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Zicam Extreme Congestion Relief

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Active ingredient
Oxymetazoline Hydrochloride 0.5 mg/1 mL
Other brand names
Drug class
Vasoconstrictor
Dosage form
Spray
Route
Nasal
Prescription status
OTC (over the counter)
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 2021
Label revision date
December 31, 2025
Drug Information (PDF)
Prescribing information, PDF file
Active ingredient
Oxymetazoline Hydrochloride 0.5 mg/1 mL
Other brand names
Drug class
Vasoconstrictor
Dosage form
Spray
Route
Nasal
Prescription status
OTC (over the counter)
CSA schedule
Not a scheduled drug
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 2021
Label revision date
December 31, 2025
Manufacturer
Church & Dwight Co. , Inc.
Registration number
M012
NDC root
10237-464
Drug Information (PDF)
Prescribing information, PDF file
Packaging Info
Packaging & NDC Codes

If you are a healthcare professional or from the pharmaceutical industry please visit this version.

If you are a consumer or patient please visit this version.

Drug Overview

ZICAM is a nasal decongestant that contains oxymetazoline HCl (a medication that helps relieve nasal congestion) at a concentration of 0.05%. It is designed to provide fast and powerful relief from extreme nasal and sinus congestion caused by the common cold, hay fever, and upper respiratory allergies. This no-drip liquid nasal spray not only helps clear nasal passages but also temporarily relieves sinus congestion and pressure by shrinking swollen membranes.

With a volume of 0.50 FL OZ (15 mL), ZICAM offers up to 12 hours of relief, making it a convenient option for those seeking to alleviate discomfort from nasal congestion and sinus pressure. Additionally, it contains soothing aloe vera to enhance your experience while using the spray.

Uses

If you're dealing with nasal congestion from the common cold, hay fever, or upper respiratory allergies, this medication can provide temporary relief. It works by helping to clear your nasal passages and shrink swollen membranes, which can ease your breathing and reduce sinus congestion and pressure.

By using this medication, you can find some comfort from the discomfort of nasal congestion, allowing you to breathe more easily.

Dosage and Administration

When using this nasal spray, adults and children aged 6 to under 12 years should apply 2 or 3 sprays in each nostril. You can do this every 10 to 12 hours, but make sure not to exceed 2 doses in a 24-hour period. If your child is under 6 years old, it's important to consult a doctor before use.

To use the spray, start by opening the bottle. Hold the actuator (the part you squeeze) and turn the cap to remove it. Grip the bottle with your thumb at the bottom and your fingers around the nozzle. Before your first use, you need to prime the pump by pressing it down several times until you see a fine mist. When you're ready to spray, place the tip of the nozzle just inside your nostril, about 1/8 inch in, and pump 2 or 3 times in each nostril while sniffing deeply. After using the spray, remember to wipe the nozzle clean and securely close the cap by turning it until it clicks.

What to Avoid

It's important to use this medication responsibly to ensure your safety and well-being. You should never use it for more than three days, as prolonged use can lead to worsening nasal congestion. Always follow the directions provided and avoid using more than the recommended amount.

Additionally, be cautious about sharing this medication; using the same container with others can increase the risk of spreading infections. By adhering to these guidelines, you can help prevent potential misuse and ensure the medication works effectively for you.

Side Effects

You may experience some temporary discomfort when using this product, such as burning, stinging, sneezing, or an increase in nasal discharge. If you use it frequently or for a long time, you might find that nasal congestion returns or worsens. It's also important to note that sharing this product with others can lead to the spread of infection.

If your symptoms continue despite using the product, please stop using it and consult a doctor for further advice.

Warnings and Precautions

Before using this product, it's important to consult your doctor if you have any of the following conditions: heart disease, high blood pressure, thyroid disease, diabetes, or difficulty urinating due to an enlarged prostate gland. Always follow the directions carefully—do not exceed the recommended dosage or use it for more than three days, as doing so may worsen nasal congestion. You might experience temporary discomfort like burning, stinging, sneezing, or increased nasal discharge. Additionally, sharing this product with others can lead to the spread of infection.

Keep this product out of reach of children. If a child accidentally swallows it, seek medical help or contact a Poison Control Center immediately. If your symptoms do not improve, stop using the product and reach out to your doctor for further advice.

Overdose

If you or someone else has swallowed a medication and you suspect an overdose, it’s important to act quickly. You should seek medical help immediately or contact a Poison Control Center for guidance.

Signs of an overdose can vary, but they may include unusual symptoms that are not typical for the medication. Always err on the side of caution and reach out for professional assistance if you have any concerns about an overdose. Your safety is the top priority.

