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Methyl salicylate/Menthol/Capsaicin

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Active ingredients
  • Capsaicin 0.014 mg/1 g
  • Menthol 0.566 mg/1 g
  • Methyl Salicylate 6.79 mg/1 g
Other brand names
Dosage form
Cream
Route
Topical
Prescription status
OTC (over the counter)
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 1999
Label revision date
December 29, 2025
Drug Information (PDF)
Prescribing information, PDF file
Active ingredients
  • Capsaicin 0.014 mg/1 g
  • Menthol 0.566 mg/1 g
  • Methyl Salicylate 6.79 mg/1 g
Other brand names
Dosage form
Cream
Route
Topical
Prescription status
OTC (over the counter)
CSA schedule
Not a scheduled drug
Pregnancy
See Pregnancy Use Section
Lactation
See Lactation Use Section
Marketed in the U.S.
Since 1999
Label revision date
December 29, 2025
Manufacturer
Nnodum Pharmaceuticals
Registration number
M017
NDC root
63044-030
Drug Information (PDF)
Prescribing information, PDF file
Packaging Info
Packaging & NDC Codes

If you are a healthcare professional or from the pharmaceutical industry please visit this version.

If you are a consumer or patient please visit this version.

Drug Overview

This medication is designed for the temporary relief of minor aches and pains in muscles and joints, which can be associated with conditions like arthritis, simple backache, strains, and sprains. It contains purified capsaicin (a compound derived from chili peppers known for its pain-relieving properties) and is recommended by healthcare professionals for its effectiveness.

You can apply this treatment to the affected area up to three to four times a day for optimal results. While you may experience a mild burning sensation upon application, this usually subsides within a few days. If you have any concerns, especially for children under two years of age, it's best to consult a physician.

Uses

If you're dealing with minor aches and pains in your muscles and joints, such as those caused by arthritis, simple backaches, strains, or sprains, this medication can provide temporary relief. Many doctors and pharmacists recommend products that contain purified capsaicin, which is known for its effectiveness in alleviating discomfort.

Rest assured, there are no concerns regarding teratogenic effects (which refer to substances that can cause birth defects) associated with this medication, making it a safer option for those who may be pregnant or planning to become pregnant.

Dosage and Administration

It seems that there are no specific dosage or administration details available for this medication. This means that you should consult your healthcare provider for personalized instructions on how to take or use the medication. They will provide you with the necessary information regarding the correct dosage, how to administer it, and how often you should do so. Always follow their guidance to ensure safe and effective use of the medication.

What to Avoid

There are no specific contraindications, controlled substance classifications, or risks of abuse, misuse, or dependence associated with this medication. This means that, based on the available information, there are no particular situations or conditions under which you should avoid using it. Always consult with your healthcare provider for personalized advice and to ensure that this medication is appropriate for your individual health needs.

Side Effects

When using this product, it's important to be aware of some potential side effects. You should only use it externally and avoid contact with your eyes and mucous membranes. If your condition worsens, or if symptoms last more than 7 days or return shortly after improvement, stop using the product and consult a doctor. Additionally, do not apply it to wounds, broken skin, or areas that are irritated, and avoid tight bandaging or using it with a heating pad.

If you are pregnant or nursing, please consult a healthcare professional before use. Always keep this and all medications out of reach of children. In case of accidental ingestion, seek medical help or contact a poison control center immediately.

Warnings and Precautions

This product is for external use only, so be sure to avoid contact with your eyes and any mucous membranes. If your condition worsens, or if symptoms last longer than 7 days or return after clearing up, stop using the product and consult your doctor. It's important not to apply it to wounds, broken skin, or areas that are irritated, and avoid tight bandaging or using it with a heating pad.

If you are pregnant or nursing, please talk to a healthcare professional before using this product. Always keep it out of reach of children, and if a child accidentally ingests it, seek professional help or contact a poison control center right away.

Overdose

If you accidentally take too much of a medication, it's important to act quickly. You should seek professional assistance or contact a poison control center right away. Signs of an overdose can vary, but they may include unusual symptoms that are not typical for you.

If you notice any concerning changes in your health after taking the medication, don’t hesitate to get help. Remember, it’s always better to be safe and get checked out if you think you might have taken too much.

