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Up and up Daytime Childrens Multi Symptom Cold

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Active ingredients
  • Guaifenesin 100 mg/5 mL
  • Dextromethorphan Hydrobromide 5 mg/5 mL
  • Phenylephrine Hydrochloride 2.5 mg/5 mL
Other brand names
Drug classes
Expectorant, Sigma-1 Agonist, Uncompetitive N-methyl-D-aspartate Receptor Antagonist, alpha-1 Adrenergic Agonist
Dosage form
Suspension
Route
Oral
Prescription status
OTC (over the counter)
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 2024
Label revision date
November 5, 2025
Drug Information (PDF)
Prescribing information, PDF file
Active ingredients
  • Guaifenesin 100 mg/5 mL
  • Dextromethorphan Hydrobromide 5 mg/5 mL
  • Phenylephrine Hydrochloride 2.5 mg/5 mL
Other brand names
Drug classes
Expectorant, Sigma-1 Agonist, Uncompetitive N-methyl-D-aspartate Receptor Antagonist, alpha-1 Adrenergic Agonist
Dosage form
Suspension
Route
Oral
Prescription status
OTC (over the counter)
CSA schedule
Not a scheduled drug
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 2024
Label revision date
November 5, 2025
Manufacturer
Target Corporation
Registration number
M012
NDC root
82442-694
Drug Information (PDF)
Prescribing information, PDF file
Packaging Info
Packaging & NDC Codes

If you are a healthcare professional or from the pharmaceutical industry please visit this version.

If you are a consumer or patient please visit this version.

Drug Overview

Up& UP Children's Multi Symptom Cold Relief is a medication designed to help relieve various symptoms associated with the common cold in children aged 4 to 11. It works by loosening phlegm (mucus) and thinning bronchial secretions, making coughs more productive. This product temporarily alleviates cough due to minor throat and bronchial irritation, helps reduce the impulse to cough, and provides relief from nasal congestion and a stuffy nose.

The active ingredients include dextromethorphan HBr, which acts as a cough suppressant; guaifenesin, an expectorant that helps clear mucus; and phenylephrine HCl, a nasal decongestant that reduces swelling in the nasal passages. With a pleasant berry flavor, this liquid formulation aims to make it easier for your child to breathe and sleep comfortably during cold symptoms.

Uses

This medication is designed to help you breathe easier by loosening phlegm (mucus) and thinning bronchial secretions. This action helps clear out bothersome mucus from your airways, making your coughs more productive.

You can use this medication to temporarily relieve cough caused by minor throat and bronchial irritation, which can happen with the common cold or from inhaling irritants. It also helps reduce the intensity of your cough and the urge to cough, making it easier for your child to fall asleep. Additionally, it can relieve nasal congestion and a stuffy nose associated with colds.

Dosage and Administration

When using this medication, it's important to follow the dosing instructions carefully to ensure safety and effectiveness. You should only take a maximum of 6 doses within a 24-hour period. To measure your dose accurately, use the dosing cup that comes with the medication, and avoid using it with any other products to prevent confusion.

For children aged 6 years to under 12 years, the recommended dose is 10 mL every 4 hours. If your child is between 4 and under 6 years old, the dose is 5 mL every 4 hours. However, if your child is under 4 years of age, this medication should not be used. Always consult with a doctor if you have any questions or need further guidance on dosing.

What to Avoid

It’s important to be cautious when considering this medication for your child. You should not use it if your child is currently taking a prescription monoamine oxidase inhibitor (MAOI), which are medications often prescribed for depression, certain psychiatric conditions, or Parkinson's disease. Additionally, you must wait at least two weeks after stopping an MAOI before using this product. If you're unsure whether your child's medication includes an MAOI, please consult a doctor or pharmacist.

While using this product, make sure to follow the dosage instructions carefully and do not exceed the recommended amount. Misuse or taking more than directed can lead to serious health issues, including dependence (a condition where the body becomes reliant on a substance). Always prioritize safety and seek guidance if you have any questions or concerns.

Side Effects

If you notice nervousness, dizziness, or trouble sleeping while using this medication, it's important to stop and consult your doctor. Additionally, if your symptoms do not improve within 7 days, or if you experience a cough that lasts more than a week, returns, or is accompanied by fever, rash, or a persistent headache, seek medical advice as these could indicate a more serious issue.

