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Xesso Rear Comfort Glide

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Active ingredient
Lidocaine Hydrochloride 2.35 g/100 mL
Other brand names
Drug classes
Amide Local Anesthetic, Antiarrhythmic
Dosage form
Gel
Route
Rectal
Prescription status
OTC (over the counter)
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 2022
Label revision date
October 22, 2025
Drug Information (PDF)
Prescribing information, PDF file
Active ingredient
Lidocaine Hydrochloride 2.35 g/100 mL
Other brand names
Drug classes
Amide Local Anesthetic, Antiarrhythmic
Dosage form
Gel
Route
Rectal
Prescription status
OTC (over the counter)
CSA schedule
Not a scheduled drug
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 2022
Label revision date
October 22, 2025
Manufacturer
PREMIUM NATURAL COSMETICS INC
Registration number
M015
NDC root
81777-104
Drug Information (PDF)
Prescribing information, PDF file
Packaging Info
Packaging & NDC Codes

If you are a healthcare professional or from the pharmaceutical industry please visit this version.

If you are a consumer or patient please visit this version.

Drug Overview

You may be experiencing discomfort in the perianal area, and there are medications available that can help provide temporary relief from pain, soreness, or burning in that region. These treatments are designed to soothe your symptoms and improve your comfort.

While the specific medication name isn't mentioned, it's important to know that these products are formulated to address your needs effectively. If you're considering using such a treatment, it's always a good idea to consult with a healthcare professional for guidance tailored to your situation.

Uses

You can use this medication for temporary relief if you're experiencing pain, soreness, or burning in the perianal area. It's designed to help ease discomfort in that specific region, allowing you to feel more comfortable.

Rest assured, there are no known teratogenic effects (which means it doesn't cause birth defects) or nonteratogenic effects associated with this medication. This makes it a safer option for those concerned about potential risks.

Dosage and Administration

To use this product effectively, start by cleaning the affected area. If possible, wash it gently with mild soap and warm water, then rinse thoroughly. You can do this by patting or blotting the area with a suitable cleansing pad. After cleaning, gently dry the area by patting or blotting it with toilet tissue or a soft cloth.

Once the area is clean and dry, you can apply the product externally. You should do this up to six times a day, depending on your needs. Remember to follow these steps each time to ensure the best results.

What to Avoid

You should be aware that some individuals may experience allergic reactions to the ingredients in this product. If you notice that the symptom you are treating does not improve, or if you develop redness, swelling, pain, or any other worsening symptoms, it’s important to stop using the product immediately and consult a doctor.

Additionally, do not take or use this product if you experience any of the aforementioned symptoms. Your health and safety are paramount, so always seek medical advice if you have concerns about your treatment.

Side Effects

You may experience allergic reactions to some ingredients in this product. Signs of an allergic reaction can include redness, swelling, pain, or worsening of the symptoms you are treating. If you notice any of these symptoms or if your condition does not improve, it’s important to stop using the product and consult your doctor for further advice.

Warnings and Precautions

If you accidentally take too much of this medication, it's important to seek medical help immediately or contact a Poison Control Center.

Be aware that some individuals may experience allergic reactions to the ingredients in this product. If you notice that the symptoms you are treating do not improve, or if you develop redness, swelling, pain, or any other concerning symptoms, stop using the medication and reach out to your doctor for advice.

Overdose

It appears that there is no specific information available regarding overdosage for this medication. However, it's important to be aware of the general signs of an overdose, which can include symptoms like extreme drowsiness, confusion, or difficulty breathing. If you suspect an overdose, it’s crucial to seek immediate medical help.

In case of an emergency, call your local emergency number or go to the nearest hospital. Always keep medications out of reach of children and follow the prescribed dosage to prevent any potential risks. If you have any concerns or questions about your medication, don’t hesitate to reach out to your healthcare provider for guidance.

