before considering its use for your child.
Geriatric Use
Elderly patients may experience increased sensitivity to the effects of Nitrous Oxide, a gas commonly used for sedation and pain relief. It is important to consider that older adults may have reduced kidney function, which can affect how the body processes medications. Due to these factors, dosage adjustments may be necessary to ensure safety and effectiveness. Always consult with a healthcare provider to address any specific safety concerns and to determine the appropriate dosage for elderly patients before administration.
Renal Impairment
When using Nitrous Oxide, there is no specific information available regarding dosage adjustments, monitoring, or safety considerations for individuals with kidney problems. However, it is important to note that renal impairment may require careful attention. If you have kidney issues, your healthcare provider may need to monitor your renal function tests and consider adjusting your dosage, especially if your creatinine clearance is below a certain threshold. Always consult with your healthcare professional for personalized advice and monitoring if you have renal impairment.
Hepatic Impairment
You should be aware that there is no specific information regarding liver problems (hepatic impairment) for Nitrous Oxide, a gas used for anesthesia and pain relief. This means that there are no recommended dosage adjustments, special monitoring, or precautions for individuals with liver issues mentioned in the product information. If you have liver concerns, it's always best to consult your healthcare provider for personalized advice.
Drug Interactions
Nitrous Oxide, commonly known as laughing gas, is administered as a gas and is primarily used for its anesthetic and analgesic properties. Importantly, there are no known drug interactions or laboratory test interactions associated with Nitrous Oxide. However, it is always crucial to discuss any medications or tests you are undergoing with your healthcare provider. This ensures your safety and helps avoid any unforeseen complications, as your provider can give tailored advice based on your specific health needs.
Storage and Handling
To ensure safe storage and handling of nitrous oxide gas, always keep the container in an upright position and store it locked up, away from clothing and other combustible materials. Use and store the gas only outdoors or in a well-ventilated area. Protect it from sunlight, especially when temperatures exceed 52°C (125°F). Keep valves and fittings free from grease and oil, and use only with equipment that is compatible and rated for cylinder pressure, as well as cleaned for oxygen service.
When using the gas, open the valve slowly and close it after each use and when empty. Always use a backflow preventive device in the piping to avoid any hazards. For disposal, follow the instructions provided by the container supplier or owner, and ensure you are familiar with all safety precautions before handling the gas. Avoid breathing in the gas and prevent any contact with skin or eyes.
Uses and Indications
Administration of Nitrous Oxide may be hazardous or contraindicated. It is indicated for use only by or under the supervision of a licensed practitioner who is experienced in the use and administration of Nitrous Oxide and is familiar with the indications, effects, dosages, methods, frequency and duration of administration, as well as the hazards, contraindications, side effects, and precautions to be taken.
Nitrous Oxide is used as a medical gas for anesthetic effects and is administered as a diluent for oxygen to produce respirable mixtures. It is also indicated for analgesic purposes.
Teratogenic Effects
This product contains a chemical known to the state of California to cause birth defects or other reproductive harm.
Nonteratogenic Effects
No specific nonteratogenic effects are mentioned.
Dosage and Administration
Administration of Nitrous Oxide is indicated for use only by or under the supervision of a licensed practitioner who is experienced in its use and administration. Practitioners must be familiar with the indications, effects, dosages, methods, and frequency and duration of administration, as the use of Nitrous Oxide may be hazardous or contraindicated.
The route of administration is via respiratory inhalation. The active ingredient is Nitrous Oxide, with a strength of 990 mL in 1 L. It is essential to use equipment rated for cylinder pressure and to ensure that the equipment is cleaned for oxygen service. The valve should be opened slowly, and a backflow preventive device should be utilized in the piping. The valve must be closed after each use and when the cylinder is empty.
Administration should be conducted in a well-ventilated area to ensure safety.
Contraindications
Administration of Nitrous Oxide may be hazardous or contraindicated. It is recommended for use only by or under the supervision of a licensed practitioner who is experienced in the use and administration of Nitrous Oxide and is familiar with the indications, effects, dosages, methods, and frequency and duration of administration, as well as the hazards, contraindications, and side effects, and the precautions to be taken.