Pregnancy Use

If you are pregnant or nursing, it’s important to consult with a healthcare professional before using this product. They can provide guidance tailored to your specific situation, ensuring both your health and the health of your baby are prioritized. Always prioritize open communication with your doctor regarding any medications or treatments you are considering during this time.

Lactation Use

If you are breastfeeding or planning to breastfeed, it's important to consult with a healthcare professional before using any medication, including this product. They can provide guidance on how it may affect you and your baby. Always prioritize your health and your baby's well-being by seeking expert advice.

Pediatric Use

When using this medication for children, it's important to follow specific guidelines. For children aged 2 years and older, you can apply it to the affected area up to 3 to 4 times a day. However, if your child is under 2 years old, you should consult a physician (doctor) before using the medication to ensure it's safe for them. Always prioritize your child's health and seek professional advice when needed.

Geriatric Use

While there is no specific information available about the use of this medication in older adults, it’s important to approach any new treatment with caution. If you or a loved one is an older adult, be sure to discuss any potential risks or concerns with your healthcare provider. They can help determine the best approach for your individual health needs, especially since older adults may have different responses to medications compared to younger individuals. Always keep an open line of communication with your doctor about any changes in health or medication effects.

Renal Impairment

If you have kidney problems, it's important to know that there are no specific guidelines or dosage adjustments mentioned for your condition in the available information. This means that the standard recommendations for the medication do not include special monitoring or safety considerations tailored for patients with renal impairment (kidney issues).

Always consult your healthcare provider for personalized advice and to ensure that any medication you take is safe and appropriate for your health situation. They can provide guidance based on your individual needs and kidney function.

Hepatic Impairment

If you have liver problems, it's important to know that the drug insert does not provide specific information about dosage adjustments, special monitoring, or precautions for your condition. This means that there are no tailored guidelines for how this medication may affect you if you have hepatic impairment (liver issues).

Always consult your healthcare provider for personalized advice and to discuss any concerns regarding your liver health and how it may relate to your treatment. They can help ensure that you receive the safest and most effective care based on your individual needs.

Drug Interactions

It's important to have open conversations with your healthcare provider about any medications or tests you may be taking. While there are no specific drug interactions or laboratory test interactions noted for this medication, your healthcare provider can help ensure that everything you are taking works well together and is safe for you. Always share your complete list of medications and any health conditions you have to receive the best care possible.

Storage and Handling

To ensure the best results with Ziks cream, store the 2 oz. tube in a cool, dry place away from direct sunlight. This helps maintain the cream's effectiveness and safety. When handling the tube, make sure to keep the opening clean and avoid touching the tip to prevent contamination.

If you have any leftover cream, dispose of it according to local regulations to ensure safe disposal. Following these guidelines will help you use Ziks cream safely and effectively.

Additional Information

You should apply this medication topically to the affected area, using it no more than 3 to 4 times a day if you are an adult or a child aged 2 years and older. Be aware that you might experience a mild burning sensation when you first apply it, but this usually goes away within a few days. If you apply it less frequently than recommended, you may not get the best pain relief, and the burning sensation could continue.

Remember to wash your hands with soap and water after applying the medication, unless you are treating your hands.

FAQ

What is the recommended application frequency for this product?

For adults and children 2 years of age and older, apply to the affected area not more than 3 to 4 times daily.

What should I do if I am under 2 years of age?

If you are under 2 years of age, consult a physician before use.

What should I expect upon application?

You may experience a passing burning sensation upon application, which generally disappears in several days.

Are there any warnings I should be aware of?

This product is for external use only. Avoid contact with eyes and mucous membranes, and do not apply to wounds or irritated skin.

What should I do if symptoms persist?

If conditions worsen or symptoms persist for more than 7 days, discontinue use and consult a physician.

Can I use this product if I am pregnant or nursing?

If you are pregnant or nursing, seek the advice of a health professional before using this product.

How should I wash my hands after applying the product?

You should wash your hands with soap and water after applying the product, unless you are treating your hands.

What is the active ingredient recommended by doctors?

Products containing purified capsaicin are most recommended by doctors and pharmacists for temporary relief of minor aches and pains.

What is the packaging size of this product?

Ziks cream is supplied in a 2 oz. tube.