You should not use this medication if your child is taking a prescription monoamine oxidase inhibitor (MAOI) for conditions like depression or Parkinson's disease, or for two weeks after stopping an MAOI. Before using this medication, consult a doctor if your child has heart disease, high blood pressure, thyroid disease, diabetes, or a cough with excessive mucus, or if they have a chronic cough, such as from asthma. In case of an overdose, seek immediate medical help or contact a Poison Control Center at 1-800-222-1222.

Warnings and Precautions

You should not give this product to a child who is currently taking a prescription monoamine oxidase inhibitor (MAOI) for conditions like depression or Parkinson's disease, or for two weeks after stopping such medication. If you're unsure whether your child's prescription includes an MAOI, please consult a doctor or pharmacist before use.

Before using this product, it's important to check with a doctor if your child has any of the following conditions: heart disease, high blood pressure, thyroid disease, diabetes, a cough with excessive mucus, or a chronic cough like asthma. Always follow the dosing instructions carefully and do not exceed the recommended amount.

If your child experiences nervousness, dizziness, or trouble sleeping, or if their symptoms do not improve within seven days, stop using the product and contact a doctor. Additionally, if a cough lasts more than seven days, returns, or is accompanied by fever, rash, or a persistent headache, seek medical advice as these may indicate a more serious issue. Keep this product out of reach of children, and in case of an overdose, get medical help immediately or contact a Poison Control Center at 1-800-222-1222.

Overdose

If you suspect an overdose, it’s crucial to seek medical help immediately. You can contact a Poison Control Center at 1-800-222-1222 for guidance. Signs of an overdose can vary, but they may include unusual drowsiness, confusion, or difficulty breathing.

Always take overdoses seriously. If you notice any of these symptoms or if you are unsure, don’t hesitate to reach out for help right away. Your safety is the top priority.

Pregnancy Use

If you are pregnant or planning to become pregnant, it's important to know that the safety of this product during pregnancy has not been established. There may be potential risks to your fetus, but specific studies or data are not available to clarify these risks. Therefore, it is crucial to consult your doctor before using this product.

While there are no specific dosage modifications mentioned for pregnant individuals, seeking medical advice is strongly recommended to ensure your safety and that of your baby. Always prioritize open communication with your healthcare provider regarding any medications or products you consider using during pregnancy.

Lactation Use

If you are breastfeeding, you can feel reassured that there are no specific warnings or recommendations regarding the use of this product while nursing. Currently, there is also no information available about whether this product is excreted in breast milk or any potential risks to your infant.

As always, it's a good idea to consult with your healthcare provider if you have any concerns or questions about using this product while breastfeeding. Your health and the health of your baby are important, and your provider can help you make informed decisions.

Pediatric Use

It's important to be cautious when giving this medication to children. You should not use it if your child is currently taking a prescription monoamine oxidase inhibitor (MAOI) or has stopped taking one within the last two weeks. Before using this medication, consult your doctor if your child has any of the following conditions: heart disease, high blood pressure, thyroid disease, diabetes, a cough with excessive mucus, or a persistent cough, such as that associated with asthma.

For dosing, children aged 6 to under 12 years can take 10 mL every 4 hours, while those aged 4 to under 6 years should take 5 mL every 4 hours. It is not recommended for children under 4 years of age. Always follow these guidelines to ensure your child's safety.

Geriatric Use

While there is no specific information about the use of this medication in older adults, it’s important to approach any new treatment with caution. Since the insert mainly discusses pediatric use, you should consult your healthcare provider for personalized advice. They can help determine if this medication is appropriate for you or your loved one, considering any unique health needs or potential risks.

Always discuss any existing health conditions or medications with your doctor, as they can provide guidance on safety and effectiveness tailored to older adults. Your healthcare provider may also suggest monitoring for any side effects or changes in health while using this medication.

Renal Impairment

If you have kidney problems, it's important to know that the information provided does not include specific guidelines for dosage adjustments, special monitoring, or safety considerations related to renal impairment (kidney issues). This means that there are no tailored recommendations for how your treatment may need to change based on your kidney function.

Always consult your healthcare provider for personalized advice and to ensure that your treatment plan is safe and effective for your specific situation. They can help monitor your kidney health and make any necessary adjustments to your medications.

Hepatic Impairment

If you have liver problems, it's important to know that the drug insert does not provide specific information about dosage adjustments, special monitoring, or precautions for your condition. This means that there are no tailored guidelines for how this medication may affect you if you have hepatic impairment (liver issues).

Before starting any new medication, including this one, you should discuss your liver health with your healthcare provider. They can help determine the best approach for your treatment and ensure your safety.

