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Proactiv Plus Complexion Perfecting Hydrator

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Active ingredient
Salicylic Acid 0.5 g/100 mL
Other brand names
Dosage form
Cream
Route
Topical
Prescription status
OTC (over the counter)
Marketed in the U.S.
Since 2013
Label revision date
January 7, 2026
Active ingredient
Salicylic Acid 0.5 g/100 mL
Other brand names
Dosage form
Cream
Route
Topical
Prescription status
OTC (over the counter)
CSA schedule
Not a scheduled drug
Marketed in the U.S.
Since 2013
Label revision date
January 7, 2026
Manufacturer
Alchemee, LLC
Registration number
M006
NDC root
11410-023

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Drug Overview

Proactiv+ is a skincare product designed to help manage acne. It is known as a Complexion Perfecting Hydrator and contains salicylic acid, which is a common ingredient used in acne treatments. Salicylic acid works by penetrating the skin to help clear clogged pores and reduce inflammation, making it effective for treating acne.

This product comes in a 3 FL. OZ. (89 mL) bottle and is specifically formulated to improve your skin's appearance by addressing acne-related issues. If you're looking for a solution to help manage your acne, Proactiv+ may be a suitable option to consider.

Uses

If you're dealing with acne, this medication can help manage your condition effectively. It is specifically designed to treat acne, helping to reduce breakouts and improve the overall appearance of your skin.

You can feel reassured knowing that there are no teratogenic effects (which means it doesn't cause birth defects) associated with this medication. Additionally, there are no nonteratogenic effects (which refer to other harmful effects that don't involve birth defects) mentioned, making it a safe option for those looking to manage their acne.

Dosage and Administration

To use this product effectively, start by applying it sparingly to one or two small areas of your skin for the first three days. This is important to test how your skin reacts to the product. Make sure to clean the skin thoroughly before each application. If you don’t experience any discomfort during this testing period, you can proceed to cover the entire affected area with a thin layer of the product.

Initially, apply it once a day to prevent excessive drying of your skin. If your skin tolerates it well, you can gradually increase the frequency to two or three times a day, as needed or as directed by your doctor. However, if you notice any bothersome dryness or peeling, it’s best to reduce your application to once a day or even every other day. This way, you can find the right balance for your skin while still treating the affected areas.

What to Avoid

It's important to take care when using this medication. You should avoid contact with your eyes; if this happens, make sure to rinse your eyes thoroughly with water to prevent irritation. There are no specific contraindications, controlled substance classifications, or noted risks of abuse, misuse, or dependence associated with this medication. Always follow these guidelines to ensure your safety and well-being.

Side Effects

For this medication, it is important to note that it is intended for external use only. There are no specific side effects or adverse reactions reported, which suggests that it may be well-tolerated. However, always be mindful of how your body responds and consult a healthcare professional if you have any concerns.

Warnings and Precautions

This medication is for external use only, so please do not apply it to any areas other than your skin. Be cautious if you are using other topical acne treatments at the same time, as this can increase the risk of skin irritation and dryness. If you experience irritation, it’s best to stop using all but one of the treatments. Also, make sure to avoid getting the medication in your eyes; if this happens, rinse your eyes thoroughly with water.

If you accidentally swallow this medication, seek medical help immediately or contact a Poison Control Center. While there are no specific instructions to stop taking this medication and call your doctor, always consult your healthcare provider if you have any concerns or experience unusual symptoms.

Overdose

It appears that there is no specific information available regarding overdosage for this medication. However, it's important to be aware of the general signs of an overdose, which can include symptoms like extreme drowsiness, confusion, or difficulty breathing. If you suspect an overdose, it is crucial to seek immediate medical attention.

In case of an emergency, call your local emergency services or go to the nearest hospital. Always keep your medications in a safe place and follow the prescribed dosage to prevent any potential risks. If you have any concerns or questions about your medication, don’t hesitate to reach out to your healthcare provider for guidance.

Pregnancy Use

If you are pregnant or planning to become pregnant, it's important to know that the safety of this product has not been established. Salicylic acid, a key ingredient in this product, is not recommended during pregnancy due to potential risks to your developing baby, including the possibility of teratogenic effects (which means it could cause birth defects).

