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Nitrous oxide

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This product has been discontinued

Active ingredient
Nitrous Oxide 99 L/100 L
Other brand names
Dosage form
Gas
Route
Respiratory (inhalation)
Prescription status
Rx (prescription)
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 1952
Label revision date
January 1, 2010
FDA Insert
Prescribing information, PDF file
Active ingredient
Nitrous Oxide 99 L/100 L
Other brand names
Dosage form
Gas
Route
Respiratory (inhalation)
Prescription status
Rx (prescription)
CSA schedule
Not a scheduled drug
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 1952
Label revision date
January 1, 2010
Manufacturer
Capweld Inc
NDC root
52849-500
FDA Insert
Prescribing information, PDF file
Packaging Info (4 NDCs)
Packaging & NDC Codes (4)

If you are a healthcare professional or from the pharmaceutical industry please visit this version.

If you are a consumer or patient please visit this version.

Drug Overview

Nitrous oxide is a compressed gas that is commonly used for its anesthetic effects, making it useful in medical and dental procedures to help relieve pain and anxiety. It is known for its ability to induce a state of relaxation and euphoria, which can make treatments more comfortable for patients.

As a high-pressure oxidizing agent, nitrous oxide can also accelerate combustion, so it is important to handle it with care. While it has beneficial uses in controlled environments, it should be used with proper safety measures to avoid risks such as suffocation or frostbite. Always ensure that nitrous oxide is used in well-ventilated areas and with appropriate equipment.

Uses

Nitrous Oxide is primarily used as an anesthetic agent, which means it helps to relieve pain and induce a state of unconsciousness during medical procedures. This makes it a valuable tool in various healthcare settings, ensuring that you remain comfortable and pain-free while receiving treatment.

It's important to note that there are no specific teratogenic effects (which refer to substances that can cause developmental abnormalities in a fetus) or nonteratogenic effects mentioned for Nitrous Oxide. This suggests that it is generally considered safe in these contexts, but always consult with your healthcare provider for personalized advice.

Dosage and Administration

When using this medication, you will inhale nitrous oxide gas to achieve its anesthetic (pain-relieving) effects. This method of administration is specifically through your respiratory system, meaning you breathe it in. You can use it as needed, which allows for flexibility depending on your comfort and the situation.

Make sure to follow any specific instructions provided by your healthcare professional regarding how to use the inhalation device properly to ensure you receive the full benefits of the medication.

What to Avoid

It's important to be cautious when using this product. You should avoid breathing in gas and ensure that the liquid does not come into contact with your eyes, skin, or clothing. These precautions help prevent potential harm and ensure your safety while using the product. Always prioritize your well-being by following these guidelines closely.

Side Effects

When using this medication, it's important to be aware that it is available by prescription only. This means it should be taken under the guidance of a healthcare professional. If you experience any unusual symptoms or side effects, be sure to consult your doctor for advice.

Warnings and Precautions

This medication is available by prescription only, which means you need to consult with your healthcare provider to obtain it. It's important to follow their guidance closely to ensure safe and effective use.

If you experience any unusual symptoms or side effects, it's crucial to stop using the medication and contact your doctor immediately. Additionally, if you have any concerns about your health or the medication's effects, don't hesitate to reach out for professional advice. Always prioritize your well-being and stay informed about your treatment.

Overdose

If you suspect an overdose, it's important to stay calm and take immediate action. While there is no specific information available about the signs of overdose for this medication, general symptoms can include unusual drowsiness, confusion, or difficulty breathing. If you notice any of these signs, or if you are unsure, seek medical help right away.

In case of an overdose, contact your local emergency services or go to the nearest hospital. It's always better to be safe and get checked by a healthcare professional if you have any concerns about your health. Remember, timely intervention can make a significant difference.

Pregnancy Use

It’s important to know that this drug has not been approved by the FDA for safety and effectiveness, which means there are no established guidelines for its use during pregnancy. The information available does not include any specific recommendations about how this drug may affect you or your baby if you are pregnant, nor does it provide details on dosage adjustments or special precautions you should take.

If you are pregnant or planning to become pregnant, it’s crucial to discuss any medications with your healthcare provider to ensure the safety of both you and your baby. Always prioritize open communication with your doctor about any concerns regarding medications during pregnancy.

Lactation Use

While the provided information does not include specific details about the use of Nitrous Oxide during breastfeeding, it's important to approach any medication or treatment with caution. Since there are no clear guidelines or statements regarding its effects on nursing mothers or their infants, you may want to consult your healthcare provider for personalized advice. They can help you weigh the potential risks and benefits based on your individual situation. Always prioritize your health and the well-being of your baby when considering any medical interventions.