Inhalation of Nitrous Oxide without sufficient oxygen supply may be fatal or cause brain damage. Additionally, it is contraindicated to handle the gas until all safety precautions have been read and understood. Users should avoid breathing the gas and ensure that it does not come into contact with eyes, skin, or clothing. It is advised to use and store the gas only outdoors or in a well-ventilated place, and to avoid spills.
Warnings and Precautions
Administration of Nitrous Oxide may be hazardous or contraindicated. It is intended for use only by or under the supervision of a licensed practitioner who is experienced in the use and administration of Nitrous Oxide and is familiar with the indications, effects, dosages, methods, and frequency and duration of administration, as well as the hazards, contraindications, side effects, and precautions to be taken.
Warnings
DANGER: May cause or intensify fire; oxidizer. Contains gas under pressure; may explode if heated.
May cause drowsiness or dizziness.
May displace oxygen and cause rapid suffocation.
May cause frostbite.
This product can expose you to chemicals including Nitrous Oxide, which is known to the State of California to cause birth defects or other reproductive harm.
General Precautions
Do not handle until all safety precautions have been read and understood.
Keep and store away from clothing and other combustible materials.
Keep valves and fittings free from grease and oil.
Avoid breathing gas. Do not get in eyes, on skin, or on clothing.
Use and store only outdoors or in a well-ventilated place.
Wear protective gloves, protective clothing, and either eye or face protection.
In case of fire: Stop leak if safe to do so.
Store locked up. Dispose of contents/container in accordance with container supplier/owner instructions.
Use a back flow preventive device in the piping.
Close valve after each use and when empty.
Use only with equipment of compatible materials of construction and rated for cylinder pressure.
Use only with equipment cleaned for oxygen service.
Open valve slowly.
Protect from sunlight when ambient temperature exceeds 52°C (125°F).
Read and follow the Safety Data Sheet (SDS) before use.
Laboratory Tests
No specific laboratory tests are mentioned for safe use.
Get Emergency Medical Help Instructions
Call a POISON CENTER or doctor/physician if you feel unwell.
If inhaled, remove the person to fresh air and keep comfortable for breathing. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Call a physician.
In case of frostbite, obtain immediate medical treatment.
Stop Taking and Call Your Doctor Instructions
If on skin: Thaw frosted parts with lukewarm water. Do not rub affected area. Get immediate medical advice/attention.
Side Effects
Serious Adverse Reactions:
Hypoxia
Respiratory depression
Cardiovascular effects (e.g., hypotension, bradycardia)
Neurological effects (e.g., peripheral neuropathy, myeloneuropathy)
Severe allergic reactions (e.g., anaphylaxis)
Cardiac arrest
Common Adverse Reactions:
Dizziness
Nausea
Vomiting
Headache
Sedation
Euphoria
Less Common Adverse Reactions:
Hallucinations
Anxiety
Confusion
Drowsiness
Dysphoria
Rare Adverse Reactions:
Neuropathy
Megaloblastic anemia
Bone marrow suppression
Vitamin B12 deficiency with prolonged exposure
Warnings:
Administration of Nitrous Oxide may be hazardous or contraindicated.
May cause or intensify fire; oxidizer.
May cause drowsiness or dizziness.
May displace oxygen and cause rapid suffocation.
May cause frostbite.
Inhalation of Nitrous Oxide without sufficient oxygen supply may be fatal or cause brain damage.
Postmarketing Experience:
Reports of abuse and dependence.
Increased intracranial pressure.
Risk of diffusion hypoxia after discontinuation of nitrous oxide.
First Aid:
If inhaled: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER or doctor/physician if unwell.
If on skin: Thaw frosted parts with lukewarm water. Do not rub affected area. Get immediate medical advice/attention.
Drug Interactions
Nitrous Oxide, available in gas form, has no documented drug interactions or interactions with laboratory tests across multiple sources. All reviewed labels consistently indicate the absence of any known interactions, suggesting that Nitrous Oxide can be used without concern for potential drug-drug or drug-laboratory test interactions.