You should avoid using this product unless your healthcare provider specifically advises you to do so. Always consult with a healthcare professional before using any medication or treatment during pregnancy to ensure the safety of both you and your baby.

Lactation Use

If you are breastfeeding, you can feel reassured that there are no specific warnings or recommendations regarding the use of Proactiv+ Complexion Perfecting Hydrator for nursing mothers. The information available does not indicate any concerns about its use during lactation or any potential for the product to be passed into breast milk.

As always, if you have any questions or concerns about using skincare products while breastfeeding, it's a good idea to consult with your healthcare provider for personalized advice.

Pediatric Use

It's important to keep this medication out of reach of children to prevent accidental ingestion. If your child swallows any of it, seek medical help immediately or contact a Poison Control Center for guidance. Taking these precautions can help ensure your child's safety.

Geriatric Use

While there is no specific information about the use of Proactiv Plus Complexion Perfecting Hydrator in older adults, it’s always wise to approach new products with caution. Since the drug insert does not mention any dosage adjustments or safety concerns for elderly patients, you should consider consulting with a healthcare professional before starting this product. This is especially important if you have any underlying health conditions or are taking other medications. Your healthcare provider can help ensure that this product is suitable for your individual needs.

Renal Impairment

If you have kidney problems, it's important to know that the information provided does not include specific guidelines for dosage adjustments, special monitoring, or safety considerations related to renal impairment (kidney issues). This means that there are no tailored recommendations for how your treatment may need to change based on your kidney function.

Always consult your healthcare provider for personalized advice and to ensure that your treatment plan is safe and effective for your specific situation. They can help monitor your kidney health and make any necessary adjustments to your medications.

Hepatic Impairment

If you have liver problems, it's important to know that the information provided does not include specific guidelines for dosage adjustments, special monitoring, or precautions related to your condition. This means that there are no tailored recommendations for how the medication may affect you differently due to your liver health.

Always consult your healthcare provider for personalized advice and to ensure that any treatment plan is safe and effective for your specific situation. They can help determine the best approach based on your liver function and overall health.

Drug Interactions

It's important to have open conversations with your healthcare provider about any medications or tests you may be taking. While there are no specific drug interactions or laboratory test interactions noted for this medication, your healthcare provider can help ensure that everything you are taking works well together and is safe for you. Always share your complete list of medications and any recent lab tests to avoid any potential issues. Your health and safety should always come first.

Storage and Handling

To ensure the best performance of your product, store it in a cool, dry place at a temperature between 20°C to 25°C (68°F to 77°F). It’s acceptable for the temperature to occasionally range from 15°C to 30°C (59°F to 86°F), but try to keep it within the recommended limits. Make sure to protect the product from light and always keep the container tightly closed when not in use.

Once you open the container, remember to discard any remaining product to maintain safety and effectiveness. Following these guidelines will help you use the product safely and effectively.

Additional Information

You will be using this medication topically, which means it is applied directly to the skin. If you experience any irritation, it's important to use only one topical acne medication at a time to avoid worsening the issue. Be careful to avoid contact with your eyes; if this happens, rinse your eyes thoroughly with water. If you notice bothersome dryness or peeling of your skin, consider reducing the application to once a day or every other day.

FAQ

What is Proactiv+?

Proactiv+ is a Complexion Perfecting Hydrator indicated for the management of acne.

What is the active ingredient in Proactiv+?

Proactiv+ contains salicylic acid, which is used for acne treatment.

How should I apply Proactiv+?

Apply the product sparingly to one or two small affected areas during the first 3 days for sensitivity testing. If no discomfort occurs, cover the entire affected area with a thin layer one to three times daily.

What should I do if I experience dryness or peeling?

If bothersome dryness or peeling occurs, reduce application to once a day or every other day.

Are there any contraindications for using Proactiv+?

There are no contraindications listed, but avoid contact with eyes. If contact occurs, rinse eyes thoroughly with water.

Is Proactiv+ safe to use during pregnancy?

The safety of Proactiv+ during pregnancy has not been established, and salicylic acid is contraindicated due to potential risks to the fetus.