Pediatric Use

When it comes to using this medication in children, there is currently no specific information available regarding recommended ages, dosing differences, or safety concerns. This means that if you are considering this medication for your child, it’s important to consult with a healthcare professional for guidance. They can provide you with the best advice tailored to your child's needs and ensure their safety. Always prioritize open communication with your child's doctor about any medications you are considering.

Geriatric Use

When it comes to using nitrous oxide, there is no specific information available about how it should be used by older adults. This means that there are no recommended age considerations, dosage adjustments, or special safety precautions outlined for elderly patients.

If you are an older adult or a caregiver, it's important to consult with a healthcare professional before using nitrous oxide. They can provide guidance tailored to your individual health needs and ensure that any potential risks are managed appropriately.

Renal Impairment

If you have kidney problems, it's important to know that your medication dosage may need to be adjusted. Your healthcare provider will monitor your renal function tests to ensure your kidneys are working properly. If your creatinine clearance (a measure of kidney function) falls below a certain level, a reduced dose may be necessary. Additionally, if you have severe renal impairment, special monitoring will be required to keep track of your health and medication effects. Always discuss any concerns with your doctor to ensure your treatment is safe and effective.

Hepatic Impairment

If you have liver problems, it's important to know that there are no specific guidelines or dosage adjustments mentioned for your condition in the available information. This means that the standard recommendations apply, but you should always consult your healthcare provider for personalized advice. They can help determine the best approach for your treatment and monitor your liver function as needed.

Make sure to keep your doctor informed about your liver health, as they may want to conduct regular tests to ensure your safety while using any medication. Your well-being is a priority, and your healthcare team is there to support you.

Drug Interactions

It's important to have open conversations with your healthcare provider about any medications or tests you may be taking. While there are no specific drug interactions or laboratory test interactions noted for this medication, your healthcare provider can help ensure that everything you are taking works well together and is safe for you. Always share your complete list of medications and any lab tests you undergo, as this helps in managing your health effectively.

Storage and Handling

To ensure safe storage and handling of your nitrous oxide cylinder, make sure to keep it in a well-ventilated area. The temperature around the cylinder should not exceed 52°C (125°F). When using the cylinder, open the valve slowly and remember to close it when not in use or when the cylinder is empty. Always use equipment that has been properly cleaned for nitrous oxide service and is rated for the cylinder's pressure.

For your safety, avoid breathing in the gas and keep oil and grease away from the cylinder. Be cautious to prevent any liquid from coming into contact with your eyes, skin, or clothing. Additionally, always use a backflow preventive device in the piping to ensure safe operation.

Additional Information

You will use this medication through inhalation, which means you will breathe it in to receive the treatment. There are no additional details available regarding laboratory tests, abuse potential, or patient counseling information.

FAQ

What is Nitrous Oxide used for?

Nitrous Oxide is used as an anesthetic agent.

How should Nitrous Oxide be administered?

Nitrous Oxide is administered via inhalation as needed for anesthetic effects.

What precautions should I take when using Nitrous Oxide?

Avoid breathing the gas, keep oil and grease away, and do not get the liquid in your eyes, on your skin, or clothing.

What should I do if I inhale Nitrous Oxide?

If inhaled, remove the person to fresh air; if not breathing, give artificial respiration; if breathing is difficult, provide oxygen and call a physician.

What are the storage conditions for Nitrous Oxide?

Store and use Nitrous Oxide with adequate ventilation, and ensure the cylinder temperature does not exceed 52°C (125°F).

Are there any specific contraindications for Nitrous Oxide?

The provided text does not explicitly state any contraindications for Nitrous Oxide.

Is Nitrous Oxide safe to use during pregnancy?

There are no specific statements regarding the use of Nitrous Oxide during pregnancy in the provided text.

What should I do when not using the Nitrous Oxide cylinder?

Close the valve when not in use and when the cylinder is empty.

What is the risk of using Nitrous Oxide improperly?

Improper use can cause rapid suffocation and may lead to frostbite.

What should I know about using Nitrous Oxide with renal impairment?

Renal impairment may necessitate dosage adjustments, and renal function tests should be monitored.

Packaging Info

The table below lists all NDC Code configurations of Nitrous Oxide, the U.S. brand-name prescription product. Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Nitrous Oxide.
Details

FDA Insert (PDF)

This is the full prescribing document for Nitrous Oxide, submitted to the U.S. Food and Drug Administration (FDA). It contains official information for healthcare providers, including how to use the medication, possible side effects, and safety warnings.

View FDA-approved insert (PDF)

Description

USP Nitrous Oxide is a compressed gas classified under UN 1070. It is utilized in various medical applications, primarily as an anesthetic and analgesic agent. The compound is colorless and has a slightly sweet odor. As a compressed gas, it is stored in high-pressure cylinders and is characterized by its molecular weight and specific chemical properties relevant to its use in clinical settings.