Pediatric Use
Pediatric use of Nitrous Oxide has not been specifically addressed in the available literature. There are no recommended ages, dosing differences, or specific safety concerns for children mentioned.
Administration of Nitrous Oxide may be hazardous or contraindicated in pediatric patients. It is advised that Nitrous Oxide be used only by or under the supervision of a licensed practitioner who is experienced in its use and administration. This practitioner should be familiar with the indications, effects, dosages, methods, frequency and duration of administration, as well as the hazards, contraindications, side effects, and precautions to be taken, particularly in pediatric patients.
Special precautions should be taken when administering Nitrous Oxide to children due to potential risks. Additionally, there is a warning that this product can expose individuals to chemicals, including Nitrous Oxide, which is known to the State of California to cause birth defects or other reproductive harm.
Geriatric Use
Elderly patients may exhibit increased sensitivity to the effects of nitrous oxide. It is important to consider the potential for reduced kidney function in this population, which may necessitate dosage adjustments due to age-related physiological changes. Safety concerns specific to elderly patients should be addressed prior to administration. While no specific geriatric use considerations, dosage adjustments, or special precautions are universally outlined in the available data, healthcare providers should remain vigilant and tailor their approach based on individual patient assessments.
Pregnancy
Administration of Nitrous Oxide may be hazardous or contraindicated in pregnant patients. The safety and efficacy of Nitrous Oxide during pregnancy have not been established, and it is contraindicated due to potential risks to the fetus. There is a warning that exposure to Nitrous Oxide is known to the State of California to cause birth defects or other reproductive harm.
Caution is advised when considering the use of Nitrous Oxide in pregnant patients. It should only be administered by or under the supervision of a licensed practitioner experienced in its use. The potential benefits must be carefully weighed against the risks to the fetus. Special precautions should be taken, and the administration of Nitrous Oxide during labor and delivery should be considered with caution due to its potential effects on fetal outcomes.
In summary, the use of Nitrous Oxide in pregnancy is not recommended unless absolutely necessary, and practitioners should remain vigilant regarding the associated risks.
Lactation
There are no specific warnings or recommendations regarding the use of Nitrous Oxide in nursing mothers. The safety of Nitrous Oxide during lactation has not been established, and caution should be exercised when administering it to nursing mothers.
Additionally, there is a potential for excretion in breast milk; however, the effects on breastfed infants are unknown. Healthcare professionals should consider these factors when advising lactating mothers on the use of this product.
It is important to note that Nitrous Oxide is known to the State of California to cause birth defects or other reproductive harm, which may be relevant for lactating mothers.
Renal Impairment
Patients with renal impairment may require careful consideration when using Nitrous Oxide. While the majority of available labels do not provide specific information regarding dosage adjustments, monitoring, or safety considerations for this patient population, one label indicates that renal impairment may necessitate dosage adjustments.
It is advised to monitor renal function tests in patients with renal impairment, particularly for those with severe renal impairment. Additionally, a reduced dose should be considered for patients with a creatinine clearance below a specified threshold. Special monitoring is recommended for these patients to ensure safety and efficacy during treatment.
Overall, healthcare providers should exercise caution and evaluate the renal function of patients prior to administering Nitrous Oxide, taking into account the potential need for adjustments and enhanced monitoring.
Hepatic Impairment
No specific information regarding hepatic impairment, dosage adjustments, special monitoring, or precautions for patients with liver problems is provided in the drug insert for Nitrous Oxide. This includes the Nitrous Oxide Oxygen Mix formulation. Therefore, no alterations to dosing or monitoring protocols are recommended for patients with hepatic impairment.
Overdosage
In the event of an overdose involving nitrous oxide, it is important to note that specific overdosage information is not provided in the available literature. However, caution is warranted, as breathing pure nitrous oxide can lead to serious consequences, including death by rapid suffocation.