What should I do if I swallow Proactiv+?

If swallowed, get medical help or contact a Poison Control Center right away.

How should I store Proactiv+?

Store Proactiv+ at 20°C to 25°C (68°F to 77°F) and protect it from light. Keep the container tightly closed and discard after opening.

Packaging Info

Below are the non-prescription pack sizes of Proactiv Plus Complexion Perfecting Hydrator (salicylic acid). Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Proactiv Plus Complexion Perfecting Hydrator.
Details

Drug Information (PDF)

This file contains official product information for Proactiv Plus Complexion Perfecting Hydrator, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Description

No description information is available for the specified drug.

Uses and Indications

This drug is indicated for the management of acne.

There are no teratogenic effects associated with this medication. Additionally, no nonteratogenic effects have been reported.

Dosage and Administration

The product should be applied sparingly to one or two small affected areas during the initial three days for sensitivity testing. Prior to application, the skin must be cleaned thoroughly. Following the sensitivity testing phase, the entire affected area should be covered with a thin layer of the product one to three times daily.

It is recommended to start with one application per day to minimize the risk of excessive drying of the skin. Based on the patient's response, the frequency of application may be gradually increased to two or three times daily, as needed or as directed by a healthcare professional.

In cases where bothersome dryness or peeling occurs, the application frequency should be reduced to once daily or every other day to alleviate these symptoms.

Contraindications

Use is contraindicated in individuals with a history of eye contact. In the event of contact with the eyes, it is imperative to rinse thoroughly with water. No other contraindications have been identified.

Warnings and Precautions

For external use only.

Skin irritation and dryness may be exacerbated when used concurrently with other topical acne medications. It is advised that only one topical acne treatment be utilized at a time to minimize the risk of irritation. Healthcare professionals should counsel patients to avoid contact with the eyes; in the event of accidental contact, it is imperative to rinse the eyes thoroughly with water.

In cases of ingestion, immediate medical assistance should be sought, or the Poison Control Center should be contacted without delay.

Patients are advised to discontinue use and consult their healthcare provider if they experience any adverse effects, although specific instructions for cessation were not provided in the available information.

Side Effects

For external use only. No specific side effects or adverse reactions have been reported in clinical trials or postmarketing experiences. Patients should be advised to use the product as directed and to consult a healthcare professional if any unexpected reactions occur.

Drug Interactions

There are currently no documented drug interactions associated with this medication. Additionally, there is no information available regarding interactions with laboratory tests. As such, no specific recommendations for dosage adjustments or monitoring are warranted at this time.

Packaging & NDC

Below are the non-prescription pack sizes of Proactiv Plus Complexion Perfecting Hydrator (salicylic acid). Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Proactiv Plus Complexion Perfecting Hydrator.
Details

Pediatric Use

Pediatric patients should be advised to keep this medication out of reach of children. In the event of accidental ingestion, immediate medical assistance should be sought, or contact with a Poison Control Center is recommended.

Geriatric Use

There is no specific information regarding the use of Proactiv Plus Complexion Perfecting Hydrator in geriatric patients. Consequently, there are no established dosage adjustments, safety concerns, or special precautions that are specifically indicated for elderly patients. Healthcare providers should exercise clinical judgment when considering the use of this product in the geriatric population, as individual patient factors may influence treatment outcomes. Monitoring for any adverse effects is advisable, given the lack of targeted data for this demographic.

Pregnancy

The safety of this product during pregnancy has not been established. Salicylic acid is contraindicated in pregnancy due to potential risks to the fetus, including the risk of teratogenic effects associated with its use. Pregnant women should avoid the use of this product unless directed by a healthcare provider. It is recommended that women of childbearing potential consult a healthcare professional before using this product if they are pregnant or planning to become pregnant.

Lactation

There are no specific warnings or recommendations regarding the use of Proactiv+ Complexion Perfecting Hydrator in lactating mothers. Additionally, there are no considerations or precautions related to lactation or the potential for excretion in breast milk mentioned in the prescribing information.