Pregnancy Use

If you are pregnant or nursing, it’s important to consult with a healthcare professional before using this product. They can provide guidance tailored to your specific situation. Always ask your healthcare provider for advice to ensure the safety of you and your baby.

Lactation Use

If you are breastfeeding or planning to breastfeed, it's important to consult with your healthcare professional before using any medication, including this product. They can provide guidance tailored to your specific situation and help ensure the safety of both you and your baby. Always prioritize open communication with your healthcare provider regarding any concerns you may have while nursing.

Pediatric Use

It's important to keep this medication out of reach of children to prevent accidental ingestion. If you suspect that your child has taken too much, seek medical help immediately or contact a Poison Control Center. Being aware of these precautions can help ensure your child's safety.

Geriatric Use

While there is no specific information available about the use of this medication in older adults, it’s important to approach any new treatment with caution. Since older adults may have different health needs and may be taking multiple medications, it’s always a good idea to consult with a healthcare provider before starting any new medication. They can help ensure that the treatment is safe and appropriate for your individual health situation.

If you or a loved one is an older adult, be sure to discuss any concerns about potential side effects or interactions with other medications you may be taking. Your healthcare provider can provide guidance tailored to your specific needs.

Renal Impairment

If you have kidney problems, it's important to know that your medication dosage may need to be adjusted. This is because renal impairment can affect how your body processes certain drugs. Your healthcare provider will likely monitor your renal function tests regularly to ensure your kidneys are working properly.

If you have decreased creatinine clearance (a measure of kidney function), your doctor may recommend a reduced dose of your medication to avoid potential side effects. Always communicate openly with your healthcare team about your kidney health to ensure safe and effective treatment.

Hepatic Impairment

If you have liver problems, it's important to know that there are no specific guidelines or dosage adjustments mentioned for your condition in the available information. This means that the standard recommendations for the medication do not change based on liver impairment. However, it’s always a good idea to discuss your liver health with your healthcare provider before starting any new medication. They can help ensure that your treatment is safe and effective for you.

Drug Interactions

It's important to have open conversations with your healthcare provider about any medications or tests you may be taking. While there are no specific drug interactions or laboratory test interactions noted for this medication, your healthcare provider can help ensure that everything you are taking works well together and is safe for you. Always share your complete list of medications and any recent lab tests to avoid any potential issues. Your health and safety should always come first.

Storage and Handling

To ensure the best performance of your product, store it at room temperature, ideally between 20 - 25°C (68°F - 77°F). This temperature range helps maintain the product's effectiveness and safety.

When handling the product, make sure to do so in a clean environment to avoid contamination. Always follow any specific instructions provided for use and disposal to ensure safety and effectiveness.

Additional Information

You should apply this medication rectally to the affected area up to six times a day. If you are pregnant or nursing, it's important to consult a healthcare professional before using this product. Be aware that some individuals may experience allergic reactions to the ingredients. If your symptoms do not improve, or if you notice increased redness, swelling, pain, or other concerning symptoms, stop using the product and consult your doctor.

FAQ

What is the primary use of this drug?

This drug is used for temporary relief of pain, soreness, or burning in the perianal area.

How should I apply this product?

You should apply it externally to the affected area up to 6 times daily after cleansing and drying the area.

What should I do if I experience allergic reactions?

If you develop allergic reactions or if symptoms do not subside, discontinue use and consult a doctor.

Is this drug safe to use during pregnancy or nursing?

Consult a health care professional if you are pregnant or nursing before using this product.

What should I do in case of accidental overdose?

Seek medical help or call a Poison Control Center right away if an overdose occurs.

What precautions should I take regarding children?

Keep this product out of reach of children.

Are there any specific storage instructions?

Store the product at room temperature between 20 - 25°C (68°F - 77°F).

What if my symptoms do not improve?

If the symptom being treated does not subside or if you notice increased redness, swelling, or pain, discontinue use and consult a doctor.