Management of potential overdosage should focus on immediate intervention. If exposure occurs, the individual should be moved to an area with fresh air to ensure adequate oxygen supply. Continuous monitoring of respiratory function and vital signs is recommended, as hypoxia may develop due to displacement of oxygen in the lungs.
In cases of severe respiratory distress or loss of consciousness, emergency medical services should be contacted immediately. Supportive care, including supplemental oxygen, may be necessary to restore adequate oxygenation.
Due to the lack of specific symptoms associated with nitrous oxide overdosage, vigilance in monitoring for signs of hypoxia or respiratory failure is essential.
Nonclinical Toxicology
Teratogenic Effects
Animal studies have not reported any teratogenic effects associated with nitrous oxide exposure. Additionally, adverse developmental outcomes were not observed in these studies.
Non-Teratogenic Effects
No significant non-teratogenic effects have been documented in animal studies related to nitrous oxide.
Carcinogenesis, Mutagenesis, Impairment of Fertility
There is no available information regarding the carcinogenic or mutagenic potential of nitrous oxide. Furthermore, data on the impairment of fertility due to nitrous oxide exposure is not provided.
Animal Toxicology
Animal studies did not demonstrate any significant toxic effects related to nitrous oxide exposure. However, it is important to note that this product can expose individuals to chemicals, including nitrous oxide, which is known to the State of California to cause birth defects or other reproductive harm. For further information, individuals are directed to visit www.P65Warnings.ca.gov.
Storage and Handling
Nitrous Oxide is supplied as a gas and must be handled with care to ensure safety and compliance with storage requirements.
Storage Conditions:
Store locked up and away from clothing and other combustible materials.
Keep the container in an upright position at all times.
Protect from sunlight when ambient temperature exceeds 52°C (125°F).
Store and use only outdoors or in a well-ventilated place.
Store in a cool, dry place, avoiding exposure to heat or flame.
Dispose of contents/container in accordance with local, regional, national, or international regulations.
Handling Requirements:
Always keep valves and fittings free from grease and oil.
Use only with equipment that is rated for cylinder pressure and cleaned for oxygen service.
Open the valve slowly and close it after each use and when empty.
Use a back flow preventive device in the piping to prevent backflow.
Avoid breathing gas and do not allow liquid to come into contact with eyes, skin, or clothing.
Wear appropriate protective gear, including cold insulating gloves, face shield, and eye protection.
Do not handle until all safety precautions have been read and understood.
Avoid spills; do not walk on or roll equipment over spills.
Following these guidelines will help ensure safe storage and handling of Nitrous Oxide.
Product Labels
The table below lists all FDA-approved prescription labels containing nitrous oxide. Use it to compare dosage forms, strengths, and approved indications across labels.
More Details | |||||
|---|---|---|---|---|---|
ABCO Welding and Industrial Supply Inc. | Gas | Respiratory (inhalation) | 990 mL/1 L | 2010 | |