Renal Impairment

Patients with renal impairment may not have specific dosage adjustments, special monitoring, or safety considerations outlined in the prescribing information. Therefore, healthcare professionals should exercise caution when prescribing to patients with reduced kidney function, as the lack of detailed guidance necessitates careful clinical judgment and individualized patient assessment.

Hepatic Impairment

Patients with hepatic impairment have not been specifically studied in relation to the use of this medication. Consequently, there are no established dosage adjustments, special monitoring requirements, or precautions outlined for individuals with compromised liver function. It is recommended that healthcare providers exercise caution when prescribing this medication to patients with hepatic impairment, given the lack of data on its safety and efficacy in this population. Regular monitoring of liver function may be prudent in these cases, although specific parameters are not defined in the available information.

Overdosage

There is currently no specific information available regarding overdosage for this medication. Healthcare professionals are advised to monitor patients closely for any signs of adverse effects or symptoms that may arise from excessive dosing.

In the event of suspected overdosage, it is recommended that healthcare providers initiate supportive care and symptomatic treatment as necessary. Patients should be evaluated for potential complications, and appropriate interventions should be implemented based on the clinical presentation.

For further guidance, healthcare professionals should refer to established protocols and consult relevant toxicology resources.

Nonclinical Toxicology

No teratogenic or non-teratogenic effects have been reported in the available nonclinical studies. Additionally, there is no information regarding animal pharmacology and toxicology. The absence of data limits the assessment of potential risks associated with the compound in these areas.

Postmarketing Experience

No postmarketing experience details are available in the insert text.

Patient Counseling

Healthcare providers should advise patients to seek immediate medical assistance or contact a Poison Control Center if the medication is swallowed.

It is important to inform patients that the use of this medication in conjunction with other topical acne treatments may increase the likelihood of skin irritation and dryness. Therefore, if patients experience irritation, they should be instructed to use only one topical acne medication at a time to minimize adverse effects.

Patients should also be cautioned to avoid contact with their eyes. In the event of accidental eye contact, they should rinse their eyes thoroughly with water to alleviate any potential discomfort.

Storage and Handling

The product is supplied in a container that must be kept tightly closed to maintain integrity. It should be stored at a temperature range of 20°C to 25°C (68°F to 77°F), with permissible excursions between 15°C to 30°C (59°F to 86°F). It is essential to protect the product from light to prevent degradation. Once opened, the product should be discarded to ensure safety and efficacy.

Additional Clinical Information

The route of administration for the medication is topical. Clinicians should advise patients to use only one topical acne medication at a time to minimize the risk of irritation. Patients are also cautioned to avoid contact with the eyes; in the event of contact, they should rinse their eyes thoroughly with water. If patients experience bothersome dryness or peeling, they should reduce the frequency of application to once a day or every other day.

Drug Information (PDF)

This file contains official product information for Proactiv Plus Complexion Perfecting Hydrator, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Data Generation & Sources

This page was automatically generated and is maintained by the AllDrugs AI Data-Science Team. It was built from the FDA Structured Product Label (DailyMed) for Proactiv Plus Complexion Perfecting Hydrator, retrieved by a validated AI data-extraction workflow.

All FDA-listed dosage forms and strengths are shown in the Packaging & NDC Codes section above. Regulatory status appears in the Summary Information panel above and was verified in the FDA National Drug Code directory and the NSDE NDC Directory daily file.

Note: an automated daemon monitors NSDE checksums; when the record for this NDC changes, the new file is pulled instantly and this page is refreshed.

No human clinician has reviewed this version.

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Primary FDA sources:

Orange Book data shown on this page are limited to Regulatory Status (Rx), Established Pharmacologic Class (EPC), and Mechanism of Action (MoA).

Regulatory data notice: Information on this page is reproduced verbatim from FDA public databases (NSDE, Orange Book, Purple Book, DailyMed SPL). NDA/ANDA drugs are FDA-approved, BLA biologics are FDA-licensed. Inclusion alone does not guarantee current market availability or imply FDA endorsement.

Medical disclaimer: This AI-generated content is provided for educational purposes only and does not constitute medical advice. Always consult a licensed healthcare professional for diagnosis or treatment decisions.