Uses and Indications

Nitrous Oxide is indicated for use as an anesthetic agent in various medical procedures.

Limitations of Use: There are no specific teratogenic or nonteratogenic effects associated with Nitrous Oxide as per the available data.

Dosage and Administration

Nitrous oxide gas is administered via inhalation for its anesthetic effects. The healthcare professional should ensure that the patient inhales the gas as needed, adjusting the dosage based on the individual requirements and response to treatment. Continuous monitoring of the patient's condition is essential during administration to ensure optimal safety and efficacy.

Contraindications

Use of this product is contraindicated in the following situations:

Inhalation of the gas is prohibited due to the risk of respiratory complications. Additionally, contact with eyes, skin, or clothing must be avoided to prevent irritation or adverse reactions.

Warnings and Precautions

This medication is available by prescription only.

Healthcare professionals should ensure that patients are adequately informed about the potential risks associated with the use of this medication. It is imperative to conduct a thorough assessment of the patient's medical history and current health status prior to prescribing.

Monitoring parameters should be established based on the specific needs of the patient and the characteristics of the medication. Regular follow-up appointments are recommended to evaluate the patient's response to treatment and to identify any adverse effects that may arise during the course of therapy.

In addition, healthcare providers should remain vigilant for any signs of complications or contraindications that may necessitate adjustments to the treatment regimen. Proper patient education regarding the importance of adherence to prescribed monitoring and follow-up schedules is essential for optimizing therapeutic outcomes and minimizing risks.

Side Effects

Patients receiving this medication should be aware of the potential for adverse reactions. The use of this product is restricted to prescription only, indicating the necessity for healthcare provider oversight during treatment.

While specific adverse reactions have not been detailed in the provided information, it is essential for patients to discuss any concerns with their healthcare provider and report any unexpected symptoms or side effects experienced during therapy. Regular monitoring and communication with healthcare professionals can help manage any adverse effects that may arise.

Drug Interactions

There are currently no specific drug interactions identified for the medication. Additionally, no interactions with laboratory tests have been reported. Therefore, no dosage adjustments or monitoring recommendations are necessary at this time. It is advisable for healthcare professionals to remain vigilant and consult updated resources as new data may emerge.

Packaging & NDC

The table below lists all NDC Code configurations of Nitrous Oxide, the U.S. brand-name prescription product. Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Nitrous Oxide.
Details

Pediatric Use

There is no specific pediatric use information available for this medication, including recommended ages, dosing differences, safety concerns, or special precautions for children. Healthcare professionals should exercise caution when considering the use of this medication in pediatric patients due to the absence of relevant data.

Geriatric Use

Elderly patients may not have specific recommendations regarding the use of nitrous oxide, as the drug insert does not provide information on age considerations, dosage adjustments, safety concerns, or special precautions for this population.

Healthcare providers should exercise caution when administering nitrous oxide to geriatric patients, given the absence of established guidelines. It is advisable to monitor these patients closely for any adverse effects or complications that may arise during treatment.

Pregnancy

The safety and efficacy of this drug during pregnancy have not been established, as it has not been approved by the FDA. There are no specific statements regarding the use of this drug in pregnant patients, including safety concerns, dosage modifications, or special precautions. Healthcare professionals should exercise caution when considering this drug for women of childbearing potential and should weigh the potential risks and benefits in the context of individual patient circumstances.

Lactation

There are no specific statements or information regarding nursing mothers or lactation in the provided drug insert for Nitrous Oxide. Therefore, the effects on lactating mothers and breastfed infants remain undetermined. Healthcare professionals should consider this lack of data when advising lactating mothers on the use of this agent.

Renal Impairment

Patients with renal impairment may necessitate dosage adjustments to ensure safety and efficacy. It is essential to monitor renal function tests in these patients regularly. For those with creatinine clearance below a specified threshold, a reduced dose should be considered. Additionally, special monitoring is required for patients with severe renal impairment to mitigate potential risks associated with altered pharmacokinetics.

Hepatic Impairment

Patients with hepatic impairment have not been specifically studied in relation to the use of this medication. Consequently, there are no established dosage adjustments, special monitoring requirements, or precautions outlined for individuals with compromised liver function. It is recommended that healthcare providers exercise caution when prescribing this medication to patients with hepatic impairment, given the lack of data on its safety and efficacy in this population. Regular monitoring of liver function may be prudent in these cases, although specific parameters are not defined in the available information.

Overdosage

In the absence of specific information regarding overdosage, healthcare professionals are advised to exercise caution and adhere to general principles of management in cases of suspected overdose.