| |||||
Aero All Gas Company | Gas | Respiratory (inhalation) | 990 mL/1 L | 1972 | |
| |||||
AGL Welding Supply Co. , Inc. | Gas | Respiratory (inhalation) | 990 mL/1 L | 1966 | |
| |||||
AGP LLC | Gas | Respiratory (inhalation) | 990 mL/1 L | 2024 | |
| |||||
Air Source Industries | Gas | Respiratory (inhalation) | 99 L/100 L | 1992 | |
| |||||
Airgas East, Inc. | Gas | Respiratory (inhalation) | 990 mL/1 L | 1991 | |
| |||||
Airgas Intermountain Inc | Gas | Respiratory (inhalation) | 992 mL/1 L | 1985 | |
Indications
| |||||
Airgas Northern California and Nevada, Inc. | Gas | Respiratory (inhalation) | 992 mL/1 L | 1965 | |
| |||||
AIRGAS USA, LLC | Gas | Respiratory (inhalation) | 992 mL/1 L | 1997 | |
| |||||
Airgas-West, Inc. | Gas | Respiratory (inhalation) | 992 mL/1 L | 1947 | |
| |||||
Airtec Gases, LLC | Gas | Respiratory (inhalation) | 99 L/100 L | 2004 | |
| |||||
American Welding & Gas | Gas | Respiratory (inhalation) | 990 mL/1 L | 2014 | |
| |||||
Analgesic Services Inc | Gas | Respiratory (inhalation) | 992 mL/1 L | 2021 | |
| |||||
Badger Welding Supplies, Inc. | Gas | Respiratory (inhalation) | 99 L/100 L | 1955 | |
| |||||
Boggs Gases div. Boggs Fire Equipment | Gas | Respiratory (inhalation) | 99 L/100 L | 2000 | |
| |||||
Capweld Inc | Gas | Respiratory (inhalation) | 99 L/100 L | 1952 | |
| |||||
Central Welding Supply Company | Gas | Respiratory (inhalation) | 990 mL/1 L | 2016 | |
| |||||
Compressed Gases Inc | Gas | Respiratory (inhalation) | 99 L/100 L | 1980 | |
| |||||
Corrigan Propane LLC dba Blue Water Industrial Products | Gas | Respiratory (inhalation) | 99 L/100 L | 2008 | |
| |||||
Crumpton Welding Supply & Equipment, Inc. | Gas | Respiratory (inhalation) | 99 L/100 L | 1990 | |
| |||||
DJB Gas Services, Inc | Gas | Respiratory (inhalation) | 990 mL/1 L | 2016 | |
| |||||
DuPuy Oxygen & Supply Company, Inc. | Gas | Respiratory (inhalation) | 990 mL/1 L | 1954 | |
| |||||
Encompass Medical & Specialty Gases, Ltd. | Gas | Rectal | 990 mL/1 L | 2008 | |
| |||||
FULLERTON WELDING SUPPLY | Gas | Respiratory (inhalation) | 990 mL/1 L | 2008 | |
| |||||
Fullerton Welding Supply | Gas | Respiratory (inhalation) | 99 L/100 L | 2008 | |
| |||||
General Air Service & Supply Co | Gas | Respiratory (inhalation) | 995 mL/1 L | 1976 | |
| |||||
General Welding Supply Corp. | Gas | Respiratory (inhalation) | 990 mL/1 L | 1984 | |
| |||||
Helget Gas Products | Gas | Respiratory (inhalation) | 995 mL/1 L | 1983 | |
| |||||
Holston Gases, Inc | Gas | Respiratory (inhalation) | 99 kg/100 kg | 1958 | |
| |||||
Holston Gases, Inc | Gas | Respiratory (inhalation) | 99 kg/100 kg | 1958 | |
| |||||
ILMO Products Company | Gas | Respiratory (inhalation) | 990 mL/1 L | 2012 | |
| |||||
Industrial Gas Distributors Inc | Gas | Respiratory (inhalation) | 990 mL/1 L | 2002 | |
| |||||
Inland Welding Supply dba A-L Compressed Gases | Gas | Respiratory (inhalation) | 995 mL/1 L | 2005 | |
| |||||
Keen Compressed Gas Co. Inc. | Gas | Respiratory (inhalation) | 99 L/100 L | 2019 | |
| |||||
Lessors, Incorporated | Gas | Respiratory (inhalation) | 990 mL/1 L | 1964 | |
| |||||
Linde Gas & Equipment Inc. | Gas | Respiratory (inhalation) | 990 mL/1 L | 2007 | |
Indications
| |||||
Machine & Welding Supply Company dba Arc3 Gases South | Gas | Respiratory (inhalation) | 990 mL/1 L | 1990 | |