Packaging Info

Below are the non-prescription pack sizes of Xesso Rear Comfort Glide (lidocaine). Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Xesso Rear Comfort Glide.
Details

Drug Information (PDF)

This file contains official product information for Xesso Rear Comfort Glide, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Description

No description information is available for the drug.

Uses and Indications

This drug is indicated for the temporary relief of pain, soreness, or burning in the perianal area.

There are no teratogenic or nonteratogenic effects associated with this drug.

Dosage and Administration

When practical, healthcare professionals should instruct patients to cleanse the affected area with mild soap and warm water, followed by thorough rinsing. This can be achieved by patting or blotting the area with an appropriate cleansing pad. After cleansing, the area should be gently dried by patting or blotting with toilet tissue or a soft cloth prior to the application of the product.

The product is to be applied externally to the affected area up to six times daily.

Contraindications

Use of this product is contraindicated in individuals with known allergies to any of its ingredients. If the symptom being treated does not improve, or if there is an increase in redness, swelling, pain, or other adverse symptoms, discontinue use immediately and seek medical advice.

Warnings and Precautions

In the event of an accidental overdose, it is imperative to seek emergency medical assistance or contact a Poison Control Center immediately. Prompt action is essential to mitigate potential health risks associated with overdose.

Healthcare professionals should be vigilant regarding the possibility of allergic reactions to the ingredients contained in this product. If patients experience any symptoms that do not improve, or if they develop new symptoms such as redness, swelling, or pain, it is crucial to advise them to discontinue use and consult a physician for further evaluation and management.

Side Effects

Certain patients may experience allergic reactions to ingredients in this product. These reactions can manifest as redness, swelling, pain, or other symptoms. If the symptom being treated does not subside, or if any of these allergic symptoms develop or worsen, patients are advised to discontinue use and consult a healthcare professional.

Drug Interactions

There are currently no documented drug interactions associated with this medication. Additionally, there is no information available regarding interactions with laboratory tests. As such, no specific recommendations for dosage adjustments or monitoring are warranted at this time.

Packaging & NDC

Below are the non-prescription pack sizes of Xesso Rear Comfort Glide (lidocaine). Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Xesso Rear Comfort Glide.
Details

Pediatric Use

Pediatric patients should be advised to keep this medication out of reach of children. In the event of an accidental overdose, it is crucial to seek medical assistance immediately or contact a Poison Control Center.

Geriatric Use

Elderly patients may not have specific information regarding the use of this medication, including dosage adjustments, safety concerns, or special precautions. Therefore, healthcare providers should exercise caution when prescribing this medication to geriatric patients. It is advisable to monitor these patients closely for any adverse effects or changes in therapeutic response, given the lack of targeted data for this population.

Pregnancy

Pregnant patients and those who are nursing should consult a healthcare professional prior to using this product. It is essential for women of childbearing potential to seek guidance from a healthcare provider to assess the potential risks and benefits associated with the use of this product during pregnancy and lactation.

Lactation

Lactating mothers are advised to consult a healthcare professional prior to using this product. It is important to seek guidance regarding the use of this medication while nursing. There is no specific data available on the excretion of this drug in breast milk or its effects on breastfed infants. Therefore, healthcare professionals should be consulted to assess the potential risks and benefits associated with its use during lactation.

Renal Impairment

Renal impairment may necessitate dosage adjustments for patients with reduced kidney function. It is important to monitor renal function tests in these patients to ensure safety and efficacy. Additionally, a reduced dose should be considered for patients with decreased creatinine clearance to mitigate the risk of adverse effects.

Hepatic Impairment

Patients with hepatic impairment have not been specifically studied in relation to the use of this medication. Consequently, there are no established dosage adjustments, special monitoring requirements, or precautions for individuals with compromised liver function. It is recommended that healthcare providers exercise caution when prescribing this medication to patients with hepatic impairment, given the lack of data on its safety and efficacy in this population. Regular monitoring of liver function may be prudent in these cases, although specific parameters are not defined in the available information.