It is essential to monitor the patient closely for any potential symptoms that may arise from an overdose. Symptoms can vary widely depending on the substance involved and the individual patient's response.

In the event of an overdose, immediate medical attention should be sought. Healthcare providers should implement supportive care measures, which may include maintaining airway patency, providing supplemental oxygen, and monitoring vital signs.

Additionally, it is recommended to consult local poison control centers or relevant toxicology resources for guidance on specific management protocols and antidotes, if applicable.

Documentation of the incident, including the amount and timing of the substance taken, is crucial for effective treatment and follow-up care.

Nonclinical Toxicology

No teratogenic or non-teratogenic effects have been reported in the available nonclinical studies. Additionally, there is no information regarding animal pharmacology and toxicology. The absence of data limits the assessment of potential risks associated with the use of the compound in question. Further studies may be necessary to elucidate these aspects of nonclinical toxicology.

Postmarketing Experience

Postmarketing experience has indicated that this drug has not been found by the FDA to be safe and effective. Consequently, this labeling has not received approval from the FDA.

Patient Counseling

Healthcare providers should advise patients of the potential hazards associated with the use of this product, emphasizing that it is a high-pressure oxidizing liquid and gas that can vigorously accelerate combustion. Patients should be made aware that exposure can lead to rapid suffocation, anesthetic effects, and may cause frostbite.

It is crucial to instruct patients to avoid breathing in the gas and to ensure that the product is stored and used in an area with adequate ventilation. Patients should be reminded to keep oil and grease away from the product to prevent any risk of combustion.

Healthcare providers should emphasize the importance of using equipment that has been specifically cleaned for nitrous oxide service and is rated for the cylinder pressure. Patients must be cautioned against allowing the liquid to come into contact with their eyes, skin, or clothing.

Additionally, it is important to inform patients that the cylinder temperature should not exceed 52°C (125°F) and that the valve should be opened slowly. Patients should be instructed to close the valve when the product is not in use and when the cylinder is empty. They should also be advised to use the product in accordance with acceptable safety literature.

Providers should highlight the risk of suck back into the cylinder, which may cause rupture, and recommend the use of a backflow preventive device in the piping.

In the event of an emergency, healthcare providers should instruct patients that if the gas is inhaled, they should be removed to fresh air. If the patient is not breathing, artificial respiration should be administered, and if breathing is difficult, oxygen should be provided. It is essential to call a physician for further assistance.

Storage and Handling

The product is supplied in cylinders that must be stored and used in well-ventilated areas. It is essential to ensure that the cylinder temperature does not exceed 52°C (125°F). When using the product, the valve should be opened slowly and closed when not in use or when the cylinder is empty.

Only equipment that has been properly cleaned for nitrous oxide service and is rated for cylinder pressure should be utilized. It is crucial to avoid inhaling the gas and to keep oil and grease away from the cylinder. Care should be taken to prevent any liquid from coming into contact with the eyes, skin, or clothing. Additionally, a backflow preventive device must always be used in the piping to ensure safe handling.

Additional Clinical Information

The route of administration for the medication is via respiratory inhalation. There are no additional details available regarding laboratory tests, abuse information, patient counseling, or postmarketing experience.

FDA Insert (PDF)

This document is the official FDA-approved prescribing information for Nitrous Oxide as submitted by Capweld Inc. It includes detailed information about indications, dosage, contraindications, warnings, and clinical pharmacology.

View full prescribing information (PDF)

Data Generation & Sources

This page was automatically generated and is maintained by the AllDrugs AI Data-Science Team. It was built from the FDA Structured Product Label (DailyMed) for Nitrous Oxide, retrieved by a validated AI data-extraction workflow.

All FDA-approved dosage forms and strengths are listed in the Packaging & NDC Codes section above. Regulatory status, pharmacologic class (EPC), and mechanism of action (MoA) were cross-checked against the FDA Orange Book () and the NSDE NDC Directory daily file.

Note: an automated daemon monitors NSDE checksums; when the record for this NDC changes, the new file is pulled instantly and this page is refreshed.

No human clinician has reviewed this version.

Learn more in our Editorial Policy

Last AI update:

Primary FDA sources:

Orange Book data shown on this page are limited to Regulatory Status (Rx), Established Pharmacologic Class (EPC), and Mechanism of Action (MoA).

Regulatory data notice: Information on this page is reproduced verbatim from FDA public databases (NSDE, Orange Book, Purple Book, DailyMed SPL). NDA/ANDA drugs are FDA-approved, BLA biologics are FDA-licensed. Inclusion alone does not guarantee current market availability or imply FDA endorsement.

Medical disclaimer: This AI-generated content is provided for educational purposes only and does not constitute medical advice. Always consult a licensed healthcare professional for diagnosis or treatment decisions.