| |||||
Matheson Tri-Gas, Inc. | Gas | Respiratory (inhalation) | 992 mL/1 L | 1987 | |
| |||||
MAVERICK OXYGEN & RESPIRATORY EQUIPMENT, LLC | Gas | Respiratory (inhalation) | 990 mL/1 L | 2019 | |
| |||||
MEDICAL-TECHNICAL GASES, INC. | Gas | Respiratory (inhalation) | 995 mL/1 L | 1963 | |
| |||||
Metro Welding Supply Corporation | Gas | Respiratory (inhalation) | 990 mL/1 L | 2015 | |
| |||||
MITCHELL WELDING SUPPLY | Gas | Respiratory (inhalation) | 990 mL/1 L | 2018 | |
| |||||
NEXAIR, LLC | Gas | Respiratory (inhalation) | 990 mL/1 L | 1996 | |
| |||||
Nitrous Oxide | Gas | Respiratory (inhalation) | 990 mL/1 L | 2000 | |
| |||||
Nitrous Oxide of Canada | Gas | Respiratory (inhalation) | 900 mL/1 L | 2000 | |
| |||||
NLR Welding Supply, Inc. | Gas | Respiratory (inhalation) | 99 L/100 L | 1986 | |
| |||||
Norco, Inc | Gas | Respiratory (inhalation) | 99 L/100 L | 2008 | |
| |||||
Nordan Smith Welding Supply | Gas | Respiratory (inhalation) | 990 mL/1 L | 1995 | |
| |||||
Oxarc, LLC | Gas | Respiratory (inhalation) | 990 mL/1 L | 1977 | |
| |||||
Praxair Distribution Southeast LLC | Gas | Respiratory (inhalation) | 990 mL/1 L | 2007 | |
| |||||
Praxair Mexico, S. de R. L. de C. V | Gas | Respiratory (inhalation) | 990 mL/1 L | 2017 | |
| |||||
PURITY CYLINDER GASES INC | Gas | Respiratory (inhalation) | 99 L/100 L | 1938 | |
| |||||
Quality Air Products Inc | Gas | Respiratory (inhalation) | 990 mL/1 L | 2009 | |
Indications
| |||||
Red Ball Oxygen Co. , Inc. | Gas | Respiratory (inhalation) | 992 mL/1 L | 1986 | |
| |||||
Roberts Oxygen Company, Inc. | Gas | Respiratory (inhalation) | 990 mL/1 L | 1967 | |
| |||||
Roberts Oxygen Company, Inc. | Gas | Respiratory (inhalation) | 990 mL/1 L | 1967 | |
| |||||
Spectrum Gas Products, Inc | Gas | Respiratory (inhalation) | 99 L/100 L | 2005 | |
| |||||
United States Welding, Inc. | Gas | Respiratory (inhalation) | 99 kg/100 kg | 1970 | |
Indications
| |||||
Volunteer Welding Supply Inc | Gas | Respiratory (inhalation) | 99 L/100 L | 1973 | |
Indications
| |||||
Welding & Therapy Service Inc. | Liquid | Respiratory (inhalation) | 99 L/100 L | 1971 | |
| |||||
Welding & Therapy Service, Inc | Gas | Respiratory (inhalation) | 99 L/100 L | 1971 | |
| |||||
Westair Gases & Equipment, Inc. | Gas | Respiratory (inhalation) | 995 mL/1 L | 2000 | |
| |||||
Roberts Oxygen Company, Inc. | Gas | Respiratory (inhalation) | 500 mL/1 L | 2025 | |
| |||||
Repacked & Relabeled Product Labels
The table below lists products marketed under repackaged or relabeled National Drug Codes (NDCs).
Only the carton or labeler has changed; the underlying FDA-approved SPL and prescribing information match the primary labels above, so no separate detail pages are provided.
The table below lists all NDC Code configurations of Nitrous Oxide, the U.S. brand-name prescription product. Columns show Packaging, Formulation Type, and Active Ingredient Strength.
Label | Forms | Routes | Nitrous Oxide | FDA year |
|---|---|---|---|---|
AIRGAS NOR PAC INC | Gas | Respiratory (inhalation) | 992 mL/1 L | 1983 |
WELSCO, INC. | Gas | Respiratory (inhalation) | 990 mL/1 L | 2012 |
WSM SUPPLIER LLC. | Gas | Respiratory (inhalation) | 992 mL/1 L | 2024 |
All Gas & Welding Supplies Co. , Inc. | Gas | Respiratory (inhalation) | 992 mL/1 L | 2025 |