Packaging Info

Below are the non-prescription pack sizes of Ziks Arthritis Pain Relief. Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Ziks Arthritis Pain Relief.
Details

Drug Information (PDF)

This file contains official product information for Ziks Arthritis Pain Relief, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Description

No description information is available for the specified drug.

Uses and Indications

This drug is indicated for the temporary relief of minor aches and pains of muscles and joints associated with conditions such as arthritis, simple backache, strains, and sprains. Products containing purified capsaicin are most recommended by healthcare professionals, including doctors and pharmacists, for these indications.

Limitations of Use: There are no teratogenic or nonteratogenic effects associated with this drug.

Dosage and Administration

There is currently no specific dosage and administration information available for this medication. Healthcare professionals are advised to refer to the prescribing information or clinical guidelines for detailed instructions regarding the appropriate dosage, route of administration, and frequency of use. It is essential to consider individual patient factors and clinical judgment when determining the appropriate regimen.

Contraindications

There are no contraindications associated with the use of this product. It is not classified as a controlled substance, and there are no known risks of abuse, misuse, or dependence. Additionally, there are no specific instructions indicating that the product should not be taken or used under any circumstances.

Warnings and Precautions

For external use only, this product should be applied with caution to avoid contact with the eyes and mucous membranes. In the event that conditions worsen, or if symptoms persist for more than 7 days, or if symptoms resolve and then recur within a few days, it is imperative to discontinue use and consult a physician.

This product must not be applied to wounds, damaged or broken skin, or areas of irritation. Should excessive irritation develop, the application should be stopped immediately. Additionally, it is advised not to bandage the area tightly or use this product in conjunction with a heating pad, as this may exacerbate irritation or adverse effects.

Healthcare professionals should advise patients who are pregnant or nursing to seek medical advice prior to using this product, as safety during these conditions has not been fully established.

It is crucial to keep this and all medications out of the reach of children. In the case of accidental ingestion, immediate professional assistance should be sought, or contact with a poison control center is recommended.

Side Effects

Patients using this product should be aware of the following warnings and precautions. This product is for external use only and should not come into contact with the eyes or mucous membranes. In the event that conditions worsen, or if symptoms persist for more than 7 days, or if symptoms clear up and then recur within a few days, patients are advised to discontinue use and consult a physician.

The product should not be applied to wounds, damaged or broken skin, or areas of irritation. If excessive irritation develops, use should be discontinued. It is important to avoid tight bandaging of the area where the product is applied and to refrain from using it in conjunction with a heating pad.

Additionally, as with any medication, pregnant or nursing individuals should seek the advice of a healthcare professional prior to use. This product should be kept out of the reach of children. In the case of accidental ingestion, it is crucial to seek professional assistance or contact a poison control center immediately.

Drug Interactions

There are currently no documented drug interactions associated with the use of this medication. Additionally, there is no information available regarding interactions with laboratory tests. As such, no specific recommendations for dosage adjustments or monitoring are warranted at this time.

Packaging & NDC

Below are the non-prescription pack sizes of Ziks Arthritis Pain Relief. Columns show Packaging, Formulation Type, and Active Ingredient Strength.

Packaging configurations for Ziks Arthritis Pain Relief.
Details

Pediatric Use

Pediatric patients aged 2 years and older may apply the medication to the affected area no more than 3 to 4 times daily. For children under 2 years of age, it is advised to consult a physician prior to use.

Geriatric Use

There is no specific information available regarding the use of this medication in geriatric patients, including dosage adjustments, safety concerns, or special precautions. Healthcare providers should exercise caution when prescribing this medication to elderly patients, as individual responses may vary. It is advisable to monitor these patients closely for any adverse effects or changes in efficacy, given the lack of targeted data for this population.

Pregnancy

Pregnant patients and nursing mothers should seek the advice of a healthcare professional before using this product. The safety of this medication during pregnancy has not been established, and potential risks to fetal outcomes are not fully understood. It is essential for women of childbearing potential to discuss their individual circumstances with their healthcare provider to weigh the benefits and risks associated with the use of this product during pregnancy and lactation.