Drug Interactions

It's important to have open conversations with your healthcare provider about any medications or tests you may be taking. While there are no specific drug interactions or laboratory test interactions noted for this medication, your healthcare provider can help ensure that everything you are taking works well together and is safe for you.

Always feel free to ask questions and share your complete list of medications and any lab tests you may be undergoing. This way, you can avoid any potential issues and receive the best care possible.

Storage and Handling

To ensure the best performance of your product, store it at room temperature. It's important not to refrigerate it, as this can affect its effectiveness. When using the product, make sure to utilize the dosing cup provided, as it is designed to help you measure the correct amount safely and accurately.

Always handle the product with care, keeping it in a clean environment to maintain its quality. Following these simple guidelines will help you use the product safely and effectively.

Additional Information

You will take this medication orally. There are no additional details available regarding laboratory tests, abuse potential, patient counseling, or postmarketing experiences. If you have any questions or concerns about your treatment, be sure to discuss them with your healthcare provider.

FAQ

What is Up& UP Children's Multi Symptom Cold Relief used for?

It helps loosen phlegm and thin bronchial secretions, temporarily relieving cough, nasal congestion, and stuffy nose due to colds.

What are the active ingredients in this product?

The active ingredients are Dextromethorphan HBr (5 mg), Guaifenesin (100 mg), and Phenylephrine HCl (2.5 mg).

What is the recommended dosage for children?

For children 6 to under 12 years, the dosage is 10 mL every 4 hours; for children 4 to under 6 years, it's 5 mL every 4 hours. Do not use in children under 4 years.

Are there any contraindications for using this product?

Do not use if the child is taking a prescription monoamine oxidase inhibitor (MAOI) or for 2 weeks after stopping an MAOI.

What should I do if my child experiences side effects?

Stop use and ask a doctor if nervousness, dizziness, or sleeplessness occur, or if symptoms do not improve within 7 days.

Is this product safe to use during pregnancy?

The safety of this product during pregnancy has not been established, so consult a doctor before use if pregnant or planning to become pregnant.

How should this product be stored?

Store at room temperature and do not refrigerate. Use the dosing cup provided for measurement.

What should I do in case of overdose?

In case of overdose, get medical help or contact a Poison Control Center immediately at 1-800-222-1222.

Packaging Info

Below are the non-prescription pack sizes of Up and up Daytime Childrens Multi Symptom Cold (dextromethorphan hydrobromide, guaifenesin, and phenylephrine hydrochloride). Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Up and up Daytime Childrens Multi Symptom Cold.
Details

Drug Information (PDF)

This file contains official product information for Up and up Daytime Childrens Multi Symptom Cold, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Description

No description information is available for the drug.

Uses and Indications

This drug is indicated for the relief of cough associated with minor throat and bronchial irritation, which may occur due to the common cold or inhaled irritants. It assists in loosening phlegm (mucus) and thinning bronchial secretions, thereby facilitating the clearance of bothersome mucus and enhancing the productivity of coughs.

Additionally, this drug temporarily alleviates the intensity of coughing and reduces the impulse to cough, which may help children achieve restful sleep. It also provides relief from nasal congestion and a stuffy nose associated with colds.

There are no teratogenic or nonteratogenic effects reported for this drug.

Dosage and Administration

The maximum recommended dosage is six doses within a 24-hour period. Dosing should be measured exclusively with the dosing cup provided, and this cup should not be used with any other products to ensure accurate dosing.

For children aged 6 years to under 12 years, the recommended dose is 10 mL every 4 hours as needed. For children aged 4 to under 6 years, the appropriate dose is 5 mL every 4 hours as needed. It is important to note that this product is not recommended for use in children under 4 years of age.

Healthcare professionals should advise caregivers to adhere strictly to these dosing guidelines or any alternative dosing instructions provided by a physician.

Contraindications

Use of this product is contraindicated in children who are currently taking a prescription monoamine oxidase inhibitor (MAOI) or within 2 weeks of discontinuing an MAOI. MAOIs are typically prescribed for depression, psychiatric or emotional conditions, or Parkinson's disease. If there is uncertainty regarding the presence of an MAOI in a child's prescription, consultation with a healthcare professional is advised prior to administration of this product. Additionally, it is essential to adhere to the recommended dosage and not exceed the directed use while utilizing this product.