Pregnancy Use

If you are pregnant or breastfeeding, it’s important to consult with a healthcare professional before using this medication. They can provide guidance on whether it’s safe for you and your baby. Always prioritize your health and the health of your child by seeking expert advice.

Lactation Use

If you are pregnant or breastfeeding, it’s important to consult with a healthcare professional before using any medication. This ensures that you understand any potential risks and can make informed decisions about your health and the health of your baby. Always prioritize open communication with your doctor regarding your breastfeeding journey.

Pediatric Use

If you have a child under 6 years old, it's important to consult a doctor before using this medication. For children aged 6 to under 12 years, you can use it with adult supervision. The recommended dosage is 2 or 3 sprays in each nostril, but make sure not to use it more than once every 10 to 12 hours. Additionally, do not exceed 2 doses in a 24-hour period to ensure your child's safety. Always follow these guidelines to help keep your child healthy.

Geriatric Use

While there is no specific information available about the use of this medication in older adults, it’s important to approach any new treatment with caution. Since older adults may have different health needs and responses to medications, you should always consult with a healthcare provider before starting any new medication. They can help determine the right dosage and monitor for any potential side effects, ensuring that the treatment is safe and effective for you or your loved one.

Renal Impairment

If you have kidney problems, it's important to consult your doctor before using this medication, especially if you experience difficulty urinating due to an enlarged prostate gland. Your healthcare provider can help determine if this medication is safe for you and may suggest necessary adjustments to your dosage or monitoring based on your kidney function. Always prioritize open communication with your doctor regarding your kidney health and any medications you are considering.

Hepatic Impairment

If you have liver problems, it's important to know that the drug insert does not provide specific information about dosage adjustments, special monitoring, or precautions for your condition. This means that there are no tailored guidelines for how this medication should be used if you have hepatic impairment (issues with liver function).

Before starting any new medication, including this one, you should discuss your liver health with your healthcare provider. They can help determine the best approach for your treatment and ensure your safety.

Drug Interactions

It's important to have open conversations with your healthcare provider about any medications or tests you may be taking. While there are no specific drug interactions or laboratory test interactions noted for this medication, your healthcare provider can help ensure that everything you are taking works well together and is safe for you.

Always feel free to ask questions and share your complete list of medications and any lab tests you may be undergoing. This way, you can receive the best possible care tailored to your needs.

Storage and Handling

You can store and handle the product safely without any specific instructions provided. This means you should keep it in a clean, dry place, away from extreme temperatures or direct sunlight to ensure its integrity.

When using the product, always maintain a sterile field (a clean area free from germs) to prevent contamination. If you have any questions about disposal or specific handling techniques, please consult your healthcare provider for guidance.

Additional Information

You will use this medication through your nose (nasal administration). If you are pregnant or breastfeeding, it's important to consult a healthcare professional before using this product. Always keep it out of reach of children. If a child accidentally swallows it, seek medical help or contact a Poison Control Center immediately.

FAQ

What is ZICAM used for?

ZICAM is used to temporarily relieve nasal congestion due to the common cold, hay fever, and upper respiratory allergies.

How does ZICAM work?

ZICAM contains Oxymetazoline HCl, which temporarily relieves nasal and sinus congestion by shrinking swollen membranes and helping to clear nasal passages.

What are the side effects of ZICAM?

Possible side effects include temporary discomfort such as burning, stinging, sneezing, or increased nasal discharge. Frequent use may worsen nasal congestion.

How should I use ZICAM?

For adults and children aged 6 to under 12, use 2 or 3 sprays in each nostril every 10 to 12 hours, not exceeding 2 doses in 24 hours. Children under 6 should consult a doctor.

Are there any precautions I should take?

Do not use ZICAM for more than 3 days, and consult a doctor if you have heart disease, high blood pressure, thyroid disease, diabetes, or trouble urinating due to an enlarged prostate.

Can I use ZICAM if I am pregnant or breastfeeding?

If you are pregnant or breastfeeding, ask a health professional before using ZICAM.

What should I do if symptoms persist?

If symptoms persist, stop using ZICAM and consult a doctor.

What should I do if I accidentally swallow ZICAM?

Keep ZICAM out of reach of children. If swallowed, seek medical help or contact a Poison Control Center immediately.

Packaging Info

Below are the non-prescription pack sizes of Zicam Extreme Congestion Relief (oxymetazoline hydrochloride). Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Zicam Extreme Congestion Relief.
Details

Drug Information (PDF)

This file contains official product information for Zicam Extreme Congestion Relief, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Description

No description information is available for the specified drug.