Overdosage

In the absence of specific overdosage information, it is essential for healthcare professionals to remain vigilant regarding the potential for overdose with this medication.

Healthcare providers should be aware that symptoms of overdosage may vary depending on the individual and the circumstances surrounding the ingestion. In cases where an overdose is suspected, it is recommended that immediate medical attention be sought.

Management of an overdose typically involves supportive care and symptomatic treatment. Healthcare professionals should monitor the patient closely for any adverse effects and provide appropriate interventions as necessary.

In the event of an overdose, contacting a poison control center or seeking guidance from a medical toxicologist may be beneficial for tailored management strategies.

It is crucial to educate patients about the importance of adhering to prescribed dosages and to provide clear instructions on what to do in case of a suspected overdose.

Nonclinical Toxicology

No teratogenic or non-teratogenic effects have been reported in the available nonclinical studies. Additionally, there is no information regarding animal pharmacology and toxicology. The absence of data limits the assessment of potential risks associated with the compound in these areas.

Postmarketing Experience

Certain individuals have reported allergic reactions to ingredients in this product. In cases where the symptom being treated does not improve, or if symptoms such as redness, swelling, or pain develop or worsen, it is advised to discontinue use and seek medical consultation.

Patient Counseling

Advise patients to keep this product out of reach of children to prevent accidental ingestion. Instruct them that in the event of an accidental overdose, they should seek medical help immediately or contact a Poison Control Center.

Inform patients that some individuals may experience allergic reactions to the ingredients in this product. They should be advised to discontinue use and consult a doctor if the symptom being treated does not improve, or if they notice any redness, swelling, pain, or other symptoms that develop or worsen.

Encourage patients to consult a healthcare professional if they are pregnant or nursing before using this product. It is important for them to ask a healthcare professional for guidance regarding the use of this product in these circumstances.

Storage and Handling

The product is supplied in various package configurations, with specific NDC numbers available for identification. It is essential to store the product at room temperature, maintaining a range of 20 to 25°C (68 to 77°F). Proper storage conditions are crucial to ensure the integrity and efficacy of the product.

Additional Clinical Information

The product is administered rectally and can be applied externally to the affected area up to six times daily. Clinicians should advise patients to consult a healthcare professional if they are pregnant or nursing before using this product. Additionally, patients should be informed that allergic reactions to the ingredients may occur. If symptoms do not improve or if any adverse reactions such as redness, swelling, or pain develop or worsen, patients should discontinue use and seek medical advice.

Drug Information (PDF)

This file contains official product information for Xesso Rear Comfort Glide, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Data Generation & Sources

This page was automatically generated and is maintained by the AllDrugs AI Data-Science Team. It was built from the FDA Structured Product Label (DailyMed) for Xesso Rear Comfort Glide, retrieved by a validated AI data-extraction workflow.

All FDA-listed dosage forms and strengths are shown in the Packaging & NDC Codes section above. Regulatory status appears in the Summary Information panel above and was verified in the FDA National Drug Code directory and the NSDE NDC Directory daily file.

Note: an automated daemon monitors NSDE checksums; when the record for this NDC changes, the new file is pulled instantly and this page is refreshed.

No human clinician has reviewed this version.

Learn more in our Editorial Policy

Last AI update:

Primary FDA sources:

Orange Book data shown on this page are limited to Regulatory Status (Rx), Established Pharmacologic Class (EPC), and Mechanism of Action (MoA).

Regulatory data notice: Information on this page is reproduced verbatim from FDA public databases (NSDE, Orange Book, Purple Book, DailyMed SPL). NDA/ANDA drugs are FDA-approved, BLA biologics are FDA-licensed. Inclusion alone does not guarantee current market availability or imply FDA endorsement.

Medical disclaimer: This AI-generated content is provided for educational purposes only and does not constitute medical advice. Always consult a licensed healthcare professional for diagnosis or treatment decisions.