Warnings and Precautions

The use of this product is contraindicated in children who are currently taking a prescription monoamine oxidase inhibitor (MAOI) or have taken an MAOI within the past two weeks. MAOIs are commonly prescribed for depression, psychiatric or emotional conditions, and Parkinson's disease. Healthcare professionals should advise caregivers to consult a doctor or pharmacist if there is uncertainty regarding the presence of an MAOI in the child's prescription medication.

Prior to administration, it is essential to consult a healthcare provider if the child has any of the following conditions: heart disease, high blood pressure, thyroid disease, diabetes, a cough associated with excessive phlegm (mucus), or a persistent or chronic cough, such as that which occurs with asthma. These conditions may necessitate special consideration or alternative treatment options.

It is imperative that the product is used strictly as directed. Exceeding the recommended dosage can lead to adverse effects.

Healthcare professionals should instruct caregivers to discontinue use and seek medical advice if the child experiences nervousness, dizziness, or sleeplessness. Additionally, if symptoms do not improve within seven days, or if they are accompanied by fever, or if a cough persists for more than seven days, recurs, or is associated with fever, rash, or a persistent headache, medical evaluation is warranted. These symptoms may indicate a more serious underlying condition.

To ensure safety, this product should be kept out of reach of children. In the event of an overdose, immediate medical assistance should be sought, or the Poison Control Center should be contacted at 1-800-222-1222.

Side Effects

Patients should be monitored for the occurrence of nervousness, dizziness, or sleeplessness, which may necessitate discontinuation of use and consultation with a healthcare provider. If symptoms do not improve within 7 days, or if they are accompanied by fever, patients should seek medical advice. Additionally, a cough that persists for more than 7 days, recurs, or occurs with fever, rash, or a persistent headache may indicate a serious underlying condition and requires medical evaluation.

The product is contraindicated in children who are currently taking a prescription monoamine oxidase inhibitor (MAOI) or have taken one within the past 2 weeks. Patients with a history of heart disease, high blood pressure, thyroid disease, diabetes, or those experiencing a cough associated with excessive phlegm or chronic conditions such as asthma should consult a healthcare professional prior to use.

In the event of an overdose, immediate medical assistance should be sought, or the Poison Control Center should be contacted at 1-800-222-1222.

Drug Interactions

There are currently no documented drug interactions associated with this medication. Additionally, there are no known interactions with laboratory tests. As such, no specific recommendations for dosage adjustments or monitoring are warranted at this time.

Packaging & NDC

Below are the non-prescription pack sizes of Up and up Daytime Childrens Multi Symptom Cold (dextromethorphan hydrobromide, guaifenesin, and phenylephrine hydrochloride). Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Up and up Daytime Childrens Multi Symptom Cold.
Details

Pediatric Use

Pediatric patients should not use this medication if they are currently taking a prescription monoamine oxidase inhibitor (MAOI) or within 2 weeks of discontinuing an MAOI. Prior to administration, it is advisable to consult a healthcare professional if the child has any of the following conditions: heart disease, high blood pressure, thyroid disease, diabetes, cough associated with excessive phlegm, or a persistent or chronic cough, such as that which occurs with asthma.

For dosing, children aged 6 years to under 12 years may receive 10 mL every 4 hours, while those aged 4 to under 6 years should receive 5 mL every 4 hours. This medication is not recommended for children under 4 years of age.

Geriatric Use

There is no specific information regarding the use of this medication in geriatric patients. The prescribing information primarily emphasizes pediatric use and does not provide any recommendations concerning age considerations, dosage adjustments, safety concerns, or special precautions for elderly patients.

Healthcare providers should exercise caution when prescribing this medication to geriatric patients, given the absence of data on its safety and efficacy in this population. Monitoring for potential adverse effects and therapeutic responses is advisable, as elderly patients may have different pharmacokinetic and pharmacodynamic profiles compared to younger populations.

Pregnancy

The safety of this product during pregnancy has not been established. Pregnant patients or those planning to become pregnant should consult a healthcare professional prior to use, as there may be potential risks to the fetus. Specific studies or data regarding fetal outcomes are not provided in the prescribing information. No specific dosage modifications for pregnant individuals are mentioned; however, it is strongly advised to seek medical advice before using this product during pregnancy.

Lactation

There are no specific warnings or recommendations regarding the use of this product in nursing mothers. Additionally, there is no information available about the potential for excretion in breast milk or any associated risks to breastfed infants.

Renal Impairment

Patients with renal impairment have not been specifically addressed in the prescribing information regarding dosage adjustments, special monitoring, or safety considerations. Therefore, healthcare professionals should exercise caution when prescribing this medication to patients with reduced kidney function, as the absence of detailed guidance necessitates careful clinical judgment and monitoring of these patients.