Uses and Indications

This drug is indicated for the temporary relief of nasal congestion associated with the common cold, hay fever, and upper respiratory allergies. It also provides temporary relief from sinus congestion and pressure, aids in clearing nasal passages, and shrinks swollen membranes.

There are no teratogenic or nonteratogenic effects associated with this drug.

Dosage and Administration

Adults and children aged 6 to under 12 years, under adult supervision, may receive 2 or 3 sprays in each nostril. This administration should not occur more frequently than every 10 to 12 hours, and the total number of doses should not exceed 2 in any 24-hour period. For children under 6 years of age, consultation with a physician is recommended prior to use.

To properly use the nasal spray pump, the following steps should be followed:

  1. To open the device, hold the actuator and squeeze while turning the cap.

  2. Hold the bottle with the thumb at the bottom and the nozzle between the fingers.

  3. Before the initial use, prime the pump by depressing it several times.

  4. Position the tip of the nozzle just past the nasal opening, approximately 1/8 inch.

  5. Administer 2 or 3 sprays in each nostril without tilting the head, and sniff deeply during administration.

  6. After use, wipe the nozzle clean to maintain hygiene.

  7. To close the device, turn the cap until it clicks securely.

Contraindications

Use is contraindicated in the following situations:

  • Use is not recommended for more than 3 days, as prolonged use may lead to the recurrence or worsening of nasal congestion.

  • Do not exceed the directed dosage, as misuse may result in adverse effects.

  • The product should not be used by multiple individuals, as this may facilitate the spread of infection.

Warnings and Precautions

Healthcare professionals should be aware of the following warnings and precautions associated with the use of this product.

Patients should be advised to consult a physician prior to use if they have any of the following conditions: heart disease, high blood pressure, thyroid disease, diabetes, or difficulty urinating due to an enlarged prostate gland. These conditions may increase the risk of adverse effects or complications.

When administering this product, it is crucial to adhere to the recommended dosage. Patients should not exceed the directed use and should limit the duration of use to no more than three days. Prolonged or frequent use may lead to a recurrence or worsening of nasal congestion. Additionally, users may experience temporary discomfort, which can include burning, stinging, sneezing, or an increase in nasal discharge. It is also important to note that sharing this product among multiple users may facilitate the spread of infection.

In the event of accidental ingestion, the product should be kept out of reach of children. Immediate medical assistance should be sought, or contact with a Poison Control Center should be made without delay.

Healthcare professionals should instruct patients to discontinue use and seek medical advice if symptoms persist. This precaution is essential to ensure patient safety and to address any underlying conditions that may require further evaluation.

Side Effects

Patients using this product may experience temporary discomfort, which can include burning, stinging, sneezing, or an increase in nasal discharge. These reactions are generally mild and transient. However, frequent or prolonged use of the product may lead to a recurrence or worsening of nasal congestion.

It is important to note that the use of this container by more than one person may pose a risk of spreading infection.

Patients are advised to discontinue use and consult a healthcare professional if symptoms persist.

Drug Interactions

There are currently no documented drug interactions associated with this medication. Additionally, there is no information available regarding interactions with laboratory tests. As such, no specific recommendations for dosage adjustments or monitoring are warranted at this time.

Packaging & NDC

Below are the non-prescription pack sizes of Zicam Extreme Congestion Relief (oxymetazoline hydrochloride). Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Zicam Extreme Congestion Relief.
Details

Pediatric Use

Pediatric patients under 6 years of age should consult a healthcare professional before use. For children aged 6 to under 12 years, the recommended dosage is 2 or 3 sprays in each nostril, administered no more frequently than every 10 to 12 hours. It is important not to exceed 2 doses within a 24-hour period. Adult supervision is advised during administration for this age group.

Geriatric Use

There is no specific information available regarding the use of this medication in geriatric patients, including dosage adjustments, safety concerns, or special precautions. Healthcare providers should exercise caution when prescribing this medication to elderly patients, as individual responses may vary. It is advisable to monitor these patients closely for any adverse effects or changes in efficacy, given the lack of targeted data for this population.

Pregnancy

Pregnant patients and those who are breastfeeding should consult a healthcare professional prior to using this medication. The potential risks and benefits must be carefully considered, as the effects on fetal outcomes and lactation are not fully established. It is essential for women of childbearing potential to discuss their individual circumstances with a healthcare provider to ensure safe use during pregnancy and lactation.

Lactation

Lactating mothers are advised to consult a health professional prior to using this medication. There is currently no available data on the excretion of this drug in human breast milk or its effects on breastfed infants. Therefore, caution is recommended when administering this medication to lactating individuals.