Lactation

Lactating mothers are advised to seek the advice of a health professional before using this product. There is no specific data available regarding the excretion of this drug in breast milk or its effects on breastfed infants. Therefore, healthcare providers should carefully consider the potential risks and benefits when recommending this product to nursing mothers.

Renal Impairment

There is no specific information available regarding dosage adjustments, special monitoring, or safety considerations for patients with renal impairment. Healthcare professionals should exercise caution when prescribing to patients with reduced kidney function, as the absence of detailed guidance necessitates careful clinical judgment. Regular monitoring of renal function may be advisable in this patient population.

Hepatic Impairment

Patients with hepatic impairment have not been specifically studied in relation to the use of this medication. Consequently, there are no established dosage adjustments, special monitoring requirements, or precautions outlined for individuals with compromised liver function. It is recommended that healthcare providers exercise caution when prescribing this medication to patients with hepatic impairment, given the lack of data on its safety and efficacy in this population. Regular monitoring of liver function may be prudent in these cases, although specific parameters are not defined in the available information.

Overdosage

In the event of accidental ingestion, it is imperative to seek professional assistance or contact a poison control center immediately. Prompt action is crucial to ensure the safety and well-being of the patient.

Healthcare professionals should be aware that symptoms of overdosage may vary depending on the substance involved. Monitoring for any adverse effects is essential, and appropriate management should be initiated based on the clinical presentation.

Management procedures may include supportive care and symptomatic treatment as necessary. It is recommended that healthcare providers remain vigilant and prepared to implement interventions based on the severity of symptoms observed in the patient.

Nonclinical Toxicology

No teratogenic or non-teratogenic effects have been reported in the available nonclinical studies. Additionally, there is no information regarding animal pharmacology and toxicology. The absence of data in these areas limits the understanding of the compound's potential effects in nonclinical settings.

Postmarketing Experience

No postmarketing experience details are provided in the insert.

Patient Counseling

Healthcare providers should advise patients to keep the medication out of reach of children to prevent accidental ingestion or misuse. It is important to emphasize the necessity of safeguarding the medication to ensure the safety of young individuals.

Storage and Handling

Ziks cream is supplied in a 2 oz. tube. It should be stored at controlled room temperature, specifically between 20°C to 25°C (68°F to 77°F). The product must be kept in its original container to protect it from moisture and light. Special handling is not required; however, it is advisable to ensure that the tube is tightly closed when not in use to maintain product integrity.

Additional Clinical Information

The medication is administered topically, with a recommended application frequency of 3 to 4 times daily for adults and children aged 2 years and older. Patients may experience a transient burning sensation upon application, which typically resolves within several days. Clinicians should advise that less frequent applications may not achieve optimal pain relief and could prolong the burning sensation. It is also important for patients to wash their hands with soap and water after application, unless they are treating their hands.

Drug Information (PDF)

This file contains official product information for Ziks Arthritis Pain Relief, including active ingredients, dosage, warnings, and labeling as submitted by the manufacturer for OTC distribution.

View product document (PDF)

Data Generation & Sources

This page was automatically generated and is maintained by the AllDrugs AI Data-Science Team. It was built from the FDA Structured Product Label (DailyMed) for Ziks Arthritis Pain Relief, retrieved by a validated AI data-extraction workflow.

All FDA-listed dosage forms and strengths are shown in the Packaging & NDC Codes section above. Regulatory status appears in the Summary Information panel above and was verified in the FDA National Drug Code directory and the NSDE NDC Directory daily file.

Note: an automated daemon monitors NSDE checksums; when the record for this NDC changes, the new file is pulled instantly and this page is refreshed.

No human clinician has reviewed this version.

Learn more in our Editorial Policy

Last AI update:

Primary FDA sources:

Orange Book data shown on this page are limited to Regulatory Status (Rx), Established Pharmacologic Class (EPC), and Mechanism of Action (MoA).

Regulatory data notice: Information on this page is reproduced verbatim from FDA public databases (NSDE, Orange Book, Purple Book, DailyMed SPL). NDA/ANDA drugs are FDA-approved, BLA biologics are FDA-licensed. Inclusion alone does not guarantee current market availability or imply FDA endorsement.

Medical disclaimer: This AI-generated content is provided for educational purposes only and does not constitute medical advice. Always consult a licensed healthcare professional for diagnosis or treatment decisions.