Hepatic Impairment

Patients with hepatic impairment have not been specifically studied in relation to this medication. Consequently, there are no established dosage adjustments, special monitoring requirements, or precautions outlined for individuals with compromised liver function. It is recommended that healthcare providers exercise caution when prescribing this medication to patients with hepatic impairment, given the lack of data on its safety and efficacy in this population. Regular monitoring of liver function may be prudent in these cases, although specific parameters are not defined in the prescribing information.

Overdosage

In the event of an overdose, it is imperative to seek immediate medical assistance. Healthcare professionals are advised to contact a Poison Control Center without delay. The national hotline for poison control is available at 1-800-222-1222.

Prompt intervention is crucial in managing overdose situations. Symptoms may vary depending on the substance involved, and healthcare providers should be prepared to assess and address any potential complications that may arise. It is essential to monitor the patient closely and provide supportive care as needed.

Management procedures should include a thorough evaluation of the patient's condition, including vital signs and any presenting symptoms. Depending on the severity of the overdose, treatment may involve decontamination, administration of antidotes, or other supportive measures as deemed appropriate by the medical team.

Nonclinical Toxicology

No teratogenic or non-teratogenic effects have been reported in the available nonclinical studies. Additionally, there is no information regarding animal pharmacology and toxicology. The absence of data limits the assessment of potential risks associated with the compound in these areas.

Postmarketing Experience

No postmarketing experience details are available in the insert text.

Patient Counseling

Healthcare providers should advise patients to keep this medication out of reach of children to prevent accidental ingestion. In the event of an overdose, patients should be instructed to seek medical help immediately or contact a Poison Control Center at 1-800-222-1222.

It is crucial to inform patients that this product should not be used in children who are currently taking a prescription monoamine oxidase inhibitor (MAOI) or within two weeks of stopping such medication. Patients should be encouraged to consult with a doctor or pharmacist if they are uncertain whether their child's prescription includes an MAOI.

Patients should be instructed to discontinue use and consult a doctor if they experience nervousness, dizziness, or sleeplessness. Additionally, they should seek medical advice if symptoms do not improve within seven days, or if they occur alongside fever. Patients should also be made aware that a cough lasting more than seven days, recurring cough, or cough accompanied by fever, rash, or persistent headache may indicate a serious condition and warrants medical evaluation.

While using this product, patients must be reminded to adhere strictly to the recommended dosage and not exceed the directed amount. Furthermore, healthcare providers should advise patients to consult a doctor before use if the child has any of the following conditions: heart disease, high blood pressure, thyroid disease, diabetes, a cough that produces excessive phlegm, or a persistent or chronic cough, such as that associated with asthma.

Storage and Handling

The product is supplied in a configuration that includes a dosing cup. It is essential to store the product at room temperature, ensuring that it is not refrigerated. Proper handling includes utilizing the dosing cup provided to ensure accurate dosing.

Additional Clinical Information

The medication is administered orally. There are no additional details available regarding laboratory tests, abuse information, patient counseling, or postmarketing experience.

Drug Information (PDF)

This file contains official product information for Up and up Daytime Childrens Multi Symptom Cold, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Data Generation & Sources

This page was automatically generated and is maintained by the AllDrugs AI Data-Science Team. It was built from the FDA Structured Product Label (DailyMed) for Up and up Daytime Childrens Multi Symptom Cold, retrieved by a validated AI data-extraction workflow.

All FDA-listed dosage forms and strengths are shown in the Packaging & NDC Codes section above. Regulatory status appears in the Summary Information panel above and was verified in the FDA National Drug Code directory and the NSDE NDC Directory daily file.

Note: an automated daemon monitors NSDE checksums; when the record for this NDC changes, the new file is pulled instantly and this page is refreshed.

No human clinician has reviewed this version.

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Orange Book data shown on this page are limited to Regulatory Status (Rx), Established Pharmacologic Class (EPC), and Mechanism of Action (MoA).

Regulatory data notice: Information on this page is reproduced verbatim from FDA public databases (NSDE, Orange Book, Purple Book, DailyMed SPL). NDA/ANDA drugs are FDA-approved, BLA biologics are FDA-licensed. Inclusion alone does not guarantee current market availability or imply FDA endorsement.

Medical disclaimer: This AI-generated content is provided for educational purposes only and does not constitute medical advice. Always consult a licensed healthcare professional for diagnosis or treatment decisions.