Renal Impairment

Patients with renal impairment should consult a healthcare professional prior to use, particularly if they experience difficulty urinating due to an enlarged prostate gland. It is essential to assess renal function and consider potential dosing adjustments or monitoring requirements based on the degree of impairment.

Hepatic Impairment

Patients with hepatic impairment have not been specifically studied in relation to this medication. Consequently, there are no dosage adjustments, special monitoring requirements, or precautions outlined for individuals with compromised liver function. It is recommended that healthcare providers exercise caution when prescribing this medication to patients with hepatic impairment, given the lack of data on its safety and efficacy in this population. Regular monitoring of liver function may be prudent in these cases, although specific parameters are not defined in the prescribing information.

Overdosage

In the event of an overdosage, immediate medical assistance is crucial. If the substance is ingested, it is imperative to seek medical help or contact a Poison Control Center without delay.

Healthcare professionals should be aware that prompt intervention can significantly mitigate potential adverse effects associated with overdosage. Symptoms may vary depending on the specific substance involved; therefore, a thorough assessment and monitoring of the patient are essential.

Management procedures may include supportive care and symptomatic treatment as necessary. It is recommended that healthcare providers remain vigilant and prepared to implement appropriate interventions based on the clinical presentation of the patient.

Nonclinical Toxicology

No teratogenic or non-teratogenic effects have been reported in the available nonclinical studies. Additionally, there is no information regarding animal pharmacology and toxicology. The absence of data limits the assessment of potential risks associated with the use of the compound in question. Further studies may be necessary to elucidate these aspects of nonclinical toxicology.

Postmarketing Experience

No postmarketing experience details are available in the insert text.

Patient Counseling

Healthcare providers should advise patients to keep this product out of reach of children to prevent accidental ingestion. Instruct patients that if the product is swallowed, they should seek medical help or contact a Poison Control Center immediately.

Patients should be informed to stop using the product and consult a doctor if symptoms persist. When using this product, it is crucial to adhere to the following guidelines: do not exceed the recommended dosage, and do not use the product for more than three consecutive days. Emphasize that frequent or prolonged use may lead to a recurrence or worsening of nasal congestion.

Patients may experience temporary discomfort, including burning, stinging, sneezing, or an increase in nasal discharge while using the product. It is also important to inform patients that sharing this container with others may increase the risk of spreading infection.

Before initiating use, healthcare providers should encourage patients to consult a doctor if they have any of the following conditions: heart disease, high blood pressure, thyroid disease, diabetes, or difficulty urinating due to an enlarged prostate gland.

Storage and Handling

The product is available in various package configurations, with specific NDC numbers assigned for identification. Currently, there are no specific storage or handling instructions provided. It is recommended that healthcare professionals follow standard storage practices for pharmaceutical products, ensuring that the product is stored in a suitable environment to maintain its integrity and efficacy.

Additional Clinical Information

The route of administration for the medication is nasal. Clinicians should advise patients who are pregnant or breastfeeding to consult a health professional prior to use. Additionally, it is important to keep the medication out of reach of children; if ingested, patients should seek medical assistance or contact a Poison Control Center immediately.

Drug Information (PDF)

This file contains official product information for Zicam Extreme Congestion Relief, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Data Generation & Sources

This page was automatically generated and is maintained by the AllDrugs AI Data-Science Team. It was built from the FDA Structured Product Label (DailyMed) for Zicam Extreme Congestion Relief, retrieved by a validated AI data-extraction workflow.

All FDA-listed dosage forms and strengths are shown in the Packaging & NDC Codes section above. Regulatory status appears in the Summary Information panel above and was verified in the FDA National Drug Code directory and the NSDE NDC Directory daily file.

Note: an automated daemon monitors NSDE checksums; when the record for this NDC changes, the new file is pulled instantly and this page is refreshed.

No human clinician has reviewed this version.

Learn more in our Editorial Policy

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Primary FDA sources:

Orange Book data shown on this page are limited to Regulatory Status (Rx), Established Pharmacologic Class (EPC), and Mechanism of Action (MoA).

Regulatory data notice: Information on this page is reproduced verbatim from FDA public databases (NSDE, Orange Book, Purple Book, DailyMed SPL). NDA/ANDA drugs are FDA-approved, BLA biologics are FDA-licensed. Inclusion alone does not guarantee current market availability or imply FDA endorsement.

Medical disclaimer: This AI-generated content is provided for educational purposes only and does not constitute medical advice. Always consult a licensed healthcare professional for diagnosis or treatment decisions.